Constance Weisner Felicia Chi Sujaya Parthasarathy Jennifer Mertens Division of Research, Kaiser Permanente University of California, San Francisco CALDAR Summer Institute UCLA Integrated Substance Abuse Programs (ISAP) Overview Integrating Substance Use services with health care • A conceptual model of integration using primary care • Development of approach • Screening, Brief Intervention, and Referral to SU Treatment • Integrating care during SU treatment • Continuing Care following SU treatment • Research Opportunities Primary care as the anchor for ongoing medical care, monitoring of SU and mental health problems Disease Management/Chronic Care Approach Individuals with a serious chronic problem (e.g., diabetes) are treated in specialty care, and when stabilized return to primary care for management and monitoring Similarly, alcohol and drug dependence are chronic conditions requiring ongoing care or management delivered in more than one setting Von Korff M, Gruman J, Schaefer J, Curry SJ, Wagner EH. Collaborative management of chronic illness. Ann Intern Med. 1997;127:1097-102. Institute of Medicine. Improving the quality of health care for mental and substance-use conditions: Quality Chasm series. Washington, DC: National Academies Press; 2005 What might a continuing care model for alcohol and drug problems look like? Screen and treat in PC if moderate problem & continue monitoring Refer to SU treatment if needed Primary Care Specialty SU Care Back to PC for monitoring & possible readmission Von Korff M, Gruman J, Schaefer J, Curry SJ, Wagner EH. Collaborative management of chronic illness. Ann Intern Med. 1997;127:1097-102. Bodenheimer T, Wagner EH, Grumback K. Improving primary care for patients with chronic illness. JAMA 2002; 288:1775-9. Why Primary Care? Community Epidemiology Laboratory General Population Survey Agency Systems Alcohol Treatment (22) Drug Treatment (8) Mental Health (8) Welfare (7) Emergency Room (4) Primary Health Care (5) Criminal Justice (1) Weisner, Schmidt & Tam. Addiction, 1995. Prevalence of New Admissions of Problem Drinkers across General Population & Community Agency Caseloads (%) 100 91 80 60 50 40 20 0 53 33 22 11 15 7 24 11 General Private Public Private Public Welfare Mental Jail Drug Population Primary Primary ER ER (621) Health (1147) Trtmt (3069) Care Care (1102) (801) (406) (304) (358) (394) Alcohol Trtmt (381) Data are weighted to adjust each sample for variation in agencies sampling fraction, rate, and fieldwork duration. Distribution of New Admissions1 of Alcohol Dependent2 Individuals in Community Agency Systems Alcohol and DrugTreatment 11.1% Welfare 6.6% Mental Health 3.0% Primary Care 55.7% Criminal Justice 23.5% 1 Data weighed for design effects, non-response, and to a common fieldwork duration so that each agency system sample is shown to its size. 2 Dependence rates over a base of those meeting DSM-III-R criteria across all agency systems. Distribution of New Admissions1 of Weekly 2 Drug Users in Community Agency Systems Alcohol and Drug Treatment 6% Welfare 11% Mental Health 3% Primary Care 43% Criminal Justice 39% 1 Data weighed for design effects, non-response, and to a common fieldwork duration so that each agency system sample is shown to its size. 2 Weekly drug use rates over a base of weekly drug users across all agency systems. Why primary care? • Screening • Ongoing care Monitoring Referral back to SU treatment when needed • Staff-model integrated health care delivery system (medical, psychiatry, SU services) • Serves 3.4 million members (about 40% of insured population in the region) • 18 hospitals, 27 SU and MH outpatient clinics • Electronic medical record • Similarities wtih FQHC’s Screening and Intervention in Primary Care Hazardous Drinkers and Drug Users in Primary Care • Prevalence of 10% for either alcohol or drug problems • Hazardous drinkers and drug users had higher prevalence than other primary care patients of several common medical conditions, including: • Injury • Hypertension • Asthma, emphysema, COPD • Pneumonia • Depression, Anxiety, and Major Psychoses • Higher health care costs • Important for care of chronic conditions (including diabetes) Mertens JM, Weisner C, Ray GT, Fireman B, Walsh K. Hazardous drinkers and drug users in HMO primary care: prevalence, medical conditions, and costs. Alcohol Clin Exp Res. 2005;29:989-98. Ahmed A, Karter AJ, Warton M, Doan JU, Weisner C. The relationship between alcohol consumption and glycemic control among patients with diabetes differs by age and diabetes type: the Kaiser Permanente Northern California Diabetes Registry. J Gen Intern Med. 2008;23 (3):275-282. Medical Conditions: Example from a FQHC Medical conditions With any SU Without any SU P value Depression 22.8 11.6 <0.0001 Major Psychosis 7.3 4.0 0.0184 Any Mental Health diagnosis 30.1 18.8 <0.0001 Low back pain 28.5 10.0 <0.0001 Other pain/chronic pain 50.4 41.6 0.0096 Infectious/parasitic disorders 14.6 10.3 0.0436 Pulmonary /respiratory- COPD 3.7 1.3 0.0118 Hypertension 37.4 31.0 0.0446 Psychiatric Medical Screening, Intervention, and Referral to Treatment in Primary Care: Evidence Base and Research Need • SBIRT in primary care is effective, cost effective, and recommended by national guidelines but has not been widely adopted • Only a few rigorous implementation studies have been conducted in the U.S. Bertholet N, Daeppen JB, Wietlisbach V, et al. Arch Intern Med. 2005;165:986-995. Whitlock EP, Polen MR, Green CA, et al. Ann Intern Med. 2004;140:557-568. Solberg LI, Maciosek MV, Edwards NM. Am J Prev Med. 2008 Feb;34(2):143-152. Saitz R, Svikis D, D'Onofrio G, et al. Alcohol Clin Exp Res. 2006;30:332-338. At-Risk Drinking In Primary Care Need Specialty Treatment Brief Intervention Alcohol Dependent 7.5% At-Risk Drinkers Low-Risk Drinkers Abstainers Institute of Medicine. 1990, and World Health Organization, 2001 Helping Patients Who Drink Too Much: Kaiser’s SBIRT study NIAAA: PI Jennifer Mertens Implementation study of effective interventions Randomization 56 Facilities 1/3 of PC modules randomized to PCP Arm PCPs receive SBIRT training with CMEs 1/3 of PC modules randomized to ‘NPP’ arm •MAs are trained to Screen •BMS/Nurses/CHEs •Receive training (with CME/CEUs) to conduct BI and RT 1/3 of PC modules randomized to control condition Informational session on how to access and use Alcohol Screener Alcohol Screener in EMR 19 Best Practice Alert 20 Primary Outcomes (using the EMR) • • • • Screening rates Brief intervention rates Referral to treatment rates Cost and utilization Secondary Outcomes (Using the EMR) •Compare Effectiveness by Study Arm. •Effectiveness on patient outcomes of: typical quantity consumed days per week consumed alcohol average weekly consumption •Related health outcomes: blood pressure reductions for patients with hypertension diagnoses and, antidepressant adherence (consistent with HEDIS standards) for patients with depression diagnoses who have antidepressant prescriptions. What might a continuing care model for alcohol and drug problems look like? Screen and treat in PC if moderate problem & continue monitoring Refer to SU treatment if needed Primary Care Specialty SU Care Back to PC for monitoring & possible readmission Von Korff M, Gruman J, Schaefer J, Curry SJ, Wagner EH. Collaborative management of chronic illness. Ann Intern Med. 1997;127:1097-102. Bodenheimer T, Wagner EH, Grumback K. Improving primary care for patients with chronic illness. JAMA 2002; 288:1775-9. Integration with Primary Care: During SU Treatment • In specialty care we have a more select population – with high rates of medical and psychiatric problems Controls Prevalence in Adult SU Treatment Patients Vs. Matched (%) (more than 20 conditions) Acid-Related Disorder Arthritis Asthma COPD Migraine Hypertension Lower Back Pain Injury Controls SU patients 0 5 10 15 20 25 Conditional Logistic Regression Results: p<0.01 for all conditions shown Mertens et al. (2003). Archives of Internal Medicine 163: 2511-2517. 30 Prevalence in Adult SU Treatment Patients Vs. Matched Controls (%): ICD-9 Psychiatric Conditions* SU Patients (N=747) Matched Members (N=3,690) Depressive Disorders 28.5% 2.7% Anxiety Disorders 17.1% 2.2% Psychoses 6.7% 0.4% *all p<.001 Mertens JR, Lu Y, Parthasarathy S, Moore C, Weisner CM. Medical and psychiatric conditions of alcohol and drug treatment patients in an HMO: Comparison to matched controls. Arch Intern Med. Nov 10 2003;163:25112517. Integrating Primary Medical Care During SU Treatment: Evidence Base • Systematic reviews indicate that a small but growing literature suggests effectiveness of integrating primary medical care during SU treatment, but: Few randomized trials Lack cost-effectiveness analysis Butler M, Kane RL, et al. Integration of Mental Health/Substance Abuse and Primary Care. AHRQ Publication No 09-E003. October 2008. Druss BG and von Esenwein SA. General Hospital Psychiatry. 2006; 28(2): 145-53. Willenbring ML and Olson D. Arch Intern Med. 1999; 159 (16): 1946-52. Friedman P, Zhang Z, et al. J Gen Int Med. 2003; 18: 1-8. Outcomes of Integrating During SU Treatment Randomized those entering SU treatment to receiving their primary care in the SU clinic vs. receiving it as usual care in the clinics. Those with medical problems receiving integrated services were almost twice as likely to be abstinent at 6 months, and was cost-effective. There is still an effect at five years. Weisner C, Mertens J, Parthasarathy S, Moore C. Integrating primary medical care with addiction treatment: A randomized controlled trial. JAMA. Oct 2001;286(14):1715-1723. Mertens JR, Flisher AJ, Satre DD, Weisner C. (2008). The role of medical conditions and primary care services in 5-year substance use outcomes among chemical dependency treatment patients. Drug and Alcohol Dependence 98(1-2):45-53. What might a continuing care model for alcohol and drug problems look like? Screen and treat in PC if moderate problem & continue monitoring Refer to SU treatment if needed Primary Care Specialty SU Care Back to PC for monitoring & possible readmission Von Korff M, Gruman J, Schaefer J, Curry SJ, Wagner EH. Collaborative management of chronic illness. Ann Intern Med. 1997;127:1097-102. Bodenheimer T, Wagner EH, Grumback K. Improving primary care for patients with chronic illness. JAMA 2002; 288:1775-9. Case for Primary Care Continuity after SU Treatment • SU treatment population has a high level of chronic or on-going medical and mental health conditions • It’s unrealistic to expect that chronic health problems will disappear with SU treatment • Health problems can cause relapse • A mechanism to continue to monitor SU problems Conceptual Approach: Disease Management/Chronic Care Approach • Individual with a serious chronic problem (e.g., diabetes) is treated in specialty care, and when stabilized returns to PC for management and monitoring referred back to specialty care for services as needed in the course of their health care • Similarly, SU dependences is a chronic condition requiring ongoing care or management delivered in more than one setting • Not replacing aftercare – can be placed on top of all types of aftercare Von Korff M, Gruman J, Schaefer J, Curry SJ, Wagner EH. Collaborative management of chronic illness. Ann Intern Med. 1997;127:1097-102. Institute of Medicine. Improving the quality of health care for mental and substance-use conditions: Quality Chasm series. Washington, DC: National Academies Press; 2005 A Model of Continuing Care Following SU Treatment Observational study as a first step informing an intervention Three components: 1) Regular primary care as anchor 2) Readmission to SU treatment when needed 3) Psychiatric services when needed Patient characteristics and data sources of patients at 1 year, 5 year, 7 year and 9 year follow-ups) • KP Chemical Dependency Recovery Program (CDRP) in Sacramento, California • Study participants: 1,951 adult individuals (i.e. 18 years or older) entering treatment at the CDRP during April 1994 – April 1996 and April 1997 – December 1998 (93% of intakes) • Follow-up interviews at 1 year, 5 years, 7 years and 9 years, with response rates of 90%, 86%, 84%, and 78% A Model of Continuing Care Following SU Treatment • Need for specialty care: √ having a non-zero Addiction Severity Index (ASI) score for the corresponding SU or MH problem domain at the prior interview time point • Membership and service utilization from the health plan’s administrative databases Nine-Year Primary Care-Based Continuing Care Outcomes (Observational Study) • Patients receiving continuing care were more than twice as likely to be remitted at each follow-up over 9 years (p<.0001).* √ Results were consistent by gender, medical and psychiatric severity, and for all age groups except those older than 50 years. * mixed-effects logistic regression model controlling for time/follow-up wave, demographic characteristics, severity, and completion of index SU treatment Chi FW, Parthasarathy S, Mertens JR, Weisner C. (2011). Continuing care and long-term substance use outcomes in managed care: initial evidence for a primary care based model. Psychiatr Serv 62(10):1194–200.. Receiving Continuing Care1 vs. Remission Over 9 Years, Stratified Analyses2 Adjusted OR 95% CI P value 2.38 (1.59, 3.57) <0.0001 20-29 years 5.11 (1.63, 15.97) 0.0055 30-39 years 2.52 (1.24, 5.13) 0.0124 40-49 years 2.14 (1.10, 4.20) 0.0182 ≥ 50 years 0.90 (0.30, 2.71) N.S. Female 1.80 (1.03, 3.16) 0.0202 Male 3.11 (1.70, 5.70) 0.0003 High 2.45 (1.39, 4.31) 0.0025 Low 2.28 (1.25, 4.16) 0.0031 High 2.80 (1.56, 5.03) 0.0004 Low 1.87 (1.04, 3.36) 0.0272 All Age group Gender Baseline medical severity Baseline psychiatric severity Note: 1 Receiving continuing care was defined as having regular PC and receiving both CD and psychiatric services when needed. 2 All models adjusted for the same set of covariates as in the model presented in the previous slide. Nine-Year Primary Care-Based Continuing Care Costs (Observational Study) • Those receiving continuing care in the prior interval were less likely to have ER visits and hospitalizations subsequently (p<.05).* *Linear mixed model controlling for age, gender, employment and marital status, whether completed treatment Parthasarathy S, Chi FW, Mertens JR, Weisner C. (2012). The role of continuing care on 9-year cost trajectories of patients with intakes into an outpatient alcohol and drug treatment program. Med Care 50(6): 540-6. Average Cost per Member Month Average Costs by Number of Continuing Care Components $350 Other Costs $300 $250 CD Treatment COst $200 $150 Psychiatric Services Cost $100 Primary Care Cost $50 ER Cost $0 0 1 2 3 Number of Continuing Care Components Fulfilled Inpatient Cost Summary of Continuing Care Outcomes and Cost • Continuing care that includes regular primary care and specialty care predicted remission • Those receiving all components of continuing care had lowest overall health care costs Costs reductions especially from hospitalizations Promoting a continuing care model that integrates different elements of the health care system appears to be costeffective People used far less of the services to which they had access Realities • Difficult to get people to use health care appropriately – even when they have access • From SBIRT studies, training physicians doesn’t always work. • Health system realities: Patients may not see same physician over again. Interventions Linking Primary Care and SU Treatment Post-Treatment • Uninsured individuals in detox from alcohol, heroin, and cocaine • Medical and social work team in detox • Primary care appointment made and letter sent to primary care provider Continuing Care Linkage Study • Clinical Intervention to link SU patients with primary care for ongoing monitoring • Merges what we know from chronic care of other diseases with what we know about recovery patient activation sessions linkage phone call with primary care physician Continuing Care Linkage Study • Chronic Care/Disease Management Model merged with Recovery Model Patient Activation/Empowerment o Wellness focus o Address stigma – relationship with physicians o Dealing with health care system Patient Activation • Building the belief that the patient plays an important role in his or her health • Supporting patients to develop the confidence and knowledge necessary to take action • Increasing patient motivation to actually take action to maintain and improve health, and • Developing strategies to “stay the course” even under stress Patient-centered Activation Curriculum First Part: group sessions • SESSION 1: Me and my health • SESSION 2: Lifestyle and Prevention • SESSION 3: Navigating the system • SESSION 4: Prepare, communicate and participate • SESSION 5: Collaborate and integrate • SESSION 6: Reduce your risk and maximize your health Some examples: Using Health IT Aids • Graphing blood pressure • Planning prevention tests • Preparing for doctor visit • Emailing doctor • Sleep/weight-loss programs • Changing doctors Learned from using the EMR We reviewed his lab results which pt found exciting “wow this is so cool, I like that it tells me the normal range to be in, I should look at this more often.” "I have gained weight since being in recovery with all my meds. So I signed up for Balance and a nutrition class so I can improve my diet. I also listen to those podcasts they really help with my insomnia. One participant shared that, since last week, she has been listening to 3 podcasts/day, and that she has found this to be very helpful in her recovery. She stated, "I never knew how many negative messages were in my head, and they provide such a positive perspective for my health". The participant who feared working on the computers due to her dyslexia, tearfully noted that not only did she overcome challenges that seemed almost impossible to solve (ordering a new password after being locked out of the system), but she practices on her own at home which makes her feel empowered and proud. Using the EMR, continued One participant noted that after class last week, he went home, emailed his new doctor and discussed the skin condition he has been worried about for years. He said "thank you for kicking my butt to do that, I never would have emailed her until you showed me how." Thank you for going through my medical record with me, there were things I would not have looked for and it was good to review my past test results. One participant reported that checking his glucose level improved his mood because it was in normal range and he is at genetic risk of diabetes One person reported being prescribed medication, but not having sufficient information regarding pharmacy locations or the medication itself. After, attending Navigating the System, he now knows how to locate the pharmacy and plans to take his medication. Linking with Primary Care Second part: Linkage Phone Call Therapist, patient, and primary care physician (No training of physicians) Vignettes One participant related to the group that he never would have found the courage to tell his PCP about his addiction and/or recovery. He related how he felt that this call changed his life and recovery program, as it not only allowed him to include his PCP in his recovery support system, but it also prevented him from attempting to seek opiates from this provider in the future (as he had done in the past). He also shared how empowering it was for him to talk to his doctor about what is working and his successes. Vignettes During the call, the PCP asked if he was testing his blood sugar daily. He reported some shame about not doing that as he has gained weight in early recovery - at which point he noted his desire to try nutrition and exercise classes. The PCP positively reinforced his behavior and said "why don’t you come in for some fasting blood tests this weekend and we can take a look to make sure you are doing ok.” Coordination and Linkages: A Continuum Continuum of Coordination On-site program/out-stationing between SU agencies and health clinics Friedmann PD, D'Aunno TA, Jin L, Alexander JA. Medical and psychosocial services in drug abuse treatment: do stronger linkages promote client utilization? Health Serv Res. 2000;335(2):443-65. Institute of Medicine, Improving the Qulity of Health Care for Mental and Substance-Use Conditions, 2006 Gaps in Research on Linkages • Need to develop more/different components or approaches • Need to study other health systems • Need to adapt for adolescent treatment Recovery-Oriented System of Care ROSC: coordinated networks of organizations, agencies, and community members that coordinate a wide spectrum of services to prevent, intervene in, and treat substance use problems and disorders. Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment. Recovery-Oriented Systems of Care. SAMHSA's Partners for Recovery. (2011). http://pfr.samhsa.gov/rosc.html. Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment. RecoveryOriented Systems of Care. SAMHSA's Partners for Recovery. (2011). http://pfr.samhsa.gov/rosc.html. Why is now a good time? Critical mass of circumstances affecting all health systems: Opportunity to move the addiction field into health care • Health reform • Addiction treatment parity • Electronic medical records • Performance measures: HEDIS measure – CPT codes • Medicaid Waivers in public health centers • NIH/SAMHSA/ONDCP focus on training and treatment • Concern in health systems about chronic pain and opioid prescribing Drug and Alcohol Research Team, Division of Research Interview Supervisor Investigators Cynthia Campbell, PhD Jennifer Mertens, PhD Derek Satre, PhD Connie Weisner, DrPH, LCSW Group Leader Stacy Sterling, MPH, MSW Health Economist Sujaya Parthasarathy, PhD Analysts Felicia Chi, MPH Jessica Chung Allison, PhD Andrea Kline Simon, MS Wendy Lu, MPH Tom Ray, MBA Project Coordinators Agatha Hinman, BA Tina Valkanoff, MPH, MSW Gina Smith Anderson Research Associates Georgina Berrios Diane Lott-Garcia Melanie Jackson Cynthia Perry-Baker Barbara Pichotto Martha Preble Lynda Tish Sabrina Wood Research Clinicians Thekla Brumder, PsyD Ashley Jones, PsyD Amy Leibowitz, PsyD Clinical Partners David Pating, MD Charlie Moore, MD Matthew Tarran, PhD Joe Gonzales, LCSW KPNC Chemical Dependency Quality Improvement Committee KPNC Adolescent Medicine Specialists Committee KPNC Adolescent Chemical Dependency Coordinating Committee Joe Guydish and Treatment Research Center at UCSF Constance.Weisner@kp.org conniew@lppi.ucsf.edu New Admissions of Weekly Drug Users and Alcohol Dependent Individuals in Community Agency Systems, Female vs. Male Weekly Drug Use 1 Alcohol Dependence Female Male Female Male SU Treatment (%) 3.8 6.6 7.2 13.2 Mental Health (%) 3.8 2.1 4.5 2.3 Welfare (%) 20.0 8.8 6.3 6.8 Criminal Justice (%) 15.7 54.0 8.9 30.8 Primary Care (%) 64.0 28.5 73.2 47.1 Data weighted for design effects, non-response, and to a common fieldwork duration so that each agency system sample is shown to its size. 2 Weekly drug use rates over a base of women weekly drug users across all agency systems; dependence rates over a base of those meeting DSM-III-R criteria across all agency systems. Medical Conditions of Adolescents in CD Treatment vs. Matched Controls Adolescents in alcohol and drug treatment had significantly higher prevalence of several medical conditions, including: Asthma Injury Sleep disorders Pain conditions (abdominal pain, muscle pain, and headaches) STDs Benign conditions of the uterus Dermatology conditions Gastroenteritis Mertens J, Flisher A, Sterling S, Weisner C. Medical conditions in adolescent alcohol and drug treatment patients in a private health plan: comparison with matched controls. Scientific Meeting of the Research Society on Alcoholism, Santa Barbara, CA, June 29, 2005. Psychiatric Conditions of Adolescents in CD Treatment & Matched Controls (%) Tx Intakes Controls p-value Depression 36.3 4.2 <.0001 Anxiety Disorder 16.3 2.3 <.0001 Eating Disorders 1.2 0.43 .067 ADHD 17.2 3.0 <.0001 Conduct Disorder 19.3 1.2 <.0001 Conduct Disorder (w/ODD) 27.3 2.3 <.0001 Any Psychiatric DX 55.5 9.0 <.0001 HIV Risk Behaviors among Adolescents in CD Treatment Boys (N=276) % 2 Girls (N=143) % 4 Sharing needles or works 1 1 Never/inconsistent condom use (of those reporting ever having sex) 35 53* Sex with multiple partners, past 6 months + never/inconsistent condom use 39 43 3 37 52 14* Risky Behaviors Injection drug use (IDU) Male homosexual activity/female bisexual activity Ammon L, Sterling S, Mertens J, Weisner C. Adolescents in private chemical dependency programs: who are most at risk for HIV? J Subst Abuse Treat. Jul 2005;29(1):39-45. Examples of Recovery-Oriented Activities Prevention • • Early screening before onset Collaborate with other systems, e.g., Child welfare • Stigma reduction activities • Refer to intervention treatment services Intervention • Screening • Early intervention • Pre-treatment • Recovery support services • Outreach services Treatment • • Treatment services Recovery Support services • Alternative services and therapies • Prevention for families and siblings of individuals in treatment Post-treatment • Continuing care • Recovery support services • Check-ups • Self-monitoring Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment. Recovery-Oriented Systems of Care. SAMHSA's Partners for Recovery. (2011). http://pfr.samhsa.gov/rosc.html. A Recovery-Oriented Systems Approach A recovery-oriented systems approach supports person-centered and self-directed approaches to care that build on the strengths and resilience of individuals, families, and communities to take responsibility for their sustain health, wellness, and recovery from alcohol and drug problems. Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment. Recovery-Oriented Systems of Care. SAMHSA's Partners for Recovery. (2011). http://pfr.samhsa.gov/rosc.html.