Atrial Myxoma

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A lady with acute SOB

Sammi Pe

Case Presentation

• 54/F

• Cat II

• BP 129/69mmHg P 128

• Temp 36.9

• SpO2 78% ( 100% O2)

• Triage : SOB since afternoon, cough with sputum, mild chest discomfort

What will you do ?

What further history need?

What further Hx

• Good Past Health

• Domestic helper

• SOB since ~2 hrs ago

• Mild cough with yellowish sputum xdays become blood stained on AED

• No fever

• Chest discomfort today ( tightness)

• Palpitation +ve

More hx from employer

• Mild exertional SOB x several days

• Need resting after her work

• No fever all along

• No Travel hx

• Work in HK x ~17yrs

• No GI upset/ abd pain

• Not on regular medication

• Non-smoker, non-drinker

P/E

• Alert GCS 15/15

• BP 139/78 P 120

• RR 48

• Sit up for breathing

• SpO2 80% on 100% O2

• Recheck Temp 37.2

• H ’ stix 13.2

P/E

• Chest: AE fair with bilateral basal crep, occ wheeze

• Abd soft

• HS dual, no murmur

• No ankle edema

What will you do next ?

• ABC

• 100% O2 mask

• HB set

• Blood x CBC, L/RFT, Trop I , Clotting

• ECG

• i stat ( arterial)

• CXR

ECG x 2

i stat (arterial, on 100%O2)

• pH 7.398

• pCO2 5.39 kPa

• pO2 5.8 kPa

• BE 0

• HCO3 24.9 mmol/L

• SO2 79%

• Na 141 K 3.5 i Ca 1.21 Hb 14.6

Our Patient

Problem:

Sudden onset SOB

Desaturation even on 100% O2

Type I Resp Failure

What is yr DDx?

Type I Resp Failure

Typically due to V/Q mismatch

PaO2 low (< 60 mmHg(8.0 kPa))

PaCO2 normal or low

PA-aO2 increased

• Parenchymal disease ( V/Q mismatch)

• Diseases of vasculature and shunts: right-to-left shunt , pulmonary embolism

• interstitial lung diseases: ARDS , pneumonia , emphysema .

Patient was still in distress even on 100% O2

What will you do then?

• Patient was put on CPAP

• Lasix 40mg iv

• BP 110/70

• Clinically improved

• CXR film A/V … .

What is yr

Diagnosis?

CXR

APO

.

? Other drug(s) to be considered

? Underlying cause

CCU was consulted

Medications…

• Nitrates

– Vasodilation

– Reduced preload and afterload

– Improved CO

– Rapid effect

– Not prescribed likely due to BP on low side

• Diuretics

– Reduced plasma volume / preload

– Pulmonary vasodilatation

• ACEI

– Reduced afterload

– Improved CO

Underlying Causes

• ACS

• HT

• Aortic/mitral valve disease

• Arrhythmias

• VSD

• Cardiomyopathy

• Acute myocarditis

• Pericardial disease

• Atrial myxoma

• Echo was performed…

What is show in the

Echocardiogram?

Our case

CCU input

• ECHO:

• LA mass ~4cm

• Likely atrial myxoma

• Trivial MR/AR

• Normal LV size and

EF

Our Patient

APO secondary to large atrial myxoma

• Transfer to CCU then CTSU for further

Mx.

Progress

• Emergency excision of atrial myxoma

– 6x5cm encapsulated LA tumour attached to inter-atrial septum.

– Causing obstruction & pul edema

– Bi-atrial exploration + excision of tumour

• Extubated on D1

• Post-op echo: EF 70%

• no PE

Day 0 Day 1

Day 2

Day 3 Day 4

Day 20

Patient was discharge on D8 and SOPD FU

On Day 20

Good Recovery, Class I II , ET 3-4 FOS

Atrial Myxoma

Background

Most common 1 ° Heart tumour (40-50%)

90% solitarty and pedunculated

– Multiple tumours occur in 50% of familial case

10% familial ( autosomal dominant)

75-85% occur in LA ~25% RA

Attach to fossa ovalis

Symptomatic ~ 70g 140g

• Myxoma-

– polypoid, round, oval in shape

– Smooth / lobulated surface

– White/ yellow/ brown

– Produce numberus growth factors and cytokines e.g. interleukin-6

Histology

• lipidic cells embedded in a vascular myxoid stroma

• In a series of 37 cases,

• 74% of tumors showed immunohistochemical expression of interleukin-6 while

• 17% had abnormal DNA content

Epidemiology

• US ~ 75 case / million autopsies

• 75% sporadic – Female

• Mean age – 56

• 15% present as sudden death

– tumour embolism, HF, mechanical obstruction

History

Asymptomatic (20%) symptomatic sudden death (15%)

Mechanical interference with cardiac fx embolization

LHF RHF systematic (L) Pulmonary (R)

Exertional SOB fatigue infarct / haemorrhage PE

Orthopnea peripheral edema of viscera Pul infarction

PND ascites e.g. CVA

Pul edema visual loss

Pul HT

Postural dizziness

Constitutional symptoms : fever, Wt loss, arthralgias, Raynaud ~ 50% of patient due to interleukin-6 overporduction

Physical

• ↑ JVP

• Loud S1

( delay mitral valve closure)

• Early diastolic sound (Tumor plop) tumor hit against the endocardial wall

• Diastolic atrial rumble

( obstruction in MV)

• MR/ TR

( valvar damage/ prolapse)

DDX

• Mitral Regurgitation

• Mitral Stenosis

• Pul Embolism

• Pul HT , primary

• Tricuspid Regurgitation

• Tricuspid Stenosis

Ix

• Lab: ESR, CRP, CBC, serum interleukin-6

• CXR

• ECHO

• need to differentiate thrombus from myxoma

– Thrombus ( in posterior portion, in layers)

– Myxoma ( presence of stalk and mobility)

• MRI

(point of attachment )

• CT scan

Treatment

• Medical treatment for CHF and arrhythmia

• Surgical excision is the definitive tx

• Safe and curative

• Recurrence is possible if incomplete excision

Thank you

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