Cognitive Decline and the Default American Lifestyle Courtney Roberts http://www.ncbi.nlm.nih.gov/pmc/articles/PM C3132766/ Introduction • Stagnant and poorer cognitive function in the elderly • Technology can decrease cognitive and physical activity • Fitness is needed for good brain performance • Sedentary forms of work, transportation, and leisure undermine fitness The Brain • Cognitive function= brain function • Works even when person rests • Works harder when person thinks, speaks, reads, acts, etc. • Body needs to be able to deliver oxygen & glucose to the cerebrovascular system and needs to route blood to the active neurons in order to properly function • Depends on cardiovascular, respiratory, metabolic fitness Default American Lifestyle • Physical activity in work, transportation, & recreation decreasing • Gas engines, electric motors, and electronic communication make travel, work, play, and commerce sedentary • Shift from home-made to manufactured and restaurant meals • Food being made for production, transportation, marketing, and convenience, NOT nutrition • As people age, they experience severe problems controlling blood pressure, cholesterol, and blood sugar or delivering oxygen on demand • Bottom line= American lifestyle is unhealthy Default Lifestyle and the Elderly • Muscles become atrophied and joints get inflamed and calcified • Bones become brittle and misaligned • Hearts grow weak and arteries get clogged and hardened • They begin to use medication for… • Blood pressure, cholesterol, glucose, bowel movements, urination, stomach acidity, reflux, and to stifle anxiety, depression, and pain Threats to Cognitive Function • BMI: provides the most visible and readily measured sign of hidden physiological trends • Low or declining BMI in elderly people usually indicates an unhealthy loss of muscle and bone as well as fat • Cognitive dysfunction can stem from BMI’s relationship with other factors • High blood pressure, high ratios of low-density to high-density lipoprotein, type 2 diabetes, insulin resistance, poor blood sugar control, oxidative stress, heart disease, stroke, and deep vein thrombosis • Low physical activity and a higher BMI has a direct association with dysfunction because of low aerobic capacity Bio-Accumulation • Accumulators: • Gather many small effects into one large one and once present they tend to stay present • Exercise, eating habits, body mass, blood pressure, blood triglyceride, cholesterol levels, and insulin resistance • Influence body’s ability to meet brain’s metabolic needs • Represent the sum of many small consequences over time and provide little or no feedback for protective behavioral conditioning Pharm-Accumulation • The overlaying of medications, protraction of their use, and accrual of their side effects and interactions • Creates problems for seniors because they have had the longest time to accumulate problems and longest time to take the drugs • More exposed to complications and interactions and more vulnerable to medications • Seriously threatens cognitive function of seniors • Some drugs may produce dementia and delirium • Some drugs have effects that can impair memory, learning, concentration & lucidity The Baby Boomers • Size of baby boom generation will reshape culture and standards of daily life • As physical demands of life decline, so will levels of physical abilities • Culture, buildings, products, and services will have to adapt to lower average physical abilities • Social norms and built environment adapt to low physical abilities and being to discourage activities that create abilities • Maintaining physical function requires determination to overcome the default lifestyle • Aging population may accelerate trend to lower physical abilities and will therefor lower cognitive function • This will lead to reduction of physical demands on everyone in society Future Implications • Future for cognitive functions remains uncertain, but signs are not good • The aging of the baby boomers combined with the body mass trends implies that the number of diabetics will increase by 86% in the next 25 years • Social movements need to work to make stairs more accessible and appealing and communities more walkable and they need to promote small changes in lifestyle • People are being encouraged to promote healthier diets and activities • The majority of adult Americans will either be old or obese • In order to override the default, people will need determination and creativity to find a healthier way of living