SMART Platform and API
for Clinical Genomic Apps
Gil Alterovitz
Director, Biomedical Cybernetics Laboratory
Assistant Professor, Harvard Medical School
100 Most Influential People of the Millennium
1 Johann Gutenberg (mass media- movable type)
2 Isaac Newton (gravity)
3 Martin Luther (Protestant Reformation)
4 Charles Darwin (evolutionist writer)
5 William Shakespeare (Renaissance playwright)
6 Christopher Columbus (explorer)
7 Karl Marx (19th c. political writer)
8 Albert Einstein (physicist)
9 Nicolaus Copernicus (astronomy)
10 Galileo Galilei (astronomy)
Movable type
• Allows for large populations to be able to
absorb knowledge via books, newspapers,
etc.
Vendor-specific apps: calendar,
calculator, etc.
Independent apps
Apps did not work with other
systems and did not evolve
much over time.
Developer and user community
is engaged
No long-tail/custom
applications- e.g. family
history app
Long-tail apps available
Plug does not fit
Issues in Communicating Genetic
Information
• No simple standard API (Application
Programming Interface)
• Contents are essentially the same
o
Sequences (ATGC..) and genetic files
• But, data are structured differently
• Different approaches of authentication
SMART Provides a Solution
• Substitutability Medical Applications Reuseable
Technology
• Simple design of API
o
Geared toward developers and users
• Integration with clinical data
What is SMART?
• Substitutable Medical Apps Reusable
Technology
• Accelerate medical application
innovation and research
• Develop medical app community
• Remove developer roadblocks
Substitutability = Re-Use
Got
Statins?
BP
Centiles
Cardiac
Risk
SMART-Enabled
SMART-Enabled
PCHR
EMR
SMART-Enabled
HIE
SMART - AMIA 2012 - 04Nov2012
Substitutable Apps Needs
API
Resource oriented, everything a URL
Data Model
Context (container, user, patient)
Medical (problems, allergies, …)
Authentication
Consistent delegation, web standards (OAuth)
UI
Standards-based integration (HTML5)
SMART - AMIA 2012 - 04Nov2012
App
Platfor
m
SMART-Enabling i2b2
Add:
SMART cell
Mapper cell
Patient-Centric
View app
i2b2 Hive
Patient-Centric View App
SMART
Cell
CRC
Mapper
Cell
Ontology
SMART - AMIA 2012 - 04Nov2012
Any
SMART
App
Boston Children’s Hospital
Cerner EMR
16 Months
SMART - AMIA 2012 - 04Nov2012
SMART Genomics API
• Enables integration of genomic data from
heterogeneous sources
• Enables integration of clinical and genomic data
• Re-usability eliminates developer barriers
• Promotes the use of genetic data for research
SMART Genomics Platform
PopUp→
Top-Level Genomics Advisor Displays
SMART Genomics Advisor App Integration
24Oct2012
Genomics Advisor: Detailed Pop-Up
SMART Genomics Advisor App Integration
24Oct2012
SMART - AMIA 2012 - 04Nov2012
Example App: Dbear SMART EMR
Problem: High cost of chronic disease management
and issues with long-term patient compliance in
diabetes, especially in pediatric cases.
Solution: Increase compliance by integrating toy
bear from Sproutel with SMART EMR for physicians
and to provide parent/child feedback.
Details: Integrated bear with the Telecare glucose
meter / pump technology to provide clinical data to
SMART EMR
* Provides kids with a “fun” way to measure glucose
and take insulin. Provide live data for
clinicians/patients to view.
* Interactive bear avatar gives feedback to patients.
* Engages patients to increases their likelihood to
comply with their diabetes treatment.
iPad Apps
DB EMR
First program to integrate genomic,
device, EMR/Personal Health Record
information.
First program to integrate patient, patient
devices (e.g. bear/glucose meter), care
giver, and physician data into a unified
view to facilitate collaboration on patient
care.
First mobile app to integrate
genomics/sequence information and
clinical information.
Genomics Advisor
• Another app using
•
the SMART API
Gives analysis
based on genetics