PRESENTED BY: Dr. Areej Al-jabaly A: Drugs Effects B: ELECTROLYTE C : DISEASES D: NORMAL VARIANTS Digoxin : Therapeutic Effect * ST segment depression ( reversed tick ) * Shortening of the QT interval T wave inversion Toxic Effect : Any type of arrhythmia especiall ventricular octopi Quinidine: and related drugs like ( procinamide , Disopyramide , phenothiazine, Tricyclic, Antidepressant, Amiodarone ) * P wave widening * QRS widening * Prolonged QT interval ( longer than half of the RR interval) • * Increase U wav amplitude * ST segment depression * Increase U wav amplitude Hyperkalemia : 1- Mild to moderate hyperkalemia (5 -7 mEq/L ) * Tall symmetrical peaked ( ( tents T waves with narrow bas . 2- More severe hyperkalemia (8 - 11 mEq/L ) * widening of QRS * PR interval prolonged 3- Severe case > 11 * ECG resemble a sine wave * P wave disappearance (atrial arrest) Hypokalemia : Mild( 3-3.5) to moderate ( 2.5 – 3) mEq /L * Progressive ST segment depression * Progressive decrease in T wave amplitude * increase U wave amplitude Severe (< 2.5 mEq /L( * Fusion of T and U wave * Increase QRS duration and amplitude * Increase P wave duration and amplitude * QT interval usually slightly prolonged Hypercalcaemia: Marked shortening of the QT interval due to shortening of the ST segment Hypocalcaemia: Prolong the ST segment without affecting the T wave Renal failure : Triad of * LVH (HTN) * Peaked T wave (Hyperkalemia) * Prolong of the QT interval (Hypocalcemia) Pericardial Effusion: Triad of * Low voltage QRS complexes (0.5mv or less) * low to inverted T waves in most leads * Total electrical alternans Thyroid disease : A: Hypothyroidism: * Low voltage ECG * Sinus bradycardia * Inverted T waves without ST segment deviation in many or all leads ( slow and low ECG ) B:Thyrotoxicosis: * Unexplained AF ( sinus tachycardia at rest) * High voltage ECG * Decrease of QT interval * Prominent U wave in association with tachycardia Acute Pericarditis : * Diffuse ,Upward concave ST elevation * PR depression (specific but less sensitive ) * Almost associated with sinus tachycardia Acute Myocarditis : * Non specific T wave change. * Depression or elevation of ST segments . * Prolonged QT interval . CVA: * Abnormal & widened T waves that may be deeply inverted or tall & peaked . * Prominent U waves. * Prolonged QT interval . These changes are termed CVA pattern & usually resolved with time . COPD : * RAD * Absent R wave in precordial leads. * Prominent R wave in Rt precordial leads & ST segment depression when there is RVH * Prominent P wave in leads (P inferior pulmonale ) resulting from Rt atrial abnormality . * Occasionally SI , SII , SIII syndrome . * Rarely in 10 % of patients LAD Pulmonary embolism : * Sinus tachycardia. * Rt ventricular strain , appearance of ST-T changes in VI ,VII. * SI QIII TIII more specific but less sensitive ( due to acute Rt ventricular dilatation ) * ST depression . * Acute RBBB ( rSR' in result from Rt VI) ventricular dilatation Amyloidosis : * Low voltage of all wave in limb leads * Marked LAD * QS or minimal R wave in V1V3 or V4 Early repolarization syndrom: * ST elevation : 1- may raised to 2 mm above the baseline . 2- It always follow the S wave . * Tall R & ST-T change in the Lt precordial leads . * Relatively tall & frequently symmetrical T wave , rarely T wave inversion. * No reciprocal changes except ST segment depression in aVR . Hypothermia : * J wave or ( Osborn wave ) it is localized to the junction of the end of QRS complex and beginning of the end of ST segment * Prolongation of QRS complexes * Depression of ST segment * T wave depression * Prolongation of QT interval * Sinus bradycardia * First and second - degree heart block * Ectopic rhythm Obesity : * Displacement of heart by elevated diaphragm to the left but within normal range QRS axis * Increasing the distance between the heart and the recording electrodes although the true low voltage QRS amplitude is rarely appears Pacemaker: THANK YOU