Team Members:
Jon Klein
Nguyen Vu
Kyle Menges
Christine Lowry
Chris Stein
Priya Narasimhan
Julie Coggshall
Pg.1
Meeting Timeline
Start Time
Topic of Review
10:00
Introductions, Review Agenda
10:02
Design Review 1 Action Items
10:03
System Design and BOM
10:15
Fluids Analysis – Electrical Simulation, Results
10:35
Blood Tank – Bubble Rise Time, Fluid Extraction
10:40
Water Bath – Heat Transfer
10:45
Tubing – Heat Transfer
Automated Resistance - Linear motor’s force
10:50
approximation
Compliance Tank – Arterial Tank Dimensioning,
11:00
Electrical Equivalent Model
11:15
Custom LVAD Connection
11:20
System Drain – Saline Flush
11:25
Pressure, Flow, and Temperature Sensors and DAQ
11:50
LabView Front Panel Concept
11:55
Wrap-up
Pg.1
To review the detailed design
proposal to ensure design adequacy.
Pg.2
1. Generate pressure and
flow curves for static system
(automatically adjusted)
2. Extracting fluids while running to determine
damage to blood
3. Process data to generate pressure and flow
curve for dynamic system (scaled model of the
physiological circulatory system working with a
PVS)
Pg.5
Item #
Description
Responsible
Comments
Valve and non-valve
connections
Calculated bubble rise
time
A001
Create Quick Connect Design
IE-Jon
A002
Reservoir Calculations – Air Bubbles
ME-Nguyen
A003
Temperature Control – Heating Tank, find out what
changes are in the human body with regards to
temperature?
ME-Chris
Heating element,
water bath
A004
Should we use the flow sensors Dr. Day has?
EE-Priya
Yes
EE-Priya
Use Bleed port
ME - Kyle
Automate clamp
EE-Priya
Do not need
Ideal value ~2 mL/mm
Hg, range varies for
different diseases
Disposable syringe,
A005
A006
A007
A008
A009
Pressure Sensor Selection – are resolution, output
format and frequency response appropriate? Will
sensor trap blood?
Select Resistance Generation Method – research
automated clamp valve
Compliance Tank Analysis – Do we need two tanks?
Compliance Tanks – What are the clinical comparisons
for the compliance values, what about different disease
states.
Blood removal - Look into self healing membrane.
ME-Christine,
Nguyen
ME - Chris
Pg.4
Engr Spec
#
Metric
ES1
ES2
ES3
System Leakage
Systemic Vascular Resistance
Arterial Compliance
ES5
ES6
ES7
ES8
ES9
Blood damage
Portability
Drain Time
Fill Time
Cost
ES10
Blood System Volume
ES11
ES12
ES13
ES14
ES15
ES16
ES17
ES18
ES19
ES20
ES21
ES22
ES23
ES24
Units
Importance
System Properties
# leak locations
5
MPa·s/m3
5
mL/mm Hg
5
g Hgb/100 ml
minutes
minutes
minutes
U.S. Dollars
3
3
3
3
3
liters
3
Fluid Properties
Viscosity
N·s/m2
5
3
Density
kg/m
5
Data Management
Pressure
mm Hg
5
Pressure Accuracy
mm Hg
5
Flow Rate
liters/minute
5
Flow Rate Accuracy
liters/minute
5
Temperature
degrees C (F)
5
Temperature Accuracy
degrees F
5
Data Processing/Output
seconds
3
Sample Extraction
Sample Extraction Time
seconds
3
Sample Extraction Size
milliliters
3
Test Rig Physical Dimensions
Height
inches
1
Length
inches
1
Width
inches
1
Ideal Value
Lower
Limit
Upper
Limit
0
100
2
0
90
1
2
120
2.2
16
45
15
20
2000
12
1
5
5
1000
20
60
30
30
3000
1
0.5
3
For blood testing - Approximately $100/liter of
blood
0.0027
1060
0.0005
800
0.0035
1500
Water at 37 C (.000653), Blood at 37 C (0.0027)
Water at 37 C (992), Blood at 37 C (1060)
100
0.2
6
0.05
37 (98.6)
0.1
10
0
0.001
0
0.001
21 (70)
0.01
0
200
Current loop pressure sensors measure ±15 psi
0.5
10
Adult flow rate approximately 6 lpm
0.1
49 (120)
0.5
60
Time to process data into graphical representation
30
4
15
2
60
5
48
36
30
36
12
12
60
48
36
Notes
Reflects the average range for human body
at approximately 100 mm Hg fluid pressure
Must be biocompatible to use and not damage
blood
How long it takes to prepare and actually move
Somewhere between 2-5 ml
"Cart size"
Summary
Number of 3's
Risk Area
Cost
Risk Item
Likelihood Severity
(1-3)
(1-3)
2
RPN
Total
3
Severity Risk Priority
Level
Number
Description/Comment
Likelihood
Pressure Sensors
Desired sensor accuracy not within
budget
1
2
3
Find suitable DAQ to achieve
accuracy
DAQ
Dedicated DAQ system not within
budget
3
2
6
Investigate costs, potential for
sharing existing DAQ system
Compliance Tank
Desired compliance value not
achieved
2
3
6
Early milestone in test plan to ensure
enough time to fix the problem
2
Monitor fluid and VAD temperature,
implement temperature control
system
4
Research and verify the proper
mixture of water/glycerin is used,
control/maintain temperature
Physiological Temperature
Simulation
Viscosity
System temperature is not
maintained
Viscosity variation does not
simulate human blood properties
1
2
2
2
Mitigation Activity
Risk Area
Risk Item
Description/Comment
Inaccurate
Pressure and flow measurements are
measurements inaccurate
Likelihood
2
Severity Risk Priority
Level
Number
2
Mitigation Activity
4
Use proper instrumentation and verify proper
placement. Discuss with experts prior to
purchasing.
6
Debug software, document procedure for DAQ
operation and troubleshooting. Discuss with
experts prior to purchasing.
4
Early milestone in test plan to ensure enough
time to fix the problem
2
Early milestone in test plan to ensure enough
time to fix the problem. Use alternative fill
method to reduce bubble formation
Measurement
Design
DAQ Error
Instrumentation and DAQ not
communicating properly, DAQ does not
collect or output data properly
Leak
System or components leak causing
error in measurement and/or
contamination
Air bubbles
Air bubbles cannot be removed from
system – tank sizes do not allow for
bubbles to escape, or there are low
points in the system
Valves, sensors, connectors damage
Blood Damage blood
Resistance
Flow restriction does not function
properly
2
2
1
3
2
2
3
3
9
Early milestone in test plan to ensure enough
time to fix the problem. Put in separate,
simplified loop
1
2
2
Design for the implementation of a back-up,
manually controlled resistance method
Severity (choose most severe)
Risk Ranking
Likelihood
3
Highly Likely
> 50%
2
1
Product
Complete product failure, does not function
Meets some customer needs and
Somewhat Likely
specifications, product performs with less
20% - 50%
functionality than desired
Rare
0 - 20%
Performance of product is not impacted
Project
Injury
Complete project failure
Severe injury,
potential death
Moderate impact to budget schedule
Treatment
required
No impact to project budget or schedule
Minor or no injury
Likelihood
Severity
RPN
Red
3
3
6
Yellow
2
2
3
Green
1
1
1
Score level to Change Color:
Pg. 6-7
EW-30623-79
BOM
3/4" to 1/2" Polypro
reducing coupling
(PVS inlet) [McMaster]
3/8" NPT x 1/2" Barbed threaded
tank fitting [Eldon James]
Glycerin Tank - Barbed Tconnector (HDPE 1/2" x 1/2")
[Cole-Parmer]
1" NPT x 1/2" Barbed
threaded fitting for PVS
(Nylon) [McMaster]
Y connector [Eldon James]
BOM
Reducer 1 to 1/2 plastic (HDPE) into PVS/Reducer
3/4 to 1/2 plastic (HDPE) Out of PVS
[Cole-Parmer]
Glycerine Tank - Shut-off Valve
(1/2" to 1/2" barb)[Eldon James]
BOM
Biocompatible Valve
[Cole-Parmer]
Biocompatible
Non-valved
[Cole-Parmer]
BOM
10Qt [McMaster]
BOM
Dimensions:
43.9”L x 25.6” x 33.3”H
Weight:
42.55 lbs.
Sam’s Club
Pg.8
Blood Loop
Pg.9
Glycerin Loop
Pg.10 -12
Voltage
(pres s ure) at
the arterial
capacitor.
(V)
With
venous
capacitor
Without
venous
capacitor
Voltage
(pres s ure ) at Current(flow
the venous rate) in the
capacitor (V) loop(A)
Ris e time of
the arterial
capacitor
(s )
Ris e time of
the venous
capacitor
(s )
96.61
3.41
6.64
0.0403
0.0727
96.36
0
7.13
0.0403
0.0000
Pg. 13-14
Properties & Equations:
Assumptions:
The assumptions that were chosen for the
fluids analysis include:
•Laminar Flow
•Incompressible Flow
•Steady State
Summary:
• Using the assumptions listed above, the head losses associated with diameter changes,
connections and sections of tubing were analyzed
•The steady-state assumption at the desired flow rate (6 L/min) for the Physiological Loop
is assumed to be “worst-case” in regards to the head losses. The analysis proves that
there is adequate flow and pressure within the system to allow for adjustments to be
made through testing to compensate for the non-steady characteristics
Pg. 15-17
Blood Loop
Fluids Analysis Results (Q= 6L/min)
hlT = 12893.8 in2/s2
P VAD Out = 100 mmHg (1.93 psi)
P VAD In = 33.86 mmHg (0.65 psi)
∆P VAD = 66.14 mmHg (1.28 psi)
Pg. 18-21
Physiological Loop
Fluids Analysis Results (Q= 6L/min)
hlT = 12893.8 in2/s2
P VAD Out = 100 mmHg (1.93 psi)
P VAD In = 34.12 mmHg (0.65 psi)
∆P VAD = 65.88 mmHg (1.28 psi)
Pg. 22-25
Fb
Analysis:
2R
The bubble will reach its maximum velocity when the acceleration is zero:
mg
Fd
We calculated for a bubble of 0.5mm in radius. All the bubble
with smaller size will take more time to rise.
After calculation in Maple, we found that the time and
distance for that the bubble reach its maximum velocity are
negligible. So we can assume that the velocity of the bubble
is constant with the value V=Vmax=0.213m/s. As a result, the
traveled distance is represented as below:
The distance is in meters, and the time is in seconds.
BOM
Stainless Steel [Mopec]
Stainless Steel Lid [Mopec]
BOM
B-D Disposable Luer-Lock 5mL Syringe[Cole Parmer]
Stainless steel cannula (13 gauge luer-lock)
[Cole Parmer]
BOM
10 Qt: [McMaster]
Pg. 26-27
Screw-Plug Immersion Heater
304 SS, W/Temp Control, 120
Volt, 1000 Watts, 1" NPT
Parts From: McMaster-Carr
Submersible Pump
for Water PET Plastic
Housing, 1/40 hp, 115
VAC, 6' Cord
Pg. 26-27
Tank Dimensions: Ø = 4.875” x 5.5”
Ti
T∞
q”
Tw
Tb
r2
98oF
Tw =
= 310.15K
Tb = 70oF (room temperature) = 294.26K
Attempt w/ LCM (Lumped Capacitance Method)
r1
Ti
Pg. 26-27
Tank Dimensions: Ø = 4.875” x 5.5”
Tw
Tb
Tw = 98oF = 310.15K
Tb = 70oF (room temperature) = 294.26K
Attempt w/ LCM (Lumped Capacitance Method)
Results:
•Time for the blood loop to
heat less than 2 hours.
•Show temperature rise will
be less likely to damage the
blood.
BOM
Tygon 1/2" ID tubing (S-50-HL
Medical Grade) AAX00037
Tygon 7/8" ID tubing (S-50-HL
Medical Grade
BOM
Stepless ear clamps [Oetiker]
Double Snap-Grip Nylon Hose and
Tube Clamp[McMaster]
Pg.28-29
T∞=70oF
Ti=98oF
Tm=?
y
x
Pg. 498 equation 8.37
Properties and Equation
from Fundamentals of
Heat and Mass Transfer
6th editions
|<------L=50in------>|
Particular Solution
Assume Solution:
Solution
Homogenous:
Now:
Assume solution:
Pg. 28-29
Temperature drop v.s distance
295
294.8
Temperture(K)
294.6
294.4
6 (L/min)
3( L/min)
294.2
Total Distance
294
293.8
293.6
293.4
0
1
2
3
4
Distance (m)
5
6
7
Pg. 30
Automated - linear actuator
& stepper motor
combination
(Anaheim Automation)
Back Up Manual
Resistance
Competitively priced, high resolution digital
captive linear acutuators
• Linear force up to 22.5 lbs (100N)
• Linear step resolution of .001”, .002” and .004”
• Unipolar and bipolar coil constructions
• Fast, powerful and precise positioning
• Precision radial ball bearing design
• Industry standard frame size
• Customized designs available
Parallax BASIC Stamp 2
microcontroller
(to control stepper motor)
http://www.anaheimautomation.com/manuals/L010451%20%20TSMCA42%20Spec%20Sheet.pdf
http://www.parallax.com/Store/Microcontrollers/BASICStampProgrammin
gKits/tabid/136/CategoryID/11/List/0/SortField/0/Level/a/ProductID/294/De
fault.aspx
Pg.31
Arterial Tank: Acrylic
7.2in tall
8in OD
7.75in ID
Bottom & Top: Acrylic
9in OD
0.236 thickness
Bolts:
Steel Hex Nut (1/4"-20, 7/16” width, 5/32" height) x8
Washer: Stainless Steel x8
Silicon O-Ring x2
Barbed Hose Fitting (Stainless - pressure regulator hookup) (53505K72)
Quick-connect Air Hose fitting (3/8" NPT threaded)
Low-Pressure SS CaseGauge +/-1% Accuracy 4"
Dial, 1/4" NPT (McMaster)
Cole-Parmer
Pressure Regulator
Resistance Calculations

MeanArterial Pr essure  MeanVenousPr essure L
Pr essure
 m m Hg
R

Flow
CariacOutput L
min


Source: Berne R. etal Physiology 4th edition Mosby, St Louis 1998
Tank size Calculations
Complance C 
Vair=Volume of air in tank
dVfluid
dPfluid


Vtank  Atank h fluid
Pfluid  ghfluid

Vair
Pair
= density of fluid
Atank= Cross sectional area of tank
g=Acceleration due to gravity
Vtank=Volume of tank
C= Compliance
Pfluid=absolute pressure of fluid
Pair=absolute pressure of air
Source: University of
Virginia Article, Design
Initial testing of a mock
human circulatory loop to
test LVAD performance
Pg. 32
Pg. 33
• Saline Flush
Pg. 34
Sensitivity - 0.156V/liter
Resolution – 7.8mV
Flow sensor (Transducer+board digiflow-ext1 )
Specs
Resolution
Output format
Max measurement
Model's specs
1ml/min
-5V to 5V
Frequency
15kHz to 18MHz
(transmitter frequency)
Price
Don’t need to purchase
Pg.34
Sensitivity – 10mV/psi
Resolution – 36.1µV
Pressure Sensor (Omega PX26-005DV )
Specs
Model's specs
Output format
(@10V) 50mV
Price
$36.00
Pg. 35
Thermocouple. (Omega - KMQSS-020G-12)
Specs
Model's specs
Type
Ungrounded
Price
$28.65
S
1
2
3
4
5
6
7
8
9
10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Pg.35-36
Thermocouple DAQ (NI 9211A)
Specs
Resolution
Number input pins
Voltage range
Sampling rate
Price
DAQ (OMB-DAQ-54)
Specs
Resolution
Number input pins
Voltage range
Sampling rate
Price
Model's specs
22 bits (4.761µV/code)
10 single ended
Per Channel 31mV to 20V
80 S/sec
$649
Model's specs
24bit (9.54nV/code)
4
-80mV to 80mV
15 S/s (samples per secs)
$521
Pg.11
N
?More
needed ?
1
2
3
4
5
6
7
8
9
10
11
12
RISK
Dedicated DAQ system not within
budget
Instrumentation and DAQ not
communicating properly, DAQ does not
collect or output data properly
6
6
13
14
15
16