Coronary stenting: the appropriate use of FFR Morton J. Kern, MD Professor of Medicine Chief of Cardiology LBVA Associate Chief Cardiology University California Irvine Orange, California To treat or not to treat? Is this lesion producing Ischemia? Is PCI appropriate for situation? The rationale for using coronary physiology is the inability of the 2D images of angiogram to accurately depict the 3D lesion characteristics limiting flow. 75% Dia 20% Dia Uncertainty in Critical Angiographic Based Decisions • Intermediate Stenosis, no evidence ischemia • Left Main Stenosis • Multivessel CAD • Serial Lesions • Ostial and Branch Disease Measurement of FFR correlates to the results of stress testing and ischemia out of the lab. FFR is a ‘stress test’ for that artery in the lab at time of cath. Aortic, Pa FFR= Pd/Pa = 65/90 = 0.72 Coronary, Pd Resting pressures Adenosine 5 Steps to Accurate FFR 1. Zero guide and wire on table to atmosphere 2. Insert wire into guide and match wire/guide pressures in aorta 3. Cross lesion 2-3cm distal 4. Turn on IV adenosine 2-4 minutes 5. Confirm accuracy with pressure pull back Rely on FFR Avoid pitfalls of pressure and FFR Hemodynamic Artifacts: • Damped pressure waveforms. • Guide obstruction • Contrast media • Very small guide (<5F) • Pressure signal drift • Side holes and ostial ‘pseudostenosis’ Technical • loose connections • Improper zero • Calibration offset Anatomic • Extreme tortuosity • Inability to wire vessel • Spasm Mechanical Wire/artery impact Pharmacologic • Inadequate hyperemia Rely on FFR Effect of Wire Introducer Rely on FFR – No Guide Catheter Side Holes or Damping From Nico Pijls Rely on FFR – Avoid Signal Drift Drift Drift True Gradient Notch Notch No notch Notch Severe stenosis filters high frequency components – No dichrotic notch Notch No notch Distal wave form is one key to drift IV vs IC Pharmacologic Hyperemic agents Q: Why can we not use IVUS/OCT for functional assessment? A: A single cross-sectional area does not mean the same thing everywhere. 5 < 4 mm² = significant stenosis ? Ref Diam (mm) 4 3 2 50 25 % Stenosis for an Cross Sectional Area of 4 mm² 0 Single anatomic parameters do not predict FFR with confidence IVUS v FFR When can you NOT rely on FFR? False Negative FFR 1. Pressure Damping 2. No hyperemia - wrong drug, not mixed not delivered (IV?) or side holes 3. STEMI, culprit. STEMI – non-culprit OK 4. LM + LAD when FFRepicardial <0.6 5. Serial lesion FFR of individual lesion (only gradient useful) False Positive FFR 1. Technical errors (Pressure signal drift,zero, etc.) Coronary Physiologic (FFR) Criteria and Clinical Outcome Studies Application FFR Ischemia detection, >15 studies Pos <0.75 Neg >0.80 Deferred angioplasty, >8 studies (Key Study: Defer) >0.75 Multivessel FFR guided PCI, LM, Ostial, Jailed Side Branch >0.80 (Key Study: FAME I, II) (Key Study: Hamilos for LM) (Key Study: Koo BW et al) Endpoint of stenting *(IVUS better post stent) >0.94* 62 yo Man, RCA stent occl 2yr ago with return of CP LAD FFR=0.86, 0.87 Now 1V CAD and new approach DEFER Study – 5 year data JACC RW. 59 yo man with Angina, inferior perf defect 3V CAD – CABG vs PCI? FFR=0.71 2 Questions How Accurate is Stress Test? If PCI needed, FFR directed? JACC 2010;56:177 FAME study: Death and MI after 2 Years Tonino et al, NEJM 2009, Pijls et al, JACC 2010 Angio-guided FFR-guided % 10 12.7 P= 0.03 P= 0.03 8.4 9.5 6.1 5 Death or MI 0 2 year MI 2 year(exclusion of small periprocedural infarction) Fearon WF et al. Circ 2010;122:25450-2550 Cost Incremental Increm. Cost [$] [$] Economic Evaluation of FFR-guided PCI in pts with MVD. 5000 3000 2000 ROTO 1000 BMS -0.100 -0.075 -0.050 Balloon -0.025 CABG -1000 -3000 -4000 -5000 -6000 FFR Guidance Improves Outcomes FFR Guidance Improves outcomes DES 0 0.000 -2000 FFR Guidance FFR Guidance Saves Saves Resources Resources ICER of 50,000 $ / QALY 4000 0.025 0.050 0.075 0.100 Incremental Increm. QALY QALY Angiographic 3- or 2-Vessel Disease does NOT equal Physiologic 3- or 2V CAD FAME: Angiography vs FFR Tonino, P. A. L. et al. J Am Coll Cardiol 2010;55:2816-2821 3V CAD Angio = 14% physiol 2V CAD Angio= 43% physiol FAME II – Ischemia directed PCI+OMT vs OMT alone Stable patients scheduled for 1, 2 or 3 vessel DES stenting FFR in all target lesions Registry Randomised Trial At least 1 stenosis with FFR ≤ 0.80 When all FFR >0.80 Randomisation 1:1 PCI + OMT OMT OMT 50% randomly assigned to FU Follow-up after 1, 6 months, 1, 2, 3, 4, and 5 24years FAME II Rate of Any Revascularisation Cumulative incidence (%) 60 RCT:OMT vs. RCT:PCI+OMT = 12.1% vs. 1.7% 50 HR (95% CI): 7.63 (3.24-18.0); logrank p<.0001 40 30 20 10 RCT:PCI+OMT vs. REGISTRY:OMT, p=0.54 0 0 1 3 4 5 6 7 8 9 10 12 10 18 1 10 18 1 10 18 1 8 18 1 Months after randomisation No. at risk RCT:OMT only 339 RCT:PCI+OMT 352 REGISTRY:OMT only 131 2 238 256 88 123 144 41 119 141 40 115 140 40 112 139 40 83 114 35 20 25 4 25 71 yo Man with typical angina, pos stress, CAD risk factors What’s your best approach? FFR CFX FFR CFX=0.88 LAD Xience 3.5x18. 2nd LAD lesion? All done? ? FFR = 0.68 Physiologic Guidance 1. Appropriate need for Stents 2. Objective info re ischemia 3. Eliminates operator uncertainty Chest pain, No objective evidence ischemia Asymptomatic Patients FFR FFR FFR FFR FFR FFR FFR FFR FFR FFR FFR FFR FFR Revascularization Approaches per AUC 2v CAD with prox LAD 3v CAD Isolated LM LM and other CAD FFR reduces uncertainty and documents appropriateness The Mandate for Physiologic Guidance arises from a decade of outcomes studies and is supported by guidelines Class IA Guidelines - ESC Class IIa Guidelines - ACC/ AHA/ SCAI