Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348435 Investigation of the role of extracellular ATP and the P2X7 receptor in the modulation of immunosuppression within tumour microenvironment RF‐2011‐ 02351840 Defective Glucose Metabolism in Polycystic SAN RAFFAELE Milano Kidney Disease Defines a Novel Therapeutic Strategy: a Pre‐Clinical Proof‐of‐Concept Study RF‐2011‐ 02352006 Gender and geographical specific circulating microRNA signatures as biomarkers of atherosclerosis, atherosclerosis progression and vascular events MONZINO RF‐2011‐ 02348315 Defining the cis‐regulatory bases for variability in inflammatory gene expression in humans: a 3‐D analysis in the nuclear space I.E.O. RF‐2011‐ 02350693 To unravel the molecular basis of neurodevelopmental disorders CASA SOLLIEVO SOFFERENZA Emilia‐Romagna Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Immunology Oncology 5 Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 5 Vascular and Hematology Metabolism disorders and cardiovascular disease 5,5 Biomedical Genes, Genomes and Genetics Infection and immunity 5,5 Biomedical Genes, Genomes and Genetics Neurological diseases 5,5 Clinical Pagina 1 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02351092 "Detection of pathological prion protein in cerebrospinal fluid by real‐time quaking induced conversion (QuIC): Evaluation and standardization of a novel disease‐specific laboratory test for the diagnosis of sporadic Creutzfeldt‐Jakob disease." Ist.Sci. Neurologiche Bologna Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 6 RF‐2011‐ 02348358 Immune, procoagulant and inflammatory responses in severe sepsis and septic shock MAGGIORE Biomedical Immunology Infection and immunity 6 RF‐2011‐ 02347228 Altered host‐virus interaction as cause of multiple sclerosis: focus on Epstein‐Barr virus and antiviral immune response ISS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 6 RF‐2011‐ 02352291 Assessment of the macrophage role in the natural history of myeloproliferative neoplasms SAN RAFFAELE Milano Biomedical Oncology 1 ‐ Basic Translational Oncology 6,5 RF‐2011‐ 02352852 Dynamics and ultrastructure of stress sensing SAN RAFFAELE Milano Biomedical Cell Biology The new biotechnologies 6,5 RF‐2011‐ 02350836 New nano‐systems for targeted delivery of cytokines to tumors SAN RAFFAELE Milano Biomedical Oncology 2 ‐ Translational Clinical Oncology 6,5 RF‐2011‐ 02350857 Role of anoctamin‐1 in iodide transport and implications for the efficacy of radioiodine‐ based cancer therapy. Emilia‐Romagna Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Oncology 6,5 RF‐2011‐ 02346976 Identification of critical p53 co‐regulators and effectors during tumor suppression I.E.O. Biomedical Genes, Genomes and Genetics Oncology 6,5 AREA STRATEGICA SCORE. Pagina 2 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02350617 Determinants of Type 1 Diabetes (T1DM) clinical onset and progression in paediatric immigrant population RF‐2011‐ 02348466 DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 6,5 GENome‐wide association study to Evaluate MAGGIORE genetic risk factors for cerebral sinus‐ venous thromboSIS (GENESIS Study) Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 6,75 RF‐2011‐ 02349806 Mitochondrial targeting in LRRK2‐ associated parkinsonism (PARK8) SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 7 RF‐2011‐ 02350347 An integrated genomic, transcriptomic and epigenomic approach in multiplex multiple sclerosis families. SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics Neurological diseases 7 RF‐2011‐ 02349985 Production of novel diagnostic and therapeutic antibodies directed against stem cells in colorectal and lung cancer REGINA ELENA Biomedical Oncology 2 ‐ Translational Clinical Oncology 7 RF‐2011‐ 02351165 Translational genetics of hereditary spinocerebellar degenerations: high‐ throughput exome sequencing and model organisms for the identification and characterization of novel disease genes CARLO BESTA Biomedical Genes, Genomes and Genetics Neurological diseases 7 RF‐2011‐ 02351474 Dysregulated RNA metabolism in multiple myeloma SAN RAFFAELE Milano Biomedical Oncology 1 ‐ Basic Translational Oncology 7 RF‐2011‐ 02352582 N‐acetylcysteine in the treatment of neuropathic pain NEUROMED Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 7 Piemonte Pagina 3 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02352331 Systemic Sclerosis and Chronic Graft versus Host Disease: application of novel predictive assays and generation of transgenic animal models Marche Biomedical Immunology Infection and immunity RF‐2011‐ 02347869 CHANGES IN STRUCTURE AND RECRUITMENT OF MUSCLE SYNERGIES AFTER CORTICAL AND CEREBELLAR LESIONS SANTA LUCIA Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 7,25 RF‐2011‐ 02347691 Generation and functional characterization of artificial lymphoid organs with mutipotent stromal progenitors SAN RAFFAELE Milano Biomedical Biology of Development and Aging Oncology 7,25 RF‐2011‐ 02350689 Role of regulatory cells and cytokines in the extent of colonic involvement in patients with ulcerative colitis: implications for patient‐oriented therapy ISS Biomedical Digestive, Kidney and Urological Systems Infection and immunity 7,5 RF‐2011‐ 02346987 Development of a second generation PCR‐ Based Replicon Typing system to trace and control the antimicrobial resistance spread in Enterobacteriaceae ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 7,5 RF‐2011‐ 02347907 Enhanced cell therapy: novel strategies to improve transplanted cell survival and engraftment by protection from oxidative stress REGINA ELENA Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 7,5 RF‐2011‐ 02347253 Identification and validation of new therapeutic targets in Acute Myeloid Leukaemia I.E.O. Biomedical Oncology 1 ‐ Basic Translational Oncology 7,5 AREA STRATEGICA SCORE. 7 Pagina 4 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02348444 Inherited arrhythmias: clinical characterization, genetic geography and experimental studies in the Calabria Region isolate. MAUGERI Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 7,5 RF‐2011‐ 02347470 Regulation of mitotic transitions I.E.O. Biomedical Cell Biology Oncology 7,5 RF‐2011‐ 02352638 ADIPOSE‐DERIVED MESENCHYMAL STEM CELLS AS NEW MINIMALLY INVASIVE REGENERATIVE TREATMENT TO TARGET EARLY OSTEOARTHRITIS: FROM PRE‐CLINICAL PROCEDURE SELECTION TO CLINICAL APPLICATION IN A RANDOMIZED DOUBLE‐BLINDED CONTROLLED TRIAL RIZZOLI Clinical Musculoskeletal, Oral and Skin Sciences The new biotechnologies 7,5 RF‐2011‐ 02350228 Steroid myopathy: pathogenesis and prevention MAUGERI Biomedical Musculoskeletal, Oral and Skin Sciences Infection and immunity 7,5 RF‐2011‐ 02346867 The role of mechanobiology in establishment and progression of intima hyperplasia associated to vein coronary bypass grafts disease MONZINO Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 7,5 RF‐2011‐ 02350023 Evaluation of the potential application of bivalve shellfish as bioindicators of pollution for viral pathogens in coastal waters of southern Italy IZS Mezzogiorno Biomedical Veterinary Food safety and animal welfare 7,5 RF‐2011‐ 02350097 Skeletal muscle in Spinal and Bulbar Muscular Atrophy (SBMA): therapeutic target and delivery route for potential treatments Veneto Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 7,5 AREA STRATEGICA SCORE. Pagina 5 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02351229 Stress‐Activated Protein Kinases MLK3 and p38 as novel therapeutic targets in chemokine‐driven leukocyte extravasation and non‐resolving inflammatory processes SAN RAFFAELE Milano Biomedical Immunology Infection and immunity 7,5 RF‐2011‐ 02348796 ETHYL‐EICOSAPENTAENOIC ACID ADDED TO INTERFERON ß THERAPY IN RELAPSING‐REMITTING MULTIPLE SCLEROSIS: A RANDOMIZED PHASE II CLINICAL TRIAL. ISS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 7,5 RF‐2011‐ 02347946 An image‐analysis platform for automated in‐situ high‐content and resolution analysis of tumor heterogeneity: targeting genomic, epigenetic, and functional diversity in tissues by fluorescence microscopy I.E.O. Biomedical Bioengineering Sciences and Technologies Oncology 7,75 RF‐2011‐ 02347197 Epidrugs and cardiac differentiation: relevance for the 22q11.2 deletion syndrome NEUROMED Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 8 RF‐2011‐ 02349938 From Bench to Bedside: an Integrated Approach to RASopathies ISS Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 8 RF‐2011‐ 02347596 LEKTI, a multifunctional protein involved in skin desquamation and immunity: towards novel therapeutic approaches for rare and common skin diseases IDI Biomedical Musculoskeletal, Oral and Skin Sciences Infection and immunity 8 RF‐2011‐ 02351998 New Molecular Mechanisms of Leukemia Immune Evasion after Allogeneic Hematopoietic Stem Cell Transplantation SAN RAFFAELE Milano Biomedical Oncology 2 ‐ Translational Clinical Oncology 8 AREA STRATEGICA SCORE. Pagina 6 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02347120 Cell‐on‐chip technology as a novel tool to investigate the crosstalk between cancer and immune cells: role of the transcription factors Interferon Regulatory Factor 1 and 8 (IRF1, IRF8) in melanoma as a model system. ISS Biomedical Oncology 1 ‐ Basic Translational The new biotechnologies 8 RF‐2011‐ 02350485 NEUROSTEROIDS AS DETERMINANTS OF ANTIEPILEPTIC DRUG REFRACTORINESS IN TEMPORAL LOBE EPILEPSY Emilia‐Romagna Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 8 RF‐2011‐ 02350464 New self‐powered devices for cochlear stimulation based on piezoelectric nanomaterials Toscana Biomedical Bioengineering Sciences and Technologies The new biotechnologies 8 RF‐2011‐ 02347337 Dendritic cell‐based vaccine therapy in indolent non‐Hodgkin lymphoma patients: a phase I clinical study ISS Biomedical Oncology 2 ‐ Translational Clinical Oncology 8 RF‐2011‐ 02350993 Investigation of a novel engineered probiotic to treat Clostridium difficile infection SAN RAFFAELE Milano Biomedical Infectious Diseases and Microbiology Infection and immunity 8 RF‐2011‐ 02349126 Hypoxia, Inflammation and redox status as determinants of malignant progression of cancer stem cells SAN RAFFAELE Pisana‐ Roma Biomedical Oncology 1 ‐ Basic Translational Oncology 8 RF‐2011‐ 02348970 Structure and biology of the Tat/Env complex and role of anti‐Tat/Env antibodies in HIV infection: implication for HIV/AIDS preventative vaccine development ISS Biomedical AIDS and Related Research Infection and immunity 8 AREA STRATEGICA SCORE. Pagina 7 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02348476 ROLE OF THE NOVEL PRESYNAPTIC PROTEIN PRRT2 IN NEURONAL PHYSIOLOGY AND IN THE PATHOGENESIS OF PAROXYSMAL NEUROLOGICAL DISORDERS SAN RAFFAELE Milano Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases RF‐2011‐ 02351876 Vitamin D deficiency and obesity after kidney transplantation: multicenter study on gene‐environment interactions leading to "complex‐phenotypes" in a human system associated with cardiovascular events and graft rejection. Piemonte Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 8,5 RF‐2011‐ 02348684 Taking a step forwards the preparedness for IZS Piemonte, Liguria e preventing crises: Improving the molecular Valle d'Aosta detection of emerging pathogens in food. Biomedical Veterinary Food safety and animal welfare 8,5 RF‐2011‐ 02346754 Tie2 monocyte‐mediated delivery of IFN‐ SAN RAFFAELE Milano alpha into the liver as a novel treatment for colorectal carcinoma (CRC) liver metastases. Biomedical Oncology 2 ‐ Translational Clinical Oncology 8,5 RF‐2011‐ 02352379 Sensorimotor Integration. Physiology and Pathophysiology MAUGERI Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 8,5 RF‐2011‐ 02349712 Genomic complexity of chronic lymphocytic leukemia (CLL): clinicobiologc implications and pharmacoeconomic evaluation at the beginning of the kinase‐ targeted treatment era Emilia‐Romagna Clinical Oncology 2 ‐ Translational Clinical Oncology 8,5 RF‐2011‐ 02352318 Immunological Mechanisms Involved in The Pathogenesis of Primary Aldosteronism Veneto Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 8,5 AREA STRATEGICA SCORE. 8 Pagina 8 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02352308 ¿WHY ME?¿ PROJECT (WM?P). INVESTIGATING WHITE MATTER CONNECTIVITY IN SCHIZOPHRENIA AT IMAGING, CELLULAR, AND TRANSPOSONE LEVELS IN MONOZYGOTIC DISCORDANT TWINS MEDEA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 8,5 RF‐2011‐ 02349693 Vibrio and viruses in shellfish: old and emerging pathogens. Evaluation of exposure levels for the implementation ofprevention strategies. ISS Biomedical Veterinary Food safety and animal welfare 8,5 RF‐2011‐ 02349921 THE ROLE OF THE BRAIN‐ADIPOCYTE AXIS ACTIVITY IN POTENTIATING ANTIDEPRESSANT EFFICACY ISS Biomedical Biobehavioral and Behavioral Processes Neurological diseases 8,5 RF‐2011‐ 02346771 Does gut flora influence autoimmune responses in Multiple Sclerosis? The MAIT cell story. SANTA LUCIA Biomedical Immunology Infection and immunity 8,5 RF‐2011‐ 02347224 CCL2/CCR2 blocking:molecular insights into a potential therapeutic strategy against HIV replication ISS Biomedical AIDS and Related Research Infection and immunity 8,5 RF‐2011‐ 02347300 Specialized‐functionally connected membranes as caveolae and exosomes include molecular signature to decode melanoma progression mechanisms exploitable in clinical therapy ISS Biomedical Cell Biology Oncology 8,5 RF‐2011‐ 02350455 Electromagnetic guided in‐situ laser Toscana fenestration of endovascular endoprosthesis Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering Metabolism disorders and cardiovascular disease 8,5 AREA STRATEGICA SCORE. Pagina 9 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02349269 From protein‐protein interaction studies new potential therapeutic targets to treat the MLL‐related acute lymphoblastic leukemias SDN Biomedical Oncology 1 ‐ Basic Translational Oncology 8,5 RF‐2011‐ 02348164 CARDIOriGEN ‐ MicroRNAs inducing cardiac regeneration ‐ From discovery towards clinical application Friuli‐Venezia Giulia Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 8,5 RF‐2011‐ 02351158 Beta‐adrenoceptor antagonism and biased agonism in the control of pathological neovascularization ISS Biomedical Biological Chemistry and Macromolecular Biophysics Metabolism disorders and cardiovascular disease 8,5 RF‐2011‐ 02352088 Meeting senior members in the search for new associatesof the exclusive hamartromatous gene club Puglia Biomedical Digestive, Kidney and Urological Systems Oncology 8,5 RF‐2011‐ 02348346 A long ncRNA point‐of‐view to FSHD muscular dystrophy pathophysiology and therapeutics. SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics Neurological diseases 8,5 RF‐2011‐ 02349671 Exploring the role of the prokineticin system in experimental autoimmune encephalomyelitis: a preclinical study towards the definition of possible novel targets of therapy for human multiple sclerosis CARLO BESTA Biomedical Immunology Neurological diseases 9 RF‐2011‐ 02347362 Induced pluripotent stem cells (iPSCs) as a SAN RAFFAELE Milano tool to develop neuroprotective (autologous) neural stem cell‐based therapy in multiple sclerosis Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 9 AREA STRATEGICA SCORE. Pagina 10 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349717 A new therapeutic window in neurorehabilitation FATEBENEFRATELLI Biomedical Biobehavioral and Behavioral Processes Neurological diseases 9 RF‐2011‐ 02349251 INFLAMMATORY AND THROMBOCCLUSIVE VASCULOPATHY: THE ROLE OF PROTEINS RELATED TO COMPLEMENT ACTIVATION. C.R.O. AVIANO Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 9 RF‐2011‐ 02347490 Uncovering the molecular bases of the association of uromodulin common variants with hypertension and chronic kidney disease for the identification of novel therapeutic strategies SAN RAFFAELE Milano Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 9 RF‐2011‐ 02348839 Identification of therapeutic targets for neurological disorders: analysis of the mechanisms regulating cortical interneuronsdevelopment. SAN RAFFAELE Milano Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 9 RF‐2011‐ 02349698 Individual risk in clinically isolated syndromes of conversion to multiple sclerosis and disease progression: an integrated public health clinical genomics approach SAN RAFFAELE Milano Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 9 RF‐2011‐ 02347608 Clostridium difficile infection in Italy: do we know the true magnitude of the problem? SPALLANZANI Clinical Infectious Diseases and Microbiology Infection and immunity 9 RF‐2011‐ 02350972 MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF MECHANISMS INVOLVED IN IRON HOMESTASIS AND HEME SYNTHESIS IN ß THALASSEMIC ERYTHROPOIESIS MAGGIORE Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 9 Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 11 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347675 Radiation biodosimetry in emergency: validation of automated scoring and accuracy of dose prediction AOU San Martino‐IST ‐ Genova Biomedical Oncology 1 ‐ Basic Translational Diseases of environmental origin, with reference also to the workplace 9 RF‐2011‐ 02352111 Expression and function of P2 receptors in human psoriatic keratinocytes. Study of their role in psoriasis pathogenesis and research of new potential therapeutic targets Emilia‐Romagna Biomedical Musculoskeletal, Oral and Skin Sciences Infection and immunity 9 RF‐2011‐ 02350556 Low‐cost cardio‐pulmonary monitoring system for avoidable death prevention in the hospital general ward Piemonte Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 9 RF‐2011‐ 02350971 The role of early systematic best palliative IRST Meldola care versus on request palliative care consultation during standard oncologic treatment for patients with advanced gastric or pancreatic cancers: a randomized, controlled, multicenter trial Clinical Healthcare Delivery and Methodologies Oncology 9 RF‐2011‐ 02352131 GLP‐1 agonists treatment vs endoscopic procedures in obesity and type II diabetes mellitus management: a randomized clinical trial. Piemonte Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 9 RF‐2011‐ 02347971 Molecular regulation of the redox switch in inflamed skeletal muscle as a novel target to implement muscle regeneration and limit fibrosis in immune‐mediated myositis SAN RAFFAELE Milano Musculoskeletal, Oral and Skin Sciences Infection and immunity 9 Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 12 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02348151 Identification and manipulation of immunosuppressive networks in tumor microenvironment of patients undergoing immunobiological therapies. SAN RAFFAELE Milano Biomedical Immunology Oncology 9 RF‐2011‐ 02351216 Cortico‐cortical functional connectivity and recovery of post‐stroke spatial attention and awareness disorders SANTA LUCIA Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 9 RF‐2011‐ 02349556 Impact of asbestos‐mediated inflammation in mesothelioma genesis and progression. Implication for early diagnosis, prognosis and therapy HUMANITAS Biomedical Oncology 1 ‐ Basic Translational Oncology 9 RF‐2011‐ 02351149 Dominant optic atrophy (DOA) and OPA‐ thies in Italy (ITA‐DOA): minimal prevalence, genetics and phenotypes, and cell models of disease towards a therapy. Ist.Sci. Neurologiche Bologna Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 9 RF‐2011‐ 02351889 Eco‐epidemiology of Mycobacterium bovis infection in Mediterranean area: a multi‐ disciplinary approach. IZS Sicilia Biomedical Veterinary Infection and immunity 9 RF‐2011‐ 02347935 PRECLINICAL DEVELOPMENT OF THERAPEUTIC, ANTI‐BETA‐GLUCAN ANTIBODIES FOR UNIVERSAL PROTECTION AGAINST FUNGAL PATHOGENS ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 9 RF‐2011‐ 02347945 Caffeine as a potential therapeutic option for Alzheimer's disease ISS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 9 AREA STRATEGICA SCORE. Pagina 13 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02349393 Human Ewing Sarcoma Family Tumor (ESFT) Revisited From Cancer Stem Cells (CSCs) to the Epigenetic Regulation: cross‐ talk between ncRNA and DNA methylation Lombardia Biomedical Oncology 1 ‐ Basic Translational Oncology 9 RF‐2011‐ 02350769 Potential role of HDL Cholesterol Efflux Capacity in the evaluation of cardiovascular risk in patients with Familial Hypercholesterolemia (FH) AOU San Martino‐IST ‐ Genova Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 9 RF‐2011‐ 02346892 The low density lipoprotein‐associated protein prenylcysteine lyase: a novel player in atherosclerosis? MONZINO Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 9 RF‐2011‐ 02348166 Constitutive Axl signaling in human melanoma: role in tumor biology and in resistance to BRAFV600E inhibitors IST.TUMORI MILANO Biomedical Oncology 1 ‐ Basic Translational Oncology 9 RF‐2011‐ 02350853 Identification and validation of novel stem cell markers for the stratification of breast cancer patients. I.E.O. Biomedical Oncology 2 ‐ Translational Clinical Oncology 9 RF‐2011‐ 02347245 Development of an immunotherapeutic strategy for an effective therapeutic HPV vaccine ISS Biomedical Oncology 2 ‐ Translational Clinical Oncology 9 RF‐2011‐ 02346811 Towards a functional classification of human melanoma: dissecting the altered intracellular signaling profile by phosphoproteomics approaches IST.TUMORI MILANO Biomedical Oncology 1 ‐ Basic Translational Oncology 9 AREA STRATEGICA SCORE. Pagina 14 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351358 Dietary advanced glycation end products and cardiovascular risk: animal and human studies ISS RF‐2011‐ 02348236 CARPEDIEM ‐ Comorbidity And Risk Profiles Evaluation in Diabetes and hEart Morbidities Toscana RF‐2011‐ 02347084 Inflammation and oxidative stress in preeclampsia: role of the maternal endothelium and of the placenta, potential role in early markers development Lombardia RF‐2011‐ 02349663 Analysis of the possible pathogenic roles of the inflammosome and the microbiota in Alzheimer's disease RF‐2011‐ 02349068 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 9,25 Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 9,25 Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies 9,5 DON GNOCCHI Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 9,5 Development of in vitro insulin‐producing biohybrid organ for the cure of type 1 diabetes Umbria Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 9,5 RF‐2011‐ 02349321 Involvement of ADAR1‐ and ADAR2‐RNA‐ editing activity on myeloid leukemia and myeloid cell differentiation: novel future therapeutic implications. OSPEDALE BAMBINO GESU' Biomedical Oncology 1 ‐ Basic Translational Oncology 9,5 RF‐2011‐ 02349920 Dissecting the role played by mechanotransduction on Cardiac Stem Cell and cardiomyocyte dysfunction. Friuli‐Venezia Giulia Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 9,5 Clinical Pagina 15 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02348098 Phenotypic, functional and genomic SAN RAFFAELE Milano characterization of bone fragility in children and adolescents and their relatives: exploring the susceptibility to fractures in youth for its prevention in adulthood Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 9,5 RF‐2011‐ 02349653 Circulating endothelial progenitor cells as Toscana potential predictive and prognostic markers in metastatic colorectal cancer patients Biomedical Oncology 2 ‐ Translational Clinical Oncology 9,5 RF‐2011‐ 02348212 Developmental and genetic bases of Opitz G/BBB Syndrome towards better diagnosis and management of syndromic forms of intellectual disability BURLO GAROFALO Clinical Genes, Genomes and Genetics Neurological diseases 9,5 RF‐2011‐ 02348034 A Nationwide Clinical Study on the Role of Functional HLA‐DPB1 Matching in Unrelated Hematopoietic Stem Cell Transplantation SAN RAFFAELE Milano Clinical Oncology 2 ‐ Translational Clinical Oncology 9,5 RF‐2011‐ 02350832 Immune therapy with T regulatory type 1 (Tr1) cells in patients with type 1 diabetes undergoing islet transplantation SAN RAFFAELE Milano Biomedical Immunology Infection and immunity 9,5 RF‐2011‐ 02347806 The epigenetic basis of glioblastoma multiforme invasiveness and recurrence I.E.O. Biomedical Oncology 1 ‐ Basic Translational Oncology 9,5 RF‐2011‐ 02347187 Structural genomics/proteomics and solution characterization of proteins of biomedical interest: development of a comprehensive facility, application to therapeutic monoclonal antibodies, and to the fibrin(ogen)‐integrins cell‐matrix interactions model sy AOU San Martino‐IST ‐ Genova Biomedical Biological Chemistry and Macromolecular Biophysics Oncology 9,5 AREA STRATEGICA SCORE. Pagina 16 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347757 Risk assessment of occupational and environmental exposure to benzene and other chemicals at low doses: from molecular mechanisms to biological monitoring Campania Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 9,5 RF‐2011‐ 02351867 Ghrelin as a new cardiometabolic risk biomarker: from population studies to tissue and cell biology in skeletal muscle and heart. Friuli‐Venezia Giulia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 9,5 RF‐2011‐ 02350276 Novel multi‐analyte point‐of‐care testing device for rapid diagnosis and management of sepsis and severe infection. Toscana Biomedical Interdisciplinary Molecular Sciences and Training Infection and immunity 9,5 RF‐2011‐ 02352512 MicroRNA Signatures: Novel Biomarkers for early detection of Colorectal Cancer CASA SOLLIEVO SOFFERENZA Biomedical Oncology 2 ‐ Translational Clinical Oncology 9,5 RF‐2011‐ 02346966 Epigenetic signatures in human glioblastoma cells: implications for tumor biology and treatment AOU San Martino‐IST ‐ Genova Biomedical Oncology 1 ‐ Basic Translational Oncology 9,5 RF‐2011‐ 02348457 Regulatory mechanisms and therapeutic targeting of melanoma‐initiating cells Toscana Biomedical Oncology 1 ‐ Basic Translational Oncology 9,5 RF‐2011‐ 02351139 Phase IV clinical trial of anti‐viral treatment Sicilia for Hepatitis C infection in compensated cirrhosis Digestive, Kidney and Urological Systems Infection and immunity 9,5 RF‐2011‐ 02348309 EXtending Computational Analysis of functionaL Images to define the total asset of Bone marrow and hematopoietic fUnction in blood disoRdes (EXCALIBUR) Bioengineering Sciences and Technologies Oncology 9,5 AOU San Martino‐IST ‐ Genova Tipologia Clinical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 17 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348446 Long term mechanisms of diabetes prevention and remission after bariatric surgery: study of glucose metabolism, insulin secretion and cardiovascular risk 7 years after Roux‐en Y Gastric bypass. RF‐2011‐ 02352881 Development Of A Novel Adoptive Cell ISS Transfer Approach (ACT) For Cancer Immunotherapy Based On The Use Of Autologous IFN‐DC For The Induction Of Anti‐Tumor Response And Implemented By Strategies Aimed At Extending The Replicative Lifespan Of The Anti‐Tumo RF‐2011‐ 02352711 Search for new genetic biomarkers for early diagnosis and prevention of Familial Thoracic Aortic Aneurysms and Dissections Emilia‐Romagna RF‐2011‐ 02347071 Exploiting Immunoglobulin Stereotypy as a marker of prognosis and a target for therapy in Chronic Lymphocytic Leukemia SAN RAFFAELE Milano RF‐2011‐ 02347777 Molecular portrait of heterogeneous lesions throughout the course of bovine tuberculosis RF‐2011‐ 02347243 RF‐2011‐ 02349958 Tipologia AREA STRATEGICA SCORE. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Oncology 2 ‐ Translational Clinical Oncology 9,75 Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 9,75 Biomedical Oncology 1 ‐ Basic Translational Oncology 9,75 Sardegna Biomedical Infectious Diseases and Microbiology Infection and immunity 10 Genomic architecture and clonal evolution of myelodysplastic syndromes and myeloproliferative neoplasms SAN MATTEO Biomedical Oncology 1 ‐ Basic Translational Oncology 10 Engineering Commensal Bacteria for the Delivery of Therapeutic Proteins SAN RAFFAELE Milano Biomedical Bioengineering Sciences and Technologies Infection and immunity 10 Toscana Clinical Classificazione 1 Liv. Biomedical Clinical 9,5 Pagina 18 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350280 Genetic dissection of cystic fibrosis host susceptibility to Pseudomonas aeruginosa infections using a highly genetically diverse mouse resource population, the Collaborative Cross mice SAN RAFFAELE Milano Biomedical Infectious Diseases and Microbiology Infection and immunity 10 RF‐2011‐ 02347758 Reverse transcriptase inhibitors in an innovative anticancer therapy ISS Biomedical Oncology 1 ‐ Basic Translational Oncology 10 RF‐2011‐ 02350980 Disruption of white matter integrity in bipolar disorder: changes of diffusion tensor imaging measures as markers of the biological underpinnings of the progressive deterioration of cognition and of the cognitive control of emotions. SAN RAFFAELE Milano Brain Disorders and Clinical Neuroscience Neurological diseases 10 RF‐2011‐ 02349918 Searching for early and predictive markers of individual risk for head and neck cancer Toscana Biomedical Oncology 1 ‐ Basic Translational Oncology 10 RF‐2011‐ 02347970 Optimization of plasma progranulin dosage FATEBENEFRATELLI for predicting null progranulin mutations in neurodegenerative diseases: A pilot Multicentre Italian Study for harmonization of procedures to be translated into clinical practice. Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 10 RF‐2011‐ 02350246 Improving social dysfunction through oxytocin administration in non‐human infants exposed to maternal neglect early during postnatal life Biomedical Biobehavioral and Behavioral Processes Neurological diseases 10 ISS Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 19 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02351875 IMPACT OF EXPOSURE TO ESTROGEN‐ LIKE ENDOCRINE DISRUPTING CHEMICALS(EEDC) ON PUBERTAL DEVELOPMENT AND ESTABLISHMENT OF REFERENCERANGES FOR EXPOSITION IN CHILDHOOD. OSPEDALE BAMBINO GESU' Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diseases of environmental origin, with reference also to the workplace 10 RF‐2011‐ 02349297 Genetic factors influencing early plasma ribavirin cut‐off values in HCV therapy to reduce anemia toxicity and improve outcome. Piemonte Biomedical Infectious Diseases and Microbiology Infection and immunity 10 RF‐2011‐ 02347141 Effect of Ag nanoparticles in controlling Salmonella and Campylobacter in laying hens and clinical and food safety insights IZS Venezie Biomedical Veterinary Food safety and animal welfare 10 RF‐2011‐ 02348959 From the measure of guidelines adherence in oncology to the assessment of health system performance Lombardia Clinical Healthcare Delivery and Methodologies Oncology 10 RF‐2011‐ 02348951 Innate immune response as a key factor aimed to optimize HCV patients therapy management SPALLANZANI Biomedical Immunology Infection and immunity 10 RF‐2011‐ 02350484 Tumor Infiltrating Lymphocytes (TIL) and melanoma: prognostic markers and new terapeutic targets IDI Biomedical Oncology 1 ‐ Basic Translational Oncology 10 RF‐2011‐ 02346880 Targeted next generation sequencing as tool for molecular diagnosis of rare anemias Campania Biomedical Genes, Genomes and Genetics The new biotechnologies 10 AREA STRATEGICA SCORE. Pagina 20 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02348801 THE ROLE OF SOD1 IN THE NUCLEUS: NEW INSIGHTS INTO THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) MONDINO Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 10 RF‐2011‐ 02351616 Combining Unconventional T cells with Vaccination in Renal Cell Carcinoma Immunotherapy Puglia Biomedical Oncology 2 ‐ Translational Clinical Oncology 10 RF‐2011‐ 02352155 modulation of HCN channels by GPR35 in chronic pain Toscana Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 10 RF‐2011‐ 02352126 DEVELOPMENT OF NOVEL ANTIBODY‐ Veneto ENGINEERED GOLD NANOPARTICLES AS TARGETED DRUG DELIVERY FOR THE TREATMENT OF CHRONIC LUNG ALLOGRAFT DYSFUNCTION Biomedical Bioengineering Sciences and Technologies The new biotechnologies 10 RF‐2011‐ 02347986 A NEW STRATEGY FOR THE CONTROL OF RHEUMATOID ARTHRITIS: DUAL ROLE OF THE ATYPICAL CHEMOTACTIC RECEPTOR CCRL2 AS A BIOMARKER AND THERAPEUTIC TARGET HUMANITAS Biomedical Immunology Infection and immunity 10 RF‐2011‐ 02348348 From lifestyle to mitochondrial benefits: study on a combined therapeutic approach to Huntington's disease ISS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 10 RF‐2011‐ 02348364 New biomarkers for early SIRS/sepsis diagnosis in pediatric and adult patiens. Friuli‐Venezia Giulia Infectious Diseases and Microbiology Infection and immunity 10 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 21 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02346886 Novel formula milks and neonatal gut microbiota: a dynamic interplay approached by systems biology OSPEDALE BAMBINO GESU' RF‐2011‐ 02348953 A Twist code of p53 inactivation in sarcomas: clinicopathological and therapeutic implications C.R.O. AVIANO RF‐2011‐ 02351116 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Food safety and animal welfare 10 Clinical Oncology 1 ‐ Basic Translational Oncology 10 NEW ALLOCATION CRITERIA FOR LIVER Emilia‐Romagna TRANSPLANTATION IN PATIENTS WITH AND WITHOUT HEPATOCELLULAR CARCINOMA BASED ON TRANSPLANT BENEFIT PRINCIPLES: A MULTICENTER, PROSPECTIVE STUDY. Clinical Healthcare Delivery and Methodologies Oncology 10 RF‐2011‐ 02348194 Innovative diagnostic approach for hereditary cardiomyopathies MULTIMEDICA Clinical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 10 RF‐2011‐ 02352753 MOLECULAR CHARACTERIZATION OF COXIELLA BURNETII FROM DOMESTIC RUMINANTS AND WILDLIFE SPECIES BY MLVA AND NGS TECHNIQUES IZS Mezzogiorno Biomedical Infectious Diseases and Microbiology The new biotechnologies 10 RF‐2011‐ 02347276 Investigating the molecular mechanisms leading to genome instability in tumours: analysis of role of the replicationstress response and its potential for early diagnosis and target therapy of cancer ISS Biomedical Oncology 1 ‐ Basic Translational Oncology 10 RF‐2011‐ 02350889 Prospective Characterization of Circulating Tumor Cells in Patients with Hormone Receptor Positive Metastatic Breast Cancer I.E.O. Oncology 2 ‐ Translational Clinical Oncology 10 Clinical Pagina 22 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350578 IDENTIFICATION OF EPILEPTOGENIC NETWORKS IN SURGICAL EPILEPSIES BY A NON‐INVASIVE MULTIMODAL APPROACH CARLO BESTA RF‐2011‐ 02349798 Epithelial ovarian cancer: affecting tumor growth by targeting aberrant metabolism. IST.TUMORI MILANO RF‐2011‐ 02346750 The extracellular matrix protein EMILIN1 as C.R.O. AVIANO a novel structural and functional determinant of lymphangiogenesis and lymphedema RF‐2011‐ 02347603 Nationwide study on trends in hospital admissions for major cardiovascular events and procedures among people with and without diabetes in Italy, 2001‐2010 Piemonte RF‐2011‐ 02352383 Effects of Tumor‐associated Fibroblast and hypoxia on the availability of efficient NK cells within the tumor core: characterization of molecular targets for therapy in melanoma and colon cancer. AOU San Martino‐IST ‐ Genova RF‐2011‐ 02347260 In vivo toxi‐omic signatures for brain and thyroid function: combined exposure to mixtures of endocrine disruptingchemicals and iodine deficiency in animal models and translation to epidemiological/clinical studies ISS RF‐2011‐ 02347402 Non‐invasive assessment of liver steatosis and fibrosis in pediatric patients SAN MATTEO Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Brain Disorders and Clinical Neuroscience Neurological diseases 10 Biomedical Oncology 2 ‐ Translational Clinical Oncology 10 Biomedical Vascular and Hematology Oncology 10 Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 10 Biomedical Immunology Oncology 10 Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diseases of environmental origin, with reference also to the workplace 10 Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 10 Clinical Pagina 23 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350598 MicroRNA Signature of Vascular Complications in Type 1 Diabetes RF‐2011‐ 02351315 HPV positive oropharyngeal cancer: SAN MATTEO characterization of immunological and viral profiles, and their role in the response to treatment RF‐2011‐ 02347283 Breast cancer with low risk of local Emilia‐Romagna recurrence: 3D Conformal Accelerated and Hypofractionated Partial Breast Irradiation vs. standard whole breast radiotherapy after conservative surgery RF‐2011‐ 02351432 The complement and coagulation systems as therapeutic targets in subarachnoid hemorrhage: studies in patients and in experimental models. MAGGIORE RF‐2011‐ 02347262 RESPONSE ORIENTED MAINTENANCE IMMUNOTHERAPY IN PATIENTS WITH FOLLICULAR LYMPHOMA. Emilia‐Romagna RF‐2011‐ 02347359 Comparative analysis of genomic and epigenomic alterations induced by leukemogenic AML1‐fusion proteins I.E.O. RF‐2011‐ 02347522 Genetic markers in elderly to estimate the risk for vascular diseases by using the peripheral arterial disease model. Sicilia Piemonte Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 10 Clinical Oncology 2 ‐ Translational Clinical Oncology 10 Clinical Oncology 2 ‐ Translational Clinical Oncology 10 Brain Disorders and Clinical Neuroscience Neurological diseases 10 Oncology 2 ‐ Translational Clinical Oncology 10 Biomedical Oncology 1 ‐ Basic Translational Oncology 10 Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease Biomedical Clinical 10,25 Pagina 24 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347553 A phase II, randomised, placebo‐ controlled trial of neuroprotection with Raltegravir in Secondary Progressive Multiple Sclerosis ISS RF‐2011‐ 02350801 Implementation of Chronic Care Model, using Tele‐care and Home care, in patients with multiple comorbidities: evaluation of the cost‐effectiveness and quality of life Toscana RF‐2011‐ 02347532 A multi‐site international RCT comparing regional and general anesthesia in infants for effects on neurodevelopmental outcome at five year of age: The GAS Trial. GASLINI RF‐2011‐ 02350214 Tipologia AREA STRATEGICA SCORE. Brain Disorders and Clinical Neuroscience Neurological diseases 10,25 Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 10,25 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 10,5 Muscle imaging in neuromuscular STELLA MARIS disorders: conventional, high and ultrahigh field imaging studies for coming into a focus Biomedical Bioengineering Sciences and Technologies The new biotechnologies 10,5 RF‐2011‐ 02351947 The molecular basis of cognitive impairment in Williams‐Beuren Syndrome: a cell reprogramming‐based approach CASA SOLLIEVO SOFFERENZA Biomedical Genes, Genomes and Genetics Neurological diseases 10,5 RF‐2011‐ 02347422 Naturally occurring and re‐programed cancer stem cells in ovarian carcinoma: functional role and clinical implications. I.E.O. Biomedical Oncology 1 ‐ Basic Translational Oncology 10,5 RF‐2011‐ 02352440 Autonomic cardiovascular evaluation in low MAGGIORE respiratory tract infections Biomedical Cardiovascular and Respiratory Sciences Infection and immunity 10,5 RF‐2011‐ 02352328 Assessing colorectal cancer risk: are DNA viruses and genetic damage in circulating cells valuable biomarkers? Biomedical Oncology 1 ‐ Basic Translational Oncology 10,5 Emilia‐Romagna Biomedical Classificazione 1 Liv. Pagina 25 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347127 Genomic approach for motor neuron diseases SAN RAFFAELE Milano Clinical RF‐2011‐ 02350439 TRAIL‐producing UC‐MSCs as cytotherapy to defeat multiple myeloma: a preclinical study. ONCOLOGICO DI BARI RF‐2011‐ 02350623 Paratuberculosis in sheep and goats herds in Calabria and human exposure to Mycobacterium avium subspecies paratuberculosis (MAP) trough dairy products IZS Mezzogiorno RF‐2011‐ 02347060 Classificazione 1 Liv. AREA STRATEGICA SCORE. Brain Disorders and Clinical Neuroscience Neurological diseases 10,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 10,5 Biomedical Veterinary Food safety and animal welfare 10,5 Surveillance of the circulation of rotaviruses Sicilia in the infantile population of Sicily following the introduction of rotavirus vaccination Biomedical Infectious Diseases and Microbiology Infection and immunity 10,5 RF‐2011‐ 02350640 Investigation on the sensitivity of dorsal raphe serotonergic neurons to hypercapnic stimuli in a transgenic mouse model of Sudden Infant Death Syndrome (SIDS) characterized by selective alteration of serotonergic neuron autoinhibition. Toscana Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 10,5 RF‐2011‐ 02352520 Project Title: Endoscopic Screening and onCologic appropRiate rEmoval of Early colorectal lesioNs. ENDOSCREEN Piemonte Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 10,5 RF‐2011‐ 02348282 Studying the tumor microenvironment to find new therapeutic targets and strategies in Hodgkin lymphoma:the role of Mesenchymal stem cells C.R.O. AVIANO Biomedical Oncology 1 ‐ Basic Translational Oncology 10,5 Pagina 26 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350613 High‐throughput mutation profiling of Sézary Syndrome: implications for pathogenesis, classification, and potential therapeutic developments. IDI Biomedical Oncology 1 ‐ Basic Translational Oncology 10,5 RF‐2011‐ 02352036 METABOHEARTFAIL‐GRAPE miRNAs IN REVERSING REMODELING THROUGH MODULATION OF CARDIAC AQUAPORIN‐7 AND GLYCEROL UPTAKE IN A SWINE MODEL OF NON‐ISCHEMIC CHRONIC HEART FAILURE Toscana Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 10,5 RF‐2011‐ 02349080 Brain Mechanisms of Chronic Subjective Dizziness SANTA LUCIA Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 10,5 RF‐2011‐ 02346764 TRIMming away HIV‐1. infection Role of TRIM proteins in establishement and maintenance of HIV‐1 latency SAN RAFFAELE Milano Biomedical AIDS and Related Research Infection and immunity 10,5 RF‐2011‐ 02351656 GISSI Outliers ‐ The CAPIRE (Coronary Atherosclerosis in outlier subjects: Protective and Individual Risk factor Evaluation) study ‐ The Life Style sub‐study MAUGERI Biomedical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease 10,5 RF‐2011‐ 02346871 Exploiting neural stem cell‐targeted mouse SAN RAFFAELE Milano models for improving the understanding of the pathogenetic mechanisms underlying Tuberous Sclerosis Complex and developing novel therapeutic approaches. Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 10,5 RF‐2011‐ 02347571 Cell senescence and age‐dependent decrease in heart function: role of HMGB1 protein Biomedical Biology of Development and Aging Metabolism disorders and cardiovascular disease 10,5 IDI Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 27 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352686 Understanding Pancreatic Acinar Cell Carcinoma for better understanding Pancreatic Ductal Carcinoma SAN RAFFAELE Milano RF‐2011‐ 02346990 Development of a service interface method ( WebService) beetween family care physicians operating in a primary care setting and nephrologists , for the prevention, diagnosis and treatment of kidney damage in patients with type II diabetes mellitus . Toscana RF‐2011‐ 02351728 Containment of a region‐wide outbreak of Carbapenem‐resistant Klebsiella pneumoniae in seven lombardian hospital: molecular characterization, epidemiology and outcome. Lombardia RF‐2011‐ 02349240 Dynamics of epigenetic landscape during phase‐specific colorectal cancer reprogramming of stem cells and tissues in a murine stress related carcinogenesis model and human tumor biopsies. CASA SOLLIEVO SOFFERENZA RF‐2011‐ 02349381 MicroRNAs regulated by mutated p53 oncoproteins in colon cancer REGINA ELENA RF‐2011‐ 02347753 Genetic manipulation of embryonic stem NEUROMED cells and induced pluripotent stem cells (ES and iPS) for endorsing cardiac fate toward beating cardiomyocytes: novel strategies for cardiac regeneration in myocardial infarction. Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 1 ‐ Basic Translational Oncology 10,5 Clinical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 10,5 Clinical Infectious Diseases and Microbiology Infection and immunity 10,5 Biomedical Oncology 1 ‐ Basic Translational Oncology 10,5 Biomedical Oncology 1 ‐ Basic Translational Oncology 10,5 Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 10,5 Pagina 28 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02347686 Food safety of bivalve molluscs: Development and application of molecular tools for identification, quantification and evaluation of antibiotic resistance and virulence potential of food‐associated enteric and autochthonous bacterial pathogens RF‐2011‐ 02350566 DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Veterinary Food safety and animal welfare 10,5 MicroRNA regulation in the pathogenesis of FATEBENEFRATELLI MD and in the mechanism of action of antidepressant drugs Biomedical Biobehavioral and Behavioral Processes Neurological diseases 10,5 RF‐2011‐ 02347244 Dissecting the genetic etiology of epileptic encephalopathies by high‐throughput sequencing GASLINI Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 10,5 RF‐2011‐ 02350571 Heterotypic interactions in thrombo‐ inflammatory processes associated with the thrombotic vascular occlusion in sepsis:the role of vitamin K‐dependent protein C SAN RAFFAELE Milano Biomedical Immunology Infection and immunity 10,5 RF‐2011‐ 02347340 Pre‐clinical evaluation of safety and efficacy of intra‐arterial infusion of mesenchymal stems cells in experimental models ofneurodegenerative parkinsonisms and analysis of potential therapeutic mechanisms: en route for a clinical trial MONDINO Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 10,5 RF‐2011‐ 02346822 One or more beta‐amyloids? Links between amyloid composition and phenotypic heterogeneity in Alzheimer's disease: implications for diagnosis and therapy CARLO BESTA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 10,5 IZS Umbria e delle Marche Pagina 29 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02348713 Genetic variability of Mycobacterium tuberculosis and its implications for transmission dynamics, pathogenesis and immune response SPALLANZANI Clinical Infectious Diseases and Microbiology Infection and immunity 10,5 RF‐2011‐ 02347356 PHARMACOGENOMICS OF HYPERTENSION: A NEW APPROACH FOR A PERSONALIZED MEDICINE SAN RAFFAELE Milano Clinical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 10,5 RF‐2011‐ 02348075 Regulation of SMN2 splicing: implications for novel therapeutic approaches to Spinal Muscular Atrophy SANTA LUCIA Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 10,5 RF‐2011‐ 02347365 From breast to brain: study of the molecular mechanisms mediating the development of brain metastasis I.E.O. Biomedical Oncology 1 ‐ Basic Translational Oncology 10,5 RF‐2011‐ 02352809 Role of mast cells in the pathogenesis of diabetic heart disease. SAN RAFFAELE Milano Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 10,5 RF‐2011‐ 02346983 Investigation on the role of iron and mitochondria in neurodegenerative disorders through the development of new human neuronal cellular systems CARLO BESTA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 10,5 RF‐2011‐ 02346800 A new predictive assay to assess the efficacy of combinatorial treatments against stem cells enriched cultures from metastatic melanoma patients PASCALE Biomedical Oncology 1 ‐ Basic Translational Oncology 10,5 RF‐2011‐ 02349138 Rethinking neuroinflammation in sporadic AD: exploring novel pathways to boost endogenous neuroprotective mechanisms ISS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 10,5 AREA STRATEGICA SCORE. Pagina 30 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02352191 Structural imaging in systemic amyloidosis: an inescapable step toward the optimization and validation of more effective therapeutic approaches RF‐2011‐ 02349156 DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Biological Chemistry and Macromolecular Biophysics Metabolism disorders and cardiovascular disease 10,5 DEVELOPMENT OF AN EXOSOME BASED IZS Piemonte, Liguria e IN‐VIVO TEST TO DETECT PRIONS IN Valle d'Aosta BLOOD Biomedical Veterinary Food safety and animal welfare 10,5 RF‐2011‐ 02350708 Development of miniaturized assays for the Piemonte timely diagnosis of rare diseases Biomedical Musculoskeletal, Oral and Skin Sciences The new biotechnologies 10,75 RF‐2011‐ 02349089 Rescue of Transforming‐Growth‐Factor‐ OASI MARIA S.S. beta 1 signaling as a new strategy for neuroprotection in Alzheimer's disease: role of antidepressant drugs Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 10,75 RF‐2011‐ 02347827 Unravelling the genetic basis of variable clinical expression in NF1: use of an integrated next generation sequencing platform to identify novel disease‐causing and modifier genes. CASA SOLLIEVO SOFFERENZA Biomedical Genes, Genomes and Genetics Oncology 10,75 RF‐2011‐ 02349204 MITOCHONDRIA AND AUTOPHAGY IN DEGENERATIVE SYNAPSES SANTA LUCIA Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 10,75 RF‐2011‐ 02346959 Evaluation of the efficacy of Rapamycin and a DPP‐4 inhibitor (Vildagliptin) in improving beta cell function in type 1 diabetes of long duration, a perspective randomized study SAN RAFFAELE Milano Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease SAN MATTEO 11 Pagina 31 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352442 Long¿term exposure to ambient air pollution and pregnancy outcomes in women of three large Italian longitudinal studies RF‐2011‐ 02351880 Evaluation of anti‐NA antibodies as possible ISS correlates of protection from influenza disease: development of serological assays designed to detect a truly functional antibody response to influenza vaccination, with specific regard to the anti‐NA RF‐2011‐ 02347399 Senescence‐Associated microRNAs (SAmiRs) in cellular senescence and organismal aging RF‐2011‐ 02348370 Tipologia AREA STRATEGICA SCORE. Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 11 Biomedical Immunology Infection and immunity 11 SDN Biomedical Biology of Development and Aging Neurological diseases 11 Postural sway and facial mimicry as behavioral markers of covert motor symptoms in Parkinson's disease in a new differential early diagnostic protocol. SANTA LUCIA Biomedical Biobehavioral and Behavioral Processes Neurological diseases 11 RF‐2011‐ 02349811 The use of top soils improvers from municipal wastewater treatment plants, on pasture: risk assessment of the associated microbial and organic chemical contamination on grazing food producing animals, and on food safety and food security (SOIL‐SAFE) ISS Biomedical Veterinary Food safety and animal welfare 11 RF‐2011‐ 02351113 Fighting impaired blood flow and supporting skeletal muscle regeneration in diabetes and peripheral artery disease (PAD): an approach based on unacylated ghrelin (UAG) administration Piemonte Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 11 Lazio Clinical Classificazione 1 Liv. Pagina 32 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02350906 'Septosomes': System Biology and Pathogenetic Role of Exosomes in Sepsis‐ associated Immune‐paralysis and Organ Failures Piemonte Biomedical Immunology Infection and immunity 11 RF‐2011‐ 02350875 Use of Limbal Adult Stem Cells for Osteo and Condrocyte Differentiation and Application in Bone and in Cartilage Regeneration and Tissue Engineering (ABADIR PROJECT) Sicilia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies 11 RF‐2011‐ 02351077 Dissecting the pathogenesis and possible reversibility of cachexia in end‐stage chronic heart failure Sicilia Biomedical Musculoskeletal, Oral and Skin Sciences Metabolism disorders and cardiovascular disease 11 RF‐2011‐ 02346917 Transcriptomic profiling in circulating mesenchymal stem cells of patients with degenerative diseases. Veneto Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 11 RF‐2011‐ 02348826 Fertility preservation in gonadotoxic treatments Emilia‐Romagna Oncology 2 ‐ Translational Clinical Oncology 11 RF‐2011‐ 02350733 Co‐transcriptional and post‐transcriptional regulation of gene expression by EWS and EWS‐FLI1 in the pathogenesis of Ewing's Sarcoma SANTA LUCIA Biomedical Oncology 1 ‐ Basic Translational Oncology 11 RF‐2011‐ 02346984 Identification of new therapeutical targets of cancer stem cells: study of the mechanistics of mitotic spindle alignment to cortical polarity in mammary stem cell asymmetric divisions I.E.O. Biomedical Biological Chemistry and Macromolecular Biophysics Oncology 11 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 33 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02350341 Early treatment of exercise‐induced pulmonary hypertension in systemic sclerosis Toscana Clinical Immunology Infection and immunity 11 RF‐2011‐ 02346986 TRAIL receptor embedding in membrane rafts could predict cancer cell susceptibility to TRAIL‐based molecularly targeted therapy ISS Clinical Oncology 2 ‐ Translational Clinical Oncology 11 RF‐2011‐ 02349088 A translational approach to hereditary neuropathies AOU San Martino‐IST ‐ Genova Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 11 RF‐2011‐ 02347873 Cord blood expanded endothelial progenitors in patients with no‐option critical limb ischemia. Lazio Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 11 RF‐2011‐ 02350673 Screening for Autoimmune Polyglandular Syndrome Type 2 in patients with autoimmune thyroiditis: definition of methodology and cost‐benefit analysis. Toscana Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Infection and immunity 11 RF‐2011‐ 02350488 Imaging the fate of stem cells in vivo by near infrared technology: a translational study for longitudinal tracking in a rodent model of Parkinsons disease AUXOLOGICO Biomedical Emerging Technologies and Training in Neurosciences The new biotechnologies 11 RF‐2011‐ 02347867 Treatment of therapy‐refractory cancer in patients affected by Swachman Diamond syndrome or related inherited diseases due to alterations of the ribosomal apparatus. SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics Oncology 11 AREA STRATEGICA SCORE. Pagina 34 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347616 The role of CRPs and SIRTs in modulating cellular stress response after myocardial infarction. SAN RAFFAELE Pisana‐ Roma Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 11 RF‐2011‐ 02350999 Early identification of left ventricular dysfunction due to anthracyclines and target‐therapy: role of novel imaging techniques and microRNA. PASCALE Biomedical Cardiovascular and Respiratory Sciences Oncology 11 RF‐2011‐ 02346770 Clinical and healthcare strategies for improving quality of life in persons affected by spinal cord injuries: Tuscany regionalnetwork and use of innovative technological devices Toscana Healthcare Delivery and Methodologies Neurological diseases 11 RF‐2011‐ 02349125 Follow up study of the relationship between I.N.R.C.A. telomere length and the onset of diabetic complications Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 11 RF‐2011‐ 02351193 NETWORK DEGENERATION IN MOTOR NEURON DISEASES (MND): A STUDY OF THE STRUCTURAL AND FUNCTIONAL CONNECTOMES IN AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MND Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 11 RF‐2011‐ 02349948 Investigation of genetic molecular NEUROMED mechanisms underlying the risk of cardiovascular events: role of rs5065 human atrial natriuretic peptide gene variant Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 11 RF‐2011‐ 02347894 A new vaccine design to eliminate CCR5 expression and prevent HIV infection Biomedical AIDS and Related Research Infection and immunity 11 SAN RAFFAELE Milano SAN RAFFAELE Milano Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 35 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351863 Identification of Determinants of Healthy Aging in Italy (IDAGIT) CARLO BESTA RF‐2011‐ 02347242 Enhancement of NKG2D ligands‐induced anti‐tumor response in Hodgkin and non Hodgkin lymphomas: ERp5 thiol isomerase and ADAM10 disintegrin‐metalloproteinase as possible therapeutic targets. SAN RAFFAELE Milano RF‐2011‐ 02349443 Integrated diagnostic evaluation of PET/RM SDN and molecular markers in the diagnosis of bone lesions RF‐2011‐ 02348984 Next Generation Sequencing (NGS): from basic research to diagnostic tool for nephrotic syndrome. Puglia RF‐2011‐ 02350615 Characterization of the role of Mycobacterium avium subspecies paratuberculosis (Map) as a trigger in Type 1 Diabetes RF‐2011‐ 02352834 RF‐2011‐ 02347169 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 11 Immunology Oncology 11 Oncology 2 ‐ Translational Clinical Oncology 11 Biomedical Genes, Genomes and Genetics The new biotechnologies 11 Sardegna Biomedical Infectious Diseases and Microbiology Infection and immunity 11 Development and evaluation of Influenza Virus Polymerase Inhibitors for combination antiviral therapy ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 11 MECHANISMS REGULATING DENDRITIC CELL PROTUMORAL ACTIVITY WITHIN THE HYPOXIC MICROENVIRONMENT: POTENTIAL THERAPEUTIC APPLICATIONS IN NEUROBLASTOMA GASLINI Biomedical Oncology 1 ‐ Basic Translational Oncology 11 Biomedical Clinical Pagina 36 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347908 Prospective validation of predictive biomarkers in elderly patients with non‐ small‐cell lung cancer PASCALE RF‐2011‐ 02352056 A randomized intervention study to assess the effect of the Mediterranean Diet on the plasma fatty acid profile. MONZINO Clinical RF‐2011‐ 02349412 Modulation of the metabotropic glutamate receptor 1 as a novel strategy to treat nephrotic syndrome. MAGGIORE Biomedical RF‐2011‐ 02346763 Positive selection, expansion and transplantation of regulatory T cells (Tregs) to prevent cellular rejection and to induce tolerance in solid organ transplantation. Emilia‐Romagna RF‐2011‐ 02348235 Molecular pathologies and functional interactions of the CDKL5 and MECP2 genes involved in a large spectrum of neuro‐ psichiatric diseases SAN RAFFAELE Milano RF‐2011‐ 02347456 ROLE OF THE NEUROTROPHIN BDNF AND ITS INTERACTION WITH ENVIRONMENTAL FACTORS IN THE REGULATION OF THROMBOSIS MONZINO RF‐2011‐ 02349645 Early diagnosis, tumor response to neoadjuvant treatments and diagnosis of tumor recurrence using new andnon‐ invasive biomarkers in colon and rectal cancer I. O. V. Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 2 ‐ Translational Clinical Oncology 11 Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 11 Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 11 Immunology The new biotechnologies 11 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 11 Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 11 Oncology 2 ‐ Translational Clinical Oncology 11 Clinical Clinical Pagina 37 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347166 PREVENTION OF MOTHER‐TO‐CHILD TRANSMISSION OF HIV: SAFETY, EFFICACY AND ACCEPTABILITY OF THE ADMINISTRATION OF TENOFOVIR, LAMIVUDINE AND EFAVIRENZ WITHIN A LIFELONG TREATMENT STRATEGY FOR ALL PREGNANT WOMEN WITH HIV ISS RF‐2011‐ 02350082 The "TRIPL‐A Study". A TRIal to promote PhysicaL Activity among patients in the young‐old age affected by Type 2 diabetes I.N.R.C.A. RF‐2011‐ 02349303 Impact of deep Transcranic Magnetic Stimulation (TMS) on satiety and weight control SAN DONATO RF‐2011‐ 02350814 Molecular and cellular mechanisms of vestibular compensation Piemonte RF‐2011‐ 02349953 PROMOTING MOTOR RE‐LEARNING IN PATIENTS WITH STROKE BY ENHANCING NON INVASIVELY ASSOCIATED CEREBELLAR‐CORTICAL PLASTICITY. RF‐2011‐ 02350243 RF‐2011‐ 02346773 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. AIDS and Related Research Infection and immunity 11,25 Clinical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease 11,25 Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 11,25 Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 11,5 SANTA LUCIA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 11,5 Targeting the CCR2 and CCL2 system to modulate macrophage recruitment and polarization in amyotropic lateral sclerosis HUMANITAS Biomedical Immunology Infection and immunity 11,5 Development of a therapeutic approach against HIV/AIDS combining the delivery of single‐chain Fv antibodies and transcription activator like effector protein. ISS Biomedical AIDS and Related Research The new biotechnologies 11,5 Pagina 38 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351164 Hypothyroidism and Endometrial function during Blastocyst Implantation. Lazio RF‐2011‐ 02351812 APPLICATIONS OF ULTRASTRUCTURAL CELL ANALYSIS IN THE FIELD OF REPRODUCTIVE TECHNOLOGIES BURLO GAROFALO RF‐2011‐ 02351688 Development of a biotech system for natural compound production, by plant in vitro tissue culture, for the prevention and treatment of human dismetabolic diseases. RF‐2011‐ 02348728 Sonic hedgehog signaling and cholesterol dishomeostasis at the primary cilium in Niemann Pick C disease: implications for therapy RF‐2011‐ 02349114 Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 11,5 Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies 11,5 ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 11,5 Friuli‐Venezia Giulia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 11,5 Dissecting the interplay between ERK and SAN RAFFAELE Milano JNK signalling in the brain. From basic mechanisms to new therapeutic approaches against neurodenegerative disorders. Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 11,5 RF‐2011‐ 02349413 Development of nanostructured biomimetic nerve scaffolds Piemonte Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 11,5 RF‐2011‐ 02348876 Novel mechanisms mediated by nicotinic acetylcholine receptors, and interactions with nuclear PPARalpha, in the neuropathogenesis of epilepsy: preclinical and translational studies Sardegna Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 11,5 Pagina 39 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02351659 Assessing the exposure of children and other vulnerable population groups to priority dietary contaminants ISS Biomedical Veterinary Food safety and animal welfare 11,5 RF‐2011‐ 02350134 Discovery of Tat mimicking compounds to fight HIV latency ISS Biomedical AIDS and Related Research Infection and immunity 11,5 RF‐2011‐ 02349133 EMERGING NOROVIRUS MUTANT AND ISS RECOMBINANT STRAINS: A MOLECULAR EPIDEMIOLOGICAL INVESTIGATION ON SEWER SYSTEMS AND HOSPITALIZED PATIENTS Biomedical Infectious Diseases and Microbiology Infection and immunity 11,5 RF‐2011‐ 02350520 Recurrent herpes virus infections as risk factor for Alzheimer`s disease SAN RAFFAELE Pisana‐ Roma Biomedical Infectious Diseases and Microbiology Neurological diseases 11,5 RF‐2011‐ 02351964 Characterization and rescue of impaired dopaminergic signaling in primary torsion dystonia SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 11,5 RF‐2011‐ 02348296 Tuberculosis in HIV/AIDS patients: genetic diversity and drug‐resistance of clinical isolates of Mycobacterium tuberculosis Toscana Biomedical AIDS and Related Research Infection and immunity 11,5 RF‐2011‐ 02350445 Autoreactive T cell expansion under the influence of interleukin‐7 in patients with type I diabetes during beta cell replacemement therapy SAN RAFFAELE Milano Biomedical Immunology Infection and immunity 11,5 RF‐2011‐ 02350491 Role of the miR‐132~212 cluster in B‐cell receptor signaling in chronic lymphocytic leukemia: novel targets with therapeutic potential C.R.O. AVIANO Biomedical Oncology 1 ‐ Basic Translational Infection and immunity 11,5 AREA STRATEGICA SCORE. Pagina 40 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347099 The MINA PROJECT. Mirror Neurons In Alcoholics: can Mirror Neuron System help us to understand and treat Alcohol Addiction? Emilia‐Romagna Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 11,5 RF‐2011‐ 02352119 In vivo generation of Tregs with differential homing capabilities for dissociating the antitumor effects of clinical hematopoietic stem cell transplantation from graft‐versus‐ host disease SAN RAFFAELE Milano Biomedical Immunology Oncology 11,5 RF‐2011‐ 02348397 Astrocyte TRK on demyelination SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 11,5 RF‐2011‐ 02348103 Genetic and antigenic diversity and pathogenicity of viruses associated with enteritis Emilia‐Romagna Biomedical Infectious Diseases and Microbiology Infection and immunity 11,5 RF‐2011‐ 02352636 The availability of "old" and "new" drug Veneto eluting stents in routine clinical practice: influence on the treatment choice among medical therapy vs. percutaneous coronary interventions vs. coronary by‐pass surgery and on 4‐year clinical outcome in patients w Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 11,5 RF‐2011‐ 02350984 Intraventricular injection of Peripheral Blood Stem Cells during coronary artery bypass grafting in patients with heart failure induced by previous myocardial infarction. Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 11,5 Campania Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 41 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351933 SMART FOOD AND LIFESTYLE INTERVENTIONS FOR HEALTHY BRAIN AGING.Developing a comprehensive protocol to assess the preventive effects of lifestyle interventions on food habits, physical and cognitive activity and social and cultural participation on cognit CARLO BESTA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 11,5 RF‐2011‐ 02347955 A multicenter prospective study on inflammatory/infectious CNS diseases in different immunological settings: a multidisciplinary approach using an online data base MONDINO Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 11,5 RF‐2011‐ 02347690 Pyrimethamine derivatives: a new generation of antifolate drugs for treatment of metastatic melanoma. A prepreclinicalstudy. ISS Biomedical Oncology 1 ‐ Basic Translational Oncology 11,5 RF‐2011‐ 02347254 Targeting leukemia cells by CD1c‐restricted autoreactive T cell response SAN RAFFAELE Milano Biomedical Immunology Oncology 11,5 RF‐2011‐ 02347403 The tumor cell spheroid as a key factor in C.R.O. AVIANO the drug resistance and dissemination of high grade ovarian serous carcinoma (sEOC) Biomedical Oncology 1 ‐ Basic Translational Oncology 11,5 RF‐2011‐ 02347280 Morphofunctional visual pathways evaluation in multiple sclerosis: possible identification of neurodegenerative bio‐ markers Integrative, Functional, and Cognitive Neuroscience Neurological diseases 11,5 BIETTI Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 42 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02350517 Inflammatory mechanisms underlying cortico‐hippocampal hyperexcitability in Alzheimer's disease: from in vitro and in vivo murine models to patient SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 11,5 RF‐2011‐ 02351069 CDCP1 as a Therapeutic Target in Triple‐ Negative Breast Cancer IST.TUMORI MILANO Biomedical Oncology 2 ‐ Translational Clinical Oncology 11,5 RF‐2011‐ 02350309 Improving Prognostic Accuracy in Severe Traumatic Brain Injury with Diffusion Tensor Imaging MRI Combined with Cerebral Microdialysis Measurements of Axonal Proteins MAGGIORE Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 11,5 RF‐2011‐ 02348920 Analysis of the role of different isoforms of thymic stromal lymphopoietin and the microbiota in T cell activation in inflammatory conditions of the gut I.E.O. Immunology Infection and immunity 11,75 RF‐2011‐ 02351200 Colonization and infection by extensively‐ drug resistant carbapenemase‐producing Enterobacteriaceae: towards a better understanding of the emergence and dynamics of colonization within the complex ecosystem of the human gut microbiome, of relationships be Toscana Biomedical Infectious Diseases and Microbiology Infection and immunity 11,75 RF‐2011‐ 02350164 Food nanomaterials exposure assessment ISS Biomedical Veterinary Food safety and animal welfare 11,75 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 43 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347709 Identification of Biomarkers for Non Melanoma Skin Cancers in a Multicenter Cohort of Kidney Transplant Recipients: Evaluation of Ethiopatogenetic Role and Clinical Implications. Piemonte RF‐2011‐ 02347956 Role of ATM kinase in cerebellum development, homeostasis and function: implications for Ataxia Telangiectasia and other cerebellar disorders SANTA LUCIA RF‐2011‐ 02352294 CIRCULATING CELL‐FREE BIOMARKERS Toscana IN THE DIAGNOSIS AND FOLLOW UP OF DIFFERENTIATED THYROID CANCER RF‐2011‐ 02349478 A multiparametric approach based on clinical, biochemical, genetic and neuroimaging data to predict cognitive impairment in Parkinson's disease CASA SOLLIEVO SOFFERENZA RF‐2011‐ 02348600 Role of Neutrophil activation and NET formation in venous thromboembolic disease Veneto RF‐2011‐ 02348213 Neurophysiological approach to evaluate cerebro‐cerebellar interactions. Characterization of a cerebellar connectivity EEG index. SANTA LUCIA RF‐2011‐ 02350732 ANTI‐HPV CANCER THERAPY BY ENGINEERED EXOSOMES INCORPORATING siRNAs AND miRNAs ISS Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 2 ‐ Translational Clinical Oncology Molecular, Cellular, and Developmental Neuroscience Neurological diseases 12 Oncology 2 ‐ Translational Clinical Oncology 12 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12 Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 12 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 12 Biomedical Bioengineering Sciences and Technologies Oncology 12 Biomedical Clinical 11,75 Pagina 44 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347106 Development of high throughput, integrated and cost‐effective molecular diagnostic tests for the detection of genetic and epigenetic defects involved in human disease MAGGIORE RF‐2011‐ 02347560 Discovering metabolomic signatures associated with specific gene mutations in melanoma and their role in tumor radiosensitivity and immunogenicity ISS RF‐2011‐ 02347557 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Genes, Genomes and Genetics The new biotechnologies 12 Biomedical Oncology 1 ‐ Basic Translational Oncology 12 Role of chronic inflammation in the Emilia‐Romagna pathogenesis of Philadelphia‐negative myeloproliferative neoplasms (MPNs): an in vitro and in vivo biomolecular and functional analysis of the stem/progenitor and megakaryocytic cell compartments Biomedical Cell Biology Oncology 12 RF‐2011‐ 02351833 Cardiac natriuretic peptides, human adipocytes, hypertension and dysmetabolism: in‐depth in vitro analysis and clinical study in elderly patients with type 2 diabetes mellitus or chronic heart failure I.N.R.C.A. Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 12 RF‐2011‐ 02352136 Unravelling the interplay between Helicobacter pylori and the host. Biomarkers and diagnostic tools for evaluation of H. pylori‐infected patients. Toscana Biomedical Infectious Diseases and Microbiology Infection and immunity 12 RF‐2011‐ 02350888 Immunomodulation by mesenchymal stem cells as a potential therapeutic strategy for endometriosis. SAN RAFFAELE Milano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies 12 Pagina 45 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347736 CLINICAL AND MOLECULAR STUDIES OF NEXT‐GENERATION IN HEREDITARY SPASTIC PARAPLEGIAS STELLA MARIS RF‐2011‐ 02351475 Targeting streptococcal infections in the management of patients with psoriasis Toscana RF‐2011‐ 02347738 Transcritpional regulation of skeletal SANTA LUCIA muscle muscle maturation and degeneration: new potential targets for therapies against muscle wasting caused by neurogenic disorders and aging. RF‐2011‐ 02350542 Targeting late recurrence after adjuvant treatment for early breast cancer I.E.O. RF‐2011‐ 02349367 White Blood Cells expression profiles as a tool for predicting Metformin Efficacyin Patients with Type 2 Diabetes CASA SOLLIEVO SOFFERENZA RF‐2011‐ 02349439 Molecular imaging and genome wide analysis: an integrated approach to identify early diagnostic biomarkers. REGINA ELENA RF‐2011‐ 02347694 Therapeutic correction of mis‐spliced RNA transcripts and of protein conformational defects in Lysosomal Storage Disorders Toscana RF‐2011‐ 02349170 EFFECTS OF ADALIMUMAB ON PATIENT SERUM CAPACITY TO LOAD AND DISCHARGE MACHROPHAGES WITH CHOLESTEROL Lombardia Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Brain Disorders and Clinical Neuroscience Neurological diseases 12 Clinical Musculoskeletal, Oral and Skin Sciences Infection and immunity 12 Biomedical Musculoskeletal, Oral and Skin Sciences Neurological diseases 12 Oncology 2 ‐ Translational Clinical Oncology 12 Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 12 Biomedical Oncology 2 ‐ Translational Clinical Oncology 12 Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 12 Immunology Infection and immunity 12 Clinical Clinical Biomedical Pagina 46 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349223 ADOPTIVE IMMUNOTHERAPY FOR METASTATIC COLORECTAL CANCER PATIENTS Lombardia RF‐2011‐ 02352236 Identifying low‐value health care interventions for patients with neurodegenerative diseases of the Central Nervous System and Stroke to support disinvestment decisions Emilia‐Romagna Clinical RF‐2011‐ 02346810 Study of the mechanisms responsible for the increased cancer risk and reduced tumour sensitivity in obese and diabetic type 2 people: role of the interleukin 6 Emilia‐Romagna RF‐2011‐ 02347168 NSD1 PHD fingers as potential targets for Acute Myeloid Leukemia SAN RAFFAELE Milano RF‐2011‐ 02349395 Role of IP‐10 and its truncated form in the pathogenesis of tuberculosis SPALLANZANI RF‐2011‐ 02347086 Characterization of HIV‐related Emilia‐Romagna mechanisms involved in the development of Burkitt's lymphoma RF‐2011‐ 02347227 BIOLOGICAL APPROACH TO DECONTAMINATION OF BIVALVE MOLLUSCS FROM V.PARAHAEMOLYTICUS AND SALMONELLA BY MARINE BDELLOVIBRIO‐AND‐LIKE ORGANISMS (BALOs). IZS Umbria e delle Marche Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 2 ‐ Translational Clinical Oncology 12 Healthcare Delivery and Methodologies Neurological diseases 12 Biomedical Oncology 1 ‐ Basic Translational Oncology 12 Biomedical Biological Chemistry and Macromolecular Biophysics Oncology 12 Infectious Diseases and Microbiology Infection and immunity 12 Biomedical AIDS and Related Research Infection and immunity 12 Biomedical Veterinary Food safety and animal welfare 12 Clinical Pagina 47 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348800 Unravelling the genetics of Autosomal Dominant Diabetes Mellitus of the Adulthood CASA SOLLIEVO SOFFERENZA RF‐2011‐ 02350666 Can mental training based on motor imagery speed up the rehabilitation of walking? Efficacy of a controlled procedure and neurofunctional bases of recovery in patients with total knee arthroplasty RF‐2011‐ 02347475 DNA vaccines coding for chimeric human/rat HER‐2 as innovative immunotherapeutic tools for the treatment of HER‐2+ cancer patients RF‐2011‐ 02348878 Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 12 GALEAZZI Clinical Biobehavioral and Behavioral Processes Neurological diseases 12 Piemonte Biomedical Oncology 2 ‐ Translational Clinical Oncology 12 A FoxO1 metabolomics signature to identify Lazio patients at risk for major cardiovascular events: studies in human subjects with diabetes and atherosclerosis Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 12 RF‐2011‐ 02348873 Overcoming Anti‐Angiogenic Therapy Resistance: Investigation of MICAL2 as a Predictive Marker and Molecular Target in Cancer Therapy Toscana Biomedical Oncology 2 ‐ Translational Clinical Oncology 12 RF‐2011‐ 02349772 Functional topography of the spinal motor output after spinal cord injury SANTA LUCIA Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 12 RF‐2011‐ 02350903 Medication overuse headache as a form of dependence Emilia‐Romagna Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12 Pagina 48 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02351145 A novel in‐vivo diagnostic test for Creutzfeldt‐Jakob disease (CJD) patients by nasal brushing ISS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12 RF‐2011‐ 02348334 Role of exosomes in pericardial fluid‐ mediated cardiac regeneration. SAN RAFFAELE Pisana‐ Roma Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 12 RF‐2011‐ 02347420 Monitoring disease progression and phenotypic heterogeneity in hereditary ataxias: clinical, cognitive, neuroimaging, and neurophysiological study to identify early markers of cerebellar dysfunction in patients and presymptomatic carriers CARLO BESTA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 12 RF‐2011‐ 02351306 Role of autophagy impairment in the progression from steatohepatitis to hepatocarcinoma in Hepatitis C patients. SPALLANZANI Biomedical Infectious Diseases and Microbiology Infection and immunity 12 RF‐2011‐ 02350193 Assessment of strategies for identifying undiagnosed type 2 diabetes mellitus Veneto Clinical Population Sciences and Epidemiology Metabolism disorders and cardiovascular disease 12 RF‐2011‐ 02350374 Effects of action observation therapy on rehabilitation of motor deficits of the dominant right upper limb in patients with MS: a study with structural and functional MRI. SAN RAFFAELE Milano Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 12 RF‐2011‐ 02350220 Roles of mesopontine‐subthalamic nucleus projections in the control of basal ganglia functions and in Parkinson disease Lazio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12 AREA STRATEGICA SCORE. Pagina 49 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02350369 Biomechanical Characterization of carotid Plaque by Innovative Ultrasound in Stroke (BioCaPS) Toscana Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering Neurological diseases 12 RF‐2011‐ 02350898 Cardiotrophin‐1 as a biomarker of left ventricular dysfunction in Hypertensive Heart Disease AUXOLOGICO Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 12 RF‐2011‐ 02351930 Use of RNA aptamers as a novel tool for I. O. V. targeting Tumor Educated Myeloid Cells to control metastatic disease Biomedical Oncology 1 ‐ Basic Translational Oncology 12 RF‐2011‐ 02348944 Identification and validation of novel biomarkers for Multiple Sclerosis and Alzheimer's Disease SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12 RF‐2011‐ 02351021 Modeling and taming the genotoxicity of viral vector integration SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics The new biotechnologies 12 RF‐2011‐ 02346914 Phase 1/2 study of valproic acid and short‐ course radiotherapy plus capecitabine as preoperative treatment in low‐moderate risk rectal cancer PASCALE Clinical Oncology 2 ‐ Translational Clinical Oncology 12 RF‐2011‐ 02348240 Reperfusion injury after cerebral ischemia: an "in vivo" study using neuro‐imaging markers Toscana Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 12 RF‐2011‐ 02348258 Toward a mitochondrial‐imbalance readjustment therapeutic approach to counteract remote degeneration after focal acute brain damage SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12 AREA STRATEGICA SCORE. Pagina 50 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02346993 Interference evaluation of cancer microenvironment in the tumor‐specific immune response of pancreatic cancer patients Toscana Biomedical Oncology 1 ‐ Basic Translational Oncology 12 RF‐2011‐ 02352373 NOVEL AND SELECTIVE ANTI‐TUMOR STRATEGIES FOR THE TREATMENT OF GLIOMA IDI Biomedical Oncology 1 ‐ Basic Translational Oncology 12 RF‐2011‐ 02346938 ASIC1: a Therapeutic Target for new neuroprotective pharmacological approaches for multiple sclerosis SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12 RF‐2011‐ 02352096 Alcohol intake and abuse in workplaces: development of an integrated protocol based on screening questionnaire and new methods for biological sampling and analysis. Application in healthcare workers according to Italian legislation Emilia‐Romagna Clinical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 12,25 RF‐2011‐ 02349311 Development of different technologies and alternative in vivo assays to evaluate the safety of medical devices. IZS Lombardia e dell'Emilia Biomedical Veterinary Food safety and animal welfare 12,25 RF‐2011‐ 02350948 Animal and human monoamine oxidases inhibition as a new strategy against anthracyclines‐induced mitochondrial cardiotoxicity in cancer therapy I.E.O. Clinical Oncology 2 ‐ Translational Clinical Oncology 12,5 RF‐2011‐ 02347554 Cardiovascular risk and genetic hypercholesterolemias: improving risk assessment to optimize treatment. Sicilia Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 12,5 AREA STRATEGICA SCORE. Pagina 51 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349172 Genetic and epigenetic biomarkers in myasthenia gravis Toscana RF‐2011‐ 02348483 Predicting post‐surgery complications in patients undergoing coronary artery bypass graft or major spine surgery through the assessment of perioperative cardiovascular control indexes RF‐2011‐ 02347483 Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Genes, Genomes and Genetics Neurological diseases 12,5 GALEAZZI Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering Metabolism disorders and cardiovascular disease 12,5 Standardization of cord blood CD34+ cell count in a European multicenter trial. Impact on haematopoetic stem cell transplantation for haematological malignancies. Lombardia Biomedical Vascular and Hematology Oncology 12,5 RF‐2011‐ 02347481 Epigenetic therapy for the treatment of Parkinson's disease and improvement of exercise‐based rehabilitation S.CAMILLO Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12,5 RF‐2011‐ 02349924 The use of classical conditioning with a telemedicine approach for anomia rehabilitation in chronic aphasia: a clinical outcome research SANTA LUCIA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 12,5 RF‐2011‐ 02349734 Effects of mandibular stretching on arterial blood pressure in normal volunteers and in patients with arterial hypertension: a single blinded randomized study Toscana Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 12,5 Pagina 52 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347687 ASSESSMENT OF NEOPLASTIC CONTAMINATION IN CRYOPRESERVED OVARIAN TISSUE OF PATIENTS AFFECTED BY SARCOMAS AND HEMATOLOGICAL MALIGNANT DISEASES: SAFETY OF TISSUE AUTOTRANSPLANTATION Emilia‐Romagna Clinical Oncology 2 ‐ Translational Clinical Oncology 12,5 RF‐2011‐ 02349418 Gut Bacteria (microbiOta) in HepAtic EncephaLopathy and Possible Utility of its Modulation (the GOAL study) DE BELLIS Clinical Infectious Diseases and Microbiology Infection and immunity 12,5 RF‐2011‐ 02352570 Hyperthermic intra‐peritoneal Umbria chemotherapy (HIPEC) in Ovarian cancer recurrence: a Randomized multicentric trial on Survival Evaluation[HORSE trial] Clinical Oncology 2 ‐ Translational Clinical Oncology 12,5 RF‐2011‐ 02351276 IDENTIFICATION OF AN AUTOIMMUNE AETIOLOGY, AS DETERMINED BY SERUM AUTOANTIBODIES TO LGI1 AND OTHER CELL‐SURFACE MEMBRANE PROTEINS, IN TEMPORAL LOBE EPILEPSIES OF OTHERWISE UNKNOWN AETIOLOGY Ist.Sci. Neurologiche Bologna Brain Disorders and Clinical Neuroscience Neurological diseases 12,5 RF‐2011‐ 02349589 INHIBITION OF DRUGGABLE GENE ABERRATIONS IN ER‐POSITIVE OR TRIPLE NEGATIVE OPERABLE BREAST CANCER. A WINDOW OF OPPORTUNITY TRIAL Emilia‐Romagna Oncology 2 ‐ Translational Clinical Oncology 12,5 Biomedical Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 53 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352283 The role of epigenetic in thyroid cancer REGINA ELENA progression and resistance to radio‐iodine therapy. Focus on multiple promoter methylation of thyroid‐specific genes (TSH‐ R, NIS, SLC26A4, SLC5A8), and non thyroid specific BRAF‐associated genes (TIMP3, DAPK, RAR‐B RF‐2011‐ 02352589 Effects pf pre‐surgical cognitive rehbilitation on memory outcome after temporal lobe epilepsy surgery CARLO BESTA RF‐2011‐ 02347578 Novel high‐troughoutput approaches for minimal residual disease (MRD) detection in mantle cell lymphoma (MCL) RF‐2011‐ 02348436 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 1 ‐ Basic Translational Oncology 12,5 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 12,5 Provincia autonoma Bolzano Clinical Oncology 2 ‐ Translational Clinical Oncology 12,5 The role of breath fingerprints in differential diagnosis and treatment response of lower respiratory tract infections of bacterial origin Sicilia Clinical Bioengineering Sciences and Technologies The new biotechnologies 12,5 RF‐2011‐ 02351923 miRNAs in lung tumorigenesis: expression signatures of serum circulating miRNAs in lung cancer patients and their functional analysis SDN Biomedical Oncology 2 ‐ Translational Clinical Oncology 12,5 RF‐2011‐ 02349331 Lung cancer cell cultures from mediastinal node metastasis to develop target therapies. Lazio Clinical Oncology 1 ‐ Basic Translational Oncology 12,5 RF‐2011‐ 02348175 Molecular mechanisms of cystic fibrosis inflammation: Identification of novel potential biomarkers and therapeutic targets. Abruzzo Biomedical Cardiovascular and Respiratory Sciences Infection and immunity 12,5 Pagina 54 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349179 Prognostic and Predictive microRNA Biomarkers in Sarcoma C.R.O. AVIANO Biomedical Oncology 2 ‐ Translational Clinical Oncology 12,5 RF‐2011‐ 02348219 Soluble urokinase plasminogen activator receptor sustains immune activation in HIV+ individuals. SAN RAFFAELE Milano Biomedical AIDS and Related Research Infection and immunity 12,5 RF‐2011‐ 02348273 Evaluation of the effect of testosterone replacement therapy (TRT) on prostatic gland in hypogonadal patients affected by benign prostatic hyperplasia (BPH) and metabolic syndrome (MetS) Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 12,5 RF‐2011‐ 02350510 NEXT GENERATION SEQUENCING OF GLIOBLASTOMA IMMUNOEDITING AFTER DENDRITIC CELL IMMUNOTHERAPY CARLO BESTA Biomedical Oncology 2 ‐ Translational Clinical The new biotechnologies 12,5 RF‐2011‐ 02348281 Synthesis and characterization of peptide‐ peptidomimetics with antagonistic activity against thrombopoietin (TPO) for the treatment of severe sepsis and septic shock: pre‐clinical studies. Piemonte Biomedical Infectious Diseases and Microbiology The new biotechnologies 12,5 RF‐2011‐ 02350131 PINOCCHIO: computer‐aided Planning and monItoriNg biological bOne reConstructions in CHIldren Oncology. RIZZOLI Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering Oncology 12,5 RF‐2011‐ 02351729 Psychological implications in robotic rehabilitation for sub‐acute stroke patients Veneto Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 12,5 RF‐2011‐ 02351969 Mechanisms of fluoropyrimidine toxicities in the perspective of personalized medicine. ARCISPEDALE‐Reggio Emilia Clinical Oncology 2 ‐ Translational Clinical Oncology 12,5 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 55 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02348875 A multidisciplinary approach to Early Onset ISS Dementia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12,5 RF‐2011‐ 02351766 AVIAN BOTULISM IN LAZIO REGION: DEVELOPMENT OF A FIELD MODEL TO UNDERSTAND THE PATHOGENESIS OF AN EMEGERGING DISEASE IZS Lazio e della Toscana Biomedical Veterinary Food safety and animal welfare 12,5 RF‐2011‐ 02351126 The Impact of Prenatal Immune Deregulations on Synaptopathies: the case of maternal cytomegalovirus infection. HUMANITAS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12,5 RF‐2011‐ 02347284 unraveling the pathogenesis of autoinflammatory syndromes: from improved molecular diagnosis to the identification of novel therapeutic targets BURLO GAROFALO Immunology Infection and immunity 12,5 RF‐2011‐ 02350140 Endothelial cell alterations in metabolic syndrome, obesity and diabetes: Gender, molecular and cellular mechanisms in prevention of cardiovascular risk. MULTIMEDICA Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 12,5 RF‐2011‐ 02349169 The emerging role of microRNAs in autism spectrum disorders OASI MARIA S.S. Biomedical Genes, Genomes and Genetics Neurological diseases 12,5 RF‐2011‐ 02349149 Therapeutic drug monitoring protocols for dose personalization of antibacterial agents administered to patients with severeGram‐ positive infections Toscana Healthcare Delivery and Methodologies Infection and immunity 12,5 Clinical Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 56 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352247 A COMBINATION THERAPY Emilia‐Romagna COMPRISING A 'MEGADOSE' OF T CELL DEPLETED HEMATOPOIETIC STEM CELL TRANSPLANT, HIGH DOSE POST‐ TRANSPLANT CYCLOPHOPHAMIDE AND A REDUCED INTENSITY CONDITIONING FOR A STABLE AND LONG TERM ENGRAFTMENT RF‐2011‐ 02349996 Framework for Genomic Analysis and Molecular Epidemiology in foodborne bacterial pathogens (acr.: GAME‐food) IZS Abruzzo e del Molise RF‐2011‐ 02348533 Calcium‐sensing receptor as a predictive marker in hypertensive patients SAN RAFFAELE Milano RF‐2011‐ 02351076 Non‐coding RNAs as prognostic markers for treatment personalization of cutaneous melanoma Veneto RF‐2011‐ 02347858 OVARIAN CANCER STEM CELLS: PHENOTYPIC, GENOTYPIC AND METABOLIC CHARACTERIZATION OF A SUITABLE TARGET FOR LOCO‐ REGIONAL THERAPIES RF‐2011‐ 02350531 RF‐2011‐ 02350363 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Immunology Infection and immunity 12,5 Veterinary Food safety and animal welfare 12,5 Vascular and Hematology Metabolism disorders and cardiovascular disease 12,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 12,5 I. O. V. Biomedical Oncology 1 ‐ Basic Translational Oncology 12,5 Circulating Microvesicles: a Novel Biological Marker in Crohn's Disease Lazio Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 12,5 Manipulation of the extra‐uterine environment through infant massage in preterm infants: effects on brain structure and function (a RCT) STELLA MARIS Brain Disorders and Clinical Neuroscience Neurological diseases 12,5 Biomedical Clinical Clinical Pagina 57 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347199 Molecular understanding of E3 ligases involved in signaling and cancer I.E.O. Biomedical Biological Chemistry and Macromolecular Biophysics Oncology 12,5 RF‐2011‐ 02351078 The use of nanoparticles in food technology: silver nanoparticles behaviour in complex food matrices and antibacterial resistance implications IZS Venezie Biomedical Veterinary Food safety and animal welfare 12,5 RF‐2011‐ 02347563 ENGINEERED EXOSOMES FOR A NEW GENERATION OF ANTI‐HCV VACCINES ISS Biomedical Immunology Infection and immunity 12,75 RF‐2011‐ 02349823 A susceptibility marker for Amyotrophic Lateral Sclerosis: genetic and functional analysis of polymorphisms of P2RX7 gene coding for purinergic P2X7 receptor for extracellular ATP, in a cohort of ALS patients. SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12,75 RF‐2011‐ 02351902 Alloimmunity and infection: insight into pathogen‐driven alloreactivity to develop preventive strategies for late kidney graft failure GASLINI Digestive, Kidney and Urological Systems Infection and immunity 12,75 RF‐2011‐ 02350279 Electro‐clinical features, brain networks, and gene expression in Ring20 epilepsy syndrome Lombardia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12,75 RF‐2011‐ 02350593 Identification of inducers of skin wound repair for the treatment of non‐healing ulcers in diabetic patients IDI Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 12,75 RF‐2011‐ 02350859 Microglia‐based device as a biosensor for Amyotrophic Lateral Sclerosis pathogenesis SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 12,75 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 58 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02351046 The purinergic P2X7 receptor on human cardiac fibroblast: a new therapeutic target to control cardiac remodelling in chronic heart failure? Toscana Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 13 RF‐2011‐ 02349837 Role of brain/cognitive reserves on neurodegenerative pathology SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13 RF‐2011‐ 02351132 Prevention of antibody‐mediated chronic Veneto allograft injury in a prospective longitudinal study in renal transplant patients Biomedical Immunology The new biotechnologies 13 RF‐2011‐ 02351061 Pediatric Cardiomyopathy: new genetic diagnostic approach by next generation sequencing (NGS) and its relation to therapeutic efficacy SDN Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 13 RF‐2011‐ 02349912 A preclinical translational study for pharmacological inhibition of G protein Receptor Kinase 2 for the treatment of cardiac dysfunction: A metabolic approach. Campania Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 13 RF‐2011‐ 02350078 GALACTOSYLATED PRODRUG OF KETOROLAC WITH BETTER PHARMACOKINETIC PROPERTIES AND REDUCED TOXICITY Campania Clinical Interdisciplinary Molecular Sciences and Training The new biotechnologies 13 RF‐2011‐ 02351009 A multidisciplinary investigation for the improvement of aortic endografting: from biomedical engineering concepts to clinical implementation. SAN DONATO Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering Metabolism disorders and cardiovascular disease 13 AREA STRATEGICA SCORE. Pagina 59 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02350700 The Lectin pathway as a therapeutic target in stroke Lazio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13 RF‐2011‐ 02349897 Viral microRNAs: a secret weapon for host gene expression alteration in B‐cell lymphomas Toscana Biomedical Oncology 1 ‐ Basic Translational Oncology 13 RF‐2011‐ 02348224 Standard Operating Procedures for MR‐ based Cortical Thickness Estimation FATEBENEFRATELLI Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13 RF‐2011‐ 02351552 A genome‐based and functional approach to improve the diagnosis and define the molecular basis of syndromic and non‐ syndromic intellectual disability Piemonte Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13 RF‐2011‐ 02351570 Role of intestinal microbiota in the Emilia‐Romagna occurrence of systemic septic complications in patients with post‐traumatic spinal cord and cerebral injury. Biomedical Digestive, Kidney and Urological Systems Infection and immunity 13 RF‐2011‐ 02351613 Aphasia. Theory for Therapy. S.CAMILLO Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 13 RF‐2011‐ 02349091 Serum myostatin and type 2 diabetes: correlation with degree of metabolic control SDN Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 13 RF‐2011‐ 02351723 Advanced and innovative procedures for NEUROLESI diagnosis and management of patients affected by Limb Girdle Muscle Dystrophies (LMGD) and other related myopathies. Musculoskeletal, Oral and Skin Sciences Neurological diseases 13 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 60 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348858 Effectiveness of a Communication Skills Lombardia Training program for oncology clinicians on patient Health‐Related Quality of Life: a stepped‐wedge, cluster randomized controlled trial RF‐2011‐ 02348699 A packaging RNA nanotherapeutic approach to arrest nigrostriatal dopaminergic neuronal cell death in experimental Parkinson's disease RF‐2011‐ 02348681 Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Clinical Risk, Prevention and Health Behavior Oncology 13 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13 Autologous transplantation of SPIO‐labeled Liguria bone marrow stem cells in Critical Limb Ischemia (CLI): a preclinical study. Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 13 RF‐2011‐ 02348661 Cotransplantation of pancreatic islets and engineered, third‐party, human umbilical cord mesenchymal stem cells as a novel approach to improve graft survival and immune‐tolerance in type 1 diabetes patients Toscana Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 13 RF‐2011‐ 02348649 Peptides from lactoferrin as new therapeutic agents against Influenza virus infection ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 13 RF‐2011‐ 02350839 Telemedicine network for diagnosis and care of congenital heart malformations Toscana Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 13 RF‐2011‐ 02348532 Dipeptidyl peptidase IV inhibitors and the complex P2X7 receptor‐inflammasome: in vitro and in vivo studies. Toscana Biomedical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease 13 OASI MARIA S.S. Pagina 61 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02351549 Acute coronary syndrome and long term outcome: the role of nitric oxide synthesis in red blood cells MONZINO Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 13 RF‐2011‐ 02348318 Analysis of KIR genotype/phenotype and HLA supratype on NK and CD8+ T cell subpopulations in elite controller, long term non‐progressor and HIV‐1‐cronically infected subjects GASLINI Biomedical AIDS and Related Research Infection and immunity 13 RF‐2011‐ 02348439 PREVENTION AND DIAGNOSIS OF FETAL ALCOHOL SYNDROME (FAS) AND FETAL ALCOHOL SPECTRUM DISORDER(FASD) Lazio Brain Disorders and Clinical Neuroscience The new biotechnologies 13 RF‐2011‐ 02348223 Combinatorial treatments to target cancer stem cells and elicit DNA damage in triple negative breast cancer Toscana Oncology 1 ‐ Basic Translational Oncology 13 RF‐2011‐ 02348141 Cortical myoclonus: implementation of innovative quantitative diagnostic tests and a new therapeutic strategy based on repetitive transcranial magnetic stimulation. CARLO BESTA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 13 RF‐2011‐ 02352176 A biopathological investigation of Nodular Lymphocyte Predominant Hodgkin Lymphoma in pediatric and adolescents patients. C.R.O. AVIANO Biomedical Oncology 2 ‐ Translational Clinical Oncology 13 RF‐2011‐ 02347764 Interferome: renaissance of the innate immune system in understanding dysregulated genes and networks in multiple sclerosis. ISS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13 Clinical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 62 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347584 Metal on metal hip prosthesis: Cobalt‐ induced neurotoxicity RIZZOLI RF‐2011‐ 02352325 Development and validation of a multiplex real‐time PCR assay for the identification and discrimination of virulent Listeria monocytogenes strains in food IZS Umbria e delle Marche RF‐2011‐ 02352418 Characterization of the interactions occurring inside the EGFR axis macromolecular complexes expressed in pancreatic ductal adenocarcinoma Lazio RF‐2011‐ 02352423 Advanced ovarian cancer as an immunologic, endocrine and metabolic disorder. Translational research for the development of a targeted approach of advanced ovarian cancer‐related symptoms. Sardegna RF‐2011‐ 02352456 Early use of extracorporeal membrane Lombardia oxygenation in Cardiogenic Shock (ECMICS) RF‐2011‐ 02347258 Assessment of transplant benefit of downstaging strategies in patients with hepatocellular carcinoma exceeding Milan Criteria: a randomized study IST.TUMORI MILANO RF‐2011‐ 02347211 NOVEL TOOLS TO STUDY AND INHIBIT MALARIA GAMETOCYTE SEQUESTRATION IN HUMAN BONE MARROW ISS Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Brain Disorders and Clinical Neuroscience Neurological diseases 13 Veterinary Food safety and animal welfare 13 Clinical Oncology 2 ‐ Translational Clinical Oncology 13 Biomedical Oncology 2 ‐ Translational Clinical Oncology 13 Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 13 Clinical Oncology 2 ‐ Translational Clinical Oncology 13 Infectious Diseases and Microbiology Infection and immunity 13 Biomedical Biomedical Pagina 63 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02346965 Metastasis at the onset: to inhibit cell cannibalism in order to hinder tumor spreading ISS Biomedical Oncology 1 ‐ Basic Translational Oncology 13 RF‐2011‐ 02346855 Branched peptides as cancer theranostics Toscana Biomedical Oncology 2 ‐ Translational Clinical Oncology 13 RF‐2011‐ 02351931 Modulation of miRNA lung cancer risk biomarkers by low‐dose aspirin in former smokers Liguria Clinical Oncology 2 ‐ Translational Clinical Oncology 13 RF‐2011‐ 02349531 Therapeutic potential and safety assessment of gene‐corrected Neural Stem/Progenitor Cells (NSPC) derived from patient‐specific induced Pluripotent Stem Cells (iPSC) in murine models of Lysosomal Storage Diseases (LSD). SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics Neurological diseases 13 RF‐2011‐ 02349752 Laparoscopic sleeve gastrectomy versus conventional medical therapy in patients with newly diagnosed type 2 diabetes and Body Mass Index 30‐34.9 Kg/m2: a randomized clinical trial Umbria Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 13 RF‐2011‐ 02351523 Proof‐of‐principle investigation of NAMPT Piemonte inhibitors in cancer and inflammatory states Biomedical Oncology 2 ‐ Translational Clinical Oncology 13 RF‐2011‐ 02349661 Markers of refractoriness in Gilles de la Tourette syndrome: pharmachological therapies and deep brain stimulation. Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13 GALEAZZI Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 64 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349635 Non Alcoholic Fatty Liver Disease (NAFLD) , vitamin D and cardiometabolic risk: a proof of concept study Lombardia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 13 RF‐2011‐ 02349283 Pathophysiology of frontal cortical impairments in phenylketonuria: a translational investigation. SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13 RF‐2011‐ 02349495 Global Rare Tumor Networking and new staging/prognostic concepts in Thymic Epithelial Tumors and in Non Small Cell Lung Carcinomas metastatic to the Mediastinum: an integrated clinicopathological and molecular study REGINA ELENA Clinical Oncology 2 ‐ Translational Clinical Oncology 13 RF‐2011‐ 02348744 A combined therapeutic approach to Spino‐ Bulbar Muscle Atrophy (SBMA): from cellular models to clinical studies CARLO BESTA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13,25 RF‐2011‐ 02348459 A needs‐based approach to forecast future medical specialists' requirement for the Emilia‐Romagna Regional (ERR) NHS Emilia‐Romagna Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 13,25 RF‐2011‐ 02349801 The possible role of transforming growth factor beta1 and vitamin D in regulating disease activity and brain atrophy in patients with Multiple Sclerosis. SANTA LUCIA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 13,25 RF‐2011‐ 02347423 Dendritic cell engineering with IRF‐1 and ISS IRF‐8 for new immunotherapy interventions Oncology 2 ‐ Translational Clinical Oncology 13,25 Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 65 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02350532 Occurrence of Ostreopsis genus blooms in Tyrrhenian sea : tools to prevent human intoxication due to palytoxins contaminated seafood. ISS Biomedical Veterinary Food safety and animal welfare 13,25 RF‐2011‐ 02352345 Discovery of new biomarkers predictive of outcome in comatose patients resuscitated from cardiac arrest AOU San Martino‐IST ‐ Genova Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13,25 RF‐2011‐ 02348185 Human and swine influenza viruses: reassortment and zoonotic risks IZS Lombardia e dell'Emilia Biomedical Veterinary Food safety and animal welfare 13,5 RF‐2011‐ 02352495 Molecular, Pharmacogenomic and Metabolic factors associated with Recurrence in a Randomized Trial of adjuvant therapy with Aromatase Inhibitors PASCALE Biomedical Oncology 2 ‐ Translational Clinical Oncology 13,5 RF‐2011‐ 02352578 Detection of Oxidative Base‐Specific Lesions in the Exon 1 of the K‐RAS and Other Cancer Related Genes of Patients with Newly Diagnosed Colorectal Adenocarcinoma and Colorectal Polyps Toscana Biomedical Population Sciences and Epidemiology Oncology 13,5 RF‐2011‐ 02350449 Dissection of the effects of mesenchymal stem cells on glial cells involved in neurogenesis AOU San Martino‐IST ‐ Genova Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13,5 RF‐2011‐ 02348265 Novel approaches to understand HIV‐1 nucleotide diversity affecting viral evolution, drug‐resistance development, and related clinical implications SPALLANZANI Biomedical AIDS and Related Research Infection and immunity 13,5 AREA STRATEGICA SCORE. Pagina 66 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349816 Development of anti‐PD‐1 single chain antibodies with finely balanced affinity for effective immunotherapy against HIV ISS Biomedical AIDS and Related Research Infection and immunity 13,5 RF‐2011‐ 02347271 Role of basophils derived interleukin‐4 in driving thymic stromal lymphopoietin dependent pro‐tumor Th2 inflammation in pancreatic cancer SAN RAFFAELE Milano Biomedical Immunology Oncology 13,5 RF‐2011‐ 02347188 Cellular and molecular mechanisms underlying the dyskinetic effects of L‐ DOPA versus Dopamine D2‐D3 agonists SANTA LUCIA Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 13,5 RF‐2011‐ 02348323 Novel clinical and pathogenic insight in the Sicilia interplay between genotype 1 HCV infection and type 2 diabetes. Digestive, Kidney and Urological Systems Infection and immunity 13,5 RF‐2011‐ 02350665 A pathology for the MET oncogene: 'cancers of unknown primary origin' (CUPs) Piemonte Biomedical Oncology 1 ‐ Basic Translational Oncology 13,5 RF‐2011‐ 02351314 A long term control of biofilms and Legionella contamination of dental unit waterline to prevent patients and occupational infections using a natural terpinen‐4 ol. ISS Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 13,5 RF‐2011‐ 02349794 SECURITY STANDARDIZATION AND ADAPTING OF MODERN RADIOTHERAPY THROUGH IN‐VIVO DOSIMETRY Lazio Oncology 2 ‐ Translational Clinical Oncology 13,5 Clinical Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 67 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02351351 Identification of new causative mechanisms underling Brugada Syndrome and advanced functional analysis in patient‐specific induced pluripotent stem‐cell models. SAN RAFFAELE Milano Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 13,5 RF‐2011‐ 02350645 Cell‐on‐Chip technology as an alternative to mouse model to evaluate allergenic potential of airborne substances and of preparations for allergen‐specific immunotherapy. ISS Biomedical Immunology Infection and immunity 13,5 RF‐2011‐ 02352152 Analysis of late radiation damages in terms of neurocognitive outcome after focal radiotherapy for childhood malignant brain tumors by a correlation of absorbed dose levels and magnetic resonance diffusion tensor imaging (DTI) values IST.TUMORI MILANO Oncology 2 ‐ Translational Clinical Oncology 13,5 RF‐2011‐ 02348079 Ostreopsis cf. ovata in Mediterranean fish IZS Umbria e delle Marche and shellfish products: new methods for the early identification of algal toxins, mechanism of action and human risk assessment. Biomedical Veterinary Food safety and animal welfare 13,5 RF‐2011‐ 02347989 Towards an optimization of epigenetic therapy of cancer I.E.O. Biomedical Oncology 1 ‐ Basic Translational Oncology 13,5 RF‐2011‐ 02349866 Unveiling the role of c‐MET and ALK gene alterations as druggable targets in pulmonary sarcomatoid carcinoma, a therapeutically challenging subtype of lung cancer IST.TUMORI MILANO Oncology 2 ‐ Translational Clinical Oncology 13,5 Clinical Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 68 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02347980 An integrated genomic and immunomic analysis of colon cancer to identify unique tumor antigens and parameters of underlying immune response related to disease outcome SAN RAFFAELE Milano Biomedical Immunology Oncology 13,5 RF‐2011‐ 02347782 Randomized pilot phase II study of Lenalidomide as adjuvant therapy for prevention in Hepatocellular carcinoma (HCC) recurrence after radiofrequency thermal ablation (RFA): molecular and immunological prognostic biomarkers Emilia‐Romagna Biomedical Oncology 2 ‐ Translational Clinical Oncology 13,5 RF‐2011‐ 02352261 Glioblastoma Cancer Stem Cells: a tool for identification of new diagnostic/prognostic markers and development of innovative therapeutics CASA SOLLIEVO SOFFERENZA Biomedical Oncology 1 ‐ Basic Translational Oncology 13,5 RF‐2011‐ 02347669 Characterization of cystic fibrosis airway OSPEDALE BAMBINO microbiome in patients showing a severe GESU' decline in lung function and not responding to antimicrobial therapy: a multicentre study Biomedical Infectious Diseases and Microbiology Infection and immunity 13,5 RF‐2011‐ 02350607 Awareness and competence in mild to moderate Alzheimer's disease patients: clinical and forensic implications. Veneto Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 13,5 RF‐2011‐ 02351546 Understanding the interaction between inflammatory factors profile in stroke patients to design a tailored therapeutic approach MONDINO Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13,5 AREA STRATEGICA SCORE. Pagina 69 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02346935 Analysis of hepatitis C virus heterogeneity in direct‐acting antivirals (DAAs) targeted region (non‐structural region 3) during anti‐HCV treatment: new implications for treatment strategy. SAN RAFFAELE Milano RF‐2011‐ 02352796 Computer Assisted Evaluation of Fracture Risk in Tumor Spine Lesions RIZZOLI RF‐2011‐ 02349107 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Infectious Diseases and Microbiology Infection and immunity 13,5 Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering Oncology 13,5 Role of miR‐155 in FLT3 ITD in mutated Sicilia acute myeloid leukemia: studies of network, signalling and silencing Biomedical Oncology 1 ‐ Basic Translational Oncology 13,5 RF‐2011‐ 02352784 Novel Electrochemical Cancer Diagnostics I.E.O. Biomedical Bioengineering Sciences and Technologies Oncology 13,5 RF‐2011‐ 02348907 A novel truncated variant of eNOS as a major risk factor for type 2 diabetes SAN RAFFAELE Milano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 13,5 RF‐2011‐ 02351202 Inhibition of endocannabinoids‐ hydrolyzing enzymes as a new therapeutic target for migraine treatment: studies in animal models and preliminary evaluation in humans MONDINO Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13,5 RF‐2011‐ 02348890 Livestock‐associated methicillin‐resistant Staphylococcus aureus (LA‐MRSA) as cause of human infection and colonization in an Italian Region with high density of pig farming ISS Infectious Diseases and Microbiology Infection and immunity 13,5 Clinical Pagina 70 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02346923 Exploiting the p53‐p66Shc signaling pathway to identify new molecular markers for the prevention of cancerand age‐ related diseases I.E.O. Biomedical Biology of Development and Aging Oncology 13,5 RF‐2011‐ 02346774 HLA‐G expression and DC‐10 as new risk factors for HHV6 reactivation after allo‐ HSCT. SAN RAFFAELE Milano Biomedical Immunology Infection and immunity 13,5 RF‐2011‐ 02351066 THE MENTAL HEALTH OF UNIVERSITY STUDENTS: AN ITALIAN WEB‐BASED SURVEY FATEBENEFRATELLI Risk, Prevention and Health Behavior Neurological diseases 13,5 RF‐2011‐ 02348750 Molecular characterization of human atherosclerotic plaques: role of Calcium‐ Calmodulin dependent kinases and of their activating receptors in vascular wall and infiltrating inflammatory cells. Campania Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 13,5 RF‐2011‐ 02348715 In vitro and in vivo testing of novel therapeutic strategies for lysosomal leukodystrophies: aptamer‐mediated delivery of functional enzymes and gene silencing approaches GASLINI Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 13,5 RF‐2011‐ 02351777 Development of a dedicated ICP‐MS based miR‐sassay to quantify circulating microRNA for the improvement of acute myocardial infarction diagnosis I.N.R.C.A. Biomedical Bioengineering Sciences and Technologies Metabolism disorders and cardiovascular disease 13,5 RF‐2011‐ 02350230 Predictive markers of cardiovascular diseases: role of miRNAs in endothelial damage. AOU San Martino‐IST ‐ Genova Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 13,5 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 71 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02351093 Intestinal microbiota and chronic inflammatory disease in children. Toscana Biomedical Infectious Diseases and Microbiology Infection and immunity 13,5 RF‐2011‐ 02352719 A NOVEL ¿EX VIVO¿ SYSTEM FOR MONITORING THROMBUS FORMATION UNDER FLOW BASED ON ELECTRICAL IMPEDANCE TOMOGRAPHY C.R.O. AVIANO Biomedical Vascular and Hematology The new biotechnologies 13,5 RF‐2011‐ 02346940 An in vitro ad in vivo imaging approach to MONZINO myelin dysfunction and reconstruction after stroke: role of GPR17, a new player in oligodendrocyte specification Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13,5 RF‐2011‐ 02349174 New Therapeutic Approaches for Tuberculosis ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 13,5 RF‐2011‐ 02349812 A randomized intervention trial in breast cancer patients to evaluate a protocol aimed to obtain dietary and physical activity sustainable and permanent modifications in breast cancer patients and its effects on weight and metabolic aspects. Toscana Biomedical Oncology 2 ‐ Translational Clinical Oncology 13,5 RF‐2011‐ 02348475 IMAGE‐BASED PREDICTIVE MODELLING OF TUMOUR RESPONSE AND NOMAL TISSUE COMPLICATONS IN THE RADIOTHERAPY OF PELVIC MALIGNACIES I.E.O. Clinical Oncology 2 ‐ Translational Clinical Oncology 13,5 RF‐2011‐ 02351102 Muscle toxicity of proteasome inhibitor bortezomib Veneto Biomedical Oncology 2 ‐ Translational Clinical Oncology 13,5 AREA STRATEGICA SCORE. Pagina 72 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02348486 Prostaglandin D2 synthase a novel pathway modulating PNS myelination SAN RAFFAELE Milano Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 13,5 RF‐2011‐ 02348733 Tailoring engineered micro‐nanocarriers properties to finely modulate immune responses: the allergy immunotherapy proof of concept ISS Biomedical Immunology Infection and immunity 13,5 RF‐2011‐ 02348487 DNA damage response and metabolic alterations of obesity ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 13,5 RF‐2011‐ 02350366 Genomics, epigenomics and transcriptomic investigation of defective peripheral tolerance in IPEX‐like patients SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics Infection and immunity 13,75 RF‐2011‐ 02352079 IMPACT OF VIDEOTHORACOSCOPIC, ROBOTIC AND OPEN LOBECTOMY ON QUALITY OF LIFE AND IMMUNE RESPONSE IN LUNG CANCER PATIENTS I.E.O. Clinical Oncology 2 ‐ Translational Clinical Oncology 13,75 RF‐2011‐ 02349313 Exploring the functions of the immune system in chronic fatigue syndrome (CFS) by means of silent viral infections and cytokine pathway evaluations and proteomic approach Toscana Clinical Integrative, Functional, and Cognitive Neuroscience Infection and immunity 13,75 RF‐2011‐ 02347031 Development of a wearable system for the integrated assessment of seismocardiogram and other vital signs out of the laboratory setting. DON GNOCCHI Biomedical Bioengineering Sciences and Technologies Metabolism disorders and cardiovascular disease 13,75 AREA STRATEGICA SCORE. Pagina 73 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02349865 Development of immunoassays for the evaluation of human exposure to Aedes mosquitoes: a novel tool for the assessment of efficacy of vector control strategies and estimation of arboviral disease risk. ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 13,75 RF‐2011‐ 02346977 Slow potentials due to glial dysfunction as biomarkers of the seizure‐onset zone in surgically‐remediable focal epilepsies CARLO BESTA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 13,75 RF‐2011‐ 02351853 Tailored screening for colorectal cancer. Piemonte Clinical Risk, Prevention and Health Behavior Oncology 13,75 13,75 AREA STRATEGICA SCORE. Modulating screening interventions on individual risk profile RF‐2011‐ 02350537 Identification of environmental and genetic risk factors in Autism Spectrum Disorders ISS Biomedical Biobehavioral and Behavioral Processes Neurological diseases RF‐2011‐ 02349854 An effective vaccine to prevent mucosal HIV infection based on an HIV‐1 env DNA prime ‐ gp140 trimeric protein boost immunization regimen in the presence of CCL28: proof of efficacy in cynomolgous macaques. SAN RAFFAELE Milano Biomedical AIDS and Related Research Infection and immunity 14 RF‐2011‐ 02347508 Therapy de‐escalation in Inflammatory Bowel Disease ‐ Identification of biomarkers to assess prognostic factors in patients with mucosal healing Sicilia Clinical Digestive, Kidney and Urological Systems Infection and immunity 14 RF‐2011‐ 02346792 Governance of diabetes management in non‐specialistic hospital settings Emilia‐Romagna Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 14 Pagina 74 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347432 Safety and technology assessment of Ultra High Field Magnetic Resonance 7 Tesla System for children applications STELLA MARIS Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 14 RF‐2011‐ 02350805 A National Electronic Library for Oncology (aNELO) REGINA ELENA Biomedical Healthcare Delivery and Methodologies Oncology 14 RF‐2011‐ 02349805 Preclinical characterization of a potent antimicrobial peptide for the development of a new drug for Cystic Fibrosis Toscana Biomedical Infectious Diseases and Microbiology Infection and immunity 14 RF‐2011‐ 02346915 Multifunctional "hybrid" drugs for targeting RIZZOLI skeletal metastases Biomedical Oncology 2 ‐ Translational Clinical Oncology 14 RF‐2011‐ 02349765 IDENTIFICATION OF NOVEL MOLECULAR MECHANISMS IN THE ETHIOPATHOGENESIS OF OVARIAN CANCER Abruzzo Biomedical Oncology 1 ‐ Basic Translational Oncology 14 RF‐2011‐ 02350686 Investigating epigenetic patterns induced by different diets and food for cancer‐ ‐preventive health enhancement I.E.O. Biomedical Genes, Genomes and Genetics Food safety and animal welfare 14 RF‐2011‐ 02346973 Modulating TACE secretase activity and Neuregulin 1 type III signaling to treat inherited hypermyelinating neuropathies SAN RAFFAELE Milano Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 14 RF‐2011‐ 02350795 Immuno‐predictors of cardiovascular risk in ARCISPEDALE‐Reggio patients with psoriatic arthritis Emilia Immunology Metabolism disorders and cardiovascular disease 14 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 75 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348887 Role of local immune response in the development of ano‐genital HPV related invasive diseases Lombardia RF‐2011‐ 02348454 Fosl2 as a p53 antagonist in cancer development and progression C.R.O. AVIANO RF‐2011‐ 02348472 Circulating nucleic acids in colorectal cancer: new non‐invasive tools for patient risk assessment and early diagnosis in high risk individuals RF‐2011‐ 02349625 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Immunology Infection and immunity 14 Biomedical Oncology 1 ‐ Basic Translational Oncology 14 IST.TUMORI MILANO Biomedical Oncology 2 ‐ Translational Clinical Oncology 14 The Hereditary Diffuse Gastric Cancer syndrome: from susceptibility genes to clinical management I.E.O. Biomedical Genes, Genomes and Genetics Oncology 14 RF‐2011‐ 02349925 Composition and dynamics of cholesterol‐ rich membrane microdomains in malaria parasite infection ‐ identification of potential targets for novel intervention strategies ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 14 RF‐2011‐ 02349525 Conventional multi‐port laparoscopic colectomy versus single‐incision colectomy for cancer: comparison of short‐ and long‐ term results by a randomized study Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering Oncology 14 RF‐2011‐ 02348698 Dissection of Pertussis Toxin B‐oligomer (PTB) in adjuvant and anti‐viral components: human and mouse preclinical platforms to the identification of dimers/monomers/minimal domains to be developed as intracellular pathogen adjuvant and anti‐viral molecul ISS Immunology Infection and immunity 14 Clinical Biomedical Pagina 76 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348208 Do anti‐LRP4 antibodies play a pathological CARLO BESTA significance in amyotrophic lateral sclerosis? RF‐2011‐ 02349462 ULTRAsound in ischemic Stroke (ULTRAS) study AOU San Martino‐IST ‐ Genova RF‐2011‐ 02348351 Modulation by IL‐1beta of GABAA and Glutamate Receptors function in human and experimental epilepsy: a novel therapeutic approach for intractable epilepsies. SAN RAFFAELE Pisana‐ Roma RF‐2011‐ 02350154 A minimal residual disease‐driven approach Toscana to the patient affected by follicular lymphoma receiving R‐CHOP RF‐2011‐ 02348916 Neuroactive steroids in Multiple Sclerosis, correlation with immunity and neurodegeneration CARLO BESTA RF‐2011‐ 02348978 Role of the mitogen‐activated protein kinase ERK5 in the development of hepatocellular carcinoma associated with chronic liver injury Toscana RF‐2011‐ 02350106 Clinical validation of an optimized MRI protocol for early diagnosis and monitoring of progressive multifocal leukoencephalopathy SAN RAFFAELE Milano RF‐2011‐ 02349203 Exploring the mechanisms of the Veneto cardiovascular effects of urban air particulate matter in susceptible individuals. Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Immunology Neurological diseases 14 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 14 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 14 Oncology 2 ‐ Translational Clinical Oncology 14 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 14 Biomedical Digestive, Kidney and Urological Systems Oncology 14 Clinical Infectious Diseases and Microbiology Neurological diseases 14 Clinical Cardiovascular and Respiratory Sciences Diseases of environmental origin, with reference also to the workplace 14 Clinical Pagina 77 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02349168 NEW HYBRID POLYMERIC SCAFFOLD FOR OSTEOCHONDRAL ENGINEERED TREATMENT RIZZOLI Biomedical Musculoskeletal, Oral and Skin Sciences The new biotechnologies 14 RF‐2011‐ 02350186 Development of cultured red blood cells with rare phenotypes for diagnostic and clinical use ISS Biomedical Vascular and Hematology The new biotechnologies 14 RF‐2011‐ 02348214 HUMANS AND WILDLIFE: ZOOS IN BETWEEN. ARE ZOOS A THREAT OR BIOSENTINELS FOR INFECTIOUS DISEASES? IZS Piemonte, Liguria e Valle d'Aosta Biomedical Veterinary Food safety and animal welfare 14 RF‐2011‐ 02349858 Investigations on the genetic predisposition to the copper metabolism dysfunction associated with Alzheimer's disease SAN RAFFAELE Pisana‐ Roma Biomedical Genes, Genomes and Genetics Neurological diseases 14 RF‐2011‐ 02347640 Nef protein of HIV‐1 contributes in increasing susceptibility to malaria and opportunistic infections through downregulation of class B scavenger receptor CD36 expression ISS Biomedical AIDS and Related Research Infection and immunity 14 RF‐2011‐ 02347776 Inflammatory environment in patients with peritoneal carcinomatosis from gastrointestinal malignancies undergoing cytoreductive surgery and HIPEC: research of systemic and peritoneal involved factors and development of a murine model SAN RAFFAELE Milano Clinical Oncology 2 ‐ Translational Clinical Oncology 14 RF‐2011‐ 02350548 Estrogenic endocrine disruptors impact on autoimmunity onset and progression: the paradigm of Systemic Lupus Erythematosus ISS Clinical Immunology Infection and immunity 14 AREA STRATEGICA SCORE. Pagina 78 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347810 Advanced diagnosis and therapies for migraine caused by K+ channel dysfunction MONDINO RF‐2011‐ 02347941 SOCIAL INTERACTION AND RIGHT BRAIN DAMAGE IN STROKE PATIENTS AUXOLOGICO RF‐2011‐ 02348502 Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 14 Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 14 Influence of diet on composition of faecal DE BELLIS microbiota and metabolites, metabolomics, in two informative cohorts: African children eating a Western diet. Implications on obesity onset and its control (MICROBESITY) Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 14 RF‐2011‐ 02348437 alpha7‐nAChR status and response to donepezil in Alzheimer's disease patients Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 14 RF‐2011‐ 02348362 Study of the involvement of KDEL receptors Abruzzo in inflammatory bowel disease Biomedical Cell Biology Infection and immunity 14 RF‐2011‐ 02348216 A translational approach to restrain local recurrence in early breast cancer patients C.R.O. AVIANO Biomedical Oncology 1 ‐ Basic Translational Oncology 14 RF‐2011‐ 02350470 New role of S‐nitrosoglutathione reductase (GSNOR) in aging and Alzheimer disease: How epigenetics regulates S‐nitrosylation‐ based signaling and nitrosative stress. SAN RAFFAELE Pisana‐ Roma Biomedical Biology of Development and Aging Neurological diseases 14 RF‐2011‐ 02349707 GENETICS OF ENDOTHELIAL FUNCTION CARLO BESTA IN UNDERSTANDING THE PATHOGENESIS OF LACUNAR STROKE AND SMALL VESSEL DISEASE Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 14 SAN RAFFAELE Pisana‐ Roma Pagina 79 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02349914 Association between long‐term exposure to Piemonte air pollution and neurological and metabolic impairment in adults of two large Italian longitudinal studies Clinical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 14 RF‐2011‐ 02348274 Research of new neuroimaging biomarkers to early identify different epilepsy phenotypes in patients with Tuberous Sclerosis Complex (TSC). OSPEDALE BAMBINO GESU' Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 14 RF‐2011‐ 02349662 Role of Periostin in prostate and breast carcinogenesis. Integrated approaches for the identification of novel prognostic and therapeutic targets. AOU San Martino‐IST ‐ Genova Biomedical Oncology 2 ‐ Translational Clinical Oncology 14 RF‐2011‐ 02347577 Otoacoustic emissions as biomarkers of possible synergistic interaction in inducing hearing damage: an experimental study INAIL Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 14 RF‐2011‐ 02348128 Molecular profiling of laser‐microdissected prostate tissue from prostate cancer patients and not‐yet patients Abruzzo Biomedical Oncology 1 ‐ Basic Translational Oncology 14 RF‐2011‐ 02350961 Integrated panel of biomarkers to evaluate seafood exposure to emerging contaminants along the Ligurian coasts and associated human health risks (IBIDEM) IZS Piemonte, Liguria e Valle d'Aosta Biomedical Veterinary Food safety and animal welfare 14 RF‐2011‐ 02351343 Tissue proteome and secretome of benign and malignant parathyroid tumors: identification of molecular and biochemical biomarkers for early diagnosis of parathyroid cancer Toscana Biomedical Oncology 2 ‐ Translational Clinical Oncology 14 AREA STRATEGICA SCORE. Pagina 80 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02351377 Epidemiological profiles and cost patterns of cancer patients (EpiCost) ISS Biomedical Healthcare Delivery and Methodologies Oncology 14 RF‐2011‐ 02351391 Prevention of haemorrhagic events by minimally invasive monitoring of anticoagulant therapy Toscana Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 14 RF‐2011‐ 02351394 The role of purinome in kidney chronic allograft dysfunction: extracellular ATP as a new possible early marker and trigger of fibrosis Emilia‐Romagna Clinical Digestive, Kidney and Urological Systems The new biotechnologies 14 RF‐2011‐ 02352497 Analysis of Arterial Stiffness in women with Systemic Lupus Erythematosus: correlations with epidemiological, clinical and laboratory parameters, with the presence of hypovitaminosis D and evaluation of the effects of Cholecalciferol supplementation. Toscana Clinical Immunology Infection and immunity 14 RF‐2011‐ 02351045 Molecular signature of the progression of ISS hepatitis C virus (HCV) chronic infection to hepatocellular carcinoma: exosome associated microRNAs and protein profiling in experimental and clinical settings Clinical Oncology 2 ‐ Translational Clinical Infection and immunity 14 RF‐2011‐ 02351979 Genetic disorders of lung vascular development in children:A new, integrated approach for early recognition and molecular diagnosis. OSPEDALE BAMBINO GESU' Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 14 RF‐2011‐ 02352320 A biological prospective study in patients with metastatic pancreatic neuroendocrine tumors treated with everolimus I.E.O. Oncology 2 ‐ Translational Clinical Oncology 14 Biomedical Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 81 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02351438 PRECLINICAL AND CLINICAL PILOT STUDIES TO ACCESS THE SAFETY AND EFFICACY OF THE USE OF HUMAN ADIPOSE TISSUE‐DERIVED MESENCHYMAL STEM CELLS TO PROMOTE TOLERANCE INDUCTION AND LIVER REGENERATION Sicilia Biomedical Immunology The new biotechnologies 14 RF‐2011‐ 02351364 Applied Helicobacter pylori immunoproteomic, molecular and 3D structural approaches in gastric diseases to better understand the process of tumorigenesis and diagnostic biomarker discovery in early stage Gastric cancer C.R.O. AVIANO Biomedical Infectious Diseases and Microbiology Infection and immunity 14 RF‐2011‐ 02351870 Prognostic, risk stratification potentiality and cost‐effectiveness analysis of a multi‐ marker strategy in the management of children with congenital heart disease Toscana Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 14 RF‐2011‐ 02351486 Alternative splicing of PRK2 in Parkinson's disease Sicilia Biomedical Genes, Genomes and Genetics Neurological diseases 14 RF‐2011‐ 02351524 Testing EunetHTA Core Model for national HTA reporting on relevant techonologies AGENAS Biomedical Healthcare Delivery and Methodologies The new biotechnologies 14 RF‐2011‐ 02351488 A PHASE II STUDY OF AUTOLOGOUS BONE MARROW ‐ DERIVED STEM CELL TRANSPLANTATION FOR THE TREATMENT OF CHRONIC END STAGE LIVER DISEASE Emilia‐Romagna Digestive, Kidney and Urological Systems The new biotechnologies 14 Clinical Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 82 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350927 Study of macro‐ and micro‐vascular damage Toscana in patients chronically exposed to cigarette smoking and of the impact of this assessment on the adherence of smokers to smoking cessation programs RF‐2011‐ 02352671 FROM TISSUES TO SERUM IN CANINE MAMMARY CANCER: AN INTEGRATED CONCEPT OF MALIGNANT TUMOR PROGRESSION IZS Umbria e delle Marche RF‐2011‐ 02351491 Peptidomimetic inhibitors of aspartyi proteinases as novel therapeutics to fight mucosal candidiasis RF‐2011‐ 02350874 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease 14 Biomedical Veterinary Oncology 14 Umbria Biomedical AIDS and Related Research Infection and immunity 14 EFFECTS OF NUTRACEUTICAL SPIRULINA ENRICHED‐DIET DURING PREGNANCY AND LACTATION ON NEURODEVELOPMENTAL DISORDERS AND SUSCEPTIBILITY TO INFLAMMATION OF THE PROGENY ISS Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 14 RF‐2011‐ 02351726 Paracrine role of Mesenchymal Stem Cells (MSCs) for cell therapy in ALS Piemonte Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 14 RF‐2011‐ 02351155 Mental and physical health status of workers receiving redundancy payment Piemonte Clinical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 14 RF‐2011‐ 02351152 Topical propranolol administration to preserve visual function in newborns with retinopathy of prematurity. Toscana Cell Biology Neurological diseases 14 Biomedical Pagina 83 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351150 New insight in the prevention of knee osteoarthritis progression: correlation between joint biomechanics and molecular cartilage homeostasis RIZZOLI RF‐2011‐ 02352255 Developmental Coordination Disorder in school‐age children born very preterm: validation of a screening tool and relationship with ante‐ and peri‐natal events. OSPEDALE BAMBINO GESU' RF‐2011‐ 02351125 Multifactorial study, with metabolomic profiling and circulating tumor cell characterization, of microscopic residual disease and its evolution after surgery for early breast cancer IRST Meldola RF‐2011‐ 02349813 DEVELOPMENT OF A FULL WIRELESS POLYGRAPHIC DEVICE FOR DIAGNOSIS OF SLEEP DISORDERS AND REMOTELY ATTENDED HOME MONITORING AUXOLOGICO RF‐2011‐ 02348463 CARLO BESTA Can epilepsy affect the structure of the brain? Role of neurons and glia and effect of therapy in a model of epileptogenicbrain malformation RF‐2011‐ 02352272 Longitudinal assessment of chemotherapy‐ induced impairment of cognitive function and its correlation with structural changes in the cerebral white matter of patients with non‐small cell lung cancer (NSCLC). AOU San Martino‐IST ‐ Genova Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Musculoskeletal, Oral and Skin Sciences The new biotechnologies 14 Biobehavioral and Behavioral Processes Neurological diseases 14 Oncology 2 ‐ Translational Clinical Oncology 14 Clinical Emerging Technologies and Training in Neurosciences Neurological diseases 14,25 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 14,25 Oncology 2 ‐ Translational Clinical Oncology 14,25 Clinical Biomedical Clinical Pagina 84 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02352311 Searching for genetic profiles associated with IgE variability in health care workers and bakers exposed to occupational allergens Veneto Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 14,25 RF‐2011‐ 02349426 Preclinical study in mouse models to evaluate the use of the chemokine Cxcl3 in the therapy of medulloblastoma SANTA LUCIA Biomedical Oncology 1 ‐ Basic Translational Oncology 14,25 RF‐2011‐ 02351439 STUDY ON THE ANTIDEPRESSANT ACTIVITY OF FINGOLIMOD IN EXPERIMENTAL ANIMAL MODELS AND PATIENTS WITH MULTIPLE SCLEROSIS NEUROMED Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 14,5 RF‐2011‐ 02347800 Novel molecular and cellular pathophysiological mechanisms of diabetic vascular disease Abruzzo Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 14,5 RF‐2011‐ 02347219 Heart remodelling in Chronic Obstructive Pulmonary Disease: diagnostic and therapeutic implications. Emilia‐Romagna Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 14,5 RF‐2011‐ 02347204 GENETIC PREVENTION OF LYMPHOMA DEVELOPMENT IN p53 KNOCKOUT MICE REVEALS A NOVEL MOUSE MODEL OF OSTEOSARCOMA AND HEMANGIOSARCOMA. EARLY MOLECULAR AND IMMUNOLOGICAL MECHANISMS INVOLVED IN TUMOR ONSET AND MALIGNANCY AS TARGET OF INNOVATIVES THERAPIES. RIZZOLI Biomedical Oncology 1 ‐ Basic Translational Oncology 14,5 AREA STRATEGICA SCORE. Pagina 85 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351890 Prevention interventions for promoting the health of men who have sex with men (MSM) in Palermo area. Sicilia RF‐2011‐ 02348554 Molecular and Clinical study of next generation in Autism‐Epilepsy Phenotype: Focus on Astrocyte‐Neuron interaction. STELLA MARIS RF‐2011‐ 02348556 A novel approach to diagnosis, allocation and treatment of HCC SAN MATTEO RF‐2011‐ 02349276 Characterization of the mitochondrial oxidative defect in Spinal Muscular Atrophy. Investigation of the molecular pathways leading to mitochondrial dysfunction and their relation to Spinal Muscular Atrophy pathogenesis. MAGGIORE RF‐2011‐ 02351156 Serum miRNAs as circulating biomarkers for the early diagnosis of ovarian cancer I.E.O. RF‐2011‐ 02349941 Investigation of mechanism of tumor development and new systemic drug treatment strategies to tackle the rising burden of hepatocellular carcinoma complicating Non Alcoholic Fatty Liver Disease. RF‐2011‐ 02351850 Genotype‐phenotype correlation in schizophrenia: role of rare variants Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Infectious Diseases and Microbiology Infection and immunity 14,5 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 14,5 Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering Oncology 14,5 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 14,5 Clinical Oncology 2 ‐ Translational Clinical Oncology 14,5 Emilia‐Romagna Biomedical Oncology 2 ‐ Translational Clinical Oncology 14,5 FATEBENEFRATELLI Biomedical Biobehavioral and Behavioral Processes Neurological diseases 14,5 Pagina 86 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02350046 COronary endothelium and systemic METabolism crosstalk in the progression of cardiac dysfunction. CO‐MET study Toscana Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 14,5 RF‐2011‐ 02350034 Characterization of colon cancer stem cells for the identification of new prognosticmarkers and/or targets for novel anticancer therapies Basilicata Biomedical Oncology 1 ‐ Basic Translational Oncology 14,5 RF‐2011‐ 02348525 Involvement of mutant p53 gain of function in tumor microenvironment REGINA ELENA Biomedical Oncology 1 ‐ Basic Translational Oncology 14,5 RF‐2011‐ 02349450 Role of autophagy and its regulators in melanoma and in the differential therapeutic response to BRAF‐inhibitors Toscana Biomedical Oncology 1 ‐ Basic Translational Oncology 14,5 RF‐2011‐ 02351319 Treatment of early osteoarthritis by death‐ inducible, IL‐10 expressing adipose‐derived stem cells: a novel, safe, anti‐inflammatory and regenerative approach. GALEAZZI Biomedical Musculoskeletal, Oral and Skin Sciences The new biotechnologies 14,5 RF‐2011‐ 02348017 PRE‐TRANSPLANT GRAFT RECONDITIONING WITH MESENCHYMAL STROMAL CELLS IN EXPERIMENTAL KIDNEY TRANSPLANTATION SAN MATTEO Biomedical Digestive, Kidney and Urological Systems Infection and immunity 14,5 RF‐2011‐ 02351064 ALTERED HOST‐MICROBE INTERACTION IN HIV: A POTENTIAL TARGET FOR INTERVENTION WITH PROBIOTICS Lombardia AIDS and Related Research Infection and immunity 14,5 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 87 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02352161 Innovative diagnostic tools for the control of patulin in the agri‐food chain ISS Biomedical Veterinary Food safety and animal welfare 14,5 RF‐2011‐ 02347544 Studies on the molecular characteristics of ISS the Env protein from HIV‐1 subtypes and recombinant forms circulating in Cameroon and their correlation with disease stage, virus infectivity and resistance to neutralization Biomedical AIDS and Related Research Infection and immunity 14,5 RF‐2011‐ 02347507 PTPRG as a new candidate biomarker for Chronic Myeloid Leukemia Sardegna Biomedical Oncology 1 ‐ Basic Translational Oncology 14,5 RF‐2011‐ 02347497 Cortical TRPV1 in neuroglial network: a new tool for studying neuropathic pain SANTA LUCIA Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 14,5 RF‐2011‐ 02350512 High throughput technologies for uncovering new diagnostic biomarkers involved in the accelerated vascular ageing of patients with chronic kidney disease Puglia Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 14,5 RF‐2011‐ 02349818 Biomarkers and Asphyxia Piemonte Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 14,5 RF‐2011‐ 02349696 Pathogenesis of hemolytic uremic syndrome associated with Shiga toxin‐ producingEscherichia coli infections: early enrolment of patients with bloody diarrhea, application of over‐hydration protocols, and study of the kinetic of the toxins in blood ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 14,5 AREA STRATEGICA SCORE. Pagina 88 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347913 Circulating microRNAs associated to cardiac‐derived microparticles and their role in endothelial dysfunction: age‐ dependence of their expression in stable angina patients and following acute myocardial infarction I.N.R.C.A. Biomedical RF‐2011‐ 02349208 Mucosal and Systemic immunological and genetic correlates of HIV resistance in exposed HIV‐seronegative individuals Lombardia Clinical RF‐2011‐ 02347604 Type 3 ryanodine receptor in post‐stroke recovery: genetic, cellular and functional study. CARLO BESTA RF‐2011‐ 02351133 Rehabilitative Homework tool in young adults with Down syndrome to prevent cognitive decline: neuropsychological and clinical study. RF‐2011‐ 02351263 Classificazione 1 Liv. AREA STRATEGICA SCORE. Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 14,5 AIDS and Related Research Infection and immunity 14,5 Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 14,5 STELLA MARIS Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 14,5 Educational intervention to reduce sugar‐ sweetened beverages purchase at the supermarket. A community trial. Piemonte Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 14,5 RF‐2011‐ 02351948 Adolescents and young adults with cancer in Italy (AYACI) IST.TUMORI MILANO Clinical Population Sciences and Epidemiology Oncology 14,5 RF‐2011‐ 02351013 Improving appropriateness of biopharmaceutical treatments in Multiple Sclerosis: early identification of non responders, dosage and timing redefinition, mechanism of action and neurotoxicity of an "old" and a "new" drugs. Piemonte Brain Disorders and Clinical Neuroscience Neurological diseases 14,5 Biomedical Pagina 89 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02351056 Epigenetic analyses in heart failure Piemonte Biomedical RF‐2011‐ 02348667 Intraoperative Calcitonin Monitoring as marker of disease cure after surgery and indicator of type of surgery in patients withMedullary Thyroid Cancer PASCALE Clinical RF‐2011‐ 02349062 Role of microRNA regulation by estrogen receptor beta in hormone‐responsive breast cancer PASCALE RF‐2011‐ 02350663 Involvement of p63 in tumor development, invasion and metastasis, and its relationship with the other members of the p53 family RF‐2011‐ 02350653 Classificazione 1 Liv. AREA STRATEGICA SCORE. Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 14,5 Oncology 2 ‐ Translational Clinical Oncology 14,5 Biomedical Oncology 1 ‐ Basic Translational Oncology 14,5 IDI Biomedical Cell Biology Oncology 14,5 Erdheim‐Chester disease at the crossroad between clonality and inflammation: implications for therapy SAN RAFFAELE Milano Biomedical Immunology Infection and immunity 14,5 RF‐2011‐ 02350790 Evaluation of the antitumor response of a co‐treatment with LHRH analogues in women with endometrial cancer at the initial diagnosis Toscana Oncology 2 ‐ Translational Clinical Oncology 14,5 RF‐2011‐ 02350722 Role of transmembrane chemokines in neuroprotection following brain ischemia NEUROMED Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 14,5 RF‐2011‐ 02352717 Employment of mesenchymal stem cells as vectors for prodrug activating enzymes in prostate cancer therapy SAN RAFFAELE Milano Biomedical Oncology 1 ‐ Basic Translational Oncology 14,5 Clinical Pagina 90 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350642 Prediction of preeclampsia:a proteomic approach for identification of novel biomarkers ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Infection and immunity 14,5 RF‐2011‐ 02349127 Melanocortin‐1 receptor as a regulator of proliferation pathways in melanoma SAN GALLICANO Biomedical Oncology 1 ‐ Basic Translational Oncology 14,5 RF‐2011‐ 02348665 Identification of novel therapeutic targets to halt HCV infection: a proteomic approach. SPALLANZANI Biomedical Infectious Diseases and Microbiology Infection and immunity 14,5 RF‐2011‐ 02347883 Regulation of kinetochore activity by the conserved cell cycle kinase Rio1 I.E.O. Biomedical Cell Biology Oncology 14,75 RF‐2011‐ 02349791 Sentinel animals to monitor asbestos Piemonte pollution around the former Balangero mine Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 14,75 RF‐2011‐ 02348154 DEVELOPMENT AND CLINICAL APPLICATION OF A NEW BETA PROBE FOR RADIOGUIDED SURGERY IN MENINGIOMA TUMOR CARLO BESTA Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering Neurological diseases 14,75 RF‐2011‐ 02350754 Role of metabotropic glutamate receptor in absence epilepsy NEUROMED Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 14,75 RF‐2011‐ 02346752 Genetic and immunological factors involved ISS in natural resistance to lentiviral infection Biomedical Immunology Infection and immunity 14,75 RF‐2011‐ 02349250 DEVELOPMENT OF NEW DIAGNOSTIC TOOLS FOR THE DETECTION OF ONCOGENIC POLYOMAVIRUSES IN HUMAN TUMORS. Biomedical Infectious Diseases and Microbiology The new biotechnologies 14,75 Emilia‐Romagna Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 91 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02348140 Levosimendan in high risk patients undergoing non cardiac surgery. A randomized study. SAN RAFFAELE Milano Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering Metabolism disorders and cardiovascular disease 15 RF‐2011‐ 02349076 Assessment and management of cardiovascular risk in perimenopausal women undergoing breast cancer screening AUXOLOGICO Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 15 RF‐2011‐ 02346876 Stimulating the left Broca's area to rehabilitate verbal communicative abilities in severe post‐stroke aphasia SANTA LUCIA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 15 RF‐2011‐ 02347511 GENETIC REGULATION OF PLASMA LOW DENSITY LIPOPROTEIN LEVELS. EFFECT OF MUTATIONS OF APOB AND ANGPTL3/8 GENES ON HEPATIC SECRETION OF APOB‐CONTAINING LIPOPROTEINS. Emilia‐Romagna Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 15 RF‐2011‐ 02351048 Marine omega‐3 fatty acids and vitamin D for QTc prolongation in people with psychosis on antipsychotic drugs. SAN MATTEO Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 15 RF‐2011‐ 02352063 Biomarkers in Glaucoma. BIETTI Biomedical Brain Disorders and Clinical Neuroscience Infection and immunity 15 RF‐2011‐ 02349090 Bisphenol A, obesity and breast cancer: epidemiological, clinical, analytical and biological approach PASCALE Biomedical Oncology 1 ‐ Basic Translational Oncology 15 RF‐2011‐ 02346898 Burden of alcohol‐related diseases and priorities for health policy control. ISS Biomedical Population Sciences and Epidemiology Oncology 15 AREA STRATEGICA SCORE. Pagina 92 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02348228 Molecular analysis of Streptococcus pneumoniae and Neisseria meningitidis serotypes/serogroups and potential coverage of available vaccines. RF‐2011‐ 02347308 DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Immunology Infection and immunity 15 Biochemical, electrophysiological and Sicilia genetic determinants of disease progression and survival in Amyotrophic Lateral Sclerosis (ALS) Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 15 RF‐2011‐ 02347297 TARGETING CD99 TO TREAT EWING SARCOMA RIZZOLI Biomedical Oncology 2 ‐ Translational Clinical Oncology 15 RF‐2011‐ 02351583 Acute coronary syndromes in diabetic and non‐diabetic patients: differences in the inflammatory, immunological, and coagulation events. Campania Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 15 RF‐2011‐ 02350460 Genetics of dementia: transcriptional profiles in leukocytes for the identification of biomarkers associated to disease onset, phenotype and progression. FATEBENEFRATELLI Biomedical Biobehavioral and Behavioral Processes Neurological diseases 15 RF‐2011‐ 02351646 Assessment of animal welfare in extensive farms of Mediterranean Area: dairy ewes and buffaloes IZS Sardegna Biomedical Veterinary Food safety and animal welfare 15 RF‐2011‐ 02350842 In search of new drugs and drug‐targets for the diagnosis and therapy of Invasive Fungal Infections (IFIs) ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 15 Toscana Pagina 93 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347679 Azacitidine, Depsipeptide and IFN‐alpha (ADI)‐combined treatment of colorectal cancer (CRC): depicting the therapeutic cross‐talk between epigenetic and IFN signatures ISS Biomedical Oncology 2 ‐ Translational Clinical Oncology 15 RF‐2011‐ 02351712 Use of polydeoxyribonucleotide for treating diabetic foot ulcers Sicilia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 15 RF‐2011‐ 02352273 Telemonitoring in Pediatric Patients with Heart Failure and VAD ISS Biomedical Bioengineering Sciences and Technologies Metabolism disorders and cardiovascular disease 15 RF‐2011‐ 02352893 Atherosclerotic effects of chronic low dose radiation exposure assessed with an integrated clinical, cellular and experimental approach: The Interventional Cardiologist Radiation Study Lombardia Biomedical Cardiovascular and Respiratory Sciences Diseases of environmental origin, with reference also to the workplace 15 RF‐2011‐ 02349952 Significance of Sentinel Node Micrometastasis in Breast Cancer Progression C.R.O. AVIANO Oncology 2 ‐ Translational Clinical Oncology 15 RF‐2011‐ 02352263 Meta‐analytic assessment of mesenchymal stem cell genomic features in soft tissue sarcomas: a link to cancer dormancy and micro‐metastatic spread for improved prognosis and response to the therapy assessment IST.TUMORI MILANO Genes, Genomes and Genetics Oncology 15 Clinical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 94 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351071 Cellular and Molecular events related to neuroprotection and modulation of endogenous neurogenesis: role of estrogens in an in vivo model of hippocampal neurodegeneration. SAN RAFFAELE Pisana‐ Roma RF‐2011‐ 02351680 A diagnostic and therapeutic consensus approach to multiple sclerosis in the neurological network of Verona province Veneto RF‐2011‐ 02351776 Comparison of the long‐term efficacy of Campania bariatric surgery and new antidiabetic (GLP‐ 1 based) therapy on diabetes remission and cardiovascular risk profile in obese type 2 diabetic patients RF‐2011‐ 02351660 ARIEL‐ Air Pollution and Cardiovascular Risk Investigations: the Epigenomic Link RF‐2011‐ 02351296 Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 15 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 15 Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 15 MAGGIORE Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 15 Molecular identification of new poor prognostic subgroups of childhood Acute Lymphoblastic Leukemia as candidate for targeted therapies Lombardia Biomedical Oncology 2 ‐ Translational Clinical Oncology 15 RF‐2011‐ 02349056 The effect of metabolic surgery on the immunometabolome profile in non obese type 2 diabetic patients SAN RAFFAELE Milano Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 15 RF‐2011‐ 02350774 Targeting inflammasome for seizure prevention CARLO BESTA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 15 Pagina 95 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348210 Cognitive dysfunction after general anesthesia in the elderly: a transient, reversible phenomenon or the harbinger of Alzheimer disease? CARLO BESTA RF‐2011‐ 02350256 18F‐AH‐111585 PET/CT in the diagnosis and evaluation of tumor angiogenesis in primary brain tumors HUMANITAS RF‐2011‐ 02346851 Antimicrobial Microbubbles (MBs) for treatment of biofilm‐associated infections ISS RF‐2011‐ 02350124 THE ROLE OF THE GUT MICROBIOTA IN ALZHEIMER'S DISEASE PATHOGENESIS FATEBENEFRATELLI RF‐2011‐ 02351555 Methylene blue in hypotensive vasoplegic patients. A randomized trial. RF‐2011‐ 02350569 RF‐2011‐ 02347230 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Brain Disorders and Clinical Neuroscience Neurological diseases 15 Oncology 2 ‐ Translational Clinical Oncology 15 Biomedical Bioengineering Sciences and Technologies Infection and immunity 15 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 15 SAN RAFFAELE Milano Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering Metabolism disorders and cardiovascular disease 15 A MULTICENTRE PHASE II RANDOMIZED STUDY OF FULVESTRANT VERSUS FULVESTRANT + METFORMIN AS FIRST‐ AND SECOND‐LINE ENDOCRINE TREATMENT IN NON DIABETIC POSTMENOPAUSAL WOMEN WITH HORMONE RECEPTOR POSITIVE, HER‐2 NEGATIVE ADVANCED BREAST CANCER. THE META TRIAL. REGINA ELENA Clinical Oncology 2 ‐ Translational Clinical Oncology 15 The role of Iron in White Matter changes in Neurodegenerative Diseases (Alzheimer, Parkinson and Huntington's Diseases). Does the white matter share with the gray matter the same physiopathology (iron accumulation)? SANTA LUCIA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 15 Clinical Pagina 96 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349354 DNA replication licensing in Plasmodia: molecular characterisation of a potential new therapeutic target for malaria treatment. ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 15 RF‐2011‐ 02351484 Evaluation of rubella immunity among pregnant women and development and evaluation of a postpartum and post‐ abortion rubella vaccination protocol in a sample of Italian hospitals ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 15 RF‐2011‐ 02349134 New biomarkers to predict prognosis and tailor systemic therapy in patients with Pseudomyxoma Peritonei IST.TUMORI MILANO Oncology 2 ‐ Translational Clinical Oncology 15 RF‐2011‐ 02349296 Combined study of genomic CNVs and immunological profiles in a population of patients with Autistim Spectrum Disorders (ASD) AUXOLOGICO Biomedical Genes, Genomes and Genetics Neurological diseases 15 RF‐2011‐ 02348704 Zinc Finger Protein 423 as a candidate gene for Autism Spectrum Disorder susceptibility ‐ a comprehensive analysis in mouse mutants and autistic children. SAN RAFFAELE Milano Biomedical Biobehavioral and Behavioral Processes Neurological diseases 15 RF‐2011‐ 02347107 Upper limb impairment in Charcot‐Marie‐ Tooth patients: motor strategies, impact on quality of life and cortical functional reorganization DON GNOCCHI Clinical Musculoskeletal, Oral and Skin Sciences Neurological diseases 15 RF‐2011‐ 02348635 Charcot Foot: whole genome analysis and inflammatory evaluation for the development of potential treatment strategies I.N.R.C.A. Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 15 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 97 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02346956 Association between environmental Campania exposure to chemical pollutants and the development of neurodegenerative diseases: a clinical epidemiological study combinated with environmental and biomolecular observations in contaminated Terzigno area Biomedical Brain Disorders and Clinical Neuroscience Diseases of environmental origin, with reference also to the workplace 15 RF‐2011‐ 02351018 Risk of cardiovascular disease in breast cancer patients: a population based study Biomedical Population Sciences and Epidemiology Oncology 15 RF‐2011‐ 02349403 Identification of genetic determinants for I.E.O. cetuximab‐induced immunogenic cell death and response to treatment Clinical Oncology 2 ‐ Translational Clinical Oncology 15 RF‐2011‐ 02349247 INNOVATIVE TREATMENTS FOR OSTEOSARCOMA: VALIDATION OF PROTEIN KINASE INHIBITORS AS TARGETED DRUGS AND ABC TRANSPORTERS INTERACTING AGENTS Biomedical Oncology 2 ‐ Translational Clinical Oncology 15 RF‐2011‐ 02347866 RF‐2011‐ 02352697 DESTINATARIO ISTITUZIONALE Toscana RIZZOLI Tipologia AREA STRATEGICA SCORE. SPALLANZANI Clinical Infectious Diseases and Microbiology Infection and immunity 15,25 S.CAMILLO Clinical Biobehavioral and Behavioral Processes Neurological diseases 15,25 A registry of intravenous artesunate for severe malaria in returning travelers from endemic countries: pharmacokinetic data, adverse events, and clinical outcome. NetwOrk for severe MALaria treatment ‐ NOMAL study Behavioral and neurofunctional markers of spatial awareness deficits during multi‐ tasking: Implications for diagnosis and rehabilitation of right hemisphere stroke patients Classificazione 1 Liv. Pagina 98 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347087 HIV‐TLR4 interaction as a novel target for intervention strategies against HIV disease ISS RF‐2011‐ 02348308 Mild cognitive impairment and progression to Alzheimer's disease: association with herpes viruses infections. Emilia‐Romagna RF‐2011‐ 02352605 Generation and validation of a new breast cancer prognostic signature by RNAseq‐ based translatome profiling. Provincia autonoma Trento Biomedical RF‐2011‐ 02347561 BRAIN MACHINE INTERFACE (BMI) IN PARALYSIS S.CAMILLO RF‐2011‐ 02347982 Spinal cord modular organization in recovery and back to work management of ataxic subjects INAIL RF‐2011‐ 02352180 Exome sequencing in Individuals with CASA SOLLIEVO Developmental Delay/Intellectual Disability SOFFERENZA of Unknown Etiology RF‐2011‐ 02351338 Project Title: Development of a dedicated evaluation track within the Hospital and a network between the Hospital and family doctors for the identification, evaluation and management of patients with osteoporotic fractures Toscana RF‐2011‐ 02348799 Stereotactic body radiotherapy as monotherapy or boost combined with externalbeam radiotherapy for localized prostate cancer IST.TUMORI MILANO Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. AIDS and Related Research Infection and immunity 15,25 Brain Disorders and Clinical Neuroscience Neurological diseases 15,25 Oncology 1 ‐ Basic Translational Oncology 15,25 Clinical Biobehavioral and Behavioral Processes Neurological diseases 15,5 Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 15,5 Biomedical Genes, Genomes and Genetics The new biotechnologies 15,5 Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 15,5 Clinical Oncology 2 ‐ Translational Clinical Oncology 15,5 Clinical Pagina 99 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351307 A Next‐Generation Sequencing approach to assess blood‐based transcriptomic biomarkers in Coronary Artery Disease MONZINO RF‐2011‐ 02349167 GENETIC AND NEUROBIOLOGICAL INFLUENCES ON RISK‐TAKING PROPENSITY ISS RF‐2011‐ 02352178 Multimodal evaluation of stroke patient's mindbrain state during upper‐limb robot‐ aided therapy SAN RAFFAELE Pisana‐ Roma RF‐2011‐ 02348971 Development of a diagnostic, histopathologic and therapeutic program for the management of gastrointestinal motor disorders in Parkinson disease: proposal of a new translational collaborative approach Toscana RF‐2011‐ 02348657 Development and validation of predictive models of toxicity after radiotherapy for prostate cancer based on large data‐bases from clinical trials SAN RAFFAELE Milano RF‐2011‐ 02351222 EGFR‐TK inhibitors vs Chemotherapy: Improving Treatment Selection for Non Small Cell Lung Cancer (NSCLC) Patients using VeristratTM Serum Proteomic Profile Classification and Serum Amyloid A RF‐2011‐ 02346756 Surveillance, control and prevention of infections by multidrug resistant organisms in alternative healthcare settings: nursing and residential homes Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 15,5 Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 15,5 Clinical Emerging Technologies and Training in Neurosciences Neurological diseases 15,5 Clinical Digestive, Kidney and Urological Systems Neurological diseases 15,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 15,5 SAN RAFFAELE Milano Clinical Oncology 2 ‐ Translational Clinical Oncology 15,5 Sicilia Clinical Healthcare Delivery and Methodologies Infection and immunity 15,5 Biomedical Pagina 100 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349264 Insights into epigenetic changes in hepatocellular carcinoma and rationales for their therapeutic targeting RF‐2011‐ 02348928 OSPEDALE BAMBINO Innovative strategies for preventing GESU' emergence and transmission of multi drug resistantGram negative bacteria in hospitalized newborns, infants, and children RF‐2011‐ 02349857 BONE AND MUSCLE IN SPINAL AUXOLOGICO MUSCULAR ATROPHY: FROM BENCH TO BEDSIDE. RF‐2011‐ 02347855 The role of the EGFR in the interaction between mesenchymal stem cells and breast cancer cells: implications for novel therapeutic approaches PASCALE RF‐2011‐ 02349826 Structural connectivity in DYT1 and DYT6 dystonia CARLO BESTA RF‐2011‐ 02346772 Novel therapeutic strategies for Amyotrophic Lateral Sclerosis: testing the efficacy of cell‐permeable peptides in preclinical models. MAUGERI RF‐2011‐ 02349896 HIV‐infected pregnant women treated with HAART: registry of pharmacokinetic parameters of new and commonly used antiretrovirals; mitochondrial toxicity and apoptosis in pregnant women and utero‐ exposed newborn SPALLANZANI Emilia‐Romagna Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 1 ‐ Basic Translational Oncology 15,5 Population Sciences and Epidemiology Infection and immunity 15,5 Biomedical Musculoskeletal, Oral and Skin Sciences Neurological diseases 15,5 Biomedical Oncology 1 ‐ Basic Translational Oncology 15,5 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 15,5 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 15,5 AIDS and Related Research Infection and immunity 15,5 Clinical Clinical Pagina 101 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352228 PROGNOSTIC ROLE OF SAN DONATO CARDIOPULMONARY EXERCISE STRESS TEST IN MODERATE‐TO‐SEVERE AORTIC STENOSIS RF‐2011‐ 02349788 Increased severity of respiratory viral infections in the elderly: identification of thiols level as biomarker and therapeutic target. SAN RAFFAELE Pisana‐ Roma RF‐2011‐ 02346793 Eukaryotic translation Initiation Factor 4H /Wbscr1: its role in gametogenesis, fertility and gonadal carcinogenesis RF‐2011‐ 02352307 Tipologia AREA STRATEGICA SCORE. Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 15,5 Biomedical Infectious Diseases and Microbiology Infection and immunity 15,5 SAN RAFFAELE Milano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies 15,5 EVALUATION OF THE ACTIVITY OF A NOVEL PARTIAL AGONIST OF A1 ADENOSINERECEPTOR AS POTENTIAL THERAPEUTIC AGENT FOR DIABETES AND OBESITY Abruzzo Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 15,5 RF‐2011‐ 02350657 Novel biological agents for the treatment of hormone‐refractory prostate cancer AOU San Martino‐IST ‐ Genova Biomedical Oncology 1 ‐ Basic Translational Oncology 15,5 RF‐2011‐ 02351922 Clinical and neurobiological correlates of MONDINO repetitive transcranial magnetic stimulation (rTMS) in Alzheimer's disease Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 15,5 RF‐2011‐ 02352284 Pathophysiologic and prognostic role of OXidative stress in acute coronarY sindromes: GENder differences [OXYGEN trial] Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 15,5 Lazio Clinical Classificazione 1 Liv. Clinical Pagina 102 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349128 Avian reservoirs as a potential source of human extraintestinal pathogenic Escherichia coli ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 15,5 RF‐2011‐ 02348719 Masked mycotoxins in cereal‐based food products. Analytical methods, evaluation of their occurrence and risk assessment: an emerging issue for food safety? IZS Venezie Biomedical Veterinary Food safety and animal welfare 15,5 RF‐2011‐ 02348256 Molecular characterization of the T cell dysfunctions during HIV infection to evaluate immune restoration after HAART and plan new immunotherapeutic strategies Emilia‐Romagna Biomedical AIDS and Related Research Infection and immunity 15,5 RF‐2011‐ 02347345 Identification of early neurophysiological markers of cognitive‐behavioural disturbances in patients with cerebrovascular disease. Sicilia Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 15,5 RF‐2011‐ 02351004 Postoperative radiotherapy to the chest wall Umbria or the breast plus draining nodes in breast cancer patients: dosimetric comparison between 3DCRT, IMRT, helical tomotherapy and TomoDirect tomotherapy. Clinical Oncology 2 ‐ Translational Clinical Oncology 15,5 RF‐2011‐ 02349571 Cerebral Amyloid Angiopathy: new markers AUXOLOGICO for early diagnosis and insights in pathogenetic mechanism Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 15,5 RF‐2011‐ 02348100 Impact of defective DNA repair of oxidative damage on the immune response and relevance for colorectal cancer Oncology 1 ‐ Basic Translational Oncology 15,5 ISS Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 103 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349205 Cell characterization and analysis of the proliferative/differentiative potential of human coelomic fluid cells for "in utero"haematopoietic stem cell transplantation in haemoglobinopathies Sicilia RF‐2011‐ 02351010 Glioma‐associated stem cells: an innovative patient based approach for prognostic, predictive and therapeutic purposes. Friuli‐Venezia Giulia RF‐2011‐ 02351783 Sleep‐wake cycle and Sundown Syndrome in Alzheimer Disease: role of the orexinergic system and relationships with neurodegeneration biomarkers RF‐2011‐ 02348300 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Vascular and Hematology The new biotechnologies 15,5 Clinical Brain Disorders and Clinical Neuroscience Oncology 15,5 SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 15,5 Cross‐talk between innate and adaptive immunity as a target for therapeutic immune intervention in the early phases of psoriasis pathogenesis ISS Biomedical Immunology Infection and immunity 15,5 RF‐2011‐ 02350388 Cell Stess Derived Primary Cell Transformation SDN Biomedical Oncology 1 ‐ Basic Translational Oncology 15,5 RF‐2011‐ 02351053 NEW BIOMARKERS IN WORKERS EXPOSED TO INORGANIC ARSENIC MAUGERI Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 15,5 RF‐2011‐ 02351944 Focal Cortical Dysplasia Type I and Type II: Identification of causative genes and elucidation of disease pathomechanisms Toscana Brain Disorders and Clinical Neuroscience Neurological diseases 15,5 Clinical Pagina 104 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347480 ANTI‐INFLAMMATORY ACTIVITY OF POLYPHENOLS IN CANCER CHEMOPREVENTION: IN VITRO AND IN VIVO STUDIES RF‐2011‐ 02347471 New frontiers in breast imaging: contrast I.E.O. enhanced digital mammography. ‐ Clinical performance of contrast‐enhanced spectral mammography (CESM ‐ SenoBright) in pre‐ surgical evaluation of extent of malignancy in a population of women with breast cancer RF‐2011‐ 02351454 Microglial markers of central sensitization in neuropathic pain. A translational study Veneto RF‐2011‐ 02351920 PAIN‐ASSOCIATED CORTICAL HEMODYNAMIC PERTURBATION IN PRETERM NEWBORNS AND ITS RELATION WITH NEURODEVELOPMENTAL OUTCOME BURLO GAROFALO RF‐2011‐ 02349416 Role of the menstrual cycle and of sexual hormones in HIV‐1 infection of human cervico‐vaginal tissue explants SAN RAFFAELE Milano RF‐2011‐ 02349083 Molecular Biomarkers for Colorectal Liver Metastases Resectability after Chemotherapy with Cetuximab REGINA ELENA RF‐2011‐ 02350459 Impact of Carotid Endarterectomy and STenting on RhEological parameters and Autonomic Modulation (ICE‐STREAM study). SAN RAFFAELE Milano ISS Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 15,5 Oncology 2 ‐ Translational Clinical Oncology 15,5 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 15,5 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 15,5 AIDS and Related Research Infection and immunity 15,5 Clinical Oncology 2 ‐ Translational Clinical Oncology 15,5 Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering Metabolism disorders and cardiovascular disease 15,5 Clinical Biomedical Pagina 105 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349515 HIGH THROUGHPUT TECNOLOGIES Puglia FOR UNCOVERING NEW DIAGNOSTIC BIOMARKERS FOR EARLY DIAGNOSIS OF CHRONIC ALLOGRAFT INJURY IN RENAL TRANSPLANTATION (CAI) RF‐2011‐ 02349543 Automated Good Manufacturing Production of Adipose‐derived Mesenchymal Stem Cells for clinical use: validation, characterization and biosafety. RIZZOLI RF‐2011‐ 02352071 Pharmacological resistance in pituitary tumours: insights from the study of Aryl hydrocarbon Receptor Interacting Protein (AIP) as a new mediator of somatostatin analogues Abruzzo RF‐2011‐ 02352772 RF‐2011‐ 02352689 Tipologia AREA STRATEGICA SCORE. Digestive, Kidney and Urological Systems The new biotechnologies 15,75 Clinical Bioengineering Sciences and Technologies The new biotechnologies 15,75 Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Oncology 15,75 NEW DIAGNOSTIC METHODS FOR Marche PERSONALIZED MEDICINE: AUTOMATIC GENERATION OF CLINICAL PATHWAY TROUGHT CORRELATION BETWEEN BIOCHEMICAL SCREENING AND STRESS IMAGING Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 15,75 Optimization of In vitro and In vivo tissue engineering of functional mammary gland and uterus for prospective translational clinical application in post‐oncologic reconstructive surgery. Biomedical Bioengineering Sciences and Technologies The new biotechnologies 15,75 Veneto Biomedical Classificazione 1 Liv. Pagina 106 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02348668 Innovative approaches for the treatment of Pompe disease: identification of potential therapeutic targets in patients with the common splicing mutation c.‐32‐13T>G and pharmacological chaperoning of alpha glucosidase. Friuli‐Venezia Giulia Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 15,75 RF‐2011‐ 02350348 Acoustic Spectroscopy of Lung Toscana Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 15,75 RF‐2011‐ 02347756 Retinal vascular imaging and risk of target organ damage among patients with suspected hypertension in primary care Piemonte Clinical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease 15,75 RF‐2011‐ 02351459 INTEGRATION OF GENOMIC MEDICINE: THE USE OF ADPKD AS A MODEL Emilia‐Romagna Biomedical Genes, Genomes and Genetics The new biotechnologies 15,75 RF‐2011‐ 02351024 Genetic polymorphisms and noninvasive scores for screening patients with progressive nonalcoholicfatty liver disease (NAFLD): an international multicenter collaborative study Piemonte Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 15,75 RF‐2011‐ 02348911 Microbiome assessment in the myocardial tissue of patients with dilated cardiomyopathy and myocarditis negative to the known cardiotropic viruses. SPALLANZANI Biomedical Infectious Diseases and Microbiology Infection and immunity 16 RF‐2011‐ 02348410 Using structural and functional MRI to assess the effects of motor rehabilitation on brain plasticity in multiple sclerosis: a double‐blind, randomized, controlled study DON GNOCCHI Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 16 AREA STRATEGICA SCORE. Pagina 107 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349546 Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in mantle cell lymphoma (MCL) treated with R‐HDS Lombardia Biomedical Oncology 2 ‐ Translational Clinical Oncology 16 RF‐2011‐ 02348888 Oncolytic Properties of Influenza A Viruses in Human Pancreatic Tumour Cells and Xenograft Models IZS Venezie Biomedical Oncology 2 ‐ Translational Clinical Oncology 16 RF‐2011‐ 02347708 Host genetic factors and response to dendritic cells based immune treatment in HIV‐1 infected patients BURLO GAROFALO AIDS and Related Research Infection and immunity 16 RF‐2011‐ 02348608 Safe production of 99mTc with a biomedical cyclotron Emilia‐Romagna Biomedical Bioengineering Sciences and Technologies The new biotechnologies 16 RF‐2011‐ 02349307 Study of the molecular mechanisms underlying the susceptibility to neonatal group B streptococcal disease SAN MATTEO Biomedical Immunology Infection and immunity 16 RF‐2011‐ 02348052 Brain proteoglycans as disease prediction genes and therapeutic targets in Multiple Sclerosis. Puglia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 16 RF‐2011‐ 02348110 Identification of novel biomolecular targets SAN RAFFAELE Pisana‐ of pets spontaneous carcinomas for the Roma development of new diagnostic and therapeutics approaches: use of the human knowledge to accelerate the management of pets tumors. Biomedical Veterinary Oncology 16 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 108 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348181 UNRAVELING THE PROTEOSTASIS NETWORK TO ADDRESS CONFORMATIONAL DISORDERS GASLINI RF‐2011‐ 02349063 Identification of new biomarkers of colorectal cancer I.E.O. RF‐2011‐ 02351559 Can we predict the degradation of cognitive status in hearing loss subjects with mild cognitive impairment based on "fluid", neurophysiological and neuroimaging markers? RF‐2011‐ 02349715 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 16 Clinical Oncology 2 ‐ Translational Clinical Oncology 16 SAN RAFFAELE Pisana‐ Roma Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 16 Preclinical and phase II clinical study of cisplatin, cetuximab and valproic acid in recurrent and/or metastatic squamous cell carcinoma of the head and neck PASCALE Clinical Oncology 2 ‐ Translational Clinical Oncology 16 RF‐2011‐ 02351708 Chemogenomics in drug discovery for regenerative therapies of common and rare myelin diseases ISS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 16 RF‐2011‐ 02348803 Pathophysiological mechanisms of fibrosis: molecular characterization in a cell based assay. CARLO BESTA Biomedical Musculoskeletal, Oral and Skin Sciences Neurological diseases 16 RF‐2011‐ 02352046 Hepatitis C virus‐host lipoproteins interplay: development of new antiviral strategies. SPALLANZANI Biomedical Infectious Diseases and Microbiology Infection and immunity 16 RF‐2011‐ 02348788 Characterization of the relationship of I.E.O. microbiota, Vitamin D, and mucins towards new colorectal cancer prevention strategies. Oncology 2 ‐ Translational Clinical Oncology 16 Clinical Pagina 109 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349658 STUDY OF CONSORTIA OF PROBIOTICS USED TO IMPROVE HUMAN HEALTH ISS RF‐2011‐ 02349040 Definition of a clinical and immunological phenotype of antibody mediated rejection in heart transplant recipients: prognostic and therapeutic implications Emilia‐Romagna RF‐2011‐ 02349785 DEVELOPMENT OF A NEW NON‐ RECOMBINANT MUCOSAL VACCINE DELIVERY SYSTEM RF‐2011‐ 02349859 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Infectious Diseases and Microbiology Food safety and animal welfare 16 Clinical Immunology Infection and immunity 16 Toscana Biomedical Immunology The new biotechnologies 16 Detection of blood‐borne EMT cells and risk of metastasis in colorectal cancer patients. HUMANITAS Biomedical Oncology 2 ‐ Translational Clinical Oncology 16 RF‐2011‐ 02351532 Birth outcomes in women with cancer: a population based cohort study IST.TUMORI MILANO Clinical Population Sciences and Epidemiology Oncology 16 RF‐2011‐ 02349861 Phenotypes in Dyslexia with genetic alteration: sensory and neuronal deficits. STELLA MARIS Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 16 RF‐2011‐ 02348670 Macrophage Senescence in Alzheimer Disease: possible link with onset and progression of the disease. I.N.R.C.A. Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 16 RF‐2011‐ 02352739 Role of nanomultilayers with anti‐ inflammatory and tracking features in human islet transplantation for the treatment of type 1 diabetes Toscana Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 16 Pagina 110 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02347626 Selective targeting of Lyn kinase and Veneto potassium channels by nocodazole and psoralen analogs in malignant cells to define innovative strategies for therapy in B‐ cell chronic lymphocytic leukemia Biomedical Oncology 2 ‐ Translational Clinical Oncology 16 RF‐2011‐ 02347574 HCV Direct Acting Antivirals (DAA) and antiretroviral drugs in pregnant women: a comprehensive surveillance/research program on maternal and neonatal safety, treatment policies, immunovirology and pharmacokinetics. ISS Biomedical Population Sciences and Epidemiology Infection and immunity 16 RF‐2011‐ 02352655 New approach for the treatment of B‐cell disorders via antiCD20 nanoparticles Friuli‐Venezia Giulia Biomedical Oncology 1 ‐ Basic Translational Oncology 16 RF‐2011‐ 02350683 Ebstein‐virus (EBV) and Human herpesvirus 6 (HHV‐6) infection in Multiple Sclerosis: a trigger for autoimmunity SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 16 RF‐2011‐ 02346842 Development of theranostic agents targeting molecular pathways involved in cell migration and metastases PASCALE Biomedical Oncology 1 ‐ Basic Translational Oncology 16 RF‐2011‐ 02347425 A pharmacological chaperone approach to rescue nucleophosmin mutants in acute myeloid leukemia Abruzzo Biomedical Biological Chemistry and Macromolecular Biophysics Oncology 16 RF‐2011‐ 02350174 Development and application of a novel Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) functional test in leukocytes Veneto Biomedical Cardiovascular and Respiratory Sciences The new biotechnologies 16 AREA STRATEGICA SCORE. Pagina 111 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352802 The role of OPG, RANK and RANKL gene SNPs (single nucleotide polymorphisms) in susceptibility to acute myocardial infarction CASA SOLLIEVO SOFFERENZA RF‐2011‐ 02350377 In situ proteomics profiling of membranous glomerulonephritis Lombardia RF‐2011‐ 02352420 Enabling bedside neurophysiological assessment and communication in functional Locked‐in syndromes after acquired brain injury SANTA LUCIA RF‐2011‐ 02347052 Biomechanical Modeling for Customized Surgical Planning in the Cartilage Treatment of the Patello‐Femoral Joint. RIZZOLI RF‐2011‐ 02352301 Overcome resistance of mTOR inhibitor in renal clear cell carcinoma targeting autophagy: a preclinical and clinical study. Lazio RF‐2011‐ 02350318 Role of Interleukins and LOX‐1 in Niemann‐ Pick Type C Disease Neurodegeneration: possible new therapeutic targets and biomarkers. ISS RF‐2011‐ 02350873 AUDIT clinico e percorsi di miglioramento nelle cure dei pazienti con infezione nelle unità di pneumologia ad alta intensità di cura (UTIR, unità di terapia intensiva respiratoria e UMR, Unità di Monitoraggio Respiratorio) della REGIONE LOMBARDIAClinical Lombardia Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 16 Digestive, Kidney and Urological Systems The new biotechnologies 16 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 16 Clinical Musculoskeletal, Oral and Skin Sciences The new biotechnologies 16 Biomedical Oncology 2 ‐ Translational Clinical Oncology 16 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 16 Infectious Diseases and Microbiology Infection and immunity 16 Biomedical Clinical Pagina 112 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02351170 NEW STRATEGY FOR DRUG DELIVERY IN PHOTODYNAMIC THERAPY OF GLIOBLASTOMA ISS Biomedical Brain Disorders and Clinical Neuroscience Oncology 16 RF‐2011‐ 02352479 PHOSPHATE HOMEOSTATIS AND PATHOGENESIS OF MINERAL AND CARDIOVASCULAR DISORDERS CASA SOLLIEVO SOFFERENZA Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 16 RF‐2011‐ 02352289 Stereo‐body radiotherapy: a novel software expert system based on the optimization of treatment schedules IRST Meldola Oncology 2 ‐ Translational Clinical Oncology 16 RF‐2011‐ 02346980 Novel biocomposite for cranial bone regeneration in pediatric patients Lazio Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 16 RF‐2011‐ 02350831 Innovative treatment of Primary Progressive Aphasias (PPA) using transcranial direct current stimulation (tDCS) combined with language training FATEBENEFRATELLI Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 16 RF‐2011‐ 02352818 Influenza vaccination of the elderly: effectiveness and determinants assessment by systematic literature review and by a historical cohort study based on 13 years of mass campaigns in Lazio and Piemonte regions Lazio Clinical Infectious Diseases and Microbiology Infection and immunity 16 RF‐2011‐ 02350469 Biological bank to identify markers of disease activity related to clinical variables and modifying drugs in multiple sclerosis Emilia‐Romagna Clinical Immunology Neurological diseases 16 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 113 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02352623 Development of new disease biomarkers by laboratory applications as diagnostic and prognostic tools for Amyotrophic Lateral Sclerosis Toscana Clinical RF‐2011‐ 02351043 The BRCAness profile: from the molecular basis to the clinical relevance Toscana RF‐2011‐ 02347559 Preclinical evaluation of isoform‐specific PI3K inhibitors' effects in IPF for novel potentialtherapies of malignat mesenchymal tumors RF‐2011‐ 02352507 Classificazione 1 Liv. AREA STRATEGICA SCORE. Brain Disorders and Clinical Neuroscience Neurological diseases 16 Biomedical Oncology 1 ‐ Basic Translational Oncology 16 Sicilia Biomedical Oncology 2 ‐ Translational Clinical Oncology 16 Inflammatory biomarkers in phenotyped COPD: relation to extrapulmonary manifestations and dysmetabolism. Toscana Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 16 RF‐2011‐ 02350960 A mirror‐neurons based stimulation protocol (MNSP) to improve language and behavior in mild to moderate people with Alzheimer Disease DON GNOCCHI Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 16 RF‐2011‐ 02352510 New methodologies for non‐invasive, quantitative and Automatic MOnitoring of childbirth LABor (AMOLAB) Puglia Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 16 RF‐2011‐ 02347275 Targeting Tenascin‐C to inhibit early lymph SAN RAFFAELE Milano node colonization by prostate cancer stem/initiating cells and immune evasion Biomedical Oncology 1 ‐ Basic Translational Oncology 16 Pagina 114 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352598 Investigation of the association between NF1 gene and NF1‐related genes transcriptional profile and high risk of tumor‐development in patients affected by Neurofibromatosis type 1. Campania RF‐2011‐ 02347032 Molecular factors predictive of heart and brain involvement in myotonic dystrophy S.CAMILLO RF‐2011‐ 02350624 The use of biomarkers in the clinical study of multiple exposure to chemicals: new diagnostic strategies to evaluate human health risk. ISS RF‐2011‐ 02349084 Circulating microRNAs as biomarkers of cardiovascular inflammatory diseases HUMANITAS RF‐2011‐ 02352617 NEW INSIGHTS FOR CAD PATIENT MANAGEMENT: in vivo assessment of coronary plaque morphology by means of OCT images and biohumoral markers (PLIMAB: PLaque IMAging Biomarkers) Toscana RF‐2011‐ 02348977 Proof of concept for a new organizational model of care delivery: the Personalized Medicine approach to the treatment of Idiopathic Environmental Intolerance Lazio RF‐2011‐ 02352607 Protocol and tools towards an investigation of low dose effects in advanced radiation therapy modalities. Piemonte Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Oncology 1 ‐ Basic Translational Oncology Clinical Musculoskeletal, Oral and Skin Sciences Neurological diseases 16,25 Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 16,25 Clinical Cardiovascular and Respiratory Sciences Infection and immunity 16,25 Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 16,25 Biomedical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 16,25 Biomedical Healthcare Delivery and Methodologies Oncology Biomedical 16 16,5 Pagina 115 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351047 GENetics of familial and sporadic Lone Atrial Fibrillation (GenLAF) SAN MATTEO RF‐2011‐ 02347249 Evaluation of the prognostic role of phosphatidylinositol 3‐kinase pathway mutations through analysis of peripheral blood and circulating tumor cells in metastatic breast cancer patients treated with endocrine therapy Toscana RF‐2011‐ 02352321 Implementing Active Surveillance for low risk prostate cancer patients: a population‐ based cohort study in the Oncological Network of Piemonte and Valle d'Aosta. The PROstate CanceR Active Surveillance sTudy (PROCRAST). Piemonte RF‐2011‐ 02350967 THE OUTCOME OF DEPRESSION AND TYPE 2 DIABETES MELLITUS WHEN THEY ARE COMORBID: A COMPARISON BETWEEN TELEMEDICINE‐ASSISTED CARE AND TREATMENT AS USUAL Veneto RF‐2011‐ 02349210 Circulating microRNAs as prognostic biomarkers of arterial remodeling/restenosis after percutaneous transluminal intervention in patients with peripheral arterial disease I.N.R.C.A. RF‐2011‐ 02351073 Serum and tissue miRs as biomarkers for diagnosis and prognosis of B‐NHL in chronically HBV or HCV‐infected patients ISS Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 16,5 Oncology 2 ‐ Translational Clinical Oncology 16,5 Clinical Healthcare Delivery and Methodologies Oncology 16,5 Clinical Biobehavioral and Behavioral Processes Neurological diseases 16,5 Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 16,5 Biomedical Oncology 2 ‐ Translational Clinical Infection and immunity 16,5 Biomedical Pagina 116 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352068 GENERATION OF RED CELLS WITH RARE OR UNCOMMON BLOOD GROUP PHENOTYPES FROM HUMAN INDUCED PLURIPOTENT STEM CELLS (hiPSCs) Lazio RF‐2011‐ 02348462 Puzzle: a multiparametric approach to clinical decision making and monitoring of children admitted to pediatric cardiac intensive care for congenital heart diseases OSPEDALE BAMBINO GESU' RF‐2011‐ 02350286 Role of autophagy core complex in tumor onset and progression SANTA LUCIA Biomedical RF‐2011‐ 02349306 Clinical markers of chilhood apraxia of speech and its neurobiological and genetic correlates STELLA MARIS Clinical RF‐2011‐ 02348187 GENETIC INVOLVEMENT OF DESMOPLAKIN AND OTHER DESMOSOMAL PROTEINS IN DILATED CARDIOMYOPATHY SAN MATTEO Biomedical RF‐2011‐ 02347369 Neurorehabilitation of post‐stroke disorders using integrated behavioral and brain stimulation tools SANTA LUCIA Clinical RF‐2011‐ 02349235 Emilia‐Romagna Dissection of the MYCN/MAX/MAD transcription factor network as a critical step to designnovel therapeutic approaches to treat pediatric neuroblastoma RF‐2011‐ 02351361 Intranasal delivery of nano‐modified drugs for the treatment of glioblastoma Toscana Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Bioengineering Sciences and Technologies The new biotechnologies 16,5 Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 16,5 Cell Biology Oncology 16,5 Brain Disorders and Clinical Neuroscience Neurological diseases 16,5 Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 16,5 Brain Disorders and Clinical Neuroscience Neurological diseases 16,5 Biomedical Oncology 1 ‐ Basic Translational Oncology 16,5 Biomedical Oncology 1 ‐ Basic Translational Oncology 16,5 Clinical Pagina 117 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02351879 Health impact assessment and health care costs of respiratory tract infections (RTIs) in general population and hospitalized patients Sicilia RF‐2011‐ 02351929 High throughput, population‐wide, reflex testing of GI cancer: biologic characterization, identification of individualized therapy targets and prevention of familial cases AOU San Martino‐IST ‐ Genova Clinical RF‐2011‐ 02348159 Role of tumor microenvironment in thyroid carcinogenesis onset and progression: thyroid cells cross‐talk with macrophages IST.TUMORI MILANO RF‐2011‐ 02347360 Identification and characterization of genes involved in progenitor cells reprogramming into stem cells and cancer stem cells, as novel cancer therapeutic targets. RF‐2011‐ 02348584 Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Population Sciences and Epidemiology Infection and immunity 16,5 Oncology 2 ‐ Translational Clinical Oncology 16,5 Biomedical Oncology 1 ‐ Basic Translational Oncology 16,5 I.E.O. Biomedical Oncology 1 ‐ Basic Translational Oncology 16,5 Unraveling the role of sodium channels in the susceptibility to neuropathic pain CARLO BESTA Biomedical Genes, Genomes and Genetics Neurological diseases 16,5 RF‐2011‐ 02350620 A diagnostic innovative software for surgical planning in hip arthroplasty for patients with hip dysplasia to optimize functional recovery. RIZZOLI Clinical Bioengineering Sciences and Technologies The new biotechnologies 16,5 RF‐2011‐ 02349919 OSPEDALE BAMBINO DEVELOPMENT OF A NEW ARTIFICIAL HEART FOR PEDIATRIC PATIENTS WITH GESU' Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 16,5 END‐STAGE HEART FAILURE Pagina 118 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02350232 Ankrd2 as a novel repressor of immune and inflammatory responses through regulation of myokine expression. RF‐2011‐ 02350428 DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Musculoskeletal, Oral and Skin Sciences Infection and immunity 16,5 Molecular modeling of advanced/metastatic RIZZOLI soft tissue sarcomas to develop evidence‐ based therapeutic targets and circulatory biomarkers Biomedical Oncology 2 ‐ Translational Clinical Oncology 16,5 RF‐2011‐ 02346852 The extracellular matrix EMILIN2 as a key molecule regulating colon carcinogenesis and as a potential prognostic marker. C.R.O. AVIANO Biomedical Oncology 1 ‐ Basic Translational Oncology 16,5 RF‐2011‐ 02347639 Integrated analysis of somatic mutations and related altered pathways for the identification of new biomarkers and molecular targets in tumors of the lower female genital tract. PASCALE Clinical Oncology 1 ‐ Basic Translational Oncology 16,5 RF‐2011‐ 02351253 Early Retinal Neuroprotection as a Novel Tool to Achieve the Primary Prevention of Diabetic Retinopathy SAN RAFFAELE Milano Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 16,5 RF‐2011‐ 02352296 Risk of metachronous cancer in genetically predisposed colorectal patients IST.TUMORI MILANO Clinical Oncology 2 ‐ Translational Clinical Oncology 16,5 RF‐2011‐ 02351652 Diagnostic, prognostic, and monitoring SDN markers based on muscular, neurophysiological and neuroimaging markers in dystonic patients. A pilot clinical study Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 16,5 HUMANITAS Pagina 119 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347786 A network of external quality controls for the molecular diagnosis of sporadic and hereditary cancers Emilia‐Romagna RF‐2011‐ 02351419 TrkAIII expression in Glioblastoma: Significance in prognosis, relationship to therapeutic response and role in pathogenesis and progression. Abruzzo Biomedical RF‐2011‐ 02348249 New minimally invasive arthroscopical approach for the treatment and prevention of hip osteoarthritis RIZZOLI Clinical RF‐2011‐ 02351409 Spatially variant prescription of dose radiation from hypoxic tumor distribution assessed by VEGF expression and biological imaging: a phases I‐II study in non small cell lung cancer CROB RF‐2011‐ 02349955 Heart‐liver axis in metabolic syndrome: common damage mechanisms as an input for patient management OSPEDALE BAMBINO GESU' RF‐2011‐ 02346762 Evaluation of patient preferences around the different cancer services dimensions: new evidences for improving service organisation. Piemonte Clinical RF‐2011‐ 02347730 Modulating the inflammation of cerebral death to improve the survival of graft Campania Biomedical Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Healthcare Delivery and Methodologies Oncology 16,5 Oncology 2 ‐ Translational Clinical Oncology 16,5 Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 16,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 16,5 Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 16,5 Healthcare Delivery and Methodologies Oncology 16,5 Surgical Sciences, Biomedical Imaging, and Bioengineering Infection and immunity 16,5 Pagina 120 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348922 SILK BASED BASEMENT MEMBRANE MODEL: A NEW TOOL FOR THE STUDY OF PLATELET PRODUCTION, FUNCTIONALITY AND THERAPEUTIC APPROACHES RF‐2011‐ 02350019 Natural history of Myotonic Dystrophy type SANTA LUCIA 1. Epidemiology in the Lazio region, clinical protocol standardization, and assessment of clinical and molecular endpoints in a longitudinal cohort study. RF‐2011‐ 02348817 Prospective multicenter study on antibiotic prophylaxis protocol (ABP) for the prevention of Neurosurgical Surgical Site Infection (N‐SSIs), with taylored strategies for High Risk (HR) classes RF‐2011‐ 02351278 AFTEREIGHT study: anticipated boost with I.E.O. intraoperative electrons (IORT) followed by short‐course hypofractionated whole breast radiotherapy in early breast cancer patients. RF‐2011‐ 02347027 THE ROLE OF CALCIUM HOMEOSTASIS IN CONGENITAL CEREBELLAR ATAXIAS : genetic dissection and functional characterization of a neuronal specific plasma membrane Ca2+ATPase OSPEDALE BAMBINO GESU' RF‐2011‐ 02349652 HIV INFECTION AND ANTIRETROVIRAL TREATMENT: EFFECTS ON BONE‐ MARROW HEMATOPOIETIC STEM CELLS SPALLANZANI SAN MATTEO CARLO BESTA Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Bioengineering Sciences and Technologies The new biotechnologies 16,5 Clinical Population Sciences and Epidemiology Neurological diseases 16,5 Clinical Infectious Diseases and Microbiology Infection and immunity 16,5 Clinical Healthcare Delivery and Methodologies Oncology 16,5 Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 16,5 Biomedical AIDS and Related Research Infection and immunity 16,5 Pagina 121 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02350658 Translational approach to the cardiovascular effects of antipsychotics Piemonte Biomedical Emerging Technologies and Training in Neurosciences Metabolism disorders and cardiovascular disease 16,5 RF‐2011‐ 02349483 Development of an antimicrobial food packaging by using essential oils and nanotechnology ‐ EssencePack IZS Mezzogiorno Biomedical Veterinary Food safety and animal welfare 16,5 RF‐2011‐ 02349130 Vagal nerve stimulation as a novel strategy AUXOLOGICO to limit post‐ischemic injury and possibly to prevent the development of ischemic cardiomyopathy Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 16,5 RF‐2011‐ 02350156 Mother‐to‐infant transmission of infectious diseases: development of clinical pathways for an appropriate/comprehensive care of pregnant women with infections and their infants. OSPEDALE BAMBINO GESU' Clinical Infectious Diseases and Microbiology Infection and immunity 16,5 RF‐2011‐ 02349119 Innovative biological markers in type 1 diabetes SAN RAFFAELE Milano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 16,5 RF‐2011‐ 02349484 WNV endemization in Italy: implications for the national transplant program SPALLANZANI Biomedical Infectious Diseases and Microbiology Infection and immunity 16,5 RF‐2011‐ 02352756 Comparative effectiveness: Hospital volumes and outcomes of treatments. Systematic reviews and observational study in Italian NHS. AGENAS Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 16,5 RF‐2011‐ 02350715 Aging‐related platelet transcriptome variations in atherothrombosis Umbria Biology of Development and Aging Metabolism disorders and cardiovascular disease 16,5 Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 122 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350422 Effects of a controlled exercise intervention in modulating endothelial dysfunction and related humoral markers in coronary patients with type 2 diabetes DON GNOCCHI RF‐2011‐ 02351274 Imaging pREdictors of outcome after Surgical myOcardiaL revascUlarizaTION [RESOLUTION trial] Lazio RF‐2011‐ 02347273 New molecular markers of pathogenetic and translational significance in tumoral and peritumoral tissue of primary liver cancer RF‐2011‐ 02349733 OVERWEIGHT/OBESITY/SEVERE OBESITY: TIME TRENDS AND LONGTERM BENEFITS OF WEIGHT REDUCTION RF‐2011‐ 02352410 A tool to diagnose the impairment of SANTA LUCIA aphasic patients and direct rehabilitation by analysing speech errors RF‐2011‐ 02350588 Integrated approach to investigate the effect of environmental pollution on reproductive outcomes RF‐2011‐ 02351556 In vivo model for tissue engineering of urethral reconstruction on bio‐absorbable scaffold or recellularized matrixes Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 16,5 Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 16,5 HUMANITAS Biomedical Oncology 1 ‐ Basic Translational Oncology 16,75 ISS Biomedical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease 16,75 Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 16,75 Emilia‐Romagna Biomedical Genes, Genomes and Genetics Diseases of environmental origin, with reference also to the workplace 16,75 Sicilia Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 16,75 Pagina 123 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349547 Early integration of palliative care with standard oncologic care in advanced non‐ small cell lung cancer. A prospective,multi‐ center observational study to evaluate how this approach impact on patients survival and quality of life with an additional anal Veneto Clinical Healthcare Delivery and Methodologies Oncology 16,75 RF‐2011‐ 02349435 Fostering donation: from bench to culture MAGGIORE Clinical Healthcare Delivery and Methodologies Neurological diseases 16,75 RF‐2011‐ 02347696 HUMAN ADIPOSE STEM CELLS AS A NOVEL TARGET FOR THERAPEUTIC INTERVENTION IN OBESITY Toscana Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 16,75 RF‐2011‐ 02349433 Innovative aspects in the study of acute Campania hepatitis C, in the laboratory diagnosis and study of clinica, genetic, virological and biomolecular prognostic markers and in the optimization of therapeutic protocols Biomedical Infectious Diseases and Microbiology Infection and immunity 17 RF‐2011‐ 02348328 MICRORNA IN THYROID CARCINOMA: PATHWAYS INVOLVED AND POSSIBLE PROGNOSTIC AND THERAPEUTIC IMPACT Biomedical Oncology 1 ‐ Basic Translational Oncology 17 RF‐2011‐ 02351427 A CLINICAL AND MORPHOLOGICAL Toscana INVESTIGATION OF BOTULINUM TOXIN‐ A TREATMENT FOR NEUROGENIC DETRUSOR OVERACTIVITY: OUTCOMES, CORRELATION BETWEEN URODYNAMIC PATTERN AND EXPRESSION OF UROTHELIUM AND SUBUROTHELIUM ION CHANNELS AND NEUROKININ RECEPTORS IN SPINA Biomedical Digestive, Kidney and Urological Systems Neurological diseases 17 IST.TUMORI MILANO Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 124 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349218 Standardization of a SNP‐typing protocol IZS Puglia e della Basilicata Biomedical for epidemiology of Listeria monocytogenes and study of the molecular evolution of an emerging Epidemic Clone. RF‐2011‐ 02348701 Epidemiological, clinical and molecular IDI aspects of Environmental Intolerance Disorders with Difficult Diagnosis in the Italian population, with special focus on the sick worker. Implications for Disease Definition, Diagnosis and Treatment, and Workplace S RF‐2011‐ 02352873 PERFUSION COMPUTED TOMOGRAPHY (PCT) AND VASCULAR ENDOTHELIAL GROWTH FACTOR‐A (VEGF‐A) SERUM AND LIQUOR LEVELS IN THE MANAGEMENT OF HIGH GRADE GLIOMAS NEUROMED RF‐2011‐ 02351734 Instrumental and clinical validation of a new diagnostic‐therapeutic approach to the dysfunction of movement for rehabilitation in non‐specific low back pain RF‐2011‐ 02350855 RF‐2011‐ 02351666 Classificazione 1 Liv. AREA STRATEGICA SCORE. Infectious Diseases and Microbiology Food safety and animal welfare 17 Immunology Diseases of environmental origin, with reference also to the workplace 17 Clinical Emerging Technologies and Training in Neurosciences Oncology 17 Emilia‐Romagna Clinical Bioengineering Sciences and Technologies Diseases of environmental origin, with reference also to the workplace 17 Development and validation of software tools to use radiation dose data extracted from digital medical images for radiation protection purposes I. O. V. Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering Oncology 17 Sleep disorders in neuromuscular diseases: a comprehensive clinical and polisomnographyc study regarding myotonic dystrophies type 1 and type 2 and spinal bulbar muscular atrophy (SBMA). Lazio Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 17 Biomedical Pagina 125 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02351663 Clinical Impact of Image guided hypofractionated intensity modulated radiotherapy in the treatment of prostate, lung and head and neck cancers Emilia‐Romagna Clinical Oncology 2 ‐ Translational Clinical Oncology 17 RF‐2011‐ 02352825 Definition of a "Myeloma Panel" to analyze the role played by clonal evolution in the resistance to therapy Emilia‐Romagna Clinical Oncology 2 ‐ Translational Clinical Oncology 17 RF‐2011‐ 02346802 A translational integrated study on prostate diseases and environmental risk factors in Sicily for primary and secondary prevention (acronym: PROSTENV) ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diseases of environmental origin, with reference also to the workplace 17 RF‐2011‐ 02352776 Risk assessment of developing atypical MAGGIORE Hemolitic Uremic Syndrome by genetic and epigenetic investigations Biomedical Genes, Genomes and Genetics Infection and immunity 17 RF‐2011‐ 02349077 IDENTIFICATION OF NEW DRUGGABLE PATHWAYS FOR PERSONALIZED TREATMENTS IN INTRAHEPATIC CHOLANGIOCARCINOMA Piemonte Biomedical Oncology 2 ‐ Translational Clinical Oncology 17 RF‐2011‐ 02350723 Preclinical Development of Novel Small Androgen Receptor Modulating Molecules (SARMs) in Experimental Human Prostate Cancer Model. IRST Meldola Biomedical Oncology 2 ‐ Translational Clinical Oncology 17 RF‐2011‐ 02349224 Role of Vitamin D receptor in angiogenic and DNA damage repair pathways with respect to BRCA1 status ONCOLOGICO DI BARI Biomedical Oncology 2 ‐ Translational Clinical Oncology 17 AREA STRATEGICA SCORE. Pagina 126 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02352728 Internet Addiction in adolescents: identification of possible neurobiological and personality markers. Toscana Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 17 RF‐2011‐ 02350996 Perturbed hydrogen sulphide content in Amyotrophic Lateral Sclerosis: a possible player in motor neurons degeneration? SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 17 Oncology 2 ‐ Translational Clinical Oncology 17 RF‐2011‐ 02350641 DESTINATARIO ISTITUZIONALE Sicilia Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Assessment of Predictive Biomarkers of Outcome and Treatment Response in Primary Tumor and in Circulating Tumor Cells of Non‐Small Cell Lung Cancer Patients by Organization of a Clinical and Molecular Network in Sicily RF‐2011‐ 02349202 The molecular basis of the interplay between leukotriene and purinergic systems: new therapies in vascular inflammation Lombardia Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 17 RF‐2011‐ 02350468 Causes, diagnosis and treatment of unexplained neurobehavioral disorders: role of thyroid hormone cell membrane transporters and environmental contaminants. Toscana Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 17 RF‐2011‐ 02348614 Innovative preclinical platforms for the personalized treatment in ovarian cancer Piemonte Biomedical Oncology 2 ‐ Translational Clinical Oncology 17 Pagina 127 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352657 Multi‐Step versus Single‐Step strategy of Transjugular Intrahepatic Portosystemic Shunt (TIPS) Endoprosthesis Placement for Prevention of Post‐TIPS Hepatic Encephalopathy in Cirrhotic Patients with Refractory Ascites. Emilia‐Romagna RF‐2011‐ 02348599 Traditional and innovative monitoring of dioxins and dioxin like‐compounds in exposed sheep: chemical and biomolecular approaches in a sentinel species. IZS Piemonte, Liguria e Valle d'Aosta RF‐2011‐ 02349272 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Digestive, Kidney and Urological Systems Neurological diseases 17 Biomedical Veterinary Food safety and animal welfare 17 DEVELOPMENT OF 3D IN VITRO TUMOUR/MSC COCULTURE MODEL AND IN VIVO IMAGING LUMINESCENT PROTOCOL TO REFINE AND REDUCE THE USE OF ANIMAL IN ONCOLOGICAL STUDIES. (DIANA) IZS Lombardia e dell'Emilia Biomedical Veterinary Food safety and animal welfare 17 RF‐2011‐ 02351467 Facioscapulohumeral muscular dystrophy: to define non‐invasive outcome measures and elucidate molecular mechanisms underlying muscle degeneration by means of longitudinal muscle MRI studies, immunological assessment and biomolecular characterization of a MONDINO Biomedical Musculoskeletal, Oral and Skin Sciences Neurological diseases 17 RF‐2011‐ 02349333 LAV‐ BPIFB4 isoform, a new target to fight endothelial dysfunction MULTIMEDICA Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 17 RF‐2011‐ 02352602 Early Neurorehabilitation in Neurosubintensive Care Unit Lombardia Brain Disorders and Clinical Neuroscience Neurological diseases 17 Clinical Pagina 128 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02348461 Development of novel chemo‐ immunotherapy strategy for hepatocellular carcinoma PASCALE Biomedical Oncology 2 ‐ Translational Clinical Oncology 17 RF‐2011‐ 02348746 Nanoparticles engineered with antibody derivatives or other molecules recognizing markers overexpressed in breast cancer cells for metastatic tumor detection Lombardia Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering Oncology 17 RF‐2011‐ 02350290 Impact of intensive follow up on diagnostic anticipation in high risk stage I‐III breast cancer patients. A phase II, multicenter randomized study. AOU San Martino‐IST ‐ Genova Oncology 2 ‐ Translational Clinical Oncology 17 RF‐2011‐ 02349827 From bench to bedside in deciphering the modulatory mechanisms of the molecular damage in hereditary spastic paraplegias MEDEA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 17 RF‐2011‐ 02348109 Developing an event‐based computational model of Alzheimer's disease progression incorporating quantitative MRI and TMS information to assist clinicians in the early diagnosis, correct prognosis, and treatment monitoring. SANTA LUCIA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 17 RF‐2011‐ 02351305 Compound Seropositivity of neutralizing Sicilia antibodies against Adipogenic Adenoviruses (ADV36+ and ADV 37+): effect of nutritional intervention on overweight‐ obesity, Non‐Alcoholic‐Fatty‐Liver‐Disease (NAFLD) and on Insulin Resistance. Digestive, Kidney and Urological Systems Infection and immunity 17 Clinical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 129 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352074 Estimate of Late diagnosis and Late presentation of HCV infection in high‐risk and hard to reach population. SPALLANZANI RF‐2011‐ 02347467 The Rac1‐activator CNF1 as a therapeutic approach for amyotrophic lateral sclerosis ISS RF‐2011‐ 02347859 Isolated Hemihyperplasia (IH), a pediatric cancer risk disease: search for novel genes and mechanisms AUXOLOGICO RF‐2011‐ 02347589 Apoptotic and DNA damage/repair Lazio mechanisms induced by anti‐neoplastic agents in mammalian oocytes of the ovarian reserve and strategies for fertility preservation in female patients. RF‐2011‐ 02352327 Monitoring infection in complex wounds in pediatric patients OSPEDALE BAMBINO GESU' RF‐2011‐ 02349690 EXOSOME‐MEDIATED CONTROL OF HEMATO‐ENDOTHELIAL CELL DIFFERENTIATION ISS RF‐2011‐ 02351157 ROLE OF DORSOLATERAL PREFRONTAL CORTEX IN LONG TERM RECOGNITION MEMORY: TRANSCRANIAL MAGNETIC STIMULATION APPROACHES FOR TREATMENT OF LONG TERM MEMORY DEFICITS IN AMNESIC PATIENTS SANTA LUCIA RF‐2011‐ 02350125 Identifcation of the genetic landscape of T‐ cell lymphoblastic lymphoma of childhood Veneto Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Infectious Diseases and Microbiology Infection and immunity 17 Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 17 Biomedical Genes, Genomes and Genetics The new biotechnologies 17 Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Oncology 17 Healthcare Delivery and Methodologies Infection and immunity 17 Cell Biology Oncology 17 Brain Disorders and Clinical Neuroscience Neurological diseases 17 Oncology 1 ‐ Basic Translational Oncology 17 Clinical Biomedical Clinical Biomedical Pagina 130 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348221 STRUCTURED PATHOLOGICAL REPORT IN ONCOLOGY.A DIGITAL NETWORK AMONG PATHOLOGY UNITS, TUMOR REGISTRIES AND REGIONAL HEALTH CARE SYSTEM. Emilia‐Romagna RF‐2011‐ 02349872 CDKL5 DISORDER: identification of the molecular mechanisms underlying the neurological phenotype Ist.Sci. Neurologiche Bologna RF‐2011‐ 02349730 New molecular predictive markers in Colorectal Cancer (CRC) RF‐2011‐ 02347597 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Healthcare Delivery and Methodologies Oncology 17 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 17 Sicilia Biomedical Genes, Genomes and Genetics Oncology 17 Exploiting the diagnostic, prognostic and therapeutic potential of microRNAs in melanoma IDI Biomedical Oncology 2 ‐ Translational Clinical Oncology 17 RF‐2011‐ 02351405 BIOSAFETY OF HUMAN MESENCHYMAL STEM CELLS: GENOMIC AND MEMBRANE STABILITY FOR A BETTER CLINICAL APPROACH Piemonte Biomedical Genes, Genomes and Genetics The new biotechnologies 17 RF‐2011‐ 02351065 Development of guidelines for the Toscana management of cluster of cancer and other diseases in areas with environmental criticalities and translation for public health decision‐makers. Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 17 RF‐2011‐ 02350056 Artificial Neural Network in development of MONZINO Innovative Diagnostic systems for Atherosclerotic disease (The ANN‐IDA project) Surgical Sciences, Biomedical Imaging, and Bioengineering Metabolism disorders and cardiovascular disease 17 Clinical Biomedical Pagina 131 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349548 Atherogen Genetic Dyslipidemias (AGD): are they missed diseases?Estimate of frequency of AGD diagnoses in the Tuscany hospitals and strategy design to identify probands with AGD and trigger early diagnosis in family members Toscana RF‐2011‐ 02348081 Genetic and pharmacological inhibitors of the Epithelial‐Mesenchymal Transition REGINA ELENA RF‐2011‐ 02347950 Role of adipose derived stem cells in chondrocyte functional impairment in metabolic osteoarthritis RF‐2011‐ 02347580 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 17 Biomedical Oncology 1 ‐ Basic Translational Oncology 17 RIZZOLI Biomedical Musculoskeletal, Oral and Skin Sciences Metabolism disorders and cardiovascular disease 17 A new therapeutic approach against HPV cancer based on anti‐E6 and ‐E7 scFv antibodies: validation in preclinical models and studies on the molecular mechanisms ISS Biomedical Oncology 2 ‐ Translational Clinical The new biotechnologies 17 RF‐2011‐ 02350289 Metabolic tumour volume as assessed by 18F‐FDG PET/CT for tailoring therapy in patients with locally advanced rectal cancer candidate for neoadjuvant chemoradiation. Liguria Clinical Oncology 2 ‐ Translational Clinical Oncology 17 RF‐2011‐ 02351026 Chemotherapies of stem‐cells‐based solid vascularized tumors: from the bench to the bedside passing through equations I.E.O. Biomedical Bioengineering Sciences and Technologies Oncology 17,25 RF‐2011‐ 02350009 Effect of lower limb end‐effector robot‐ assisted therapy with Virtual Realty on gait training in Parkinson Patients. SAN RAFFAELE Pisana‐ Roma Clinical Biobehavioral and Behavioral Processes Neurological diseases 17,25 Pagina 132 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02351820 Forced Robotic Exercise Training effects on motor and cognitive functions of Parkinson's Disease patients Toscana Biomedical Emerging Technologies and Training in Neurosciences Neurological diseases 17,25 RF‐2011‐ 02350955 Neurocognitive deficits related to cardiosurgery intervention with extracorporeal circulation. Correlations between neuropsychological performances and functional MRI techniques (Spectroscopy, Diffusion and Morphometry) Toscana Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 17,5 RF‐2011‐ 02349353 Postactivation depression in hemiplegic stroke survivors: implications for assessment and treatment of spasticity AOU San Martino‐IST ‐ Genova Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 17,5 RF‐2011‐ 02348790 Culture and characterization of oral mucosal and conjunctival epithelial stem cells for the reconstruction of the ocular surface in patients with bilateral limbal stem cell deficiency Veneto Biomedical Brain Disorders and Clinical Neuroscience The new biotechnologies 17,5 RF‐2011‐ 02350884 RESPIRATORY TRAINING IN HEART MAUGERI FAILURE: A NON‐INVASIVE METHOD TO INCREASE THE CHOLINERGIC ANTI‐ INFLAMMATORY PATHWAY Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 17,5 RF‐2011‐ 02351872 Evaluation of in vitro drug‐sensitivity and phosphoproteomic expression profiles in patients diagnosed with renal carcinoma REGINA ELENA Digestive, Kidney and Urological Systems Oncology 17,5 RF‐2011‐ 02349256 Nanomaterials and Health: a multilevel approach to study the effects of nanomaterials at workplaces INAIL Bioengineering Sciences and Technologies Diseases of environmental origin, with reference also to the workplace 17,5 Clinical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 133 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02349479 Identification of biological and immune PASCALE correlates of therapeutic responses for HPV‐ positive epithelial cancers: an ex vivo organotypic multi‐cellular model for patient‐tailored therapies. Biomedical Oncology 1 ‐ Basic Translational Oncology 17,5 RF‐2011‐ 02352224 Signals from deregulated skin metabolism control generalized metabolic syndrome in psoriasis IDI Biomedical Musculoskeletal, Oral and Skin Sciences Metabolism disorders and cardiovascular disease 17,5 RF‐2011‐ 02350703 In vitro assessment of lactic acid bacteria ISS for suitability as probiotics in calves to improve health in newborns and to contrast neonatal mortality Biomedical Veterinary Food safety and animal welfare 17,5 RF‐2011‐ 02349790 Role of DNA‐PK in neurodegeneration and aging: enhancement of DNA repair as novel therapeutic approach ISS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 17,5 RF‐2011‐ 02349213 Genomics of treatment response in acute myeloid leukemia I.E.O. Biomedical Oncology 2 ‐ Translational Clinical Oncology 17,5 RF‐2011‐ 02350704 IS IT TIME TO SELECT PATIENTS WITH MALIGNANT PLEURAL MESOTHELIOMA (MPM) WHO MIGHT BENEFIT FROM AGGRESSIVE TREATMENT AND PROSPECTIVELY ANALYZE ONCOLOGIC AND FUNCTIONAL RESULTS? AOU San Martino‐IST ‐ Genova Clinical Oncology 2 ‐ Translational Clinical Oncology 17,5 RF‐2011‐ 02349843 SEPSIS TEAM: A MODEL OF INNOVATIVE Emilia‐Romagna MANAGEMENT OF THE PATIENT REFERRED TO EMERGENCY DEPARTMENT WITH A CONDITION OF SEVERE SEPSIS/SEPTIC SHOCK Clinical Infectious Diseases and Microbiology Infection and immunity 17,5 AREA STRATEGICA SCORE. Pagina 134 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351784 Endogenous obesogens accumulation and AUXOLOGICO adipose tissue dysfunction: identification of toxogenomic, metabolomic and epigenetic signatures in adipocytes as a tool to understand environmental causes of human obesity RF‐2011‐ 02346995 Radiation exposure optimization by wireless technology for professionals involved in the management and care of patients undergoing therapy with radionuclides. Implementation of environmental monitoring. CROB RF‐2011‐ 02351612 Molecular basis of Treatment‐Resistant Depression FATEBENEFRATELLI RF‐2011‐ 02352098 Molecular events underlying the metastatic potential of cancer stem cells RF‐2011‐ 02351127 RF‐2011‐ 02349188 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 17,5 Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 17,5 Biomedical Biobehavioral and Behavioral Processes Neurological diseases 17,5 Sicilia Biomedical Oncology 2 ‐ Translational Clinical Oncology 17,5 IDENTIFICATION OF NEW STRATEGIES TO IMPROVE THE OUTCOME OF TRAUMATIC BRAIN INJURY AND BRAIN ISCHEMIA: PRECLINICAL AND CLINICAL STUDIES ON NEW TARGETS AND ALREADY CLINICALLY AVAILABLE DRUGS Sicilia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 17,5 Evaluation of the olfactory function in the endoscopic trans‐nasal neurosurgical cancer patients: advanced medical technology and methodology Ist.Sci. Neurologiche Bologna Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 17,5 Clinical Pagina 135 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02352209 Morphological and molecular phenotype of lung cancer in chronic obstructive pulmonary disease Veneto Biomedical Oncology 2 ‐ Translational Clinical Oncology 17,5 RF‐2011‐ 02347140 Pathogenesis, diagnosis and course of familial and sporadic Alzheimer¿s disease and Frontotemporal Lobar degeneration: epigenetics and proteomics as new tools for disease mechanisms and biomarker discovery MAGGIORE Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 17,5 RF‐2011‐ 02348036 Identification of genetic variants associated with appropriate ICD therapy Provincia autonoma Bolzano Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 17,5 RF‐2011‐ 02347676 Novel PHOX2B defects and additional genes involved in the onset of Respiratory and Autonomic Disorders in Infancy, Childhood and Adulthood (RADICA): definition of pathogenic mechanisms and search for ameliorative drugs GASLINI Biomedical Genes, Genomes and Genetics Neurological diseases 17,5 RF‐2011‐ 02351936 Determination of the dose distribution in patients treated with high energy photon beams using transmitted dose planar distributions measured with a new gas detector technology (Gas Electron Multipliers) and a dedicated back‐ projection algorithm. REGINA ELENA Biomedical Oncology 2 ‐ Translational Clinical Oncology 17,5 RF‐2011‐ 02351051 Neonatal development, neuro‐endocrine programming and mother‐child exposure to pesticides: a translational prevention study (NATAL) ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diseases of environmental origin, with reference also to the workplace 17,5 AREA STRATEGICA SCORE. Pagina 136 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350387 Role of microRNAs in esophageal carcinogenesis and the possible correlation between microRNA serum levels and different stages of esophageal disease Sicilia RF‐2011‐ 02347670 Active music therapy approach in the rehabilitation of stroke: a randomized controlled trial. MAUGERI RF‐2011‐ 02352705 Study and modelling of early alterations of microcirculation insepsis aimed at personalized treatment and identification of the outcome. Toscana RF‐2011‐ 02349636 Characterization of specific factors that prevent HIV‐1‐induced cell death in Long Term Non Progressors and Elite Controllers. From pathogenesis to new treatments. SPALLANZANI RF‐2011‐ 02350773 Immunologic, autonomic and metabolic components of exercise medicine in cancer survivors HUMANITAS RF‐2011‐ 02348231 Respiratory Syncytial Virus (RSV) infection ISS in infants: the IFNs/ Ectonet axis as possible therapeutic target. RF‐2011‐ 02352554 Melanoma: from next generation sequencing to personalized targeted therapy SAN GALLICANO Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 1 ‐ Basic Translational Oncology 17,5 Clinical Healthcare Delivery and Methodologies Neurological diseases 17,5 Clinical Infectious Diseases and Microbiology Infection and immunity 17,5 AIDS and Related Research Infection and immunity 17,5 Risk, Prevention and Health Behavior Oncology 17,5 Immunology Infection and immunity 17,5 Healthcare Delivery and Methodologies Oncology 17,5 Biomedical Clinical Biomedical Clinical Pagina 137 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349148 Age‐related evaluation of the usefulness of implantable cardiac defibrillator with or without cardiac resynchronization therapy: a real‐world analysis in patients with severe chronic heart failure Toscana RF‐2011‐ 02347299 Pathophysiology of obesity‐related vascular dysfunction: comparison between "metabolically healthy obesity" and the metabolic syndrome Lazio RF‐2011‐ 02352508 Circulating biomarkers as predictive and prognostic factors in patients with stage III melanoma: analysis of circulating melanoma cells (CMCs), circulating free‐ DNA (cfDNA) and molecular characterization of BRAF and NRAS mutational status in primary tumor Lombardia RF‐2011‐ 02350812 Single‐dose intravenous iron in patients with functional iron deficiency after acute myocardial infarction: impact on hospital‐ acquired anemia, cardiovascular and functional status AUXOLOGICO RF‐2011‐ 02350075 A wait and see approach to identify predictors of aggressiveness in sporadic desmoid tumor IST.TUMORI MILANO RF‐2011‐ 02351044 Origin and significance of residual viremia in virologically suppressed HIV‐infected patients. SPALLANZANI Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 17,5 Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 17,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 17,5 Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 17,5 Clinical Oncology 2 ‐ Translational Clinical Oncology 17,5 AIDS and Related Research Infection and immunity 17,5 Biomedical Pagina 138 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02348267 Unraveling the molecular basis of neurodegeneration in frontotemporal lobar degeneration: role of genome instability associated with tau mutations CARLO BESTA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 17,5 RF‐2011‐ 02347320 PROTEASE VARIABILITY IN PATIENTS INFECTED WITH HEPATITIS C VIRUS GENOTYPE 1: IMPLICATIONFOR ANTIVIRAL TREATMENT USING DIRECTLY ACTING ANTIVIRALS (DAA) Sicilia Biomedical Infectious Diseases and Microbiology Infection and immunity 17,5 RF‐2011‐ 02351905 Evaluation of the pathogenetic role of Parvovirus B19V in systemic sclerosis and autoimmune thyroiditis. Toscana Immunology Infection and immunity 17,5 RF‐2011‐ 02351461 Evaluation of the activity of HIV protease or ISS reverse transcriptase inhibitors against experimental models of uterine cervical tumours Biomedical Oncology 2 ‐ Translational Clinical Oncology 17,5 RF‐2011‐ 02352604 Investigating the relationship between IZS Venezie animal farming and antibiotic resistances in natural or environmental prokaryotic communities Biomedical Veterinary Food safety and animal welfare 17,5 RF‐2011‐ 02349701 CDKs blockade for molecular targeting in human cancer. C.R.O. AVIANO Biomedical Oncology 1 ‐ Basic Translational Oncology 17,5 RF‐2011‐ 02352438 ANALYSIS OF THE GENETIC AND EPIGENETIC BASIS OF HCV‐RELATED LYMPHOPROLIFERATIVE DISORDERS Toscana Biomedical Infectious Diseases and Microbiology Oncology 17,5 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 139 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351320 Determinants of functional recovery in elderly hip fracture subjects admitted to orthogeriatric units: a multicentre observational study ARCISPEDALE‐Reggio Emilia RF‐2011‐ 02351367 MicroRNA: new markers for the diagnosis of occult hepatitis B ISS RF‐2011‐ 02348167 NAFLD (Non‐Alcoholic Fatty Liver Disease) Sicilia : which relationship of liver steatosis and concurrent fibrosis with heart function. RF‐2011‐ 02348429 Ageing at work: promoting health and safety of ageing workers according to changes of demography, labourmarket and social policies. MAGGIORE RF‐2011‐ 02349429 In vivo identification of molecular determinants critical to the metastatic process in melanoma. RF‐2011‐ 02347250 RF‐2011‐ 02348860 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Musculoskeletal, Oral and Skin Sciences Metabolism disorders and cardiovascular disease 17,5 Infectious Diseases and Microbiology The new biotechnologies 17,5 Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 17,5 Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 17,5 I.E.O. Biomedical Oncology 1 ‐ Basic Translational Oncology 17,5 Vitamin D as a disease modulator in multiple sclerosis: immunomodulatory activity on antigen presenting cell and gamma/delta T lymphocytes and regulation of their cross‐talk ISS Biomedical Immunology Neurological diseases 17,5 The potential of the SRCIN1/p140Cap gene as prognostic risk factor and tumor suppressor in neuroblastoma GASLINI Biomedical Oncology 1 ‐ Basic Translational Oncology 17,5 Biomedical Clinical Pagina 140 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02347668 Oxidative stress in animal cancer stem cells: IZS Piemonte, Liguria e biological mechanisms involved in the Valle d'Aosta pathogenesis of mammary spontaneous tumors Biomedical Oncology 1 ‐ Basic Translational Oncology 17,5 RF‐2011‐ 02349935 HIV eradication: pharmacological modulation of HIV latent reservoir by targeting of sirtuin family of de‐acetylating enzymes Sicilia Biomedical AIDS and Related Research Infection and immunity 17,5 RF‐2011‐ 02347252 Targeting endothelin‐1/ß‐arrestin signaling to circumvent chemoresistance in epithelial ovarian cancer REGINA ELENA Biomedical Oncology 2 ‐ Translational Clinical Oncology 17,5 RF‐2011‐ 02351932 Behavioural and neurophysiological aspects of communicative‐pragmatic abilities in healthy individuals and pathological conditions: assessment and rehabilitation MEDEA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 17,5 RF‐2011‐ 02348350 Treatment of advanced or recurrent endometrial cancer: identification of molecular predictors of response in a randomized phase II study with Bevacizumab in combination to Carboplatin‐Paclitaxel IST.TUMORI MILANO Clinical Oncology 2 ‐ Translational Clinical Oncology 17,75 RF‐2011‐ 02348683 Multimodal nanotechnological approach against hepatocellular carcinoma: Sorafenib loaded magnetic nanoparticles for targeted chemotherapy and localized hyperthermia. Toscana Biomedical Oncology 2 ‐ Translational Clinical Oncology 17,75 AREA STRATEGICA SCORE. Pagina 141 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349144 Identification and biomolecular characterization of circulating tumor cells from patients with ovarian epithelial cancer using tumor‐specific fluorescent ligands: A new in vivo non‐invasive method. I.E.O. RF‐2011‐ 02349830 Pathophysiological approach to the interventional therapy of limb atherosclerotic disease ‐ A biomedical, mechanistic study Emilia‐Romagna RF‐2011‐ 02349231 DEVELOPMENT OF ADVANCED NANOTECHNOLOGIES FOR EARLY ALZHEIMER DIAGNOSIS: FROM THE SYNTHESIS TO THE CLINICAL VALIDATION RF‐2011‐ 02351195 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 2 ‐ Translational Clinical Oncology 18 Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 18 Puglia Biomedical Bioengineering Sciences and Technologies Neurological diseases 18 The activation of vestibular system as a possible tool for inducing analgesia, speeding up recovery from stroke and facilitating recovery from vegetative and minimal conscious state Toscana Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 18 RF‐2011‐ 02348945 Development of innovative compounds for the treatment of renal cell carcinoma Abruzzo Biomedical Oncology 2 ‐ Translational Clinical Oncology 18 RF‐2011‐ 02350807 Safety of workers with implanted medical devices in MRI environment: criteriafor occupational risk evaluation ISS Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering Diseases of environmental origin, with reference also to the workplace 18 RF‐2011‐ 02352293 DENOSUMAB FOR THE TREATMENT OF SYSTEMIC SCLEROSIS RELATED OSTEOPOROSIS: AN OPEN‐LABEL PILOT SAFETY STUDY. Basilicata Musculoskeletal, Oral and Skin Sciences The new biotechnologies 18 Clinical Pagina 142 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352264 Epigenetic change in DNA structure may serve as marker for neurological disease Marche RF‐2011‐ 02347774 Therapeutic strategies in refractory chronic daily headache: A multicenter, randomized, controlled trial. Ist.Sci. Neurologiche Bologna RF‐2011‐ 02352259 Occupational and non‐occupational risk factors for retinal detachment: a multicentre population‐based case‐control study Emilia‐Romagna RF‐2011‐ 02346859 Memory training with transcranial direct current stimulation (tDCS) and cognitive reserve in Multiple Sclerosis and Alzheimer disease. A longitudinal clinical and MRI study Lombardia RF‐2011‐ 02351259 Pre‐eclampsia: the role of genetics in understanding the etiopathogenesis and evaluation of early predictive biomarkers RF‐2011‐ 02350698 Development of functionalized magnetic nanoparticles (VIVIT‐MNP) for IBD treatment: possible involvement of NFAT transcription factor RF‐2011‐ 02349911 Impact of JC and BK polyomaviruses Emilia‐Romagna infection on human infertility and recurrent pregnancy loss Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 18 Clinical Emerging Technologies and Training in Neurosciences Neurological diseases 18 Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 18 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 18 SAN RAFFAELE Milano Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies 18 Lombardia Biomedical Bioengineering Sciences and Technologies The new biotechnologies 18 Biomedical Infectious Diseases and Microbiology Infection and immunity 18 Biomedical Pagina 143 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02346963 Role of GALNT2 on glucose homeostasis. A multidisciplinary approach including cell biology, animal and human studies. RF‐2011‐ 02351153 DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 18 A genomic and proteomic approach to ISS explore phenotype variability in Gerstmann‐ Sträussler‐Scheinker syndrome (GSS) linked to P102L mutation in the PRNP gene Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 18 RF‐2011‐ 02349087 Oleuropein aglycone can be effective against AD in humans. A clinical trial Toscana Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 18 RF‐2011‐ 02352234 Non‐Invasive Monitoring of Circadian Rhythm Disorders In Shift‐workers I.N.R.C.A. Clinical Biobehavioral and Behavioral Processes Diseases of environmental origin, with reference also to the workplace 18 RF‐2011‐ 02350185 Identification and protein profiling of Piemonte extracellular vesicles in the cerebrospinal fluid of patients with Mild Cognitive Impairment and Alzheimer¿s disease: a new potential diagnostic tool Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 18 RF‐2011‐ 02348872 The role coagulation/complement upregulation and neurotropic viral activation play in Multiple Sclerosis Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 18 RF‐2011‐ 02348718 Telomere‐targeting agents: Towards clinical REGINA ELENA candidates selections Biomedical Oncology 2 ‐ Translational Clinical Oncology 18 RF‐2011‐ 02352789 Study of molecular based approach for the epidemiological characterization of strains of Listeria monocytogenes isolated in food and human cases in Italy Biomedical Veterinary Food safety and animal welfare 18 CASA SOLLIEVO SOFFERENZA REGINA ELENA IZS Abruzzo e del Molise Pagina 144 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351926 High resolution molecular cytogenetics in colorectal cancer and oral premalignant lesions. Sicilia RF‐2011‐ 02352337 Chemoprevention of radiation damages induced by radiodiagnostic procedures REGINA ELENA RF‐2011‐ 02350573 Organic pollutant and plastic‐associated chemical effects on cardiovascular diseases: a sex‐gender issue Toscana RF‐2011‐ 02347143 Cockayne syndrome: the role of bioenergetics dysfunction in neurodegeneration and design of new therapeutic approaches ISS RF‐2011‐ 02350671 Cancer and adolescence: what clinical and sociological approach? A preliminary project in Italy C.R.O. AVIANO RF‐2011‐ 02351058 New targets for therapy in breast cancer: dietary induced inhibition of mammalian target of rapamycin (mTOR) SDN RF‐2011‐ 02351357 Inhibition of the Hedgehog Signaling Pathway for the Treatment of Patients with Osteosarcoma Toscana Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 1 ‐ Basic Translational Oncology 18 Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering Oncology 18 Clinical Cardiovascular and Respiratory Sciences Diseases of environmental origin, with reference also to the workplace 18 Molecular, Cellular, and Developmental Neuroscience Neurological diseases 18 Healthcare Delivery and Methodologies Oncology 18 Biomedical Oncology 2 ‐ Translational Clinical Oncology 18 Biomedical Oncology 2 ‐ Translational Clinical Oncology 18 Biomedical Clinical Pagina 145 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348168 OBESITY AND DIABETES/HYPERTENSION RISK IN CHILDREN: PREVENTION AND TREATMENT THROUGH MONITORED PHYSICAL ACTIVITY and NUTRITION PROGRAMS SAN RAFFAELE Pisana‐ Roma RF‐2011‐ 02349703 Lipoprotein(a) and soluble lectin‐like oxidized LDL receptor‐1 (sLOX‐1) as a potential causal genetic risk factor for atherosclerosis in a prospective population‐ based study (PLIC study) Lazio RF‐2011‐ 02347102 Liver targeted cell therapy: applications to experimental Glycogen Storage Disease type 1a RF‐2011‐ 02349684 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 18 Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 18 GASLINI Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 18 Food Safety: protection of the public health through the determination of some endocrine disruptors in water and foods of large consumption IZS Mezzogiorno Biomedical Veterinary Food safety and animal welfare 18 RF‐2011‐ 02348553 IS THERE A "SMELLING SIDE" IN THE HUMAN MOTOR SYSTEM? Towards a clinical relevance of olfacto‐motor cross‐ modal intercations Toscana Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 18 RF‐2011‐ 02349679 Counteracting oxidative stress in Rett syndrome ISS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 18 RF‐2011‐ 02348388 Mechanism of action and in vivo efficacy of anti‐inflammatory treatments in Treg induction, regulation of neuroinflammation and arrest of dementia progression. NEUROLESI Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 18 Pagina 146 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347898 Cystic Lesions of the Pancreas: Creation of a Sicilia Database and a New Evidence‐Based, CostEffective Algorithm RF‐2011‐ 02350409 PYB ‐ Protect Your Back (Effectiveness of Back Protector in preventing spinal cord injuries) RF‐2011‐ 02352285 Early discharge from the emergency Toscana department of nursing‐home dwelling older patients with community acquired pneumonia in comparison to normal hospitalization: a randomized clinical trial RF‐2011‐ 02352004 A novel TRAIL‐based therapeutic by mesenchymal cells TARgeting PAncreatic Cancer (TARPAC) Emilia‐Romagna RF‐2011‐ 02351410 Nuclear Signaling Mediated by the Innate Immune/Inflammtory Kinase PKR as a Therapeutic Target and Prognostic Indicator of Disease Progression and Therapeutic Response in Myelodysplastic Syndromes and Acute Leukemia RF‐2011‐ 02349551 EXOME SEQUENCING BASED DETECTION OF VARIANTS RELEVANT TO THE CLINICAL SPECTRUM OF NEONATAL BRONCHO PULMONARY DYSPLASIA AND RESPIRATORY DISTRESS Tipologia AREA STRATEGICA SCORE. Digestive, Kidney and Urological Systems Oncology 18 Risk, Prevention and Health Behavior Neurological diseases 18 Healthcare Delivery and Methodologies Infection and immunity 18 Biomedical Oncology 1 ‐ Basic Translational Oncology 18 RIZZOLI Biomedical Vascular and Hematology Oncology 18 SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics The new biotechnologies 18 ISS Clinical Classificazione 1 Liv. Biomedical Clinical Pagina 147 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351462 Biological endophenotypes associated to the electroconvulsive therapy in treatment resistant depression. RF‐2011‐ 02349793 Correlation between estrogen depletion and OASI MARIA S.S. Alzheimer¿s disease: analysis of gene expression and brain functions in humans and animal models RF‐2011‐ 02351843 Reduction of atrial fibrillation and stroke in SAN DONATO systemic arterial hypertension: a randomized control trial comparing routine Provincia autonoma Bolzano Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Biobehavioral and Behavioral Processes Neurological diseases 18 Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 18 Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 18 Clinical medical treatment versus primary care physicians guided drug regiment delivery through intensive blood pressure monitoring RF‐2011‐ 02348165 Development of a multi‐stage vaccine against tuberculosis Veneto Biomedical Immunology Infection and immunity 18 RF‐2011‐ 02346978 Improving radiotherapy of high grade gliomas by Ataxia Telangiectasia Mutated protein inhibition AOU San Martino‐IST ‐ Genova Biomedical Brain Disorders and Clinical Neuroscience Oncology 18 RF‐2011‐ 02348623 Implementation of the Montreal Cognitive Assessment as a standard neuropsychological screening tool in Italian stroke units Toscana Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 18 Pagina 148 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350636 Occupational Mycobacterium tuberculosis infection among healthcare workers: assessing the burden and developing modern strategies for risk assessment and health surveillance SPALLANZANI RF‐2011‐ 02352708 Study of new biomarkers for diagnoses of disorders of bile acid synthesis by mass spectrometry and metabolomics approach Veneto RF‐2011‐ 02347562 CLINICAL RELEVANCE OF IMMUNE RESPONSES TO PROPHYLACTIC HPV VACCINE IN ITALY: A NATIONAL IMMUNOMONITORING NETWORK ISS RF‐2011‐ 02351838 Study on the use of vodcast in the treatment of Anorexia Nervosa Veneto Clinical RF‐2011‐ 02350928 Genetic polymorphisms in genes of drug‐ related and DNA repair pathways as predictive markers of the therapeutic efficacy in esophageal carcinoma I. O. V. Biomedical RF‐2011‐ 02349249 The early identification of newborns at high Toscana risk of brain injury: the role of oxidative stress. RF‐2011‐ 02350302 Translational value of pathophysiological pathways and therapeutic agents on lipid dysmetabolism in the hepatobiliary and cardiovascular system: a bench‐to‐bedside project. Puglia Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 18 Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 18 Biomedical Immunology Infection and immunity 18 Biobehavioral and Behavioral Processes Neurological diseases 18 Oncology 2 ‐ Translational Clinical Oncology 18 Brain Disorders and Clinical Neuroscience Neurological diseases 18 Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 18 Clinical Biomedical Pagina 149 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349259 Two innovative rapid screening methods of corticosteroids as growth‐promoters in cattles using MEAs and an enhanced histopathological approach IZS Piemonte, Liguria e Valle d'Aosta Biomedical Veterinary Food safety and animal welfare 18 RF‐2011‐ 02351554 Mechanisms of extracranial organ damage after acute brain injury: role of protective mechanical ventilation in reducing incidence of acute respiratory distress syndrome and attenuating systemic inflammation in acute neurologically ill patients Piemonte Biomedical Cardiovascular and Respiratory Sciences Neurological diseases 18 RF‐2011‐ 02347029 Treatment of Subsyndromal Delirum (SSD) and long term Cognitive Dysfunction after Cardiac Surgery. Evaluation of possible neural mechanism underlyning Delirium Emilia‐Romagna Integrative, Functional, and Cognitive Neuroscience Neurological diseases 18 RF‐2011‐ 02347598 Impact of HIV on the pathogenesis of Mycobacterium tuberculosis: autophagy involvement and new pharmacological target SPALLANZANI Infectious Diseases and Microbiology Infection and immunity 18,25 RF‐2011‐ 02350852 Phase I/II clinical trial of dendritic cell therapy for the treatment of metastatic melanoma based on an innovative way to generate a whole repertoire of tumor peptides via gap junction pores I.E.O. Clinical Oncology 2 ‐ Translational Clinical Oncology 18,25 RF‐2011‐ 02351978 THROMBOTIC MARKERS AS INNOVATIVE TOOLS FOR CANCER PROGNOSIS IN ONCOLOGICAL PATIENTS UNDERGOING HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY Lombardia Biomedical Oncology 2 ‐ Translational Clinical Oncology 18,25 Clinical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 150 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348646 EFFECTS OF BLUNTING DAILY GLUCOSE FLUCTUATIONS ON COGNITIVE PERFORMANCE IN AGED TYPE 2 DIABETIC PATIENTS I.N.R.C.A. RF‐2011‐ 02351994 FUNCTIONAL PROFILING OF MONOCYTE/MACROPHAGE POPULATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA: INVOLVEMENT IN CLINICAL OUTCOME Emilia‐Romagna RF‐2011‐ 02351975 Daily monitoring of pediatric asthmatic outpatients: environment and health relationship. OSPEDALE BAMBINO GESU' RF‐2011‐ 02348324 Cellular autoimmunity and causative autoantigens in acquired thrombotic thrombocytopenic purpura (TTP) MAGGIORE RF‐2011‐ 02348270 Exploiting cellular transcription factors of the Interferon Regulatory Factors family in novel therapeutic approaches to HIV‐1 infection and reactivation from latency RF‐2011‐ 02352310 RF‐2011‐ 02352084 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease Oncology 1 ‐ Basic Translational Oncology 18,5 Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 18,5 Biomedical Immunology Infection and immunity 18,5 ISS Biomedical AIDS and Related Research Infection and immunity 18,5 Systemic and local characterization of clinical remission in rheumatoid arthritis patients treated with biologic agents: predictors, dynamics and pathologic stability. SAN MATTEO Biomedical Musculoskeletal, Oral and Skin Sciences Infection and immunity 18,5 Human Cardiac Stem Cell Regenerative Capacity in Paediatric Heart Failure Lazio Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 18,5 Biomedical Clinical 18,25 Pagina 151 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02352085 Genetic and Antigenic Evolution of West Nile virus Isolated in Italy and Characterization of Viral‐Host Mechanisms Regulating Infection and Pathogenesis IZS Abruzzo e del Molise Biomedical Veterinary Food safety and animal welfare 18,5 RF‐2011‐ 02351746 RISK OF INFECTION IN RHEUMATOID ARTHRITIS (RA): INVOLVEMENT OF INNATE IMMUNITY AND BIOLOGIC THERAPIES. Campania Biomedical Immunology Infection and immunity 18,5 RF‐2011‐ 02348856 Superpolyps: superantigen‐induced T‐ and B‐cell accumulation in nasal polyps Lombardia Clinical Infectious Diseases and Microbiology Infection and immunity 18,5 RF‐2011‐ 02348593 Biomolecular serological and epidemiological investigations on Encefalomyocarditis virus and his zoonotic roles in Italy. IZS Lombardia e dell'Emilia Biomedical Veterinary Food safety and animal welfare 18,5 RF‐2011‐ 02347791 Development and implementation of a protocol for communication of genetic information and multidisciplinary genetic counseling in ALS, in parallel with identification of early alterations in pre‐ symptomatic ALS. Piemonte Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 18,5 RF‐2011‐ 02352587 PREDICTION OF AWAKENING FROM ACUTE COMA, USING THE BRAIN REACTIVITY TO PAIN‐RELATED‐ SOMATOSENSORY EVOKED POTENTIALS. Veneto Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 18,5 AREA STRATEGICA SCORE. Pagina 152 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352590 microRNAs and Single Nucleotide Polymorphisms as potential screening biomarkers for early detection of colorectal cancer. Toscana RF‐2011‐ 02351805 Appropriateness of systemic anticancer therapy in advanced cancer patients: the use of AIFA monitored antineoplastic drugs in the end of life in Regione Emilia‐ Romagna Emilia‐Romagna RF‐2011‐ 02347999 A Web Intelligence approach to the patient empowerment: exploring knowledge on internet conversations C.R.O. AVIANO RF‐2011‐ 02347865 New insights for Attention Deficit and Hyperactivity Disorder (ADHD): novel serotonin 7 receptor agonist drugs for putative therapy, and clinical validation of the circulating auto‐Antibodies against DAT as a bio‐marker for diagnosis. ISS RF‐2011‐ 02347870 miRNA in the blood as biomarkers and therapeutic indicators of progressive tissue degeneration in Glycogen Storage Disease type 1a patients GASLINI RF‐2011‐ 02346883 Expression of indoleamine 2,3‐dioxygenase 1 OSPEDALE BAMBINO (IDO1) in childhood acute leukemia: GESU' mechanisms of induction/regulation and clinical implications for leukemia control and patient survival. Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 1 ‐ Basic Translational Oncology 18,5 Clinical Healthcare Delivery and Methodologies Oncology 18,5 Clinical Healthcare Delivery and Methodologies Oncology 18,5 Biomedical Biobehavioral and Behavioral Processes Neurological diseases 18,5 Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 18,5 Biomedical Immunology Oncology 18,5 Pagina 153 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347105 Novel Plasmodium falciparum cell‐based assays for new antimalarial drugs ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 18,5 RF‐2011‐ 02352217 MITOCHONDRIAL CI and CIV DEFICIENCIES: DIFFERENT CLINICAL AND BIOCHEMICAL RENSPONSE TO EPI‐ 743. AN INTEGRATED APPROACH TO IMPROVE BOTH THE CLINICAL MANAGEMENT AND THE UNDERSTANDING OF THE PATHOGENESIS OF THIS DISORDER OSPEDALE BAMBINO GESU' Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 18,5 RF‐2011‐ 02351369 Measuring outcomes to estimate the value of health interventions in breast cancer care C.R.O. AVIANO Clinical Healthcare Delivery and Methodologies Oncology 18,5 RF‐2011‐ 02349727 How is it possible to define rehabilitation care appropriateness? The impact of an alternative evaluation system on the inappropriateness of health care resources Emilia‐Romagna Clinical Healthcare Delivery and Methodologies Neurological diseases 18,5 RF‐2011‐ 02349456 Pulmonary Rehabilitation in Lung Cancer surgical patients. SAN RAFFAELE Pisana‐ Roma Clinical Cardiovascular and Respiratory Sciences Oncology 18,5 RF‐2011‐ 02349065 MULTIMODAL APPROACH TO PERSONALIZED THERAPY IN ANAL CANCER: CREATION OF A BIOMARKER PREDICTIVE PROFILE ADDRESSING TOWARDS NEW THERAPUTIC STRATEGIES Piemonte Clinical Oncology 2 ‐ Translational Clinical Oncology 18,5 RF‐2011‐ 02350338 Mechanisms of diabetes resolution after bariatric surgery: role of the gut Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 18,5 Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 154 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349855 Comparative study on the clinical efficacy and manegement of different feeding strategies in elderly patients with advanced dementia. Veneto RF‐2011‐ 02349592 Mechanism(s) underlying differential protection of trastuzumab‐containing therapy depending on site of relapse. IST.TUMORI MILANO RF‐2011‐ 02351243 Smoking reduction in a population at high risk of cardiovascular mortality. Randomized control trial of intervention to implement and improve tobacco control strategies in psychiatric settings versus combined pharmacological and psychological intervention Provincia autonoma Trento RF‐2011‐ 02350440 Fighting drug resistance in non‐small cell lung cancer (NSCLC): a combinatorial approach based on anti‐Kit ligand vaccination Piemonte RF‐2011‐ 02350942 Risk of human and animal exposure to cyanotoxins through fresh‐ and brackish‐ water reared organisms in connected ponds systems IZS Sardegna RF‐2011‐ 02349504 In vivo manipulation of gamma delta Tcell with zoledronate and low dose IL2: improving the efficacy of BRAF inhibitors through a combined targeted/immunotherapy in metastatic melanoma. Sicilia Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Neurological diseases 18,5 Oncology 2 ‐ Translational Clinical Oncology 18,5 Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease 18,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 18,5 Biomedical Veterinary Food safety and animal welfare 18,5 Oncology 2 ‐ Translational Clinical Oncology 18,5 Biomedical Clinical Clinical Pagina 155 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02348926 HOMEOSTASIS OF pH AND BICARBONATE CONCENTRATION IN THE AIRWAY SURFACE FLUID AS A TARGET FOR THE TREATMENT OF RESPIRATORY INFECTIONS IN CYSTIC FIBROSIS AND OTHER CHRONIC LUNG DISEASES GASLINI Biomedical Cell Biology Infection and immunity 18,5 RF‐2011‐ 02351606 A novel approach for detecting vector‐ borne viruses in Sardinia and evaluation of Bluetongue virus evolution. IZS Abruzzo e del Molise Biomedical Veterinary Food safety and animal welfare 18,5 RF‐2011‐ 02350946 Evaluation of clinical feasibility and effectiveness of a robotic device for early stage rehabilitation of stroke patients Provincia autonoma Bolzano Biomedical Emerging Technologies and Training in Neurosciences Neurological diseases 18,5 RF‐2011‐ 02349457 Congenital cytomegalovirus infection: prognostic factors of virus transmission to the fetus and congenital disease SAN MATTEO Biomedical Infectious Diseases and Microbiology Infection and immunity 18,5 RF‐2011‐ 02349749 NEW ANTIBACTERIAL COATINGS FOR TITANIUM PROSTHESIS TO REDUCE PERIMPLANT INFECTIVE RISK AND IMPROVE OSSEOINTEGRATION RIZZOLI Biomedical Musculoskeletal, Oral and Skin Sciences The new biotechnologies 18,5 RF‐2011‐ 02349452 Generation of human artificial striated muscle MULTIMEDICA Biomedical Bioengineering Sciences and Technologies The new biotechnologies 18,5 RF‐2011‐ 02351704 Implementation of a pathology network to improve identification and clinical management of patients with familial hypercholesterolemia MULTIMEDICA Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 18,5 AREA STRATEGICA SCORE. Pagina 156 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347164 The clinical significance of the association between REM Sleep Behavior Disorder and Parkinson's Disease OASI MARIA S.S. Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 18,75 RF‐2011‐ 02349886 BIOLOGICAL AGING AND URBAN POLLUTION Veneto Biomedical Cardiovascular and Respiratory Sciences Diseases of environmental origin, with reference also to the workplace 18,75 RF‐2011‐ 02351450 Alteration of steroid hormone pathways PASCALE and vitamin D in testicular germ cell tumors Biomedical Oncology 2 ‐ Translational Clinical Oncology 18,75 RF‐2011‐ 02352633 MEDITERRANEAN DIET AND RECURRENCE OF COLORECTAL ADENOMA AND CANCER : A RANDOMIZED CONTROLLED TRIAL DE BELLIS Biomedical Risk, Prevention and Health Behavior Oncology 19 RF‐2011‐ 02350684 Impact of the association between elastography and fine‐needle aspirate mutational testing in the prediction of malignancy of thyroid nodules with indeterminate cytology: a prospective analysis. Emilia‐Romagna Oncology 2 ‐ Translational Clinical Oncology 19 RF‐2011‐ 02347689 Role of Type I Interferon in the Cross‐talk between Neutrophils and Dendritic Cells in the induction of adaptive immunity during Mycobacterium tuberculosis and BCG infections. ISS Biomedical Immunology Infection and immunity 19 RF‐2011‐ 02351908 Development of an artificial larynx for clinical applications Toscana Biomedical Biobehavioral and Behavioral Processes The new biotechnologies 19 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 157 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349875 Developmemt of a novel intra‐operative spectroscopic diagnostic technology for diagnosis and better delineation of human brain tumours. Toscana Biomedical Oncology 2 ‐ Translational Clinical Neurological diseases 19 RF‐2011‐ 02351560 Integration of Diagnostic tools for fibromyalgia: can tailored therapies be more effective and less expensive? Piemonte Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 19 RF‐2011‐ 02350218 Predictive value of invasive measurement of Sicilia left ventricular function during cardiac resynchronization therapy (CRT). Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 19 RF‐2011‐ 02352680 Multifunctional Targeted Nanoparticles for minimally Invasive Diagnosis and Therapy of Inflammatory Bowels Diseases and their displasic lesions. I. O. V. Biomedical Digestive, Kidney and Urological Systems The new biotechnologies 19 RF‐2011‐ 02346887 Bowel microbiota and chronic inflammatory bowel diseases: a metabolomic approach Sardegna Biomedical Infectious Diseases and Microbiology Infection and immunity 19 RF‐2011‐ 02350113 Cognitive rehabilitation after stroke: a randomized controlled trial to compare the effectiveness of different protocols. Sicilia Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 19 RF‐2011‐ 02350561 The early diagnosis of Alzheimer disease: new tools for the olfactory dysfunction evaluation. Toscana Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 19 RF‐2011‐ 02347264 Molecular techniques as epidemiological tools to answer some of the queries about Q fever IZS Venezie Veterinary Food safety and animal welfare 19 Clinical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 158 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347881 Development of a novel immunotherapeutic approach to contrast prion‐mediated Abeta oligomer neurotoxicity by intracellular antibody technology SAN RAFFAELE Pisana‐ Roma RF‐2011‐ 02348527 MIND THE GAP: END‐OF‐LIFE IN ADVANCED HEART FAILURE. IMPROVING QUALITY AND CARE OPTIONS. Toscana RF‐2011‐ 02350943 Finding of common potential new biomarkers for development of diagnostic tools in different neurodegenerative diseases and discovery of new therapeutic agents IZS Sicilia RF‐2011‐ 02347871 Identification of novel molecular mechanisms promoting oncogenic RAS signaling ISS RF‐2011‐ 02351471 RF‐2011‐ 02349480 Tipologia AREA STRATEGICA SCORE. Brain Disorders and Clinical Neuroscience Neurological diseases 19 Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 19 Biomedical Cell Biology Neurological diseases 19 Biomedical Oncology 1 ‐ Basic Translational Oncology 19 EFFECT OF ATORVASTATIN ON Veneto OXIDATIVE STRESS AND INFLAMMATION AND ON OXIDATIVE STRESS‐INDUCED UNFOLDED PROTEIN RESPONSE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: RELATION WITH ARTERIAL STIFFNESS AND LUNG FUNCTION DECLINE Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 19 Lentiviral‐mediated telomere stabilization in hematopoietic stem cell transplantation for graft improvement and GVHD reduction in thalassemia patients Clinical Vascular and Hematology The new biotechnologies 19 Sardegna Biomedical Classificazione 1 Liv. Clinical Pagina 159 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351943 Report‐AGE Project: clinical and molecular predictors of frailty in aged hospitalized populations with cardiovascular diseases I.N.R.C.A. RF‐2011‐ 02349265 Ultrasound on bioeffects and safety: an integrated approach in evaluating ultrasound‐mediated cell alterations at both cell membrane and genetic level INAIL RF‐2011‐ 02348312 Fractal Lacunarity of Trabecular Bone in Magnetic Resonance Images of Lumbar Vertebras: Clinical Validation of a New Diagnostic Tool for Osteoporosis and Fracture Risk I.N.R.C.A. RF‐2011‐ 02349740 Cellular biomarkers of diabetic pathophysiology and complications Veneto RF‐2011‐ 02351818 Developement and characterization of a new single step treatment for multiple orthopaedic diseases affecting bone or cartilage with the use of bone marrow derived cells and collagenic scaffold RF‐2011‐ 02352814 RF‐2011‐ 02351934 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Biology of Development and Aging Metabolism disorders and cardiovascular disease 19 Cell Biology Diseases of environmental origin, with reference also to the workplace 19 Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 19 Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 19 RIZZOLI Biomedical Bioengineering Sciences and Technologies The new biotechnologies 19 (SIMBA) Simulation Interface for Miniaturized preterm BAby respiratory system model Toscana Clinical Bioengineering Sciences and Technologies The new biotechnologies 19 Metabolomics of Multiple Myeloma SAN RAFFAELE Milano Oncology 1 ‐ Basic Translational Oncology 19 Biomedical Clinical Biomedical Pagina 160 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02350730 Optimization, on the basis of Monte Carlo Sicilia dosimetry, of the therapeutical effectiveness and toxicity of Peptide Receptor Radionuclide Therapy in patients with neuroendocrine tumors Clinical Oncology 2 ‐ Translational Clinical Oncology 19 RF‐2011‐ 02349002 Nanoparticle‐Enhanced Surface Plasmon Resonance Imaging (NE‐SPRI): PCR‐free ultrasensitive cancer prognosis and therapy prediction REGINA ELENA Clinical Oncology 2 ‐ Translational Clinical The new biotechnologies 19 RF‐2011‐ 02350330 Using available stimulation techniques to delay the onset of dementia S.CAMILLO Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 19 RF‐2011‐ 02351655 Identification of molecular targets and markers to manage hormone‐resistant obesity‐associated breast cancer: from in vitro and in vivo models to human tumors Piemonte Biomedical Oncology 2 ‐ Translational Clinical Oncology 19 RF‐2011‐ 02347968 Project title: CEACAM1 is a priviliged cell surface target antigen to design human mAbs in scFv format for multimodal immunotherapeutic intervention of melanoma and lung carcinoma. ISS Biomedical Bioengineering Sciences and Technologies The new biotechnologies 19 RF‐2011‐ 02347436 Effects of Neuropeptide Y on the central nervous system neurons of rat models of Alzheimer Disease SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 19 RF‐2011‐ 02351104 Antibiotic strategy and response to microbiologic tests: a study of appropriateness and promptness in case of sepsis. Piemonte Infectious Diseases and Microbiology Infection and immunity 19 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 161 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352076 Property of donkey's milk : application in human nutrition and its potential usein the preventions and therapy of metabolic infiammatory and cardiovascular diseases associated with obesity. IZS Mezzogiorno RF‐2011‐ 02350093 Early detection of cardiotoxicity in cancer patients ONCOLOGICO DI BARI RF‐2011‐ 02351426 ENDOCRINE AND INTRACRINE METABOLISM OF SEX STEROIDS ‐ PROSTATE HEALTH AND CANCER OUTCOMES FROM A 20‐YEAR POPULATION‐BASED STUDY RF‐2011‐ 02350453 Fertility preservation in young Oncological female patients RF‐2011‐ 02350026 RF‐2011‐ 02348106 Tipologia AREA STRATEGICA SCORE. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 19 Clinical Cardiovascular and Respiratory Sciences Oncology 19 SAN RAFFAELE Milano Clinical Oncology 2 ‐ Translational Clinical Oncology 19,25 REGINA ELENA Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Oncology 19,25 Proximal versus Distal approach in the SAN RAFFAELE Pisana‐ upper limb rehabilitation in stroke patients Roma using robotic platforms: effects on the motor performance and functional recovery. Clinical Biobehavioral and Behavioral Processes Neurological diseases 19,25 Alternative strategies for cognitive rehabilitation after stroke: which role for not invasive brain stimulation? Effects of transcranial magnetic stimulation in recovery of hemispatial attention and language in subacute and chronic patients. Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 19,5 Sicilia Biomedical Classificazione 1 Liv. Pagina 162 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352295 NEUROPSYCHOLOGICAL AND fMRI STUDIES TO EVALUATE THE EFFECTS OF COGNITIVE REHABILITATION IN PARKINSON¿S DISEASE Provincia autonoma Trento RF‐2011‐ 02347760 Urine proteome analysis: A possible method that may allow noninvasive differential diagnosis of diabetic nephropathy andgive new insight into monogenic type 2 diabetes OSPEDALE BAMBINO GESU' RF‐2011‐ 02350975 Tipologia AREA STRATEGICA SCORE. Integrative, Functional, and Cognitive Neuroscience Neurological diseases 19,5 Biomedical Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 19,5 Immunological and virological predictors of SPALLANZANI clinical outcome in chronic HBV patients discontinuing anti‐viral treatment Biomedical Immunology Infection and immunity 19,5 RF‐2011‐ 02349348 Role of plasma dysregulated microRNAs in the diagnosis and screening of Human Malignant Pleural Mesothelioma (MPM) Biomedical Oncology 2 ‐ Translational Clinical Diseases of environmental origin, with reference also to the workplace 19,5 RF‐2011‐ 02350564 Effects of a late add‐on therapy of pegylated Lombardia interferon (peg‐IFN¿) to ongoing nucleos(t)ide analogs (NUCs) in patients with chronic hepatitis B (CHB): dissecting systemic and hepatic immune restoration Clinical Infectious Diseases and Microbiology Infection and immunity 19,5 RF‐2011‐ 02351852 zEC‐ zero Errors in Chemotherapy: process modelling for more effective ICT solutions in antiblastic treatment management I.E.O. Clinical Healthcare Delivery and Methodologies Oncology 19,5 RF‐2011‐ 02350811 The impact of HBV and HCV expression and replication on cellular differentiation, metabolism and oncogenesis in extra‐ or intra‐hepatic stem cells induced to differentiate along the hepatocytic lineage SPALLANZANI Biomedical Infectious Diseases and Microbiology Infection and immunity 19,5 Emilia‐Romagna Clinical Classificazione 1 Liv. Pagina 163 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350816 Rapid eye movement sleep behavior disorder (RBD): Prevalence study in Italian general population aged > 50 years SAN RAFFAELE Milano RF‐2011‐ 02352794 Development and monitoring of a Parkinson's disease network in Tuscany RF‐2011‐ 02349864 Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 19,5 Toscana Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 19,5 Discovery and translational research of aggressive B‐cell lymphomas of still unknown pathobiology Toscana Biomedical Oncology 1 ‐ Basic Translational Oncology 19,5 RF‐2011‐ 02350858 Predictive and prognostic value of molecular markers for glioma in clinical decision making CARLO BESTA Clinical Oncology 2 ‐ Translational Clinical Oncology 19,5 RF‐2011‐ 02351329 Identification of biomarkers associated with Toscana clinical response and/or toxicity to treatment with the JAK2 inhibitor ruxolitinib in patients with myelofibrosis Biomedical Oncology 2 ‐ Translational Clinical Oncology 19,5 RF‐2011‐ 02348548 High‐coverage next generation sequencing to detect the presence and intra‐tumor frequency of mutations in the EGFR pathway activating genes: predictive value on the response to anti‐EGFR therapy in metastatic colorectal cancer. AOU San Martino‐IST ‐ Genova Biomedical Oncology 2 ‐ Translational Clinical Oncology 19,5 RF‐2011‐ 02347285 SISTEMATIC APPLICATION OF A STANDARDIZED COMPREHENSIVE GERIATRIC ASSESSMENT TO PREDICT OUTCOME AND POSSIBILITY OF TREATMENT ON ELDERLY CANCER PATIENTS Emilia‐Romagna Clinical Oncology 2 ‐ Translational Clinical Oncology 19,5 Pagina 164 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349828 Exposure and health effects of Ultrafine Particles at urban hotspots RF‐2011‐ 02352021 Application of novel biotechnologies for IZS Abruzzo e del Molise assessment of the vector competence of wild populations of Culicoides obsoletus for the Bluetongue virus RF‐2011‐ 02349178 A Prospective Cohort Study to Evaluate the Prognostic Value of Mobile Genetic Element Insertions in Non‐Small Cell Lung Cancer (NSCLC). I.N.R.C.A. RF‐2011‐ 02350863 Characterization of molecular markers that are associated with DNA‐damage repair pathways to identify rectal cancer patients who are responsive to chemioradiotherapy Piemonte RF‐2011‐ 02349796 Definition of a new predictive model to assess the complexity of patients hospitalized in Internal Medicine, with particular reference to cardiovascular outcomes Lombardia RF‐2011‐ 02351539 Validation of a Prognostic Gene Signature in Urine Samples from Prostate Cancer Patients SAN RAFFAELE Milano RF‐2011‐ 02350423 New molecurar markers to characterize benign and malignant thyroid cells. Toscana INAIL Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 19,5 Biomedical Veterinary Food safety and animal welfare 19,5 Clinical Oncology 2 ‐ Translational Clinical Oncology 19,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 19,5 Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 19,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 19,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 19,5 Clinical Pagina 165 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347457 Post‐transplant hematopoiesis: a model to understand self‐renewal mechanisms of hematopoietic stem cells GASLINI Biomedical Vascular and Hematology Oncology 19,5 RF‐2011‐ 02352502 The gC1q domain of EMILIN1 as an ideal backbone to develop a versatile drug carrier C.R.O. AVIANO Biomedical Oncology 2 ‐ Translational Clinical Oncology 19,5 RF‐2011‐ 02350227 Genetic basis of taste perception, life style, health status and colorectal cancer risk. Piemonte Biomedical Genes, Genomes and Genetics Oncology 19,5 RF‐2011‐ 02348610 Personalized multidisciplinary therapy in head and neck cancer based on clinical and molecular markers C.R.O. AVIANO Oncology 2 ‐ Translational Clinical Oncology 19,5 RF‐2011‐ 02348921 Expression of PARP1 and LDOC1 genes in subjects with Down syndrome and identification of new markers of neurodegenerative disorders in these subjects. OASI MARIA S.S. Biomedical Genes, Genomes and Genetics Neurological diseases 19,5 RF‐2011‐ 02347702 The effects of intensive arm training on upper extremity motor recovery in chronic stroke survivors. Identification of biomarkers related to clinical outcome. Emilia‐Romagna Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 19,5 RF‐2011‐ 02349122 Evaluation of denosumab effects on RANKL/RANK signalling in human osteosarcoma cells. Abruzzo Biomedical Oncology 1 ‐ Basic Translational Oncology 19,5 RF‐2011‐ 02352782 Oxidative stress and vitamin D as potential contributors for cardiometabolic complications in subclinical and overt hypothyroidism. Toscana Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 19,5 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 166 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350092 Phase contrast mammography with synchrotron radiation in the follow‐up of patients treated with conservative surgery for breast carcinoma Friuli‐Venezia Giulia RF‐2011‐ 02349448 Genetic risk prediction of atrial fibrillation recurrences: new insight from next generation sequencing RF‐2011‐ 02349399 Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering Oncology 19,75 Emilia‐Romagna Clinical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 19,75 Antenatal human heart development Lombardia Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 19,75 RF‐2011‐ 02352025 Host‐pathogen interactions: Chlamydiae cronic infections; a primary role in human diseases. Biomarkers and diagnostic tools for clinical evaluation. Toscana Infectious Diseases and Microbiology Infection and immunity 19,75 RF‐2011‐ 02351323 Longitudinal comparative study to assess progression and predictive factors of ognitive decline in patients with advanced Parkinson's disease treated with deep brain stimulation of the subthalamic nucleus stimulation and pharmacological therapy S.CAMILLO Brain Disorders and Clinical Neuroscience Neurological diseases 19,75 RF‐2011‐ 02347194 INNOVATIVE TRANSLATIONAL APPROACHES TO IDENTIFY IMMUNE CORRELATES OF PROTECTION IN AIDS VACCINE TRIALS ISS AIDS and Related Research Infection and immunity 20 RF‐2011‐ 02348406 Decision making and learning impairments associated with focal cerebral lesions Lazio Integrative, Functional, and Cognitive Neuroscience Neurological diseases 20 Biomedical Clinical Biomedical Clinical Pagina 167 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02347582 Understanding high‐risk HPV‐induced derangements in cervical cancer to address patients' prognosis and therapy and to defeat the viral oncogenic machinery RF‐2011‐ 02352169 DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Oncology 1 ‐ Basic Translational Oncology 20 Investigations of the molecular mechanisms Toscana linking poly(ADP‐ribosyl)ation to relapses and progression of multiple sclerosis Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 20 RF‐2011‐ 02349782 In vitro and in vivo effects of post‐ transplant cyclophosphamide (PT‐CY) in patients receiving hematopoietic stem cell transplantation from HLA haploidentical family donors. AOU San Martino‐IST ‐ Genova Biomedical Oncology 2 ‐ Translational Clinical Oncology 20 RF‐2011‐ 02347552 Familial Hyperaldosteronism: Studies in Humans and in Animal Models Piemonte Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 20 RF‐2011‐ 02347506 GENE‐ENVIRONMENT INTERACTIONS, VITAMIN D STATUS AND SUSCEPTIBILITY: IMMUNE RESPONSE AND PULMONARY TUBERCULOSIS RISK IN SICILY Sicilia Biomedical Population Sciences and Epidemiology Infection and immunity 20 RF‐2011‐ 02347487 ROLE OF GROUP I METABOTROPIC GLUTAMATE RECEPTORS IN THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS AND IN ITS PHARMACOLOGICAL CONTROL I.N.R.C.A. Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 20 RF‐2011‐ 02348156 Radiation effects of low and/or protracted doses: from the mechanisms underlying the biological effects to the impact on public health ISS Biomedical Oncology 2 ‐ Translational Clinical Oncology 20 REGINA ELENA Pagina 168 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349586 ROLE AND IMPACT OF DNA VIRUSES IN AUTOIMMUNE DISEASES Emilia‐Romagna Biomedical Immunology Infection and immunity 20 RF‐2011‐ 02351075 Orthopoxvirus infection in Italy: diffusion and evaluation of innovative vaccine candidates SPALLANZANI Biomedical Infectious Diseases and Microbiology Infection and immunity 20 RF‐2011‐ 02351272 An integrated genomic and immunological approach to novel monitoring and therapeutic strategies for HBV and HCV infections Emilia‐Romagna Biomedical Infectious Diseases and Microbiology Infection and immunity 20 RF‐2011‐ 02352210 Achieving mucosal and systemic immunity by exploiting vitamin A metabolites as co‐ adjuvants in Tuberculosis vaccination ISS Biomedical Immunology Infection and immunity 20 RF‐2011‐ 02349584 Role of microRNAs in successful aging Abruzzo Biomedical Biology of Development and Aging Metabolism disorders and cardiovascular disease 20 RF‐2011‐ 02348269 Use of phages as decontamination agents in IZS Lombardia e dell'Emilia Biomedical the production of traditional Italian food: evaluation of effectiveness and possible risk for the consumer Veterinary Food safety and animal welfare 20 RF‐2011‐ 02349516 Guidelines for Health Impact Assessment Emilia‐Romagna Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 20 RF‐2011‐ 02349503 Searching for a common pathogenetic pathway causing muscle misfunctioning in different laminopathies RIZZOLI Cell Biology The new biotechnologies 20 Clinical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 169 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02352536 Gastrointestinal Tract Permeability and Emilia‐Romagna Inflammation in HIV‐Infected patients with mild to moderate Chronic Kidney Disease: a cross‐over, double blind, randomized clinical trial Biomedical AIDS and Related Research Infection and immunity 20 RF‐2011‐ 02350536 Improvement of diagnosis and immunotherapy appropriateness in mould allergic patients by characterization and standardization of mould allergenic extract. ISS Biomedical Immunology Diseases of environmental origin, with reference also to the workplace 20 RF‐2011‐ 02349704 Mechanism of inhibition and reversion of omega‐3‐Polyunsaturated Fatty Acids on the growth of intestinal polyps in APC Min/+ mice DE BELLIS Biomedical Oncology 1 ‐ Basic Translational Oncology 20 RF‐2011‐ 02347860 IMMUNOCARRIER DEVELOPMENT AND VALIDATION STUDY FOR TARGETED IMAGING/DRUGDELIVERY IN CANCER THERAPY SAN RAFFAELE Milano Biomedical Oncology 2 ‐ Translational Clinical Oncology 20 RF‐2011‐ 02347811 Abnormalities in T lymphocyte subsets and phagocytes in Cutaneous T‐cell Lymphomas (CTCL): potential mechanisms driving immunodeficiency and increased susceptibility to infections. Piemonte Biomedical Immunology Infection and immunity 20 RF‐2011‐ 02352720 Improving clinical pathways of patients candidated to cardiac surgery by process modeling MONZINO Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 20 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 170 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02352725 Identification of novel markers of disease through the analysis of the role and impact of mesenchymal stem cells and of miRNA/mRNA network on the progression of bicuspid aortic valve‐related aortopathy Campania Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 20 RF‐2011‐ 02352672 Changing professional behaviors and measuring the quality of acute stroke care CASA SOLLIEVO SOFFERENZA Biomedical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 20 RF‐2011‐ 02350634 Papillary Thyroid Cancer gender disparity: is the estrogen cancerogenesis related to stemness factors? Veneto Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Oncology 20 RF‐2011‐ 02351485 Clinical relevance of biomarkers involved in Campania EGFR signalling pathway in the outcome of KRAS wild‐type colorectal cancer patients treated with cetuximab‐based therapy Oncology 2 ‐ Translational Clinical Oncology 20 RF‐2011‐ 02350718 SARCOGLYCANS: SIGNALLING FUNCTION IN DIFFERENT CELLULAR COMPARTMENTS AND POSSIBLE ROLE INGENETIC THERAPIES. NEUROLESI Genes, Genomes and Genetics The new biotechnologies 20 RF‐2011‐ 02352279 The role of the airways microbiome in the development of chronic lung infections in CF patients and implications for personalized antibiotic interventions Provincia autonoma Trento Biomedical Infectious Diseases and Microbiology Infection and immunity 20 RF‐2011‐ 02350923 Producing iPS cells: a biobank service for translational genetic research Liguria Genes, Genomes and Genetics The new biotechnologies 20 Clinical Biomedical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 171 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02352287 Gender and age‐related differences in motility and permeability responses in human colon: role of muscarinic receptors DE BELLIS Biomedical RF‐2011‐ 02350719 ROLE OF WT1 AND ITS ISOFORMS IN HEMATOPOIETIC MALIGNANCIES Campania RF‐2011‐ 02349104 Impact of early extracorporeal Friuli‐Venezia Giulia photopheresis (ECP) on the management of acute Graft versus host disease (aGVHD): clinical, biological and economical implications RF‐2011‐ 02347864 Molecular diagnosis of thyroid nodules: evaluation of candidate microRNA in fine‐ needle aspiration biopsy samples and use of circulating microRNA as potential biomarkers to differentiate malignant from benign undetermined nodules. Toscana RF‐2011‐ 02351864 Safety and nutritional adequacy of donkey's milk in treating cow's milk allergic children Piemonte Clinical RF‐2011‐ 02347154 Potential health and environmental risks associated to air pollutants in the petrochemical site of Basilicata Basilicata RF‐2011‐ 02351778 Novel molecular mechanisms in pathogenesis of Male Breast Cancer (MBC) Sicilia Classificazione 1 Liv. AREA STRATEGICA SCORE. Digestive, Kidney and Urological Systems Metabolism disorders and cardiovascular disease 20 Clinical Genes, Genomes and Genetics Oncology 20 Clinical Immunology The new biotechnologies 20 Oncology 2 ‐ Translational Clinical Oncology 20 Immunology Food safety and animal welfare 20 Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 20 Biomedical Genes, Genomes and Genetics Oncology 20 Biomedical Pagina 172 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02347785 Detection of thyroid cancer biomarkers by SEREX: development of a new diagnostic assay and identification of targets for immunotherapy. Campania Biomedical RF‐2011‐ 02347171 Assessment of cancer risk behaviours of immigrant population in Italy and the impact in the socio‐sanitary context. Strategies for a conscious prevention. PASCALE Clinical RF‐2011‐ 02352624 Endocrine‐metabolic pattern and Mediterranean Diet biomarkers in the occurrence of breast cancer relapses IST.TUMORI MILANO RF‐2011‐ 02351230 In vitro and in vivo antimicrobial activities of innovative and unconventional drug combinations to treat infections caused by multi‐drug‐resistant (MDR), extensively‐ drug‐resistant (XDR) or pandrug‐resistant (PDR) Acinetobacter baumannii and Pseudomonas RF‐2011‐ 02347944 RF‐2011‐ 02348225 Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 2 ‐ Translational Clinical Oncology 20 Risk, Prevention and Health Behavior Oncology 20 Biomedical Oncology 2 ‐ Translational Clinical Oncology 20 Campania Biomedical Infectious Diseases and Microbiology Infection and immunity 20 From microGIST to overt GIST: dissection of the molecular alterations underlying GIST malignant evolution C.R.O. AVIANO Biomedical Oncology 1 ‐ Basic Translational Oncology 20,25 Role of HIV‐1 infection on colorectal carcinoma onset and progression: development of novel therapeutic strategies ISS Biomedical AIDS and Related Research Oncology 20,25 Pagina 173 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350319 Effect of cognitive stimulation with computerized‐training (Rehacom) on cerebral metabolism evaluated by 18F‐FDG‐ PET in patients with mild cognitive impairment (MCI) Liguria RF‐2011‐ 02352457 A a case‐control record‐linkage study on occupational aspects of neurological diseases RF‐2011‐ 02350385 Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 20,25 ISS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 20,5 Estrogen, inflammation and cholesterol homeostasis: a "Bermuda Triangle" for CVD risk? Sicilia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 20,5 RF‐2011‐ 02350891 Discovery and validation of clinical biomarkers for lung neuroendocrine neoplasms from formalin‐fixed paraffin‐ embedded tissues Sardegna Biomedical Oncology 2 ‐ Translational Clinical Oncology 20,5 RF‐2011‐ 02347775 Mediterranean diet and gut microbiota: an operational agorithm to unveil food effects on healthy growth and disease control OSPEDALE BAMBINO GESU' Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Food safety and animal welfare 20,5 RF‐2011‐ 02347309 Ranking patient‐oriented outcome measures with evidence‐based criteria in brain tumor patients Veneto Oncology 2 ‐ Translational Clinical Oncology 20,5 RF‐2011‐ 02347821 Arterial and Venous thrombotic risk in women approaching ART procedures: evaluation of thrombophilia screening. ‐ A prospective cohort study. CASA SOLLIEVO SOFFERENZA Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 20,5 Clinical Biomedical Pagina 174 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349774 Treatment of extremely high lipoprotein(a) levels with LDL‐apheresis in young patients with documented cardiovascular disease: a proof of concept trial Toscana RF‐2011‐ 02349807 Occupational health risk in dynamic olfactometry. Risk assessment for workers in the olfactometric laboratory and establishment of safety procedures for the implementation of the European Standard method for determination of odour concentration. MAUGERI RF‐2011‐ 02351568 MicroRNA detections in Exhaled Breath Condensate and blood of Malignant Mesothelioma Patients and Healthy Subjects exposed to Asbestos. MAGGIORE RF‐2011‐ 02351390 Role of angiotensin‐converting enzyme inhibitors on cardioprotection against anticancer therapy‐induced cardiotoxicity: in vivo clinical evidences along with in vitro studies. I.E.O. RF‐2011‐ 02352828 Cost‐effectiveness of Transcatheter Aortic Piemonte Vale Implantation in high‐risk patients with severe aortic valve stenosis: a real world study in the Italian public health care system RF‐2011‐ 02349061 Growth factors and lipid mediators signalling: shared intracellular pathways regulating the complex and dynamic process of wound healing SAN GALLICANO Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 20,5 Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 20,5 Biomedical Oncology 1 ‐ Basic Translational Diseases of environmental origin, with reference also to the workplace 20,5 Clinical Oncology 2 ‐ Translational Clinical Oncology 20,5 Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 20,5 Cell Biology Metabolism disorders and cardiovascular disease 20,5 Biomedical Pagina 175 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352399 Prediction of childhood visceral adiposity and hypertension by body composition measurement in early life in premature and small for gestational age infants. RF‐2011‐ 02351653 STRATEGIES FOR THE CONTROL OF ISS SKIN INFECTIONS BY DRUG RESISTANT BACTERIA WITH NATURAL PRODUCTS. RF‐2011‐ 02351827 Human oncogenic risk from consumption of beef red meat RF‐2011‐ 02347444 Mechanisms underlying cognitive dysfunction and decline in Parkinson's disease and related disorders: brain damage, functional reorganization, and effects of BDNF polymorphisms. RF‐2011‐ 02350288 STRATEGIES TO DECREASE THE Emilia‐Romagna INCIDENCE OF INFECTIONS/COLONIZATIONS BY GRAM NEGATIVE MULTIDRUG‐RESISTANT BACTERIA IN INTENSIVE CARE UNITS. A PROSPECTIVE, MULTICENTER TRANDOMIZED STUDY. RF‐2011‐ 02348536 Role of Prostanoid Metabolism in Aortic Valve Calcification Veneto RF‐2011‐ 02348469 Phenotyping Cheyne‐Stokes respiration in heart‐failure patients: a first step towards effective individualized treatment MAUGERI Tipologia AREA STRATEGICA SCORE. Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 20,5 Biomedical Infectious Diseases and Microbiology Infection and immunity 20,5 CROB Biomedical Oncology 1 ‐ Basic Translational Food safety and animal welfare 20,5 DON GNOCCHI Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 20,5 Infectious Diseases and Microbiology Infection and immunity 20,5 Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 20,5 Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 20,5 BURLO GAROFALO Clinical Classificazione 1 Liv. Clinical Pagina 176 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347153 Nitrosation of drugs of abuse in human saliva at the acidic pH of the stomach: mechanism of transformation and evaluation of the associated carcinogenic risk. RF‐2011‐ 02350951 Antibody deficiency disorders as risk factors Emilia‐Romagna for gastric cancer RF‐2011‐ 02352644 Development and validation of a predictive model of mortality and hospitalization in patients with diabetes using administrative databases. Puglia RF‐2011‐ 02350660 Influence of adipose derived mesenchymal stem cells and adipocytes on residual cancer cells growth in tumor bed. AOU San Martino‐IST ‐ Genova RF‐2011‐ 02347074 Role of Toll‐like receptors in chemoresistance of chronic lymphocytic leukemia RF‐2011‐ 02350035 RF‐2011‐ 02347926 Tipologia AREA STRATEGICA SCORE. Oncology 1 ‐ Basic Translational Oncology 20,5 Clinical Immunology Oncology 20,5 Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 20,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 20,5 SAN RAFFAELE Milano Biomedical Oncology 1 ‐ Basic Translational Oncology 20,5 Dissecting SOX2 role in breast cancer progression: from the epithelial‐to‐ mesenchymal transition to metastasis onset PASCALE Biomedical Oncology 1 ‐ Basic Translational Oncology 20,5 Proposal of a methodological procedure for animal biomonitoring in contaminated areas IZS Lazio e della Toscana Biomedical Veterinary Food safety and animal welfare 20,5 ISS Biomedical Classificazione 1 Liv. Pagina 177 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02348632 Environmental, food related (mycotoxins) and genetic basis of Neural Tube Defects susceptibility n Italian and Sudanese populations. MEDEA Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Neurological diseases RF‐2011‐ 02349171 Relationship between 3D BCR structure, microenvironment and response to BCR inhibitors/4HPR, to design novel Chronic Lymphocytic Leukemia combination therapies. AOU San Martino‐IST ‐ Genova Biomedical Oncology 2 ‐ Translational Clinical Oncology RF‐2011‐ 02352813 Human Cardiac Stem Cell Therapy in Patients with Severe Heart Failure Undergoing LVAD Implantation. Lazio Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 21 RF‐2011‐ 02352114 miRNAs role in Longevity and their relation Sardegna to cancer survival Biomedical Biology of Development and Aging Oncology 21 RF‐2011‐ 02347830 AN EXTENSIVE STUDY ON EVOLUTION AND PROGNOSIS IN MONOCLONAL GAMMOPATHIES: THE ROLE OF IMMUNOPHENOTYPE, CYTOGENETICS AND HLC RATIO IN PC AND Pre‐PC SUBCLONAL COMPARTMENTS Piemonte Biomedical Oncology 2 ‐ Translational Clinical Oncology 21 RF‐2011‐ 02352303 GENOMIC AND PROTEOMIC STUDIES ON EARLY STAGE PULMONARY ADENOCARCINOMA: identification of pathogenesis markers relevant for cancer screening and personalized therapy. Abruzzo Biomedical Healthcare Delivery and Methodologies Oncology 21 AREA STRATEGICA SCORE. 20,5 20,75 Pagina 178 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350247 Human infection from exposure to norovirus (NoV): improving and harmonization of diagnostic techniques, correlation between clinical cases and contaminated food and assessment of dose‐ response IZS Venezie RF‐2011‐ 02350547 Neuroendocrine storm and postoperative depression in cardiac surgery Toscana RF‐2011‐ 02351768 A new scenario for ALS/FTD: genetic contribution in outlier phenotypes AOU San Martino‐IST ‐ Genova RF‐2011‐ 02351735 Project Title: Respiratory viral infections: evaluation of the clinical value of virological diagnosis and study of the role of innate immune response in determining increased severity RF‐2011‐ 02349931 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Infectious Diseases and Microbiology Food safety and animal welfare 21 Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 21 Biomedical Genes, Genomes and Genetics Neurological diseases 21 SPALLANZANI Biomedical Infectious Diseases and Microbiology Infection and immunity 21 New strategies for the eradication of HIV reservoirs Emilia‐Romagna Biomedical AIDS and Related Research Infection and immunity 21 RF‐2011‐ 02350339 Effects of repetitive transcranial magnetic stimulation after early stroke: a study in children and developing rats STELLA MARIS Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 21 RF‐2011‐ 02350327 Implementation of a next generation multigene test for prognostic stratification and tailored therapy in glioblastoma patients Emilia‐Romagna Biomedical Oncology 2 ‐ Translational Clinical Oncology 21 Clinical Pagina 179 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02346790 MOLECULAR EVENTS RESPONSIBLE FOR GALEAZZI MIGRATORY PLASTICITY AND INVADOPODIA FORMATION IN BONE METASTASIS FROM BREAST CARCINOMA Biomedical Oncology 1 ‐ Basic Translational Oncology 21 RF‐2011‐ 02351455 Identification and validation of new molecular targets in the treatment of EGFR‐ resistant NSCLC Campania Biomedical Oncology 2 ‐ Translational Clinical Oncology 21 RF‐2011‐ 02349396 New pathobiologic prognostic factors in colorectal cancers: the role of circulating tumor cells, mismatch repair system's competence, and tumor deposits in non metastatic rectal cancer. IST.TUMORI MILANO Clinical Digestive, Kidney and Urological Systems Oncology 21 RF‐2011‐ 02351342 CHEMOPREVENTIVE EFFICACY OF GREEN TEA EXTRACTS IN PROSTATE CANCER PROGRESSION. CLINICAL AND MOLECULAR STUDY ON MECHANISM OF ACTION SAN RAFFAELE Milano Clinical Oncology 2 ‐ Translational Clinical Oncology 21 RF‐2011‐ 02351897 Study of motor cortex electrical activity and neuroinflammatory hypothesis in ALS. SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 21 RF‐2011‐ 02351732 Omic and biosensor new approaches to detect hormonal growth promoters in food‐ producing animals IZS Mezzogiorno Biomedical Genes, Genomes and Genetics Food safety and animal welfare 21 RF‐2011‐ 02349454 The role of Integrin alpha5/beta1 as a Lazio potential therapeutic target in breast cancer bone metastasis Biomedical Oncology 2 ‐ Translational Clinical Oncology 21 AREA STRATEGICA SCORE. Pagina 180 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02351324 INTERACTION OF ACUTE MYELOID LEUKEMIA CELLS WITH NATURAL KILLER CELLS: BIOLOGICAL ASPECTS AND CLINICAL IMPLICATIONS Emilia‐Romagna Biomedical Oncology 2 ‐ Translational Clinical Oncology 21 RF‐2011‐ 02351223 Study of genetic variability oF HCV genotype 4 strains circulating in Lazio and analysis of their resistance pattern correlated to new DDA drug SPALLANZANI Biomedical Infectious Diseases and Microbiology Infection and immunity 21 RF‐2011‐ 02349741 Development of novel 'tailored' therapy in acute myeloid leukemia (AML) with NPM1 gene mutations Umbria Biomedical Oncology 2 ‐ Translational Clinical Oncology 21 RF‐2011‐ 02351581 Discovery and validation of circulating biomarkers for the early diagnosis, assessment of prognosis and response to treatments in primary liver tumors on cirrhosis Emilia‐Romagna Biomedical Oncology 2 ‐ Translational Clinical Oncology 21 RF‐2011‐ 02350567 Focus on incidence and diversity of intestinal methanogens and host‐gut microbiota metabolic interactions in healthy and diseased human groups. Piemonte Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 21 RF‐2011‐ 02351428 Surveillance on the use of oral anticoagulant drugs in patients with atrial fibrillation MAGGIORE Vascular and Hematology Metabolism disorders and cardiovascular disease 21 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 181 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02349834 Pilot study of a combination of an mTOR inhibitor (everolimus) and capecitabine administered with a metronomic schedulein patients undergoing liver transplantation for hepatocellular carcinoma at high risk of recurrence. Emilia‐Romagna Clinical Oncology 2 ‐ Translational Clinical Oncology 21 RF‐2011‐ 02349514 Transcranial Direct Current Stimulation Emilia‐Romagna combined with Speech Therapy in Acute and Chronic Post‐stroke Aphasic Patients: a double blind, sham‐controlled, randomized study Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 21 RF‐2011‐ 02347363 Potential relevance of non classical human leukocyte antigens (HLA)‐G and ‐E and gelatinases as markers of tumor invasion and progression and their association with Computed Tomography and Magnetic Resonance Imaging perfusion findings in patients with hig Emilia‐Romagna Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 21 RF‐2011‐ 02349510 GENOMIC CHARACTERISTICS OF REGULATORY T‐CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA: RELATIONSHIP TO CLINICAL OUTCOME AND POTENTIAL IMPLICATION FOR TREATMENT CROB Clinical Oncology 2 ‐ Translational Clinical Oncology 21 RF‐2011‐ 02347400 A role for the modulation of Rho GTPase signalling in the therapy of Fragile X syndrome ISS Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 21 RF‐2011‐ 02347576 Striatal cholinergic transmission as a target for therapeutic intervention in Tourette Syndrome SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 21 AREA STRATEGICA SCORE. Pagina 182 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350358 Inflammatory and oxidative stress biomarkers associated with carotid atherosclerotic disease progression: a multi‐ marker strategy to identify patients at risk of clinical events RF‐2011‐ 02350869 Decisions of health care management and NEUROLESI cost accounting in Neuroscience and Severe Acquired Brain Damage (SABD) RF‐2011‐ 02352239 Genome wide association study and heritability of recently proposed cardiovascular risk factors such as arterial stiffness, endothelial dysfunction, blood pressure variability and pulse pressure amplification in an isolated population living in Ogliastra RF‐2011‐ 02347051 Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 21 Clinical Healthcare Delivery and Methodologies Neurological diseases 21 Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 21 Tregs/Th17 Imbalance, Intrahepatic Emilia‐Romagna Cytokine Milieu and Immune Dysregulation in Autoimmune Hepatitis Biomedical Immunology Infection and immunity 21 RF‐2011‐ 02348735 Dysglicemia in hypertensive and I.N.R.C.A. normotensive adult and old subjects: role of glucocorticoids and Metallothioneins. From pathophysiology to cardiovascular risk prevention. Acronym: DYGAM‐AGE Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 21 RF‐2011‐ 02350914 Analytical and clinical validation of assays for PARP1/PAR related biomarkers. ONCOLOGICO DI BARI Biomedical Oncology 2 ‐ Translational Clinical Oncology 21 RF‐2011‐ 02351949 Continuity of care and health expenditure for children with complex needs or chronic health conditions Emilia‐Romagna Healthcare Delivery and Methodologies Oncology 21 ISS AUXOLOGICO Clinical Pagina 183 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349219 Proposal of an animal platform for assessing Friuli‐Venezia Giulia the tumoral cell response to anti‐angiogenic or cytotoxix antineoplastic agents based on multimodality molecular imaging: multiparametric assessment by optical imaging, microMagnetic Resonance Imaging, and micr RF‐2011‐ 02349657 Keratoconus and autoimmune thyroid disorders HUMANITAS RF‐2011‐ 02349902 Identification and comparison of stool and plasma microRNA signatures as colorectal cancer markers Piemonte RF‐2011‐ 02351178 Modulation of treatment of elderly patients C.R.O. AVIANO with Diffuse Large B‐cell Lymphoma guided by Comprehensive Geriatric Assessment combined with metabolomic investigations to identify specific patients frailty profiles predictive of treatment toxicity RF‐2011‐ 02347636 Development and standardization of biosensor‐based assays for the fast and sensitive detection of food‐borne bacteria in food IZS Mezzogiorno RF‐2011‐ 02350001 Effects of robotic‐aided rehabilitation on the wrist joint in hemiparetic patients: an fMRI study ISS Tipologia Biomedical Clinical Biomedical Clinical Biomedical Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 2 ‐ Translational Clinical Oncology Brain Disorders and Clinical Neuroscience Infection and immunity Oncology 1 ‐ Basic Translational Oncology 21,5 Oncology 2 ‐ Translational Clinical Oncology 21,5 Bioengineering Sciences and Technologies Food safety and animal welfare 21,5 Musculoskeletal, Oral and Skin Sciences Neurological diseases 21,5 21 21,25 Pagina 184 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349863 Effectiveness and costs‐effectiveness analysis of a caring model for hospitalized cancer patients with severe acute clinical problems Emilia‐Romagna Clinical Healthcare Delivery and Methodologies Oncology 21,5 RF‐2011‐ 02352243 Non‐invasive treatment of facet joint osteoarthritis low back pain by Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS): techniques and protocols optimization, clinical study and immune response assessment Sicilia Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 21,5 RF‐2011‐ 02349986 ICT for Quality Assurance and Advanced Information Management in Immunology and Oncology Biobanking: a Bridge Between Care and Research HUMANITAS Clinical Healthcare Delivery and Methodologies Infection and immunity 21,5 RF‐2011‐ 02349214 Activation‐Induced Cytidine Deaminase as Oncogenic Mutator in HCV‐related B‐cell Non‐Hodgkin¿s Lymphoma and Hepatocellular Carcinoma: A Single Cell‐ level Study. Puglia Biomedical Oncology 1 ‐ Basic Translational Oncology 21,5 RF‐2011‐ 02348314 Study on the interaction of polyomavirus JC Toscana (JCPyV) with stem cells‐derived lineages Biomedical Infectious Diseases and Microbiology Infection and immunity 21,5 RF‐2011‐ 02347229 Functional Immune Reconstitution Evaluation of Immune Senescence Process in HIV Mono‐infected and Co‐infected Patients Undergoing cART (FIRE Study) SPALLANZANI Biomedical AIDS and Related Research Infection and immunity 21,5 RF‐2011‐ 02349447 Coronary Arteriogenesis with combined Heparin and EXercise therapy in Chronic refractory Angina (CARHEXA study) Toscana Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 21,5 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 185 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02348311 IMPACT OF COMPUTERIZED PRESCRIPTION ON COMPLIANCE WITH GUIDELINES‐RECOMMENDED PROCESS IN PNEUMONIA. A STUDY TO ANALYZE A BETTER CONTROL OF ANTIBIOTIC THERAPY. Emilia‐Romagna RF‐2011‐ 02348452 Study of the role played by the Na+‐Ca2+ exchanger 1 (NCX1) for the development of the cardiac damage to bacterial infections causing hypertrophic heart response Marche RF‐2011‐ 02350600 Validation of Reticulocalbin 1 (RCN‐1) as a new marker for renal cell carcinoma (RCC) in a large retrospective study by IHC and regulation analysis of protein expression. Piemonte RF‐2011‐ 02350457 Multiplatform approach to dissect Wilms tumor heterogeneity IST.TUMORI MILANO RF‐2011‐ 02350917 CANCER IN IMMUNOCOMPROMISED POPULATIONS, HIV‐INFECTED (HIV) PATIENTS, ORGAN TRASPLANT RECIPIENTS (OTRs) and HIV‐OTRs: NEW PREVENTIVE and TREATMENT STRATEGIES FOR SOLID TUMOURS C.R.O. AVIANO RF‐2011‐ 02350550 Role of hypothermia in organ dysfunction after cardiac arrest Sicilia Biomedical RF‐2011‐ 02350661 Risk assessment of patients and medical operators in diagnostic and therapeutic cancer procedures: clinical, chemical, physical and humanization aspects Sicilia Clinical Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Healthcare Delivery and Methodologies Infection and immunity 21,5 Cardiovascular and Respiratory Sciences Infection and immunity 21,5 Clinical Oncology 2 ‐ Translational Clinical Oncology 21,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 21,5 Clinical Oncology 2 ‐ Translational Clinical Oncology 21,5 Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 21,5 Healthcare Delivery and Methodologies Oncology 21,5 Biomedical Pagina 186 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351846 Use of amiodarone and derivatives for treatment/prophylaxis of viral hemorragic fevers. Veneto Biomedical Infectious Diseases and Microbiology Infection and immunity 21,5 RF‐2011‐ 02346888 Analysis of cardiomyopathies and arrhythmogenic syndromes associated with high risk of sudden death: an integrated approach of functional genomics and clinical‐instrumental parameters. Puglia Biomedical Cardiovascular and Respiratory Sciences The new biotechnologies 21,5 RF‐2011‐ 02350788 Prognostic and predictive potential of miRNA signatures linking cancer to inflammatory and fibrotic diseases SAN MATTEO Biomedical Oncology 1 ‐ Basic Translational Oncology 21,5 RF‐2011‐ 02352866 Early detection of neurodegenerative diseases. The case of Alzheimer's disease Liguria Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 21,5 RF‐2011‐ 02350851 Development of innovative methods for radiobiological optimization of molecular radiotherapy treatments I.E.O. Clinical Bioengineering Sciences and Technologies The new biotechnologies 21,5 RF‐2011‐ 02352895 INNOVATIVE THERAPY FOR Lazio OSTEOARTHRITIS: FROM CLASSICAL VISCOINDUCTION TO INTRA‐ ARTICULAR INFILTRATION OF MULTILAYERED HYALURONIC ACID AND CHITOSAN MICROCAPSULES FOR PRECISE POINT OF CARE DELIVERY AND CONTROLLED RELEASE PROFILE Clinical Bioengineering Sciences and Technologies The new biotechnologies 21,5 RF‐2011‐ 02350632 Comprehensive evaluation of the potential of engineered nanoparticles to induce bronchial hyperreactivity in exposed workers. Biomedical Bioengineering Sciences and Technologies Diseases of environmental origin, with reference also to the workplace 21,5 Lazio Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 187 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02352493 MULTICENTER, RANDOMIZED, CLINICAL TRIAL ON THE COMPARISON BETWEEN EARLY SURGERY AND CONVENTIONAL THERAPY IN INFECTIVE ENDOCARDITIS. THE EARLY STUDY. Piemonte Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 21,5 RF‐2011‐ 02352002 Enabling assessment of attention and motivation during post‐stroke robot‐ assisted rehabilitation to improve patient adherence to treatment and outcome. MAUGERI Clinical Musculoskeletal, Oral and Skin Sciences Neurological diseases 21,5 RF‐2011‐ 02350383 Development of a cheap point‐of‐care assay for molecular diagnosis of legionellosis ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 21,5 RF‐2011‐ 02347473 Nanotechnology for the delivery of Zoledronic Acid: a new opportunity against cancer REGINA ELENA Biomedical Oncology 2 ‐ Translational Clinical Oncology 21,5 RF‐2011‐ 02351383 Safety of general anaesthesia (GA) in neonatal and pediatric age: neurotoxicity of drugs as revealed by neuropsychological indexes and biomarkers Emilia‐Romagna Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 21,5 RF‐2011‐ 02352437 QOLIBRI ‐ Quality of Life after Brain Injury: the new challenge for tomorrow SANTA LUCIA Biomedical Risk, Prevention and Health Behavior Neurological diseases 21,5 RF‐2011‐ 02352329 Role of bilateral STN DBS on impulse control disorders and related behaviors in Parkinson's disease: a quasi‐experimental clinical trial CARLO BESTA Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 21,75 AREA STRATEGICA SCORE. Pagina 188 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351635 Antibiotic resistant bacteria and ready to eat salads: are they really ready to be consumed? IZS Mezzogiorno RF‐2011‐ 02349728 Measured physiological and psycological outcomes with hypnotic behavioral adjuncts as an experimental tool in laboratories of interventional cardiac procedures Piemonte RF‐2011‐ 02351295 biomarkers characterization in the glatiramer acetate therapy of relapsing multiple sclerosis RF‐2011‐ 02346830 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Veterinary Food safety and animal welfare 21,75 Clinical Biobehavioral and Behavioral Processes Metabolism disorders and cardiovascular disease 21,75 Puglia Biomedical Emerging Technologies and Training in Neurosciences Neurological diseases 21,75 Cyclodextrin cross‐linking ‐ nanosponges (CD‐NS) for melanoma‐targeted drug delivery Piemonte Biomedical Bioengineering Sciences and Technologies The new biotechnologies 22 RF‐2011‐ 02350257 Antimicrobial peptide‐based nanotherapeutics to prevent biofilm formation or to eradicate pre‐formed biofilms associated with catheter‐related, antibiotic resistant nosocomial infections Toscana Biomedical Bioengineering Sciences and Technologies Infection and immunity 22 RF‐2011‐ 02352171 Genetic, molecular and bioinformatics approaches for early detection of HIV‐ associated neurocognitive disorders (BioHAND Study) Puglia Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 22 RF‐2011‐ 02346751 The subcutaneous immunoglobulins as first‐ Piemonte line therapy of chronic inflammatory neuropathies. A pilot study. Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 22 Pagina 189 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352374 Innovative Nanomedicines for the Efficacious Treatment of Dogs affected by Leishmaniasis IZS Sicilia Biomedical Veterinary Food safety and animal welfare 22 RF‐2011‐ 02349199 CANCER RISK EVALUATION IN A COHORT OF FARMERS EXPOSED TO ZOONOTIC AGENTS IZS Sicilia Biomedical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 22 RF‐2011‐ 02352712 Clinical and Economical Impact of a Multiplex PCR‐Based Assay for a rapid Detection of Pathogens Causing Sepsis in non‐hospitalized onco‐hematological Patients with neutropenic fever SAN RAFFAELE Milano Clinical Infectious Diseases and Microbiology Infection and immunity 22 RF‐2011‐ 02349692 Point‐of‐care lung ultrasonography in the bedside evaluation of patients in the critical care and emergency settings Piemonte Clinical Cardiovascular and Respiratory Sciences The new biotechnologies 22 RF‐2011‐ 02347193 Characterization of human amniotic mesenchymal stem cells (hA‐MSCs) isolated from obese women at deliveryto identify gene or protein alterations predisposing the newborn to obesity. SDN Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 22 RF‐2011‐ 02352267 Strategies To Improve Human Cardiac Stem Lazio Cell Regenerative Capacity In Patients With Post‐Ischemic Left Ventricular Remodelling Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 22 RF‐2011‐ 02350353 Genetic, immunologic and viral determinants of HIV‐1 disease progression Biomedical AIDS and Related Research Infection and immunity 22 Lombardia Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 190 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02352275 Nanomaterials‐based diagnostic devices for melanoma I.E.O. Clinical Bioengineering Sciences and Technologies Oncology 22 RF‐2011‐ 02351799 Cerebral blood flow velocity in children with sickle cell disease before and after adenotonsillectomy Emilia‐Romagna Clinical Cardiovascular and Respiratory Sciences Neurological diseases 22 RF‐2011‐ 02348343 CHILDHOOD HISTIOCYTOSES: FROM PATHOGENESIS TO TARGET THERAPY ‐ "HISTIOCARE" Toscana Biomedical Immunology Infection and immunity 22 RF‐2011‐ 02352215 Inflammatory bowel diseases and environmental stressors: a system biology approach Campania Biomedical Digestive, Kidney and Urological Systems Diseases of environmental origin, with reference also to the workplace 22 RF‐2011‐ 02347100 EFFECTS OF PERIPHERALLY ADMINISTERED BDNF IN THE R6/2 MOUSE MODEL OF HUNTINGTON¿S DISEASE SANTA LUCIA Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 22 RF‐2011‐ 02352448 Humanization of Emergency Departments in Hospitals: new features and patient satisfaction for chronic metabolic and cardiovascular diseases Piemonte Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 22 RF‐2011‐ 02350451 Role of deubiquitinases in resistance to treatment of ovarian carcinoma IST.TUMORI MILANO Biomedical Oncology 2 ‐ Translational Clinical Oncology 22 RF‐2011‐ 02352271 Search for cancer‐specific proteomic biomarkers in exosomes and red blood cells to rule out lung cancer risk in suspicious incidental nodules detected by imaging techniques Veneto Biomedical Oncology 2 ‐ Translational Clinical Oncology 22 Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 191 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350225 IDENTIFICATION OF NEW STRAINS OF POTENTIALLY PROBIOTIC BACTERIA FROM HUMAN FECES AND FOODS: SUBSEQUENT INVESTIGATION OF THEIR ACTIVITY ON THE BROKERS OF THE SYSTEMIC AND INNATE IMMUNE SYSTEM. POSSIBLE USE OF THE ISOLATE STRAINS ALSO AS DELIVERY SYSTEM FOR Emilia‐Romagna Biomedical Immunology Infection and immunity 22 RF‐2011‐ 02350511 Realization of a database of clinical data for improving the outcome of the univentricular heart patient ISS Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 22 RF‐2011‐ 02351958 Prematurity and low weight at birth as new conditions predisposing to an increased cardiovascular risk. A human study by means of metabolomics, instrumental cardiology, endothelial progenitor cells evaluation, paralleled by an animal experimental model. Sardegna Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 22 RF‐2011‐ 02348570 Role of CREB protein family members in human lymphoid malignancies Abruzzo Biomedical Cell Biology Oncology 22 RF‐2011‐ 02348616 Maternal exposure to ENMs: a Lazio comprehensive study of feto‐placental effects as a function of developmental stage. Biomedical Bioengineering Sciences and Technologies Diseases of environmental origin, with reference also to the workplace 22,25 RF‐2011‐ 02350727 Molecular determinants of malignancy, invasiveness and response to therapy of Oro‐pharyngeal squamous cell carcinomas. A molecular and Redox proteomics compaative analysis of HPV positive and HPV negative invasive tumours. Biomedical Oncology 1 ‐ Basic Translational Oncology 22,25 REGINA ELENA Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 192 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02350421 Restoring innate immunity by in vivo gene editing: Development of novel approaches to correct abnormal cilia motility in the respiratory airways and cure the primary ciliary dyskinesia in pediatric patients Toscana Biomedical Genes, Genomes and Genetics Infection and immunity 22,25 RF‐2011‐ 02352603 SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) BASED DIAGNOSTIC KIT DEVELOPMENT FOR LEUKEMIA BIOMARKER DETECTION SAN RAFFAELE Milano Biomedical Bioengineering Sciences and Technologies The new biotechnologies 22,5 RF‐2011‐ 02352734 A MULTIMODALITY APPROACH TO PREVENT POSTOPERATIVE NEUROLOGICAL DYSFUNCTION IN PATIENTS UNDERGOING CARDIAC SURGERY Veneto Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 22,5 RF‐2011‐ 02350763 Identification of molecular signature in thyroid carcinoma to improve Fine Needle Aspiration Biopsy Accuracy Sicilia Oncology 2 ‐ Translational Clinical Oncology 22,5 RF‐2011‐ 02346918 Influence of Zinc transporters on glycemic control and cardiovascular risk prevention I.N.R.C.A. Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 22,5 RF‐2011‐ 02350430 Creation and Preclinical validation of stem cell‐functionalized bio‐substitutes for oral bone defects treatment Piemonte Biomedical Bioengineering Sciences and Technologies The new biotechnologies 22,5 RF‐2011‐ 02350465 Renal stress Echo: a new non invasive non ionizing imaging tool to assess renal sympathetic activity in arterial hypertension and cardiometabolic disease Toscana Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 22,5 Biomedical Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 193 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350444 Role of maternal intrapartum antibiotic prophylaxis on neonatal gut microbiota flora and onset of later allergy related diseases Lombardia RF‐2011‐ 02351129 Process modelling as a tool to support integrated care pathway implementation in lung cancerpatients. Friuli‐Venezia Giulia RF‐2011‐ 02347458 Cardiopulmonary risk and Transplantation Campania RF‐2011‐ 02347055 Study of orphan muscle diseases with an SAN RAFFAELE Milano inflammatory component and identification of novel therapeutic molecules. RF‐2011‐ 02349978 Regulatory and effector T cell populations count during chronic graft versus host disease and extracorporeal photopheresis (ECP): flow cytometric cGVHD activity monitoring. RF‐2011‐ 02350734 A mathematical‐experimental model of ARCISPEDALE‐Reggio beta‐amyloid diffusion in Alzheimer disease Emilia and its application to early diagnosis RF‐2011‐ 02351275 Identification of biological markers as predictors of brain plasticity and indicators of the efficacy of rehabilitation in post‐ stroke patients Lazio AUXOLOGICO Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Immunology Infection and immunity 22,5 Clinical Healthcare Delivery and Methodologies Oncology 22,5 Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 22,5 Biomedical Musculoskeletal, Oral and Skin Sciences Infection and immunity 22,5 Clinical Immunology Oncology 22,5 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 22,5 Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 22,5 Pagina 194 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02349430 Epithelial ovarian cancer: management of advanced stage disease recurrence by an (epi)genomic‐driven approach IST.TUMORI MILANO RF‐2011‐ 02348171 Characterization of the microbiome of natural and invasive vector mosquito populations through next‐generation sequencing IZS Venezie RF‐2011‐ 02349335 SEEKING MOLECULAR BIOMARKERS OF CERVICAL INTRAEPITHELIAL NEOPLASIA PROGRESSION BY MICROARRAY ANALYSIS OF CLONAL CIN3 KERATINOCYTES. Emilia‐Romagna RF‐2011‐ 02351470 Health Care Professionals as Second Victims After Adverse Events Marche RF‐2011‐ 02348299 NEW ANTIFUNGAL THERAPEUTIC STRATEGIES IN NANOMEDICINE ISS RF‐2011‐ 02348071 INNOVATIVE EPINEPHRINE (ADRENALINE) FORMULATIONS WITH IMPROVED STABILITY FOR USE IN EMERGENCY SITUATIONS RF‐2011‐ 02352174 RF‐2011‐ 02348217 Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 2 ‐ Translational Clinical Oncology 22,5 Biomedical Infectious Diseases and Microbiology The new biotechnologies 22,5 Biomedical Oncology 2 ‐ Translational Clinical The new biotechnologies 22,5 Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 22,5 Biomedical Infectious Diseases and Microbiology Infection and immunity 22,5 SAN MATTEO Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 22,5 MicroRNA profile in plasma and sputum in the low‐dose CT lung cancer screening trial Italung Toscana Biomedical Oncology 2 ‐ Translational Clinical Oncology 22,5 Health and Economic Impact of Tobacco Control Policies in Italy Toscana Biomedical Risk, Prevention and Health Behavior Oncology 22,5 Clinical Pagina 195 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349186 Evaluation of potential presence of heavy metals and nanoparticles in fishes and baby foods IZS Sicilia RF‐2011‐ 02352238 Development of a Regional network for the improvement of the operators compliance to the management of the Italian Register of Oncologic Drugs (RFOM) of Italian Medicines Agency (AIFA) Toscana Clinical RF‐2011‐ 02352133 Evaluation of the molecular mechanisms and therapeutic efficacy of a new NGF mimetic compound with anti‐apoptotic activity in cardiac and cerebral ischemia/reperfusion (I/R) Toscana Biomedical RF‐2011‐ 02348857 ACG4GEO: Integration between "Adjusted Clinical Group" system and Geomedicine for a new vision about the environment health and personal health Veneto RF‐2011‐ 02351207 Clinical and genetic study of the predisposition to Renal Cancer in women affected by uterine fibroids and families with Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome RF‐2011‐ 02348991 Age‐immunological profile of stable kidney allograft patients as a key to modulate the immunosuppressive therapy Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Risk, Prevention and Health Behavior Food safety and animal welfare 22,5 Healthcare Delivery and Methodologies Oncology 22,5 Brain Disorders and Clinical Neuroscience Metabolism disorders and cardiovascular disease 22,5 Clinical Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 22,5 Lazio Clinical Oncology 2 ‐ Translational Clinical Oncology 22,5 Piemonte Clinical Immunology Infection and immunity 22,5 Pagina 196 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351250 Prevention of chronic kidney disease (CKD) progression by hypoxia‐inducible‐prolyl‐ hydroxylases (HIF‐PHs) inhibition: role of SIRT1 and autophagy MAUGERI RF‐2011‐ 02349666 Attention to memory: mechanisms of competition during memory retrieval in mild cognitive impairment SANTA LUCIA RF‐2011‐ 02352688 IDENTIFICATION OF THE GENETIC BACKGROUND ASSOCIATED TO THE IMPAIRMENT OF RENAL TUBULAR INTRACELLULAR MACHINERY FOR ENDOCYTOSED PROTEINS. SELECTION OF NOVEL BIOMARKERS PREDICTING ONSET OR PRGRESSION OF CHRONIC RENAL FAILURE. RF‐2011‐ 02350877 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Digestive, Kidney and Urological Systems The new biotechnologies 22,5 Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 22,5 Veneto Biomedical Genes, Genomes and Genetics The new biotechnologies 22,75 Economic Impact of Target Agents and their Side Effects Piemonte Biomedical Oncology 2 ‐ Translational Clinical Oncology 22,75 RF‐2011‐ 02351910 Physical Activity prevents the Cognitive Impairment in the Metabolic Syndrome (PACIMeS) SANTA LUCIA Biomedical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease 23 RF‐2011‐ 02351189 Multidisciplinary Intervention Protocol in metabolic emergencies in Anorexia Nervosa Emilia‐Romagna Clinical Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 23 RF‐2011‐ 02350312 Prospective study of molecular prognostic and predictive factors and pharmacokinetic analysis in patients with Gastrointestinal Stromal Tumor treated with targhet therapy Toscana Clinical Oncology 2 ‐ Translational Clinical Oncology 23 Pagina 197 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351002 Molecular profiling of adult Acute Lymphoblastic Leukemia for risk stratification and treatment definition Lombardia RF‐2011‐ 02349965 Ectopic calcifications: from molecular mechanisms towards therapeutic perspectives Emilia‐Romagna RF‐2011‐ 02347947 Impact of early high‐dose atorvastatin versus rosuvastatin on Contrast Induced Acute Kidney Injury in unselected patients with non‐ ST elevation acute coronary syndromes scheduled for early invasive strategy Toscana RF‐2011‐ 02348619 The impact of the Directive 2010/63/EU on Italian research activities and welfare of animals ISS RF‐2011‐ 02350861 Gender effect on the pleiotropic actions of statins on lipoproteins and platelets from elderly women affected by Type 2 diabetes mellitus I.N.R.C.A. RF‐2011‐ 02348791 Role of functional and morphological MRI in the study of thalamus and auditory cortex for the assessment ofthe neurocognitive and clinical outcomes of premature newborns SAN RAFFAELE Milano RF‐2011‐ 02352434 Disability diseases related: (Di.di.re) ICF as tools to weight disability in rehabilitation SAN RAFFAELE Pisana‐ Roma Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 2 ‐ Translational Clinical Oncology 23 Vascular and Hematology Metabolism disorders and cardiovascular disease 23 Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 23 Biomedical Veterinary Food safety and animal welfare 23 Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 23 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 23 Clinical Healthcare Delivery and Methodologies Neurological diseases 23 Biomedical Clinical Pagina 198 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02352147 Empower through Communication: a Generative Model for Health‐Care Organizations RF‐2011‐ 02349115 DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Clinical Healthcare Delivery and Methodologies Neurological diseases 23 Biological and therapeutical significance of IST.TUMORI MILANO androgen receptor expression in salivary gland cancers (SGCs): a translation research in a randomized, international, phase II study to evaluate the efficacy of chemotherapy versus androgen deprivation therapy Clinical Oncology 2 ‐ Translational Clinical Oncology 23 RF‐2011‐ 02352262 Improving reading and behavioural control in dyslexia and ADHD with training on executive functions OSPEDALE BAMBINO GESU' Clinical Biobehavioral and Behavioral Processes Neurological diseases 23 RF‐2011‐ 02352148 Optimal duration of treatment and optimal management of thromboembolic events in cancer patients (Morgagni‐Cancer Study) ARCISPEDALE‐Reggio Emilia Clinical Vascular and Hematology Oncology 23 RF‐2011‐ 02351224 Sexual function in epileptic male patients NEUROLESI Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 23 RF‐2011‐ 02352419 Novel Clinical and Molecular Determinants of Glucocorticoid Response in Obesity‐ related Asthma Campania Biomedical Cardiovascular and Respiratory Sciences Infection and immunity 23 RF‐2011‐ 02350950 Development of a model for quantitative risk assessment of tick‐borne diseases in Italian urban parks ISS Biomedical Infectious Diseases and Microbiology Infection and immunity 23 RF‐2011‐ 02348015 Ethics in Cancer Care: a new service I.E.O. Clinical Healthcare Delivery and Methodologies Oncology 23 NEUROLESI Pagina 199 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02348712 Pregnancy complication in transplanted women: anti‐phospholipids antibodies as sensitive biomarkers of prognostic value and pathogenetic determinants. ISS Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Infection and immunity RF‐2011‐ 02348514 Hypoxia and MicroRNAs in the Regulation of the Dystrophin‐associated Protein Complex: Implications for Cognitive Deficits in Duchenne Muscular Dystrophy ISS Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 23,25 RF‐2011‐ 02347575 Update, integration and implementation of the Italian Respiratory Risk Charts Toscana Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 23,25 RF‐2011‐ 02351887 Clinical and genetic new tools for Autosomal Dominant Polycystic Kidney Disease diagnosis Emilia‐Romagna Clinical Digestive, Kidney and Urological Systems The new biotechnologies 23,5 RF‐2011‐ 02352332 Identification and validation of biomarkers Veneto in saliva and scraping of buccal cells for the early detection of oral lesions at risk of developing cancer Biomedical Oncology 2 ‐ Translational Clinical Oncology 23,5 RF‐2011‐ 02350562 Identification of immune correlates of clinical activity and/or disease outcome in melanoma and mesothelioma patients undergoing immunotherapy or targeted therapy Toscana Clinical Oncology 2 ‐ Translational Clinical Oncology 23,5 RF‐2011‐ 02347259 STUDY ON THE POTENTIAL USE OF COMBRETUM MICRANTHUM AS AN ANTITUMOR AND CHEMOPREVENTIVE AGENT. AOU San Martino‐IST ‐ Genova Biomedical Oncology 2 ‐ Translational Clinical Oncology 23,5 AREA STRATEGICA SCORE. 23 Pagina 200 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352339 Understanding sirtuin specificity and IDI identification of selective therapeutics using a trans‐kingdom approach RF‐2011‐ 02349611 Integrated lipidomic profiling in diabetes and cardiovascular disease in a cohort of subjects in a mediterranean area of southern Italy: a nested case control study RF‐2011‐ 02349672 Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Genes, Genomes and Genetics Metabolism disorders and cardiovascular disease 23,5 DE BELLIS Biomedical Biological Chemistry and Macromolecular Biophysics Metabolism disorders and cardiovascular disease 23,5 Development and validation of a personal dosimeter for the exposure to electromagnetic fields of Magnetic Resonance healthcare personnel Toscana Biomedical Bioengineering Sciences and Technologies The new biotechnologies 23,5 RF‐2011‐ 02347335 Innovative analytical methods for determination of veterinary drug residues in foodstuffs IZS Umbria e delle Marche Biomedical Veterinary Food safety and animal welfare 23,5 RF‐2011‐ 02351538 The Mitochondrial culprit in Amyotrophic Lateral Sclerosis: unravelling a novel molecular pathway to regulate VDAC1 in the disease's etiology SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 23,5 RF‐2011‐ 02350267 Improving the prognosis of melanoma patients through the use of new metastatic markers associated to the Notch pathway. Lombardia Biomedical Oncology 1 ‐ Basic Translational Oncology 23,5 Pagina 201 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02352639 Implementation of a network on the use of Human Biomonitoring Data in Environmental Epidemiology (HumanBioEnvEpi: HBEE‐ ITA)Realizzazione di una rete sull¿uso nell¿epidemiologia ambientale dei dati del biomonitoraggio umano (HumanBioEnvEpi: HBEE‐ITA) Piemonte Clinical RF‐2011‐ 02350244 Occupational and environmental exposure to dangerous chemicals and reproductive pathologies Campania RF‐2011‐ 02351311 Cytokine profile in ocular surface diseases and upper airways disorders: development of medical devices for ophthalmology and otorhinolaryngology use. Sicilia RF‐2011‐ 02348939 The Development and progression of breast C.R.O. AVIANO cancer: when microRNAs fail to inhibit EMT and stemness. RF‐2011‐ 02352896 Work‐oriented upper extremity functional evaluation: development of an integrated measurement platform for identification of return‐to‐work strategies Toscana RF‐2011‐ 02347019 Telemonitoring in long‐term ventilator‐ dependent patients: a multicenter randomized controlled study Toscana RF‐2011‐ 02346746 Extracorporeal Shock Waves (ESW) as a tool in stem cell‐based procedures for cartilage and tendon regeneration Piemonte Classificazione 1 Liv. AREA STRATEGICA SCORE. Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 23,5 Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diseases of environmental origin, with reference also to the workplace 23,5 Clinical Brain Disorders and Clinical Neuroscience Diseases of environmental origin, with reference also to the workplace 23,5 Oncology 1 ‐ Basic Translational Oncology 23,5 Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering Diseases of environmental origin, with reference also to the workplace 23,5 Clinical Cardiovascular and Respiratory Sciences Neurological diseases 23,5 Bioengineering Sciences and Technologies The new biotechnologies 23,5 Biomedical Biomedical Pagina 202 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02346933 Identification and use of markers of RIZZOLI exposure and effect on decision‐making in patients with metal‐on‐metal joint implants Biomedical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace RF‐2011‐ 02347808 Ex vivo studies on hyperhomocysteinemia‐ induced epigenetic modifications as potential biomarkers for early diagnosis of cerebrovascular disorders. Sardegna Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 23,75 RF‐2011‐ 02347984 Biomolecular networks contributing to cancer risk in dysmetabolic disorders: implications for type 2 diabetes and obesity SAN RAFFAELE Pisana‐ Roma Biomedical Oncology 2 ‐ Translational Clinical Metabolism disorders and cardiovascular disease 23,75 RF‐2011‐ 02349526 Effective and genetically‐driven bio‐clinical road map defining tailored, multidisciplinary, treatment strategies of metastatic colorectal cancer (MCRC) patients. Abruzzo Biomedical Oncology 2 ‐ Translational Clinical Oncology 23,75 RF‐2011‐ 02352211 CHARACTERIZATION OF BIOMARKERS FOR CARDIOVASCULAR DISEASES AT EARLY PRESENTATION Veneto Biomedical Biological Chemistry and Macromolecular Biophysics Metabolism disorders and cardiovascular disease 23,75 RF‐2011‐ 02351881 Identification of novel biomarkers of recurrence in locally advanced cervical cancer REGINA ELENA Oncology 2 ‐ Translational Clinical Oncology 24 RF‐2011‐ 02346929 Genetic and environmental factors underlying metabolic inflexibility and their impact for the prevention and treatment of obesity: basic and clinical studies ISS Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 24 Clinical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. 23,5 Pagina 203 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02348702 GENE EXPRESSION PROFILE AT THE ONSET OF SEVERE CARDIAC FAILURE: IDENTIFICATION AND VALIDATION OF NEW BIOMARKERS GASLINI Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 24 RF‐2011‐ 02352767 Angiogenic pattern as early marker of colon cancer progression. A morphological and immunohistochemical study on colorectal adenomas according to modality of detection. Toscana Biomedical Oncology 1 ‐ Basic Translational Oncology 24 RF‐2011‐ 02351490 THE USE OF SENTINEL ANIMALS TO EVALUATE THE ROLE OF ENVIRONMENTAL CHEMICAL POLLUTION IN YOUNG WOMEN WITH BREAST CANCER LIVING IN SINs (NATIONAL iNTEREST SITES) IZS Mezzogiorno Biomedical Veterinary Food safety and animal welfare 24 RF‐2011‐ 02350789 Biomolecular and Biosensor innovative approaches to guarantee Protected Designation of Origin (PDO) Water Buffalo Mozzarella Cheese IZS Mezzogiorno Biomedical Veterinary Food safety and animal welfare 24 RF‐2011‐ 02350597 Viral infections and related neurological and intestinal damages as possible factors triggering autism spectrum disorders Campania Brain Disorders and Clinical Neuroscience Infection and immunity 24 RF‐2011‐ 02349502 Neuronal lifespan in longer living brains SAN MATTEO Biology of Development and Aging Neurological diseases 24 Clinical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 204 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351962 CLINICAL AND ADMINISTRATIVE WORKLOAD: PHYSICIANS WELLBEING, PERFORMANCE AND CONSEQUENCES ON PATIENT SAFETY. COMPARATIVE ANALYSIS AMONG THREE IMPORTANT ACUTE ITALIAN HOSPITALS Toscana Clinical RF‐2011‐ 02348247 Epigenetic modulation by asbestos exposure in asbestos‐related cancers:identification of epigenetic biomarkers to predict asbestos‐related malignancies. Marche Biomedical RF‐2011‐ 02352297 STRATEGIES TO PROMOTE THE CONTINUOUS IMPROVEMENT OF PATIENT SAFETY AND QUALITY IN HEALTH CARE Campania RF‐2011‐ 02351310 Ultimate and stable healing of chronic ulcers of the lower limbs with long lasting patient recovery: a great achievement of dramatic social impact with minimal financial commitment. AOU San Martino‐IST ‐ Genova RF‐2011‐ 02352167 HELP (Hepatitis and HIV Emergencies, Life Campania & protection Program for drug addicts and immigrants wide range information) RF‐2011‐ 02347601 HIV‐ infected mesenchimal stem cell differentiation: miRNA expression profile and role of antiretroviral therapy Lombardia Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 24 Oncology 2 ‐ Translational Clinical Oncology 24 Clinical Healthcare Delivery and Methodologies Infection and immunity 24 Clinical Musculoskeletal, Oral and Skin Sciences Metabolism disorders and cardiovascular disease 24 Clinical Infectious Diseases and Microbiology Infection and immunity 24 AIDS and Related Research Infection and immunity 24 Biomedical Pagina 205 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352333 Synthesis of new compounds with antiRET activity and evaluation of their anti‐ neoplastic activity (in vitro and in vivo) in papillary and medullary thyroid cancer Toscana RF‐2011‐ 02347524 Novel tools for immune monitoring and immune reconstitution in children with severely compromised T‐lymphocyte responses associated with hemato‐ oncological diseases. OSPEDALE BAMBINO GESU' RF‐2011‐ 02350189 Potential Role of blood miRNA as non invasive biomarkers for early detection of stroke and hemorrhagic transformation RF‐2011‐ 02347521 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 2 ‐ Translational Clinical Oncology 24 Clinical Immunology Infection and immunity 24 Sicilia Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 24 DEVELOPMENT AND VALIDATION OF A COMORBIDITY INDEX SPECIFIC FOR STROKE PATIENTS Emilia‐Romagna Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 24 RF‐2011‐ 02347915 ASSESSMENT OF PSYCHO‐PHYSICAL RESPONSE TO STRESSORS IN WORK ENVIRONMENT. RESEARCH OF CHANGES IN HEALTH PROFESSIONALS AS A RESULT OF PARTICIPATION IN A GROUP EXPERIENCE ON STRESS MANAGEMENT AND INTERPERSONAL COMMUNICATION. I.N.R.C.A. Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 24 RF‐2011‐ 02350130 Prescription of Physical Activity to prevent the onset of type 2 diabetes Veneto Clinical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease 24 Pagina 206 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02347832 Effectiveness of repeated immunizations with DNA plasmids encoding HER‐2/neu in the long‐term prevention of mammary cancer in HER‐2/neu transgenic mice I.N.R.C.A. Biomedical Biology of Development and Aging Oncology 24 RF‐2011‐ 02351175 A simple set of tools for large‐scale multi‐ parametric screening of sensory‐motor functions of the cervico‐cranial area. A combined longitudinal and cross‐sectional study in 4‐14 years old children Piemonte Biomedical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 24 RF‐2011‐ 02351350 Reduced aspirin action in preventing cardiovascular events in diabetic patients: molecular and cellular studies on megakaryocyte progenitor cells and platelets. ISS Biomedical Vascular and Hematology Metabolism disorders and cardiovascular disease 24 RF‐2011‐ 02349940 Risk stratification of hospital‐acquired infection, an Artificial Neural Network approach Piemonte Clinical Risk, Prevention and Health Behavior Infection and immunity 24 RF‐2011‐ 02351403 Can we predict the cognitive status in mild cognitive impairment (MCI) subjects who had a traumatic brain injury (TBI) basing on neurophysiological and biological markers? SAN RAFFAELE Pisana‐ Roma Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 24,25 RF‐2011‐ 02348748 Identification of immunologic and vascular biomarkers of disease progression or remission in autoimmune disorders for the clinical management and therapeutic monitoring SAN GALLICANO Clinical Immunology Infection and immunity 24,25 AREA STRATEGICA SCORE. Pagina 207 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351123 Comprehensive diagnostic and rehabilitation tools in the assessment and treatment of Neglect dyslexia SANTA LUCIA RF‐2011‐ 02352445 Biomarkers of effect as novel tools for the identification of PCB contamination in mussels and their impact on human health. IZS Umbria e delle Marche RF‐2011‐ 02351012 In vivo safety and tolerability of sorghum based gluten free products in coeliac patients Campania RF‐2011‐ 02349298 Early genomic and cellular markers in sporadic colorectal cancer: an integrative methodological approach combining the response of biomarkers in organ biopsies and in a healthy cell system like peripheral mononuclear cells. Toscana RF‐2011‐ 02352643 NEOADJUVANT CHEMOTHERAPY AND RADICAL SURGERY IN TREATMENT OF LOCALLY ADVANCED CERVICAL CARCINOMA: 18F‐FDG‐PET/CT AND MOLECULAR BIOLOGY PREDICTIVE VALUE IN EARLY AND LATE ASSESSMENT OF RADICAL SURGERY FEASIBILITY AND ITS SURVIVAL IMPACT Sicilia RF‐2011‐ 02352315 A Randomized Clinical Double Blind Placebo Controlled Study of Human Fecal Microbioma in Irritable Bowel Syndrome Treated with Probiotic and a Boswellia Serrata Gum Extract Tritated in Boswellic Acids Toscana Tipologia Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Brain Disorders and Clinical Neuroscience Neurological diseases Veterinary Food safety and animal welfare 24,5 Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Food safety and animal welfare 24,5 Biomedical Genes, Genomes and Genetics Oncology 24,5 Clinical Oncology 2 ‐ Translational Clinical Oncology 24,5 Clinical Digestive, Kidney and Urological Systems Infection and immunity 24,5 Biomedical 24,25 Pagina 208 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351675 Rational and innovative design of immunogens based on HIV‐1 clade C Env proteins specifically mutated in glycan moieties for broadly effective vaccine purpose ISS RF‐2011‐ 02348398 Observational population‐based study on ovarian cancer management within the Piedmont Region Cancer Network Piemonte RF‐2011‐ 02349233 Directing the axonal outgrowth via magnetic nanoparticles and magnetic fields for nerve regeneration: a pre‐clinical study Toscana RF‐2011‐ 02348441 Lung water assessment by quantitative chest ultrasonography in cardiac surgery patients Emilia‐Romagna RF‐2011‐ 02349862 Role of miR‐494 and other microRNAs in Src kinase inhibition of colorectal cancer stem cells RF‐2011‐ 02347437 RF‐2011‐ 02350315 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. AIDS and Related Research Infection and immunity 24,5 Healthcare Delivery and Methodologies Oncology 24,75 Molecular, Cellular, and Developmental Neuroscience Neurological diseases 25 Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 25 Umbria Biomedical Oncology 1 ‐ Basic Translational Oncology 25 Role of HDL and endothelial dysfunctions in modulating the impact of risk factors on sub clinical atherosclerosis in diabetes Toscana Clinical Vascular and Hematology Metabolism disorders and cardiovascular disease 25 Early detection of chronic obstructive pulmonary disease induced by industrial pollutants by analysis of volatile organic compounds from exhaled breath. Puglia Clinical Cardiovascular and Respiratory Sciences Diseases of environmental origin, with reference also to the workplace 25 Clinical Biomedical Pagina 209 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02352531 New ultrasonic methods for OSTEOporosis diagnosis at the proximal FEMur (OSTEOFEM) Puglia Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 25 RF‐2011‐ 02348360 Identification of host prion proteins resistant to template‐conversion into PrPSc IZS Umbria e delle Marche Biomedical Veterinary Food safety and animal welfare 25 RF‐2011‐ 02350825 Immunological and virological monitoring of opportunistic virus infections in systemic lupus erythematosus patients SAN MATTEO Biomedical Immunology Infection and immunity 25 RF‐2011‐ 02350711 Attenuation of the Hippo pathway by praja2 reduce glioblastoma growth NEUROMED Biomedical Oncology 1 ‐ Basic Translational Oncology 25 RF‐2011‐ 02352584 Klebsiella Pneumoniae carbapenemases (KPCs) positive strains in hospitalized decompensated cirrhotic patients: a nationwide epidemiologic survey and the evaluation of a new eradication treatment based on faecal‐microbiota transplantation Emilia‐Romagna Clinical Infectious Diseases and Microbiology Infection and immunity 25 RF‐2011‐ 02348365 Genetic and functional analysis for I.E.O. identification of driver pathways of resistance in breast cancer metastases and xenograft obtained from patients with triple negative, HER2 positive and Luminal B subtypes Clinical Oncology 2 ‐ Translational Clinical Oncology 25 RF‐2011‐ 02351730 Efficacy of Etanercept vs Adalimumab in retreating psoriatic patients who previously failed treatment with the same molecule Clinical Musculoskeletal, Oral and Skin Sciences Infection and immunity 25 SAN GALLICANO Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 210 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347987 Oxidative stress and microRNA‐125b: from molecular mechanisms to therapeutic implications in Hailey‐Haileydisease ISS RF‐2011‐ 02352341 ECG IN UN CLIK RF‐2011‐ 02350351 Exploitation of genetically engineered oral carcinoma relapse models for development and pre‐clinical assessment of targeted combinatorial therapeutic strategies RF‐2011‐ 02348239 A novel anti‐CXCR4 drug RFF‐1: a Phase I/II PASCALE Clinical Trial RF‐2011‐ 02348558 Combined intravenous and intra‐arterial thrombolysis for ischemic stroke due to large vessel occlusion: feasibility, safety and effectiveness. AOU San Martino‐IST ‐ Genova RF‐2011‐ 02352027 Protein‐based carriers for targeted photodynamic therapy Emilia‐Romagna RF‐2011‐ 02351398 Identification of mycobacterial cell surface molecules as molecular markers of disease Campania RF‐2011‐ 02347096 Prostate cancer: a study on the mechanisms AOU San Martino‐IST ‐ underlying the development of androgen‐ Genova independence to identify early biomarkers and new therapeutic targets Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Musculoskeletal, Oral and Skin Sciences Metabolism disorders and cardiovascular disease 25 Lazio Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 25 Emilia‐Romagna Clinical Oncology 2 ‐ Translational Clinical Oncology 25 Biomedical Oncology 2 ‐ Translational Clinical Oncology 25 Brain Disorders and Clinical Neuroscience Neurological diseases 25 Biomedical Oncology 1 ‐ Basic Translational Oncology 25 Biomedical Infectious Diseases and Microbiology Infection and immunity 25 Biomedical Oncology 1 ‐ Basic Translational Oncology 25 Clinical Pagina 211 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02352371 Cardiovascular disease in intrauterine growth restriction (IUGR). A clinical and proteo‐metabolomic investigation. Veneto Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences The new biotechnologies 25 RF‐2011‐ 02348938 Sustainable innovation of husbandry practices to improve animal health and welfare and to reduce the use of antimicrobials in broiler chickens IZS Venezie Biomedical Veterinary Food safety and animal welfare 25 RF‐2011‐ 02349194 THERAPEUTIC DEVICE OF AREA FOR ADOLESCENTS WITH SEVERE PSYCHIATRIC DISORDERS. INTENSIVE SPECIFIC OUT‐PATIENT SERVICE Lombardia Clinical Risk, Prevention and Health Behavior Neurological diseases 25,5 RF‐2011‐ 02350541 Inflammatory links between obesity, ISS asthma and adaptive immunity in childhood Immunology Infection and immunity 25,5 RF‐2011‐ 02352703 Contribution of the different risk factors to the prevalence of gestational diabetes mellitus. A cohort study. Emilia‐Romagna Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 25,5 RF‐2011‐ 02351519 Toxic and infective agents as potential cause of congenital malformations of domestic ruminant calves in southern Italy. IZS Mezzogiorno Biomedical Veterinary Diseases of environmental origin, with reference also to the workplace 25,5 RF‐2011‐ 02351639 Effectiveness of oncology drugs of AIFA Oncology Register AOU San Martino‐IST ‐ Genova Oncology 2 ‐ Translational Clinical Oncology 25,5 Biomedical Clinical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 212 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351772 An economic, randomized, prospective phase III trial comparing the combination of anthracycline‐taxane vs bevacizumab‐ paclitaxel as first‐line treatment in women with HER‐2 negative metastatic breast cancer RF‐2011‐ 02352481 Study of the selectivity of botulinum toxins Toscana (BoNT‐A and BoNT‐C) for muscle fiber type units and their kinetics diffusion by exo‐ endocytosis: electro and impedence myography evaluation, biochemical pathway analysis and possible clinical implication in Sp RF‐2011‐ 02352676 Tipologia AREA STRATEGICA SCORE. Oncology 2 ‐ Translational Clinical Oncology 25,5 Biomedical Molecular, Cellular, and Developmental Neuroscience Neurological diseases 25,5 Genetic Polymorphisms and pain sensitivity Sicilia in a Sicilian population of oncological patients Biomedical Oncology 2 ‐ Translational Clinical Oncology 25,5 RF‐2011‐ 02351862 Ecological and biomolecular studies on Culicoides for an innovative approach to the control of Culicoides transmitted diseases IZS Sicilia Biomedical Infectious Diseases and Microbiology Diseases of environmental origin, with reference also to the workplace 25,75 RF‐2011‐ 02349501 FISH FARMING AND WELFARE: ASSESSMENT OF ACOUSTIC, THERMAL AND CHEMICAL STRESS FOR A MORE AQUACULTURE SUSTAINABLE IZS Piemonte, Liguria e Valle d'Aosta Biomedical Veterinary Food safety and animal welfare 25,75 RF‐2011‐ 02347868 Novel clinical applications of autologous adipose‐derived stem cells. Emilia‐Romagna Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 26 REGINA ELENA Clinical Classificazione 1 Liv. Clinical Pagina 213 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351472 Influence of cell‐cell adhesion molecules expression on the metastatic growth of colon cancer stem cells in liver. ONCOLOGICO DI BARI RF‐2011‐ 02349688 ASSISTENTIAL AFTERMATH OF DISTRESS IN MATERNIY WARD PROFESSIONALS FACING MISCARRIAGE, STILLBIRTH AND PERINATAL GRIEF Piemonte RF‐2011‐ 02350933 ANALYSIS OF ADIPONECTIN SYSTEM AS NEW TARGET FOR DIAGNOSIS AND THERAPY OF CHRONIC OBSTRUCTIVE PULMONARY PATIENTS WITH COEXISTENT CARDIOVASCULAR DISEASE SDN RF‐2011‐ 02350396 Nanoparticles as drug delivery system for the therapy of Mesothelioma and Pancreatic Cancer. PASCALE RF‐2011‐ 02347343 COCAINE AND CHEST PAIN Emilia‐Romagna RF‐2011‐ 02347163 The anatomical substrate of unilateral neglect subtypes: behavioral and neuroimaging investigation RF‐2011‐ 02352675 SURVEILLANCE OF THE PREVALENCE OF PERIODONTITIS AND CHARACTERIZATION OF MICROBIOLOGICAL PROFILE IN A REPRESENTATIVE ADULT ITALIAN POPULATION. Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Oncology 1 ‐ Basic Translational Oncology 26 Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 26 Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 26 Biomedical Oncology 2 ‐ Translational Clinical Oncology 26 Clinical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease 26 S.CAMILLO Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 26 SPALLANZANI Biomedical Infectious Diseases and Microbiology Infection and immunity 26 Clinical Pagina 214 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02348102 BLeeding Events and Maintenance DoSe of PraSugrel. Toscana RF‐2011‐ 02348298 Functional Imaging and Transcriptomics for Prediction of Ovarian cancer response to Trabectedin ISS RF‐2011‐ 02350324 A GENETIC, CLINICAL AND SOCIAL INVESTIGATION OF DEMENTIA IN NORTH‐EASTERN ITALY RF‐2011‐ 02352110 Innovative biomarkers for oxidative stress in diabetic retinopathy: evaluation of curcumin inhibition. RF‐2011‐ 02348357 Natural history of circulating Endothelial Toscana Progenitor Cells in aging of healthy subjects and during vascular injury progression in patients with type 1 diabetes. Validation of the role of circulating Endothelial Progenitor Cells as a novel paradigm of Ca Clinical RF‐2011‐ 02352575 Omics study of competitive action of starter Abruzzo add on fresh meat production (italian salami) to improve safety Biomedical RF‐2011‐ 02351967 Impact of Atorvastatin Use on Death or clinical Events Occurrence among HIV‐1 infected patients without hyperlipidemia. AUDEO Study AREA STRATEGICA SCORE. Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 26 Biomedical Oncology 2 ‐ Translational Clinical Oncology 26 Veneto Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 26 BIETTI Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 26 Vascular and Hematology Metabolism disorders and cardiovascular disease 26 Infectious Diseases and Microbiology Food safety and animal welfare 26 AIDS and Related Research Infection and immunity 26 SAN RAFFAELE Milano Clinical Classificazione 1 Liv. Clinical Pagina 215 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02348367 IDENTIFICATION AND ANALYSIS OF MOLECULAR ALTERATIONS IN ENDOTHELIAL CELLS DERIVED FROM CEREBRAL CAVERNOUS MALFORMATIONS NEUROLESI RF‐2011‐ 02350900 Chest pain in the Emergency Department : the role of diabetes, dyslipidemia and obesity in the incidence of ACS in population with/without a history of CAD. Mortality, reinfarction and survival related factors AOU San Martino‐IST ‐ Genova RF‐2011‐ 02350590 Infective exacerbations of COPD, comorbidity and gender differences Puglia RF‐2011‐ 02351973 Burden of disease of work related asthma Toscana RF‐2011‐ 02348491 Effects of peripheral sensory pressure stimulation on the cardiovascular autonomic profile, inflammatory state and movement disorders in patients with Parkinson's disease: evaluation of the time course and underlying neurophysiological mechanisms. A new c HUMANITAS RF‐2011‐ 02351114 Role of autophagy and cell oxidation in Hungtinton Disease (HD) RF‐2011‐ 02352033 Developing a Nutritional genomics approach for the prevention of Colon cancer Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Brain Disorders and Clinical Neuroscience Neurological diseases 26 Clinical Population Sciences and Epidemiology Metabolism disorders and cardiovascular disease 26 Clinical Cardiovascular and Respiratory Sciences Infection and immunity 26 Population Sciences and Epidemiology Diseases of environmental origin, with reference also to the workplace 26 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 26,25 Piemonte Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 26,5 Sicilia Biomedical Oncology 2 ‐ Translational Clinical Oncology 26,5 Biomedical Pagina 216 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02350612 DEACETILASE INHIBITORS AS NEW TOOLS TO CONTROL LOCAL INVASION AND METASTASIS OF ENDOCRINE‐ RELATED TUMORS Piemonte Biomedical Oncology 1 ‐ Basic Translational Oncology 26,5 RF‐2011‐ 02350897 Primary cancer cells as models to test new drugs and to personalize the therapy Campania Biomedical Oncology 2 ‐ Translational Clinical Oncology 26,5 RF‐2011‐ 02352409 Analysis of myocardial function after aortic valve replacement with a novel sutureless valve: coupling mathematical modelsto clinical research. Sicilia Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering Metabolism disorders and cardiovascular disease 26,5 RF‐2011‐ 02349742 DEVELOPMENT OF LABORATORY PROCEDURES TO ASSESS BIOFILM PRODUCTION AND DRUG RESISTANCE OF BIOFILM‐FORMING BACTERIA FOR NOSOCOMIAL SURVEILLANCE AND THERAPEUTIC MANAGEMENT SAN GALLICANO Clinical Infectious Diseases and Microbiology Infection and immunity 26,5 RF‐2011‐ 02350096 Prevention of nosocomial Legionnaires' disease: use of spoligotyping in evaluating L. pneumophila susceptibility to chlorine and monochloramine. Sicilia Biomedical Infectious Diseases and Microbiology Infection and immunity 26,5 RF‐2011‐ 02351388 Prevention of restenosis after percutaneous transluminal angioplasty (PTA) MULTIMEDICA Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering Metabolism disorders and cardiovascular disease 26,5 RF‐2011‐ 02349028 Intensive vs non‐intensive rehabilitation SANTA LUCIA program in Parkinson's disease (PD) patients. Study for evaluating a non invasive approch to increase neurotrophic factors in the brain of PD patients. Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 26,5 AREA STRATEGICA SCORE. Pagina 217 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02349070 Mens sana in corpore sano? The impact of multi‐year exercise on physical and mental health at different ages. Toscana Biomedical RF‐2011‐ 02351963 The oral modifications in very early and established Systemic Sclerosis Toscana RF‐2011‐ 02351137 Pathophysiology of central fatigue in patients with multiple sclerosis: an integrated neurophysiologic and neuroimaging approach. NEUROLESI RF‐2011‐ 02350962 Efficacy of Magnetic Fields stimulation for the treatment of human gastric cancer associated, or not, to pathogen Helicobacter pylori infection. Piemonte RF‐2011‐ 02347336 Multi‐disciplinary approach to predict adverse ventricular remodeling in post‐MI patients: combined evaluation of cardiac dysfunction and immune‐related biomarkers after revascularization procedure RF‐2011‐ 02348957 RF‐2011‐ 02352658 Classificazione 1 Liv. AREA STRATEGICA SCORE. Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease 26,5 Clinical Musculoskeletal, Oral and Skin Sciences Infection and immunity 26,5 Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 26,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 26,5 Lombardia Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 26,75 Application of optical nanoplasmonic biosensors as a complementary tool for the early detection of Legionella spp in water systems. (NANOBIOLEG) Puglia Biomedical Bioengineering Sciences and Technologies Diseases of environmental origin, with reference also to the workplace 27 Hospital Procedures for acute heart failure and integrated country/hospital healthcare Sicilia Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 27 Pagina 218 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02348613 MELATONIN LOADED NANOPARTICLES FOR POSTNATAL TREATMENT OF CEREBRAL PALSY IN A RAT MODEL Toscana Biomedical Brain Disorders and Clinical Neuroscience The new biotechnologies 27 RF‐2011‐ 02351482 Randomised Controlled Trial on lifestyle impact on health outcomes in the general population invited to mammography and colorectal cancer screening programmes. Piemonte Biomedical Risk, Prevention and Health Behavior Oncology 27 RF‐2011‐ 02351751 Incidence and outcome of ocular infections Sicilia caused by multi drug‐resistant microorganisms in intensive care unit patients: clinical, epidemiological and therapeutic management. Infectious Diseases and Microbiology Infection and immunity 27 RF‐2011‐ 02352213 Human defensins: a new weapon or an old enemy? Campania Immunology Infection and immunity 27 RF‐2011‐ 02348453 Primary Central Nervous System Vasculitis in the Young. A diagnostic and follow‐up study using 7‐Tesla MRA. Toscana Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 27 RF‐2011‐ 02348524 Effect of stress ( and psychological factors) on immune and endocrine systems in patients affected by breast carcinoma and hormone‐correlated tumours. I.N.R.C.A. Clinical Biobehavioral and Behavioral Processes Oncology 27 RF‐2011‐ 02347802 Genetic characterization of Non‐Small‐Cell Lung Cancer (NSCLC) to evaluate intratumor heterogeneity and modification after Tyrosine Kinase Inhibitors' (TKI) failure C.R.O. AVIANO Clinical Oncology 1 ‐ Basic Translational Oncology 27 Clinical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 219 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02347109 Role of growth hormone‐releasing hormone Piemonte (GHRH) in cardiac hypertrophy Biomedical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 27 RF‐2011‐ 02350540 Palitoxins: toxicity studies and development IZS Piemonte, Liguria e of new rapid methods of detection Valle d'Aosta Biomedical Veterinary Food safety and animal welfare 27 RF‐2011‐ 02350552 Eating disorders and risk factors for metabolic and cardiovascular diseases. A follow‐up study after ten years from the initial diagnosis Emilia‐Romagna Clinical Biobehavioral and Behavioral Processes Metabolism disorders and cardiovascular disease 27 RF‐2011‐ 02352574 Lab‐on‐chip technology and new clinical application Lazio Biomedical Bioengineering Sciences and Technologies The new biotechnologies 27 RF‐2011‐ 02352150 Molecular pathogenetic mechanisms and prognosis of sinonasal adenocarcinomas in relation to occupational exposure Piemonte Oncology 2 ‐ Translational Clinical Oncology 27 RF‐2011‐ 02352159 Chemical, biological, and clinical characterization of silver delivery systems for burns treatment Veneto Bioengineering Sciences and Technologies The new biotechnologies 27,5 RF‐2011‐ 02351769 Randomized Controlled Trial on the ARCISPEDALE‐Reggio efficacy of LLLT (Low Level Laser Therapy) Emilia in combination with standard treatment, in preventing and treating chemo/radiotherapy‐induced oral mucositis in head and neck cancer patients and in hematologic neoplasms patien Healthcare Delivery and Methodologies Oncology 27,5 RF‐2011‐ 02349644 Molecular and cellular correlates of vitamin D‐ dependent antimicrobial activity in an ovine model of local immunefunctions Veterinary Infection and immunity 27,5 IZS Sardegna Tipologia Clinical Biomedical Clinical Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 220 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02350322 Titanium‐based third generation biomimetic scaffolds for bone tissue regeneration SAN MATTEO RF‐2011‐ 02349254 Copayment and compliance to the diagnostic therapeutic pathways AGENAS Clinical RF‐2011‐ 02350354 Endothelial progenitor cells, cardiovascular health and longevity.A prospective study in centenarians and their offspring from Marche. I.N.R.C.A. RF‐2011‐ 02350822 Gold compounds, potential anticancer agents with an innovative mode of action: mechanistic studies and in vivo evaluation Toscana RF‐2011‐ 02349709 Pulmonary Embolism: diagnosis, treatment, Lombardia management and outcomes in a general hospital with a fully computerized information system. RF‐2011‐ 02350982 Incidence, persistence and clearance of anal SAN GALLICANO Human Papillomavirus infection in a cohort of immunocompetent and immunocompromised males: a longitudinal study. RF‐2011‐ 02352696 Endocannabinoid system and Human Ovarian Tumors Campania Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Bioengineering Sciences and Technologies The new biotechnologies 27,5 Healthcare Delivery and Methodologies Metabolism disorders and cardiovascular disease 27,5 Biomedical Biology of Development and Aging Metabolism disorders and cardiovascular disease 27,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology 27,5 Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 27,5 Biomedical Infectious Diseases and Microbiology Infection and immunity 27,5 Biomedical Oncology 2 ‐ Translational Clinical Oncology Clinical 28 Pagina 221 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351992 Early detection of the onset of potential risk IZS Lazio e della Toscana in order to counteract and to prevent their spread. An introduction of an advanced computer system that, with a right level of automation, collect information available on the internet to monitor their conten RF‐2011‐ 02348737 Comparative Effectiveness of dual antiplatelet therapy after acute coronary syndromes Emilia‐Romagna RF‐2011‐ 02350619 Myocardial Infarction in Low Risk Patients: Integrating Risk Assessment with Tissue Biomarkers and Metabolomics RF‐2011‐ 02349566 Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Veterinary Food safety and animal welfare 28 Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 28 Toscana Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease 28 Randomized controlled study for the implementation of a new interprofessional model for the management of palliative care in oncological patients Toscana Clinical Healthcare Delivery and Methodologies Oncology 28 RF‐2011‐ 02348650 Genetic response of colorectal carcinoma to chemotherapy to predict tumor response and circumvent chemoresitance Veneto Biomedical Oncology 2 ‐ Translational Clinical Oncology 28 RF‐2011‐ 02349043 IMPROVING THERAPEUTIC RESPONSES IN MELANOMA THROUGH THE COMBINATION OF TARGET AND IMMUNOLOGIC THERAPIES: AN IN VITRO AND IN VIVO STUDY Lombardia Biomedical Oncology 2 ‐ Translational Clinical Oncology 28 RF‐2011‐ 02351995 Facing dourine challenge: improvement of diagnostic tools and investigation of pathogenic mechanisms IZS Abruzzo e del Molise Biomedical Veterinary Food safety and animal welfare 28,25 Pagina 222 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02349431 Hemoglobin A1c (HbA1c) levels and early markers of cardiovascular disease: DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Sicilia Clinical Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Lazio Clinical Oncology 2 ‐ Translational Clinical Oncology 28,5 28,25 identification of cardiometabolic risk in pre‐ diabetic subjects. RF‐2011‐ 02349667 IMPLEMENTATION AND ASSESMENTOF AN ORGANIZATIONAL SIMULTANEOUS CARE MODEL RF‐2011‐ 02348745 Implementation of reading/writing learning Puglia method called "Globalismo Affettivo" in children with Neuropsychiatric Disorders Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 28,5 RF‐2011‐ 02351877 Effects of Mirror Visual Feedback Therapy (MVFT) in neuropathic pain syndromes. Possible role played by sensory‐motor cortical reorganization evaluated by 3T‐ fMRI. MAUGERI Clinical Integrative, Functional, and Cognitive Neuroscience Neurological diseases 28,5 RF‐2011‐ 02349135 A new kinkless polyurethane‐silicone vascular graft implanted as femoropopliteal bypass for ischemic limb salvage: a pilot clinical study. Emilia‐Romagna Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering Metabolism disorders and cardiovascular disease 28,5 RF‐2011‐ 02349540 Design and implementation of a national network for remote identification of parasite arthropodes. IZS Abruzzo e del Molise Biomedical Veterinary Food safety and animal welfare 28,5 RF‐2011‐ 02352016 Healthcare Associated Infections and Sicilia Automated Area Decontamination: a challenge for the intended application, the evidence base for effectiveness, affordability of implementation and cost constraints Infectious Diseases and Microbiology Infection and immunity 28,5 Clinical Pagina 223 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02352755 Detection and molecular characterization of Cryptosporidium, Giardia and Toxoplasma oocysts/cysts in bivalve mollusks destined for human consumption. RF‐2011‐ 02351516 DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Veterinary Food safety and animal welfare 29 REGINA ELENA Improving therapeutical potential of histone deacetylases inhibitors in non‐small cell lung cancer Biomedical Oncology 2 ‐ Translational Clinical Oncology 29 RF‐2011‐ 02349424 Transcranial Magnetic Stimulation in alcohol dependence Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 29 RF‐2011‐ 02350797 Building of MM associated vascular niche to SAN RAFFAELE Milano dissect MM‐endothelial cells dialogue Biomedical Oncology 1 ‐ Basic Translational Oncology 29 RF‐2011‐ 02352326 Complementary and Alternative Medicine for the treatment of chronic pain: a pilot study NEUROLESI Biobehavioral and Behavioral Processes Neurological diseases 29 RF‐2011‐ 02352441 CHLORPYRIFOS, DELTAMETRIN AND DIAZINON, A REAL RISK FOR ANIMAL AND HUMAN HEALTH. EVALUATION OF GENOTOXICITY, OXIDATIVE STRESS, HORMONAL AND TISSUTAL RESPONSES IN FISH EXPERIMENTALLY EXPOSED TO PESTICIDES IZS Piemonte, Liguria e Valle d'Aosta Veterinary Food safety and animal welfare 29 RF‐2011‐ 02352208 Enhancing and monitoring indoor and outdoor physical activity and its intracellular and quality of life effects in type 2 diabetic patients Lombardia Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease 29 IZS Sardegna Lazio Clinical Biomedical Clinical Pagina 224 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351721 Interactions between Circulating Tumor DE BELLIS Cells (CTCs) and the hepatic microenvironment in human metastatic colorectal cancer: The ADAM‐9 protein as a target for tumor/stromal therapy. RF‐2011‐ 02352240 Melanoma and non‐melanoma skin cancer: anatomic site, sun exposure, predictive and prognostic biomarkers RF‐2011‐ 02348303 Tipologia Classificazione 1 Liv. AREA STRATEGICA SCORE. Biomedical Oncology 1 ‐ Basic Translational Oncology 29,5 SAN GALLICANO Clinical Oncology 1 ‐ Basic Translational Diseases of environmental origin, with reference also to the workplace 29,5 Hypermethylation and downregulation of IRX1 gene induced by Helicobacter pylori infection: etiopathogenetic role in gastric cancer development, prognostic impact after surgical resection and diagnostic employment as screening test SAN RAFFAELE Milano Clinical Oncology 2 ‐ Translational Clinical Oncology 29,5 RF‐2011‐ 02352557 Proteomic profiling of hematological malignancies by Reverse Phase Protein Array: an innovative traslational approach to identify biomarkers for prognosis and molecular therapy. Lazio Biomedical Oncology 2 ‐ Translational Clinical Oncology 29,5 RF‐2011‐ 02349136 FROM REMOTE MONITORING TO REMOTE CARE: IMPACT ON CLINICAL AND MANAGEMENT ISSUES OF AN INTEGRATED APPROACH TO FOLLOW HEART FAILURE PATIENTS WITH IMPLANTABLE CARDIAC DEVICES. Emilia‐Romagna Cardiovascular and Respiratory Sciences Metabolism disorders and cardiovascular disease Clinical 29,75 Pagina 225 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02351764 Zoonotic risks assessment of the handling and consumption of meat from main wild ungulates (wild boar/Sus scrofa, roe deer/Capreolus capreolus) hunted in Nord Italy (Aosta Valley Region) and South Italy (Calabria Region) IZS Piemonte, Liguria e Valle d'Aosta Biomedical Veterinary Food safety and animal welfare 30 RF‐2011‐ 02348870 From psycho‐social stress to immuno‐ mediated dermatoses (vitiligo and psoriasis): a molecular approach. Toscana Biomedical Immunology Infection and immunity 30 RF‐2011‐ 02352200 Definition of an Integrated Risk Assessment Sicilia of Health Care Worker Biomechanical Musculoskeletal Overload Clinical Healthcare Delivery and Methodologies Diseases of environmental origin, with reference also to the workplace 30 RF‐2011‐ 02347189 BEVO SIRCOPANOS (endocrine Benefits from Sicilian Extra Virgin Olive Oil, Sicilian Red wine and Consumption of Pesce Azzurro but No Smoking): a project by the Program of Molecular & Clincical Endocrinology and Women's Endocrine Health. Sicilia Clinical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Diseases of environmental origin, with reference also to the workplace 30 RF‐2011‐ 02350672 Clinical implications of gene polymorphism (TAAA)n of sex hormone‐binding globulin in breast cancer patients with or without hormone‐therapy. ONCOLOGICO DI BARI Biomedical Genes, Genomes and Genetics Oncology 30 RF‐2011‐ 02348251 MICROENVIRONMENT INFLUENCE ON CANCER STEM CELL DEVELOPMENT Veneto Biomedical Oncology 1 ‐ Basic Translational Oncology 30 AREA STRATEGICA SCORE. Pagina 226 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02351819 Role of LXR alpha and related target genes in the pathogenesis of atherosclerosis. Evaluations in patients with different stages of atherosclerotic disease. Lombardia Biomedical Cardiovascular and Respiratory Sciences Infection and immunity 30 RF‐2011‐ 02352656 MECHANOTRANSDUCTION FOR THE TREATMENT OF OSTEOPOROSIS: MECHANISM OF ACTION, PRECLINICAL AND CLINICAL EFFICACY OF EXTRACORPOREAL SHOCK WAVES (ESW) FOR THE PREVENTION OF PATHOLOGICAL FEMORAL NECK FRACTURES RIZZOLI Biomedical Musculoskeletal, Oral and Skin Sciences The new biotechnologies 30 RF‐2011‐ 02348580 A translational medicine research collaboration to fight preeclampsia: from molecular pathogenesis to biomarkers of the disease and novel treatments Veneto Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Sciences Metabolism disorders and cardiovascular disease RF‐2011‐ 02347348 Validation of Augmented Reality Navigation for HIFU Treatments Toscana Clinical Surgical Sciences, Biomedical Imaging, and Bioengineering Oncology 31 RF‐2011‐ 02352659 Production of honey‐based materials from Italian honey and their application in medicine and surgery Piemonte Biomedical Surgical Sciences, Biomedical Imaging, and Bioengineering The new biotechnologies 31 RF‐2011‐ 02350800 Short term cultures of surgical tissue slices to evaluate the sensitivity of breast cancer subtypes to the anti‐tumor effects of all‐ trans retinoic acid and derived retinoids: identification of the cellular and molecular determinants ARCISPEDALE‐Reggio Emilia Biomedical Oncology 2 ‐ Translational Clinical Oncology 31 AREA STRATEGICA SCORE. 30,5 Pagina 227 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE RF‐2011‐ 02351015 Realization of a protocol for the rapid identification of etiological agent/s responsible for sepsis directly from peripheral blood of septic subjects, by integration of molecular biology, mass‐ spectrometry and classical methods. Toscana RF‐2011‐ 02348864 Outcome of Rehabilitation in an experimental Hospital garden: a prospective, quasi‐experimental study on a sample of subacute stroke patients. Emilia‐Romagna RF‐2011‐ 02352268 Study of bio‐molecular and immunological ONCOLOGICO DI BARI mechanisms of response and resistance to targeted therapy (antiBRAF, antiMEK, or both) in patients with metastatic melanoma RF‐2011‐ 02352651 SOW Project: safety on work. An intervention to increase attention of workers, making them aware of risky behavior in psychoactive substances consumption. Campania RF‐2011‐ 02352083 Colorectal cancer stem cells, microenvironment and improved diagnosis for potential therapy Toscana RF‐2011‐ 02347172 Risk maps of MAP (Mycobacterium avium subsp. paratuberculosis) using advances technologies IZS Lazio e della Toscana Tipologia Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Infectious Diseases and Microbiology The new biotechnologies 31 Brain Disorders and Clinical Neuroscience Neurological diseases 31 Oncology 2 ‐ Translational Clinical Oncology 31 Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace Biomedical Oncology 1 ‐ Basic Translational Oncology 31,5 Biomedical Veterinary Infection and immunity 31,5 Clinical Biomedical Clinical 31,25 Pagina 228 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia RF‐2011‐ 02350865 Colorectal carcinogenesis: Study, in vivo and in vitro, of the molecular mechanisms of cell differentiation of the human colon cancer cells DE BELLIS Biomedical Oncology 1 ‐ Basic Translational Oncology 31,5 RF‐2011‐ 02352731 Aerobiological monitoring and allergy management in Abruzzo Abruzzo Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 31,5 RF‐2011‐ 02347025 Amniotic stem cells to improve congenital kidney damage: a fetal lamb model SAN MATTEO Biomedical Digestive, Kidney and Urological Systems The new biotechnologies 31,5 RF‐2011‐ 02352822 Development and performance evaluation of different assays for the study of the presence of viable Toxoplasma gondii in vegetable and meat IZS Piemonte, Liguria e Valle d'Aosta Biomedical Veterinary Food safety and animal welfare 32 RF‐2011‐ 02349284 Dissecting the role of chronic stress and its consequences on tumor growth and metastasis in animal models PASCALE Biomedical Oncology 1 ‐ Basic Translational Oncology 32 RF‐2011‐ 02346768 Population‐based active surveillance of acute HIV infection. SAN MATTEO Clinical AIDS and Related Research Infection and immunity 32,5 RF‐2011‐ 02352237 Link between clinical features of haematological patients, molecular and cytofluorimetric data: WT1 and relationship with other markers. Basilicata Clinical Oncology 2 ‐ Translational Clinical Oncology 32,5 RF‐2011‐ 02350876 Mechanisms and actions of Regorafenib (Stirvaga), a new hepatocarcinoma (HCC) therapy DE BELLIS Oncology 1 ‐ Basic Translational Oncology 32,5 Biomedical Classificazione 1 Liv. AREA STRATEGICA SCORE. Pagina 229 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO DESTINATARIO ISTITUZIONALE Tipologia Classificazione 1 Liv. RF‐2011‐ 02352618 Estimate of breast cancer risk in relation to mammographic density by using a software for automatic evaluation of the density. Toscana Biomedical Population Sciences and Epidemiology Oncology RF‐2011‐ 02350793 Evaluation of the immune response against Mycobacterium avium subsp. paratuberculosis in humans and animals IZS Umbria e delle Marche Biomedical Veterinary Infection and immunity 33,5 RF‐2011‐ 02350079 Asbestos dosage in biological tissues and fluids: standardization of sample preparation and analytical methods within National Health Service, Universities and Regional Environmental Protection Agencies laboratories. Toscana Biomedical Oncology 1 ‐ Basic Translational Oncology 33,5 RF‐2011‐ 02347545 Circulating microRNAs as novel biomarkers Toscana for Amyotrophic Lateral Sclerosis Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases 34 RF‐2011‐ 02352609 AN ITALIAN REGISTER OF NEONATAL EPILEPTIC ENCEPHALOPATHY Emilia‐Romagna Clinical Brain Disorders and Clinical Neuroscience Neurological diseases 34,5 RF‐2011‐ 02350437 Application of nanomechanical assays to detection of algal toxins IZS Lombardia e dell'Emilia Biomedical Veterinary Food safety and animal welfare 34,5 RF‐2011‐ 02347424 The integrated and multi‐disciplinary management of patients with peripheral arterial disease and lower limbs trophic lesions: improving adherence and quality of life Sicilia Clinical Risk, Prevention and Health Behavior Metabolism disorders and cardiovascular disease RF‐2011‐ 02352480 Sexual dysfunction after Traumatic Brain Injury and consequences on couple relationship: assessment and treatment. SANTA LUCIA Biomedical Brain Disorders and Clinical Neuroscience Neurological diseases AREA STRATEGICA SCORE. 33 35 35,5 Pagina 230 di 231 BANDO 2011‐2012 RICERCA FINALIZZATA ‐GRADUATORIA PROGETTI ORDINARI CODICE PROGETTO RF‐2011‐ 02351074 Direct management of litigation: a real chance to improve the Italian National Health System DESTINATARIO ISTITUZIONALE Toscana Tipologia Clinical Classificazione 1 Liv. Healthcare Delivery and Methodologies AREA STRATEGICA SCORE. Diseases of environmental origin, with reference also to the workplace 39 Pagina 231 di 231