MAY 2014
Curriculum Vitae – Hans Peter Frederik Koppeschaar
Hans P.F. Koppeschaar, MD, PhD, internist, endocrinologist, is a scientist at Emotional Brain and the
Alan Turing Institute Almere, Netherlands, where he conducts neurobiological research in the field of
Obesity and Sexual (dys)function.
Born in Indonesia of Dutch parents he received his medical training at the University of Amsterdam,
faculty of Medicine. He received his MD in 1974; Certificate Educational Commission for Foreign
Medical Graduates (ECFMG)(USA) 1977; Board certified in Internal Medicine 1979; PhD in Medicine
in 1983, University Utrecht, Netherlands.
He was appointed Consultant in Internal Medicine, Endocrinology and Metabolism in 1979, University
Medical Centre Utrecht; from 1985-1986 research fellow in Endocrinology with prof R.Hall and prof
M.Scanlon, Neuroendocrine Unit, University of Wales, College of Medicine, Cardiff, UK.
Until December 2009 he held the position of Consultant and Chief of the Department of Internal
Medicine , Division of Endocrinology and Diabetes, and associate Professor of Medicine and tutor
Endocrinology and Metabolism at the University Medical Centre Utrecht. Over the years he has
supervised the training of internal medicine residents and postdoctoral training in Endocrinology; also
12 graduate students have completed their thesis work under his supervision. Dr Koppeschaar has
been actively involved in research into many aspects of internal medicine, endocrinology and diabetes.
His research interests include the neuroendocrine regulation of pituitary and hypothalamic function;
the pathophysiology and treatment of pituitary and hypothamic disease; hormones and behaviour;
obesity and diabetes.
From 2001 on he is affiliated with Emotional Brain and the Alan Turing Institute, Almere, Netherlands,
as medical scientific advisor.
He is (co)author of well over 180 articles in peer-reviewed scientific journals and books, and has been
a lecturer for national and international symposia and conferences, and has made regularly scientific
presentations at meetings.
PERSONALIA
Last name
First name
Date of birth
Nationality
Centre address
Telephone
Fax
Email
BIG
PROFILE
1974
Koppeschaar
Hans
25 december 1943, Soerabaja, Indonesia
Dutch
Emotional Brain/Alan Turing Institute Almere
Louis Armstrongweg 78
1311 RL Almere, the Netherlands
+31 (0) 36-534 5985
+31 (0) 36-549 7186
h.koppeschaar@emotionalbrain.nl
69022186801
Medical School, University of Amsterdam, MD
Postgraduate training
1974 – 1979
1977
1979
1983
1985-1986
1991
Residency Internal Medicine
ECFMG Certificate (USA)
Board certified Internal Medicine
Doctor in Medicine, PhD thesis: Metabolic responses during modified fasting
and refeeding. The role of thyroid hormone and of catecholamines.
postdoctoral research fellow with prof R.Hall and prof M.Scanlon, Neuroendocrine
Unit, University of Wales, College of Medicine, Cardiff, UK
Registration as Internist-Endocrinologist
Curriculum Vitae – Hans Koppeschaar
1
MEMBERSHIP SCIENTIFIC Societies/ advisory and scientific boards
Present
Nederlandse Internisten Vereniging
Nederlandse Vereniging voor Endocrinologie
European Neuroendocrine Association
International Society of Psychoneuroendocrinology
Past
International Society for the study of the Aging Male
International Scientific Board K.I.M.S. (International database of adult GH deficient
patients
LRG ( Landelijke registratie groeihormoon volwassenen )
Dutch National Registry of Growth Hormone Treatment in Adults
Scientific Committee International Study on the longterm effects of
tetrahydrolipstatin in Obesity
Committee Gezondheidsraad inzake laag-energetische voeding
Committee Gezondheidsraad inzake adipositas
Advisory Board Over Gewicht van de Nederlandse Hartstichting
Deelwerkgemeenschap Regulatie van de hypofysefuncties van N.W.O.
Deelwerkgemeenschap Hormonen en voortplantingsfuncties van N.W.O.
Werkgroep Fertiliteitsprognose
Organizing Scientific Committee, European Congress on Obesity
Noordwijkerhout, Netherlands, 1992
Organizing Scientific Committee, Sixth International Workshop on Multiple
Endocrine Neoplasia, June 1997, Noordwijkerhout, Netherlands
Organizing Scientific Committee, International Symposium on New Developments
in treatment of type 2 Diabetes Mellitus and Obesity, December 2001
European Commission Committee, Reports on tasks for scientific cooperation.
Report of experts participating in Task 7.3 “Collection of data on products
intended for use in very-low-calorie-diets “ Dublin, Ireland, September 2002
Organizing Scientific Committee, International Symposium on Hormones and
Aging, Utrecht, Netherlands, April 2002
Organizing Scientific Committee, Symposium on “Hormonale uitval na
traumatisch hersenletsel : “ een onderschat probleem” Utrecht, Januari 2006
Board member for the Proceedings of the 39th International Symposium GH and
Growth Factors in Endocrinology and Metabolism, May 2007, Berlin, Germany.
Chairman Adult Clinical Session : Endocrine Incidentalomas; Horm Res, 68(suppl
5): 189-190, 2007
Curriculum Vitae – Hans Koppeschaar
2
Guest Editor Hormone Research From Developmental Endocrinology to Clinical
th
Research 38 International Symposium on Growth Hormone and Growth Factors
in Endocrinology and Metabolism Granada, Spain, April 7-8, 2006 ; Horm Res
67(suppl 1) 1-224 (2007)
AWARDS
1990
Stipendium voor sportgeneeskunde voor onderzoeksvoorstel: "De ontwikkeling
van geavanceerde testmethoden tot vaststelling van dreigende overtraining bij
topsporters/sters" (auteurs: drs. C. Vervoorn, dr. W. de Vries, dr. H.P.F.
Koppeschaar), 1990
1994
18 International Symposium on Growth Hormone and Growth Factors in
Endocrinology and Metabolism, Gothenburg, Sweden, October 1994. Price for
best clinical study: Adpose tissue, assessed by magnetic resonance imaging, in
Growth Hormone Deficient Adults: the effect of growth hormone replacement (
auteurs: Y.E.M. Snel, R.J.M. Brummer, M.E. Doerga, P.M.J. Zelissen, C.J.G.
Bakker, M.J. Hendriks, H.P.F. Koppeschaar)
2000
Glenn Foundation Endocrinology and Aging Award. 82th Annual Meeting
Endocrine Society, 2000, Toronto: GHRH- and GHRP-2 stimulated Growth
Hormone secretion in elderly men after reduction of free fatty acids by acipimox
(auteurs: P.S. van Dam, W.R. de Vries, H. Smid, M. Niesink, E. Bolscher, C.
Dieguez, F.F. Casanueva en H.P.F. Koppeschaar)
2002
34 International Symposium GH and Growth Factors in Endocrinology and
Metabolism, Budapest, Hungary, 2002. Price for best overall ( clinical and
preclinical ) study : Cognitive function,selective attention, event-related
potentials and 1H magnetic resonance spectroscopy in childhood-onset Growth
hormone deficiency (authors: P Sytze van Dam, M Lijffijt, A Wittenberg, W.R.de
Vries, M L Drent, J van der Grond, M N Verbaten, J L Kenemans, A Aleman, W
F de Haan, and H.P.F.Koppeschaar)
2011
93 rd Annual Meeting of the Endocrine Society, Boston,USA, June, 2011
Outstanding Abstract Award : Does Growth Hormone Replacement Therapy
reduce Mortality in Adults with Growth Hormone Deficiency?- Data from the
Dutch National Registry of Growth Hormone Treatment in Adults
(authors: Crista C van Bunderen, Caroline van Nieuwpoort, Lucia I Arwert,
Martijn W. Heymans, Anton A.M.Franken, Hans.P.F.Koppeschaar, Aart J.
van der Lely, Madeleine L. Drent)
th
th
Curriculum Vitae – Hans Koppeschaar
3
Reviewer
-
European Journal of Endocrinology
Obesity Research
Clinical Endocrinology
International Jounal of Obesity
Journal of Endocrinological Investigation
International Journal of Sports Medicine
Maturitas
Netherlands Journal of Medicine
Medical and Health Research NWO
Archives General Psychiatry
Diabetic Medicine, Journal of Diabetes UK
Hormone and Metabolic Research
Growth Hormone and IGF Research
Psychoneuroendocrinology
Hormone Research in Pediatrics
Nature Reviews Endocrinology
BMC Psychiatry
Curriculum Vitae – Hans Koppeschaar
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PUBLICATIONS
A.E. Meinders, H.P.F. Koppeschaar, V. Cejka, R. Michels, C. Oldenbroek
The influence of rehydration in uncontrolled insulin dependent diabetes mellitus
Neth J Med 1978; 21: 3-10.
A. Stofkoper, F. Schwarz, H.P.F. Koppeschaar, A.C. Klinkhamer, P. Wittebol
Percutane transhepatische portografie ter localisatie van een insulinoom
Ned Tijdschr Geneeskd 1982; 126: 1625-1629.
H.P.F. Koppeschaar, R.J.M. Croughs, J.H.H. Thijssen, F. Schwarz
Sodium valproate and heterogeneity of pituitary dependent Cushing's syndrome
The Lancet 1982; i: 1253.
H.P.F. Koppeschaar
Metabolic responses during modified fasting and refeeding: the role of thyroid hormone and of
catecholamines
Thesis, Utrecht, 1983.
H.P.F. Koppeschaar, A.E. Meinders, F. Schwarz
The effect of a low calorie diet alone and in combination with triiodothyronine therapy on weight loss
and hypophyseal thyroid function in obesity
Int J Obesity 1983; 7: 123-131.
H.P.F. Koppeschaar, A.E. Meinders, F. Schwarz
Metabolic responses in grossly obese subjects treated with a very low calorie diet with and without
triiodothyronine treatment
Int J Obesity 1983; 7: 133-141.
H.P.F. Koppeschaar, A.E. Meinders, F. Schwarz
The effect of modified fasting on blood pressure and sympathetic activity. A correlation.
Int J Obesity 1983; 7: 569-574.
F. Teding van Berkhout, R.J.M. Croughs, H.P.F.Koppeschaar, J.H.H. Thijssen, F.Schwarz,
C.Kooyman
Twee zusjes met het Syndroom van Cushing Ned Tijdschr Geneesk 1984; 128, 336-7
H.P.F. Koppeschaar, R.J.M. Croughs, J.H.H. Thijssen, F. Schwarz
Sodium valproate and cyproheptadine may independently induce a remission in the same patient with
Cushing's disease
Acta Endocrinol 1983; 104: 160-163.
H.P.F. Koppeschaar, R.J.M. Croughs, J.W. van 't Verlaat, M.J. Hendriks, C.J. Arts, J.H.H. Thijssen, F.
Schwarz
Successful treatment with sodium valproate of a patient with Cushing's disease and gross
enlargement of the pituitary
Acta Endocrinol 1984; 107: 471-475.
Curriculum Vitae – Hans Koppeschaar
5
H.P.F. Koppeschaar, A.E. Meinders, F. Schwarz
Metabolic responses during modified fasting and refeeding. The role of sympathetic nervous system
activity and thyroid hormones
Hum Nutr Clin Nutr 1985; 39: 17-28.
J.M. Arts, H.P.F. Koppeschaar, W. Veeman, J.H.H. Thijssen
A direct radioimmunoassay for the determination of adrenocorticotropic hormone (ACTH) and a clinical
evaluation
Ann Clin Biochem 1985; 22: 247-256.
M.J. Hendriks, J.W. van 't Verlaat, H.P.F. Koppeschaar, R.J.M. Croughs
Inferior petrosal sinus sampling in lateralization of ACTH-secreting pituitary microadenomas
N Engl J Med 1985; 312: 1457 (letter).
H.P.F. Koppeschaar, A.E. Meinders, F. Schwarz
Renal concentrating ability in Obesity. Effect of modified fasting, T3, sodium and carbohydrate
supplementation
Metabolism 1985; 34: 1066-1073.
H.P.F. Koppeschaar, A.E. Meinders
Gewichtsvermindering met behulp van caloriebeperking
Modern Medicine 1986; 1: 28-38.
P. Hill, J.H.H. Thijssen, F. de Waard, L. Garbackzewski, H.P.F. Koppeschaar
VIP and Prolactine release in response to meals
Scand J Gastroenterol 1986; 8: 958-961.
H.P.F. Koppeschaar, R.J.M. Croughs, J.H.H. Thijssen, F. Schwarz
Response to neurotransmitter modulating drugs in patients with Cushing's disease
Clin Endocrinol 1986; 25: 661-667.
H.J.H. Kreutzer, J.F.W. Tertoolen, J.H.H. Thijssen, P.J. der Kinderen and H.P.F. Koppeschaar
Analytical evaluation of four sensitive assays of Thyrotropin, including effects of variations in patient
sampling
Clin Chem 1986; 11: 2085-2092.
M.D. Page, H.P.F. Koppeschaar, C. Dieguez, J.T. Gibbs, R. Hall, J.R. Peters, M.F. Scanlon
Cholinergic muscarinic receptor blockade with pirenzepine abolishes slow wave sleep-related growth
hormone release in young patients with insulin-dependent diabetes mellitus
Clin Endocrinol 1987; 26: 355-359.
M.D. Page, H.P.F. Koppeschaar, C.A. Edwards, C. Dieguez, M.F. Scanlon
Additive effects of Growth Hormone Releasing Factor and Insulin Hypoglycemia on Growth Hormone
release in man Clin Endocrinol 1987; 26: 589-595.
F. Schwarz, H.P.F. Koppeschaar
Gebruik en misbruik van medicamenten bij de behandeling van Adipositas
IN: Voeding in de praktijk. Bohn, Scheltema en Holkema 1988; 111, D5: 1-6.
E.R. te Velde, J.W. van 't Verlaat, E. Scheenjes, H.P.F. Koppeschaar
Een man met azoospermie
Ned Tijdschr Geneeskd 1987; 131: 1640.
P. Hill, L. Garbackzewski, H.P.F. Koppeschaar, J.H.H. Thijssen, F. de Waard
Glucagon and insulin response to meals in lean and obese dutch women
Clin Chim Acta 1987; 65: 253-261.
Curriculum Vitae – Hans Koppeschaar
6
R.J.M. Croughs, H.P.F. Koppeschaar
Changing views on the pathogenesis of Cushing's disease in man
In: van Wimersma Greidanus Tj.B., ed.: Frontiers in hormone research, Karger, Basel, 1987; 17: 7885.
Hans F.A. Vasen, Arie C. Nieuwenhuijzen Kruseman, Hans Berkel, Erik K.M. Beukers, Constnat C.
Delprat, Rudi(L) G. Van Doorn, Rolf A. Geerdink, Harm R. Haak, Wil H.L. Hackeng, Hans P.F.
Koppeschaar, Erik P. Krenning, Steven W.J. Lamberts, Frits J. F. Lekkerkerker, Robert P.J. Michels,
Andre M.J. Moers, Gerlach F.F.M. Pieters, Wilmar M. Wiersinga, and Cees J.M Lips.
Multiple endocrine neoplasia syndrome type 2: The value of screening and central registration. A study
of 15 kindreds in The Netherlands.
Am J Med 1987; 83: 847-852.
C.J.M. van Binsbergen, J. Odink, H. van den Berg, H.J.T. Coelingh Bennink, H.P.F. Koppeschaar
Nutritional status in anorexia nervosa: clinical chemistry, vitamins, iron, and zinc
Eur J Clin Nutr 1988; 42: 929-937.
F.F. Casanueva, A.C. Charro, R. Valcavi, H.P.F. Koppeschaar, C. Dieguez
Neuroregulation of prolactin secretion in normal human subjects
In: Progress in Endocrinology, H. Imura, K. Shizume, S. Yoshida (Eds.) 1988: 1393-1399.
P. Hill, L. Garbaczewski, H.P.F. Koppeschaar, J.H.H. Thijssen, F. de Waard, E.L. Wynder
Peptide and steroid hormones in subjects at different risk for diet related diseases
Am J Clin Nutr 1988; 48: 782-786.
P. Hill, L. Garbaczewski, H.P.F. Koppeschaar, J.H.H. Thijssen, E.L. Wynder
Peptide Hormones, Digestion, and Menstrual Periodicity
In: The Menstrual Cycle and Its Disorders, Pirke/Wuttke/Schweiger (Eds), Springer-Verlag, BerlinHeidelberg 1989: 133-142.
T. Weits, E.J. van der Beek, M. Wedel, M.W.A. Hubben and H.P.F. Koppeschaar
Fat patterning during weight reduction: a multimode investigation
Neth J Med 1989; 4: 174-185.
H.W. van Hamersvelt, H.J.H. Kreutzer, J.F.W. Tertoolen, J.H.H. Thijssen and H.P.F. Koppeschaar
The immunofluorometric TSH assay as first line for suspected thyroid dysfunction
Neth J Med 1989; 4: 192-201.
T. Weits, H.P.F. Koppeschaar
Body Composition Measurements
Neth J Med 1989; 4: 204-218.
H.F.A. Vasen, C.B.H.W. Lamers, H. Haak, H.P.F. Koppeschaar, C.J.M. Lips
The Multiple Endocrine Neoplasia Syndrome I. The value of periodic examination. A study of 11
kindreds in the Netherlands
Arch Intern Med 1989; 149: 2717-2722.
R.J.M. Croughs, H.P.F. Koppeschaar, J.W. van 't Verlaat, A.M. McNicol
Bromocriptine-responsive Cushing's disease associated with anterior pituitary corticotroph hyperplasia
or normal pituitary gland
J Clin Endocr Metab 1989; 68: 495-499.
P. Hill, L. Garbaczewski, H.P.F. Koppeschaar, J.H.H. Thijssen
Leanness, peptide hormones and premenopausal breast cancer
Medical Hypothesis 1989; 28: 45-50.
P.M.J. Zelissen, R.J.M. Croughs, H.P.F. Koppeschaar, T.W.A. de Bruin, M.J. Hendriks, J.W. van 't
Verlaat
Primary hypothyroidism mimicking pituitary adenoma
Neth J Med 1989; 35: 95-99.
Curriculum Vitae – Hans Koppeschaar
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P.M.J. Zelissen, H.P.F. Koppeschaar
Polypeptide hormonen, honger en verzadiging.
Tijdschr Ned Ver Klin Chemie 1989; 14: 116-119.
Binsbergen C.J.M. van, H.J.T.Coelingh Bennink, A.A.Odink, A.A.Haspels, H.P.F. Koppeschaar
A comparative and longitudinal study on endocrine changes related to ovarian function in patients with
anorexia nervosa
J Clin Endocrinol Metab 1990; 71: 705-711.
Croughs R.J.M., A. Rijnberk, H.P.F. Koppeschaar
Heterogeneity in Cushing's disease
Neth J Med 1990; 36: 217-220.
M. Jadoul, H.P.F. Koppeschaar, M.A. Bax, W.P.Th. Mali, J.M. Wit, J. Huber et al,
Insulinomas in MEN-I patients: early detection and treatment of insulinomas in patients with the
multipele endocrine neoplasia syndrome type-I
Neth J Med 1990; 37: 95-102.
H. Seinen, H.P.F. Koppeschaar, C.J.M. Lips
Pseudo-hypoparathyreoidie; waar zit de kink in de kabel?
Ned Tijdschr Geneeskd 1990; 29: 1412-1418.
I.A. Huisveld, R. Leenen, K. v.d. Kooy, J.C. Seidell, P. Deurenberg, H.P.F. Koppeschaar,
W.L.Mosterd, B.N. Bouma
Body composition and weight reduction in relation to antigen and activity of Plasminogen Activator
Inhibitor (PAI-1) in overweight individuals
Fibrinolysis 1990; 2: 84-85.
Koppeschaar H.P.F., J.H.H.Thijssen
Laboratoriumonderzoek bij functieafwijkingen van de schildklier - Een handleiding voor
laboratoriumdiagnostiek in de eerste lijn
In: SAN Laboratoriumboek, J.P.Persijn, hoofdred. - Haarlem (1990), 32-48.
H.Pijl, H.P.F. Koppeschaar, F.L.A. Willekens, I Op de Kamp, H.D. Veldhuis, A.E. Meinders
Effect of serotonin re-uptake inhibition by fluoxetine on body weight and spontaneous food choice in
obesity
Int J Obesity 1991; 15: 237-242.
L. Vermulst, C. Vervoorn, A. Boelens-Quist, H.P.F. Koppeschaar, W. Erich, J.H.H. Thijssen, W. de
Vries Analysis of seasonal training volume and working capacity in elite female rowers
Int J Sports Medicine 1991; 12: 567-572.
L.B. Creemers, P.M.J. Zelissen, J.W. van 't Verlaat, H.P.F. Koppeschaar
Prolactinoma and body weight: a retrospective study
Acta Endocrinol 1991; 125: 392-396.
H. Pijl, H.P.F. Koppeschaar, P.M.J. Zelissen, A.E. Meinders
Regulatie van de voedselopneming en behandeling van vetzucht met centraal werkende serotonerge
medicamenten
Ned Tijdschr Geneeskd 1991; 135: 700-703.
Timmer R., J.C. Koningsberger, D.W. Erkelens, J.H.H. Thijssen, C.J.M. Lips, H.P.F. Koppeschaar
No effect of the long-acting somatostatin analogue octreotide in patients with insulinoma
Neth J Med 1991; 38: 199-203.
Vervoorn C., H.P.F. Koppeschaar, W.R. de Vries
Human growth-hormone (GH) respons to corticotropin-releasing-hormone (CRH) stimulation as a
function of training
Clin Exp Endocrinol 1991; 10: 265-268.
Curriculum Vitae – Hans Koppeschaar
8
Vervoorn C., H.P.F. Koppeschaar, W.R. de Vries, H.A. Keizer
A training dependent prolactin (PRL) response to corticotropin-releasing-hormone (CRH) stimulation
Clin Exp Endocrinol 1991; 10: 269-272.
J.P.T.Span, A.E.Meinders, P. P Koopmans, P.M.J.Zelissen, H.P.F.Koppeschaar, H.Pijl Regulatie van
de voedselopneming en de behandeling van vetzucht met centraal werkende serotonerge
medicamenten. Ned Tijdschr Geneeskd 1991;135:1100-1101
P.M.J. Zelissen, H.P.F. Koppeschaar, D.W. Erkelens, J.H.H. Thijssen
Beta-endorphin and adrenocortical function in obesity
Clin Endocrinol 1991; 35: 369-372.
P.M.J. Zelissen, H.P.F. Koppeschaar, C.J.M. Lips, W.H.L. Hackeng
Calcitonine Gene-Related Peptide in human obesity
Peptides 1991; 12: 861-863.
P.M.J. Zelissen, H.P.F. Koppeschaar, J.H.H. Thijssen, D.W. Erkelens
Beta-endorphin and insulin/glucose responses to different meals in obesity
Horm Res 1991; 36: 32-35.
Breslau-Siderius E.J., J. Toonstra, J.A. Baart, H.P.F. Koppeschaar, J.A. Maassen, F.A. Beemer
Ectodermal dysplasia, lipoatrophy, diabetes mellitus and amasta, a second case of the AREDYLD
syndrome
Am J Med Genet 1992; 44: 347-377.
Gispen-de Wied C.C., H.G.M Westenberg, H.P.F. Koppeschaar, J.H.H. Thijssen, J.M. van Ree
Stimulation of the pituitary-adrenal axis with a low dose [Arg8]-vasopressin in depressed patients and
healthy subjects
Eur J Neuropsychopharmacol 1992; 2: 411-419.
Koppeschaar H.P.F., C.D. ten Horn, J.H.H. Thijssen, M.D. Page, C. Dieguez, M.F. Scanlon
Differential effects of arginine on growth hormone releasing hormone and insulin induced growth
hormone secretion
Clin Endocrinol 1992; 36: 487-490.
Koppeschaar H.P.F., J.H.H.Thijssen
Laboratoriumonderzoek bij functieafwijkingen van de schildklier
In: Een handleiding voor laboratoriumdiagnostiek in de eerste lijn, J.P.Persijn, hoofdred. - SAN (1992):
98-113.
Koppeschaar H.P.F.
Hyperparathyreoidie, Hypoparathyreoidie, hypercalciemie
In: A.E. Meinders, M.A. Boogaars, A.J.M. Donker, D.W. Erkelens, M.A.D.H. Schalekamp, P. Vermeij
(eds) Therapie in de interne geneeskunde. Bunge, 1992: 452-461.
Koppeschaar H.P.F.
Het syndroom van Cushing
In: A.E. Meinders, M.A. Boogaars, A.J.M. Donker, D.W. Erkelens, M.A.D.H. Schalekamp, P. Vermeij
(eds) Therapie in de interne geneeskunde. Bunge, 1992: 461-465.
Koppeschaar H.P.F.
Primaire bijnierschorsinsufficientie (ziekte van Addison)
In: A.E. Meinders, M.A. Boogaars, A.J.M. Donker, D.W. Erkelens, M.A.D.H. Schalekamp, P. Vermeij
(eds) Therapie in de interne geneeskunde. Bunge, 1992: 465-468.
Koppeschaar H.P.F.
Juveniele polyglandulaire insufficientie
In: A.E. Meinders, M.A. Boogaars, A.J.M. Donker, D.W. Erkelens, M.A.D.H. Schalekamp, P. Vermeij
(eds) Therapie in de interne geneeskunde. Bunge, 1992: 468-469.
Curriculum Vitae – Hans Koppeschaar
9
Koppeschaar H.P.F.
Feochromocytoom
In: A.E. Meinders, M.A. Boogaars, A.J.M. Donker, D.W. Erkelens, M.A.D.H. Schalekamp, P. Vermeij
(eds) Therapie in de interne geneeskunde. Bunge, 1992: 470-473.
Koppeschaar H.P.F.
Primair hyperaldosteronisme (syndroom van Conn)
In: A.E. Meinders, M.A. Boogaars, A.J.M. Donker, D.W. Erkelens, M.A.D.H. Schalekamp, P. Vermeij
(eds) Therapie in de interne geneeskunde. Bunge, 1992: 473-476.
Koppeschaar H.P.F.
Endocriene tumoren van het pancreas
In: A.E. Meinders, M.A. Boogaars, A.J.M. Donker, D.W. Erkelens, M.A.D.H. Schalekamp, P. Vermeij
(eds) Therapie in de interne geneeskunde. Bunge, 1992: 476-487.
Koppeschaar H.P.F.
MEN-syndroom
In: A.E. Meinders, M.A. Boogaars, A.J.M. Donker, D.W. Erkelens, M.A.D.H. Schalekamp, P. Vermeij
(eds) Therapie in de interne geneeskunde. Bunge, 1992: 487.
Leeuwen J.S.van, H.P.F. Koppeschaar, W.J. Kop, E.R. te Velde, W.H.L. Hackeng, A.A. Haspels
Calcitonin gene-related peptide, the menstrual cycle and premenstrual syndrome
Gynecol Endocrinol 1992; 6: 199-204.
Lips C.J.M., H.P.F. Koppeschaar, M.J.H. Berends, J.M. Jansen-Schillhorn van Veen, A. Struyvenberg,
Th.J.M.V. van Vroonhoven
The importance of screening for the MEN-1 syndrome; diagnostic results and clinical management
Henry Ford Hosp Med J 1992; 40: 171-173.
Roelen C.A.M., G.H. Donker, J.H.H. Thijssen, H.P.F. Koppeschaar, M.A. Blankenstein
High affinity growth hormone binding protein in plasma of patients with acromegaly and the effect of
octreotide treatment
Clin Endocrinol 1992; 37: 373-378.
Saris W.H.M., J.C. Seidell, H.P.F. Koppeschaar (eds)
Abstracts IV European Congress on Obesity
Int J Obesity 1992; 16 (suppl.16): 1-75.
Slee P.H.Th.J., H.P.F. Koppeschaar, J.W.R. Nortier, J.A. Raymakers
Hypercalciemie en maligniteiten; pathogenese, differentiaaldiagnose en behandeling
Ned Tijdschr Geneeskd 1992; 136: 1243-1247.
Vasen H.F.A., M. van der Feltz, F. Raue, A. Nieuwenhuyzen Kruseman, H.P.F. Koppeschaar, G.
Pieters, F. Seif, W.F. Blum, C.J.M. Lips
The natural course of multiple endocrine neoplasia type IIb. A study of 18 cases
Arch Intern Med 1992; 152: 1250-1253.
Vervoorn C., L.J.M. Vermulst, A.M. Boelens-Quist, H.P.F. Koppeschaar, W.B.M. Erich, J.H.H.
Thijssen, W.R. de Vries
Seasonal changes in performance and free testosterone/cortisol ratio (FTCR) of elite female rowers
Eur J Appl Physiol 1992; 63: 14-21.
Vroonhoven van Th.J.M.V., M.S. van Leeuwen, H.P.F. Koppeschaar
Chirurgische behandeling van het insulinoom: het belang van intra-operatieve echografie
Ned Tijdschr Geneeskd 1992; 136: 910-914.
Curriculum Vitae – Hans Koppeschaar
10
P.M.J. Zelissen, H.P.F. Koppeschaar, J.H.H. Thijssen, D.W. Erkelens
Growth hormone secretion in obese patients with non-insulin dependent diabetes mellitus: effect of
weight reduction and of fluoxetine treatment.
Diab Nutr Metabol 1992; 5: 131-135.
P.M.J. Zelissen, H.P.F. Koppeschaar, J.H.H. Thijssen, D.W. Erkelens
TSH and prolactin secretion in obesity: influence of weight reduction and of treatment with the
serotoninergic drug dexfenfluramine.
Exp & Clin Endocrinol 1992; 11: 221-226
Smeets M, Panhuysen G., Tuiten A., Everaerd W., Koppeschaar H. A meta-analysis on body
size estimation experiments in anorexia nervosa Neuroendocrinology Letters 14,3101,1992
Brink H.R., M.A. Blankenstein, H.P.F. Koppeschaar, J.W.J. Bijlsma
Influence of disease activity on steroid hormone levels in peripheral blood of patients with rheumatroid
artritis
Clin Exp Rheumatol 1993; 11: 649-652.
M. van Buren, T.J. Rabelink, H.P.F. Koppeschaar, H.A. Koomans
The role of glucocorticoid in excretion of an acute potassium load in patients with Addison's disease
and panhypopituitarism
Kidney Int 1993; 44: 1130-1138.
K.P. Bouter, R. Diepersloot, M. Sprenger, M. Helsloot, H.P.F. Koppeschaar, J. Hoekstra, D.W.
Erkelens, N. Masurel
Influenza vaccination in patients with Graves' disease: clinical reaction, immunogenicity and protection
Eur J Int Med 1993; 4: 137-171.
Gispen-de Wied C.C., F.W. Kok, H.P.F. Koppeschaar, H.J. Wynne, H.G.M Westenberg, J.H.H.
Thijssen, J.M. van Ree
Stimulation of the pituitary-adranel system with graded doses of CRH and low dose vasopressin
infusion in depressed patients and healthy subjects: a pilot study
Eur J Neuropsychopharmacol 1993; 3: 533-541.
Koppeschaar H.P.F.
Pathogenesis and pharmocological treatment of obesity in type II Diabetes
Diab Rev 1993; 2: 10-13.
Lips C.J.M., H.P.F. Koppeschaar, J. Jansen-Schillhorn van Veen, J.M. Struyvenberg, Th.J.M.V. van
Vroonhoven
Multiple endocrine neoplasia type 1 syndrome: strategies of early detection and treatment
Curr Pract Surg 1993; 5: 80-85.
Pijl H., H.P.F. Koppeschaar, A.F. Cohen, J.A. Jestra, H.C. Schoemaker, M. Frölich, W. Onkenhout,
A.E. Meinders
Evidence for brain serotonin-mediated control of carbohydrate consumption in normal weight and
obese humans
Int J Obesity 1993; 17: 513-520.
Pijl H., H.P.F. Koppeschaar, F.L.A. Willekens, M. Frölich, A.E. Meinders
The influence of serotonergic neurotransmission on pituitary hormone release in obese and non-obese
females
Acta Endocrinol 1993; 128: 319-324.
Schagen van Leeuwen J.H., E.R. te Velde, H.P.F. Koppeschaar, W.J. Kop, J.H.H. Thijssen, J.M. van
Ree, A.A. Haspels
Review: Is premenstrual syndrome an endocrine disorder?
J Psychosom Obstet Gynaecol 1993; 14: 91-109.
Curriculum Vitae – Hans Koppeschaar
11
M.F.J., K.J. van Erpecum, H.P.F. Koppeschaar, W.J. de Bruin, J.B.M.J. Jansen, C.B.H.W. Stolk
Lamers, G.P. van Berge Henegouwen
Postprandial gall bladder mobility and hormone release during intermittent and continuous subcutaneous octreotide treatment in acromegaly
Gut 1993; 34: 808-813.
A. Tuiten, G. Panhuijsen, H.P.F. Koppeschaar, P.M.J. Zelissen, P. Krabbe, W. Everaerd
The paradoxical nature of sexuality in anorexia nervosa
J Sex & Marital Therapy 1993; 19: 259-275.
Tuiten, A., A. Jansen, H.P.F. Koppeschaar
Anorexia, bulimia and exercise-induced amenorrhea: multidisciplinary approach
In: Current Therapy in Endocrinology and Metabolism, 5th. ed. (1993), Hypothalamic disease, C.
Wayne Bardin, Ed., New York: BC Decker Inc: 12-15.
Visser M., J.C. Seidell, H.P.F. Koppeschaar, P. Smits
The effect of fluoxetine on body weight, body composition and visceral fat accumulation
Int J Obesity 1993; 17: 247-253.
Garcia, M.B., H.P.F. Koppeschaar, C.J.M. Lips, J.H.H. Thijssen, E.P. Krenning
Acromegaly and hyperprolactinaemia in a patient with polyostotic fibrous dysplasia: dynamic
endocrine studies and treatment with somatostatin analogue octreotide
J Endocrinol Invest 1994; 17: 59-65.
Leenen, R., K. van der Kooy, J.C. Seidell, P. Deurenberg, H.P.F. Koppeschaar
Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight
loss therapy.
J Clin Endocrinol Metab 1994; 78: 1515-1521.
Page, M.D., C. Dieguez, R. Valcavi, H.P.F. Koppeschaar, M.F. Scanlon
Growth hormone releasing hormone 1-44 NH2 and 1-40 OH levels in normal subjects during growth
hormone stimulation tests. Clin Endocrinol 1994; 40: 97-102.
Tuiten, A., G. Panhuyzen, H.P.F. Koppeschaar
Mood, food and the menstrual cycle: the ratio of tryptophan to other large neutral aminoacids following
stress J Serotonin Res 1994; 1: 151-169.
Vasen, H.F.A., K.J. Erpecum, F. Roelfsema, F. Raue, H.P.F Koppeschaar
Increased prevalence of colonic adenomas in patients with acromegaly
Eur J Endocrinol 1994; 131: 235-237.
Visser, M., J.C. Seidell, H.P.F. Koppeschaar
No specific effect of fluoxetine treatment on fasting glucose, insulin, lipid levels and blood pressure in
healthy men with abdominal obesity
Obesity Res 1994; 2: 152-160.
Zonneveld, P. van, E.R. te Velde, H.P.F. Koppeschaar
Low luteal phase serum progesterone levels in regularly cycling women are predictive of subtle
ovulation disorders
Gynecol Endocrinol 1994; 8: 169-174.
M.L. Drent, P.M.J. Zelissen, H.P.F. Koppeschaar, A.C. Nieuwenhuyzen Kruseman, J.A. Lutterman,
E.A. van der Veen
The effect of dexfenfluramine on eating habits in a Dutch ambulatory android overweight population
with an overconsumption of snacks
Int J Obesity 1995; 19: 299-304.
Curriculum Vitae – Hans Koppeschaar
12
Y.E.M. Snel, R.J.M. Brummer, E. Bol, M.E. Doerga, P.M.J. Zelissen, M.L. Zonderland, P. Boer, H.A.
Koomans, H.P.F. Koppeschaar
Direct assessment of extra cellular water volume by the bromide dilution method in growth hormonedeficient adults
Eur J Clin Invest 1995; 25: 708-714.
Y.E.M. Snel, R-J.M. Brummer, M.E. Doerga, P.M.J. Zelissen, C.J.G. Bakker, M.J. Hendriks, H.P.F.
Koppeschaar
Adipose tissue, assessed by magnetic resonance imaging, in growth hormone-deficient adults: the
effect of growth hormone replacement and a comparison with healthy controls
Am J Clin Nutr 1995; 61: 1290-1294.
Y.E.M. Snel, R-J.M. Brummer, M.E. Doerga, P.M.J. Zelissen, H.P.F. Koppeschaar
Validation of extracellular water determination by bioelectrical impedance analysis in growth hormonedeficient adults
Ann Nutr Metabol 1995; 39: 242-250.
Y.E.M. Snel, R-J.M. Brummer, M.E. Doerga, P.M.J. Zelissen, H.P.F. Koppeschaar
Energy and macronutrient intake in growth hormone-deficient adults: the effect of growth hormone
replacement
Eur J Clin Nutr 1995; 49: 492-500.
Y.E.M. Snel, M.E. Doerga, R-J.M. Brummer, P.M.J. Zelissen, M.J. Zonderland, H.P.F. Koppeschaar
Resting metabolic rate, body composition and related hormonal parameters in growth hormonedeficient adults before and after growth hormone replacement therapy
Eur J Endocrinol 1995; 133: 445-450.
Y.E.M. Snel, M.E. Doerga, R-J.M. Brummer, P.M.J. Zelissen, H.P.F. Koppeschaar
Adipose tissue, assessed by magnetic resonance imaging, serum lipids and insulin in growth
hormone-deficient adults: the effect of growth hormone replacement
Arterioscler Thromb Vascul Biol 1995; 15: 1543-1548.
H. Pijl, A.F. Cohen, R.J. Verkes, H.P.F. Koppeschaar, J.A. Iestra, H.C. Schoemaker, M. Frolich, W.
Onkenhout, A.E. Meinders Plasma amino acid ratios related to brain serotonin synthesis in response
to food intake in bulimia nervosa Biol Psychiatry 1995; 38: 659-668.
M.E. Doerga, H.P.F. Koppeschaar, P.M.J. Zelissen, Y.E.M. Snel
Groeihormoon-substitutietherapie bij volwassenen met groeihormoon-deficiëntie
Patient Care 1995; 22: 45-59.
P. v. Zonneveld, H.P.F. Koppeschaar, et al.
A patient with a progesteron producing adrenal adenoma who presented with primary amenorrhoea
Gynecol Endocrinol 1995; 9: 1-6.
M.L. Drent, H.P.F. Koppeschaar
Eating habits of obese patients in The Netherlands: a comparison between various subgroups and the
general Dutch population
Metabolism 1995; 44: 46-49.
M.F.J. Stolk, K.J. van Erpecum, H.P.F. Koppeschaar, et al.
Effect of octreotide on fasting gall bladder emptying, antroduodenal motility, and motilin release in
acromegaly
Gut 1995; 36: 755-760.
A. Tuiten, G. Panhuijsen, H.P.F. Koppeschaar, et al.
Stress, serotonergic function and mood in users of oral contraceptives
Psychoneuroendocrinol 1995; 20: 323-334.
Curriculum Vitae – Hans Koppeschaar
13
Th.J.M.V. v. Vroonhoven, A. van Dalen, H.P.F. Koppeschaar, S.A.Duursma
Gunstige resultaten van minimaal invasieve chirurgie bij de behandeling van primaire
hyperparathyreoidie
Ned Tijdschr Geneeskd 140:304-308, 1996.
A. Tuiten, E. Laan, G. Panhuijsen, W. Everaerd, E.H.F. de Haan, H.P.F. Koppeschaar, P. Vroon
Discrepancies between genital responses and subjective sexual functioning during testosterone
substitution in women with hypothalamic amenorrhoea
Psychosom Med 58:234-241, 1996.
C.O. van Waveren Hogervorst, H.P.F. Koppeschaar, P.M.J. Zelissen, C.J.M. Lips, B.M. Garcia
Cortisol secretory patterns in Cushing's disease and response to cyproheptadine treatment
J Clin Endocrinol Metab 81:652-655, 1996.
C.O. van Waveren Hogervorst, H.P.F. Koppeschaar, P.M.J. Zelissen, C.J.M. Lips, B.M. Garcia
Cortisol secretory patterns in Cushing’s disease and surgical, physiological and clinical aspects.
Eur J. Clin Invest. 1196;26:613-624, 1996.
C.A.M. Roelen, H.P.F. Koppeschaar, W. de Vries, P.M.J. Zelissen, Y.E.M. Snel, M.E. Doerga, J.H.H.
Thijssen, M.A. Blankenstein,
High affinity growth hormone-binding protein, insulin like growth factor-I and insulin-like growth factorbinding protein-3 in adults with growth hormone deficiency
Eur J Endocrinol 135:82-86, 1996.
M.L. Drent, P.M.J. Zelissen, H.P.F. Koppeschaar, A.C. Nieuwenhuyzen Kruseman, J.A. Lutterman,
E.A. van der Veen
Het effect van dexfenfluramine op de eetgewoonten van een polikliniekpopulatie met een androïd type
overgewicht en overmatige consumptie van tussendoortjes
Ned Tijdschr Geneeskd 140:1642-1646, 1996.
H.P.F.Koppeschaar Regulatie en secretie van groeihormoon(GH): effecten op lichaamssamenstelling
en metabolisme, in het bijzonder bij GH deficiente volwassenen. Ned Tijdschr Klin Chem 1997, vol 22,
no 3, 93.
J.M.H. de Klerk, J.W. van Isselt, A. van Dijk, M.E. Hakman, F.A. Pameijer, H.P.F. Koppeschaar,
P.M.J. Zelissen, J.P.J. van Schaik, P.P. van Rijk
Iodine-131 therapy in sporadic non-toxic goitre: volume reduction measured by CT and relationship
between CT and scintigraphic measurements
J Nucl Med 38:372-376, 1997.
C.A.M. Roelen, W. de Vries, H.P.F. Koppeschaar, C. Vervoorn, J.H.H. Thijssen, M.A. Blankenstein
Plasma insulin-like growth factor-1 and high affinity growth hormone-binding protein levels increase
after two weeks strenuous physical training
Int J Sports Med 18:238-241, 1997.
A. Nooitgedagt, H.P.F. Koppeschaar, W. de Vries, A. Sidorowicz, L.J. Klok, C. Dieguez, F. Mallo
Influence of endogenous cholinergic tone and growth hormone-releasing peptide-6 (GHRP-6) on
exercise-induced growth hormone release.
Clin Endocrinol 46:195-202, 1997.
W.D. van Marken Lichtenbelt, Y.E.M. Snel, R.J.M. Brummer, H.P.F. Koppeschaar
Deuterium and bromide dilution, and bio-impedence spectrometry independently show that growth
hormone deficient adults have an enlarged extra-cellular water compartment related to intracellular
water.
J Clin Endocrinol Metab 82:907-912, 1997.
C.A.M. Roelen, H.P.F. Koppeschaar, W.R. de Vries, Y.E.M. Snel, M.E. Doerga, P.M.J. Zelissen,
J.H.H. Thijssen, M.A. Blankenstein
Visceral adipose tissue is associated with circulating high affinity growth hormone-binding protein
J Clin Endocrinol Metab 82:760-765, 1997.
Curriculum Vitae – Hans Koppeschaar
14
C.J.M. Lips, H.P.F. Koppeschaar, J.W.M. Höppener, R. van Tooren, H.P.H. Neumann
Multiple endocrine neoplasia type 1 (MEN 1) Hormonal hypertension
Wydawnictwo Naukowe PWN, Warszawa 1997;275-291
R. Braams, H.P.F. Koppeschaar, H.D.W.M. van de Pavoordt, Th.J.M.V. van Vroonhoven
Adrenocortical function in patients with a ruptured aneurysm of the abdominal aorta
Intensive Care Medicine 24:124-127, 1998.
C.R. Markus, G. Panhuyzen, A. Tuiten, H.P.F. Koppeschaar, D. Fekkes, M.L. Pieters
Does carbohydrate-rich, protein-poor food prevent a deterioration of mood and cognitive performance
of stress-prone subjects when subjected to a stressful task?
Appetite 31(1):49-65, 1998.
Lars Sjöstrom, Aila Rissanen, Teis Andersen, Mark Boldrin, Alain Golay, Hans.P.F. Koppeschaar,
Michel Krempf, for the European Multicentre Orlistat Study Group.
Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese
patients, The Lancet , 352:167-173, 1998.
Jack van Honk, Adriaan Tuiten, Marcel van den Hout, Hans Koppeschaar, Jos Thijssen, Edward de
Haan, and Rien Verbaten. Baseline salivary cortisol levels and preconscious selective attention for
threat, Psychoneuroendocrinology 23(7):741-747, 1998.
Vos, P.E., H.P.F. Koppeschaar, W.R., de Vries, and J.H.J. Wokke: Insulin-like growth factor-1: clinical
studies. Drugs of Today, 34(1): 79-90, 1998
Roelen, C.A.M., H.P.F. Koppeschaar, W.R. de Vries, M.E. Doerga, Y.E.M. Snel, E. Bol, P.M.J.
Zelissen, J.H.H. Thijssen, M.A. Blankenstein: Plasma growth hormone-binding protein (GHBP), body
fat mass and plasma insulin-like growth factor (IGF)-binding protein-3 predict the GHBP response to
GH therapy in adult GH-deficiency syndrome. Metabolism 48(3):1-5, 1999.
Aleman A., H.J.J. Verhaar, E.H.F. de Haan, W.R. de Vries, M.M. Samson, M.L. Drent, E.A. van der
Veen, H.P.F. Koppeschaar: Insulin-like growth factor-1 and cognitive function in healthy older men.
Journal of Clinical Endocrinology and Metabolism 84:471-475, 1999.
Peino,R, Leal,A, Garcia-Mayor,R.V, Cordido,F, Micic,D, Koppeschaar,H.P.F, Dieguez,C,
Casanueva,F.F,. The use of growth hormone (GH) secretagogues in the diagnosis of GH deficiency in
humans. Growth Hormone & IGF Research 9,101-105,1999.
Castro Cabezas M., P.M.J. Zelissen, G.H. Jansen, A.P.G. Van Gils, and H.P.F. Koppeschaar:
Acromegaly: report of two patients with an unusual presentation. The Netherlands Journal of Medicine
54:163-166, 1999.
Linda M.C. Hempenius, P.S. van Dam, J.J.M. Marx and H.P.F. Koppeschaar, Mineralocorticoid status
and endocrine dysfunction in severe haemochromatosis. J. Endocrinol. Invest. 22:369-376, 1999.
P.van Zonneveld, H.P.F. Koppeschaar, J.D.F. Habbema, B.C.J.M. Fauser, E.R. te Velde. Diagnosis of
subtle ovulation disorders in subfertile women with regular menstrual cycles: cost-effective clinical
practice? Gynecol. Endocrinol, 13:42-47, 1999.
J.van Honk, A.Tuiten, R. Verbaten, M. van den Hout, H.P.F. Koppeschaar, J.H.H. Thijssen, E. de
Haan. Correlations among salivary testosterone, mood, and selective attention to treat in humans,
Hormones and Behavior 36:17-24, 1999.
De Klerk J.M.H., B.M. Goslings, H.P.F. Koppeschaar, et al., Behandeling van het gedifferentieerde
schildkliercarcinoom met jodium-131: op weg naar een landelijke consensus Tijdschrift voor Nucleaire
Geneeskunde, 1999 , nr. 4., 139-149.
Curriculum Vitae – Hans Koppeschaar
15
Bengtsson B-Å., Koppeschaar H.P.F., Abs R, Bennmarker H, Hernberg-Stahl E, Westberg B, Wilton
P, Monson J P, Feldt-Rasmussen U, Wuster C.et al., Growth hormone replacement therapy is not
associated with any increase in mortality. J Clin Endocrinol Metab 1999 ;84:4291-2
Bengtsson B-Å., R. Abs, H. Bennmarker, et al., on behalf of the KIMS Study Group and the KIMS
International Board.(Koppeschaar H.P.F.) Pharmacia and Upjohn International Metabolic Database.
The effects of treatment and the individual responsiveness to Growth Hormone(GH) replacement
therapy in 665 GH-deficient adults. Journal of Clinical Endocrinology and Metabolism,1999, 84(11):
3929-3934.
Abs R.,B-A Bengtsson,E Hernberg-Stahl, et al., on behalf of the KIMS Study Group and the KIMS
International Board.(Koppeschaar H.P.F.) Pharmacia and Upjohn International Metabolic
Database.GH replacement in 1034 growth hormone deficient hypopituitary adults: demographic and
clinical characteristics, dosing and safety. Clinical Endocrinology, 1999 , 50: 703-713.
P. van Zonneveld, G. Scheffer, H.P.F. Koppeschaar, B.C.J.M. Fauser,F.J. Broekmans and E.R. te
Velde. Hormone patterns after induction of ovulation with clomiphene citrate: an age-related
phenomenon. Gynecol. Endocrinol. 1999 ; 13::259-265.
M.P.M.Stokkel, J.H.M. de Klerk, P.M.J. Zelissen, H.P.F. Koppeschaar, P.P. van Rijk, Fluorine-18
fluorodeoxyglucose dual-head positron emission tomography in the detection of recurrent
differentiated thyroid cancer: preliminary results, European Journal of Nuclear Medicine,
1999,26,12,1606-1610.
Sjostrom L, Rissanen A, Andersen T, Boldrin M, Golay A, Koppeschaar H, Krempf M; European
Multicenter Orlistat Study Group. Randomized placebo-controlled trial of orlistat for weight loss and
prevention of weight regain in obese patients. Ter Arkh 2000; 72(8): 50-4. Russian.
Aleman A., W.R. de Vries, E.H.F. de Haan, H.J.J. Verhaar, M.M. Samson, H.P.F. Koppeschaar: Agesensitive cognitive function, growth hormone, and insulin-like growth factor-1 plasma levels in healthy
older men. Neuropsychobiology :2000, 41 (2), 73-78 .
A.Tuiten, J.van Honk, H.P.F. Koppeschaar, C.Bernaards, J.H.H. Thijssen, R. Verbaten. Time Course
of Effects of Testosterone Administration on Sexual Arousal in Women, Arch Gen Psychiatry, 2000;
57:149-154.
J. W. van Isselt, J.M.H. de Klerk, H.P.F. Koppeschaar, P.P. van Rijk. Iodine-131 uptake and turnover
rate varying over short time intervals in Graves' disease.Nuclear Medicine Communications 2000, 21,
609-616.
Hans.C.M. Maas, Wouter.R. de Vries, Inge Maitimu, Eduard. Bol, Cyril.Y. Bowers, and Hans.P.F.
Koppeschaar: Growth hormone responses during strenuous execise: the role of GH-releasing
hormone and GH-releasing peptide--2.Medicine & Science in Sports & Exercise,2000, Vol.32, no 7,
1226-1232.
P. Wilton and H.P.F. Koppeschaar. Safety of growth hormone replacement in adults. In: GH
replacement in Adults. The first 5 years of KIMS. (eds. B-A Bengtsson and J.P. Monson). Oxford
PharmaGenesis Ltd, 2000, 182-190.
Monson J.P., Abs R., Bengtsson B-A, et al, on behalf of the KIMS Study Group and the KIMS
International Board(Koppeschaar H.P.F.) Pharmacia and Upjohn International Metabolic Database.
Growth Hormone deficiency and replacement in elderly hypopituitary adults. Clin Endocrinol (2000)
53, 281-289.
S. van Dam, A. Aleman, W.R. de Vries, J.B. Deijen, E.A. van der Veen, E.H.F. de Haan and H.P.F.
Koppeschaar Growth hormone, insulin-like growth factor-1 and cognitive function in adults. Growth
Hormone & IGF Research , 2000, Supplement B, S69-S73
Curriculum Vitae – Hans Koppeschaar
16
J.M.H. de Klerk, B. de Keizer, P.M.J. Zelissen, C.M.J. Lips and H.P.F. Koppeschaar
Fixed dosage of 131J for remnant ablation in patients with differentiated thyroid carcinoma without
Pre-ablative diagnostic 131J scintigraphy. Nuclear Medicine Communications, 2000, 21, 529-532
De Vries, W.R., A.T.M. Bernards, M.H. de Rooij, and H.P.F. Koppeschaar: Dynamic exercise
discloses different time-related responses in stress hormones. Psychosomatic Medicine, 2000,
62:866-872.
De Vries, W.R., H.P.F. Koppeschaar, E. Bol, C.A.M. Roelen, G.H. Donker, M.E. Doerga, M. OsmanDualeh, and Y.E.M. Snel: Intersubject responsiveness of high-affinity growth hormone (GH)-binding
protein (GHBP) to long-term GH replacement therapy, J Endocrinol Invest. 23: 449-459, 2000.
Verhaar, H.J.J., M.M. Samson, A. Aleman, W.R. de Vries, P.L. de Vreede and H.P.F. Koppeschaar:
The relationship between muscle function and circulating anabolic hormones in healthy elderly men.
The Aging Male, 2000 ; 3: 1-6.
Aleman, A., H.J.J. Verhaar, E.H.F. de Haan, M.M. Samson, W.R. de Vries, and H.P.F. Koppeschaar:
Relationship between physical and cognitive function in healthy older men: a role for aerobic power? J
Am Geriatr Soc, 2000; 48:104-105.
M. Ph. Mourits, L. van Kempen- Harteveld, M.B. Garcia-Garcia, H.P.F. Koppeschaar, L. Tick, C.B.
Terwee. Radiotherapy for Graves' orbitopathy: randomized placebo- controlled study The Lancet,
2000, 355, 1505-1519
Vera Popovic, Alfonso Leal, Dragan Micic, Hans P.F. Koppeschaar, Elena Torres, Concha Paramo,
Sandra Obradovic, Carlos Dieguez, Felipe F. Casanueva. Combined administration of growth
hormone (GH) releasing hormone with GH-releasing peptide-6 as an effective diagnostic test of GH
deficiency in adults. The Lancet 2000, 356:1137-42.
Simon A., H.P.F. Koppeschaar,J.F.M. Roijers, J.W.M. Hoppener C.J.M. Lips.
Pseudohypoparathyroidism:type Ia: Albright hereditary osteodystrophy : a model for research on G
protein coupled receptors and genomic imprinting.
Neth J Med, 2000 ;56:100-109.
Van Honk J., A. Tuiten, M. van den Hout, H.P.F. Koppeschaar, J.H.H. Thijssen, E. de Haan, R.
Verbaten: Conscious and preconscious selective attention to social threat: different neuroendocrine
response patterns. Psychoneuroendocrinology, 25 (2000) 577-591.
Th.B. Twickler, H.W. Wilmink, P.C.N.J. Schreuder, M. Castro-Cabezas, P.S.van Dam, H.P.F.
Koppeschaar, D.W. Erkelens, G.M. Dallinga-Thie
Growth hormone treatment decreases postprandial remnant-like particle cholesterol concentration
and improves endothelial function in adult –onset growth hormone deficiency.
J. Clin Endocrinol. Metab, 2000, 85 (12): 4683-4689.
P.S. van Dam, W.R. de Vries, H. Smid, M. Niesink, E. Bolscher,E.J. Waasdorp, C. Dieguez, F.F.
Casanueva and H.P.F. Koppeschaar Growth Hormone –releasing hormone and growth hormone
releasing peptide 2 stimulated growth hormone secretion in elderly men after reduction of free fatty
acids by acipimox. J.Clin Endocrinol Metab, 2000, 85,12,4706-4711.
A.C. Lambers, H.P.F. Koppeschaar, J.W. van Isselt, W. Slob, R.C. Schothorst, Tj. T. Mensinga, J.
Meulenbelt The effect of nitrate on the thyroid gland function in healthy volunteers: 4-week oral
toxicity study RIVM report, 235802015, Bilthoven: RIVM,2000,1-61
H.P.F. Koppeschaar
The literature of Medicine: Reviews and notes
Human Growth Hormone, Research and Practice
The Netherlands Journal of Medicine, 2000 ; 57:34-35
Curriculum Vitae – Hans Koppeschaar
17
Markus C.R., B. Olivier, G. Panhuysen, J. van der Gugten, M.S. Alles, A. Tuiten, H. Westenberg, D.
Fekkes, H.P.F. Koppeschaar, and E. de Haan. The bovine protein a-lactalbumin increases the plasma
ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain
serotonin activity, reduces cortisol concentration, and improves mood under stress. Am J Clin Nutr
71(6): 1536-1544, 2000.
Markus, C.R., Panhuysen, G., Tuiten, A., Koppeschaar, H.P.F.,
Effects of food on cortisol and mood in vulnerable subjects under controllable and uncontrollable
stress Physiol Behav. 70(3-4): 333-342, 2000.
J.van Honk, A.Tuiten, M. van den Hout, H.P.F. Koppeschaar, J.H.H. Thijssen, E. de Haan, R.
Verbaten. Conscious and preconscious selective attention to social threat: different neuroendocrine
response patterns. Psychoneuroendocrinology 25: 575-579, 2000.
Andre Aleman, Wouter R. de Vries, Hans.P.F. Koppeschaar, Mohamoud Osman-Dualeh, Harald.J.J.
Verhaar, Monique.M. Samson, Eduard. Bol, Edward.H.F. de Haan: Relationship between circulating
levels of sex hormones and insulin-like growth factor-1 and fluid intelligence in older men., Exp Aging
Res 2001, 27(3): 283-291
Wuster C., Abs R., Bengtsson B-A., et al., on behalf of the KIMS Study Group and the KIMS
International
Board (Koppeschaar H.P.F.) Pharmacia and Upjohn International Metabolic Database
The influence of growth hormone deficiency, growth hormone replacement therapy, and other aspects
of hypopituitarism on fracture rate and bone mineral density. Journal of Bone and Mineral Research
2001, 16(2): 398-405.
C.J.M. Lips, H.P.F. Koppeschaar. P.M.J. Zelissen, P.S. van Dam, J.M.H. de Klerk, B.A.
Zonnenberg, Th.J.M.V. van Vroonhoven. Tumoren van de endocriene klieren. In: Oncologie . Ed.
C.J.H. v.d. Velden, F.T. Bosman, D.J.Th Wagener. 6e herz. Druk, Bohn Stafleu, 2001 pp. 637-681.
Antonio Moschetta, Mark Stolk, Jens Rehfeld, Piero Portincasa, Hans.P.F. Koppeschaar, Peter
H.Th.J. Slee, Karel J. van Erpecum, Gerard P. van Berge Henegouwen. Severe impairment of
postprandial cholecystokinin release and gallbladder emptying and high risk of gallstone formation in
acromegalic patients during Sandostatin LAR, Aliment Pharmacol Ther 2001: 15(2): 181-185.
Bart de Keizer, Hans P.F. Koppeschaar, Pierre M.J. Zelissen, Cees J.M. Lips, Peter P. van Rijk, Aalt
van Dijk, John M.H. de Klerk. Efficacy of high therapeutic doses of Iodine--131 in patients with
differentiated thyroid cancer and detectable serum thyroglobulin.
Eur. J. Nuclear Med.2001 28(2):198-202
V.Popovic, A. Leal, H.P.F. Koppeschaar, C. Dieguez, and F.F. Casanueva. Adult growth hormone
deficiency, The Lancet 2001, 357: 308-309.
van Honk J,Tuiten A, Hermans E, Putman P, Koppeschaar H,Thijssen J,Verbaten R, van Doornen L
A single administration of testosterone induces cardiac accelerative responses to angry faces in
healthy young women Behav Neurosci 2001; 115(1): 238-244
Th. B. Twickler, G.M. Dallinga-Thie, P.M.J. Zelissen, H.P.F. Koppeschaar, D.W. Erkelens.
The atherogenic plasma remnant-like particle cholesterol concentration increased in the fasting and
postprandial state in active acromegalic patients Clin Endocrinol , 2001, 55(1): 69-75.
D.J.L.G. Schutter, J. van Honk, A.Tuiten, E. de Haan and H.P.F. Koppeschaar. Cortisol is inversely
related to prefrontal gamma coherence in healthy human subjects. J Neuropsychiatry Clin. Neurosci.
2001,13(4): 534-535
Hernberg-Stahl E., Luger A, Abs R, Bengtsson B A, Feldt-Rasmussen U, Wilton P,et al., and the KIMS
*
International Board (Koppeschaar H.P.F.), on behalf of the Kims Study Group Healthcare
Consumption Decreases in Paralell with Improvements in Quality of Life during GH Replacement in
Hypopituitary Adults with GH Deficiency. The Journal of Clinical Endocrinology and Metabolism, 2001:
86(11): 5277-5281
Curriculum Vitae – Hans Koppeschaar
18
Th. B. Twickler, H.C.M.T. Prinsen, W.R de Vries, H.P.F. Koppeschaar, and M.G.M. de Sain-van der
Velden. Analysis of the separate secretion of VLDL-1 and VLDL-2 by the liver will be a principal factor
in resolving the proatherogenic lipoprotein profile in hypopituitarism. J. Clin. Endocrinol. Metab. 2002,
87(4): 1907.
Ulla Feldt –Rasmussen, Roger Abs, Bengt-Ake Bengtsson, Helge Bennmarker, Margareta Bramnert,
Elizabeth Hernberg-Stahl, John P Monson, Bjorn Westberg, Patrick Wilton, Christian Wuster and the
KIMS International Board (Koppeschaar H.P.F.) on behalf of the KIMS Study Group Growth hormone
deficiency and replacement in hypopituitary patients previously treated for acromegaly and Cushing’s
disease, Eur. J. Endocrinol 2002, 146: 67-74
Th. B. Twickler, M.J.M. Cramer, G.M. Dallinga-Thie, W.R. de Vries, D.W. Erkelens, H.P.F.
Koppeschaar. Het atherosclerotisch proces aan de teugels van de GH/IGF-as? Tijdschr. Cardiol.J
Cardiol 2002, 14(2): 51-61
Th. B. Twickler, M.J.M. Cramer, H.P.F. Koppeschaar, W.R. de Vries, D.W. Erkelens.
Cardiovascular Endocrinology: a new dimension in medicine. The Lancet, 2002, 359: 799.
W.R. de Vries, S. Ait Abdesselam, T.J. Schers, H.C.M. Maas, M. Osman -Dualeh, I. Maitimu, and
H.P.F. Koppeschaar. Complete inhibition of hypothalamic somatostatin activity is only partially
responsible for the growth hormone response to strenuous exercise. Metabolism,2002, 51(9): 10931096
Schutter D.J., van Honk J, Koppeschaar H , Kahn R Cortisol and reduced interhemispheric coupling
between the left prefrontal and the right parietal cortex: J Neuropsychiatry Clin Neurosci. 2002, 14(1):
89-90
A. Leal, M. Lage, V. Popovic, E. Torres, H.P.F. Koppeschaar, C. Paramo, D. Micic, R. V. GarciaMayor, C. Dieguez, and F.F. Casanueva. A single growth hormone (GH) determination is sufficient for
the diagnosis of GH-deficiency in adult patients using the growth hormone releasin hormone plus
growth hormone releasing peptide-6 test. Clin. Endocrinol.2002; 57: 377-384
H. Snoek, S.H.M. van Gooszen, W. Matthys, H. Sigling, H.P.F. Koppeschaar, H. Westenberg, J.H. van
Engeland. Serotonergic functioning in children with oppositinal defiant disorder: sumatriptan challenge
study Biol Psychiatry.2002 15;51(4): 319-325
H.P.F.Koppeschaar, J.H.H. Thijssen
Laboratoriumonderzoek bij functieafwijkingen van de schildklier
SAN,Diagnostisch Handboek 2002,53-60.
Twickler TB, Cramer MJ, Koppeschaar HP, de Vries WR, Erkelens DW
Mortality in elderly patients with subclinical hyperthyroidism Lancet 2002,2;359, (9308):799
P.Sytze van Dam., Carlos Diequez., Fernando Cordido., Wouter.R de Vries., Bernard
F.E.Veldhuyzen., Felipe F.Casanueva and Hans.P.F.Koppeschaar
Diagnosis of growth hormone deficiency after pituitary surgery: the combined acipimox/GH-releasing
hormone test, Clin Endocrinology, (2003) 58, 156-162
Th. B. Twickler, M.J.M. Cramer, P.J. Senden, W.R. de Vries, H.P.F. Koppeschaar
Hormones et Coeur, Journal de Cardiologie 2003, 15,4, 117-121
Van Honk, J., Kessels, R.P.C., Putman, P., Jager, G., Koppeschaar, H.P.F., Postma A., Attentionally
modulated effects of cortisol and mood on memory for emotional faces in healthy young males
Psychoneuroendocrinology, 2003, 28(7): 941-948
W. R. de Vries, T.J. Schers,S. Ait Abdesselam, M. Osman-Dualeh, I. Maitimu and H. P. F.
Koppeschaar. Involvement of endogenous growth hormone-releasing hormone (GHRH) in the
exercise-related response of growth hormone, Int. J. Sports Med. 2003 ; 24: 208-211.
Curriculum Vitae – Hans Koppeschaar
19
Th.B.Twickler, E. Bruckert, M.J.M. Cramer, D.W. Erkelens, H.P.F. Koppeschaar
L’endocrinologie cardiovasculaire: un role pour l’axe hormone de croissance/insulin-like growth factor
dans le processus atherosklereux? Presse Med 2003, 32( 26) : 1238-1243
Th.B.Twickler, M.J. Cramer, P.Sytze van Dam, W.R. de Vries, D.W.Erkelens, H.P.F. Koppeschaar
Significant improvement of acromegaly-induced cardiomyopathy after normalisation of GH levels:
Case Report and Review The Endocrinologist 2003, 13, 3, 169-173
ThB.Twickler, M.J.M. Cramer, P.J. Senden, W.R. de Vries,DW Erkelens, H.P.F. Koppeschaar
Hormones and the Heart. Does the Cardiovascular System Need Growth Hormone in Adult Life ?
Neth Heart J, 2003, 11, 4, 151-152.
Bart de keizer, Boudewijn Brans, Anne Hoekstra, Pierre M.J. Zelissen, Hans P.F. Koppeschaar et al
Tumour dosimetry and response in patients with metestatic differentiated thyroid cancer using
Recombinant human thyrotropin before radioiodine therapy
Eur J Nucl Med Mol Imaging 2003, 30,3, 367- 373.
Th.B.Twickler, M.J.M. Cramer, G.M. Dallinga-Thie, M.J. Chapman, D.W. Erkelens and H.P.F.
Koppeschaar Adult-onset Growth Hormone Deficiency: Relation of Postprandial Dyslipidemia to
Premature Atherosklerosis J. Clin. Endocrinol. Metab. 2003, 88(6):2479-2488.
Th.B.Twickler, G.M. Dallinga-Thie, F.L.J. Visseren, W.R. de Vries, D.W. Erkelens, and H.P.F.
Koppeschaar. Induction of postprandial Inflammatory response in adult onset growth hormone
deficiency Is related to plasma remnant-like particle-cholesterol concentration J. Clin. Endocrinol.
Metab. 2003, 88(3):1228-1233.
Th.B.Twickler, M.J.M. Cramer, H.P.F. Koppeschaar. Unreaveling Reaven's Syndrome X: serum
insulin-like growth factor-I and cardiovascular disease
Circulation 2003 , 107(20): e 190-192
R.J. Huy, A.A. van Elburg, R. Sieders, E. Stevelmans, H.P.F. Koppeschaar, S.H.M. van Goozen, H.
van Engeland. Allopregnanolon en anorexia nervosa Tijdschrift voor Psychiatrie,45 (2003) 5, 243-250
M. Lijffijt, P.S. Van Dam, J.L. Kenemans, H.P.F. Koppeschaar, W.R. de Vries, M.L. Drent, A.
Wittenberg, C. Kemner Somatotrophic-axis deficiency affects brain substrates of selective attention in
childhood-onset growth hormone deficient patients Neuroscience Letters 353 (2) ( 2003) 123-126
Th.B Twickler, H.P.F.Koppeschaar, M.J.M. Cramer Expression of euthyroid sick syndrome in
postischaemic heart disease is related to increased cardiovascular mortality:new options for
intervention? Neth Heart J 2003 ,11,12, 497-500
Aleman. A, Bronk E., Kessels R., Koppeschaar H.P., van Honk J. A single administration of
testosterone improves visual-spatial ability in young women Psychoneuroendocrinology 2004; 29(5)
612-617
Peter Putman, Jack van Honk, Roy.P,C.Kessels, Martijn Mulder, Hans.P.F.Koppeschaar.
Salivary cortisol and short and long-term memory for emotional faces in healthy young women.
Psychoneuroendocrinology 2004; 29, 953-960.
Hans PF Koppeschaar, P Sytze van Dam, Andre Aleman and Edward HF de Haan
Role of growth hormone and insulin-like growth factor I in cognitive function. In: Growth
Hormone in Adults, 10 Years of KIMS, eds R. Abs and U. Feldt-Rasmussen, 2004, Oxford
PharmaGenesis Ltd, 179- 188.
Jack Van Honk, Dennis J.L.G. Schutter, Erno J.Hermans, Peter Putman, Adriaan Tuiten, Hans
P.F. Koppeschaar. Testosterone shifts the balance between sensitivity for punishment and reward in
healthy young women Psychoneuroendocrinology 2004; 29, 937-943.
Curriculum Vitae – Hans Koppeschaar
20
Hans P.F. Koppeschaar, Vera Popovic, Alfonso Leal, Xose Otero, Elena Torres, Concha Paramo,
Dragan Micic, Ricardo V Garcia-Major, Carlos Dieguez, Felipe F Casanueva. Growth Hormone (GH)
peaks versus Areas Under the Curve in the diagnosis of Adult GH Deficiency: Analysis of the variables
provided by the GHRH+GHRP-6 test. Pituitary 2004, 7 (1): 15-20.
Th.B. Twickler, M.J.M. Cramer, S.P. Senden, P.A.Doevendans, W.R. de Vries, D.W. Erkelens, H.P.F.
Koppeschaar. Acromegaly and Heart Failure: Revisions of the Growth Hormone / Insulin-Like Growth
Factor Axis and its Relation to the Cardiovascular System Seminars in Vascular Medicine 2004;4:115120
W.R.Creyghton, P.Sytze van Dam, H.P.F.Koppeschaar The role of the Somatotropic System in
Cognition and other Cerebral Functions Seminars in Vascular Medicine 2004;4:167-172.
W.R. de Vries, M. Lamberts, D.P. van Zanten, M.O. Osman-Dualeh, I.Maitimu, and H.P.F.
Koppeschaar . Age-Related Differences In Growth Hormone (GH) Regulation During Strenuous
Exercise Hormone and Metabolic Research 2004;36:501-505.
D.J.L.G. Schutter., J.Van Honk., E.H.F. De Haan., A.C. Van Huffelen., P.S. Van Dam., W.R. De Vries.,
H.P.F.Koppeschaar. Cortisol, depression and cortico-cortical cross-talk in Cushing’s syndrome.
Journal of Endocrinological Investigation 2004, 27 (7) 683-68
A. Postma, G. Jager, R.P.C. Kessels, H.P.F. Koppeschaar, J.van Honk. Sex differences
for selective forms of spatial memory. Brain Cogn. 2004, 54 (1): 24-34.
P.M.J. Zelissen,K. Stenlof, M.E.J. Lean, J. Fogteloo, E.T.P. Keulen, J. Wilding, N.Finer, S. Rossner, E.
Lawrence, C. Fletcher and M.McCamish on behalf of the author group T.W.A. De Bruin,
H.P.F.Koppeschaar, L. Sjostrom, G. Williams Effect of three treatment schedules of recombinant
methionyl human leptin on body weight in obese subjects: a randomized, placebo-controlled trial.
Diabetes, Obesity and Metabolism (2005) 7 (6): 755-761
S.V.Haijma, P.S.van Dam, W.R.de Vries, I Maitimu-Smeele, C.Diequez, F.F.Casanueva,
H.P.F. Koppeschaar. The GHRH/GHRP-6 test for the diagnosis of growth hormone deficiency in
elderly and severely obese men. 2005, Eur J Endocrinol, vol 152, 4, 575-580.
Kevin C.J. Yuen, Jan Frystyk, Deborah K. White, Tb.B.Twickler, Hans.P.F.Koppeschaar, Philip
E.Harris, Linda Fryklund, Peter R. Murgatroyd and David B. Dunger Paradoxical Enhancement of
Insulin Sensitivity Without Concomitant Changes in Body Composition in GH Deficient Adults
Following 12-Month Fixed Low Dose GH Administration. Clin Endocrinol (Oxf) 2005 Oct; 63(4): 428436.
P.S van Dam, M.Lijffijt, A.Aleman, C.F. de Winter , R. de Vries , J. van de Grond , H.P.F.Koppeschaar
Childhood-onset growth hormone deficiency, cognitive function and brain n-acetylaspartate
Psychoneuroendocrinology 2005,30 (4), 357-362.
F.Kelestimur, V. Popovic, A. Leal, P.S . van Dam, E.Torres, L.F.Perez Mendez, Y.Greenman
H.P.F.Koppeschaar, C.Diequez, F.F.Casanueva Effect of obesity and morbid obesity on the growth
hormone(GH) secretion elicited by the combined GHRH+GHRP-6 test Clin Endocrinol 2006 64 (6)
667-671.
A.M. Pereira, A.A. van der Klauw, H.P.F.Koppeschaar, S.W. van Thiel, J. van Doorn, N.R. Biermasz
F. Roelfsema, and J.A. Romijn. Efficacy of needle free administration of recombinant human growth
hormone in adults with growth hormone deficiency Br J Clin Pharmacol 2006, 61(4):451-455
D.J.L.G.Schutter,J., J.S.Peper, H.P.F.Koppeschaar, R.S.Kahn & J van Honk Administration
of testosterone Increases functional connectivity in a cortico-cortical depression circuit.
J Neuropsychiatry Clin Neurosci 2005, 17(3), 372-377.
Curriculum Vitae – Hans Koppeschaar
21
L.F. van Gaal, A.M. Rissanen, A.J. Scheen, O.Ziegler, S.Rossner and for the RIO-Europe StudyGroup
(H.P.F. Koppeschaar et al,) Effects of the cannaboid-1 receptor blocker rimonabant on
weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the
RIO-Europe study. The Lancet, 2005, 365,9468, 1389-1397.
Jan M van Ree, Jules H. Schagen van Leeuwen, Hans P.F. Koppeschaar, Egbert R te Velde
Unexpected placebo response in premenstruel dysphoric disorder: implication of endogenous opioids
Psychopharmacology ( 2005) 182: 318-319.
Erno J. Hermans, Peter Putman, Johanna M. Baas, Hans P.F. Koppeschaar, Jack van Honk
A Single Administration of Testosterone Reduces Fear- Potentiated Startle in Humans
Biol Psychiatry 2006,1;59 (9) 872-874.
C.J.M. Lips, H.P.F.Koppeschaar, P.M.J. Zelissen, P.S. Van Dam, J.M.H. de Klerk, B.A. Zonnenberg,
Tumoren van endocriene klieren,in Oncologie, C.J.H. van de Velde, et al Editors. 2005, zevende
herziene druk, Bohn Stafleu van Loghum p. 411-440.
M. Koltowska-Haggstrom, A.F.Mattsson, J.P.Monson, P.Kind, X.Badia, F.F.Casanueva,
J.Busschbach, H.P.F.Koppeschaar, G.Johannsson Does long-term growth hormone replacement
therapy in adults with growht-hormone deficiency normalise quality of life? Eur J Endocrinology (2006)
155 109-119
B.Saller, A.F.Mattsson, P.H.Kann, H.P.Koppeschaar, J.Svensson, M.Pompen, M.KoltowskaHaggstrom
Healthcare utilization, quality of life and patient-reported outcomes during two years of growth
hormone (GH) replacement therapy in GH-deficient adults – comparison between Sweden, The
Netherlands and Germany European Journal of Endocrinology (2006) 154; 843-850.
The Dream (Diabetes Reduction Assessment with ramipril and rosiglitazone medication)
Trial Investigators * ( a.o., H.P.F.Koppeschaar) Effect of rosiglitazone on the frequency of diabetes in
patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial
The Lancet (2006), 9541, 1096-1105.
Peter Putman, Erno Hermans, Hans. P. F. Koppeschaar, Alexandra van Schijndel, Jack van Honk
A single administration of cortisol acutely reduces pre-conscious attention for fear in anxious young
men Psychoneuroendocrinology (2007) 32, 793-802
Hunault C.C., Lambers A.C., Mensinga T.T., van Isselt J.W., Koppeschaar H.P.F., Meulenbelt J.
Effects of sub-chronic nitrate exposure on the thyroidal function in humans Toxicology letters 2007
dec 10, 175 (1-3): 64-70
Johan Svensson, Nick Finer, Pierre Bouloux, John Bevan, Bjorn Jonsson, Anders F Mattsson, Mikael
Lundberg, Philip E Harris, Maria Koltowska-Haggstrom, John P Monson, on behalf of the KIMS
International Board (a.o H.P.F.Koppeschaar) Growth Hormone (GH) replacement therapy in GH
deficient adults: Predictors of one-year metabolic and clinical response Growth Hormone & IGF
Research 2007 17, 67-76
Hans.P.F.Koppeschaar. Adult Clinical Session. Introduction. Endocrine incidentaloma Horm Res
2007; 68 suppl 5:189-190
H.P.F.Koppeschaar, E.H. Quik Sleep and Quality of Life in Endocrine Diseases
In Sleep and Quality of Life in Clinical Medicine Humana Press Inc, Eds J.Verster, S.R. PandiPerumal, D.L. Streiner .
2008;47; 453-461.
Rob J. van Geest, Inna V. Sasim, Hans P.F. Koppeschaar, Rachel Kalmann, Simone Stravers,
Ward Bijlsma and Maarten P. Mourits Methylprednisolone pulse therapy for patients with moderately
severe Graves’ Orbitopathy: a prospective, randomized, placebo-controlled study Eur J Endocrinol
2008 feb; 158(2): 229-237.
Curriculum Vitae – Hans Koppeschaar
22
Pauline Smit, Hans.P.F.Koppeschaar Growth Hormone Therapy and Risk of Malignancy
The Endocrinologist 2008; 18 (1) : 39-43
Dream Trial Investigators * ( a.o., Koppeschaar H. P.F. ) Effect of Ramipril and Rosiglitazone on
cardiovascular and renal outcomes in people with impaired glucose tolerance or impaired fasting
glucose: results of the Diabetes Reduction Assessment with ramipril and rosiglitazone Medication
(Dream) trial Diabetes Care, 2008 May; 31(5):1007-14
Van Gaal L.F., Scheen A.J., Rissanen A.M., Rossner S., Hanotin C., Ziegler O., RIO-Europe Study
Group (o.a., H.P.F.Koppeschaar) Long-term effect of CB1 blockade with Rimonabant on
cardiometabolic risk factors: two years results from the RIO-Europe Study Eur Hart J. 2008 jul; 29(14):
1761-1771
S.W.Genders, H.P.F.Koppeschaar, R.Kalmann Auto-immuun schildklierziekte, de rol van antistoffen
Graves Bulletin, (voorjaar 2008) Artsenbrochure Graves Bulletin herfst 2009, 16-19
C.R.C.Pieterman, J.M.J. Schreinemakers, H.P.F.Koppeschaar, M.R.Vriens, I.H.M. Borel Rinkes, B.A.
Zonneberg, R.B. van der Luijt, G.D. Valk Multiple endocrine neoplasia type 1 ( MEN1): clinical aspects
and effect of genetic screening Clin Endocrinol (Oxf). 2009 Apr, 70(4): 575-581
Van der Made F, Bloemers J, Yassem WE, Kleiverda G, Everaerd W, van Ham D, Olivier B,
Koppeschaar H, Tuiten A J. The influence of testosterone combined with a PDE5-inhibitor on
cognitive, affective, and physiological sexual functioning in women suffering from sexual disfuction
J Sex Med 2009 Mar: 6(3) 777-90
Sandor Schmikli, Peter Vergouwen, Wouter de Vries, Frank Backx, Hans Koppeschaar Prediction of
subjectively rated performance capacity in elite male endurance-, interval- and resistance exercise
athletes Medicina Sportiva 2009, 13(3), 155-162
Legros JJ, Meuleman EJ, Elbers JM, Geurts TB, Kaspers MJ, Bouloux PM for the Study 43203
Investigators (H.P.F.Koppeschaar)
Oral testosterone replacement in symptomatic late-onset hypogonadism: effects on rating scales and
general safety in a randomized, placebo-controlled study Eur J Endocrinol (2009) 160 821-831
Bloemers J, Gerritsen J, Bults R, Koppeschaar H, Everaerd W, Olivier B, Tuiten A
Induction of Sexual Arousal in Women Under Conditions of Institutional and Laboratory
Circumstances: A Comparative Study J Sex Med 2010 7(3) 1160-76
I.C. van Nieuwpoort, C.C. van Bunderen, L.I. Arwert, A.A.M.Franken, H.P.F.Koppeschaar, A.J. van
der Lelij J.W.R. Twisk, M.Boers, M.L.Drent Dutch National Registry of Growth Hormone Treatment
in Adults: patient characteristics and diagnostic test procedures Eur J Endocrinol (2011) 164 (4) : 491497
van Bunderen CC, van Nieuwpoort IC, Arwert LI, Heymans MW, Franken AA, Koppeschaar HP, van
der Lely AJ, Drent ML Does Growth Hormone Replacement Therapy Reduce Mortality in Adults with
Growth Hormone Deficiency? Data from the Dutch National Registry of Growth Hormone Treatment in
Adults. J Clin Endocrinol Metab, 2011, Oct, 96 (10): 3151-9 (Epub 2011 Aug 17)
Kim van Rooij, Jos Bloemers, Leo de Leede, Irwin Goldstein, Eef Lentjes, Hans Koppeschaar, Berend
Olivier, Adriaan Tuiten Pharmacokinetics of three doses of sublingual testosterone in healthy
premenopausal women Psychoneuroendocrinology (2011) Oct 5, (Epub ahead of print)
Christa C. van Bunderen, I.Caroline van Nieuwpoort, Lucia I. Arwert, Martijn W.Heymans, Anton A.M.
Franken, Hans.P.F.Koppeschaar, Aart J. van der Lelij en Madeleine L. Drent Effect van
groeihormoonbehandeling op sterfte bij volwassenen met ernstige groeihormoondeficientie
Ned Tijdschr Geneeskd 2012;156:A4288,1-8.
E.H.Quick, G.D.Valk, M.L.Drent, L.J.A..Stalpers, J.L.Kenemans, H.P.F.Koppeschaar, P.S. van Dam
Reduced Growth Hormone secretion after cranial irradiation contributes to neurocognitive dysfunction
Growth Horm IGF Res, 2012,Feb;22(1): 42-7 (Epub 2012, Jan 21)
Curriculum Vitae – Hans Koppeschaar
23
Quik E.H, Conemans E B, Valk G.D, Kenemans J.L, Koppeschaar H.P, Dam P.S Cognitive
performance in older men is associated with growth hormone secretion Neurobiol aging 2012, 33, 3,
582-587
J.Bloemers, K. van Rooij, S.Poels, I.Goldstein, W.Everaerd, H.Koppeschaar, M.Chivers, J.Gerritsen,
D. van Ham, B.Olivier, A.Tuiten Toward Personalized Sexual Medicine (Part 1): Integrating the “Dual
Control Model” into Differential Drug Treatments for HSDD and FSAD in press J Sex Med 2012 Nov 6
(Epub ahead of print) PMD: 23130782
Poels S., Bloemers J., van Rooij K., Goldstein I., Gerritsen J., van Ham., van Mameren F., Chivers M.,
Everaerd W., Koppeschaar H., Olivier B., Tuiten A. Toward Personalized Sexual Medicine (Part 2):
Testosterone combined with a PDE5 inhibitor increases sexual satisfaction in women with HSDD and
FSAD, and a low sensitive system for sexual cues in press J Sex Med 2012 Nov 6 (Epub ahead of
print) PMD: 23130748
Kim van Rooij, Saskia Poels, Jos Bloemers, Irwin Goldstein, Jeroen Gerritsen, Diana van Ham,
Frederiek van Mameren, Meredith Chivers, Walter Everaerd, Hans Koppeschaar, Berend Olivier,
Adriaan Tuiten Toward Personalized Sexual Medicine (Part 3): Testosterone combined with a
serotonin 1a receptor agonist increases sexual satisfaction in women with HSDD ans FSAD, and
dysfunctional activation of sexual inhibitory mechanisms in press J Sex Med 2012 Nov 6 (Epub ahead
of print) PMD:23130675
Pierre M.G.Bouloux, Jean-Jacques Legros, Jolande M.H. Elbers, T.B.Paul Geurts, Marion J.G.H.
Kaspers, Alan G Meehan, Eric J.H.Meuleman, and for the study 43203 Investigators ( a.o.
H.P.F.Koppeschaar) Effects of oral testosterone undecanoate therapy on bone mineral density and
body composition in 322 aging men with symptomatic testosterone deficiency: a 1-year, randomized,
placebo-controlled, dose-ranging study Aging Male 2013;16(2):38-47
J.Gerritsen, D.M.M. van Ham, J.M.M.Bloemers, K.B.E.Bocker, H.P.F.Koppeschaar, W.T.A.M.
Everaerd, B.Olivier, J.J.A.Tuiten Testosterone, combined with sildenafil, modulates startle responses
and facial EMG evoked during erotic pictures in sexually dysfunctional women with high sensitivity for
sexual cues (submitted, Archives of Sexual Behavior)
Kim van Rooij, Leo de Leede, Jos Bloemers, Saskia Poels, Hans Koppeschaar, Berend Olivier and
Adriaan Tuiten Pharmacokinetics of a prototype formulation of sublingual testosterone and a
buspirone tablet, versus an advanced combination tablet of testosterone and buspirone in healthy
premenopausal women (2014 Drugs in R&D)
Christa C. van Bunderen, Carline J. van den Dries, Martijn W. Heymans, Anton A.M. Franken,
Hans.P.F.Koppeschaar, Aart J. van der Lely, Madeleine L.Drent The Effect of Long-Term Growth
Hormone Replacement Therapy on Cardiovascular Outcomes in Isolated Growth Hormone Deficiency
compared to Multple Pituitary Hormone Deficiencies. A Sub-Analysis from the Dutch National Registry
of Growth Hormone Treatment in Adults ( 2014, May 6, Eur J Endocrinology)( Epub ahead of print)
Saskia Poels, Jos Bloemers, Kim van Rooij, Hans Koppeschaar, Berend Olivier, Adriaan Tuiten Two
novel combined drug treatments for women with Hypoactive Sexual Desire Disorder ( Pharmacol
Biochem Behav, 2014 Feb 15 ( Epub ahead of print))
Saskia Poels, Jos Bloemers, Kim van Rooij, Hans Koppeschaar, Berend Olivier en Adriaan Tuiten Een
vernieuwende farmacotherapeutische behandeling voor vrouwen met Hypoactive Sexual Desire
Disorder (submitted, Neuropraxis)
Christa C. van Bunderen, Nadege C. van Varsseveld, Martijn W. Heymans, Anton A.M. Franken, Hans
P.F.Koppeschaar, Aart J. van der Lely, Madeleine L.Drent The Effect of Long-Term Growth Hormone
Replacement Therapy on Cardiovascular Outcomes in Growth Hormone Deficiency after Previous
Acromegaly – A Sub-Analysis from the Dutch National Registry of Growth Hormone Treatment in
Adults (submitted April 2014)
Curriculum Vitae – Hans Koppeschaar
24
ABSTRACTS / POSTERS / LECTURES for Learned Audiences
A.E. Meinders, H.P.F. Koppeschaar, P. Oldenbroek, V. Cejka. The effect of rehydration alone in the
treatment of insulin dependent diabetes mellitus with ketoacidotic coma or precoma
Acta Endocr (Kbh) 1977; suppl 211, 442
H.P.F. Koppeschaar, A.E. Meinders, B.R. v. Neerbos
The effect of modified starvation alone and in combination with exogenous induced T3 thyrotoxicosis
on body weight and thyroid hormone metabolism
J Endocrinol 1979; 80: 21.
H.P.F. Koppeschaar, A.E. Meinders, F.D.A. Sindram, B.R. v. Neerbos
Relationship between the urinary concentrating ability of the kidney and thyroid function during
modified starvation
J Endocrinol 1979; 80: 23.
H.P.F. Koppeschaar, A.E. Meinders, E.D.A. Sindram
Metabolic effects of partial starvation alone and in combination with T3 (Liothyronine) in grossly obese
subjects
Acta Endocr (Kbh) 1979; 321: 225.
H.P.F. Koppeschaar
Metabool en hormonaal onderzoek tijdens hongeren
Neth J Med 1980;
H.P.F. Koppeschaar, A.E. Meinders, F. Schwarz
Metabolic events during caloric restriction and T3 therapy
Int J Obesity 1982; Proceedings Int Conference; The Adipocyte and Obesity: Cellular and Molecular
Mechanisms, Toronto.
F. Teding van Berkhout, R.J.M. Croughs, H.P.F. Koppeschaar, J.H.H. Thijssen, F. Schwarz, C.
Kooyman
Twee zusjes met het syndroom van Cushing
Ned Tijdschr Geneeskd 1984; 128: 336-7.
H.P.F. Koppeschaar, R.J.M. Croughs, J.H.H. Thijssen, F. Schwarz
Neurotransmitter modulating drugs in Cushing's disease
J Endocrinol Invest 1985; 8: 183.
Hill P, F. de Waard, J.H.H. Thijssen,L. Garbackzewski, H.P.F. Koppeschaar, V. Ramshorst
Gut-CNS-Peptide hormones in healthy women and breast cancer patients
Proceedings, Third Annual ECP Symposium, Diet and Human Carcinogenesis, Aarhus, Denmark,
1985: 53.
Curriculum Vitae – Hans Koppeschaar
25
P. Hill, L. Garbackzewski, J.H.H. Thijssen,H.P.F. Koppeschaar
Gut-CNS-Peptide hormone response to meals in non-obese, obese women
Proceedings, 67th Annual Meeting, The Endocrine Society, Baltimore, Maryland, 1985: 659.
J. Koningsberger, H.P.F. Koppeschaar, J.H.H. Thijssen, D.W. Erkelens
Treatment of hypoglycemia due to insulinoma with somatostatin analoque SMS 201-995
International Symposium on Somatostatin: Recent advances in basic research and clinical application,
Madrid, 1986.
H.P.F. Koppeschaar, M. Page, T. Donker, J.H.H. Thijssen, C. Dieguez, M.F. Scanlon
The effect of chronic SMS 201-995 treatment on the concentration of different forms of hGH
International Symposium on Somatostatin: Recent advances in basic research and clinical application,
Madrid, 1986.
H.P.F. Koppeschaar, P. Hill, L. Garbackzewski, J.H.H. Thijssen
Effect of meals and Naloxone administration on peptide hormones in lean and obese women
5th International Congress on Obesity, Jerusalem, Israel, 1986: 60.
M.D. Page, C. Dieguez, C.A. Edwards, H.P.F. Koppeschaar, M.F. Scanlon
Additive effects of GRH and Insulin on GH release in man
74th Meeting of the British Society for Endocrinology, 1986.
H.F.A. Vasen, H.P.F. Koppeschaar, C.B.H.W. Lamers, C.J.M. Lips
The multiple Endocrine Neoplasia Syndrome type I: the value of periodic screening: a study of 11
kindreds in the Netherlands
First European Congress of Endocrinology, Copenhagen, Denmark, 1987.
P. Hill, L. Garbackzewski, J.H.H. Thijssen, F. de Waard, H.P.F. Koppeschaar
Fat, Gut-CNS Peptide hormones and breast cancer
Proceedings, 78th Annual Meeting, American Association for Cancer Research, 1987.
H.P.F. Koppeschaar
Voeding, lichaamsgewicht en regulatie van de schildklier
Boerhaave cursus 1987: 95-100.
C.D. ten Horn, H.P.F. Koppeschaar, F.A. Opmeer
Concentrations plasmatiques en somatomedine-C (Sm-C) et en hormone somatrotrophe (GH) chez
les malades souffrant d'une hypothyreoidie, avant et sous traitement par thyroxine
Annales d'endocrinologie 1988; 6: 33.
H.P.F. Koppeschaar, P.Hill, L.Garbaczewski, J.H.H. Thijssen
Effect of meals, Naloxone and Cholecystokinin on plasma neurotensin levels in lean and obese
women
Proceedings, 1st European Congress on Obesity, Stockholm, 1988: 229.
H. Pijl, H.P.F. Koppeschaar, A.E. Meinders, F. Willekens, H. Veldhuis
Influence of the serotonin re-uptake inhibitor Fluoxetine on Prolactin (PRL)/ Thyrotropin (TSH)
regulation in grossly obese females
Proceedings, 1st European Congress on Obesity, Stockholm, 1988: 234.
P.M.J. Zelissen, H.P.F. Koppeschaar, C.J.M. Lips, W.H.L. Hackeng Calcitonin and Calcitonin GeneRelated Peptide in obesity. First European Congress on Obesity, Stockholm, 5-6 Juni 1988.
Proceedings 230.
P.M.J. Zelissen, H.P.F. Koppeschaar
Release of TSH and Prolactin in obese women and men.
2nd European Congress on Obesity, Oxford, 29 Maart - 2 April 1989.
Int J Obesity 1989; 13, suppl 1: 64.
Curriculum Vitae – Hans Koppeschaar
26
P.M.J. Zelissen, H.P.F. Koppeschaar
Growth Hormone release and Somatomedin-C in obese patients with non insulin dependent diabetes
mellitus.
2nd European Congress on Obesity, Oxford, 29 Maart - 2 April 1989.
Int J Obesity 1989; 13, suppl 1: 226.
H.P.F. Koppeschaar, B. Garcia, P.M.J. Zelissen, H.Westenberg, A.E. Meinders, H. Pijl
Platelet serotonin uptake in obesity.
2nd European Congress on Obesity, Oxford, 29 Maart - 2 April 1989.
Int J Obesity 1989; 13, suppl 1: 139.
H.P.F. Koppeschaar, P.M.J. Zelissen
Neuroendocrine regulation of hunger and satiety.
30ste Federa Bijeenkomst. Maastricht, 29 Maart 1989.
Proceedings 224.
P.M.J. Zelissen, H.P.F. Koppeschaar, F. Opmeer
Growth Hormone (GH) responsiveness to GH-releasing hormone (GHRH) in obese patients with noninsulin dependent diabetes mellitus (NIDDM); influence of weight reduction and of chronic treatment
with the serotoninergic drug Fluoxetine.
IVth Meeting of the European Neuroendocrine Association, Santiago de Compostela, 28-30 Juni 1989.
J Endocrinol Invest 1989; 12, suppl 2, 106.
P.M.J. Zelissen, H.P.F. Koppeschaar, C.J.M. Lips, W.H.L. Hackeng
Increased plasma concentration of Calcitonin Gene-Related Peptide in obesity: a primary
phenomenon?
1989 Annual Meeting of the North American Association for the study of Obesity, Bethesda, 13-16
September 1989.
Proceedings 84.
H.P.F. Koppeschaar, B. Garcia, P.M.J. Zelissen, H.Westenberg, A.E. Meinders, H. Pijl
Is platelet serotonin uptake a valuable tool for the prediction of successful treatment with serotonin
agonist drugs in obesity?
1989 Annual Meeting of the North American Association for the study of Obesity, Bethesda, 13-16
September 1989.
Proceedings 59.
C. Dieguez, M.D. Page, R. Valcavi, H.P.F. Koppeschaar, M.F. Scanlon
Plasma GHRH 1-44 and 1-40 levels in normal subjects following meals and during GH stimulation
tests
Proceedings, 8th Joint Meeting of British Endocrine Societies, Manchester, 1989.
W.R. de Vries, C. Vervoorn, H.P.F. Koppeschaar, F. van der Meer, A. ter Balkt, W.B.M. Erich, J.H.H.
Thijssen and H.A. Keizer: TRH- and exercise induced PRL responsiveness in men. FIMS World
Congress of Sports Medicine: 33, May 1990.
I.A. Huisveld, A. van Liempd, C. Vervoorn, J.E.H. Hospers, W.R. de Vries, H.P.F. Koppeschaar and
B.N. Bouma: Effect of intensive physical training on tPA and PAI-1. Proceedings PAI-Fibrinolysis
Workshop 3: 29, 1990.
L.B. Creemers, P.M.J. Zelissen, J.W. van 't Verlaat, H.P.F. Koppeschaar
Prolactinoma and body weight; a retrospective study.
2nd European Congress of Endocrinology, Ljubljana, 1-6 Juli 1990.
J Endocrinol Invest 1990; 13, suppl 2: 133.
R.Leenen, Kooy, P.Deurenberg, J.C. Seidell, H.P.F.Koppeschaar Body fat distribution and sex
hormone in relation to serum lipids in obese subjects J Steroid Biochem 1990, 36, suppl: 10 S
Curriculum Vitae – Hans Koppeschaar
27
P.M.J. Zelissen, H.P.F. Koppeschaar, H. Pijl, J.H.H. Thijssen
Response of cortisol and Beta-Endorphin to corticotrophin-releasing hormone in morbid obesity.
8th International Congress on hormonal steroids, Den Haag, 16-21 September 1990.
J Steroid Biochem 1990; 36, suppl: 58 S
P.M.J. Zelissen, H.P.F. Koppeschaar, J.H.H. Thijssen, D.W. Erkelens
Beta-Endorphin response to different meals in morbid obesity.
6th International Congress on Obesity, Kobe (Japan), 21-26 Oktober 1990.
Int J Obesity 1990; 14, suppl 2: 94.
P.M.J. Zelissen, H.P.F. Koppeschaar, H. Pijl, J.H.H. Thijssen
Adrenocortical function and beta-Endorphin response to corticotrophin-releasing hormone in morbid
obesity.
6th International Congress on Obesity, Kobe (Japan), 21-26 Oktober 1990.
Int J Obesity 1990; 14, suppl 2:94.
H. Pijl, H.P.F. Koppeschaar, A.E. Meinders, P.M.J. Zelissen, F.L.A. Willekens, H.D. Veldhuis
The influence of Fluoxetine on the pituitary-adrenal response in obesity.
6th International Congress on Obesity, Kobe (Japan), 21-26 Oktober 1990.
Int J Obesity 1990; 14, suppl 2: 93.
B. Guy-Grand, M. Apfelbaum, G. Crepaldi, A. Gries, P. Lefèbvre, P. Turner en de leden van de the
INDEX study groep (P.M.J. Zelissen, H.P.F. Koppeschaar, etc.)
Effect of withdrawal of dexfenfluramine on body weight and food intake after a one year's
administration.
6th International Congress on Obesity, Kobe (Japan), 21-26 Oktober 1990.
Int J Obesity 1990; 14, suppl 2: 48.
C. Vervoorn, W.R. de Vries, H.P.F. Koppeschaar, H.A. Keizer and W.B.M. Erich: De ontwikkeling van
geavanceerde testmethoden tot vaststelling van dreigende overtraining bij topsporters/sters. CocaCola Stipendium voor Sportgeneeskunde 1990, November, 1990.
P.M.J. Zelissen, H.P.F. Koppeschaar
Disparity between dynamic tests and efficacy of chronic treatment in a patient with non-neoplastic
inappropriate secretion of TSH (nnIST).
5th European workshop on pituitary adenomas, Venetië, 17-20 Maart 1991.
J Endocrinol Invest 1991; 14, suppl 1: 80.
H.P.F. Koppeschaar, M.B. Garcia, J.H.H. Thijssen, M.J. Hendriks
Response to continuous infusion of octreotide (CSI) in patients with active acromegaly
J. Endocrinol. Invest 1991, 14: 115
C. Vervoorn, H.P.F. Koppeschaar and W.R.de Vries: De rol van het endocriene systeem bij krachtsnelheidssporten. Abstract Sports Medicare International Congress, Rotterdam, 1991.
W.R. de Vries, P. Platen, C. Vervoorn, H.A. Keizer, H.P.F. Koppeschaar, W.B.M. Erich and J.H.H.
Thijssen: Basal plasma Beta-Endorphin as a function of acute exercise and training. Medicine and
Science in Sports and Exercise 23: 4, suppl. 646, 1991.
C. Vervoorn, H.A. Keizer, H.P.F. Koppeschaar, P. Platen, W.B.M. Erich, J.H.H. Thijssen and W.R. de
Vries: Changes in plasma Beta-Endorphin and PRL after a short term intensive training program.
Medicine and Science in Sports and Exercise 23: 4, suppl. 648, 1991.
H.A. Keizer, P. Platen, H.P.F. Koppeschaar, W.R. de Vries, C. Vervoorn, P. Geurten and G. van
Kranenburg: Decreased Beta-Endorphin responses to exercise after exhaustive training. Medicine and
Science in Sports and Exercise 23: 4, suppl.647, 1991.
Curriculum Vitae – Hans Koppeschaar
28
K.P. Bouter, R.J.A. Diepersloot, M.J.W. Sprenger, J. Krabbe, M.H. Helsloot, hpfk, J.B.L. Hoekstra,
D.W. Erkelens, N. Masurel
Humoral immune response to trivalent influenza vaccine in patients with Graves' diseaseNeth J Med
1991; 6: A49.
Roelen, C.A.M., G.H. Donker, J.H.H. Thijssen, H.P.F. Koppeschaar, M.A. Blankenstein
Plasma growth hormone binding protein (GHBP) in acromegaly: measurement and effect of octreotide
treatment
Abstracts 9th. International Congress of Endocrinology. Nice, France 1992: 313.
Meinders, A.E., H. Pijl, H.P.F. Koppeschaar
Serotoninergic medication and pituitary hormone release in obesity
Abstracts 9th. International Congress of Endocrinology. Nice, France 1992: 574.
Koppeschaar, H.P.F., C.J.M. Lips, J.M. Jansen-Schillhorn, Th.J.M.V. van Vroonhoven
Clinical and biochemical observations in a family with the MEN-1 syndrome
Abstracts 9th. International Congress of Endocrinology. Nice, France 1992: 598.
Lips, C.J.M., H.P.F. Koppeschaar, W.H.L. Hackeng, R.A. Geerdink, J. Jansen-Schillhorn, Th.J.M.V.
van Vroonhoven, A. Struivenberg
Long-term follow-up in four large MEN-II families in The Netherlands
Abstracts 9th. International Congress of Endocrinology. Nice, France 1992: 599.
Pijl, H., H.P.F. Koppeschaar, A.E. Meinders
Serotonin and pituitary hormone release in obesity
Int J Obesity 1992; 16: P214.
Pijl, H., A.F. Cohen, H.P.F. Koppeschaar, J.A. Iestra, A.E. Meinders
Serotonin mediated control of carbohydrate intake
Int J Obesity 1992; 16: P215.
Visser, M., J. Seidell, H.P.F. Koppeschaar, P. Smits
The effect of fluoxetine on body weight and abdominal fat areas assessed by magnetic resonance
imaging
Int J Obesity 1992; 16: P271.
Zonneveld, P. van, H.P.F. Koppeschaar, E.R. te Velde
Ovarian disorders detected by extended cycle analysis
Abstracts of the 8th Annual Meeting of the European Society of Human Reproductive Endocrinology,
Den Haag 1992: 47.
Koppeschaar, H.P.F., P. van Zonneveld, E.R. te Velde, Th.J.M.V. van Vroonhoven
A patient with an adrenal adenoma presenting with primary amenorrhea
Abstracts of the 8th Annual Meeting of the European Society of Human Reproductive Endocrinology,
Den Haag 1992: 46.
H.P.F. Koppeschaar, C.J.M. Lips
Clinical and biochemical observations in a family with the MEN-I syndrome
Abstracts 9th. International Congress of Endocrinology. Nice, France 1992: 19.04.072.
Graeff, A. de, C.J.M. Lips, M.S. Leeuwen, Th.M.J.V. van Vroonhoven, H.P.F. Koppeschaar
Preoperative localization of insulinomas.
Abstracts 9th. International Congress of Endocrinology. Nice, France 1992: 592.
Tuiten, A., H.P.F. Koppeschaar, G. Panhuysen, W. Everaerd, E.R. te Velde, M. Smeets, E. Laan
Mental stress and menstrual cycle related changes of the tryptophan ratio influence mood and
appetite
Neuroendocrinol Letters 1992; 14: 259.
Curriculum Vitae – Hans Koppeschaar
29
C. Nieuwenhoff, H. Koppeschaar, P. Verstappen, C. Vervoorn, H. Keizer, W. de Vries
Seasonal changes in basal plasma levels of hormones and binding proteins in professional cyclists
Pflugers Archiv 1992; 5: R41,22.
Smeets, M., G. Panhuysen, A. Tuiten, W. Everaerd, H.P.F. Koppeschaar
A meta-analysis on body size estimation experiments in anorexia nervosa
Neuroendocrinol Letters 1992; 14: 310.
Tuiten, A., G. Panhuyzen, W. Everaerd, E. Laan, H.P.F. Koppeschaar, E.R. te Velde, M. Smeets
Anorexia nervosa and sexuality
Neuroendocrinology Letters 1992; 14: 259.
W.R. de Vries, H.P.F. Koppeschaar, P.A. Verstappen, E. Bol, H.A. Keizer, C.M. Nieuwenhoff and
J.H.H. Thijssen: Changes in basal plasma levels of testosterone and cortisol in professional cyclists.
Medicine and Science in Sports and Exercise 24, 5: S 166, 1992.
Brink, H.R. v.d., M.A. Blankenstein, H.P.F. Koppeschaar, J.W.J. Bijlsma
Influence of disease activity on steroid hormone levels in peripheral blood of patients with rheumatoid
arthritis
Br J Rheumatol 1992; 31: 28.
Hakman, M.E., J.N.C.M. Fouchier, F.A. Pameijer, H.P.F. Koppeschaar, J.M.H. Klerk, P.P. van Rijk
Volumemeting van euthyreotisch multinodulair struma bij therapie met Jodium-131
Abstracts Wetenschappelijke Vergadering Nederlandse Vereniging voor Nucleaire Geneeskunde,
Amsterdam 1992.
H.P.F. Koppeschaar, M.L. Drent, P.M.J. Zelissen, A.C. Nieuwenhuijzen Kruseman, J.A. Lutterman,
E.A. van der Veen
Effects of dexfenfluramine (DF) on the eating patterns of Dutch overweight android "snackers".
Symposium "The role of dexfenfluramine in the regulation of energy balance", Ulm, 10 juni 1993.
Int J Obesity 1993; 17, suppl 2: 109.
Leenen, R., K. van der Kooy, J.C. Seidell, P. Deurenberg, H.P.F. Koppeschaar
Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight
loss therapy
Int J Obesity 1993; 17: 57.
Vervoorn, C., W. de Vries, H. Keizer, H.P.F. Koppeschaar
The responses of prolactin (PRL) and Beta-endorphin (END) to releasing hormone challenge tests and
an exercise test
Med Science in Sports and Exercise 1993; 25: S187.
Roelen, C.A.M., G.H. Donker, H.P.F. Koppeschaar, J.H.H. Thijssen, M.A. Blankenstein
Plasma growth hormone binding protein (II-GHBP) in acromegaly: measurement and effect of
octreotide treatment
Neth J Med 1993; 5: A64.
Vasen, H.F.A., K.J. van Erpecum, F. Roelfsema, F. Raue, H.P.F. Koppeschaar, G. Griffioens, G.P.
Berge Henegouwen
Patients with acromegaly have an increased prevalence of colonic adenomas
Neth J Med 1993; 42: A3.
Pameyer, F.A., M.E. Hakman, J.H. van den Hout, J.P.J. van Schaik, J.H. Fouchier, H.P.F.
Koppeschaar, P.P. van Rijk, P.F.G.M. van Waes
Non-toxic goiter: CT measurement of thyroid volume
Eur Radiol 1993; 303: 1464.
Curriculum Vitae – Hans Koppeschaar
30
Pameyer, F.A., M.E. Hakman, J.P.J. van Schaik, H.P.F. Koppeschaar, P.P. van Rijk, P.F.G.M. van
Waes
Volume measurement of non-toxic goiter: Reliability of planar scintigraphy using CT as a gold
standard
Eur Radiol 1993; 303: 1366.
Garcia-Garcia, M.B., M.P. Mourits, H.P.F. Koppeschaar, D. Wittebol-Post, H.J.M. van Rijn
Glycosaminoglycans and Graves' orbitopathy
Int Ophthalmol 1993; 17: 2.
Stolk, M.F.J., K.J. Erpecum, H.P.F. Koppeschaar, M.A. Akkermans, A.J.P.M. Smout, G.P. Berge
Henegouwen
The effects of long-term therapy with intermittent octreotide injections on gastrointestinal motility in
acromegaly
Neth J Med 1993; 43: A2.
Y.E.M. Snel, M.E. Doerga, P.M.J. Zelissen, W.R. de Vries, M.L. Zonderland, P. Boer, H.P.F.
Koppeschaar
Body composition and body fat distribution in Growth Hormone deficient adults.
6th Meeting of the European Neuroendocrine Association, Lissabon, 5-6 Oktober 1993.
J Endocrinol Invest 1993; 16, suppl. 1: 167.
Y.E.M. Snel, M.E. Doerga, P.M.J. Zelissen, M.L. Zonderland, E. Bol, W.R. de Vries, H.P.F.
Koppeschaar
Energy intake of Growth Hormone deficient adults.
Fourth International Meeting on Clinical Research om Growth Hormone deficiency in adults, Cannes,
19-20 November 1993.
Endocrinol Metab 1994; 1, suppl.A: 78.
Y.E.M. Snel, E. Bol, M.E. Doerga, P.M.J. Zelissen, M.L. Zonderland, W.R. de Vries, P. Boer, H.P.F.
Koppeschaar
Body composition and water content in Growth Hormone deficient adults.
Fourth International Meeting on Clinical Research om Growth Hormone deficiency in adults, Cannes,
19-20 November 1993.
Endocrinol Metab 1994; 1, suppl.A: 84.
Y.E.M. Snel, M.E. Doerga, M.L. Zonderland, P.M.J. Zelissen, E. Bol, W.R. de Vries, H.P.F.
Koppeschaar
Resting metabolic rate in Growth Hormone dificient adultsFourth International Meeting on Clinical
Research om Growth Hormone deficiency in adults, Cannes, 19-20 November 1993 Endocrinol Metab
1994; 1, suppl.A: 76.
M.E. Doerga, H.A. Keizer, P. Geurten, G. van Kranenburg, Y.E.M. Snel, P.M.J. Zelissen, W.R. de
Vries, H.P.F. Koppeschaar
Growth Hormone deficiency may induce a decrease in type I fibres of the vastus lateralis.
Fourth International Meeting on Clinical Research on Growth Hormone deficiency in adults, Cannes,
19-20 November 1993.
Endocrinol Metab 1994; 1, suppl.A: 77.
Y.E.M. Snel, E. Bol, M.E. Doerga, P.M.J. Zelissen, M.L. Zonderland, W.R. de Vries, P. Boer, H.P.F.
Koppeschaar
Body composition in Growth Hormone deficient adults assessed by four different techniques.
28th Annual Scientific Meeting of the European Society for Clinical Investigation, Toledo, 20-23 April
1994.
Eur J Clin Invest 1994; 24, suppl.2: A62.
Curriculum Vitae – Hans Koppeschaar
31
M.E. Hakman, F.A. Pameijer, J.M.H. de Klerk, H.P.F. Koppeschaar, P.M.J. Zelissen, J.W. van Isselt,
J.H.C.M. Fouchier, P.P. van Rijk
Volume reduction in non-toxic goiter after iodine-131 treatment, measured by thyroid scintigraphy and
CT.
41st Annual Meeting of the Society of Nuclear Medicine, Orlando, 5-8 juni 1994.
J Nucl Med 1994; 35: 163P-164P (Abstract 655).
M.E. Doerga, Y.E.M. Snel, P.M.J. Zelissen, P. Boer, H.P.F. Koppeschaar
Extracellular water, plasma renin activity, plasma aldosterone, atrial natriuretic peptide and 24 hour
+
Na excretion in growth hormone deficient adults
First International Meeting of the Growth Hormone Research Society, Aarhus, 1-4 juni 1994.
M.E. Doerga, Y.E.M. Snel, P.M.J. Zelissen, J.H.H. Thijssen, H.P.F. Koppeschaar
Insulin-like Growth Factor-1 (IGF-1), Glucose/Insulin ratio and IGF-binding proteins (IGF-BP 1 and 3)
in Growth Hormone (GH) deficient adults
Seventeenth International Symposium on Growth and Growth disorders, Barcelona, 15-16 april 1994.
Proceedings: pagina 62, abstract nr. 28.
Bernards, A.T.M., M.H. de Rooij, W.R. Vries, J.H.H. Thijssen, H. van Rijn, H.P.F. Koppeschaar
Changes in stress-related hormones during acute physical exercise
Neth J Med 1994; 44: A1.
Stolk, M.F.J., K.J. van Erpecum, H.P.F. Koppeschaar
Effects of long-term octreotide treatment on interdigestive gallbladder emptying antroduodenal motility
and motilin release in acromegaly
Neth J Med 1994; 44: A31.
Stolk, M.F.J., K.J. van Erpecum, H.P.F. Koppeschaar, A.J.P.M. Smout,
J.B.M.J. Jansen, C.B.H.W. Lamers, G.P. Berge Henegouwen
Effects of octreotide on gallbladder function, antroduodenal motility and gastrointestinal hormone
release in man
Neth J Med 1994; 44: A3.
Visser, M., J.C. Seidell, H.P.F. Koppeschaar
No specific effect of fluoxetine treatment on fasting glucose, insulin, lipid levels and blood pressure in
healthy men with abdominal obesity
Obesity Res 1994; 2: 152.
C.A.M. Roelen, M.E. Doerga, Y.E.M. Snel, P.M.J. Zelissen, J.H.H. Thijssen, M.A. Blankenstein, H.P.F.
Koppeschaar
Elevated Growth Hormone-Binding Protein levels in GH-deficient patients
Third European Congress of Endocrinology, Amsterdam, 17-22 juli 1994.
Eur J Endocrinol 1994; 130, suppl 2: 191.
J. Breed, W. Bronsveld, A. Kremer, H. Koppeschaar, P. Zelissen
Dexfenfluramine in obese hypertensive patients
Seventh International Congress on Obesity, Toronto, 20-25 augustus 1994.
Int J Obesity 1994; 18, suppl.2: 105.
Bernards, A.T.M., M.H. de Rooij, W.R. de Vries, J.H.H. Thijssen, H. van Rijn, H.P.F. Koppeschaar
Changes in stress-related hormones during acute physical exercise
Neth J Med 1994; 44: A1.
Stolk, M.F.J., K.J. van Erpecum, H.P.F. Koppeschaar
Effects of long-term octreotide treatment on interdigestive gallbladder emptying antroduodenal motility
and motilin release in acromegaly
Neth J Med 1994; 44: A 31.
Curriculum Vitae – Hans Koppeschaar
32
Stolk, M.F.J., K.J. van Erpecum, H.P.F. Koppeschaar, A.J.P.M. Smout, J.B.M.J. Jansen, C.B.H.W.
Lamers, G.P. van Berge Henegouwen
Effects of octreotide on gallbladder function, antroduodenal motility and gastrointestinal hormone
release in man
Neth J Med 1994; 44: A3.
M.E. Hakman, F.A. Pameijer, J.M.H. de Klerk, H.P.F. Koppeschaar, P.M.J. Zelissen, J.W. van Isselt,
J.H.C.M. Fouchier, P.P. van Rijk
Iodine-131 therapy in non-toxic goiter: volume reduction measured by CT
European Association of Nuclear Medicine Congress 1994, Düsseldorf, 20-24 augustus 1994.
Eur J Nucl Med 1994; 21: 810.
H. Keizer, M.E. Doerga, P. Geurten, G. van Kranenburg, Y.E.M. Snel, H.P.F. Koppeschaar
Growth hormone replacement may increase muscle enzyme activity in growth hormone deficient
patients
18th International Symposium on Growth Hormone and Growth factors in Endocrinology and
Metabolism, Gothenburg, 21-22 oktober 1994.
Endocrinol Metab 1995; 2 (suppl B), 141.
P. van Zonneveld, E.R. te Velde, H.P.F. Koppeschaar, J.D.F. Habbema, M.J. Eimers, C. de Brouwer,
R. van Ommen
Diagnostiek van "subtiele ovulatie-stoornissen". De kosten waard?
Ned. Ver. voor Fertiliteitstudie, Nov 1995.
Y.E.M. Snel, R-J.M. Brummer, M.E. Doerga, P.M.J. Zelissen, H.P.F. Koppeschaar
Validation of extracellular water, assessed by bioelectrical impedance analysis, in growth hormonedeficient adults
18th International Symposium on Growth Hormone and Growth factors in Endocrinology and
Metabolism, Gothenburg, 21-22 oktober 1994.
Endocrinol Metab 1995; 2 (suppl B), 146.
Y.E.M. Snel, R-J.M. Brummer, M.E. Doerga, P.M.J. Zelissen, C.J.G. Bakker, M.J. Hendriks, H.P.F.
Koppeschaar
Adipose tissue, assessed by magnetic resonance imaging, in growth hormone-deficient adults: the
effect of growth hormone replacement
18th International Symposium on Growth Hormone and Growth factors in Endocrinology and
Metabolism, Gothenburg, 21-22 oktober 1994.
Endocrinol Metab 1995; 2 (suppl B), 146.( poster price for best clinical study)
Y.E.M. Snel, R-J.M. Brummer, M.E. Doerga, P.M.J. Zelissen, C.J.G. Bakker, M.J. Hendriks, H.P.F.
Koppeschaar
Comparison between magnetic resonance imaging and anthropometry in growth hormone-deficient
adults
18th International Symposium on Growth Hormone and Growth factors in Endocrinology and
Metabolism, Gothenburg, 21-22 oktober 1994.
Endocrinol Metab 1995; 2 (suppl B), 145.
Y.E.M. Snel, R-J.M. Brummer, M.E. Doerga, P.M.J. Zelissen, C.J.G. Bakker, M.J. Hendriks, H.P.F.
Koppeschaar
Adipose tissue, assessed by magnetic resonance imaging and anthropometry in growth hormonedeficient adults: the effect of growth hormone replacement and a comparison with healthy controls
29th Annual Scientific Meeting of the European Society for Clinical Investigation, Cambridge, 2-5 april
1995.
Eur J Clin Inv 1995; 25, suppl. 2: A55
Curriculum Vitae – Hans Koppeschaar
33
Y.E.M. Snel, M.E. Doerga, R-J.M. Brummer, P.M.J. Zelissen, M.J. Zonderland, H.P.F. Koppeschaar
Resting metabolic rate, body composition and related hormonal parameters in growth hormonedeficient adults before and after growth hormone replacement therapy
19th International Symposium on Growth Hormone and Growth factors in Endocrinology and
Metabolism, Praag, 21-22 april 1995.
Acta Paedr 1995, suppl. 411: 123.
J.J.M. Deijns, J.M.H. de Klerk, H.P.F. Koppeschaar, P.M.J. Zelissen, Th.J.M.V. van Vroonhoven, J.W.
van Isselt, P.P. van Rijk
Ablatie met hoge dosis jodium-131-NaI na thyreoidectomie wegens goed gedifferentieerd
schildkliercarcinoom
Wetenschappelijke vergadering Nederlandse Vereniging voor Nucleaire Geneeskunde, Groningen, 20
mei 1995.
P.M.J. Zelissen, V.A. Heijnen, H.P.F. Koppeschaar, E.H.F. de Haan, R. Hijman
Neuropsychological profile in growth hormone deficient adults: preliminary results
20th International Symposium on Growth Hormone and Growth factors in Endocrinology and
Metabolism, Berlijn, 29-30 september 1995.
Abstract D3, pagina 102.
H.P.F. Koppeschaaar, H., A. Bernards, M. de Rooij, J. Thijssen and W. de Vries: Exercise induced
responses of growth hormone, insulin-like growth factor-1, and IGF-binding protein-3. Medicine and
Science in Sports and Exercise, 28:5, S4, 1996.
W. de Vries, A. Bernards, M. de Rooij, J. Thijssen, H. van Rijn and H. Koppeschaar: Different
responses of stress-related hormones to dynamic exercise. Medicine and Science in Sports and
Exercise 28:5, S76, 1996.
H.P.F. Koppeschaar, A. Nooitgedagt, A. Sidorowicz, C. Dieguez, F. Mallo, P.M.J. Zelissen, W.R. de
Vries
Neuroendocrine regulation of exercise induced growth hormone release: the role of pyridostigmine
and growth hormone-releasing peptide-6 (GHRP-6)
10th International Congress of Endocrinology, San Francisco, 12-15 juni 1996.
Program and Abstracts Book: P3-63, 770.
P.M.J. Zelissen, W.R. de Vries, A.N. Bernards, J.H.H. Thijssen, M.A. Blankenstein, H.P.F.
Koppeschaar
Response of salivary, urinary, and serum testosterone/cortisol ratio to acute exercise
10th International Congress of Endocrinology, San Francisco, 12-15 juni 1996.
Program and Abstracts Book: P2-433, 513.
M.E. Doerga, J.M.H. de Klerk, M.S. van Leeuwen, A. van de Biezenbos, P.M.J. Zelissen, C.J.M. Lips,
Th.J.M.V. van Vroonhoven, H.P.F. Koppeschaar
Predictive value of preoperative localization of insulinomas
10th International Congress of Endocrinology, San Francisco, 12-15 juni 1996.
Program and Abstracts Book: P3-659, 919.
C.J.M. Lips, H.P.F. Koppeschaar, J.W.M. Höppener, C.O. van Waveren Hogervorst, M.J.H. Berends,
P.M.J. Zelissen, J. Jansen-Schillhorn van Veen, Th.J.M.V. van Vroonhoven, Th.M. Vroom Expression
of the multiple endocrine neoplasia syndrome type 1 in a large family in The Netherlands. Strategies in
early detection and treatment of endocrinopathies
10th International Congress of Endocrinology, San Francisco, 12-15 juni 1996.
Program and Abstracts Book: P3-650, 917.
S.P. McKenna, H.P.F. Koppeschaar, P.M.J. Zelissen, Y.E.M. Snel
The impact of replacement of GH on the quality of life of patients; results of a clinical trial in the
Netherlands . Endocrinol Metab 1997, 4(suppl B):168
Curriculum Vitae – Hans Koppeschaar
34
W.R. de Vries, E.J. Thimister, M.E. Doerga and H.P.F. Koppeschaar: Exercise tolerance in adults with
growth hormone deficiency. Medicine and Science in Sports and Exercise 29:5, S 282, 1997.
H.P.F. Koppeschaar Regulatie en secretie van groeihormoon (GH): effecten op
lichaamssamenstelling en metabolisme, in het bijzonder bij GH-deficiente volwassenen. Paper read at
Lustrumcongres Nederlandse Vereniging van Klinische Chemie, juni, 1997. Ned Tijdscr Klin Chem
1997, vol 22, no 3, 93
A. Aleman, H.J.J. Verhaar, M.M. Samson, E.H.F. de Haan, W.R. de Vries, and H.P.F. Koppeschaar:
Groeihormoon en cognitief functioneren bij gezonde oudere mannen. Wetenschapsdag van de
Nederlandse Vereniging voor Geriatrie, december 1997.
C.B. Brouwer, J.K. Olijhoek, M.B. Rookmaaker, H.P.F. Koppeschaar, P.M.J. Zelissen
Dynamic tests for growth hormone deficiency (GHD) on 2 occasions after transshenoidal surgery for
clinically non-functioning pituitary adenoma
8th Meeting of the European Neuroendocrine Association, Marseille, 11-13 september 1997.
Ann Endocrinol 1997; 58, suppl. 1: 117.
P. Burman, A. Sietnieks, P. Öhagen and the Study Group for adult GHD (waaronder P.M.J. Zelissen,
H.P.F. Koppeschaar)
Patients with isolated GH deficiency have a similar responsiveness to GH treatment as patients with
multiple pituitary hormone deficiencies
8th Meeting of the European Neuroendocrine Association, Marseille, 11-13 september 1997.
Ann Endocrinol 1997; 58, suppl. 1: 119.
P.M.J. Zelissen, H.P.F. Koppeschaar
The Dexamethasone-Corticotropin Releasing Hormone (CRH) test differentiates accurately between
Cushing's syndrome and central morbid obesity
Annual Conference of the North American Association for the study of Obesity, Cancún, Mexico, 9-13
november 1997.
Obesity Res. 1997; 5, suppl. 1: 88S.
W.R. de Vries, T.J. Schers, S. Ait Abdesselam, I. Maitimu, J.C.M. Maas, H.P.F. Koppeschaar: Highintensity exercise enhances growth hormone (GH) secretion by a GHRH-dependent mechanism.
ACSM 45th Annual Meeting, Orlando, Florida, Medicine and Science in Sports and Exercise 30(5):
S49, 1998.
A. Aleman, H.J.J. Verhaar, E.H.F. de Haan, M.M. Samson, W.R. de Vries and H.P.F. Koppeschaar:
Serum IGF-1 and DHEAS, markers of cognitive aging? The 5th International Pituitary Congress,
Naples, Florida, 1998, (abstract).
H.P.F. Koppeschaar
Diagnostiek Hypofysetumoren
Paper read at Symposium Hypofysetumoren: Diagnostiek en Behandeling
e
10 Internistendagen, 23-24 april, 1998, Kongrescentrum Koningshof Veldhoven.
H.P.F. Koppeschaar
Mortality and Safety during GH treatment. 26th International Symposium
GH and Growth Factors in Endocrinology and Metabolism, October 23-24,1998, Palacio de
Congresos, Palma de Mallorca
A. Aleman, H.J.J. Verhaar, E.H.F. de Haan, M.M. Samson, W.R. de Vries and H.P.F. Koppeschaar:
Growth hormone and cognitive function in healthy older men. Growth Hormone and IGF Research
8(4): 329 (abstract) 1998.
P. Burman, A. Sietnieks, P. Öhagen, P.M.J. Zelissen, H.P.F. Koppeschaar, et al., on behalf of the
Study Group for adult GHD.
Predicting the response to growth hormone (GH) treatment - experience in 709 adults with GH
deficiency
80th Annual Meeting of The Endocrine Society, New Orleans, 24-27 juni 1998, OR31-3, pagina 93.
Curriculum Vitae – Hans Koppeschaar
35
Zonneveld. P, Scheffer, G.J., Koppeschaar, H.P.F., Fauser, B.C.J.M., te Velde, E.R.
Induction of Ovulation with clomiphene citrate: new insights into hormonal response
Human Reprod, 13, 338,1998
W.R. de Vries, C.A.M. Roelen, G.H. Donker, I. Maitimu, H.P.F. Koppeschaar: Effects of exercise and
growth hormone-releasing peptide-6 on growth hormone-binding protein. ACSM 46th Annual Meeting,
Seattle Washington, Medicine and Science in Sports and Exercise 31(5): S229, 1999.
H.P.F. Koppeschaar
GH and IGF-1 and Cognitive functions. Paper read at International Symposium GH and Growth
Factors in Endocrinology and Metabolism, Boston , U,S.A.,October 22-23, 1999
J. van Honk, A. Tuiten, E. Hermans, P. Putman, H. Koppeschaar, J. Thijssen, R. Verbaten, and L. van
Doornen: Exogenous testosterone elevates defensive heart rate reflexes to angry faces in young
women. 39th Annual Meeting Psychophysiology: Granada, Spain, 1999. Psychophysiology.,36
(S118).
Tuiten, J. van Honk, A. d’Alfonso, H.P.F. Koppeschaar, R. Verbaten, E.H.F. de Haan. A time course
effect of testosterone on autonomous sexual responding in human females. J. Cogn. Neurosci.
(Suppl), 11, 84, 1999.
B-Å. Bengtsson, H.P.F. Koppeschaar, R. Abs, H. Bennmarker, J.P. Monson, U. Feldt-Rasmussen et
al: Growth hormone replacement therapy is not associated with any increase in mortality. 81st Annual
Meeting of the Endocrine Society, June 12-15, San Diego, California, OR14-4, p.81, 1999.
Th.B. Twickler, D.W. Erkelens, P.M.J. Zelissen, H.P.F. Koppeschaar, M. Castro Cabezas: Increased
diurnal triglyceride profiles in growth hormone deficiency are independent of dietary fat intake. 81st
Annual Meeting of the Endocrine Society, June 12-15, San Diego, California, P3-140, p.467, 1999.
J.P. Monson, H.P.F. Koppeschaar, et al., on behalf of the KIMS Study Group and the KIMS Scientific
Board: Growth hormone deficiency and replacement in elderly hypopituitary adults. Annual Meeting of
the British Endocrine Society, 1999.
H.P.F. Koppeschaar, B-Å. Bengtsson, et al., on behalf of the KIMS Study Group and the KIMS
Scientific Board: Mortality and safety during growth hormone replacement therapy in adult GHdeficient patients. Annual Meeting ESPE'99, Warsawa, Poland, August 30-September 2, 1999.
U. Feldt-Rasmussen, H.P.F. Koppeschaar, et al., on behalf of the KIMS Study Group and the KIMS
Scientific Board: Growth hormone deficiency in patients treated for acromegaly or Cushing's disease.
Meeting European Neuroendocrine Association, Copenhagen, September 2-5, 1999.
A. Moschetta, G.P. van Berge-Henegouwen, M. Castro Cabezas, Th.B. Twickler, H.P.F. Koppeschaar,
G. Palasciano, K.J. van Erpecum: Growth hormone (GH) is a key factor for normal postprandial
gallbladder (GB) contractility and cholecystokinin (CCK) release. Gastroenterology 116:G4544, AGA
abstracts, 1999.
A.Moschetta, M.F.J. Stolk, N.M.A. van Ooteghem, P. Portincasa, M. Castro Cabezas, H.P.F.
Koppeschaar, P.H.Th.J. Slee, K.J. van Erpecum, G.P. van Berge-Henegouwen: Severe impairment of
gallbladder (GB) emptying in acromegalic patients after intramuscular depot administration of the longacting somatostatin analogue Sandostatin-LAR. Gastroenterology 116:G0094, AGA abstracts, 1999.
P. Wilton, H.P.F. Koppeschaar. Mortality and safety during growth hormone replacement therapy in
adult GH-deficient patients. Horm Res 1999; 51(Suppl 2): 143.
M.P.Mourits, M.L. van Kempen-Harteveld, M.G.C. Garcia, H.P.F.Koppeschaar,L.Tick, C.B. Terwee
Radiotherapy for Graves’ orbitopathy: randomised placebo-controlled study. American Journal of
Opthalmolology, 2000 ; 130 (3) : 382.
Curriculum Vitae – Hans Koppeschaar
36
P.S. van Dam, H. Smid, M. Niesink, E. Bolscher, C. Dieguez, W.R. de Vries, and H.P.F. Koppeschaar:
Stimulated growth hormone secretion in elderly men after reduction of free fatty acids by acipimox.
Growth Hormone & IGF Research 2000, Supplement B,138
W.R. de Vries, G.M. Lambers, D.P. van Zanten, I. Maitimu, and H.P.F. Koppeschaar: Growth hormone
responses to strenuous exercise are mediated by different pathways. 47th Annual Meeting ACSM,
Indianapolis, Medicine & science in Sports & Exercise , 2000 vol 32, 5, 844.
Tuiten A., Van Honk J., d’Alfonso A., Koppeschaar H., Verbaten R., de Haan E.
A time course effect of testosterone on autonomous sexual responding in human females
Journal of Cognitive Neuroscience, 2000, Suppl, 68A
Lambers AC, Koppeschaar HPF, Isselt JW van, Meulenbelt J.
The effect of nitrate on the thyroid gland . Oral presentation(XX EAPCCT International Congress 2-5
May 2000, Amsterdam, Congress Abstract Book, Clinical Toxicology.
P.S. van Dam, W.R. de Vries H. Smid, M. Niesink, E. Bolscher, C. Dieguez, FF Casanueva and HPF
Koppeschaar. GHRH- and GHRP-2 stimulated growth hormone secretion in elderly men after
reduction of free fatty acids by acipimox. Annual Meeting Endocrine Society, June 2000, Toronto,
Price winning abstract)
Th.B Twickler, G.M. Dallinga, H.P.F. Koppeschaar, P.M.J. Schreuder, P.S. van Dam, P.M.J. Zelissen,
M. Castro-Cabezas, D.W. Erkelens. Postprandial lipoprotein remnant levels decreased during
treatment with growth hormone in adult-onset growth hormone deficient patients (AGHD) Endocrine
Soc Meeting Toronto, 2000
Th.B Twickler, H.P.F. Koppeschaar, G.M. Dallinga-Thie, P.M.J. Zelissen, P. Schreuder, J. Jansen, M.
Castro-Cabezas, D.W. Erkelens
Postprandial remnant levels are increased in active acromegaly, Endocrine Soc Meeting, Toronto,
2000
H.P.F. Koppeschaar
Lipase-remming in de behandeling van adipositas , Paper read at Ned Ver voor Gastro-Enterologie.
Obesitas Symposium, Sectie voor Voeding en Metabolisme, Koningshof, Veldhoven,17-3 2000,
H.P.F. Koppeschaar
Growth Hormone Regulation From Young to Old, Paper read at Endocrinologie Symposium, 6 april
2000, UMCU, Utrecht
H.P.F. Koppeschaar
Behandeling van de Ziekte van Graves’ , Paper read at
Symposium : Multidisciplinaire Behandeling Orbitopathologie
UMCU, 15 april 2000, Slot Zeist, Zeist.
J. Keizer, J.M. de Klerk, H.P.F. Koppeschaar, P.M.J. Zelissen, and C.M.J. Lips
High therapeutic dosages of radioiodine in differentiated thyroid cancer patients with detectable serum
thyroglobulin. The Journal of Nuclear Medicine, may 2000, 41, number 5 (supplement) 308P
P.S. van Dam, M. Osman Dualeh, W.R. de Vries, C. Dieguez, F.F. Casanueva
and H.P,F. Koppeschaar
Effects of reduction of Free Fatty Acids on GHRH-stimulated GH release in adults after pituitary
surgery, 30th Int Symposium, GH and Growth Factors in Endocrinology and Metabolism, Monaco,
October 6-7, 2000
Feldt-Rasmussen U., Koppeschaar H.P.F., et al., on behalf of the KIMS Study Group: GH replacement
therapy decreases the use of health care resources and improves physical activity and QOL in GHD
th
adults. 11 International Congress of Endocrinology, Sydney Australia, 2000, P455, 207.
Curriculum Vitae – Hans Koppeschaar
37
Bengtsson B-A., Koppeschaar H.P.F., et al., on behalf of the KIMS Study Group: De novo neoplasm
th
during GH replacement in adults. Experience from KIMS. 11 International Congress of
Endocrinology, Sydney Australia, 2000, P457, 207.
Twickler Th.B., Visseren F.C.J., Dallinga-Thie G.M., Van Dam P.S., Castro-Cabesas M., Koppeschaar
H.P.F. Pro-inflammatory response induced through intestinal derived TG rich particles (TRP) in AGHD.
Atherosclerosis 2000, Suppl 151; P11: 31.
W.R. de Vries, E.J. Waasdorp, H.E.C. Smid, I. Maitimu, C.Y. Bowers, and H.P.F. Koppeschaar
Interaction of growth hormone-releasing peptide-2 (GHRP-2) with exercise-induced GH release.
th
ACSM 48 Annual Meeting, Baltimore, Medicine & Science in Sports & Exercise 33(5): S287, 2001.
P.S. van Dam, C. Dieguez, M.O. Dualeh, W.R. de Vries, F.F. Casanueva, and H.P.F. Koppeschaar
Diagnosis of growth hormone deficiency after pituitary surgery: the acipimox/GHRH test. 83th Annual
Meeting of the Endocrine Society, Denver, Colorado, S355, 2001.
Monson J.P., Koppeschaar H.P.F., et al., on behalf of the KIMS Study Group: Baseline characteristics
and treatment rin GHDA patients. Differences between countries. British Endocrine Society, March
2001.
Abs R., Koppeschaar H.P.F., et al., on behalf of the KIMS Study Group: Effect of GH replacement
therapy upon the lipid profile in a large cohort of hypopituitary patients with GH deficiency: the
experience from KIMS. EFES, June 2001; Endocrinology, June 2001.
Wilton P., Koppeschaar H.P.F., et al., on behalf of the KIMS Study Group: Safety of GH treatment in
adult GHD. Results from KIMS. Endocrinology, June 2001.
H.P.F. Koppeschaar. Age-sensitive cognitive function and the growth hormone/insulin-like growth
factor-1 axis in healthy aging. Cytokines and the aging brain. Symposium Neuropsychopharmacologie
nd
rd
INSERM, Bordeaux, France, Arcachon, 2 –3 June, 2002.
Th.B. Twickler, G.M. Dallinga-Thie, F.L.J. Visseren, W.R.de Vries, D.W. Erkelens, H.P.F.
Koppeschaar. Pronounced postprandial pro-inflammatory reponse in adult-onset GH deficiency is
associated with increased postprandial lipoprotein remnant profile. Key factor in pro-atherogenic
phenotype? Symposium Cardiology INSERM, Paris, France, Arcachon, June 2002.
M. Lijffijt, A. Wittenberg, R. de Vries, P.S. van Dam, H.P.F. Koppeschaar, M.L. Drent, J.L. Kenemans,
M.N. Verbaten. Selective attention and growth hormone deficiency: performance and
electrophysiology.
Sixth Dutch Endo-Neuro Meeting. Doorwerth, June 4-7, 2002.
Hans.P.F Koppeschaar, P.Sytze van Dam, Wouter R.de Vries, Andre A. Aleman, Edward H.F.de
Haan, J.Leon Kenemans, Marijn Lijffijt. Growth Hormone, Insulin-like Growth Factor-I and Cognitive
Function in Adults. International College of Geriatric PsychoNeuroPharmacology. Second Annual
Meeting,October 10-12,2002,Barcelona,Spain
P.Sytze van Dam, M.Lijffijt, A.Wittenberg, R.de Vries, C.F.de Winter, M.L.Drent, J vd Grond,
M.N.Verbaten, J.L.Kenemans, A.Aleman, E.H.F.de Haan and H.P.F.Koppeschaar. Cognitive function,
selective attention, event-related potentials and 1H magnetic resonance spectroscopy in childhoodonset growth hormone deficiency. 34th International Symposium GH and Growth Factors in
Endocrinology and Metabolism, 25-26, 2002, Budapest, Hungary
F.Verburg, B.de Keizer, C.L.J.J. Kruitwagen, P.M.J. Zelissen,.H.P.F. Koppeschaar,.C.J.M. Lips,.J.M.H.
de Klerk. Thryroglobulin levels at the time of J131 ablation are the only explanatory variable for
disease free survival in differentiated thyroid cancer and can be used to exclude the presence of
distant metastasis. Eur J Nucl Med 29; S182-S183, 506, 2002
Hans P.F. Koppeschaar, P. Sytze van Dam, Andre Aleman, Edward H.F. de Haan, Wouter R de Vries
Age-Sensitive Cognitive Function and the Growth Hormone/Insulin-like Growth Factor 1 Axis in
Healthy Aging J Clin Psychiatry 63:11,1070, 2002
Curriculum Vitae – Hans Koppeschaar
38
M Lijffijt, P.S. van Dam, A. Wittenberg, J.L. Kenemans, H.P.F. Koppeschaar, M.N. Verbaten The effect
of the neuroendocrine system on the brain: Growth hormone and its influence on selective attention as
indexed by performance and brain potentials J of Pscychophysiology, 17,3, 138, 2003
M. Den Hartog, M. van Kuijck, A. Mattson, M. Koltowska –Haggstrom, H.P.F.Koppeschaar
Improvement in quality of life and healthcare utilization during growth hormone replacement therapy in
th
hypopituitary adults : the Dutch KIMS experience. The Endocrine Society’s 85 Annual Meeting 2003
Jun 19-22; Philadelphia, USA, 594, P3-504
M.Den Hartog, M. van Kuijck. H.P.F. Koppeschaar, A.Matson, M. Koltowska Haggstrom
Significant improvement in Quality of Life and Health Care Consumption in hypopituitary adults in
the Netherlands. ISPOR,2003
P.S.van Dam, M.Lijffijt, A.Wittenberg, C.F.de Winter, M.L/ Drent, J van der Grond, J.L. Kenemans,
A.Aleman, E.H.F. de Haan, H.P.F. Koppeschaar Cognitive function,selective attention, event-related
Potentials and1H magnetic resonance spectroscopy in childhood-onset growth hormone deficiency
Eight International Pituitary Congress, Pituitary tumors: Back to basics, June 22-25, 2003, WaldorfAstoria, New York City, P 52, P30
P.S. van Dam, S.V. Haijma, W.R. de Vries, I. Maitimu, C. Diequez, F.F. Casanueva, H.P.F.
Koppeschaar
The GHRH+GHRP-6 test in healthy elderly and obese: implications for the diagnosis of growth
hormone deficiency Eight International Pituitary Congress, Pituitary tumors: Back to basics, June 2225, 2003, Waldorf-Astoria, New York City , P54, P33
A.M. Pereira, H.P.F. Koppeschaar, S.W. van Thiel, J. van Doorn, N.R. Biermasz, F. Roelfsema, and
J.A. Romijn
Long-term Safety and Efficacy of Needle-Free Growth Hormone Therapy in Adults with Growth
Hormone Deficiency ,2004, Endocrine Society June 2004, New Orleans, USA
J.Roose, W.R. de Vries, S.L. Schmickli, H.P.F.Koppeschaar, F.J.G.Backx, L.J.P. van Doornen
Evaluation of performance in Adolescent runners as a possible link to overtraining
2005,ACSM,Tenessee,USA
W.R. de Vries, S.L. Schmikli, P.C.J. Vergouwen, H.p.F. Koppeschaar, J.H.H. Thijssen, F.J.G. Backx
Modelling of Staleness-Related Maladaptation in Elite Male Athletes
2005, ACSM, Tenessee, USA.
E.B. Conemans, P.S. van Dam, W.M. Creyghton, I. Maitimu-Smeele, W.R de Vries, G.D. Valk, A.
Aleman, H.P.F. Koppeschaar
The growth hormone/Insulin-like growth factor-I axis and cognitive function in elderly men
Neuropsychoendocrinology meeting, may 30-31, 2005, Doorwert, Netherlands.
M. Koltowska -Haggstrom, J.Dorrestijn, M. Pompen, H.Montaban, A.Mattson, H.P.F.Koppeschaar
Sustained improvement in patient-reported outcomes (PRO) and normalization of healthcare utilization
(HCU) during growth hormone (GH) replacement therapy in hypopituitary adults in the Netherlands
European ISPOR (European Society for Pharmaeconomics and Outcomes Research) Florence,Italy,
6-8 November 2005 Value in Health vol 8, issue 6, 118,2005
E.H.Quik, E.B. Conemans, G.D. Valk, J.L. Kenemans, H.P.F.Koppeschaar & P.S. van Dam
GH secretion is associated with cognitive performance in older men with mild cognitive defects
Psychoneuroendocrinology Meeting Doorwerth, Netherlands, June 2007.
E.H. Quik, G.D.Valk, M.L.Drent, L.Kenemans, H.P.F.Koppeschaar, S.van Dam Cognitive performance
is associated with growth hormone secretion in patients who received radiation therapy in the brain
Neuroscience 2008
Curriculum Vitae – Hans Koppeschaar
39
E.H.Quick, G.D.Valk, M.L.Drent, J.L.Kenemans, H.P.F.Koppeschaar & P.S. van Dam
Divergent impact on cognition of growth hormone and insuli-like growth factor-I in subjects with GHD
after radiotherapy to the brain EndoNeuroMeeting, 2009, Doorwert, the Netherlands
I.C. van Nieuwpoort, C.C. van Bunderen, L.I. Arwert, A.A.M.Franken, H.P.F.Koppeschaar, A.J. van der
Lelij, J.W.R. Twisk, M.Boers, M.L. Drent Dutch national registry of growth hormone treatment in
adults-diagnostic procedures Nederlandse Endocrinologiedagen, NVE, januari 2010
IC van Nieuwpoort, CC van Bunderen, LI Arwert, AAM Franken, HPF Koppeschaar, AJ vander Lelij,
JWR Twisk, M Boers, and ML Drent Dutch National Registry of Growth Hormone Treatment in AdultsDiagnostic procedures Abstract Endocrine Society Meeting, San Diego, USA, June 2010
Christa C. van Bunderen, I.Caroline van Nieuwpoort, Lucia I. Arwert, Martijn W. Heymans, Anton A.M.
Franken, Hans.P.F.Koppeschaar, Aart J. van der Lely, Madeleine L.Drent Does Growth Hormone
Replacement Therapy reduce Mortality in Adults with Growth Hormone Deficiency? – Data from the
rd
Dutch National Registry of Growth Hormone Treatment in Adults 93 Annual Meeting of the
Endocrine Society ,Boston, USA, June 2011 (Outstanding Abstract Award)
D.Hohle, C.R.C.Pieterman, G.D. Valk, A.R.Hermus, H.P.F.Koppeschaar, J-J. CH. Meyer and R.P.J.
de Lange Classifying the decision to perform surgery in MEN1 cancer patients using decision trees
th
The 24 International Symposium on Computer-based Medical Systems, June, 2011, Bristol, UK
Gerritsen J, van Ham D.M.M, Bloemers J.M.M, Bocker K.B.E, Koppeschaar H.P.F, Everaerd W.T.A.M,
Tuiten J.A.A Testosterone, combined with sildenafil, enhances startles evoked during erotic pictures in
th
sexually dysfunctional women with high sensitivity for sexual cues 9 Dutch Endo-Neuro-Pschycho
Meeting, Lunteren, The Netherlands, 2011
N.C. van Varsseveld, A.S.H. de Jong, C.C. van Bunderen, A.A. Franken, H.P. Koppeschaar, A.J. van
der Lely, M.L. Drent Radiotherapy and growth hormone replacement therapy in growth hormone
deficient adults with craniopharyngeoma: preliminary data from the Dutch National Registry of Growth
th
Hormone Treatment in Adults 6 International Congress of the GRS & IGF Society, Munich,
Germany, october,2012
B. de Lange, D.Hohle, C.R.C. pieterman, G.D.Valk, A.R.Hermius, H.P.F.Koppeschaar, J.J.Meyer
Classifying the decision to perform surgery in MEN1 cancer patients using decision trees
th
24 JEEE Int Symp on computer-based Medical Systems, 2013
Christa C. van Bunderen, Carline J. van den Dries, Anton A.M. Franken, Hans P.F. Koppeschaar, Aart
J van der Lely, Madeleine L. Drent Evolving Pituitary Deficiencies in Adults with isolated Growth
Hormone Deficiency- a Sub Analysis from the Dutch National Registry of Growth Hormone Treatment
in Adults Endocrine Society Meeting, June 2013, San Francisco, USA
Christa C. van Bunderen, Carline J. van den Dries, Anton A.M. Franken, Hans P.F. Koppeschaar, Aart
J. van der Lely, Madeleine L. Drent Is there a Difference in Clinical Presentation between Adults with
Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiencies ? – A Sub Analysis
from the Dutch National Registry of Growth Hormone Treatment in Adults Endocrine Society Meeting,
June 2013, San Francisco, USA
Christa C. van Bunderen, Carline J. van der Dries, Martijn W. Heymans, Anton A.M.Franken, Hans
P.F.Koppeschaar, Aart J. van der Lely, Madeleine L. Drent The Effect of Long-Term Growth Hormone
Replacement Therapy on Cardiovascular Outcomes in Isolated Growth Hormone Deficiency compared
to Multiple Pituitary Hormone Deficiencies- A Sub-Analysis from the Dutch National Registry of Growth
Hormone Treatment in Adults (NVE, 2014)
Curriculum Vitae – Hans Koppeschaar
40