Pathology of Pulmonary Infections Prof. Frank Carey Topics.. Pneumonia infection – abscess/bronchiectasis Tuberculosis The immunocompromised host Chronic Pneumonia Gr. “disease of the lungs” Infection involving the distal airspaces usually with inflammatory exudation (“localised oedema”). Fluid filled spaces lead to consolidation Classification of Pneumonia By clinical setting (e.g. community acquired pneumonia) By organism (mycoplasma, pneumococcal etc) By morphology (lobar pneumonia, bronchopneumonia) Organisms – influenza, parainfluenza, measles, varicella-zoster, respiratory syncytial virus (RSV). Common, often self limiting but can be complicated Bacteria Chlamydia, mycoplasma Fungi Viruses Lobar Pneumonia Confluent consolidation involving a complete lung lobe Most often due to Streptococcus pneumoniae (pneumococcus) Can be seen with other organisms (Klebsiella, Legionella) Clinical Setting Usually community acquired Classically in otherwise healthy young adults Pathology A classical acute inflammatory response Exudation of fibrin-rich fluid Neutrophil infiltration Macrophage infiltration Resolution Immune system plays a part antibodies lead to opsonisation, phagocytosis of bacteria Complications Organisation (fibrous scarring) Abscess Bronchiectasis Empyema Bronchopneumonia Infection starting in airways and spreading to adjacent alveolar lung Most often seen in the context of preexisting disease Clinical Context COPD Cardiac failure (elderly) Complication of viral infection (influenza) Aspiration of gastric contents Organisms varied – Strep. Pneumoniae, Haemophilus influenza, Staphylococcus, anaerobes, coliforms Clinical context may help. Staph/anaerobes/coliforms seen in aspiration More Complications Organisation Abscess Bronchiectasis Empyema Lung Abscess Localised collection of pus Tumour-like Chronic malaise and fever Context - aspiration Bronchiectasis Abnormal fixed dilatation of the bronchi Usually due to fibrous scarring following infection (pneumonia, tuberculosis, cystic fibrosis) Also seen with chronic obstruction (tumour) Dilated airways accumulate purulent secretions Tuberculosis Mycobacterial infection Chronic infection described in many body sites – lung, gut, kidneys, lymph nodes, skin…. Pathology characterised by delayed (type IV) hypersensitivity (granulomas with necrosis) Organisms M. tuberculosis/M.bovis main pathogens in man Others cause atypical infection especially in immunocompromised host. Pathogenicity due to ability; to avoid phagocytosis to stimulate a host T-cell response Immunity and Hypersensitivity T-cell response to organism enhances macrophage ability to kill mycobacteria this ability constitutes immunity T-cell response causes granulomatous inflammation, tissue necrosis and scarring this is hypersensitivity (type IV) Commonly both processes occur together Pathology of Tuberculosis (1) Primary TB (1st exposure) inhaled organism phagocytosed and carried to hilar lymph nodes. Immune activation (few weeks) leads to a granulomatous response in nodes (and also in lung) usually with killing of organism. in a few cases infection is overwhelming and spreads Pathology of Tuberculosis (2) Secondary TB reinfection or reactivation of disease in a person with some immunity disease tends initially to remain localised, often in apices of lung. can progress to spread by airways and/or bloodstream Tissue changes in TB Primary Small focus (Ghon focus) in periphery of mid zone of lung Large hilar nodes (granulomatous) Secondary Fibrosing and cavitating apical lesion (cancer an important differential diagnosis Why does disease reactivate? Decreased T-cell function age coincident disease (HIV) immunosuppressive therapy (steroids, cancer chemotherapy) Reinfection at high dose or with more virulent organism The immunocompromised host Virulent infection with common organism (e.g. TB) Infection with opportunistic pathogen virus (cytomegalovirus - CMV) bacteria (Mycobacterium avium intracellulare) fungi (aspergillus, candida, pneumocystis) protozoa (cryptosporidia, toxoplasma) Diagnosis High index of suspicion Teamwork (physician, microbiologist, pathologist) Broncho-alveolar lavage Biopsy (with lots of special stains!)