KIN 405: Medical Aspects of Sports Dermatology: Recognizing Illnesses and Disorders of the Skin Skin Lesions Often overlooked or trivialized Can signify serious disease in well patients Local conditions Systemic conditions Difficult for many health professionals to recognize Athletic Trainers’ Goals Recognize various forms of skin lesions Reassure patients that every little blemish is NOT skin cancer Refer for definitive diagnosis and treatment Restrict competition for athletes with communicable illness Presentation Outline Anatomy of the skin Types of lesions Rashes Infections – Bacterial – Fungal – Viral Presentation Outline (cont) Skin cancer Assessment techniques Treatment techniques Anatomy of the Skin Stratum corneum Epidermis Dermis Pilosebaceous unit Subcutaneous fat Stratum Corneum Top layer of skin Flakes off imperceptibly Barrier to noxious substances Totally replaced every 27 days Epidermis Protects against UV damage Provides cutaneous immunity Dermis Connective tissue Provides elasticity & strength Contains blood vessels, nerves, & sweat glands Skin splits when dermis is cut Pilosebaceous Unit Hair shaft Hair follicle Erector muscle Sebaceous gland Common site of bacterial infections Subcutaneous Fat Insulates Protects Kinds of Skin Lesions Macules Papules Plaques Pustules Vesicles Nodules Desquamination Bullae Ulcers Wheals Macules Flat Nonpalpable Discolored Less than 1cm Causes of Macules Hypopigmentation Hyperpigmentation Permanent vascular abnormalities of the skin Transient capillary dilatation (erythema) Hypopigmentation Macules Vitiligo Depigmentation Hyperpigmentation Macules Café-au-lait spots Permanent Vascular Abnormalities of the Skin CAPILLARY HEMANGIOMA OF INFANCY PORT-WINE STAIN Transient Capillary Dilatation (Erythema) Erythema Infectiosum (systemic viral) Papules Latin for “Pimple” Raised lesion Less than .5 cm Solid Example of Papules Rosacea Plaques Large, raised lesion Well-defined Confluence of multiple papules Chronic rubbing leads to “lichenification” (thickened skin) Example of Plaques PSORIASIS VULGARIS OF THE ELBOW Pustules Circumscribed Superficial Contains purulent exudate that may be – – – – white yellow greenish yellow hemorrhagic. Example of Pustules Acne Vulgaris Vesicles Latin for “little bladder” Fluid filled cavity Less than .5 cm Walls can be translucent Contains serum, lymph, blood, or extracellular fluid Example of Vesicles Nongenital herpes simplex virus (HSV) infection Bullae Latin for “bubble” Fluid filled cavity Greater than .5 cm Walls can be translucent Contains serum, lymph, blood, or extracellular fluid Diabetic bullae Nodules Latin for “small knot” Palpable, solid Round or ellipsoid Epidermal, dermal, or subcutaneous Generally deeper and larger than papules Example of Nodules Adult T-Cell Leukemia/Lymphoma Desquamination Proliferation of epidermis resulting in abnormally formed stratum corneum “Scaly” Large (membranous) or small (dust) Example of Desquamination Solar Keratosis Ulcers Pathologically altered tissue (different from a wound) Epidermal - heals w/out scar Dermal - heals w/ scar Example of Ulcers Stage IV Pressure Ulcer on Sacrum Wheals Hives Rounded or flat topped Pale red Transient Can change rapidly in size, shape, and location due to shifting edema in the dermis Example of Wheals Cutaneous Vasculitis Rashes Acne Dermatitis Intertrigo Urticaria Psoriasis Seborrheic dermatitis Pityriasis rosea Acne Affects 75% of the population Can involve inflammation of the pilosebaceous unit Food choices NOT causative Endocrine and emotional links Not contagious Four stages Grade I Acne Comedones (blackheads) Some whiteheads Topical antibiotics (clindamycin, erythromycin Benzoyl peroxide gels (2%,5%,10%) Tretinoin (Retin-A) creams Grade II Acne Erythematous papules Oral tetracycline antibiotics added to previous tx regimen For females, oral estrogens combined with progesterone or antiandrogens Grade III Acne Pustules Isotretinoin (Accutane) Contraception (2 forms) is absolutely necessary Do not combine tetracycline and isotretinoin Risk of psychiatric side effects Grade IV Acne Cysts Nodules Scars Dermatitis Inflammation of the skin Sometimes called eczema Many causes and forms (allergic vs non-allergic) Not contagious Contact dermatitis caused by contact with noxious substances (formaldehyde, plant oils, rubber, etc) Dermatitis-Signs and Symptoms Pruritis (itching) Erythematous papules Vesicles (or bullae) Crusting Edema Poison Ivy, 5 days post exposure Dermatitis-Treatment Identify and remove the etiologic agent Bullae may be drained, but tops should not be removed Cool compresses Topical corticosteroids Contact dermatitis from parabencontaining foot cream Dermatitis-Treatment (cont) In severe cases, systemic corticosteroids may be indicated Prednisone: twoweek course, 70 mg initially, tapering by 5 mg daily Chronic contact dermatitis on the hands of a concrete worker Intertrigo Caused by friction in skin folds Axilla, inframammary area, groin Gradual and progressive skin abrasion irritated by sweat and heat Intertrigo-Treatment Mild topical hydrocortisone Zinc oxide ointment Reduce friction Corn starch/baby powder Expose to air Urticaria Transient hives characterized by wheals Pruritis Caused by sunlight, medication or food allergy, cold, and exercise Urticaria Wheals with white-to-light-pink color centrally and peripheral erythema in a close-up view. Cholinergic Urticaria Exercise-induced wheals & pruritis Hot shower may also reproduce symptoms Urticarial papules on neck w/in 30 minutes of vigorous exercise Cold-Induced Urticaria Caused by cold sensitivity Ten minute application of ice pack cause a wheal w/in five minutes of the removal of the ice Urticaria-Treatment Oral antihistamines (Benadryl) Avoidance of causative agent Prednisone May compete as long as pruritis is not disabling & breathing not compromised Urticaria as it appeared 5 minutes after stroking the skin with a wooden stick. The patient had experienced generalized pruritus for several months with no spontaneously occurring urticaria. Psoriasis Genetically inherited disease Erythematous papules and plaques Primarily on extensor surfaces – elbows – knees – scalp – intergluteal area Psoriasis-Trigger Factors Trauma (Koebner effect) Drugs Stress Infections Psoriasis of the elbow Psoriasis-Treatment Limited course of topical corticosteroids (long term application causes skin breakdown) Triamicinolone acetonide (Aristocort, Kenalog) Psoriasis-Treatment (cont) Anthralin (AnthraDerm cream -- not for use on face or skin creases) Vitamin D analogues (e.g., calcipotriol) UV light therapy No participation restrictions Seborrheic Dermatitis Common chronic dermatosis Characterized by redness and scaling occurring in regions where the sebaceous glands are most active, such as the face and scalp, and in the body folds. Mild scalp SD causes flaking (dandruff) Seborrheic Dermatitis-Treatment Creams or shampoos containing – selenium (Selsun Blue) – ketocanazole (Nizoral) Similar lesions were also present in the retroauricular areas and presternal chest. Pityriasis Rosea Distinctive morphology Characteristic course “Herald” plaque lesion develops, usually on the trunk, and 1 or 2 weeks later a generalized secondary eruption develops in a typical distribution pattern Spontaneous remission in 6 weeks without any therapy Pityriasis Rosea (cont) Herald Patch (80 % of patients) oval, slightly raised plaque 2 to 5 cm, bright red, fine scale at periphery Pityriasis Rosea (cont) Long axes of the lesions follow the lines of cleavage in a “Christmas tree” distribution Lesions usually confined to trunk and proximal arms and legs Rarely on face Pityriasis Rosea-Treatment Pruritus may be controlled by UVB phototherapy or natural sunlight exposure if begun in the first week of eruption. Five consecutive exposures, starting with 80 % of the minimum erythema dose and increasing 20 % each exposure. Usually goes away by itself. Infectious Disorders Bacterial Infections Fungal Infections Viral Infections Bacterial Infections Impetigo & ecthyma Abscess, furuncle, & carbuncle Scarlet fever Impetigo & Ecthyma Caused by Staphylococcus aureus and Streptococcus pyogenes Impetigo-epidermis Ecthyma-dermis Scattered, discrete, thinSuperficial breaks in walled vesicles and bullae that the skin easily rupture and form erosions. Impetigo Transient superficial small vesicles or pustules, rupture resulting in erosions, which in turn become surmounted by a crust Crusted (golden-yellow, stuck-on) erosions becoming confluent on the nose, cheek, lips, and chin. Ecthyma Ulceration with a thick adherent crust A large, circumscribed ulcer with a necrotic base and surrounding erythema in the pretibial region. Impetigo & Ecthyma-Treatment Mupirocin (Bactroban) applied three times daily to involved skin and to nares for 7 to 10 days. Oral antibiotics (10 day course is typical) Highly infectious -- disqualify from contact athletics until infection is cleared by physician Abscess, Furuncle, & Carbuncle Abscess - a circumscribed collection of pus appearing as an acute or chronic localized infection with tissue destruction. Furuncle - an acute,deep-seated, red, hot, tender nodule or abscess that evolves from a staphylococcal folliculitis. Carbuncle - a deeper infection composed of interconnecting abscesses usually arising in several contiguous hair follicles. Abscess Usually caused by Staphylococcus aureus. Very tender Warm Will develop a pustulent head A very tender abscess with surrounding erythema on the heel. Furuncle (boil) Firm tender nodule 1 to 2 cm Central necrotic plug. staphylococcal folliculitis in beard area or neck. Nodule becomes fluctuant with abscess formation Furuncle (boil) Necrotic plug often topped by a central pustule. Following drainage a nodule. A zone of cellulitis may surround the furuncle. Carbuncle Evolution similar to that of furuncle. Comprised of multiple, adjacent, coalescing furuncles Characterized by multiple dermal and subcutaneous abscesses,pustules, necrotic plugs, and sieve-like openings draining pus Treatment Incision and drainage Systemic antibiotics (10 day course) Local heat Disqualification from contact sport until resolved Highly contagious Scarlet Fever Acute infection of the tonsils, skin, or other sites by Streptococcus Associated with a characteristic toxigenic rash Scarlet Fever Erythema on the upper trunk Face flushed with a perioral pallor. Linear petechiae (Pastia’s sign) occur in body folds. Rash fades w/in 5 followed sheetlike exfoliation on the palms and soles. Pastia’s Sign Scarlet Fever-Treatment Aspirin or acetaminophen for fever and/or pain The goal of therapy is to eradicate Streptococcus throat carriage to prevent rheumatic fever. Drug of choice is penicillin because of its efficacy in prevention of rheumatic fever. Desquamation of the volar fingertips 10 days after onset of streptococcal pharyngitis in an adult female. Fungal Infections Varieties of Tinea infections Onychomycosis Candidiasis Pityriasis versicolor Tinea Pedis (Athlete’s Foot) Dermatophytic infection of the feet Erythema,desquam ation, and/or bulla formation Hot, humid weather, occlusive footwear, Scaling, maceration, excessive sweating erythema, and erosion in the 4-5 webspace. 4th toenail also infected. Tinea Pedis (Athlete's Foot) Walking barefoot on contaminated floors Arthrospores can survive in human skin scales 12 months. Pruritus Pain with secondary bacterial infection Moccasin type tinea pedis. Erythema, fine white scaling of the plantar and lateral foot, and keratoderma(thickening of the keratin layer) Tinea Pedis-Treatment Keep feet clean, dry, exposed to air Dry shoes thoroughly Terbinafine (Lamisil) cream Tinea Manuum Fungal infection of the hands Diffuse hyperkeratosis of the palms (especially the creases) Patchy scaling on the dorsa and sides of fingers 50% of patients have unilateral involvement Erythema and scaling of the right hand, associated with bilateral tinea pedis; the “one hand, two feet” distribution is typical of epidermal dermatophytosis of the hands and feet. Tinea Manuum-Treatment Must eradicate all other sources of tinea infection Topicals don’t work (stratum corneum too thick) Terbinafine (Lamisil) Itraconazole (Sporanox) Griseofulvin (Grisactin) Tinea Cruris (Jock Itch) Subacute or chronic dermatophytosis of the groin, pubic regions,and thighs. Warm, humid environment, tight clothing worn by Erythematous, scaling plaques men, obesity. on the medial thighs,inguinal Pruritis folds, and pubic area. The margins are raised and sharply marginated. Tinea Cruris Most individuals with tinea cruris have tinea pedis. Dermatophyte is transferred from feet to crural region by hands. Affects groins and thighs. May extend to buttocks. Scrotum and penis are rarely involved. TOPICAL ANTIFUNGALS CATEGORIES Imidazoles Mycelex AGENTS Clotrimazole TRADE NAMES Lotrimin, Miconazole Micatin Ketoconazole Nizoral Econazole Spectazole Oxiconizole Oxistat Sulconizole Exelderm Allylamines Naftifine Naftin Terbinafine Lamisil Naphthiomates Tolnaftate Tinactin Substituted pyridone Ciclopiroxalamine Loprox Tinea Cruris-Treatment Eradicate other sources of tinea infection Differentiate from intertrigo Avoid tight clothing Keep dry, cool Tinea Corporis (Ringworm) Dermatophyte infections of the trunk, legs, and arms, excluding the feet, hands, and groin. More common in animal workers in tropical climates. Sharply marginated, hyperpigmented plaques of chronic duration. Associated tinea cruris and tinea pedis are usually present. Tinea Corporis Often asymptomatic Mild pruritus Scaling, sharply marginated plaques Peripheral enlargement and central clearing Annular Tinea corporis contracted configuration with from a pet guinea pig. concentric rings Tinea Corporis-Treatment CATEGORIES Imidazoles AGENTS TRADE NAMES Clotrimazole Lotrimin, Mycelex Miconazole Micatin Ketoconazole Nizoral Econazole Spectazole Oxiconizole Oxistat Sulconizole Exelderm Allylamines Naftifine Naftin Terbinafine Lamisil Naphthiomates Tolnaftate Tinactin Substituted pyridone Ciclopiroxalamine Loprox Tinea Facialis (Face Ringworm) Dermatophytosis of the glabrous facial skin Well-circumscribed erythematous patch More commonly misdiagnosed than any other dermatophytosis. Sharply marginated, erythematous plaque with some central clearing and peripheral scaling on the lower eyelid and cheek Tinea Facialis Pruritus and photosensitivity Pink to red In black patients, hyperpigmentation Scaling often is minimal but can be pronounced Sharply marginated, erythematous, scaling, and crusted plaques on the face of a child. Note asymmetry. Tinea Facialis-Treatment Topical antifungal preparations Eradicate dermatophyte infection at other sites such as feet and hands. Tinea Facialis is more common in children. Tinea Capitis Fungal infection of the scalp Follicular inflammation with painful, boggy nodules that drain pus Scarring alopecia Scaling patches Large, round, hyperkeratotic plaque of alopecia due to breaking off of hair shafts close to the surface, giving the appearance of a mowed wheat field on the scalp of a child. Tinea Capitis Blacks>whites Children>adults Three types – “Black dot” – Kerion – Favus Tinea Capitis-”Black Dot” Type Broken-off hairs near surface give appearance of “dots” in dark-haired patients Tends to be diffuse and poorly circumscribed Resembles seborrheic dermatitis. A subtle, asymptomatic patch of alopecia due to breaking off of hairs on the frontal scalp in a 4-year-old black child. Tinea Capitis-Kerion Type Boggy, purulent, inflamed nodules and plaques Usually extremely painful Drains pus from multiple openings Hairs do not break off but fall out and can be pulled without pain Heals with scarring alopecia. Large, very painful, inflammatory tumor with hair loss, studded with multiple pustules on the scalp of a young child. Tinea Capitus-Favus Type Thick yellow adherent crusts (scutula) Fetid odor Untreated results in cutaneous atrophy, scar formation, and scarring alopecia. Tinea Capitis-Treatment Topical antifungal agents are ineffective in management of tinea capitis Systemic antifungals should be used until symptoms have resolved and fungal cultures negative Terbinafine and itraconazole superior to ketoconazole and all three to griseofulvin. Side effects in increasing order: terbinafine < itraconazole < ketoconazole < griseofulvin Tinea Barbae- Ringworm of the Beard Fungal infection of the beard and moustache areas Adult males only More common in farmers Pruritus,tenderness, pain Scattered, discrete follicular pustules and papules in the moustache area, easily mistaken for S. aureus folliculitis. Tinea Barbae-Treatment Similar to tinea capitis Topical antifungals ineffective Systemic antifungals should be used until symptoms have Confluent, painful papules, resolved and fungal nodules, and pustules on the cultures negative upper lip. Tinea facialis present on the cheeks, eyelids, eyebrows,and forehead. Onychomycosis Toenail becomes opaque, thickened, cracked, friable, raised by underlying hyperkeratotic debris in the nail bed Toenails more common than fingernails When fingernails are involved, pattern is usually two feet and one hand Distal subungual hyperkeratosis and onycholysis involving most of the nail bed of the great toenails; these findings are usually associated with tinea pedis. Onychomycosis-Treatment Does not resolve spontaneously;involvement of multiple toenails is the rule. Relapse occurs in the majority of persons treated with griseofulvin. Relapse rate with itraconazole or terbinafine is less than with griseofulvin The proximal nail plate is a chalky white color due to invasion from the undersurface of the nail matrix. The patient had advanced HIV disease. Cutaneous Candidiasis Superficial infection occurring on moist cutaneous sites Many patients have predisposing factors that alter local immunity such as increased moisture at the site of infection, diabetes, or alteration in systemic immunity Erosions on the medial thighs, inguinal folds, and scrotum with “satellite” pustules and papules of an obese male. Cutaneous Candidiasis Cutaneous Candidiasis Penis/scrotum Vulva Fingernails Interdigital Treatment is primarily topical Erythematous eroded area with surrounding maceration in a webspace of the hand occurring in a health care worker is a type of intertrigo. Pityriasis Versicolor Also known as tinea versicolor Yeast infection Usually on the trunk Depigmentation of the skin Should not disqualify am athletes from participation Hypopigmented, sharply marginated, scaling macules on the shoulder area of an individual with brown skin. Gentle abrasion of the surface accentuates the scaling. Pityriasis Versicolor-Treatment Selenium sulfide (2.5%) lotion or shampoo: Apply daily for 10 to 15 minutes, followed by shower, for 1 week. Azole creams (ketoconazole, econazole, micronazole, clotrimazole): Apply b.i.d. for 2 weeks. Follicular, hypopigmented macules on the upper chest of an individual with black skin. Viral Infections Molluscum Contagiosum Herpes Warts Molluscum Contagiosum Epidermal viral infection Skin-colored papules Children and sexually active adults Transmission by skin-to-skin contact Discrete, solid, skin-colored papules, 1 to 2mm in diameter with central umbilication on the chest of an adolescent female. The lesion with an erythematous halo is undergoing spontaneous regression. Molluscum Contagiosum In healthy individuals resolves spontaneously. In HIV-infected individuals often progresses despite treatment. Painful aggressive therapy is best avoided. Avoid skin-to-skin contact Herpes Simplex Virus Three types – Nongenital – Genital – Herpes Gladiatorum Multiple painful erosions on the lower labial mucosa with erythema and edema of the gingiva; plaque has formed on the teeth because of pain within the lesions that restricts brushing. Fever and tender submandibular lymphadenopathy were also present. Nongenital Herpes Simplex – Grouped vesicles arising on an erythematous base on keratinized skin or mucous membrane – Lips most common – Incubation 3-12 days – Chronic and recurrent A. Grouped and confluent vesicles with an erythematous rim on the lips. B. Edema with crusting of the lips which followed sun exposure; vesiculation is present but difficult to detect because of confluence of lesions. In some cases, crusting is the only finding. Nongenital Herpes Simplex Restrict from athletics until lesions crusted and dry Acyclovir (Zovirax) 800 mg b.i.d. for 5 days Valacyclovir (Valtrex) 500 to 1000 mg b.i.d. Famciclovir (Famvir) Herpetic Whitlow-Painful, grouped, confluent vesicles on the volar finger on an erythematous edematous base. Genital Herpes Simplex – Grouped vesicles at the site of inoculation and inguinal Group of vesicles with early central lymphadenopathy crusting on a red base arising on the – Flu-like symptoms shaft of the penis. (myalgia, headache) Multiple, extremely – Chronic and painful, recurrent punched-out, – Oral antiviral meds confluent, shallow ulcers – May participate on the vulva unless they feel too and perineum. crummy Herpes Gladiatorum Spread of herpes to abraded of injured skin Associated with widespread dermatitis Looks like impetigo Oral antivirals Common in wrestlers No participation until cleared Herpes Zoster (Shingles) Chicken pox virus Distribution along dermatomes Painful Headache, malaise, fever Spontaneous resolution 2-3 weeks Analgesics, antivirals (acyclovir) Dermatomal, grouped and confluent vesicles and pustules arising in the third sacral dermatome; note extension of lesions 1–2 cm across the midline. Warts Caused by human papillomavirus (HPV) Three types – Common warts (verruca vulgaris70%) – Plantar warts (verruca plantaris30%) – Flat warts (verruca plana-4%) The thrombosed capillaries (brown dots) differentiate the lesion from a corn or callus. Common Warts (Verruca Vulgaris) Palmar lesions disrupt the normal line of fingerprints. Return of fingerprints a sign of resolution of the wart. Hands, fingers, knees. Hyperkeratotic papules becoming confluent around the periungual tissue of four fingers; the brown dots represent thrombosed capillaries. Plantar Warts (Verruca Plantaris) Plantar surface of feet Often solitary but may be three to six or more Pressure points, heads of metatarsal, heels, toes The warts are surrounded by nonwarty callus. Tinea pedis is also present in the webspaces and instep with sites of excoriation. Flat Warts (Verruca Plana) Always numerous discrete lesions, closely set Face, beard area, dorsa of hands, shins Flat-topped, pink papules with sharp margination and minimal hyperkeratosis on the dorsum on the hands and fingers. Wart Treatments Usually resolve sponatneously Painful plantar warts warrant more aggressive treatment 40% salicylic acid plaster for 1 week Cryosurgery Electrosurgery CO2 laser surgery Infestations Scabies Pediculosis Scabies Mites burrow beneath stratum corneum Undiagnosed pruritis Palms, wrists, ankles, nipples, ubilicus, genitals Acquired sexually or through crowded living conditions Papules and burrows in typical location on the finger webs. Burrows are tan or skin-colored ridges with linear configuration with a minute vesicle or papule at the end of the burrow and are often difficult to locate. Scabies No contact sports until cleared (1 wk) Examine sexual partners Wash bedding Lindane (Kwell, Scabene lotion or shampoo). Do not use after bathing, with pregnancy or lactation Permethrin (Nix lotion) A mite at the end of a burrow with 8 eggs and smaller fecal particles obtained from a papule on the webspace of the hand. Pediculosis (Lice) Pediculosis capitis Pediculosis pubis Pediculosis corporis Highly infectious Pruritis Regional lymphadenopathy Eggs (nits) adhere to hair A crab louse (see arrow) on the skin in the pubic region. Pediculosis (Lice) No contact sports until all nits removed Examine sexual partners Wash bedding Lindane (Kwell) Pyrethins (RID, R&C, A-200 gel, liquid, shampoo) Crab lice (see arrow) and nits on the upper eyelashes of a child; this was the only site of infestation. Skin Cancer Three major types – Basal cell carcinoma – Squamous cell carcinoma – Melanoma Oral Leukoplakia - The lesion, in a heavy pipe smoker, progressed to a verrucous carcinoma. Basal Cell Carcinoma Most common type of skin cancer. Locally invasive, aggressive, and destructive Limited capacity to metastasize Exposure to UV light Large, shiny, red nodule with a cobblestoned surface and an ulcerated nodule. Basal Cell Carcinoma Excision with primary closure, skin flaps, or grafts. Cryosurgery and electrosurgery Danger sites nasolabial area, around the eyes, ear canal, posterior auricular sulcus, scalp - microsurgery required Squamous Cell Carcinoma Less common than basal cell carcinoma Exposure to UV light and x-rays, arsenic Slowly evolving Cheeks, nose, lips, tips of ears, preauricular areas, scalp, dorsa of the hands, forearms, trunk, and shins (females) A large notch on the superior aspect of the helix, a nodule of SCC with hyperkeratosis and ulceration. Squamous Cell Carcinoma Any isolated keratotic or eroded papule or plaque in a suspect patient that persists for over a month is considered a carcinoma until proved other-wise. Squamous Cell Carcinoma Surgery Microscopically controlled surgery in difficult sites Radiotherapy should be performed only if surgery is not feasible Melanoma Most deadly kind of skin cancer Increasing rapidly Sun exposure? Thinning ozone layer? Assymetric,pigment ed, irregular, large lesions Suspicious nevi: Two large, variegated, brown oval macules. Melanoma Radial growth phase Vertical growth phase Critical to identify & treat early during radial growth phase The lighter macular portion of this lesion is a suspicious nevus on the upper back; the blue-black plaque is a superficial spreading melanoma (1.2 mm thickness). The patient was a 34year-old internist who died 36 months following detection and excision of this lesion. Melanoma Surgery is treatment Suspicious nevi (moles): – changing (increase in size, change in pigmentation pattern, changes in shape and/or border) – location that cannot be closely followed by the patient by self-examination (on the scalp, genitalia, upper back) Melanoma-The left image (1990) shows variegation of pigmentation and irregular borders. Five years later, the lesion (right) shows darkening of melanin pigmentation, more irregularity in shape, and elevation in the most darkly pigmented region. Six Warning Signs for Melanoma A ASYMMETRY in shape—one-half unlike the other half B BORDER is irregular—edges irregularly scalloped C COLOR is mottled—haphazard display of colors; shades of brown, black, gray, red, and white D DIAMETER is usually large—greater than the tip of a pencil eraser (6.0 mm) E ELEVATION is almost always present—surface distortion is assessed by side-lighting. ENLARGEMENT—a history of an increase in the size of lesion is perhaps one of the most important signs of melanoma Dermatology Assessment General Approach to Patients With Skin Signs and Symptoms Epidemiology and Etiology Age Race Sex Occupation History Duration of onset Relationship of skin lesions to season, travel history, heat, cold, previous treatment, drug ingestion, occupation, hobbies, effects of menses, pregnancy Skin symptoms: pruritus, pain, paresthesia History (cont) Constitutional symptoms – “Acute illness’’ syndrome: headaches, chills, feverishness, weakness – “Chronic illness’’ syndrome: fatigue, weakness, anorexia, weight loss, malaise Systems review Physical Examination Appearance of patient: uncomfortable, “toxic,’’ well Vital signs: pulse, respiration, temperature Skin—four major skin signs: (1) type, (2) shape, (3) arrangement, (4) distribution of lesions Types of Skin Lesions Macules Papules Plaques Pustules Vesicles Nodules Desquamination Bullae Ulcers Wheals Color and Palpation White Brown Purple Violet Red “Flesh” Consistency Temperature Mobility Tenderness Depth of lesion (i.e., dermal or subcutaneous) Shape Round Oval Annular (ring-shaped) Serpiginous (snakelike) Umbilicated Margination – well-defined (can be traced with the tip of a pencil) – ill-defined Arrangement Grouped Disseminated Distribution Extent – isolated (single lesions), – localized – regional – generalized – universal Pattern – – – – – – symmetrical exposed areas sites of pressure intertriginous area follicular localization random