Chapter 7

DSM-IV Definitions
Autistic Disorder marked by three defining features, with onset before age: 1) impaired social interaction, 2) impaired communication, and 3) restricted, repetitive, and stereotyped patterns of behavior, interests, and activities
Asperger Syndrome impairments in all social areas, particularly an inability to understand how to interact socially
Rhett’s Syndrome a distinct neurological condition that begins between 5 and
30 months of age, marked by a slowing of head growth, stereotypic hand movements, and severe impairments in language and coognitive abilities
Childhood disintegrative disorder shares characteristics with autistic disorder, but doesn’t begin until after the age of 2 and sometimes not until age 10
Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) diagnosis given to children who meet some, but not all, of the criteria for autistic disorder.

IDEA Definition
Autism is a developmental disability affecting verbal and nonverbal communication and social interaction, generally before age 3, that adversely affects a child’s performance.

Characteristics
• Impaired social relationships
• Many children with autism do not speak. Echolalia is common among those who do talk
• Varying levels of intellectual functioning, uneven skill development
• Unusual responsiveness to sensory stimuli
• Insistence on sameness
• Ritualistic and stereotypic behavior
• Aggressive or self-injurious behavior

Screening
• Early diagnosis is highly correlated with dramatically better outcomes
• Autism can be reliably diagnosed at 18 months of age
– Checklist for Autism in Toddlers (CHAT)
– Modified Checklist for Autism in Toddlers (M-CHAT)

Diagnosis
•Childhood Autism Rating Scale (CARS)
•Autism Diagnostic Interview—Revised
•Gilliam Autism Rating Scale (GARS)
•Asperger Syndrome Diagnostic Scale (ASDS)
•It is largely based on clinical judgment

Prevalence and Causes
Prevalence
• Recent estimates - Autism occurs in as many as 1 in
150 children (CDC, 2007)
• Boys are affected about 4 times more often than girls
• Autism is the fastest-growing category in special education (autism epidemic)

Prevalence and Causes
Causes
• The cause of autism is unknown
• Controversial theories
–MMR vaccine
–Mercury (thimerosal)
•No evidence of childhood vaccinations causing autism
• There is a clear biological origin of autism in the form of abnormal brain development, structure, and/or neurochemistry
– Genes may be responsible for the abnormality
– Environmental factors may trigger the disorder

Science
 reliable and valid measurements
 pre- post measures
 control/comparison group(s)
 “blind” or independent evaluators
 replication
 published in peer reviewed journals

Pseudoscience
• No scientifically valid evidence
– (no) controlled studies
– (in)consistent findings
– (not) published in peer reviewed journals
• Use “numbers” and graphs
• Ph.D.’s and M.D.s “Institutes”
• www.quackwatch.org

Current unproven or disproven medical interventions
Secretin peptide hormone that stimulates the secretion of digestive fluids, no benefits in 3 controlled studies
Gluten Free/Casein Free Diet food allergies cause or contribute to autism has no sound scientific evidence supporting
Hyperbaric oxygen
The logic for using hyperbaric oxygen treatment for developmental disorders relates to the auto-immune and/or viral theory of these conditions. Encephalitis, in this theory, is thought to be part of developmental disorders. No data on the use of hyperbaric oxygen for developmental disorders

Current unproven or disproven medical interventions
Vitamin B6 and magnesium
Dimethylglycine (DMG) (Vitamin B 15)
AZT (Terovir)
Steroids
Antibiotics
Antifungal medications
Behavioral Optometry
Craniosacral therapy
“The emphasis in Biodynamic Craniosacral Therapy is to help resolve the trapped forces that underlie and govern patterns of disease and fragmentation in both body and mind.
This involves the practitioner "listening through the hands" to the body's subtle rhythms and any patterns of inertia or congestion. “

DIR (Greenspan’s Floortime)
“Floortime is your child’s practice time. Each time you get down on the floor and interact— spontaneously, joyfully, following your child’s interests and motivations—you help him build that link between emotion and behavior, and eventually words, and in doing so move forward on his journey up the developmental ladder”
Sensory Integration is a complex disorder of the brain that affects developing children. Children with SPD misinterpret everyday sensory information, such as touch, sound, and movement.
RDI (Guttstein)
Higashi Method
Music Therapy
AIT (Auditory Integration Training)
Hippotherapy/Dolphin therapy
Occupational Therapy

Found harmful in scientific studies
• Facilitated Communication
• Auditory integration training
• Intravenous immune globulin
• withholding vaccinations

Evidence-Based Treatment
Applied Behavior Analysis is the only treatment approach that has been documented to produce significant gains (comprehensive and long-lasting) for children with ASD
 U.S. Surgeon General’s Report
 New York State Department of Early Intervention Task
Force
 12+ well-designed, peer-reviewed comparison studies
(with over 342 subjects)
 Hundreds of peer-reviewed studies documenting specific ABA procedures

Why Science?
• Basing decisions about interventions mainly on preconceptions, opinions, speculations, subjective impressions, and badly done studies has many risks:
– Wasted money, time, energy
– Exploitation of vulnerable people
– Physical and emotional injuries
– Lost opportunities to make real advances
– Reinforcement and perpetuation of practices that impede progress
• The most tried-and-true way to reduce those risks is to rely on careful scientific evaluation to separate opinions and beliefs from verifiable facts.

Educational Approaches
Applied Behavior Analysis (ABA)
– Discrete Trial Training
– Picture Exchange Communication System (PECS)
– Peer-mediated interventions
– Errorless discrimination learning
– Generalization
– Functional assessment of challenging behavior
– Pivotal response intervention
– Naturalistic language strategies

Educational Approaches (continued)
• Social stories
• Picture activity schedules
Educational Placement Alternatives
• Regular Classroom
• Resource Room

Where do we start?
• Imitation
• Attending to environment
– Visual & auditory
• Eye contact
• Joint Referencing
• Exploratory behavior
• Shared attention

Howard, Sparkman, Cohen, Green, & Stanislaw
(2005)
parental preference most significant factor in placement

Children in the study
• <48 months of age
– Dx
• Autism or PDDNOS
• qualified, independent examiners
– Intervention
• No secondary medical condition
• English primary language
• No IQ “cut off”

 1:6 staffing ratio
 15 - 17 hours per week
 >50% individual or group Speech Tx
 Curriculum
 developmentally appropriate
 language “rich” environments
 typical preschool activities

• 1:1 or 1:2 staffing ratio
•26 - 30 hours per week
•Behavioral consultant
•50% individual or group Speech Tx
•Curriculum
•Discrete trial component
•PECs
•TEACCH
•typical preschool activities

Intensive ABA
 1:1 staffing
 35 hours per week
 errorless learning
 >800 trials/structured opportunities per day
 Joint attention, imitation, and initiation*
 Speech Pathologist consultant

Procedure
– educational placement
– hours and services

Age (mos)
IQ (SS)
Participants at Baseline
Generic EI
(16)
35
Autism (16) Intensive
ABA (29)
39 31
60 54 59
Language (mos) 17
Autism Dx 72
Mother Ed (yrs) 13
15
81
13
14
82
14
28

100
75
Baseline
50
25
60
69
1 Year Followup
54
62
59
90
Generic Autism EIBT