ALTERNATIVE METHODS FOR MANAGEMENT OF ATONIC POSTPARTUM HAEMORRHAGE DR. MURWAN IBRAHIM OMER DGO, MOG, ABOG, FRCOG, FICS Consultant Obstetrician and Gynaecologist Can we change our practice to improve outcome of PPH? When conventional methods fail to control atonic PPH, there are interventions which are being ignored that should be considered before opting for major surgical procedures. Postpartum Haemorrhage Is a leading cause of maternal mortality and morbidity. Too Little (IV fluids, oxytocics, BLOOD, Clotting factors) Too Late (resuscitation - blood replacement, misopristol decision for surgery + to get senior surgeon & anaesthetist involved) PPH Anticipate - high risk cases (e.g. twins, polyhydramnios, prolonged labour, fibroids, APH, infection, past H/O PPH, retained tissue etc.) Prevent - Prophylactic Oxytocics (e.g. Syntometrine, syntocinon, ergometrine, misoprostol) Manage - Promptly - 90% uterine atony - 8% trauma and 2% coagulation disorders FIGO/ ICM STATEMENT ON AMTSL + WHO+ COCHRANE Guidelines by the Scottish Executive Committee of the RCOG COMMUNICATE. RESUSCITATE. MONITOR / INVESTIGATE STOP THE BLEEDING STOP THE BLEEDING Uterine compression IV syntocinon 10 units IV ergometrine 500 mg Syntocinon infusion (30 units in 500 ml) Surgery / Hysterectomy Misoprostol/ Intrauterine pack / Intrauterine balloon / Compression Sutures Misoprostol Synthetic analog of prostaglandin E1 • Shelf life of several years if kept in their packets • Low cost • Can be administered orally, rectally, vaginally and by sublingual route • Being selective for the PGE1 receptors: Hence fewer systemic side-effects Misoprostol could play an important role in saving lives of thousands of women, particularly in low-resource settings A study in Pakistan on the outcome of Utero-vaginal Packaging in Primary Postpartum Hemorrhage on 34 patients 100 80 60 40 20 91.2% 8.8% 0 Success Rate Failure Rate Pelvic infection was seen in 5 cases i.e., 14.7% (but pre- existing risk factors for infection such as prolonged rupture of membranes, obstructed labour and home delivery were present in all these cases) TAMPONADE TEST Therapeutic & Prognostic For severe PPH Oesophageal balloon Stomach balloon The “Tamponade Test” 90 80 70 60 50 40 30 20 10 87.5% 12.5% 0 Success Rate Failure Rate Condous G, Arulkumaran S et.al. Obstetrics & Gynecology. 2003 St George’s Series 18.5% 81.5% Success Rate Failure Rate 27 consecutive cases of Sengstaken – Blakemore Esophageal catheter tamponade Bleeding arrested in 22 cases Tamponade failed in 5 cases. Of them: 4 underwent a subtotal hysterectomy 1 was managed with Haemabate and Misoprostol (concomitant use) Doumouchtsis S, Papageorghiou A, Arulkumaran S. Acta Scand 2008 The Sengstaken-Blakemore oesophageal catheter The main disadvantage is that it is not purpose-designed for PPH. Therefore, it may not easily adapt to the shape of the uterine cavity. “Women are not dying because of diseases we cannot treat. They are dying because societies have yet to make the decision that their lives are worth saving.” Mahmoud Fathalla,MD, PhD, 1997 Uterine balloon tamponade Authors Year Type of study Method No of women Success Rates Goldrath 1983 Case series Foley catheter 20 19/20 (95%) Bakri et al 2001 Case series Silicone Balloon 5 3*/5 (60%) Condous et al 2003 Case series Sengstaken -Blakemore 16 14/16 87.50% Akhter et al 2003 Case series Condom 23 23/23 (100%) Penney et al (Scottish Audit)**** 2003 Audit Balloon 6 5/6 (83.3%) Penney et al (Scottish Audit)**** 2004 Audit Balloon 21 15/21 (71.4%) Seror et al 2005 Case series Sengstaken -Blakemore 17 12/17 (70.6%) St George’s current series 2006 Case series Sengstaken -Blakemore 27 22/27 (81.5%) 135 83.7% Total COMPRESSION SUTURES Quick, safe and effective B-Lynch Modified B-Lynch sutures Combination of sutures Comparison between Original method & its modification B- Lynch brace suture. Modified B-Lynch brace suture. 1. Requires expertise. 1. Easy to perform. 2. Transverse LUS incision required. 3. Time consuming. 2. LUS incision not required. 4. Cervical stenosis. 3. Less time consuming (can be completed in 2-3 min). 4. No cervical stenosis 5. Haematometra 5. No Haematometra formation. formation. 6. Bleeding from LUS due to 6. No bleeding from LUS. multiple bites. B-Lynch or Compression sutures Authors Year Type of study Method B-Lynch et al 1997 Case series B-Lynch Cho et al 2000 Case series Square sutures Pal et al 2003 Case series Smith et al 2003 Penney et al (Scottish Audit) No of women Success Rates 5 5/5 (100%) 23 23/23 (100%) B-Lynch 6 6/6 (100%) Case series B-Lynch 7 6/7 (85.7%) 2003 Audit*** B-Lynch 10 9/10 (90%) Penney at al (Scottish Audit) 2004 Audit*** B-Lynch 19 13/19 (68.4%) Wohlmuth et al 2005 Case series B-Lynch 12 11/12 (91.6%) Pereira et al 2005 Case series Compressive sutures 7 7/7 (100%) Nelson et al 2006 Case series Modified BLynch sutures 5 5/5 (100%) 94 85/94 (90.4 %) Total Conservative Treatment for PPH Method No of Cases Success rates B-Lynch + other Compression sutures 94 90.4% Arterial embolization 218 91% Arterial ligation 264 83.7% Uterine balloon tamponade 135 83.7% Doumouchtsis S, Papageorghiou A, Arulkumaran S. Obstet Gyne Survey 2007 “It is not the strongest of the species that survives, nor the most intelligent, but the one most responding to change.” Charles Darwin No of Deliveries 35000 30000 25000 20000 15000 10000 5000 0 09 20 07 20 05 20 03 20 01 20 99 19 97 19 95 19 93 19 91 19 89 19 87 19 85 19 83 19 81 19 79 19 77 19 75 19 20 09 20 07 20 05 20 03 20 01 19 99 19 97 19 95 19 93 19 91 19 89 19 87 19 85 19 83 19 81 19 79 19 77 19 75 Maternal Mortality Rate 800 700 600 500 400 300 200 100 0 Conclusion When conservative measures fail to control bleeding in post partum haemorrhage, uterovaginal packing, internal uterine tamponade and B-lynch sutures can be used before resorting to hysterectomy. These uterine preserving methods have been used in various countries and have proven to be effective, with minimal maternal morbidity. They are feasible in this country and should be considered by Obstetricians when managing PPH. However, they require training and experience. Emergency Trolley Emergency protocols GENERAL MANAGEMENT Endotracheal tube Laryngoscope Essential drugs Crystalloids, giving sets, haemacel