Pentoxifylline for diabetic kidney
disease
Editorial Group: Cochrane Renal Group
Published Online: 15 FEB 2012
Assessed as up-to-date: 10 JAN 2012
DOI: 10.1002/14651858.CD006800.pub2
Vs 黃智源
2013/04/02
Systematic review: pentoxifylline for the treatment of severe
alcoholic hepatitis.
Parker R, Armstrong MJ, Corbett C, Rowe IA, Houlihan DD.
Aliment Pharmacol Ther. 2013 Mar 13. doi: 10.1111/apt.12279. [Epub ahead of print]
Pentoxifylline and the proteasome inhibitor MG132 induce
apoptosis in human leukemia U937 cells through a decrease in
the expression of Bcl-2 and Bcl-XL and phosphorylation of p65.
Bravo-Cuellar A, Hernández-Flores G, Lerma-Díaz JM, Domínguez-Rodríguez JR, JaveSuárez LF, De Célis-Carrillo R, Aguilar-Lemarroy A, Gómez-Lomeli P, Ortiz-Lazareno PC.
J Biomed Sci. 2013 Feb 28;20(1):13. [Epub ahead of print]
Pentoxifylline for treating venous leg ulcers.
Jull AB, Arroll B, Parag V, Waters J.
Cochrane Database Syst Rev. 2012 Dec 12;12:CD001733. doi:
10.1002/14651858.CD001733.pub3. Review.
Pentoxifylline for intermittent claudication.
Salhiyyah K, Senanayake E, Abdel-Hadi M, Booth A, Michaels JA.
Cochrane Database Syst Rev. 2012 Jan 18;1:CD005262.
doi:10.1002/14651858.CD005262.pub2. Review.
Pentoxifylline for endometriosis.
Lu D, Song H, Li Y, Clarke J, Shi G.
Cochrane Database Syst Rev. 2012 Jan 18;1:CD007677. doi:
10.1002/14651858.CD007677.pub3. Review.
Pentoxifylline for treatment of sepsis and necrotizing
enterocolitis in neonates.
Haque KN, Pammi M.
Cochrane Database Syst Rev. 2011 Oct 5;(10):CD004205. doi:
Preclinical evaluation of the antimetastatic efficacy of
Pentoxifylline on A375 human melanoma cell line.
Kamran MZ, Gude RP.
Biomed Pharmacother. 2012 Dec;66(8):617-26. doi 10.1016/j.biopha.2012.03.006.
Epub 2012 Apr 11.
Pentoxifylline and propentofylline prevent proliferation
and activation of the mammalian target of rapamycin
and mitogen activated protein kinase in cultured spinal
astrocytes.
Norsted Gregory E, Delaney A, Abdelmoaty S, Bas DB, Codeluppi S, Wigerblad G,
Svensson CI.
J Neurosci Res. 2013 Feb;91(2):300-12. doi: 10.1002/jnr.23144. Epub 2012 Nov 27.
Pentoxifylline + cancer -> 54 results,
most related to radiation therapy side effect prevention
Implications for practice
Although pentoxifylline may confer positive effects on kidney
function, albuminuria and proteinuria levels, with a low adverse
event profile. However the poor methodological quality of included
studies, the small number of patients enrolled, and likelihood
of publication bias, provided insufficient evidence to support
the routine use of pentoxifylline for treating patients with type 1
and type 2 DKD.
Filters activated: Clinical Trial, Publication date from 2011/02/01 to 2013/04/01 Clear all
J Diabetes Complications. 2011 Sep-Oct;25(5):314-9. doi: 10.1016/j.jdiacomp.2010.09.003.
Epub 2010 Dec 8.
Pentoxifylline for renoprotection in diabetic nephropathy:
the PREDIAN study. Rationale and basal results.
Navarro-González JF, Muros M, Mora-Fernández C, Herrera H, Meneses B, García J.
Source
Nephrology Service, University Hospital Nuestra Señora de Candelaria, Santa Cruz de
Tenerife, Spain. jnavgon@gobiernodecanarias.org
Thank you for your attention!
The effect of pentoxifylline on proteinuria in
diabetic kidney disease: a meta-analysis.
McCormick BB, Sydor A, Akbari A, Fergusson D, Doucette S, Knoll G.
Am J Kidney Dis.
22. Review.
2008 Sep;52(3):454-63. doi: 10.1053/j.ajkd.2008.01.025. Epub 2008 Apr