Nutrition in the critically-ill Child. Past and Future. Dr. Rainer Paulino Basulto. Msc Dra.Mileidis Pupo Vera. Dr. Willians Rios. I Katima Mulilo. Caprivi Health Directorate. Abstract Enteral feeding is a commonly used form of nutritional supplementation for patients with intestinal failure, both in hospitals and in the community. This article concentrates on the basic principles of enteral feeding, including the physiological effects of feeding into the intestinal tract. It covers the indications for enteral feeding, the different methods of supplying enteral feeds to the gastrointestinal tract, and the potential complications. INTRODUCTION Enteral nutrition consists of providing nutrients via the gastrointestinal tract. Although the term technically refers to nutrition given either by mouth or through a feeding tube, in common usage the term usually refers to tube feeding. In comparison to parenteral nutrition (the provision of nutrients via a venous catheter directly into the bloodstream), enteral nutrition offers several advantages, including lower costs, beneficial effects from utilization of the gastrointestinal tract, and avoidance of the many potential complications of parenteral nutrition. Parental Nutrition Enteral nutrition The mucosal associated lymphoid tissues (MALT) are the specific arm of the immune system which protects the intestinal and extraintestinal external mucosal surfaces through production and secretion of IgA. MALT contains 50% of the body's total immune cell mass and produces more IgA than all other antibodies combined. •Short enteral fasting (3 days), causes gut mucosal atrophy, expressed as a decrease in villus height and crypt depth Normal Atrophy. Mixed infection. Intestinal Failure (stress). Bacterial Translocation. Provide humoral protection as a frontline defense against pathogen borne in aerosols, environment, and the diet. CD4 Hypothesis Critically ill children need enteral feeding for survival, so nutrition plays an important role on the health and development of a critically ill child. Scientific problem COST. Although enteral nutrition therapy is more costly than standard feeds, compared to parenteral nutrition therapy, enteral nutrition is approximately two- to fourfold cheaper on an inpatient or out-patient basis. Based on US Medicare charges, the annual cost of providing enteral nutrition per patient is approximately US$9,605 US$9,327 compared with US$55,193. US$30,596 for parenteral solu-tions.4 In addition, the frequency and cost of hospitalization is higher for patients supported on parenteral nutrition therapy compared with enteral nutrition therapy Cheap Objective. 1.To evaluate those factors that impact on the delivery of enteral tube feeding. Method Prospective studies With transversal curt. In 33 patient with Severe dehydration, Severe malnutrition, Severe Sepsis. Severe Malaria. prematurity Bolus feeding(without pump) Bolus feeding involves the delivery of 10mls to 30mls over a period of 10-30minutes and can be given 46 times a day depending on patients individual feeding regime. Administration can be with a syringe using only the barrel as a funnel to allow the feed to infuse using gravity. Result. Table 1 Age distribution Age Number Percent. 1m - 1y. 9 27.2 1y - 2y 11 33.3 2 - 8 24.2 5 15.1 >5Y 5y Result. Table 2.Distribution according to diagnosis Diagnosis. Number Percent. Severe malnutrition 11 47.8 Severe Sepsis 8 34.7 Acute 7 gastroenteritis with severe dehydration. 17.3 Cerebral malaria 3 9 Prematurity New born 4 12.1 Table.3 Feeding Used. Feeding used number percent Milk 16 69.5 Pediasure and Milk 11 47.8 Resomal 12 52.1 ORS 2 8.6 Juice 18 78.2 Hyper caloric food 24 72.7 Table. 4 Physiological effects of feeding into the intestinal tract Physiological effects Became down 72h After 72 h Fever behavior 28 / 84.8.% 90 80 70 60 50 40 30 20 10 0 Category 1 Category 2 5 / 15.1% Table. 5 Physiological effects of feeding into the intestinal tract. Hemodynamic Parameter. Physiological effects Getting normal 72h After 72 h HR 29 / 87.8% 4 / 12.1% BP 31 / 93.9% 2 / 6% Neurological condition 28/ 84.8% 5/ 15.1 % Table 6.Physiological effects of feeding into the intestinal tract. General condition. General condition Improving 72h After 72 h Good external connection 29 / 87.8% 4 / 12.1% 100 90 80 70 60 50 40 30 20 10 0 Category 1 Category 2 Table 7. Physiological effects of feeding into the intestinal tract. Metabolic control. Metabolic control First 72h After 72 h Hypo glycaemia 1 / 4.3% 0 hyper glycaemia 5 / 21.7% 2 / 8.6% 25 20 15 10 5 0 Category 1 Category 2 Table 8. Physiological effects of feeding into the intestinal tract Physiological effects < 36 c > 36 c Temperature management 2/6% 31 / 93.9% Table 9.Physiological effects of feeding into the intestinal tract. Weigh behavior . Physiological effects Weigh gain first 72h Weigh loss first 72h Weigh behavior 19/57.5% 14/42.4% 20 15 10 5 0 Category 1 Category 2 Table.10.Gastrointestinal complications in critically ill children with enteral tube nutrition Complication. Number percent Abdominal distension 5 15.1% Gastro intestinal bleeding. 0 0 Duodenal perforation 0 0 Tube occlusion. 2 3% Pulmonary aspiration 0 0 Accidental tube removal 3 9% Table 11. Mortality rate. Diagnosis. Number Percent Severe Malnutrition. 1 3.03% Severe Sepsis. 2 6.06% 1 3.03% Acute gastroenteritis with severe dehydration. Cerebral malaria Prematurity Conclusions. Early enteral feedings are feasible, well tolerated, and cost effective in critically ill pediatric patients. WHEN THE ENTERAL ROUTE IS AVAILABLE USE IT ! REFERENCES 1. Harkness L. The history of enteral nutrition therapy: From raw eggs and nasal tubes to purifi ed amino acids and early post-operative jejunal delivery. J Am Diet Assoc 2002;102:399–404. 2. Braga M, Gianotti L, Gentilini O, et al. Early postopera-tive enteral nutrition improves gut oxygenation and reduces costs compared with total parenteral nutrition. Crit Care Med 2001;29:242–8. 3. de Lucas C, Moreno M, Lopez-Herce J, et al. Transpyloric enteral nutrition reduces the complication rate and cost in the critically ill child. J Pediatr Gastroenterol Nutr 2000;30:175–80. 4. Reddy P, Malone M. Cost and outcome analysis of home par-enteral and enteral nutrition. JPEN J Parenter Enteral Nutr 1998;22:302–10. 5. North American Home Parenteral and Enteral Nutrition Patient Registry. 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