The Fast Solution Part 4 of 6 The Aetiology of Obesity Sugars Blood Sugar “Fruit” Sugar Simple carbohydrates - 1-2 sugars Complex carbohydrates – long chains of sugars Table Sugar Are sugars toxic? www.intensivedietarymanagement.com Rising Consumption www.intensivedietarymanagement.com Beverage choices www.intensivedietarymanagement.com Sugar sweetened beverages www.intensivedietarymanagement.com Juice and Childhood Obesity Increased offerings of whole fruits were associated with reduced adiposity gain Faith M S et al. Pediatrics 2006;118:2066-2075 Fruit juice intake predicts increased adiposity gain in children from low-income families www.intensivedietarymanagement.com Sugar Sweetened Beverages 4.5 4.2 4 Weight Gain (kg) 3.5 3 2.5 2 2.04 2.21 1.5 1 0.5 0.15 0 Consistent <1/wk Consistent >1/day <1/wk to >1/day >1/day to <1/wk Nurses Health Study 1991-99 Sugar-Sweetened Beverages, Weight Gain, and Incidence of Type 2 Diabetes in Young and Middle-Aged Women JAMA 2004;292(8):927-934 Schulze MB www.intensivedietarymanagement.com Increased Diabetes Risk of Diabetes 2 1.83 Odds Ratio 1.8 1.6 1.49 1.4 1.2 1 1 1.06 0.8 <1/mo 1-4/mo 2-6/wk >1/d Nurses Health Study 1991-99 Sugar-Sweetened Beverages, Weight Gain, and Incidence of Type 2 Diabetes in Young and Middle-Aged Women JAMA 2004;292(8):927-934 Schulze MB www.intensivedietarymanagement.com Hormonal Obesity Theory Vinegar High Protein Fattening Carbohydrates Fibre Obesity High TG Low HDL Increased Insulin level Hypertension Cortisol Diabetes Fatty Liver Insulin Resistance Time Dependent Metabolic Syndrome www.intensivedietarymanagement.com Carbohydrates raise blood glucose Usual Diet 55% CHO Diet 20% CHO Diet Co-factors Fat Fibre Speed of Digestion Effect of a high-protein, low-carbohydrate diet on blood glucose control in people with type 2 diabetes Diabetes. 2004 Sep;53(9):2375-82 Gannon MC www.intensivedietarymanagement.com Fructose is ‘healthy’ 1983 “We see no reason for diabetics to be denied foods containing sucrose” John Bantle NEJM 1986 “No conclusive evidence (sugars) demonstrates a hazard” FDA 2006 Can substitute sucrose “for other carbohydrates in the meal plan” ADA www.intensivedietarymanagement.com Fructose Fructose Consumption g/day per capita 60 50 40 30 20 Fructose 10 0 Adolescent 1994 Berry AJCN 2007 88;895 72.8 g/day www.intensivedietarymanagement.com High Fructose Corn Syrup Fructose Low glycemic index Cheaper Sweeter than glucose Prevented freezer burn Mixes easily Extends shelf-life Helps breads brown Keeps them soft Found in almost all processed foods especially low fat foods 55% fructose 45% glucose www.intensivedietarymanagement.com Obesity and HFCS www.intensivedietarymanagement.com “High Fructose Corn Syrup “or “High Fructose Table Sugar” Total Sugars Refined Sugar HFCS www.intensivedietarymanagement.com Fructose Metabolism Increased lipogenesis www.intensivedietarymanagement.com Fructose causes insulin resistance Glucose Fructose Insulin Tolerance Tests 25% worse with fructose Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects Am J Clin Nutr. 1980 Feb;33(2):273-8 Beck-Nielsen H www.intensivedietarymanagement.com Endogenous glucose production Fructose causes insulin resistance 6 days of high fructose diet Indication of hepatic insulin resistance Effect of Fructose Overfeeding and Fish Oil Administration on Hepatic De Novo Lipogenesis and Insulin Sensitivity in Healthy Men Diabetes July 2005 54; no. 7 1907-1913, Tappy L www.intensivedietarymanagement.com Fructose causes insulin resistance Glucose Fructose Oral Glucose Tolerance Test www.intensivedietarymanagement.com Fructose causes hyperinsulinemia Glucose Fructose Oral Glucose Tolerance Test www.intensivedietarymanagement.com Fructose causes Insulin Resistance Insulin Resistance! JCI April 20, 2009 Havel et al. www.intensivedietarymanagement.com Hormonal Obesity Theory Vinegar High Protein Fattening Carbohydrates Fibre Obesity High TG Low HDL Increased Insulin level Hypertension Cortisol Diabetes Fatty Liver Insulin Resistance Metabolic Syndrome Fructose www.intensivedietarymanagement.com Fructose Overfeeding and Triglycerides TG increased 79% Effect of Fructose Overfeeding and Fish Oil Administration on Hepatic De Novo Lipogenesis and Insulin Sensitivity in Healthy Men Diabetes July 2005 54; no. 7 1907-1913, Tappy L www.intensivedietarymanagement.com Sugar and Triglycerides NHANES 1999-2006 Mean of 15.8% of consumed calories were added sugars JAMA. 2010;303(15):1490-1497 Vos Caloric Sweetener Consumption and Dyslipidemia Among US Adults www.intensivedietarymanagement.com Sugar and HDL JAMA. 2010;303(15):1490-1497 Vos Caloric Sweetener Consumption and Dyslipidemia Among US Adults www.intensivedietarymanagement.com Fructose and Lipids Fructose Glucose % increase 44.9 27.2 18.2 13.9 2.5 TG 13.3 3.6 LDL 3.5 HDL -2.4 3 apoB sdLDL Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans JCI April 20, 2009 Havel et al. www.intensivedietarymanagement.com Fructose and Blood Pressure NHANES III 2003-2006 4,528 adults who developed hypertension Increased Fructose Associates with Elevated Blood Pressure J Am Soc Nephrol 21: 1543– 1549, 2010 Jalal D www.intensivedietarymanagement.com Reducing SSB lowers blood pressure Tertiles of reduction in sugar sweetened beverages Reducing Consumption of Sugar-Sweetened Beverages Is Associated with Reduced Blood Pressure: A Prospective Study among U.S. Adults Circulation. 2010 June 8; 121(22): 2398–2406 Chen L www.intensivedietarymanagement.com Fructose and Fatty Liver 6x increase in DNL Effect of Fructose Overfeeding and Fish Oil Administration on Hepatic De Novo Lipogenesis and Insulin Sensitivity in Healthy Men Diabetes July 2005 54; no. 7 1907-1913, Tappy L www.intensivedietarymanagement.com SSBs are addictive JAMA. 2004;292(8):927-934 Schulze MB “An increase in liquid carbohydrates leads, perversely, to even greater caloric consumption” www.intensivedietarymanagement.com Hormonal Obesity Theory Vinegar High Protein Fattening Carbohydrates Fibre Obesity High TG Low HDL Increased Insulin level Hypertension Cortisol Diabetes Sugar Fatty Liver Insulin Resistance Metabolic Syndrome Fructose www.intensivedietarymanagement.com Wheat To increase yield, seed head sizes increased www.intensivedietarymanagement.com Dwarf Wheat 99% of wheat grown worldwide www.intensivedietarymanagement.com Broadbalk Wheat Experiment Introduction of high yield Semi dwarf wheat Evidence of decreasing mineral density in wheat grain over the last 160 years J Trace Elem Med Biol. 2008;22(4):315-24 Fan MS Whole Wheat Up to 5% of the wheat kernel removed 70% of the germ Contains most of vitamins, protein and fat www.intensivedietarymanagement.com Whole Grain Processing www.intensivedietarymanagement.com Multi-grain May be 2 refined grains Rice flour Dried potatoes Corn flour www.intensivedietarymanagement.com Speed of Digestion Traditional Stone grinder Modern Flour Mill www.intensivedietarymanagement.com Flour 75% White flour 70% carbohydrate by weight www.intensivedietarymanagement.com Amylopectin Glycemic Index Amylopectin C is the least digestible (Legumes) Amylopectin B (Bananas, potatoes) Amylopectin A (Wheat) Most digestible 80 70 60 50 40 30 20 10 0 Whole Banana Snickers Kidney Wheat Bar Beans Bread Wheat is more efficiently converted to blood sugar than nearly all other carbohydrate foods www.intensivedietarymanagement.com Exorphins Digestion of gluten yields morphine-like compounds ‘exorphins’ Ability to cross blood brain barrier www.intensivedietarymanagement.com COMFORT FOODS Mashed Potatoes and Gravy Ice Cream Apple Pie Mac and Cheese Pancakes Spaghetti and Meatballs Comfort foods (affect mood) often contain wheat and other highly refined carbohydrates www.intensivedietarymanagement.com Problems with Wheat 1. Modern wheat is of lower nutritional value 2. Modern processing removes most of vitamins, fibre and fats 3. Modern milling (as opposed to stone ground) increases speed of digestion 4. High in amylopectin A (highly digestible) 5. May be addictive “Wheat Belly” www.intensivedietarymanagement.com The China Study “In both China Study I and II, wheat is the strongest positive predictor of body weight (r = 0.65, p<0.001) out of any diet variable” rawfoodsos.com www.intensivedietarymanagement.com Asian conundrum Vinegar High Protein Fattening Carbohydrates Fibre Obesity High TG Low HDL Increased Insulin level Hypertension Cortisol Diabetes Wheat Super-carbohydrate Fatty Liver Insulin Resistance Metabolic Syndrome Fructose www.intensivedietarymanagement.com How can we break the cycle? Vinegar High Protein Fattening Carbohydrates Fibre Obesity High TG Low HDL Increased Insulin level Hypertension Cortisol Diabetes Wheat Super-carbohydrate Resistance requires: 1. High Level 2. Persistence Fatty Liver Insulin Resistance Metabolic Syndrome Fructose www.intensivedietarymanagement.com Fasting “Our food should be our medicine. Our medicine should be our food. But to eat when you are sick is to feed your sickness." Hippocrates www.intensivedietarymanagement.com Fasting myths Puts body in “starvation mode” Deprives body of nutrients Weight loss from muscle/ water Causes hypo-glycemia “Yo-yo” diet Overwhelmed with hunger It’s “crazy” www.intensivedietarymanagement.com HUNGER DISAPPEARS “The most astonishing aspect of this study was the ease with which prolonged starvation was tolerated.” E Drenick JAMA 1964 Jan 11; 187:100-105 “A sense of well-being was associated with the fast” JAMA. 1962;181(4):309-312 Duncan GG Effect of an acute fast on energy compensation and feeding behaviour in lean men and women Int J Obesity (2002) 26, 1623 – 1628 Stubbs RJ Increased intake from 2436 to 2914 calories on the day after a fast Over 2 days (2436 x 2) = Fasting Net deficit 4872 2914 1958 calories www.intensivedietarymanagement.com 382 day fast Weight 456 to 180 lbs then remained stable Features of a successful therapeutic fast of 382 days' duration Postgrad Med J(569); Mar 1973 www.intensivedietarymanagement.com Fasting reduces plasma insulin Glucose remains in normal limits but plasma insulin decreases significantly N Engl J Med 1974; 291:1275-1278 15 10 Baseline 5 Fasting 0 Plasma Insulin Fasting: The History, Pathophysiology and Complications West J Med 1982 Nov; 137:379-399 www.intensivedietarymanagement.com Fasting reduces plasma insulin Stable blood sugars Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism Am J Clin Nutr 2005;81:69 –73 Heilbronn LK www.intensivedietarymanagement.com Fasting maintains resting metabolic rate Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism Am J Clin Nutr 2005;81:69–73 Heilbronn LK www.intensivedietarymanagement.com Fasting improves insulin sensitivity Euglycemic clamp Glucose Infusion rate Effect of intermittent fasting and refeeding on insulin action in healthy men J Appl Physiol 99: 2128–2136, 2005 Halberg N www.intensivedietarymanagement.com Fasting increases norephinphrine Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine Am J Clin Nutr 2000;71:1511–5 Zauner C www.intensivedietarymanagement.com Fasting increases Growth Hormone Growth Hormone: Increases availability and utilization of fats for fuel Preserves muscle mass Integrated GH concentration Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man J Clin Invest. 1988 April; 81(4): 968–975 Ho KY www.intensivedietarymanagement.com Intermittent caloric restriction is better Randomized trial 25% caloric reduction The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers Int J Obes (Lond). 2011 May ; 35(5): 714–727 Harvie MN www.intensivedietarymanagement.com Intermittent caloric restriction is better 7.3 6.8 Insulin 6.3 IER CER 5.8 5.3 4.8 Baseline 1 month 3 months 6 months Int J Obes (Lond). 2011 May ; 35(5): 714–727 Harvie MN www.intensivedietarymanagement.com Fasting preserves lean muscle mass Improvements in Coronary Heart Disease Risk Indicators by AlternateDay Fasting Involve Adipose Tissue Modulations Obesity (2010) 18, 2152–2159 Varady KA www.intensivedietarymanagement.com Fasting improves lipids Obesity (2010) 18, 2152–2159 Varady KA www.intensivedietarymanagement.com Fasting breaks the cycle Vinegar High Protein Fattening Carbohydrates Fibre Obesity High TG Low HDL Increased Insulin level Hypertension Cortisol Wheat Super-carbohydrate But Insulin resistance IS diabetes Diabetes Fasting Fatty Liver Insulin Resistance Metabolic Syndrome Fructose www.intensivedietarymanagement.com Diabetes USA American Diabetes Association recommends diabetics eat MORE carbohydrates not less www.intensivedietarymanagement.com Fasting reduces Diabetes P<0.05 The Effect of Short Periods of Caloric Restriction on Weight Loss and Glycemic Control in Type 2 Diabetes Diabetes Care. 1998 Jan;21(1):2-8 Williams KV www.intensivedietarymanagement.com Fasting associated with reduced Diabetes and CAD Usefulness of Routine Periodic Fasting to Lower Risk of Coronary Artery Disease among Patients Undergoing Coronary Angiography Am J Cardiol 2008 Oct 1; 102(7); 814-19 Horne BD www.intensivedietarymanagement.com Fasting associated with less Diabetes and CAD 80 70 Prospective cohort study 60 50 40 Fast 30 Non Fast 20 10 0 Age BMI DM CAD Relation of routine, periodic fasting to risk of diabetes mellitus, and coronary artery disease in patients undergoing coronary angiography Am J Cardiol. 2012 Jun 1;109(11):1558-62 Horne BD www.intensivedietarymanagement.com Food Rationing decreases Diabetes www.intensivedietarymanagement.com Diabetes is a Reversible Disease! Hepatic Glucose Production Changes of insulin sensitivity and beta cell function are reversible Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol Diabetologia 2011 Oct;54(10):2506-14, Lim EL www.intensivedietarymanagement.com Surgical Treatment Roux-En-Y Gastric Bypass Sleeve Gastrectomy Laparoscopic banding >90% cure rates for diabetes www.intensivedietarymanagement.com Surgery cures diabetes Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes N Engl J Med 2012;366:1567-76 Schauer PR Basically surgically enforced fasting regimens www.intensivedietarymanagement.com Fasting vs. Bariatric Surgery 8 7.3 1500 1478 1450 6 Diet 5 4 3 2 1 0 4 Diet + Surgery Daily Glycemia Pre vs Post Weight Loss (kg) 7 1400 1350 1300 1293 1250 1200 Rapid Improvement of Diabetes After Gastric Bypass Surgery: Is It the Diet or Surgery? Diabetes Care. 2013 Mar 25, Lingvay I http://www.ncbi.nlm.nih.gov/pubmed/23530013 www.intensivedietarymanagement.com How to Cure Type 2 Diabetes High Protein Fattening Carbohydrates Wheat Super-carbohydrate Increased Insulin level Fasting Diabetes Bariatric surgery without the surgery – Fasting! Fasting Fructose www.intensivedietarymanagement.com Can We Cure Type 2 Diabetes? No Diabetes – no diabetic nephropathy, no diabetic foot ulcers, diabetic retinopathy, reduced stroke, MI, cancers No Drugs, no surgery, no cost, no long term side effects 6-12 month intensive fasting regime to cure diabetes www.intensivedietarymanagement.com Time to get started… Jason Fung’s Intensive Diabetes Dietary Management (IDDM) Clinic www.intensivedietarymanagement.com