Serbia - Italia Bilateral Cooperation ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF THIO-AVAROL DERIVATIVES 25th and 26th June, 2012 Beograd Pozzuoli - Napoli The Sponges Dysidea avara Dr. Salvatore De Rosa Dirigente di Ricerca National Research Council of Italy Institute of Biomolecular Chemistry CNR-ICB E-mail: sderosa@icb.cnr.it Dr. Giuseppina Tommonaro Ricercatore National Research Council of Italy Institute of Biomolecular Chemistry CNR-ICB E-mail: gtommonaro@icb.cnr.it Mr. Carmine Iodice CollaboratoreTecnico ente di Ricerca National Research Council of Italy Institute of Biomolecular Chemistry CNR-ICB E-mail: ciodice@icb.cnr.it Avarol is a marine sesquiterpene hydroquinone possesing a rearanged drimane skeleton. Avarone is the quinone form of avarol. Avarol Avarone Avarol was found to have anti-inflammatory antipsoriatic antioxidant antitumor antiplatelet analgesic anti-HIV activities. Of particular interest is acetylcholinesterase inhibitory activity of thio-avarol derivatives with a carboxylic group in the molecule, such as avarol-3‘-thiobenzoate avarol-3‘–thiolactate avarol-4‘–thiolactate TLC bioautographic assay (white spot on a purple background) 1 μg Galanthamine was used a positive control. O O N H HO Galanthamine 0.01 μg Dr. Pietro Amodeo I Ricercatore National Research Council of Italy Institute of Biomolecular Chemistry CNR-ICB E-mail: pamodeo@icb.cnr.it Dr. Rosa Maria Vitale Ricercatore National Research Council of Italy Institute of Biomolecular Chemistry CNR-ICB E-mail: rmvitale@icb.cnr.it Binding properties of avarol and its inhibitory derivatives to the enzyme have been characterising by computational approach. This research aims to design new avarol derivatives which better inhibit acetylcholinesterase. Serbia - Italia INSIEME NELLA SCIENZA, INSIEME NELLA VITA