Course Aim
This meeting traditionally brings together
investigators and clinicians with foremost
experience in kidney transplantation, to discuss
topics related to kidney transplant care. Allograft
rejection is a major barrier to transplantation. To
prevent allograft rejection, transplant recipients
require long-term immunosuppression, which is
associated with increased susceptibility to
infection and risk of malignancy, which increase
morbidity and mortality This focus edition of the
Hot Topics in Renal Transplantation addresses
the issue of tolerance in transplantation,
describing tolerance mechanisms, how these
mechanisms can be studied to assess prognosis,
and how they can be overcome to induce tolerance.
Some of the major issues related to transplant
tolerance, including basic mechanisms, and both
HSCT-based and non HSCT-based approaches
be discussed. The interdisciplinarity of workers,
friendly relationships among the participants
makethem a unique opportunity to discuss freely
and in an uninformal context.
CISEF Germana Gaslini
Course Venue
Registration
CISEF G. Gaslini - Badia Benedettina della Castagna
Via Romana della Castagna, 11 A
16148 Genova Quarto - Italy
80 participants will be admitted according to the order
of arrival of the applications.
How to reach the Venue
Completed application should be submitted to the
Scientific Secretariat. The deadline for receipt of
applications is March 31, 2015. Up to 80 participants
will be notified of acceptance by mid April. Cancellations
will be filled from a list of alternates.
Scientific Secretariat
Serena Bagnasco
Department of Pathology, Johns Hopkins University
School of Medicine - Baltimore, USA
Fabrizio Ginevri
Nefrology, Dialysis and Transplantation,
Istituto Giannina Gaslini Ospedale Pediatrico IRCCS
Genoa, Italy
Giacomo Garibotto
Transplant tolerance
Genoa, April 18th 2015
General information
Plane: From the International Airport C. Colombo, shuttle
bus n. 100 (runs every 20 minutes) takes you to Genova
Brignole railway station in 30 minutes.
Train: Participants arriving to Genova by train should bear
in mind that there are two major stations in the city:
Genova-Brignole and Genova-Principe. Not all the trains
- particularly from northern Italy (e.g., Milano) - pass
through Genova-Brignole: therefore, make sure that your
train does indeed stop at Genova-Brignole. From Genova
Brignole railway station, take bus n. 17 and get off in
Corso Europa, in front of the AC Hotel / Coop supermarket.
Car: Motorway exit Genova-Nervi, take Corso Europa
westwards, take the overpass and drive eastwards, pass
Hotel AC and ESSO gas station on the right, after 50 mt.
turn right into Via Romana della Castagna, go straight 80
mt., enter the gate on the right leaving the church on the
left and follow signs for parking.
Hot Topics
in renal transplantation
Free attendance
CME accreditation
856-118806
8 Italian CME credits will be available for medical
doctors (disciplines: surgery, nephrology, pediatrics).
The participant’s CME credit will be dependent upon
completion and return of a content specific quiz to
test the knowledge after the CME activity, and the
satisfaction form.
Official language
The official language of the Congress is English.
No simultaneous translation will be available.
Conference secretariat
and information
Dr.ssa Kristina Cosulich
Centro Internazionale di Studi e Formazione (C.I.S.E.F.)
"Germana Gaslini"
Via Romana della Castagna, 11A
16148 Genova, Italy
ph. +39 010 5636 2882 - fax: +39 010 5636 2885
e.mail: kristinacosulich@cisef.org
www.cisef.org
Division of Nephrology, Dialysis and Transplantation,
Genoa University and IRCCS AOU SanMartino-IST,
Genoa, Italy
Provider Nazionale Accreditato ECM n. 856
Certificazione ISO 9001:2008
The Organizers wish to acknowledge the generous support of
Endorsed requested
IRCCS San Martino - NITP - SIN - SINP - SITO - Renal Pediatric Society
Scientific Program
08.30 Registration
09.00 Introduction
Centro Internazionale
di Studi e Formazione
Germana Gaslini
Direttore: Antonio Infante
Faculty
Serena M. Bagnasco
Department of Pathology, Johns Hopkins University School of Medicine
Baltimore, Maryland, USA
Patrizia Comoli
Ist SESSION
Basic mechanisms and clinical aspects of tolerance
Chairs: A. Nocera (Genoa), F. Frassoni (Genoa)
09.15 Pathways to tolerance of transplanted organs
(G. Grandaliano, Foggia)
09.55 Regulatory T-Cell Therapy in the Induction of Transplant Tolerance
(M. Battaglia H. San Raffaele, Milano)
10.35 Mesenchimal stromal cells to promote tolerance in kidney transplantation
(Giuseppe Remuzzi, Bergamo)
11.15 New strategies to stem cell mobilization
(RM Lemoli, Genova)
11.40 Break
12.00 Chairs: R. Lemoli, F. Frassoni (Genoa)
Tolerance induction by combined Bone Marrow and kidney transplant
(Lode Swinnen JHU, Baltimore, USA)
13.00 Lunch
14.00 IInd SESSION CLINICAL-PATHOLOGICAL DISCUSSION
Kidney graft biopsy findings and clinical implications
for the management of kidney transplant recipient
Chairs: I. Fontana (Genoa), O. Varnier (Genoa)
Discussant: Serena Bagnasco
IIIrd SESSION
Complications in tolerance inducing protocols
Chairs: I. Fontana (Genoa), A. Tagliamacco (Genoa), O. Varnier (Genoa)
15.30 Significance of B cells and plasma cells infiltrates in kidney allograft biopsies
(Serena Bagnasco JHU, Baltimore, USA)
16.10 PTLD: A Changing Clinical Picture
(Lode Swinnen JHU, Baltimore, USA)
16.50 A new approach to antimicrobial therapy: Adoptive cellular immunotherapy
(P. Comoli, Pavia)
17.30 Discussion
18.00 Concluding remarks
Deparment of Hematology and Oncology, Pediatric Research Laboratories,
Fondazione IRCCS, Policlinico San Matteo - Pavia, Italy
Manuela Battaglia
San Raffaele Diabetes Research Institute ( DRI ) - Milan, Italy
Iris Fontana
Kidney Transplant Unit IRCSS IST Azienda Ospedale-Università San Martino
Genoa, Italy
Francesco Frassoni
Stem Cells and Cell Therapy Center, IRCCS Giannina Gaslini - Genoa, Italy
Giacomo Garibotto
Division of Nephrology, Dialysis and Transplantation, Genoa University and IRCCS
AOU SanMartino-IST - - Genoa, Italy
Giuseppe Grandaliano
Head, Nephrology and Trasplant Division - Foggia, Italy
Roberto Massimo Lemoli
Hematology Division, Genoa University and, IRCCS AOU San Martino-IST
Genoa, Italy
Arcangelo Nocera
Transplant Immunology Research Laboratory, Department of Internal Medicine-DIMI,
University of Genova - Genoa, Italy
Giuseppe Remuzzi
RCCS Istituto di Ricerche Farmacologiche “Mario Negri” - Bergamo, Italy
Lode Swinnen
Department of Oncology, Johns Hopkins Hospital Baltimore - Maryland USA
Augusto Tagliamacco
Transplant Immunology Research Laboratory - Di.M.I.,
University of Genova, and IRCSS IST A.O.U. San Martino - Genoa, Italy
Oliviero Varnier
Professor of Microbiology;
Research Director Università degli Studi di Genova, (DISC) - Genoa, Italy