Hello , Everyone !
Medical Immunology
Li Yi
医学免疫学
(李一)
Professor, Director of Ph D 教授、博士生导师
Department of Immunology 免疫学教研室
YILILI19@yahoo.com.cn
Today
 Study of immunology**
 Overview of immunology***
Study of immunology**
（一） 免疫学基本理论部分：20学时。
语言：以英文授课为主、中文总结为辅。
教材：采用国外英文教材为主、中文教材为辅。
授课方式:自讲与讲授两种相结合；
考试方式：50 分（闭卷考试）。
笔试（或口试）中英文必答、中文必答和中英文选答相结合。
（二） 免疫学研究进展部分： 20学时。
语言：以中文授课为主。
授课方式：“以研究专题为中心” 。
考试方式：50 分（开卷考试）。撰写综述。
教学模式确立
双语教学
保留性双语教学
(maintenance bilingual education)
沉浸式双语教学
(immersion program)
过渡式双语教学
(transitional bilingual education)
Approach to study of immunology
I. Study by yourself (Homework)
II. Presentation in class
III. Summary
Groups
I.
9 study groups are needed (4-5 persons/group).
II. Study with your group partners (Homework).
III. Talk by one member of your group in class.
IV.
Summary by teacher.
免疫学基本理论部分： -- 50’
Presentation: 5’
Test:
45’
Presentation Evaluation Criteria
1. Presented or explained content clearly.
10
2. Emphasized important points.
10
3. Summarized or reviewed major points.
10
4. Used graphics or visual aids or other enhancements
to support presentation.
10
5. Used appropriate voice volume and inflection. 10
IMMUNOLOGY
???
Let’s start with
questions
Question-1
Our environment contains a great variety
of infectious microbes, why could we keep
healthy?
Question-2
What should we do before
transplanting blood ---Transfusion ?
Questions - 3
1.
Why do we need to do gene matching before
transplantation ?
2.
Why is it very difficult to find perfect donor for
recipient in transplantation ?
Question-4

Do you have any experience
about allergy?

What is the allergy?
Question-5
1. What is vaccine ?
2. How do vaccines work?
Questions？
Immunology
Answer！
Immunology
Functions
of IS
Immune
System
Pathology
of IS
Applications
Overview of Immunology
Components
of IS
Organs and tissues
Functions
of IS
Antigen (Ag)
Pathology
of IR
Hypersensitivity
Applications
Prevention
Autoimmune disease
Cells
Immune Responses
Immunodeficiency
Tumor
Molecules
Control mechanisms
Transplantation
rejection
* IS: Immune system
IR: Immune response
Diagnosis
Therapy
Functions of Immune System
• Immunological defense
• Immunological homeostasis
• Immunological surveillance
Functions of Immune System -1
• Immunological defense:
The immune system protects us from
attack by microbes and worms.
Functions of Immune System -2
Immunological
homeostasis :
The immune system
could eliminate the
inflammatory or died
self-cells.
Functions of Immune System -3
Immunological surveillance:
The immune system could destroy the
tumor cells and protects us from clinical
tumor formation.
Tumor
cell
Tumor
Tumor
Tumor
cell
cell cell Tumor
Tumor
Tumor cell
cell
cell
Overview of Immunology
Components
of IS
Organs and tissues
Functions
of IS
Antigen (Ag)
Pathology
of IR
Hypersensitivity
Applications
Prevention
Autoimmune disease
Cells
Immune Responses
Immunodeficiency
Tumor
Molecules
Control mechanisms
Transplantation
rejection
* IS: Immune system
IR: Immune response
Diagnosis
Therapy
Immune Responses



Immunologic defense
Immunologic homeostasis
Immunologic surveillance
Organs and tissues
Ag
IR
Cells
Molecules





Hypersensitivity
Immunodeficiency
Autoimmune diseases
Tumor
Transplantation rejection
Components of immune system
 Organs and tissues
 Cells
 Molecules
Components of IS -1
Organs and Tissues of Immune System
— Primary lymphoid organs
• Bone Marrow
• Thymus
— Secondary lymphoid organs
• Lymph nodes
• Spleen
• Mucosa-associated lymphoid tissues (MALT)
Components of IS -2
Cells of Immune System
—
—
—
Mononuclear phagocyte system
Granulocytes
Lymphocytes
Neutrophils
Basophils
Eosinophils
T lymphocyte
B lymphocyte
NK (Natural killer cells)
Monocyte
Macrophage
Dendritic Cells
Classes of T cells
TH: T help cells
TH1
TH2
TC: T cytotoxic cells, CTL
Cells of Immune System
Phagocytes:
Cells of mononuclear phagocyte system
Neutrophils (Polymorphonuclear neutrophils, PMN)
Auxiliary cells
Basophiles (mast cells)
Cytotoxic cells
Tc (CTLs)
NK cells
Eosinophils
Components of IS -3
Molecules of Immune System
— Antibody (Ab)
— Complement (C)
— Cytokines (CK)
— Major Histocompatibility Complex (MHC)
Overview of Immunology
Components
of IS
Organs and tissues
Functions
of IS
Antigen (Ag)
Pathology
of IR
Hypersensitivity
Applications
Prevention
Autoimmune disease
Cells
Immune Responses
Immunodeficiency
Tumor
Molecules
Control mechanisms
Transplantation
rejection
* IS: Immune system
IR: Immune response
Diagnosis
Therapy
Functions of Immune System
Antigen (Ag)
Immune Responses (IR)
Control mechanisms
See:
Immune Response (IR)
Target
cells
MHC
CK
Th1
CKs
Tc
NK
Ag
DCs
MHC
CK
Th2
CKs
Ab
B
PMN
Complement
Types of Immune Response
 Innate immunity (Natural immunity)
 Adaptive immunity (Acquired immunity)
Innate and Adaptive Immunity
Innate immunity
Adaptive immunity
Cells
Mq/DCs
Granulocytes
NK cells
T and B cells
Molecules
Cytokines
Complement
Antibodies
Characteristics
Responds rapidly
No specificity
No memory
Slow to start
Highly specificity
Memory
Overview of Immunology
Components
of IS
Functions
of IS
Organs and tissues
Cells
Antigen (Ag)
Pathology
of IR

Hypersensitivity

Autoimmune
Molecules
－ Antibodies
－ Complement
－ Cytokines
disease
Immune Responses
Control mechanisms
－ MHC
* IS: Immune system
IR: Immune response

Immunodeficiency

Tumor

Transplantation
rejection
Applications
Prevention
Diagnosis
Therapy
HYPERSENSITIVITY
The immune system “overreacts ”
to antigen
function disorder or
tissue damage
Types of hypersensitivity
Type I:
Allergy or immediate
Type II:
Cytotoxic
Type III:
Immune complex
Type IV:
Cell mediated or delayed
Different ??
Mechanisms !!
Autoimmune disease (AD)
CKs
T
Self
Mq
B
Ab
Complement
Self-Ag
Immune
system
Immune
response
Tissue
Damage
Immune Response (IR)
Target
cells
MHC
CK
Tumor
cell
Th1
CKs
Tc
NK
DCs
MHC
CK
Th2
CKs
Ab
B
PMN
Complement
Tumor escape from surveillance
Immune
system
Tumor
cell
Tumor
Tumor
cell
cell
Tumor
Tumor Tumor
cell cell
cell
TumorTumor
cell cell
Clinical tumor
Why???
Rejection mechanisms
Immune
System
Grafts
Ag
Immune
response
Recipient
Grafts rejection
Overview of Immunology
Components
of IS
Functions
of IS
Organs and tissues
Cells
Antigen (Ag)
Immune Responses
Prevention
Immunodeficiency
Diagnosis
Tumor
－ Complement
－ Cytokines
Hypersensitivity
Applications
Autoimmune disease
Molecules
－ Antibodies
Pathology
of IR
Control mechanisms
－ MHC
* IS: Immune system
IR: Immune response
Transplantation
rejection
Therapy
Study of immunology**
（一） 免疫学基本理论部分：20学时。
语言：以英文授课为主、中文总结为辅。
教材：采用国外英文教材为主、中文教材为辅。
授课方式:自讲与讲授两种相结合；
考试方式：50 分（闭卷考试）。
笔试（或口试）中英文必答、中文必答和中英文选答相结合。
（二） 免疫学研究进展部分： 20学时。
语言：以中文授课为主。
授课方式：“以研究专题为中心” 。
考试方式：50 分（开卷考试）。撰写综述。
免疫学基本理论部分：20学时
Components of IS
Organs and tissues [1]
Functions of IS
Antigen (Ag) [7]
Cells [2]
Molecules
Immune Responses [8]
－ Antibodies [3]
－ Complement [4]
－ Cytokines [5]
－ MHC [6]
* IS: Immune system
IR: Immune response
Control mechanisms [9]