THE AUSTRALIA AND NEW ZEALAND
CARDIOTHORACIC ORGAN TRANSPLANT REGISTRY
EIGHTEENTH ANNUAL REPORT
1984 – 2013
ANZCOTR 2013
NUMBER OF ALL TRANSPLANT
TYPES BY YEAR 1984 - 2013
200
150
100
50
0
84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 0 1 2
HEARTS
HEART-LUNG
SINGLE LUNG
3 4 5
6 7 8 9 10 11 12 13
B-L LUNG
ANZCOTR 2013
NUMBER OF ALL TRANSPLANTS* 1984 - 2013
YEAR
1984
1985
1986
1987
1988
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
HEART HEART-LUNG SINGLE LUNG BILATERAL LUNG
14
0
0
0
22
0
0
0
34
1
0
0
30
1
0
0
56
2
0
0
93
14
0
0
103
12
5
0
103
19
18
0
115
18
27
3
114
13
24
33
104
13
26
44
108
13
28
43
103
7
32
42
105
4
43
43
82
4
38
50
76
2
27
47
70
2
28
73
82
1
29
55
82
9
29
70
89
5
20
68
Grand Total all Transplants
78
6
13
91
89
6
10
79
80
6
17
88
68
6
8
78
90
5
12
112
71
2
13
115
76
3
10
123
76
2
12
158
85
4
4
153
86
2
5
181
2384
182
478
1749
4793
*Includes domino, heterotopic and retransplants
ANZCOTR 2013
ALL HEART TRANSPLANTS BY HOSPITAL 1984 - 2013
1984
1985
1986
1987
1988
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
Totals
St Vincents
14
22
34
28
49
50
47
41
36
39
44
41
35
35
26
19
20
17
19
14
28
26
19
18
27
19
27
24
25
25
868
The Alfred Royal Perth
30
38
33
37
35
25
25
24
28
23
25
22
30
24
24
23
22
22
21
28
18
23
17
15
23
635
7
4
5
9
8
6
7
6
11
7
12
7
5
13
7
6
9
13
7
149
Auckland
2
5
8
6
5
11
8
10
7
13
14
10
10
13
15
8
22
4
13
8
9
8
11
11
11
12
9
263
Prince Charles Royal Childrens Year Totals
14
22
34
30
2
56
5
93
8
4
103
20
4
103
22
9
115
28
4
114
21
4
104
20
8
108
24
3
103
21
2
105
10
4
82
11
3
76
9
0
70
8
5
82
17
8
82
16
2
89
14
2
78
13
3
89
16
8
80
13
2
68
8
6
90
10
6
71
3
6
76
10
5
76
13
7
85
13
9
86
348
121
2384
HEART LUNG TRANSPLANTS BY HOSPITAL 1986 - 2013
1986
1987
1988
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
Total
St Vincents The Alfred Royal Perth
1
0
0
1
0
0
1
0
0
11
0
0
6
6
0
5
13
0
8
10
0
6
5
0
6
6
0
9
4
0
4
3
0
3
1
0
4
0
0
0
1
0
2
0
0
0
1
0
2
4
0
1
2
0
3
0
0
1
0
1
1
3
0
3
0
1
1
3
1
0
0
0
0
1
2
0
1
0
3
0
0
1
0
0
83
64
5
Prince Charles 2005 figure includes one retransplant
Auckland
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
Prince Charles Royal Childrens Year Totals
0
0
1
0
0
1
0
1
2
0
3
14
0
0
12
0
1
19
0
0
18
0
2
13
0
1
13
0
0
13
0
0
7
0
0
4
0
0
4
1
0
2
0
0
2
0
0
1
3
0
9
2
0
5
3
0
6
4
0
6
2
0
6
2
0
6
0
0
5
2
0
2
0
0
3
1
0
2
1
0
4
1
0
2
22
8
182
ANZCOTR 2013
SINGLE LUNG TRANSPLANTS BY HOSPITAL 1990 - 2013
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
Totals
St Vincents The Alfred Royal Perth
3
2
0
14
4
0
19
8
0
14
9
0
10
14
0
10
17
0
9
18
0
16
21
0
10
25
0
12
13
0
7
16
0
5
21
0
3
20
0
4
10
0
0
10
1
3
2
4
2
9
3
2
6
0
3
4
4
2
7
2
1
7
0
2
8
2
0
2
2
1
3
1
152
256
19
Auckland
0
0
0
1
2
1
2
3
3
1
3
3
3
4
0
0
1
0
0
1
0
0
0
0
28
Prince Charles
0
0
0
0
0
0
3
3
0
1
2
0
3
2
2
1
2
0
1
1
2
0
0
0
23
Royal Childrens Year Totals
0
5
0
18
0
27
0
24
0
26
0
28
0
32
0
43
0
38
0
27
0
28
0
29
0
29
0
20
0
13
0
10
0
17
0
8
0
12
0
13
0
10
0
12
0
4
0
5
0
478
ANZCOTR 2013
BILATERAL LUNG TRANSPLANTS BY HOSPITAL
1992 - 2013
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
Total
St Vincents The Alfred
2
1
14
19
21
22
18
23
23
12
13
20
17
16
13
20
29
25
28
18
28
25
28
25
31
32
28
27
32
35
25
29
40
40
38
49
40
54
43
70
47
57
45
68
603
687
Royal Perth
0
0
0
0
0
0
0
0
0
0
0
0
0
2
4
6
6
4
7
12
12
11
64
Auckland
0
0
1
2
6
1
2
6
9
8
5
10
9
8
9
9
12
7
9
10
12
19
154
Prince Charles Royal Childrens Year Totals
0
0
3
0
0
33
0
0
44
0
0
43
0
1
42
8
1
43
13
2
50
7
1
47
10
0
73
1
0
55
12
0
70
5
0
68
19
0
91
14
0
79
8
0
88
9
0
78
14
0
112
17
0
115
13
0
123
23
0
158
25
0
153
38
0
181
236
5
1749
Includes retransplants
ANZCOTR 2013
COMBINED WAITING LIST ACTIVITY 2013
HEARTS TOTAL
LUNGS TOTAL
Active as at 1 January 2013
78
107
New Additions during 2013
105
227
W1 - Transplant Performed
86
188
W2 - Patients condition Improved
5
2
W3 - Too ill, new dev of contraindications etc
12
10
W4 - Patient declined
1
1
W5 - Transferred to another interstate list
1
0
W6 - Died waiting
15
14
0
1
From on hold to Active Jan 2013
Removals from Waiting List (Permanent)
W7-Removed - unspecified
TOTAL at Year end - (Active) 31 December 2013
58
108
Total at month end inactive - (On HOLD)
9
10
*Contains complete calendar year activity from all Registry Participant Centres. nb lungs column includes heart/lung procedures
ANZCOTR 2013
PRE TRANSPLANT DIAGNOSIS
HEART 1984 - 2013
Retransplant 1%
Other 13%
ISCHAEMIC HEART DISEASE 34%
Peripartum CM 1%
Familial CM 2%
Congenital HD 6%
Viral CM /
Myocarditis 3%
IDIOPATHIC DILATED
CARDIOMYOPATHY 40%
ANZCOTR 2013
PRE TRANSPLANT DIAGNOSIS
1984 - 2013
n = 2384
Pre Transplant Diagnosis (Hearts)
Idiopathic Cardiomyopathy (IDCM)
Ischaemic Heart Disease (IHD)
Other (eg. Valve disease, adriamycin toxicity,trauma)
Congenital Heart Disease
Viral Cardiomyopathy/Myocarditis
Familial Cardiomyopathy
Peripartum Cardiomyopathy
Retransplantation
Total
Number
962
801
323
133
63
55
24
23
2384
%
40%
34%
13%
6%
3%
2%
1%
1%
100%
ANZCOTR 2013
PRE-TRANSPLANT STATUS
HEARTS 1996 -2013
ANZCOTR 2013
PRE-TRANSPLANT STATUS
HEARTS 1993 - 2013
STATUS - Year
96
97 98 99
0
1
2
3
4
5
6
7
8
9
10 11 12
13
n= 103 105 82 75 70 80 82 88 76 89 79 68 90 71 76 76 84
86
NYHA III %
70
55 57 60 61 64 50 67 50 43 34 44 59 38 60 28 49
NYHA IV %
17
24 26 20 29 20 32 16 27 27 28 21
8
21
7
8
13
7
Inotropic support %
9
13 12 15
6
10 12 11
5
3
11 10
8
9
4
9
2
17
Intra-aortic Balloon
Pump %
1
1
1
1
0
0
2
1
5
1
0
0
0
0
1
0
1
Ventricular Assist
Device %
3
7
4
4
4
6
4
5
13 26 27 25 25 32 28 29 35
40
0
0
0
0
0
0
0
0
0
Total Artificial Heart %
0
0
0
0
0
0
1
1
1
35
0
ANZCOTR 2013
DONOR / RECIPIENT STATE OF ORIGIN
HEARTS
1984 - 2013
800
700
600
Number
500
400
300
200
100
0
ACT
NT
NSW QLD VIC
Recipients 1984-2013
SA
WA TAS
NZ
Donors 1984-2013
ANZCOTR 2013
DONOR / RECIPIENT STATE OF
ORIGIN HEARTS 1984 - 2013
Location
Recipients 84-13
%
Donors 84 - 13
%
Recipients 2013
%
Donors 2013
%
ACT
NT
NSW
QLD
VIC
SA
WA
TAS
NZ
42
5
710
387
594
104
184
58
287
1.8
0.2
29.9
16.3
25.1
4.4
7.8
2.4
12.1
49
20
613
453
507
214
162
36
290
2.1
0.9
26.2
19.3
21.6
9.1
6.9
1.5
12.4
2
0
22
16
24
1
7
3
9
2
0
26
19
29
1
8
4
11
1
1
21
15
16
10
11
0
9
1.2
1.2
25.0
17.9
19.0
11.9
13.1
0.0
10.7
TOTALS
2371
100.0
2344
100.0
84
100
84
100.0
ANZCOTR 2013
Mean Waiting Time to Transplant
HEARTS 1984 - 2013
250
200
DAYS
150
100
50
0
84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 0
YEAR
1
2
3
4
5
6
7
8
9 10 11 12 13
Mean Waiting Time in days
ANZCOTR 2013
WAITING DAYS TO HEART TRANSPLANT 1984-2013
Year
1984
1985
1986
1987
1988
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
n=
14
19
32
30
56
93
103
103
115
114
104
108
103
105
82
75
70
80
82
88
76
89
79
63
89
68
74
76
84
84
mean
44
46
67
61
80
86
99
103
87
116
192
203
171
228
185
236
196
177
148
143
134
159
150
163
171
147
180
171
202
225
std dev + 77
54
76
80
102
87
154
126
119
127
219
236
200
265
219
260
227
212
219
162
176
169
155
180
174
132
232
165
213
298
median
10
19
37
40
33
61
35
57
51
78
128
107
92
127
117
133
120
88
64
91
67
113
102
125
127
103
97
115
139
102
min-max
4-295
3-209
3-295
3-424
1-400
1-445
1-842
1-633
1-790
1-626
1-1392
3-1684
2-1144
1-2577
1-1260
1-2411
1-1431
1-2048
1-1502
1-782
1-908
2-792
2-764
2-974
1-976
5-565
1-1189
1-586
2-1181
0-1668
ANZCOTR 2013
Mean Recipient Age at Transplant
HEARTS 1984 -2013
50
40
Age(yrs)
30
20
10
0
84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 0 1 2 3 4 5 6 7 8 9 10 11 12 13
Year
ANZCOTR 2013
RECIPIENT AGE AT HEART TRANSPLANT YEARS 1984 - 2013
year
1984
1985
1986
1987
1988
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
n
14
19
32
30
56
93
103
103
115
114
104
108
103
105
82
75
70
80
82
88
76
89
79
66
89
68
74
76
84
84
mean
33
39
40
41
41
42
43
47
45
46
47
46
48
46
46
47
49
45
45
45
47
48
43
46
46
45
47
45
42
42
std dev + 15
13
13
12
14
14
15
14
15
14
13
16
13
14
15
15
13
15
18
15
15
14
17
16
17
17
16
17
16
18
median
39
38
43
46
45
46
47
52
51
51
50
50
53
50
51
53
53
49
52
47
52
52
49
49
50
48
52
48
47
48
min-max
11-51
10-54
11-57
13-56
4-63
1-65
6-65
1-64
4-66
6-65
1-66
2-68
10-64
9-66
1-64
2-67
12-66
2-64
7-70
1-67
9-66
5-65
3-67
5-71
6-67
1-69
5-70
5-72
1-67
1-70
ANZCOTR 2013
Hearts Mean Donor Age 1984 - 2013
40
35
30
Age in
years
25
20
15
10
5
0
84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 0 1 2 3 4 5 6 7 8 9 10 11 12 13
Year
ANZCOTR 2013
DONOR AGE HEARTS - YEARS 1984-2013
year
1984
1985
1986
1987
1988
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
n
14
19
32
30
56
93
103
103
115
114
104
108
103
105
82
75
70
80
82
88
76
89
79
66
89
68
74
76
84
84
mean
24
24
26
25
25
28
30
30
30
34
34
32
33
35
31
34
33
33
30
35
33
37
31
34
37
33
38
34
34
33
std dev +8
7
7
7
8
11
11
12
12
13
14
14
12
13
13
16
13
14
15
14
14
14
14
15
13
14
12
14
14
15
median
23
21
25
24
23
26
28
28
28
32
31
33
33
35
30
32
33
33
25
36
31
39
29
35
40
34
39
33
34
34
min-max
13-41
15-43
16-39
14-41
12-44
1-50
9-52
5-58
1-56
8-61
1-66
2-59
1-57
12-58
1-62
1-64
5-57
6-58
2-60
8-62
7-59
9-61
5-59
10-59
2-61
5-62
6-60
5-58
4-58
1-57
ANZCOTR 2013
HEARTS - Mean Ischaemic Time
1984 - 2013
300
250
Minutes
200
150
100
50
0
84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 0
1 2
3
4 5
6
7 8
9 10 11 12 13
Year
ANZCOTR 2013
MEAN HEART ISCHAEMIC TIME 1984-2013
MINUTES
ANZCOTR 2013
ACTUARIAL SURVIVAL - HEART
TRANSPLANT 1984 - 2013
YEAR
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
n*
2364
2004
1870
1762
1653
1549
1423
1319
1206
1079
978
874
776
692
615
536
456
387
329
280
223
171
124
93
68
37
20
14
6
3
%
100.0
86.9
84.5
82.4
80.2
78.0
75.0
72.1
69.3
65.8
63.0
60.3
57.0
55.0
51.9
48.4
44.7
42.1
39.3
37.2
35.7
33.1
30.3
28.7
27.3
24.8
23.1
21.8
19.7
15.8
n* = Number alive at
start of year
ANZCOTR 2013
ACTUARIAL SURVIVAL - HEART
TRANSPLANT 1984 - 2013
Percent
Survival
100
90
80
70
60
50
40
30
20
10
0
0
1
2
3
4
5
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
YEAR
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ANZCOTR 2013
ACTUARIAL SURVIVAL – ORTHOTOPIC v HETEROTOPIC
v DOMINO TRANSPLANTS 1984 - 2013
Orthotopic
YEAR
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
n
2364
2004
1870
1762
1653
1549
1423
1319
1206
1079
978
874
776
692
615
536
456
387
329
280
223
171
124
93
68
37
20
14
6
3
%
100.0
86.9
84.5
82.4
80.2
78.0
75.0
72.1
69.3
65.8
63.0
60.3
57.0
55.0
51.9
48.4
44.7
42.1
39.3
37.2
35.7
33.1
30.3
28.7
27.3
24.8
23.1
21.8
19.7
15.8
Heterotopic
n
%
31
100.0
22
71.0
19
61.3
18
58.1
18
58.1
17
54.8
15
54.8
13
54.8
11
46.4
10
42.2
9
42.2
8
42.2
7
42.2
4
35.2
2
35.2
1
17.6
Domino
n
36
29
28
27
22
21
19
18
18
15
15
15
13
13
13
13
12
12
10
8
6
5
4
%
100.0
80.6
80.6
77.7
63.3
63.3
57.3
54.3
54.3
48.1
48.1
48.1
41.6
41.6
41.6
41.6
38.4
38.4
35.1
28.1
28.1
23.4
23.4
ANZCOTR 2013
Actuarial Survival Orthotopic v Heterotopic v
Domino Hearts 1984 - 2013
100
80
60
Percent
Survival
40
20
0
0
1
2
3
4
5
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
Orthotopic
Heterotopic
Domino
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ANZCOTR 2013
ACTUARIAL SURVIVAL ALL HEARTS
PERIOD COMPARISON 1984 – 2013
100
p<0.001
80
Percent
Survival
60
40
20
0
0
1
2
3
4
5
6
7
8
9
10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
1984-89
1990-99
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
2000-09
2010-13
ANZCOTR 2013
ACTUARIAL SURVIVAL HEARTS
PERIOD COMPARISON 1984 - 2013
1984-1989
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
n*
244
213
202
198
196
192
185
176
168
158
145
139
132
127
117
107
97
94
87
84
81
76
70
66
63
38
21
14
6
3
1
1990-1999
%
100.0
87.3
82.8
81.1
80.3
78.7
75.8
72.1
68.9
64.8
59.4
57.0
54.1
52.0
48.0
43.9
39.8
38.5
35.7
34.4
33.2
31.1
28.7
27.0
25.8
23.4
21.9
20.6
18.7
14.9
14.9
*N = NUMBER ALIVE AT START OF YEAR
n*
1012
871
847
819
789
762
725
688
654
621
595
566
532
514
487
429
359
297
242
196
144
95
54
27
5
2000-2009
%
100.0
86.1
83.7
80.9
78.0
75.3
71.6
68.0
64.6
61.4
58.8
55.9
52.9
50.8
48.1
45.1
41.9
39.2
36.6
34.4
33.0
30.3
27.6
26.3
24.7
n*
790
695
678
665
652
597
514
456
384
301
239
171
115
51
12
2010-2013
%
100.0
88.0
85.8
84.2
82.5
80.8
78.7
77.4
75.9
72.7
70.8
69.1
66.3
63.9
61.9
n*
318
227
144
84
16
%
100.0
87.0
85.1
84.4
81.1
ANZCOTR 2013
ACTUARIAL SURVIVAL PRE
TRANSPLANT DIAGNOSIS 1984 - 2013
100
80
IDCM v IHD
p<0.005
IHD v Others
p<0.005
60
Percent
40
20
0
0
1
2
3
4
5
6
7
8
9
10
11
12
13
IHD
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
14
15
IDCM
16
17
18
19
20
21
22
23
24
25
26
27
28
Others
ANZCOTR 2013
29
ACTUARIAL SURVIVAL PRE TRANSPLANT
DIAGNOSIS HEARTS 1984 – 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
IHD
n
%
801
669
634
610
578
545
503
466
431
383
349
316
268
243
210
181
154
126
106
82
68
51
32
24
18
6
2
100.0
84.4
81.4
79.7
77.3
74.8
71.1
67.6
64.5
60.0
56.8
54.2
49.5
47.8
45.0
42.1
37.8
33.9
31.7
28.2
26.7
24.6
21.2
18.4
17.6
14.9
14.9
1
1
7.4
7.4
IDCM
n
%
970
835
773
721
668
631
584
543
487
448
408
369
341
303
278
243
209
186
160
140
110
84
65
51
39
22
13
9
100.0
89.1
86.4
84.0
81.1
79.3
76.6
74.3
70.6
69.2
66.8
64.7
62.4
60.5
57.3
53.4
50.9
49.1
46.9
45.1
43.3
40.3
37.2
36.5
34.2
31.0
29.2
29.2
3
1
24.7
14.8
Others
n
%
595
502
464
435
408
375
337
311
288
249
222
191
170
146
128
112
93
79
63
58
47
36
27
18
11
10
6
4
2
100.0
86.9
85.6
83.4
82.4
80.3
77.7
74.8
74.1
69.0
65.9
62.2
59.5
56.9
53.7
49.8
45.1
43.6
38.4
38.4
37.7
35.0
34.0
32.5
32.5
32.5
28.7
28.7
28.7
2
28.7
ANZCOTR 2013
ACTUARIAL SURVIVAL PRE-TRANSPLANT
STATUS HEARTS 1984 - 2013
100
80
p=ns
60
40
Percent
Survival
20
0
0
1
2
3
4
5
6
NYHA III
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
NYHA IV
INOTROPES
IABP
All VAD
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ANZCOTR 2013
ACTUARIAL SURVIVAL PRE-TRANSPLANT
STATUS HEARTS 1984 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
NYHA III
n=
1157
1004
959
909
849
799
733
680
622
570
528
470
418
365
321
270
231
197
161
130
92
68
44
35
20
11
7
4
%
100.0
87.5
85.4
82.8
80.2
77.8
74.8
72.2
68.6
65.9
63.3
60.6
58.2
56.1
52.8
49.0
45.3
43.0
40.0
37.6
36.2
34.1
32.3
30.7
28.5
23.5
23.5
19.6
NYHA IV
n=
578
495
463
450
437
420
402
377
346
308
277
253
225
208
187
166
140
120
105
92
82
65
51
37
32
20
9
6
4
2
INOTROPES
%
100.0
86.4
83.4
82.0
80.9
79.4
77.3
73.8
72.0
67.7
64.1
61.7
57.3
55.4
52.2
48.5
44.8
41.5
39.0
36.7
34.6
31.5
28.4
26.5
26.5
25.5
22.2
22.2
22.2
15.9
n=
264
225
214
205
197
187
171
156
145
133
123
112
97
86
79
73
60
53
43
39
35
28
21
15
12
5
3
2
%
100.0
88.4
86.4
84.4
82.7
80.6
75.4
71.8
69.4
65.1
63.1
61.0
56.5
54.1
51.5
49.5
45.2
42.9
39.5
37.6
37.6
35.3
31.2
31.2
26.9
26.9
26.9
26.9
IABP
n=
51
43
43
41
38
37
35
35
34
33
30
25
23
21
20
18
17
16
15
15
14
10
7
6
4
2
2
2
2
1
%
100.0
84.3
84.3
82.3
76.3
74.3
70.3
70.3
68.3
66.3
62.2
55.8
53.5
51.1
48.7
43.8
43.8
41.2
38.6
38.6
36.1
33.2
29.5
25.3
25.3
18.1
18.1
18.1
18.1
18.1
All VAD
n=
274
218
181
156
128
105
82
70
55
33
21
18
14
11
8
7
6
5
3
3
2
2
%
100.0
87.8
83.5
82.0
78.6
75.3
71.4
69.5
67.4
61.5
57.1
54.2
47.9
47.9
47.9
47.9
41.0
41.0
41.0
41.0
41.0
41.0
ANZCOTR 2013
ACTUARIAL SURVIVAL RECIPIENT
AGE BY GENDER HEARTS 1984 - 2013
MALES 0-39
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
n=
451
388
356
332
316
298
278
261
234
207
188
171
154
141
131
121
105
91
77
72
63
47
37
30
22
14
11
7
3
2
FEMALES 0 - 39
%
100.0
88.3
86.0
83.0
82.0
79.9
78.0
76.6
73.2
69.3
67.3
65.4
62.7
62.2
60.4
59.5
55.9
54.2
50.5
49.1
48.4
45.0
44.0
42.7
41.1
36.7
36.7
36.7
36.7
24.5
*N= NUMBER ALIVE AT START OF YEAR
n=
232
192
185
168
156
145
130
118
107
95
89
77
71
61
56
51
46
40
34
33
27
24
17
16
10
6
4
3
1
1
MALES >39
%
100.0
86.4
85.0
79.4
77.0
76.0
72.7
69.3
69.3
66.0
63.2
58.7
57.2
53.0
51.2
48.4
47.4
46.4
43.9
43.9
43.9
42.2
40.2
40.2
40.2
40.2
32.9
32.9
32.9
32.9
n=
1390
1178
1100
1050
983
924
855
793
725
659
600
538
475
423
370
312
261
223
184
150
114
89
58
42
31
15
5
4
2
FEMALES > 39
%
100.0
86.6
83.9
82.3
79.4
76.9
73.5
70.4
67.0
63.7
60.9
58.2
54.7
52.5
49.1
44.5
40.5
37.3
34.5
31.9
29.8
27.3
23.8
22.9
21.6
19.8
19.8
15.9
11.3
n=
296
249
232
217
199
185
166
150
140
120
104
93
79
68
60
52
44
39
34
26
22
14
12
6
5
3
1
%
100.0
86.6
84.2
83.8
83.4
81.7
78.5
75.1
74.0
70.7
66.4
63.8
59.5
57.9
53.5
51.6
47.5
46.4
45.1
42.2
42.2
39.9
37.0
26.4
22.0
17.1
10.3
ANZCOTR 2013
ACTUARIAL SURVIVAL BY RECIPIENT
AGE AND GENDER HEARTS 1984 - 2013
100
80
Percent
Survival
MALES 0-39 yrsv MALES>39yrs
p<0.005
MALES>39yrs v FEMALES>39yrs
p <0.05
60
40
20
0
0
1
2
3
4
5
6
MALES 0-39
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
FEMALES 0-39
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
MALES >39
FEMALES > 39
ANZCOTR 2013
ACTUARIAL SURVIVAL DONOR
AGE HEARTS 1984 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
*
0 - 16
n=
215
198
174
163
157
149
142
134
121
112
105
96
84
75
69
64
53
47
43
38
35
31
24
20
13
8
6
3
2
2
1
%
100.0
90.1
88.6
85.5
84.0
82.3
79.5
76.7
73.2
68.9
67.0
65.7
64.3
62.7
60.1
58.3
54.5
51.3
50.2
47.8
47.8
47.8
44.4
42.4
39.9
39.9
39.9
39.9
39.9
39.9
39.9
17 - 39
n=
1347
1176
1111
1058
996
936
867
814
753
683
618
550
493
441
394
345
295
258
222
195
158
118
85
64
49
29
15
11
4
1
%
100.0
89.0
87.0
84.9
83.0
80.7
77.7
75.2
73.1
69.6
66.1
62.4
58.8
56.3
53.0
49.7
45.5
43.3
40.7
39.1
37.6
34.0
30.8
28.8
27.3
24.6
22.5
20.8
18.2
12.2
40 - 49
n=
514
422
391
366
334
315
283
250
225
197
183
164
142
125
110
94
80
64
48
36
24
18
13
8
5
1
%
100.0
84.3
81.6
79.3
75.5
73.4
69.8
65.3
62.3
58.6
57.4
56.1
52.2
51.0
48.1
44.0
40.6
36.8
33.1
28.7
25.9
24.7
24.7
24.7
24.7
24.7
50 -59
n=
272
211
190
173
161
148
134
121
105
88
74
68
59
51
43
32
28
24
16
12
9
7
2
2
1
%
100.0
81.2
76.5
75.3
73.9
72.5
70.0
67.8
62.1
60.8
56.5
56.5
53.8
52.9
49.6
43.4
43.4
41.8
35.9
33.5
33.5
33.5
26.8
26.8
26.8
2 OF THE 16 CASES IN THE GREATER THAN 59 YEARS CATEGORY ARE HETEROTOPIC HEART TRANSPLANTS
*
>59
n=
16
9
7
7
6
4
3
3
2
1
1
1
1
1
1
1
%
100.0
56.3
43.8
43.8
37.5
30.7
23.0
23.0
15.3
15.3
15.3
15.3
15.3
15.3
15.3
15.3
ANZCOTR 2013
ACTUARIAL SURVIVAL DONOR
AGE HEARTS 1984 - 2013
100
0-16yrs v 40-49yrs
0-16yrs v 50-59yrs
17-39yrs v 40-49yrs
17-39yrs v 50-59yrs
80
p<0.001
p<0.005
p<0.001
p<0.009
60
40
Percent
Survival
20
0
0
1
2
YEAR
3
4
5
6
7
8
0 - 16
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
17 - 39
40 - 49
50 -59
>59
2 OF THE 11 CASES IN THE GREATER THAN 59 YEARS CATEGORY ARE HETEROTOPIC HEART TRANSPLANTS
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ANZCOTR 2013
ACTUARIAL SURVIVAL DONOR
GENDER HEARTS 1984 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
Fem ale
n=
755
610
566
528
497
468
421
392
347
294
271
246
221
203
177
152
131
113
90
76
61
45
30
23
13
7
3
2
1
%
100.0
83.2
80.8
78.7
77.6
75.8
72.2
70.3
67.3
62.0
60.1
58.5
56.8
55.7
52.3
48.6
45.6
43.8
40.1
36.8
35.8
33.8
30.4
29.2
27.7
27.7
22.6
22.6
22.6
Male
n=
1608
1395
1306
1238
1156
1083
1005
928
859
787
709
631
558
490
440
384
325
279
239
205
165
129
94
71
55
31
18
12
5
3
%
100.0
88.7
86.2
84.1
81.3
79.0
76.2
72.9
70.2
67.5
64.2
61.2
57.2
54.8
51.8
48.4
44.5
41.6
39.2
37.4
35.8
33.0
30.5
28.7
27.3
24.3
23.4
21.9
19.4
19.4
ANZCOTR 2013
ACTUARIAL SURVIVAL DONOR
GENDER HEARTS 1984 - 2013
100
80
p=ns
60
Percent
Survival
40
20
0
0
1
2
3
4
5
Year
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
Female
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
Male
ANZCOTR 2013
ACTUARIAL SURVIVAL RECIPIENT
GENDER HEARTS 1984 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
Female
n=
%
Male
n=
%
528
441
416
385
355
330
295
268
247
215
193
169
150
128
116
103
90
79
68
58
49
38
29
22
15
9
5
3
1
100.0
86.5
84.5
81.8
80.5
79.1
75.9
72.5
71.9
68.6
65.0
61.5
58.5
55.6
52.5
50.1
47.6
46.5
44.6
43.2
43.2
41.3
38.9
34.6
32.8
30.1
22.6
22.6
22.6
1836
1565
1455
1381
1299
1221
1129
1052
959
865
787
707
629
564
500
433
366
312
261
222
176
135
95
71
53
29
16
11
5
100.0
87.1
84.5
82.5
80.0
77.7
74.7
71.9
68.6
65.1
62.4
60.0
56.6
54.8
51.7
47.9
44.0
41.1
38.1
35.8
34.0
31.3
28.5
27.4
26.2
23.7
23.7
22.0
19.4
1
22.6
2
14.6
ANZCOTR 2013
ACTUARIAL SURVIVAL RECIPIENT
GENDER HEARTS 1984 - 2013
100
80
Percent
Survival
p=ns
60
40
20
0
0
1
2
3
Year
4
5
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
Female
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
Male
ANZCOTR 2013
ACTUARIAL SURVIVAL ISCHAEMIC
TIME HEARTS 1984 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
<2hrs
n=
%
346
296
277
265
255
245
228
217
202
189
174
163
153
149
137
122
114
104
96
85
71
61
52
37
28
19
11
9
5
3
177
100.0
88.0
85.0
81.9
79.4
77.5
73.7
71.1
66.5
63.2
59.1
57.4
54.6
53.9
50.2
46.8
44.1
43.3
41.2
38.6
36.7
34.0
31.1
27.8
26.9
26.9
25.2
25.2
21.8
17.0
17.0
2-4 hrs
n=
%
1141
981
923
872
808
758
697
644
589
532
487
446
393
349
321
285
241
206
171
146
118
89
58
47
35
17
9
4
1
100.0
88.0
85.6
83.8
81.2
78.7
75.6
72.3
69.4
66.0
63.4
60.3
56.7
53.7
50.9
47.7
43.5
40.5
37.6
35.7
34.4
31.9
28.6
28.0
26.0
22.3
20.7
17.7
17.7
4-6 hrs
n=
%
695
581
534
501
469
434
395
361
327
282
250
213
182
155
127
105
83
67
52
42
32
23
14
10
5
2
1
1
100.0
85.7
83.9
82.0
80.1
78.2
75.6
72.9
70.8
66.9
64.5
61.7
58.1
57.4
53.9
49.8
46.8
43.2
39.0
36.6
35.6
33.1
33.1
33.1
33.1
24.8
24.8
24.8
>6 hrs
n=
%
166
138
130
120
113
106
99
91
81
71
63
51
47
36
28
22
17
14
9
7
5
1
100.0
85.4
81.0
77.8
76.5
75.1
73.7
72.1
71.3
68.6
66.5
64.2
62.9
60.0
58.1
53.7
51.0
47.8
47.8
47.8
47.8
47.8
ANZCOTR 2013
ACTUARIAL SURVIVAL ISCHAEMIC
TIME HEARTS 1984 - 2013
100
80
p=ns
60
40
20
0
0
1 2
3
4
5
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
<2hrs
2-4 hrs
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
4-6 hrs
>6 hrs
ANZCOTR 2013
ACTUARIAL SURVIVAL CROSSMATCH
HEARTS 1984 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
Positive
n=
164
129
120
109
102
95
82
75
72
65
60
54
46
44
41
38
32
25
25
21
17
11
8
7
6
3
1
1
%
100.0
79.8
77.9
74.5
73.8
72.3
68.4
64.1
62.4
58.0
54.4
52.6
47.5
47.5
47.5
44.1
40.4
36.4
36.4
30.6
30.6
26.5
26.5
26.5
26.5
21.2
21.2
21.2
Negative
n=
2017
1728
1619
1544
1469
1396
1293
1202
1100
995
909
818
731
647
575
497
424
367
304
260
209
163
116
87
62
35
20
13
6
3
1
%
100.0
87.3
84.8
82.9
80.7
78.6
75.6
72.8
69.9
66.6
63.8
61.1
58.0
55.8
52.5
49.0
45.3
42.8
39.8
38.0
36.4
33.9
30.9
29.1
27.6
25.4
23.6
22.2
20.0
16.0
16.0
ANZCOTR 2013
ACTUARIAL SURVIVAL
CROSSMATCH HEARTS 1984 - 2013
100
80
p < 0.01
60
Percent
Survival
40
20
0
0
1
2
3
4
5
Year
6
7
8
9
10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
Positive
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
Negative
ANZCOTR 2013
ACTUARIAL SURVIVAL PEAK PANEL REACTIVE
ANTIBODIES ALL HEARTS 1984 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
PRA<15%
n=
%
2136
1818
1706
1613
1517
1422
1305
1210
1099
989
890
796
705
624
557
486
416
359
301
257
208
159
113
84
59
30
18
11
5
2
100.0
87.0
84.5
82.4
80.4
78.2
75.2
72.5
69.5
66.2
63.2
60.8
57.4
55.3
52.4
49.0
45.4
42.8
39.7
37.3
35.8
33.1
30.1
28.3
27.2
24.3
23.3
21.7
19.2
14.4
PRA≥15
n=
%
221
182
166
154
137
130
121
110
107
95
90
81
74
69
60
50
40
33
28
24
18
15
11
10
9
8
3
3
1
1
1
100.0
85.7
84.2
81.1
76.8
75.1
72.2
67.3
66.7
61.6
60.3
54.9
52.2
51.4
46.9
42.8
38.3
36.2
36.2
36.2
36.2
34.1
34.1
34.1
30.7
30.7
25.6
25.6
25.6
25.6
25.6
ANZCOTR 2013
ACTUARIAL SURVIVAL PEAK PRA
ALL HEARTS 1984 - 2013
100
80
p=ns
60
Percent
Survival
40
20
0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
Year
PRA<15%
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
PRA>=15%
ANZCOTR 2013
ACTUARIAL SURVIVAL CMV
STATUS HEARTS 1984 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
Donor Neg
Rec Neg
n=
376
317
294
280
265
252
233
218
201
186
168
152
130
115
97
90
80
72
66
60
46
30
19
14
12
5
3
2
2
%
100.0
87.8
85.5
84.1
81.0
80.1
78.1
76.1
74.3
72.0
67.3
64.8
60.8
57.9
53.2
52.1
49.7
47.7
45.1
43.6
42.0
37.8
33.5
33.5
31.0
24.5
19.0
19.0
19.0
Donor Pos
Rec Neg
n=
418
350
325
306
285
273
254
232
216
197
179
158
142
122
113
99
87
71
58
50
42
32
27
21
12
7
4
1
%
100.0
85.7
82.7
80.9
79.0
76.8
73.4
70.4
68.2
65.3
64.0
61.7
59.7
57.9
56.5
53.4
50.6
46.3
44.2
40.3
40.3
39.2
39.2
39.2
36.9
36.9
36.9
36.9
Recipient
Pos
n=
1528
1307
1225
1158
1082
1008
922
859
779
690
627
562
501
450
403
343
287
248
203
169
136
110
76
57
42
24
12
9
2
1
%
100.0
87.3
84.9
82.9
80.8
78.4
75.1
72.3
69.1
65.4
62.6
59.7
56.2
54.3
51.1
46.9
42.8
40.5
37.4
35.4
33.6
31.0
27.8
25.4
24.4
22.3
21.1
19.2
19.2
19.2
ANZCOTR 2013
ACTUARIAL SURVIVAL CMV
STATUS HEARTS 1984 - 2013
100
80
p=ns
60
Percent
Survival
40
20
0
0
1
2
3
4
5
Year
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
R-ve/D-ve
R-ve/D+ve
R+ve = R+veD+ve or R+veD-ve
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
R+ve
ANZCOTR 2013
ACTUARIAL SURVIVAL HLA
MISMATCH HEARTS 1984 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
MM0
n=
2
2
1
%
100.0
50.0
0.0
MM1
n=
5
5
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
%
100.0
100.0
100.0
100.0
100.0
66.7
66.7
66.7
66.7
66.7
66.7
66.7
66.7
66.7
66.7
66.7
66.7
66.7
66.7
66.7
66.7
66.7
MM2
n=
33
26
26
26
26
23
23
22
20
19
18
15
14
13
11
11
8
8
7
5
4
4
4
4
2
1
%
100.0
78.8
78.8
78.8
78.8
75.6
75.6
72.3
69.0
65.5
65.5
61.7
57.6
53.5
49.2
49.2
39.8
39.8
39.8
39.8
39.8
39.8
39.8
39.8
39.8
19.9
MM3
n=
115
103
96
92
91
86
83
73
69
64
56
52
48
47
42
37
32
28
25
24
19
13
8
4
2
%
100.0
90.4
89.5
87.6
87.6
84.7
82.7
78.6
77.5
75.2
72.7
71.4
67.2
67.2
65.7
64.1
62.3
58.2
56.1
56.1
56.1
49.5
40.9
40.9
40.9
MM4
n=
351
296
280
268
248
226
205
192
165
154
141
124
115
108
97
83
70
59
53
48
34
26
19
15
12
8
5
3
1
%
100.0
85.4
83.6
83.0
81.1
78.1
74.2
72.0
66.2
62.6
58.8
55.8
54.4
53.0
49.5
43.8
39.4
35.9
34.7
34.7
32.2
31.2
29.8
28.1
26.1
23.6
20.2
15.7
15.7
MM5
n=
812
703
653
609
576
547
502
463
430
388
359
321
287
250
222
192
163
138
112
94
77
63
45
34
23
14
9
6
3
2
%
100.0
89.7
87.3
84.9
82.9
81.2
78.2
74.5
72.1
68.4
65.1
61.5
58.7
56.4
53.4
49.6
46.1
43.4
38.8
35.9
34.3
33.3
30.4
28.2
27.2
24.4
24.4
24.4
19.5
19.5
MM6
n=
%
1046 100.0
872 85.1
813 82.3
769 79.8
710 76.9
667 74.8
614 71.9
570 69.5
520 67.2
454 63.9
406 61.5
366 59.6
314 55.2
274 53.2
244 50.0
212 47.3
182 43.8
159 41.8
131 39.5
109 36.7
91
35.6
67
31.4
48
29.2
37
27.9
29
26.3
15
25.1
7
22.9
5
22.9
2
22.9
1
11.5
ANZCOTR 2013
ACTUARIAL SURVIVAL HLA
MISMATCH HEARTS 1984 - 2013
100
p<0.05
80
Percent
Survival
60
40
20
0
0
1
2
3
4
5
6
7
8
9
10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
Year
MM0
MM1
MM2
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
MM3
MM4
MM5
MM6
ANZCOTR 2013
ACTUARIAL SURVIVAL HLA DR
LOCUS MISMATCH HEARTS 1984 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
MM0
n=
72
61
55
48
47
45
40
36
34
31
30
26
23
22
20
20
16
15
13
12
11
9
5
5
3
1
%
100.0
86.0
83.1
78.4
78.4
76.7
69.8
68.0
68.0
63.9
63.9
61.7
56.9
54.4
51.9
51.9
46.4
46.4
43.2
43.2
43.2
43.2
32.4
32.4
32.4
19.4
MM1
n=
484
42
389
374
356
326
304
284
257
235
213
191
171
157
139
122
102
91
77
68
49
39
32
24
15
9
4
4
3
1
%
100.0
89.5
87.5
86.4
85.2
82.0
79.7
77.3
73.4
69.6
66.0
62.8
59.1
57.7
53.9
51.1
46.3
43.5
40.0
39.0
37.0
34.6
33.6
31.3
29.7
27.3
23.4
23.4
17.6
17.6
MM2
n=
1808
1526
1429
1345
1251
1181
1083
1002
915
815
738
662
585
514
458
394
338
287
239
201
166
126
87
65
50
28
17
10
3
2
1
%
100.0
86.3
83.7
81.5
78.9
76.9
73.9
70.8
68.2
64.9
62.1
59.6
56.4
54.3
51.4
47.6
44.3
41.7
39.1
36.5
35.1
32.4
29.5
27.9
26.5
24.6
23.5
21.8
21.8
14.5
14.5
ANZCOTR 2013
ACTUARIAL SURVIVAL HLA DR LOCUS
MISMATCH HEARTS 1984 - 2013
100
80
p= ns
60
Percent
Survival
40
20
0
0
1
2
3
4
Year
5
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
MM0
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
MM1
MM2
ANZCOTR 2013
ACTUARIAL SURVIVAL MALIGNANCIES
HEART 1984 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
PTLD
n=
95
89
87
84
75
72
67
58
56
50
46
40
36
36
33
28
25
20
15
11
11
9
7
7
5
3
3
2
2
%
100.0
93.7
91.6
88.4
81.0
78.8
74.4
65.4
63.2
57.5
52.9
47.1
42.4
42.4
38.8
35.2
31.4
27.5
23.2
19.8
19.8
18.0
18.0
18.0
18.0
18.0
18.0
18.0
18.0
OTHER
MALIGNANCIES
(invasive skin/other)
n=
501
493
485
478
460
442
416
395
373
348
323
300
275
259
239
209
175
151
127
104
79
57
41
31
21
13
6
4
2
*Survival of the group who were defined by having developed a malignancy
%
100.0
98.4
97.0
96.0
93.0
89.9
85.2
81.9
78.0
74.0
69.9
66.4
62.6
60.5
56.8
52.1
46.5
41.6
38.2
34.1
32.3
27.5
23.8
21.3
19.7
18.6
16.7
16.7
16.7
ANZCOTR 2013
ACTUARIAL SURVIVAL
MALIGNANCIES HEARTS 1984 - 2013
100
90
80
70
Percent
Survival
60
50
40
30
20
10
0
ptld v other mal p=<0.005
0
1
2
3
Year
4
5
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
PTLD
OTHER MALIGNANCIES
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ANZCOTR 2013
RECIPIENT CAUSE OF DEATH - HEARTS
1984 - 2013
n = 1114
27%
300
18%
250
No of Deaths
200
14%
15%
10%
150
7%
100
4%
4%
50
0
1%
TxCAD
Misc
Infection
Acute
Rejection
Other
NSGF
Malignancies
PTLD
CVA Hemorrhage
ANZCOTR 2013
CAUSE OF DEATH HEARTS 1984 - 2013
Transplant Coronary Artery Disease (TxCAD)
Other Malignancy (non PTLD)
Infection
Acute Rejection
Non-specific Graft Failure (NSGF)
PTLD
CVA
Hemorrage
201
171
153
106
83
45
42
15
OTHER TOTAL(incl unspecified)
Total all Deaths = 1114
298
60
30
29
29
17
16
12
9
7
7
6
5
5
5
4
3
3
2
2
Renal Failure
Sudden Death
Multi-organ Failure
Cardiac Arrest/MI
Heart Failure
TxCAD + Rejection
Pulmonary/Resp Failure
Non-compliance
Suicide
Pancreatitis
Motor Vehicle Accident
Liver Failure
Bowel Ischaemia
Post Surgical Complication
Right Ventricular Failure
Pulmonary Hypertension
Pulmonary Embolism
Drug Overdose
Aortic Dessection (Marfan's)
congenital bronchomalacia (1), pericarditis(1), peripheral vascular disease(3), anoxic brain/head inj(2)
acute abdomen (2), myelodysplasia (1), esophogeal perforation (1)drug induced lung damage (1)
esophageal diverticulum (1) COPD (3) Hepatic Encephalopathy (2) Gen. deterioration (4)
amyloidosis (1), Parkinson's(1),mesenteric ischemia(1), died on table(2) aortic aneurism(2)
Brain stem bleed (2), dissenting myopathy (1), stroke (2), Motor Neuron Disease (1)
Unspecified (data pending)
13
ANZCOTR 2013
CAUSE OF DEATH ALL HEARTS
<5 YEARS AFTER TX 1984-2013
No
%
Infection
108
22
Misc (incl 4 no data
87
17
Rejection
86
17
Non Specific Graft Failure
67
14
Graft Atherosclerosis (TxCAD)
56
11
Non Lymphoid Malignancy
30
6
Lymphoproliferative Disease
13
3
CVA
20
4
Haemorrhage
12
2
Graft Atherosclerosis & Rejection
9
2
Pulmonary Failure
6
1
Pulmonary Hypertension
2
1
Totals
495
100.0
ANZCOTR 2013
CAUSE OF DEATH ALL HEARTS ≥5
YEARS AFTER TX 1984-2013
No
%
Misc (incl data pending)
178
29
Graft Atherosclerosis (TxCAD)
145
23
Non Lymphoid Malignancy
141
23
Infection
45
7
Lymphoproliferative Disease
32
5
Rejection
20
3
CVA
22
4
Non Specific Graft Failure
16
3
Pulmonary Failure
6
1
Haemorrhage
3
0.5
Graft Atherosclerosis & Rejection
7
1
Pulmonary Hypertension
1
0.5
Totals
619
100.0
ANZCOTR 2013
MALIGNANCIES* - HEART
n = 596
1984 - 2013
PTLD 16 %
Other 84 %
*the count of initial diagnosis only
ANZCOTR 2013
MALIGNANCIES - HEART N=596 1984 - 2013
PTLD
Skin
Metastatic SCC
Melanoma
BCC
Spindle Cell
Merkle Cell
Dermatofibrosarcoma
95
95/2364=4%
241
35
72
2
3
2
355
355/2364=15%
Other
146/2364=6.2%
Lung
Bowel
Prostate
Liver
Renal
Bladder
Tonsil/throat/tongue
Parotid
Oesophagus
Mesothelioma
Pancreas
Cervix
Thyroid/Parathyroid
Breast
Larynx
Caecum
Testicle
Carcinoid Tumour
Ear/Face/Neck
Brain
Uterus
Endometrium
Leiomyosarcoma
Leukaemia
Liposarcoma
Mediastinum
Neuroblastoma
Pituitary
Seminoma
Bone
Unspecified
32
18
16
11
7
6
5
4
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
7
ANZCOTR 2013
Reason for Transplant
Heart Lung 1986 - 2013
Misc 7%
Bronchiectasis 2%
CFA 3%
PPH 26%
Cystic Fibrosis 14%
Congenital Heart Disease 14%
Eisenmenger’s 21%
Emphysema 3%
AAT deficiency 7%
Other PH 3%
ANZCOTR 2013
REASON FOR TRANSPLANT HEART
LUNG n = 182 1986 - 2013
Primary Pulmonary Hypertension
Eisenmenger's Syndrome
Congenital Heart Disease
Cystic Fibrosis
Alpha-1-Antitrypsin Deficiency
Emphysema
Cryptogenic Fibrosing Alveolitis
Other Pulmonary Hypertension
Bronchiectasis
Miscellaneous
47
37
26
25
13
6
5
6
4
13
Total
182
ANZCOTR 2013
Reason for Transplant
Single Lung 1990 - 2013
Misc 6%
Bronchiectasis 1%
Other PH / Eisenmengers / CF 1%
AAT
16%
IPF 25%
Emphysema 51%
ANZCOTR 2013
REASON FOR TRANSPLANT
SINGLE LUNG 1990 - 2013 n = 476
Emphysema
Idiopathic Pulmonary Fibrosis
Alpha-1-Antitrypsin Deficiency
*Miscellaneous lung
Bronchiectasis
Other Pulmonary Hypertension
Eisenmenger's Syndrome
Cystic Fibrosis
242
119
74
31
5
2
1
1
*Lymphangioleiomyomatosis(5), OB(4), PLAM(4), sarcoidosis(3),
pulmonary eosinophillic granulomatosis(2), allergic alveolitis(3), tuberous sclerosis(2),
severe air flow obstruction(1), Histiocytosis X(2), alveolar cell sarcoma(1), asthma(1),
Agammaglobulinaemia(1), hypersensitive pneuminitis(1) UIP(1), LIP(1)
ANZCOTR 2013
Reason for Transplant
Bilateral Lung 1992 – 2013 n =1704
Eisenmengers 1%
IPF 10%
Misc 9%
Bronchiectasis 8%
PPH 4%
Other PH 1%
AAT 7%
Emphysema 27%
Cystic Fibrosis 33%
ANZCOTR 2013
REASON FOR TRANSPLANT
BILATERAL LUNG 1992 - 2013 n = 1704
Cystic Fibrosis
Emphysema
Idiopathic Pulmonary Fibrosis
Bronchiectasis
Alpha-1-Antitrypsin Deficiency
Primary Pulmonary Hypertension
Other Pulmonary Hypertension
Eisenmengers Syndrome
*Miscellaneous lung
* ILD(50), OB(24), sarcoidosis(24), PLAM (21), histiocytosis X(8), asthma (7), alveolitis(6),
568
452
173
137
118
70
18
10
158
1704
eosinophilic granulomatosis(3), ARDS(3), silicosis(1), diffuse alveolar damage(2),
cystic lung disease (2), x -linked hypogammaglobulinemia(2), graft v host(1),
viral pneumonia(1), Wegeners granulomatosis(1), surficant c deficiency(1),
alveolar proteinosis(1), microlithiasis(1), pulmonary veno occlusive disease(1),
pulmonary capillary hemangiomatosis (1) hypersensitive pneumonitis(1)
ANZCOTR 2013
Donor / Recipient State of Origin
All Lungs 1986 - 2013
800
700
600
500
400
300
200
100
0
lk
Is
l
NZ
No
rfo
TA
S
A
W
SA
C
VI
LD
Q
NS
W
NT
AC
T
Number
Recipients 86 - 13
Donors 86 - 13
ANZCOTR 2013
*Retransplants and unknown state of origins are not included
DONOR / RECIPIENT STATE OF
ORIGIN ALL LUNGS 1986 - 2013
Location
Recipients 86-13
%
Donors 86-13
%
Recipients 13
%
Donors 13
%
ACT
NT
NSW
QLD
VIC
SA
WA
TAS
NZ
Norfolk Isl
23
4
694
324
678
163
191
88
186
1
1.0
0.2
29.5
13.8
28.8
6.9
8.1
3.7
7.9
0.0
53
30
621
371
580
226
172
57
248
0
2.2
1.3
26.3
15.7
24.6
9.6
7.3
2.4
10.5
0
1
0
47
34
49
11
11
8
19
0
0.6
0.0
26.1
18.9
27.2
6.1
6.1
4.4
10.6
0.0
2
3
42
35
42
12
21
4
19
0
1.1
1.7
23.3
19.4
23.3
6.7
11.7
2.2
10.6
0.0
Total
2352
100.0
2358
100.0
180
100.0
180
100.0
*Retransplants and unknown state of origins are not included
ANZCOTR 2013
Mean Wait to Transplant
All Lungs 1990 - 2013
300
250
200
Days
150
100
50
0
90
92
94
96
98
0
2
4
mean wait in days
6
8
10
12
Year
ANZCOTR 2013
MEAN WAITING TIME TO LUNG
TRANSPLANT – DAYS 1990 - 2013
year
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
n
17
37
48
70
83
84
81
90
92
76
103
85
108
91
109
92
108
87
120
125
130
166
156
180
mean
194
273
209
211
272
297
205
260
215
242
197
241
226
221
285
211
188
192
228
234
221
197
186
161
std dev
168
234
217
259
239
295
205
251
178
204
199
231
215
217
256
239
221
195
244
261
216
225
216
202
median
136
202
148
119
201
165
132
166
186
195
135
169
161
163
197
130
119
130
130
125
149
108
120
91
min-max
2-500
5-1034
1-1075
7-2325
8-1048
8-1679
7-1009
6-1839
1-1221
7-939
1-900
1-1199
7-1333
3-1336
4-1545
5-1350
0-1146
6-1494
1-2864
1-1322
0-1297
1-1601
0-1195
0-1302
ANZCOTR 2013
Mean Recipient Age at Transplant
LUNGS 1989 - 2013
70
60
Age in
Years
50
40
30
20
10
0
89 90 91 92 93 94 95 96 97 98 99 0 1 2 3 4 5 6 7 8 9 10 11 12 13
HLTx
SLTx
BSLTx
ANZCOTR 2013
MEAN RECIPIENT AGE AT LUNG
TRANSPLANT 1989 - 2013
HLTx
year
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
n mean std dev min-max
11-46
12
32
20-51
10
37
19-46
11
34
15-49
12
31
12-48
13
31
14-46
10
32
24-52
11
38
18-37
6
26
23-42
9
36
13-43
14
26
4
22-53
na
38
2
22-46
na
34
2
40
na
40
1
22-49
10
35
9
13-55
18
36
5
21-47
10
36
6
25-46
8
37
5
9-45
14
25
6
15-48
12
38
6
25-45
9
36
5
29-31
na
30
2
17-51
18
37
3
50-57
na
54
2
18-37
9
25
4
27-49
na
38
2
SLTx
year
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
n
38
27
28
29
29
21
13
10
17
8
11
12
10
12
3
5
mean std dev min-max
48
46
46
51
49
51
54
51
51
55
55
56
57
57
56
61
54
57
60
58
58
59
57
62
5
8
7
3
6
7
6
6
9
7
6
9
5
7
6
3
7
5
4
14
6
5
9
5
42-55
32-57
26-57
46-57
30-57
22-59
30-60
35-62
30-65
37-64
39-65
32-69
43-66
42-66
48-64
57-66
34-60
50-64
54-68
14-67
42-64
53-68
47-63
56-67
BSLTx
year
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
n
3
33
44
43
42
43
50
47
73
55
70
65
90
77
85
73
106
111
117
152
149
173
mean std dev min-max
34
34
36
35
39
37
38
36
40
38
39
41
44
44
45
45
44
46
45
47
47
49
17
13
10
13
14
14
14
13
13
14
14
15
14
14
16
15
15
15
16
16
15
14
ANZCOTR 2013
19-52
19-56
19-54
16-60
13-60
14-61
14-60
15-62
14-63
13-60
14-65
17-64
15-65
16-64
15-66
9-63
15-69
11-64
11-69
7-69
12-69
14-67
Mean Donor Age at Transplant
ALL LUNGS 1989 - 2013
60
50
Years 40
of Age
30
20
10
0
89 90 91 92 93 94 95 96 97 98 99 0
HLTx
1
SLTx
2
3
4
5
6
7
8
9 10 11 12 13
BSLTx
ANZCOTR 2013
MEAN DONOR AGE AT
TRANSPLANT LUNGS 1989 - 2013
HLTx
year
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
n mean std dev min-max
14
23
11
11-43
12
25
10
12-47
19
29
7
17-43
18
26
11
11-44
13
27
14
10-55
13
33
13
15-53
13
33
13
10-50
7
32
16
14-49
4
31
13
17-45
4
32
15
16-51
2
53
na
51-55
2
21
na
15-26
1
50
na
50-50
9
37
12
18-50
5
35
16
8-49
6
37
16
12-52
5
33
18
11-58
6
20
16
7-48
6
28
16
13-50
5
39
18
17-58
2
33
na
15-50
3
37
18
17-51
2
53
na
46-60
4
34
11
23-43
2
39
na
30-47
SLTx
year
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
n
5
18
27
24
26
28
32
43
38
27
28
29
29
21
13
10
17
8
11
12
10
12
3
5
mean std dev min-max
32
30
34
32
29
33
38
37
35
37
41
35
35
40
33
32
41
47
40
34
58
59
21
28
12
11
9
12
9
12
12
13
13
17
17
13
13
15
13
14
18
19
12
19
6
5
3
10
18-49
15-53
18-50
14-55
17-50
18-56
14-54
12-56
16-58
15-62
17-66
16-53
12-62
18-61
19-56
13-47
13-64
17-61
19-56
16-62
42-64
53-68
18-23
18-41
BSLTx
year
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
n
3
33
44
43
42
43
50
47
73
55
70
65
88
77
85
73
106
111
117
149
150
173
mean std dev min-max
21
31
33
33
34
33
35
40
38
33
36
35
36
40
35
37
38
39
42
43
44
43
3
13
13
12
12
14
13
14
13
15
16
14
15
13
15
15
15
16
15
17
16
17
ANZCOTR 2013
18-24
15-55
12-55
9-58
10-60
12-55
10-62
14-59
11-61
10-59
7-64
8-62
7-64
9-64
11-62
10-62
9-67
15-65
5-70
8-72
11-73
9-74
LUNGS MEAN ISCHAEMIC TIME
1989 - 2013
500
400
Minutes
300
200
100
0
89 90 91 92 93 94 95 96 97 98 99 0
SLTx
1
2
BSLTx
3
4
5
6
7
8
9 10 11 12 13
HLTx
ANZCOTR 2013
LUNGS - MEAN ISCHAEMIC TIME
1989 - 2013 MINUTES
year
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
HLTx
mean std dev min-max
144
40
99-207
230
103
103-408
264
144
98-705
274
100
107-419
258
89
167-413
257
99
137-500
211
61
130-310
279
116
188-496
270
146
144-472
205
50
144-251
366
na
350-381
355
na
199-510
455
na
455-455
337
108
186-456
293
146
118-460
315
115
168-448
281
174
112-509
278
105
161-402
231
49
176-308
257
104
140-402
137
na
109-164
289
115
207-420
208
na
177-238
234
76
125-289
292
na
283-300
SLTx
mean std dev min-max
238
226
282
315
280
304
276
290
332
306
346
351
335
344
331
304
304
292
286
311
280
247
213
304
47
108
107
124
109
94
123
117
141
111
153
133
128
123
193
111
146
146
91
116
111
85
77
151
180-310
18-450
103-455
155-543
110-465
144-485
105-515
110-525
97-740
138-560
93-612
117-623
99-564
122-510
155-735
141-452
120-532
140-570
185-423
145-535
150-450
144-385
134-287
119-486
BSLTx
mean
425
420
382
362
342
361
379
346
357
383
367
377
324
327
327
342
335
326
325
338
320
311
std dev min-max
52
85
127
117
127
135
123
108
123
122
125
112
109
84
104
121
115
114
91
97
108
107
390-485
221-568
195-655
180-600
157-656
100-675
160-623
121-579
144-655
198-815
156-850
185-635
150-735
131-540
95-625
127-609
129-880
119-635
160-577
128-657
124-622
125-639
ANZCOTR 2013
Recipient Gender % Lung
Transplants 1986 - 2013
70
55
60
50
51
49
45
47
53
%
40
30
20
10
0
Bilateral Lung
Single Lung
Male
Heart Lung
Female
ANZCOTR 2013
Recipient Gender Lung
Transplants 1986 - 2013
Transplant Type
Male no
%
Female no
%
Bilateral Lung
871
51
833
49
Single Lung
264
55
212
45
Heart Lung
85
47
96
53
ANZCOTR 2013
ACTUARIAL SURVIVAL
ALL LUNGS 1986 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
HLTx
n=
181
142
123
109
97
88
82
77
65
59
57
51
46
42
39
35
32
29
26
23
20
14
7
6
%
100.0
79.4
69.3
62.0
55.7
51.1
49.3
47.5
43.0
42.3
41.6
39.4
37.8
36.1
33.5
30.9
30.0
29.0
28.0
26.9
25.6
21.5
19.5
19.5
SLTx
n=
476
388
342
282
240
206
172
157
129
110
92
74
56
43
32
24
19
15
10
6
5
4
2
%
100.0
82.3
73.1
61.9
53.5
47.4
40.6
37.3
32.0
28.2
24.3
21.3
18.8
16.0
14.0
12.6
10.0
8.8
8.2
8.2
8.2
8.2
8.2
BSLTx
n=
1704
1398
1139
915
747
614
506
440
364
303
250
187
139
110
83
63
45
26
20
12
4
%
100.0
88.5
79.8
72.6
67.1
61.8
57.7
55.0
51.2
47.6
44.4
41.7
37.8
36.9
33.9
32.6
30.8
28.3
24.9
24.9
21.9
ANZCOTR 2013
ACTUARIAL SURVIVAL ALL LUNG
TRANSPLANTS 1986 - 2013
100
80
SL v HL p<0.005
SL v BL p<0.005
60
Percent
Survival
40
20
0
0
1
2
3
Year
4
5
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
HLTx
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
SLTx
BSLTx
ANZCOTR 2013
ACTUARIAL SURVIVAL DCD DONORS V DBD
DONORS 2006 - 2013
100
80
60
Percent
Survival
p=ns
40
20
0
0
1
Year
2
3
DCD Donors
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
4
5
6
7
NON DCD Donors
ANZCOTR 2013
8
ACTUARIAL SURVIVAL DCD DONORS v DBD DONORS
2006 - 2013
%
NON DCD
n=
%
133
106
76
51
28
100.0
91.2
81.7
74.3
70.7
905
696
534
378
265
100.0
89.0
81.9
75.0
69.4
12
8
3
70.7
70.7
70.7
177
94
52
64.0
59.0
58.2
DCD ONLY
n=
0
1
2
3
4
5
6
7
Year
ANZCOTR 2013
ACTUARIAL SURVIVAL DONOR
AGE ALL LUNGS 1986 - 2013
100
80
0-16 yrs vs 40-49yrs
Percent
Survival
p<0.05
17-39yrs vs 40-49yrs p<0.05
60
40
20
0
0
1
2
YEAR
3
4
5
6
7
8
0-16
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
17 - 39
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
40 - 49
> 49
ANZCOTR 2013
ACTUARIAL SURVIVAL DONOR
AGE ALL LUNGS 1986 – 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
0-16
n=
179
151
130
112
94
80
71
63
50
43
37
33
28
22
17
14
11
7
6
5
4
2
2
2
%
100.0
87.5
80.3
75.2
68.2
63.0
60.5
57.8
51.1
48.9
44.3
43.0
41.7
41.7
37.6
37.6
34.7
34.7
34.7
28.9
28.9
20.7
20.7
20.7
17 - 39
n=
1056
876
746
641
544
465
397
357
302
257
222
169
132
110
89
77
61
47
39
30
20
13
6
4
2
%
100.0
86.7
78.2
70.7
64.7
59.7
54.7
51.7
47.1
42.3
39.2
36.1
32.5
30.7
28.6
26.9
24.7
23.3
21.8
21.8
20.1
17.8
17.8
17.8
17.8
40 - 49
n=
522
432
357
280
232
194
156
137
113
94
76
62
52
38
30
19
13
9
6
4
3
2
2
%
100.0
86.5
76.8
65.6
60.0
54.1
49.1
46.1
42.6
41.0
36.0
33.5
31.2
28.6
25.4
21.5
19.0
15.8
15.8
15.8
15.8
15.8
15.8
50+
n=
604
469
371
273
214
169
136
117
93
78
64
48
29
25
18
12
11
7
5
2
2
1
1
%
100.0
85.8
76.3
68.7
61.0
54.3
50.2
47.5
43.2
41.2
40.1
36.0
31.6
29.4
25.5
25.5
25.5
22.8
16.3
16.3
16.3
16.3
16.3
ANZCOTR 2013
ACTUARIAL SURVIVAL ISCHAEMIC
TIME ALL LUNGS 1986 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
<2hrs
n=
33
27
25
21
19
15
12
9
9
9
8
7
6
5
4
4
4
3
3
2
2
2
1
1
1
%
100.0
84.6
78.3
65.8
59.5
47.0
43.7
32.7
32.7
32.7
29.1
25.5
21.8
18.2
14.6
14.6
14.6
14.6
14.6
14.6
14.6
14.6
14.6
14.6
14.6
2-4 hrs
n=
510
416
346
279
233
199
172
155
122
107
87
75
55
49
38
30
25
23
21
17
14
9
5
3
2
%
100.0
87.4
80.0
69.7
64.4
59.6
56.4
53.4
47.2
43.7
39.8
37.9
34.5
33.2
28.9
25.7
24.8
24.8
23.7
22.5
21.1
17.7
17.7
17.7
17.7
4-6 hrs
n=
948
787
642
525
428
343
281
250
203
164
146
114
88
65
54
40
30
20
15
11
6
5
3
2
1
%
100.0
88.4
78.3
71.4
64.8
57.8
53.6
51.0
46.5
42.6
41.0
38.2
33.9
31.0
29.0
28.4
25.3
22.4
20.0
20.0
17.8
17.8
17.8
17.8
17.8
>6 hrs
n=
766
619
524
423
349
307
260
228
197
170
144
108
84
69
53
44
35
22
15
11
7
2
%
100.0
84.1
75.3
66.9
59.7
56.5
51.3
48.5
44.7
41.5
37.0
33.1
30.7
29.6
27.7
25.5
23.0
20.7
18.6
16.8
18.6
14.9
ANZCOTR 2013
ACTUARIAL SURVIVAL ISCHAEMIC
TIME ALL LUNGS 1986 - 2013
100
80
60
p=ns
Percent
Survival
40
20
0
0
1
2
Year
3
4
5
6
7
<2hrs
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
2-4 hrs
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
4-6 hrs
>6 hrs
ANZCOTR 2013
ACTUARIAL SURVIVAL CROSSMATCH
ALL LUNGS 1986 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
Positive
n=
%
138
117
104
79
66
58
50
47
40
34
30
22
16
15
11
10
10
7
6
4
3
2
1
1
100.0
86.1
78.0
65.4
60.2
56.5
52.4
50.3
43.8
39.3
36.9
32.9
28.1
28.1
24.1
24.1
24.1
21.4
21.4
21.4
16.1
16.1
16.1
16.1
Negative
n=
%
1910
1561
1307
1083
919
776
653
581
495
423
357
279
216
176
142
111
85
62
49
36
25
15
8
5
3
100.0
86.4
77.5
69.4
63.1
57.3
52.5
49.3
44.9
41.5
38.2
35.4
32.3
30.2
27.8
25.9
23.6
22.1
20.2
19.7
19.1
16.4
16.4
16.4
16.4
ANZCOTR 2013
ACTUARIAL SURVIVAL
CROSSMATCH LUNGS 1986 - 2013
100
80
60
Percent
Survival
p=ns
40
20
0
0
1 2
3 4
Year
5 6
7 8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Positive
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
Negative
ANZCOTR 2013
ACTUARIAL SURVIVAL CMV
STATUS ALL LUNGS 1986 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
Donor Neg
Rec Neg
n=
366
298
258
221
189
161
129
109
88
74
64
53
42
34
29
21
15
11
10
8
5
4
2
2
2
%
100.0
86.0
78.6
71.7
65.3
61.4
54.9
51.4
46.9
44.6
39.7
37.1
34.1
32.4
32.4
31.1
27.8
27.8
25.3
25.3
21.7
21.7
21.7
21.7
21.7
Donor Pos
Rec Neg
n=
457
380
314
263
215
188
160
144
119
99
83
63
52
41
31
28
21
12
9
7
6
1
1
%
100.0
90.0
79.5
73.2
65.6
61.2
56.5
53.6
47.8
44.0
40.7
38.0
36.7
33.7
30.2
29.2
24.8
23.3
23.3
23.3
23.3
17.5
17.5
Recipient
Pos
n=
1490
1212
1004
799
659
543
458
408
340
288
241
187
139
113
88
69
56
44
34
24
16
11
4
2
1
%
100.0
85.7
77.1
68.2
62.0
55.9
51.7
48.9
44.9
41.2
38.2
35.0
31.1
29.7
26.6
24.9
23.8
21.9
19.8
19.8
18.8
16.2
14.2
14.2
14.2
ANZCOTR 2013
ACTUARIAL SURVIVAL CMV
STATUS LUNGS 1986 - 2013
100
80
R-D+ vs R+
p<0.05
60
Percent
Survival
40
20
0
0
1 2
3 4
5 6
7 8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
R-ve/D-ve
R-ve/D+ve
R+ve
Years
R+ve = R+ve/D+ve or R+ve/D-ve
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ANZCOTR 2013
ACTUARIAL SURVIVAL HLA
MISMATCH ALL LUNGS 1986 - 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
MM0-1
n=
13
11
9
8
5
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
%
100.0
84.6
69.2
69.2
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
50.8
MM2
n=
26
21
18
16
12
10
8
8
7
7
7
6
6
6
5
3
2
1
%
100.0
80.8
69.2
69.2
60.0
60.0
48.0
48.0
42.0
42.0
42.0
42.0
42.0
42.0
35.0
35.0
35.0
17.5
MM3
n=
112
96
86
73
63
57
50
44
34
28
26
22
19
15
13
11
9
7
5
3
3
1
%
100.0
90.0
84.2
77.1
73.8
71.4
66.2
62.1
57.5
53.9
52.0
45.9
39.6
35.2
32.8
32.8
32.8
32.8
32.8
32.8
32.8
19.7
MM4
n=
338
280
238
186
148
123
105
93
77
62
56
48
41
37
29
22
15
11
9
6
4
2
1
1
%
100.0
87.6
79.5
70.0
61.0
55.8
52.9
50.3
44.7
38.7
36.8
33.4
32.0
31.2
27.6
25.5
22.9
21.2
21.2
21.2
21.2
21.2
21.2
21.2
MM5
n=
772
617
512
413
334
287
237
206
166
148
131
104
78
64
51
44
35
23
21
15
10
5
2
1
1
%
100.0
85.1
77.4
69.2
61.7
56.7
51.7
48.4
44.4
41.6
37.7
34.9
32.3
31.4
28.8
28.2
25.5
22.2
22.2
22.2
18.9
14.4
10.8
10.8
10.8
MM6
n=
1100
905
741
610
522
427
356
319
272
226
177
131
96
72
55
41
34
27
20
16
11
9
5
3
3
%
100.0
86.9
76.8
68.6
63.7
57.2
52.4
49.9
45.4
42.2
38.8
36.1
31.9
29.0
26.8
23.7
21.8
21.8
17.6
16.7
16.7
16.7
16.7
16.7
16.7
ANZCOTR 2013
ACTUARIAL SURVIVAL HLA
MISMATCH ALL LUNGS 1986 – 2013
100
80
MM0-1 v MM5
MM0-1 v MM6
p<0.05
p<0.05
60
Percent
Survival
40
20
0
0
1 2 Years
3 4
5 6
MM0-1
7 8
MM2
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
MM3
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
MM4
MM5
MM6
ANZCOTR 2013
ACTUARIAL SURVIVAL HLA DR LOCUS
MISMATCH ALL LUNGS 1986 -2013
100
80
p=ns
60
Percent
Survival
40
20
0
0
1
2
3
4
5
6
7
8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
MM0
MM1
MM2
Years
ANZCOTR 2013
Survival by Cutler-Ederer life tables, comparisons by log rank Cox-Mantel
ACTUARIAL SURVIVAL HLA DR LOCUS
MISMATCH LUNGS 1986 – 2013
Year
0
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
MM0
n=
62
52
45
41
35
30
27
24
18
15
15
14
13
13
11
8
6
5
4
3
3
2
1
1
%
100.0
86.9
78.4
76.6
68.9
66.8
62.3
55.4
48.0
42.5
42.5
42.5
39.5
39.5
33.4
33.4
28.9
24.1
24.1
24.1
24.1
24.1
24.1
24.1
MM1
n=
489
394
334
271
210
180
153
128
99
85
75
64
54
45
33
27
20
17
13
10
5
2
%
100.0
85.7
77.8
70.7
62.2
57.5
54.2
50.5
45.0
41.7
38.2
37.7
35.2
33.1
27.0
25.2
24.2
22.9
22.9
22.9
17.5
13.1
MM2
n=
1810
1484
1225
995
839
698
580
523
441
373
309
235
174
137
110
88
70
48
39
28
21
14
8
5
4
%
100.0
86.7
77.5
68.8
63.1
57.2
52.2
49.7
45.6
42.2
38.9
35.2
31.8
29.8
28.4
26.5
24.2
22.6
20.2
19.6
19.6
17.5
15.9
15.9
15.9
ANZCOTR 2013
CAUSE OF DEATH - ALL
LUNGS 1986 - 2012
ANZCOTR 2012
CAUSE OF DEATH - LUNGS 1986 - 2013
n = 1219
Bronchiolitis Obliterans
Infection
Pulmonary Failure
Other Malignancy
NSGF
Acute Rejection
Renal Failure
Hemorrage
PTLD
CVA
TxCAD
OTHER (incl unspec)
Totals
Multi-organ Failure
Cardiac Arrest (16) Heart Failure(5) IHD(4)
Sudden Death (cause unknown)
Post Surgical Complications
Suicide(4) Non compliance(4) Withdrawal of treatment(2) Inanition(1)
Bowel Ischemia(4) Perforation(1) Rupture(1)
Liver Failure(5) Cirrhosis(1)
Necrotising Bronchiolitis(3) BronchO Pneumonia(2)
Pulmonary Embolism (4)
Aspergillosis (3) Aspiration (1)
Pancreatitis
Hypoxic brain (2)
Pneumothorax(1)
Aortic Dissection
Esophageal rupture
Systemic vasculitis
Parkinson's disease
Metabolic problem
Reperfusion Injury
Dissecting Abdominal Aortic Aneurysm
Cyclosporin Neurotoxicity
Metabolic problem
Unspecified (no data)
27
25
12
11
9
6
6
5
4
4
4
2
1
1
1
1
1
1
1
1
1
1
23
403
33%
267
22%
94
8%
75
6%
70
5%
32
3%
39
3%
34
3%
26
2%
26
2%
6
1%
147
13%
1219
100%
ANZCOTR 2013
CAUSE OF DEATH ALL LUNGS < 5 YEARS POST TX
Bronchiolitis Obliterans
Infection
Misc
Pulmonary Failure
Non specific Graft Failure
Non Lymphoid Malignancy
Hemorrhage
Rejection
CVA
PTLD
Renal Failure
No Data
Graft Atherosclerosis (TxCAD)
No
269
209
93
70
63
30
29
28
25
18
17
6
5
%
31.2
24.2
10.8
8.1
7.3
3.5
3.4
3.2
2.9
2.1
2.0
0.7
0.6
Totals
862
100.0
CAUSE OF DEATH ALL LUNGS ≥ 5 YEARS POST TX
Bronchiolitis Obliterans
Infection
Non Lymphoid Malignancy
Misc
Pulmonary Failure
Renal Failure
PTLD
NonSpecific Graft Failure
No Data
Hemorrhage
Rejection
CVA
Graft Atherosclerosis (TxCAD)
No
134
57
45
42
24
22
8
7
6
5
4
2
1
%
37.5
16.0
12.6
11.8
6.7
6.2
2.2
2.0
1.7
1.4
1.1
0.6
0.3
Totals
357
100.0
ANZCOTR 2013