Light4LIFE
Germany the Center of Innovation
in the Area of
BioPhotonics
Michael Fedorov, MD, PhD
Moscow, 05.12.2014
Content
1.
2.
3.
4.
5.
6.
Optics & Photonics
BioPhotonics
Light4LIFE – Partners
OCT
Light4LIFE – Realization
Activities
Moscow – 05.12.2014
1.Optics & Photonics
• May 2000: German Agenda of the
Federal Ministry of Education and
Research (bmbf): »Optical
Technologies for the 21st Century«
•June 2001: Foundation of the 7
regional Competence Networks
for Optical Technologies as a
supporting measure of the
bmb+f
Moscow – 05.12.2014
1.Optics & Photonics
The 9 regional Networks of Competence in
OT
Moscow – 05.12.2014
1.Optics & Photonics
Production Volume in
Germany
Other states:
52%
BadenWuerttemberg
25%
Bavaria
23%
Source: OPTECH CONSULTING October 2007
 Almost 50% of the Production Volume in Optical Technologies
of Germany is located in Baden-Wuerttemberg and Bavaria.
Moscow – 05.12.2014
1.Optics & Photonics
Bavaria: Production Volume in OT
Production Volume in Bavaria [€]
> 500
million
Energy
Technology
100 - 500
million
< 100
million
Production
Technology,
Image Processing
& Metrology
Medical
Technology &
Life Science
Lighting
Technology
Optical
Components &
Systems
Information &
Communication
Technology
(Flat-)
Display Technology
< 10%
Moscow – 05.12.2014
10% – 19%
20% - 49%
> 50%
1.Optics & Photonics
Bavaria offers an excellent environment for OT:
• more than 400 manufacturing companies
• 9 universities and 17 universities of
applied sciences
• 8 research institutes in photonics
• 40 service provider (software, consulting,
etc.)
Moscow – 05.12.2014
1.Optics & Photonics
Thematic priorities:
Photonics in Industrial Production
Laser Materials Processing
Moscow – 05.12.2014
1.Optics & Photonics
Thematic priorities:
Micro- and Nano-Technology
Moscow – 05.12.2014
1.Optics & Photonics
Thematic priorities:
BioPhotonics, Medical and Life Science
Moscow – 05.12.2014
2.BioPhotonics
Thematic
priorities:
Clinical
biophotonics,
what is it?
BioPhotonics, Medical and Life Science
► Use of light sources and light detectors and photoactive drugs to
investigate or manipulate living nature
Moscow – 05.12.2014
2.BioPhotonics
Diagnosis
Methods
Endoscopy
Endomicroscopy
Fluorescence (w/o drugs)
Optical coherence tomography (OCT)
Confocal
Two-photon excitation
Diffuse optical imaging
Holography
Raman
Photoacoustics
Moscow – 05.12.2014
Therapy
Biostimulation
Photodynamic Therapy (drug)
Laser Surgery
2.BioPhotonics
Clinical Biophotonics ‐
Fluorescence and other optical techniques to support intraoperative
diagnostics
Localization
DOI
Fl. tomography
Staging
OCT
Photoacoustics
Grading
Confocal
Endoscopy
Molecular
target
Function
Moscow – 05.12.2014
2-Photon
Endoscopy
Fluorescence endoscopy
Lifetime
Raman
Fl. endoscopy
OCT
1. Partners
Moscow – 05.12.2014
1.1. Partner – Research
• R&D for clinical applications in
BioPhotonic
• German-Russian Networking in clinical
research. Scientific focuses: Photodynamic,
Biotechnology and BioPhotonic.
• Cooperates with research facilities and
hospitals from Russia for a long time
• Research activities in Germany and Russia
 Many contacts with Russia
Moscow – 05.12.2014
1.2. Partner – Industry
Main areas of activity:
German branch of the Thorlabs Inc.
~ 100 employees
• R&D, production of test & measurement equipment
• Technical Sales & Support of all catalogue products
• Logistic hub for other European Thorlabs entities
Spectral Domain-OCT technology:
• 4 standard products released to market
• Several projects in medical market segments
Moscow – 05.12.2014
1.3. Partner – Network
• Cluster for optical technologies
• German wide networking via
OptecNet Germany
• Strong international networking
• Experience in location marketing and public relations
• Support the organization of events and
exhibitions (e.g. Photonica Moscow and
LASER - World of Photonics / Munich)
Moscow – 05.12.2014
3.1. We realize…
… a concrete win-win project with mutual learning
in the area of clinical BioPhotonics
Technology: Optical Coherence Tomography (OCT)
Application: Medical
Partners: Light4LIFE –
Universities in RUS
Moscow – 05.12.2014
3.2. Optical Coherence Tomography
(OCT)
3D image OCT
OCT - principle
Moscow – 05.12.2014
normal eyeground
3.2. Optical Coherence Tomography
Intra-operative diagnostics
Aim is „optical biopsy“:
• Localization
• Staging
• Grading
Ultrasound-like images
Resolution: ca. 10 µm
Depth:
1-2 mm
Moscow – 05.12.2014
Normal bladder
Bladder cancer
3.2.1. OCT Example
OCT bladder
normal
Karl et al., J Endourol 2008
Nephrogenic adenoma
Moscow – 05.12.2014
3.2.2. OCT Example
normal
inflammation
Moscow – 05.12.2014
pT2G3
CIS
invasive SCC
3.2.2. OCT Example
OCT cervix
Clinical study with 120 pts:
Gallwas et al., Las Surg Med 2011
Moscow – 05.12.2014
positive
Sensitivity
Specificity
CIN 1 and above
97%
40%
CIN 2 and above
85%
62%
3.3. Partners in Russia
1. Moscow – Exhibition Photonica
2. Nizhny Novgorod – Center for BioPhotonics
3. Novosibirsk – Academy of medical sciences,
Center for research in physics
Moscow – 05.12.2014
Moscow – 05.12.2014