Data Access Pilot Project
(DAPP)
Mei-Hua Huang, DrPH
Sharon Stein Merkin, PhD
Core Directors: Gail Greendale, MD, Arun Karlamangla, PhD, MD
Teresa Seema, PhD
DAPP Faculty: Mei-Hua Huang, DrPH
Sharon Stein Merkin, PhD
Weijuan Han, MS
Funded by the Older Americans Independence Center (OAIC)
Why DAPP?
Why DAPP?
 Personal
Data Shopper
Tailor to your study needs
 How do you get your data?
 Guidance/advice
 Efficiency

Introductions to DAPP Faculty
 Mei-Hua
Huang, DrPH,
Nutritional Epidemiology
 Sharon
Stein Merkin, PhD,
Social Epidemiology
Study Implementation
Study
Hypothesis
Data
Study Design
Analysis
Publication
Example using Public DataNHANES
Is education associated with awareness,
treatment and control of hypertension?
STUDY DESIGN
DATA
• Potential overlap in the literature
• Cross sectional
• Obtain data
• Multiple waves?
• weighting/survey design issues
• Defining exposure and
outcome
unique to NHANES
• Analysis plan
Analysis
Publication
Example of Data Requiring Proposal
- SWAN
Study Hypothesis
Data
•
•
•
•
Study Design
Potential overlap
Request data access
Submit concept proposal
to publication committee
Analysis
Analysis
Abstract, poster and
manuscript submitted to
Time consuming:
minimum months
Publication
publication committee
Services of DAPP
Research guidance/consulting



Guidance in implementing study hypotheses
Identifying relevant datasets
Assistance with data access

Available online
•
•




Public data (e.g., NHANES)
Non-public (e.g., SWAN)
Request to Study PI (e.g., PEPI)
Guidance in navigating datasets
Contacts
Analysis services*
*Minimal, potential analyst time depending on funding
Dataset List
Study
Study Design
Study of Women's Health Across the Nation
(SWAN)
Longitudinal
cohort
Postmenopausal Estrogen/Progestin
Interventions (PEPI)
Clinical trial
Osteoporotic Fractures in Men (MrOS) Study
Longitudinal
cohort
Study of Osteoporotic Fractures (SOF)
Longitudinal
cohort
Rancho Bernardo Study
Longitudinal
cohort
Yoga Empowers Seniors Study (YESS)
Clinical trial
Yoga for Kyphosis Trial
Clinical trial
Dataset List
Study
Study Design
National Health and Nutrition Examination
Survey (NHANES)
Cross-sectional
Multiethnic Study of Atherosclerosis (MESA)
Longitudinal
cohort
Midlife in the United States (MIDUS)
Longitudinal
cohort
Coronary Artery Disease Risk Development in
Young Adults (CARDIA) Study
Longitudinal
cohort
Atherosclerosis Risk in Communities (ARIC)
Study
Longitudinal
cohort
Cardiovascular Health Study (CHS)
Longitudinal
cohort
Health and Retirement Study (HRS)
Longitudinal
cohort
MIDUS: Midlife in the United
States
Longitudinal cohort study
 Main objective: psychosocial, behavioral,
sociodemographic correlates with aging
 n=7108; ages 24-74 years

MIDUS 1: White (88%), AA (6%), Other (6%)
 MIDUS 2: White (80%), AA (15%), Other (5%)


2 visits

MIDUS 1: 1994-1995; MIDUS 2: 2005-2006 (including
new Milwaukee participants)
Recruited from across the U.S.
 Access: public, download from ICPSR website

MIDUS: Midlife in the United
States
Project 1
MIDUS 1
MIDUS II
n=7108
Phone/SAQ
Demographics,
Psychosocial, Medical
history
n=5555
Phone/SAQ
Demographics,
Psychosocial, Medical
history
Project 2
Daily Diary
n=2022
Project 3
Cognition
n=4518
Project 4
Biomarkers
n=1255
CHS: Cardiovascular Health
Study
 Longitudinal
cohort study
 Main objective: study determinants of
cardiovascular disease
 n=5888; ages 65+ years; White (81%) AA
(16%) Other (3%)
 10 exams
 Baseline:
1989; yearly follow-up through 1999.
 AA cohort initiated study in 1992
 Recruited
from 4 US communities
 Access: proposal and approval from CHS
CHS: Cardiovascular Health
Study
Base yr3
yr4
yr5
yr6
yr7
yr8
yr9
yr10 yr11
Self-rated
health
x
x
x
x
x
x
x
x
Education
x
Income
x
x
x
Depression
x
x
x
Phlebotomy
x
Nutrition
x
x
x
x
x
x
x
x
AA cohort
X
x
x
x
x
x
x
x
ARIC: Atherosclerosis Risk in
Communities
 Longitudinal
cohort study
 Main objective: investigate the cause of
atherosclerosis and its clinical outcomes
 n=15,792; ages 45-64 years; White (73%)
Non-White (27%) 5 visits
 Baseline:
1987-1989; Visit 2: 1990-1992; Visit
3: 1993-1995; Visit 4: 1996-1998; Visit 5:
2009-2011
 Recruited
from 4 US communities
 Access: proposal and approval from ARIC
ARIC: Atherosclerosis Risk in
Communities
CARDIA: Coronary Artery Risk
in Young Adults
Longitudinal cohort study
 Main objective: study determinants of subclinical
cardiovascular disease
 n=5115; ages 18-30 years; White (50%) AA
(50%)
 8 visits


Baseline: 1985-1986, Visit 2: 1987-88, Visit 3: 199091, Visit 4: 1992-93, Visit 5: 1995-96, Visit 6: 2000-01,
Visit 7: 2005-6, Visit 8: 2010-11
Recruited from 4 US communities
 Access: proposal and approval from CARDIA

CARDIA: Coronary Artery Risk
in Young Adults
MESA: Multi-Ethnic Study of
Atherosclerosis
Longitudinal cohort study
 Main objective: study determinants of subclinical
cardiovascular disease
 n=6814; ages 45-84 years; White (38%) AA
(28%) Chinese (12%) and Hispanic (22%)
 5 exams


Baseline: 2000-2002; Exam 2: 2002-2004; Exam 3:
2004-2005; Exam 4: 2005-2007; Exam 5: 2010-2012
Recruited from 6 US communities
 Access: proposal and approval from MESA

MESA: Multi-Ethnic Study of
Atherosclerosis
Personal/ Medical Hx/
Psychosocial
Exam 1
Exam 2
Exam 3
Exam 4
Exam 5
N=6814
N=6232
N=5939
N=5704
N=4651
X
X
X
X
X
X
A2500
Family Hx
X
Sleep Hx
X
Residential/neighborhood
X
Occupation/employment
X
X
X
Physical Activity
X
X
X
Food Frequency (Diet)
X
Anthropometry
X
X
X
X
X
Phlebotomy collection
X
X
X
X
X
Urine collection
X
X
X
Genotyping
Cognitive Function
X
X
X
X
X
Study of Women’s Health
Across the Nation (SWAN)
 Multi-center, multi-ethnic, community
based longitudinal study
 Characterize the biological, symptomatic,
and psychosocial changes that occur
during the MT
 Understand the effects of these changes on
women's health during and after the MT
SWAN Overview: Cohort
Eligibility



aged 42-52 years
at least 1 menstrual period in prior 3 mo
a member of each site's racial/ethnic group
Participants
3,302 women at 7 clinical sites





1550 Caucasian [all sites]
935 African American [Chicago, Pittsburgh, Boston,
Detroit]
286 Hispanic [NJ]
250 Chinese [Davis]
281 Japanese [LA]
SWAN Overview: Data
Collection Schedule
SWAN Ancillary Studies
Fat Patterning (Diabetes Risk)
 Functional Status
 Hip Strength
 Mammographic Density
 Mental Health
 Phytoestrogens
 Sleep
 Subclincial Atherosclerosis (SWAN Heart)

How to get started using DAPP
 Contact
:
Dr. Huang (mhuang@mednet.ucla.edu) or
Dr. Merkin (smerkin@mednet.ucla.edu)
 Dataset
Information
http://geronet.ucla.edu/dapp
 Complete
a pre-consultation survey