Treatments for Mood Disorders

Treatments for Mood Disorders

Mood disorders – as extraordinarily painful and disabling as they tend to be – respond more successfully to more kinds of treatments than do most other forms of psychological dysfunction

This diversity of successful treatments has affected individuals with depression in both positive and negative ways

Treatments for Unipolar Depression

Approximately one-third of people with unipolar depression (major depressive or dysthymic disorder) enter treatment in a given year

In addition, many other people in therapy experience depressed feelings as part of another disorder – thus, much of the therapy being administered today is for unipolar depression

Treatments for Unipolar Depression

A variety of treatment approaches are in widespread use

These can be divided into various models
 psychological,

Sociocultural
 biological

Treatments for Unipolar Depression:
Psychological Approaches

Psychological approaches to treating unipolar depression come from the three main models:

Psychodynamic – Until recently, was widely used despite no strong research evidence of its effectiveness

Behavioral – Primarily used for mild or moderate depression but practiced less than in past decades

Cognitive – Has performed so well in research that it has a large and growing clinical following

Treatments for Unipolar Depression:
Psychological Approaches

Psychodynamic therapy

Believing that unipolar depression results from unconscious grief over real or imagined losses, compounded by excessive dependence on other people, psychodynamic therapists seek to bring these issues into consciousness and work through them

Psychodynamic therapists use the same basic procedures for all psychological disorders:

Free association

Therapist interpretation

Treatments for Unipolar Depression:
Psychological Approaches

Psychodynamic therapy

Despite successful case reports, researchers have found that long-term psychodynamic therapy is only occasionally helpful in cases of unipolar depression


Two features may be particularly limiting:

Depressed clients may be too passive or weary to fully participate in clinical discussions

Depressed clients may become discouraged and end treatment too early when treatment doesn’t provide fast relief
Short-term approaches have performed better than traditional approaches

Treatments for Unipolar Depression:
Psychological Approaches

Behavioral therapy

Lewinsohn, whose theory tied a person’s mood to his/her life rewards, developed a behavioral therapy for unipolar depression in the 1970s:

Reintroduce clients to pleasurable activities and events, often using a weekly schedule

Appropriately reinforce their depressive and nondepressive behaviors

Use a contingency management approach

Help them improve their social skills

Treatments for Unipolar Depression:
Psychological Approaches

Behavioral therapy

The behavioral techniques seem to be of only limited help when just one of them is applied

When treatment programs combine two or three of the techniques, as Lewinsohn had envisioned, depressive symptoms (especially mild symptoms) seem to be reduced

Treatments for Unipolar Depression:
Psychological Approaches

Cognitive therapy

Beck views unipolar depression as resulting from a pattern of negative thinking that may be triggered by current upsetting situations

Maladaptive attitudes lead people to the “cognitive triad”

Negatively viewing oneself, the world, and the future

These biased views combine with illogical thinking to produce automatic thoughts

Treatments for Unipolar Depression:
Psychological Approaches




Cognitive therapy
Beck’s cognitive therapy – the leading cognitive treatment for unipolar depression – is designed to help clients recognize and change their negative cognitive processes
This approach follows four phases and usually lasts fewer than 20 sessions
1.
2.
3.
4.
Phases:
Increasing activities and elevate mood
Challenging automatic thoughts
Identifying negative thinking and biases
Changing primary attitudes

Treatments for Unipolar Depression:
Psychological Approaches

Cognitive therapy

Over the past three decades, hundreds of studies have shown that cognitive therapy helps unipolar depression

Around 50% – 60% of clients show a near-total elimination of symptoms

This treatment has also been used in a group therapy format


Cognitive Therapy
Phase 1: Increasing activities and elevating moods

Cognitive-behavioral approach

Therapists encourage clients to become more active and confident

Prepare a detailed schedule of hourly activities for the coming week

Increased activity is expected to elevate the patient’s mood
WHY???

Cognitive Behavioral models of dep.
A variety of models focused on the consequences of thought processes
Beck - believes that two mechanisms produce dep.
A. Fundamental flaws in self-beliefs
1. The cognitive triad
• negative thoughts about self, ongoing experience, the future
2. depressives have the belief that they are defective, worthless, inadequate.

3. beliefs of defectiveness --> low self-esteem (will never gain happiness.
4. neutral information from others is misinterpreted as meaning defeat or worthlessness, drawn to the worst case scenario, small obstacles become barriers.

B. Errors in logic - the depressive makes some of these errors in logical thinking
1. Arbitrary inference - draws a conclusion when there is little or no information to support it.
2. Selective abstraction - focusing on one insignificant detail while ignoring the more important features of a situation.
3. Overgeneralization - drawing global conclusions about worth, performance or ability on the basis of a single fact or event.

4. Magnification and minimization - gross errors of evaluation, small bad events are magnified and large good events are minimized.
5. Personalization - incorrectly taking responsibility for bad events in the world.
Repeated, automatic errors such as these often lead to depression

Treatments for Unipolar Depression:
Sociocultural Approaches

Theorists trace the causes of unipolar depression to the broader social structure in which people live, and the roles they are required to play

The most effective sociocultural approaches to treating unipolar depression are interpersonal psychotherapy and couple therapy

The techniques used in these approaches borrow from other models

Treatments for Unipolar Depression:
Sociocultural Approaches

Interpersonal therapy (IPT)

This model holds that four interpersonal problems may lead to depression and must be addressed:

Interpersonal loss

Interpersonal role dispute

Interpersonal role transition

Interpersonal deficits

Studies suggest that IPT is as effective as cognitive therapy for treating depression

Treatments for Unipolar Depression:
Sociocultural Approaches

Couple therapy

The main type of couple therapy is behavioral marital therapy (BMT)

Focus is on developing specific communication and problemsolving skills

If marriage is conflictual, BMT is as effective as other therapies for reducing depression

Treatments for Unipolar Depression:
Biological Approaches

Biological treatments can bring great relief to people with unipolar depression

Usually biological treatment means antidepressant drugs, but for severely depressed persons who do not respond to other forms of treatment, it sometimes includes electroconvulsive therapy

Treatments for Unipolar Depression:
Biological Approaches

Electroconvulsive therapy (ECT)

The use of ECT was -- and is -- controversial

It is now used frequently but only in severe cases

The procedure consists of targeted electrical stimulation to cause a brain seizure

The usual course of treatment is 6 to 12 sessions spaced over two to four weeks

Treatment may be bilateral or unilateral

Treatments for Unipolar Depression:
Biological Approaches

Electroconvulsive therapy (ECT)

The discovery of the effectiveness of ECT was accidental and based on a fallacious link between psychosis and epilepsy

The procedure has been modified in recent years to reduce some of the negative effects

For example, patients are given muscle relaxants and anesthetics before and during the procedure

Patients generally report some memory loss

Treatments for Unipolar Depression:
Biological Approaches

Electroconvulsive therapy (ECT)

ECT is clearly effective in treating unipolar depression

Studies find improvement in 60% – 70% of patients

The procedure seems particularly effective in cases of severe depression with delusions, but it has been difficult to determine why ECT works so well

Although effective, the use of ECT has declined since the
1950s, because of the memory loss caused by the procedure and the emergence of effective antidepressant drugs

Treatments for Unipolar Depression:
Biological Approaches

Antidepressant drugs

In the 1950s, two kinds of drugs were found to be effective:

Monoamine oxidase inhibitors (MAO inhibitors)

Tricyclics

These drugs have been joined in recent years by a third group, the second-generation antidepressants, SSRI’s

Treatments for Unipolar Depression:
Biological Approaches

Antidepressant drugs: MAO inhibitors

Originally used to treat TB, doctors noticed that the medication seemed to make patients happier

The drug works biochemically by slowing down the body’s production of MAO

MAO breaks down norepinephrine

MAO inhibitors stop this breakdown from occurring

This leads to a rise in norepinephrine activity and a reduction in depressive symptoms

About half of patients who take these drugs are helped by them

Treatments for Unipolar Depression:
Biological Approaches

Antidepressant drugs: MAO inhibitors

MAO inhibitors potentially pose a serious danger!

Blood pressure may rise to a potentially fatal level if one eats foods with tyramine (cheese, bananas, wine) while taking MAOIs

In recent years, a new MAO inhibitor in the form of a skin patch has become available

Dangerous food interactions do not appear to be as common a problem with this kind of MAO inhibitor

Treatments for Unipolar Depression:
Biological Approaches

Antidepressant drugs: Tricyclics

In searching for medications for schizophrenia, researchers discovered that imipramine lessened depressive symptoms

Imipramine and related drugs are known as tricyclics because they share a three-ring molecular structure

Treatments for Unipolar Depression:
Biological Approaches

Antidepressant drugs: Tricyclics

Hundreds of studies have found that depressed patients taking tricyclics have improved much more than similar patients taking placebos

Drugs must be taken for at least 10 days before such improvement is seen

About 60% – 65% of patients find symptom improvement

Treatments for Unipolar Depression:
Biological Approaches

Antidepressant drugs: Tricyclics

Most patients who immediately stop taking tricyclics upon relief of symptoms relapse within one year

Patients who take tricyclics for five additional months
(“continuation therapy”) have a significantly decreased risk of relapse

Patients who take antidepressant drugs for three or more years after initial improvement (“maintenance therapy”) may reduce the risk of relapse even more

Treatments for Unipolar Depression:
Biological Approaches

Antidepressant drugs: Tricyclics

Tricyclics are believed to reduce depression by affecting neurotransmitter (NT) reuptake

To prevent an NT from remaining in the synapse too long, a pumplike mechanism recaptures the NT and draws it back into the presynaptic neuron

The reuptake process appears to be too effective in some people, drawing in too much of the NT from the synapse

This reduction in NT activity in the synapse is thought to result in clinical depression

Tricyclics block the reuptake process, thus increasing NT activity in the synapse

Treatments for Unipolar Depression:
Biological Approaches

Antidepressant drugs: Tricyclics

There is growing evidence that when tricyclics are ingested, they initially slow down the activity of the neurons that use norepinephrine and serotonin

After a week or two, the neurons adapt to the drugs and go back to releasing normal amounts of the NTs

Today tricyclics are prescribed more often than MAO inhibitors

They do not require dietary restrictions

Some patients show higher rates of improvement

Treatments for Unipolar Depression:
Biological Approaches

Second-generation antidepressant drugs

A third group of effective antidepressant drugs is structurally different from the MAO inhibitors and tricyclics

Most of the drugs in this group are labeled selective serotonin reuptake inhibitors (SSRIs)

These drugs act only on serotonin (no other NTs are affected)

This class includes fluoxetine (Prozac) and sertraline (Zoloft)

Selective norepinephrine reuptake inhibitors and serotoninnorepinephrine reuptake inhibitors are also now available

Treatments for Unipolar Depression:
Biological Approaches

Second-generation antidepressant drugs

The effectiveness and speed of action of these drugs is on par with the tricyclics yet they boast enormous sales

Clinicians often prefer these drugs because it is harder to overdose on them than on other kinds of antidepressants

There are no dietary restrictions like there are with MAO inhibitors

There have fewer side effects than the tricyclics

These drugs may cause some undesired effects of their own, including a reduction in sex drive

How Do the Treatments for
Unipolar Depression Compare?

For most kinds of psychological disorders, no more than one or two treatments, if any, emerge as successful

Unipolar depression seems to be the exception, responding to any of several approaches

How Do the Treatments for
Unipolar Depression Compare?

Findings from a number of research studies suggest that:

Cognitive, interpersonal, and biological therapies are all highly effective treatments for mild to severe unipolar depression

Although cognitive and interpersonal therapies may lower the likelihood of relapse, they are hardly relapseproof

How Do the Treatments for
Unipolar Depression Compare?

Findings from a number of research studies suggest that:

When persons with unipolar depression experience significant marital discord, couple therapy tends to be very helpful

Depressed people who receive strictly behavioral therapy have shown less improvement than those who receive cognitive, interpersonal, or biological therapy

How Do the Treatments for
Unipolar Depression Compare?

Findings from a number of research studies suggest that:

Psychodynamic therapies are less effective than other therapies in treating all levels of unipolar depression

A combination of psychotherapy and drug therapy is modestly more helpful to depressed people than either treatment alone

How Do the Treatments for
Unipolar Depression Compare?

Findings from a number of research studies suggest that:

Among biological treatments, antidepressant drugs and ECT appear to be equally effective for reducing depression, although ECT seems to act more quickly

Treatments for Bipolar Disorders

Until the latter part of the 20 th century, people with bipolar disorders were destined to spend their lives on an emotional roller coaster

Psychotherapists reported almost no success

Antidepressant drugs were of limited help

These drugs sometimes triggered manic episodes

ECT only occasionally relieved either the depressive or the manic episodes of bipolar disorder

Treatments for Bipolar Disorders:
Lithium Therapy

The use of lithium, a metallic element occurring as mineral salt, has dramatically changed this picture

It is extraordinarily effective in treating bipolar disorders and mania

Determining the correct dosage for a given patient is a delicate process

Too low = no effect

Too high = lithium intoxication (poisoning)

Treatments for Bipolar Disorder:
Lithium Therapy

Lithium provides improvement for more than
60% of manic patients

Most patients also experience fewer new episodes while on the drug

Lithium also is a prophylactic drug, one that actually prevents symptoms from developing

Lithium also helps those with bipolar disorder overcome their depressive episodes

Treatments for Bipolar Disorder:
Lithium Therapy

Researchers do not fully understand how lithium operates

They suspect that it changes synaptic activity in neurons, but in a different way from that of antidepressant drugs

Although antidepressant drugs affect a neuron’s initial reception on
NTs, lithium seems to affect a neuron’s second messengers

Another theory is that lithium corrects bipolar functioning by directly changing sodium and potassium ion activity in neurons

Treatments for Bipolar Disorder:
Adjunctive Psychotherapy

Psychotherapy alone is rarely helpful for persons with bipolar disorder

Lithium therapy alone is also not always sufficient, either

30% or more of patients don’t respond, may not receive the correct dose, or may relapse while taking it

As a result, clinicians often use psychotherapy as an adjunct to lithium (or other medication-based) therapy

Treatments for Bipolar Disorder:
Adjunctive Psychotherapy

Therapy focuses on medication management, social skills, and relationship issues

Few controlled studies have tested the effectiveness of such adjunctive therapy

Growing research suggests that it helps reduce hospitalization, improves social functioning, and increases clients’ ability to obtain and hold a job