NATURAL PRODUCTS RESEARCH
CHEMISTRY DEPARTMENT,
MAKERERE UNIVERSITY
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MAJOR RUNNING THEME SINCE 1998
BIOPROSPECTING FOR FLAVONOIDS IN UGANDAN
FLORA
Main collaborator: Prof. Øyvind Andersen
University of Bergen,Norway
The focus has been guided by the following questions:
•Have plants been used locally for medicinal purposes?
•Have plants been researched for flavonoid content before?
•Are the flavonoids observed in a preliminary screening new
compounds or not?
•Are the plants or plant parts edible
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Current Research Team
• Prof. Bernard T. Kiremire
• Assoc. Prof. Robert Byamukama
• Dr. Hannington Twinomuhwezi-Busitema
University
• Ms. Jane Namukobe
• Ms. Adia Madina
• Mr. Christopher Adaku-Mbarara University
• Collaborators: National and International to be
detailed later
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On Going Projects in natural products
2013
1. Bioprospecting For Flavonoids In
Ugandan Flora
2.
Multi-disciplinary University Traditional
Health Initiative (MUTHI): Building
Sustainable Research Capacity on Plants for
Better Public Health in Africa
• Researchers:
• Bernard. T. Kiremire, Robert Byamukama, Grace
Nambatya,Jane Namukobe, Adia Madina, Christopher
Adaku
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On Going Projects in natural products
2013 -continued
Collaborators
University of Oslo: Prof. Berit Paulsen, Over all
coordinator, Mr. Jørgen Kirksæther [Finance admin]
University of Bergen:Prof. Øyvind Andersen
University of Mali: Prof. Drissa Diallo
Joop deJong; Mrs Charlotte van’t Klooster
Oxford University: Prof.Gerry Bodeker,Dr. Merlin
Willcox,
University of Western Cape: Prof.Gail Hughes,
University of orange Free state:
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France-Uganda Research cooperation (FURC)
project on plant Phytochemistry
• Researchers: Bernard. T. Kiremire, Robert Byamukama, Jane
Namukobe
• Collaborators
• John.M. Kasenene :Mountain of the Moon University
• Françoise Guéritte: Institut de Chimie des Substances Naturelles,
France
• Vincent Dumontet : Institut de Chimie des Substances Naturelles,
France
• Sabrina Krief : Eco-Anthropologie et Ethnobiologie,France
• Isabelle Florent :National Museum Natural History,France
• John D. Kabasa : College of Veterinary Medicine, animal resources
and biosecurity, Makerere university :
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PhD based studies
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Isolation and Characterization of Anti-Bacterial
Constituents of Maytenus Putterlickioides, Vernonia
Glabra and Thalictrum Rhychocarpum
PhD student
Mayeku Philip Wafula
Supervisor/collaborators
• Prof. Bernard Kiremire, Makerere University
• Prof. Abiy Yenesew, University of Nairobi,Kenya
• Dr. Josiah Odalo, Jomo Kenyatta University
Achievements so far
• 2 Publications in International Journals
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Phytochemical investigation of selected plants
from the family Asphodelaceae for AntiInfective principles:
PhD student
Induli Martha
Supervisor/collaborators
• Assoc. Prof. Byamukama Robert, Makerere
University
• Prof. Abiy Yenesew, University of Nairobi, Kenya
Achievements so far
• 2 Publications in International Journals
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Phytochemical and Antiplasmodial
Studies of Neoboutonia Macrocalyx L.
PhD student
• Jane Namukobe, Makerere University
Supervisors
• Assoc. Prof. Byamukama Robert, Makerere
University
• Prof. Kiremire Bernard, Makerere University
Achievements so far
• 2 Publications in International Journal
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Nutraceutical Potential of Some Ugandan
Plants with Focus on Anthocyanins
PhD student
• Christopher Adaku
Supervisor/collaborators
• Assoc. Prof. Byamukama Robert, Makerere
University
• Prof. Kiremire Bernard, Makerere University
• Prof. Øyvind Andersen,University of Bergen
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Phytochemistry of selected herbal remedies used
by traditional herbalists in treatment of malaria
in Uganda
PhD student
• Adia Madina, Makerere University
(MUTHI)
Supervisor/collaborators
• Assoc. Prof. Byamukama Robert, Makerere
University
• Prof. Kiremire Bernard, Makerere University
• PROMETRA Uganda-Association of herbalists
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COMPLETED PROJECTS
Characterization of anthocyanins from Selected
Plants in Uganda
PhD Candidate
• Byamukama Robert, Makerere University, PhD
Thesis, currently teaching at Makerere University.
Out put
4 Publications in International Journal
Thesis Publication at Makerere University
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COMPLETED PROJECTS
Characterization and Analysis of Some Natural
Dyes from Selected Plants in Uganda.
Researcher
• Wanyama Aaron Philip Guloba,
Achievements
• PhD Thesis published at Makerere University.
• 5 Publications in International journals
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COMPLETED PROJECTS
Phytochemical Investigation of Erythrina
Abyssinica, Erythrina Burttii, Erythrina
Melanacantha And Derris Trifoliata: Towards
Malaria Control.
Researcher
Twinomuhwezi Hannington
Achievements
• PhD Thesis published at Makerere University.
• 3 Publications in International journals
• Lecturership at Busitema University.
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COMPLETED PROJECTS
• Antimalarial Activities Of Some Flavonoids And
Flavonoid-Rich Plant Extracts
Researcher
• Akala Miima Hoseah
Achievements
• PhD Thesis published at Makerere University.
• 3 Publications in International journals
• currently working at Kenya Medical Research
Institute[KEMRI]
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COMPLETED PROJECTS
Capacity building
• 14 MSc graduates working on natural products
areas (medicinal and flavonoids).
• 4 PhD graduates working on natural products
• 32 publications in International journals
MoUs developed
• MoU with PROMETRA Uganda, process completed
• MoU with MUMETHA, on-going
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CONTRIBUTION
Capacity building in terms human resource
• several graduates from Natural products
• Completed: 4PhDs, 14MSc
• Ongoing: 5PhDs, 3MSc
Contribution to science knowledge/flavoinoid
chemistry
• 30 novel compounds have been characterized together
with several known compounds.
• HPLC, GC-MS, Small equipments for isolation of natural
products.
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FUTURE PROJECTS
• Improvement of Selected Anti-malarial Herbal
Medicines Through Identification of Bioactive
Compounds and Development of Standardised
Formulation Methods
• Development of Antioxidants and Flavonoids as food
supplements from indigenous plant sources
• The Potential of Natural Dyes from Selected
Indigenous Dye-Yielding Plants as Substitutes for
Synthetic Dyes.
• Pesticide properties of Plants and Their Potential in
Crop Disease Control
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SIDA phase IV
• Concept was submitted based on the four topics in
our future projects
• PI on the concept is Assoc. Prof. whom Prof.
Kiremire has mentored through the previous
Projects
Required assistance.
• possible collaborators from SWEDEN on the above
areas of natural products
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CHALLENGES
FUNDING
• Lack of local funding from University or Government,
and this sometimes creates discontinuity when the
project ends and you have no other project.
EQUIPMENT
• Research funding usually not enough to buy big
equipment vital in Natural products research such as
MS and NMR.
• Much reliance on collaboration in order to use large
equipments.
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ACKNOWLEDGEMENTS
•
•
•
•
NUFU
SIDA
University of Bergen
Makerere university
Thank you for listening
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