National Institute of Chemistry
Ljubljana, 14th March 2014
Presentation of successful Marie Curie projects
FP7–PEOPLE–2009–IEF
FP7–PEOPLE–2012–CIG
Robert Vianello
Division of Organic Chemistry and Biochemistry
Ruđer Bošković Institute, Zagreb, Croatia
robert.vianello@irb.hr
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
• 60.000 Marie Curie fellows since the
launch of the Action in 1996
• over 10.000 doctorates supported
• Marie Curie fellows originate from all
over the World (130 nationalities)
• host institutions in Marie Curie actions
are located in more than 70 countries
• 46% researchers remain in Europe after
IIF Marie Curie fellowships
• women participation in Marie Curie
actions equals 38% (close to desired 40%)
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Marie Skłodowska-Curie Actions
excellent researchers’ training and
mobility for career development
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Number of projects in Marie Curie actions (2007–2012)
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Intra-European Fellowships (IEF) - FACTS
• Budget: 95.000.000 EUR (2009)
134.000.000 EUR (2013)
• Highly competitive
Category of researchers
EUR per year (2009)
EUR per year (2013)
< 4 years of experience
35.300
38.000
4–10 years of experience
54.300
58.500
> 10 years of experience
81.400
87.500
• 2008: 75.000.000 EUR for around 440 fellowships / 1.763 applications (25.0%)
• Basic documents:
Guide for Applicants (65 pages) (83 pages)
PEOPLE 2009 Work Programme (52 pages) (70 pages)
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Personal motifs to apply
• Quality of the fellowship
- enables high–quality scientific work
- promotes acquisition of new competencies (Career Development)
• Assure financing after the termination of the domestic UKF grant
- 3A project (“My first research grant”) 01/09/2008 – 31/08/2010
- “Computational Prediction of Structure and Catalytic Activity
of New Organic Superacids”
- co-financed by the industrial partner APO Ltd. Zagreb
• Many years of acquaintance with the host scientist and the host institution
- 3 bilateral Croatian–Slovenian projects, 1 joint scientific paper
• Close vicinity to Zagreb
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Host institution
National Institute of Chemistry
• Founded in the year 1946
- leading reasearch institute in Slovenia in the field of chemistry and related sciences
- independent, non–profit, public research institute
- 273 employees (31/12/2009), of which around 243 carry out research work (114 with
doctorates) in 15 laboratories and 2 infrastructure centers
• Research on structure, properties and function of biologically relevant systems
- Laboratory for Biosynthesis and Biotransformation / Laboratory of Biomolecular
Structure (vibrational spectroscopy) / Slovenian NMR centre
- Laboratory for Biocomputing and Bioinformatics / Laboratory for molecular modeling /
Laboratory of chemometrics
• Publish around 200 scientific papers annually
- average 2007 Impact Factor = 2.7
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Host institution
National Institute of Chemistry
• Diverse network of partners from the industry
- Krka, Lek, Helios, Belinka, Renault, Kolpa, Dior, BASF
- 20% of the annual income of the institute
• Branched network of international collaborations
- bilateral projects (30–35 / year): EU, USA, Japan...
- multilateral projects (20–25 / year): Joule, Phare, Tempus, Eureka, COST...
- 15 FP5 projects
- 14 FP6 projects
- total financial value of all FP5 and FP6 projects: 5.000.000 EUR
• Adequate infrastructure
- VRANA (eng. crow) cluster of PC computers with 772 processors (2008)
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Host scientist
Dr. Janez Mavri
• Senior research associate and a leader of the Laboratory for Biocomputing and
Bioinformatics, and Associate professor at the Faculty of Pharmacy in Ljubljana
• Research interests: dynamics of enzyme reactions, investigation of systems
connected through hydrogen bonds, chemical reactivity in solutions
• Published 68 scientific papers and 7 book chapters
- total number of citations = 766; Hirsch index = 16 (08/2009)
- plenary lecture at the Gordon conference “Isotopes in Biology and Chemistry” (Ventura,
California, USA; 2006)
- 2 invited lectures and more than 70 oral presentations at international conferences and
foreign universities
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Host scientist
Dr. Janez Mavri
• Guest Professor at the Franche–Comte University (Besancon, France) 2003.
- “Biomolecular simulations” at undergraduate level
• French Long Term Human Frontier Science Program Fellowship (University of
Groningen, Netherlands) 1993–1995
• Senior Fulbright Scholarship (University Southern California, USA) 2004
• In the last 3 years: mentor of 3 undergraduate and 3 postgraduate students
• In the last 3 years: mentor of 2 postdoctorate students during a 1 year stay at NIC
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Project application
• Topics of research were chosen by the host–scientist taking into account
competencies and interests of the fellow
• The host–scientist helped choosing references for the proposal writing
• Formal parts of the application are trivial (Part A)
• Research project is much more serious (Part B)
- take particular care about every detail written in the Guide for Applicants
• We did not select any reviewers for our proposal
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Contents and goals of the project
Computational Studies of Proton Dynamics in
Hydrogen Bonded Systems and Enzymes (CoSProDyn)
• Improve understanding of the biocatalysis and receptor triggering by
studying quantum nature of proton in proteins
• Research will be oriented towards 3 biological systems using state–
of–the–art methods of the computational biochemistry
• duration of the project: 18 months
• total financial value: 99.127,60 €
• beginning date: 1st October 2010
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Structure of the project application (Part B)
maximum 8 pages
maximum 2 pages
maximum 7 pages
maximum 6 pages
maximum 4 pages
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Structure of the project application (Part B) – HORIZON 2020
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Chronology of events
08/2009
18/08/2009
Registration to EPSS online system
Application submitted through EPSS online system
The number IEF–255038 was awarded
20/08/2009
Formal Acknowledgement of Receipt received
25/11/2009
Evaluation Summary Report received
Total number of applications:
Number of proposals above thresholds:
Budget:
Requested funds:
2.398
1.857
(77.4 %)
95.000.000,00 €
323.922.519,80 € (340,9 %)
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Evaluation Summary Report
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Evaluation Summary Report
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Evaluation Summary Report
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Evaluation Summary Report
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Chronology of events
08/2009
18/08/2009
Registration to EPSS online system
Application submitted through EPSS online system
The number IEF–255038 was awarded
20/08/2009
Formal Acknowledgement of Receipt received
25/11/2009
Evaluation Summary Report received
22/12/2009
Invitation to Negotiate received
A category:
B category:
C category:
D category:
E category:
575 (24.0 %)
174 (7.3 %)
1.108 (46.2 %)
531 (22.1 %)
0
(0.0 %)
Total number of applications: 2.398
Number of withdrawn projects: 10 (0.4 %)
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Reminder
(240.500.000 €)
H2020-MSCA-IF-2014
12.03.2014.
11.09.2014.
17:00:00 Brussels time
www.NEWFELPRO.hr
Publication of call
Deadline for submission of proposals
03.10.2014.
31.12.2014.
16:00 CET
end of December 2014
Evaluation Summary Reports
end of March 2015
January 2015
Invitation to Negotiate
April 2015
from March 2015
Signature of first Grant Agreements
From May 2015
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Contents and goals of the project (FP7–PEOPLE–2012–CIG)
Computational Studies of the Biogenic Amines of the Brain
for Targeting Neurological Diseases (CompBAND)
• Improve the understanding of a relation between features, metabolic pathways
and signal transduction of amine neurotransmitters and the treatment of
neurological diseases
• Research will be oriented towards 2 biological systems using state–of–the–art
methods of the computational biochemistry
• duration of the project: 48 months
• total financial value: 100.000 EUR
• beginning date: 1st April 2013
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Evaluation Summary Report
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Evaluation Summary Report
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Evaluation Summary Report
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Dopamine synthesis and metabolism by monoamine oxidase enzymes (MAOs)
reproduced from: MBH Youdim, DE Edmondson, KF Tipton, Nature Rev Neurosci 2006, 7, 295.
Patients with neurological diseases:
• Increased level of MAO activity
• Concentrations of dopamine close to zero
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
R Borštnar, M Repič, M Kržan, J Mavri, R Vianello
Eur J Org Chem 2011, 6419–6433.
R Vianello, M Repič, J Mavri
Eur J Org Chem 2012, 7057–7065.
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
50.000th Marie Curie Fellowship Award
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
"EU FP7 People Specific Programme Success Stories Booklet"
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Official site of the European Commission (www.croatia-in-the-eu.eu)
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
http://ec.europa.eu/programmes/horizon2020/
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
FP7 Marie Curie Actions
Intra-European Fellowships for career development (IEF)
At various stages of their career, experienced researchers may welcome an opportunity to acquire new research skills or
experience working in other sectors. Marie Curie Intra-European Fellowships for Career Development specifically aim at
helping experienced researchers to try something new for a while.
Who can apply?
Researchers can be of any nationality but as a general rule must move from one Member State or Associated country to
another in order to carry out the project. You must have either a doctoral degree or at least 4 years’ full-time equivalent
research experience, after obtaining a degree permitting you to embark on a doctorate.
What does the funding cover?
Financial support is provided for a period of 12-24 months (full-time equivalent), for individual projects presented by
experienced researchers from Member States or Associated Countries in liaison with a host organisation from a
Member State or Associated Country.
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
Ruđer Bošković Institute
National Institute of Chemistry
Ljubljana, 14th March 2014
National Institute of Chemistry
Janez Mavri
Meta Skumavc
Marijana Novič
Marjetka Podobnik
Rada Drnovšek
Radojka Verčko, PEOPLE NCP, Slovenia
Office for international projects, RBI
Renata Slovinić
Ines Ječmenjak
Marijana Klasnić–Kožar
Vesna Kotarski
Višnja Petera
Suzana Karabaić, PEOPLE NCP, Croatia
Ruđer Bošković Institute