INHALATION EXPOSURE LABORATORY
EUGENE APPLEBAUM COLLEGE OF
PHARMACY AND HEALTH SCIENCES
WAYNE STATE UNIVERSITY
CONTACT INFORMATION:
DEEPAK BHALLA, PH.D., PROFESSOR
PHONE: 577-3980
EMAIL: AD6268@WAYNE.EDU
VANITHA BHOOPALAN, M.S., RESEARCH ASSISTANT
PHONE: 577-3914
EMAIL: DY8663@WAYNE.EDU
RESEARCH TOPICS
NANOPARTICLE TOXICITY
NANOPARTICLE INTERACTION WITH OTHER
INHALED POLLUTANTS:
IN VIVO & IN VITRO
DRUG DELIVERY:
VOLUME MAY BE A LIMITING FACTOR
ALTERNATIVE – INTRATRACHEAL APPLICATION
THERAPEUTIC VALUE OF ANTIBODY-CONJUGATED
NANOPARTICLES
OZONE
EXPOSURE
EXHAUST
DASIBI
AIR
HYGROMETER
AIR DRYER
TEMPERATURE
HUMIDITY
SAMPLING
MODULE
PURAFIL
AIR
ACTIVATED
CHARCOAL
OZONE
CONC.
OZONE
FILTER
SYSTEM
NOSE-ONLY
CHAMBERS
PARTICLE
FILTER
FL
O
W
M
ET
E
R
HUMIDIFIER
FL
O
W
M
ET
E
R
OZONIZER
PARTICLE
FILTER
O
X
Y
G
E
N
OZONE EXPOSURE SYSTEM
(NOSE-ONLY)
CHAMBERS FOR NOSE-ONLY
EXPOSURE TO OZONE
OZONE, HUMIDITY AND TEMPERATURE MONITORS
SMOKE EXPOSURE
WALTON’S SMOKE MACHINE
SMOKE IN MIXING CHAMBER
(2 SEC. PUFF)
HEAVY SMOKE IN MIXING CHAMBER
CIGARETTE SMOKE
WHOLE-BODY EXPOSURE
CHAMBER
FILTERED
CIGARETTE
NON - FILTERED CIGARETTE
SCIREQ SMOKE MACHINE
COMPUTER CONTROLLED SMOKING
SMOKING REGIMEN
1) Two second standard puff
2) A period of high flow during which the smoke is
pushed downstream towards the animals.
3) A period of high flow during which the smoke is
cleared out prior to the next puff.
(1) (2)
Room Air
Smoke
(3)
CIGARETTE SMOKE CONDENSATE
(24.9mg/ml; 5/26/2011)