Toxoplasma Gondii
Classification toxoplasma gondii
Phylum :- Protozoa
Class :- Sporozoa
Order :- Eimeriina
Family :- Toxoplasmatidae
Genus :- Toxoplasma gondii
Introduction 
Toxoplasma gondii is an intestinal
coccidium that parasitizes
members of the cat family as
definitive hosts and has a wide
range of intermediate hosts.
Infection is common in many
warm-blooded animals, including
humans. In most cases infection is
asymptomatic, but devastating
disease can occur.

Morphology and life cycle
1-Trophozoite :2- Cyst
:-
3- Oocyst
:4- Schizonte :5- Gametogenic:-
In Intermediate hosts
In Definitive hosts
FIGURE -1- Trophozoite
FIGURE -2- Sexual states of Tgondii
Figure-3- Toxoplasma gondii is transmitted.
Cysts ingested by cat
Oocyst in feces
In feces
Sporoblast
sporocyst
Sporozoites
oocust
Development
Mutureoocyst
Zygote
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Reproduction (endodyogeny)
‫مضيف وسطي‬
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♂♀
Development
Tropho
Ingested by cat or any animals
Ep.cells of the int.of cat
Different organs
Stomach
Blood
Sporozoite
Pathogenesis
Congenitally :
A- Intra cerebral calci fication :‫تكلس داخل المخ‬
B- Chorioretinitis :‫التهاب المشيمية والشبكية‬
C- Hydro cephalus :‫تجمع الماء في الرأس‬
D- Encephalitis :‫التهاب الدماغ‬
Acquired
A- Lymphodenitis : ) ‫( حمى – فقر دم – انخفاض ضغط االم عضلية‬
‫التهاب لمفاوي‬
B- Acute infection Example :- * Encephalomyelitis ‫التهاب السحايا‬
* Pneumonitis ‫التهاب الرئة‬
* Nyo carditis ‫التهاب العضلة القلبية‬
C- Chronic Toxoplasmosis )‫ضعف عضلي‬-‫فقدان الوزن‬-‫(صداع‬
Diagnosis
Diagnosis is based on serology
by :- * Inhibition Fluorecent anti body test .
*ELISA test
*Indirect haemaglutination test
And on histologic examination of tissue .
Treatment :1-Pyrimethamine 25mg every day (3-4) weaks .
2- Sulfonamides .
3- Sulfadiazine .
4- Sulfamethazine and sulfamerazine
Figure-4- Girl with hydrocephalus due to congenital toxoplasmosis.
Figure-5- Girl with hydrocephalus due to congenital toxoplasmosis.