National Institute
for Public Health
and the Environment
ACROPOLIS
Jacob van Klaveren
Contents
• History and starting point
• Aims of ACROPOLIS
• Main overview (WPs)
• Project organisation
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for Public Health
and the Environment
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Starting point for ACROPOLIS
• An electronic platform for pan-European
exposure modelling as created in SAFE FOODs
• Existing models like EuroPOEM, CONSEXPO,
MCRA, IPRA
• EFSA opinions on cumulative risk assessment
National Institute
for Public Health
and the Environment
Jacob van Klaveren ACROPOLIS kick-off meeting
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Aims of ACROPOLIS
National Institute
for Public Health
and the Environment
•
Improve cumulative exposure and hazard assessment
•
Create new models for aggregated exposure assessment
•
Setting up new toxicological testing for identifying synergistic
effects
•
To integrate cumulative and aggregated risk models
•
Improve understanding of methodology of different stakeholders
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E-platform of databases (food and residue)
SE
NL
CZ
UK
IT
FR
0.4
0.2
0.0
-3.6
-2.9
-2.2
-1.4
-0.7
0.0
0.7
1.4
2.2
2.9
3.6
MCRA-software
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for Public Health
and the Environment
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Toxicological BMD modeling
van der Voet & Slob (2007)
• Critical effect dose
• Number of experiments
• EFSA opinion BMD modeling
National Institute
for Public Health
and the Environment
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Aggregated exposure assessment
Combine leading models in Europe
(MCRA, EUROPOEM, ConsEXPO)
Case studies with two or more different routes of
exposure
Validation of the model
National Institute
for Public Health
and the Environment
Jacob van Klaveren ACROPOLIS kick-off meeting
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Mixtures and internal does
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for Public Health
and the Environment
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Model and software development
Internet compatible model and data
National Institute
for Public Health
and the Environment
•
Test and justify underlying assumptions
•
Scientific sound
•
Reproducible and transparent (reference manual MCRA openly
available)
•
Include quantitative uncertainty analyses
•
Data in connection with model available for stakeholders
(including industry). Not the raw data.
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Risk based on Margin of Exposure
Be aware that safety factors are also modelled!
National Institute
for Public Health
and the Environment
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Dissemination
•
Training
•
Stakeholder conferences
•
Website and folders
•
Scientific paper on stakeholders attitudes towards
cumulative and aggregated exposure levels
National Institute
for Public Health
and the Environment
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Stakeholders
• Industry
• Regulators
• EFSA and risk assessors at national level
• Risk Management
National Institute
for Public Health
and the Environment
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ACROPOLIS PROJECT STRUCTURE
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for Public Health
and the Environment
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External advisory board
EFSA (Luc Mohimont)
DG Sanco (Bas Drukker)
EPA (D. Miller will be asked)
Coordinator
- Further elaboration on case studies
- Overview needs of DG Sanco (risk managers)
- Fine-tune research needs of EFSA
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for Public Health
and the Environment
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Scientific Advisory Board
WHO, FAO, experts (dr. C. Harris, prof A. Boobis, prof
W. Steurbout, dr. D Hamilton), Greenpeace (dr. M.
Krauter), Industry (Bayer, BASF, Syngenta)
- To convey relevant issues from a stakeholders perspective
- To bring in relevant expertise (e.g. from USA)
- Emerging issues in pesticide risk assessment
- Implementation of project outcomes at EU level
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for Public Health
and the Environment
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Deliverables and milestones
A deliverable is a result that has to be produced
(e.g. a paper, a model, or any other result)
A milestone is something that you have to achieve
before you can continue
All have to be done in time and as promised
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for Public Health
and the Environment
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Project Management Team
• A representative of each beneficiary
• Stop-go decisions
• Contingency plan (coordinator)
• Financial issues as far as they deviate from proposal
• Gender issues
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for Public Health
and the Environment
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National Institute
for Public Health
and the Environment
Thanks for your attention!
jacob.van.klaveren@rivm.nl
MCRA model
EFSA opinion
RIKILT report
: https://mcra.rikilt.wur.nl/
: EFSA website