BSRBR-RA
UK CRN ID: 7302
March 2014 update
Recruitment
Numbers recruited
up to 22/01/2014
Certolizumab
Must have
diagnosis of
RA
Must be registered
within 6 months of first
dose of certolizumab
Can be re-registered
if already on the
study
735
As of 22/01/2014
Tocilizumab
Must have
diagnosis of
RA
Must be registered
within 6 months of first
dose of tocilizumab
Can be re-registered
if already on the
study
633
As of 22/01/2014
Anti-TNF Comparison Cohort
Must have
diagnosis of
RA
Must be registered within 6 months of first dose
of etanercept, adalimumab or infliximab
561
As of 22/01/2014
Recruitment
Certolizumab recruitment by month
July 2011
January 2014
Tocilizumab recruitment by month
January 2014
July 2011
60
Anti-TNF cohort recruitment by
month
30
0
Dec2011
January 2014
Recruitment
01/07/2013 – 22/01/2014
BSR Region Awards
July 2013 – January 2014
North
West
85
East
Midlands
80
West
Midlands
60
Help is available with the BSRBR-RA
If you do not have enough staff support currently, then in England the National Institute for Health Research Comprehensive
Clinical Research Network (CCRN) may be able to provide assistance
What is the CCRN?
The CCRN is made up of 25 Comprehensive Local Research Networks (CLRNs) which cover the whole of England. Each local
Network facilitates research within their region, with the aim of widening participation in research. A study is eligible for
CLRN assistance if it has been adopted on to the Network portfolio of studies; the BSRBR-RA was adopted on to this
portfolio in 2008 (ID: 7302).
How can my CLRN help me?
The CLRN may be able to help by assisting in R&D set up or by providing funding for the people/facilities you require in
order to carry out research in which you are involved in. For example, you may be allocated research nurse time or a data
clerk to assist with the recruitment and follow up of participants on the BSRBR-RA.
How can I apply for CLRN help?
You should contact the team within your regional network (details found via the link below) to discuss your requirements.
You will then have to complete an application form, with which we can help.
www.crncc.nihr.ac.uk/about_us/ccrn/ccrn_about_us/clrns_list.htm
The BSRBR-RA Study reference number within the Network is 7302 – please remember to quote this when asking for help
with the study. If you need any help with completing the paperwork, please contact katy.mowbray@manchester.ac.uk
Is there help outside of England?
Regional Support
Northern Ireland
Wales
The Northern Ireland Clinical
Research Network (NICRN) may
be able to provide assistance in
Northern Ireland in the same
way as the NIHR CCRN in
England, please contact the team
to discuss requirements:
The National Institute for Social
Care and Health Research
Clinical Research Centre (NISCHR
CRC) may be able to provide
assistance in Wales in the same
way as the NIHR CCRN in England
, please contact the team to
discuss requirements:
info.NICRN@belfasttrust.hscni.net
nischr-crc@wales.nhs.uk
Scotland
NHS Scotland may be able to
provide assistance in Scotland in
the same way as the NIHR CCRN
in England, please contact the
team to discuss if support is
possible for you:
http://nrs.mtcserver8.com/297
_ClinicalResearchNetworks.html
Recent BSRBR-RA publications
– Biologic treatment response among adults with juvenile idiopathic
arthritis: results from the British Society for Rheumatology Biologics
Register.
McErlane, F., Foster, H., Davies, R., Lunt, M., Watson, K., Symmons, D.
& Hyrich, K (2013). Rheumatology (Oxford), [Epub ahead of print],
DOI:10.1093/rheumatology/ket248
– Anti-TNF therapy in women with rheumatoid arthritis with a history of
carcinoma in situ of the cervix.
Mercer, L., Low, A., Galloway, J., Watson, K., Lunt, M., Symmons, D., Hyrich, K.
& BSRBR_Control_Centre_Consortium, B (2013). Ann Rheum Dis, 72(1), 143144.
– The risk of gastrointestinal perforations in patients with rheumatoid
arthritis treated with anti-TNF therapy: results from the BSRBR-RA.
Závada, J., Lunt, M., Davies, R., Low, A., Mercer, L., Galloway, J., Watson, K.,
Symmons, D., Hyrich, K. & , B (2013). Ann Rheum Dis, [Epub ahead of print]
Accessing BSRBR-RA data
http://www.rheumatology.org.uk/resources/bsr_biologics_registers/requesting_bsrbr_data_and_external_projects
Recent/ongoing research projects via
the BSRBR-RA data access scheme
 Non-inflammatory pain mechanisms as confounders in the clinical assessment of
synovitis in RA
 Study of fatigue in inflammatory arthritis
 Effectiveness of TNF response define by season of initiation of therapy, with
particular focus on vitamin D
 To explore the influence of gender and gender-related variables on severity of
prognosis for RA
 Obesity and clinical response to anti-TNF medication
Dr Audrey Low – Jewel in the Crown oral presentation
Title: Incidence and severity of myocardial infarction in subjects receiving anti tumour necrosis
factor drugs for rheumatoid arthritis: results from linking the British Society for Rheumatology
biologics register for rheumatoid arthritis and the myocardial ischaemia national audit project.
Session: Jewels in the crown Session Date and time: Tuesday Apr 29, 2014 2:15 PM - 4:15 PM
Talk time: 3:35PM - 3:55PM
Dr Audrey Low – poster presentation
Title: Non-differential reporting of myocardial infarction to a national observational drug safety
study using linked data: linkage of the British Society for Rheumatology biologics register for
rheumatoid arthritis and the myocardial ischaemia national audit project.
Poster number: 039 Session Date and time: Tuesday Apr 29, 2014 10:30AM - 11:30 AM
Dr Lucia Silva-Fernandez – oral presentation
Title: The influence of anti-TNF or Rituximab on cancer incidence in patients with rheumatoid
arthritis who have had a prior malignancy.
Session: Rheumatoid arthritis oral abstracts Session Date and time: Wednesday Apr 30, 2014
09:00AM - 10:30 AM Talk time: 10:00AM - 10:15PM
What to look out for in the future
1) Web portal development
The Robertson Centre at the University of Glasgow are going to
develop a new web portal for online data capture.
The portal will include the facility to register new patients as
well as enter follow-up data for patients already on the study
Acknowledgements
• UK Consultant Rheumatologists and Specialist Nurses
• Comprehensive Local Research Networks
• BSRBR-RA Control Centre Consortium
• British Society for Rheumatology
• Arthritis Research UK Centre for Epidemiology,
Manchester