Lecture 5 Guided Notes:
Mutations and Gene Expression Regulation
Part 1: Definitions

Deletion:

Insertion:

Frameshift Mutation:

Gene Regulation:

Germ Cell:

Missense Mutation:

Mutagen:

Mutation:

Nonsense Mutation:

Nucleotide Substitution:

Silent Mutation:

Somatic Cell:
Part 2: Discussion Questions
1. Compare and contrast nucleotide mutations and frameshift mutations.
2. Describe the possible ways that mutations can be introduced into a sequence of
DNA.
3. What makes a mutation MORE or LESS detrimental?
4. Give an example of how mutations can be beneficial as well as an example of how
mutations can be harmful.
5. Explain why regulating gene expression is of importance to an organism.
6. Explain simply how gene therapy using CRISPR/Cas9 works. What is the purpose
and end-product of this therapeutic approach?