ALI SABAH RASOOL
For Pka is the base, but here we are talking about N in H because 10.4 = unsubstituted
sulfanilamide (N for Pka).
Thiadiazol (without substitute) Reduces PKa from 10.4 to 7.4.
(Iodine addition at position 3) Reduces PKa by only 0.1-0.2.
Net effect:
PKa 7.4 - 0.15 ≈ 7.25
This in the range and make the compound more antibacterial activity and less form crystalluria
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