The Hallmarks of Aging (The Hallmarks of Aging - Oxford Healthspan)
1. Genomic instability -BAD
2. Telomere shortening -BAD
3. Epigenetic alterations -BAD
4. Loss of proteostasis -BAD
5. Deregulated nutrient sensing – Sometimes bad
6. Mitochondrial dysfunction – Sometimes bad
7. Cellular senescence – Sometimes bad
8. Stem cell exhaustion – This is the end
9. Altered intercellular communication - This is the end
Hallmark of Aging #1: Genomic Instability
Hallmark of Aging #1: Genomic Instability - Oxford Healthspan
Hallmark of Aging #2: Telomere Attrition
Hallmark of Aging #2: Telomere Attrition - Oxford Healthspan
Hallmark of Aging #3: Epigenetic Alterations
Hallmark of Aging #3: Epigenetic Alterations - Oxford Healthspan
1. DNA methylation
2. Histone modifications