Rad Tech’s Guide to Radiation protection is a core element of radiologic technology programmes and daily practice alike. Rad Tech’s Guide to Radiation Protection is a comprehensive yet compact guide designed to illuminate the extensive field of radiation protection for technologists, trainees, and radiology students. Organised into ten digestible chapters, the second edition of this popular book provides new discussions of dose factors in computed tomography, the debate concerning the use of the LNT model, Diagnostic Reference Levels (DRLs), dose optimization, and more. Written by a recognised expert in medical radiation sciences, this valuable guide: • Reflects the most current standards for radiation protection, with references to relevant organisations and resources • Covers basic radiobiology, sources of radiation exposure, dose management regulations and optimization, and more • Presents essential information in a bulleted, easy-to-reference format Rad Tech’s Guide to Radiation Protection is a must-have resource for student radiographers and radiology technologists, particularly those preparing for the American Registry of Radiation Technologist (ARRT) exams. www.wiley.com Seeram Cover Design: Wiley Cover Image: © Hero Images/Getty Images Second Edition Euclid Seeram, PhD, FCAMRT, is a Full Member of the Health Physics Society and has academic appointments as Honorary Senior Lecturer in Medical Radiation Sciences at the University of Sydney, Australia; Adjunct Associate Professor of Medical Imaging and Radiation Sciences at Monash University, Australia; Adjunct Professor in the Faculty of Science at Charles Sturt University, Australia; and Adjunct Professor of Medical Radiation Sciences at the University of Canberra, Australia. RADIATION PROTECTION • Helps students and technologists acquire the skills required to protect patients, personnel, and members of the public in the radiology department Rad Tech’s Guide to RADIATION PROTECTION Second Edition Euclid Seeram SERIES EDITOR Rad Tech’s Guide to Radiation Protection 0004398304.INDD 1 7/5/2019 4:44:08 PM 0004398304.INDD 2 7/5/2019 4:44:08 PM Rad Tech’s Guide to Radiation Protection Second Edition Euclid Seeram, PhD, FCAMRT Full Member – Health Physics Society Academic Appointments Honorary Senior Lecturer; Medical Radiation Sciences; Faculty of Health Sciences; University of Sydney, Australia | Adjunct Associate Professor; Medical Imaging and Radiation Sciences; Monash University, Australia | Adjunct Professor; Faculty of Science; Charles Sturt University, Australia | Adjunct Professor; Medical Radiation Sciences; Faculty of Health; University of Canberra, Australia 0004398304.INDD 3 7/5/2019 4:44:08 PM This edition first published 2020 © 2020 John Wiley & Sons Ltd Edition History Blackwell Science. 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Library of Congress Cataloging‐in‐Publication Data Paperback ISBN: 9781119640837 Cover Design: Wiley Cover Image: © Hero Images/Getty Images Set in 11.5/13.5pt STIX Two Text by SPi Global, Pondicherry, India 10 0004398304.INDD 4 9 8 7 6 5 4 3 2 1 7/5/2019 4:44:08 PM This book is dedicated with love and affection to my lovely and charming wife Trish, a brilliant, hard‐working, caring, and loving individual, who taught me the very essence of life. 0004398304.INDD 5 7/5/2019 4:44:08 PM 0004398304.INDD 6 7/5/2019 4:44:08 PM Contents Preface to the Second Edition.. . . . . . . . . . . . . . . . . . .xi Acknowledgments. . . . . . . . . . . . . . . . . . . . . . . . . . . .xiii 1 Nature and Scope of Radiation Protection. . . . . . . . . 1 What is Radiation Protection?. . . . . . . . . . . . . . . . . . . . . . . . . .2 Scope of Radiation Protection . . . . . . . . . . . . . . . . . . . . . . . . .2 Diagnostic Radiology Modalities. . . . . . . . . . . . . . . . . . . . . . .3 Why Protect Patients and Personnel in Diagnostic Radiology? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3 Framework for Radiation Protection. . . . . . . . . . . . . . . . . . . .4 Basic Schemes for Patient Exposure in Digital Radiography, Fluoroscopy, and Computed Tomography. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6 Factors Affecting Dose in Diagnostic Radiology. . . . . . . . . .8 Dose Management Techniques . . . . . . . . . . . . . . . . . . . . . . .10 Pregnancy: Radiation Protection Considerations. . . . . . . .11 2 Diagnostic X-Rays: Essential Physical Factors . . . . . 13 X-Ray Production. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Mechanisms for Creating X-Rays. . . . . . . . . . . . . . . . . . . . . .14 X-Ray Spectrum. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16 X-Ray Attenuation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .20 X-Ray Interactions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Increasing kV and Scatter Production.. . . . . . . . . . . . . . . . .26 3 Radiation Quantities and Units . . . . . . . . . . . . . . . . . 27 Sources of Radiation Exposure. . . . . . . . . . . . . . . . . . . . . . . 29 Types of Exposure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 0004398305.INDD 7 7/8/2019 12:32:42 PM viii Contents Quantities and Units for Quantifying Ionizing Radiation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .31 Quantities and Units for Quantifying Biologic Risks . . . . 33 Radiation Measurement . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 Wearing a Personnel Dosimeter . . . . . . . . . . . . . . . . . . . . . 38 4 Basic Radiobiology. . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 What Is Radiobiology?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .41 Essential Physics and Chemistry . . . . . . . . . . . . . . . . . . . . . .41 Fundamental Concepts of Radiobiology. . . . . . . . . . . . . . . 44 Deterministic Effects (Early Effects of Radiation). . . . . . . .49 Stochastic Effects (Late Effects of Radiation). . . . . . . . . . . .51 Radiation Exposure During Pregnancy. . . . . . . . . . . . . . . . 54 5 Current Standards for Radiation Protection.. . . . . . 55 Radiation Protection Organizations . . . . . . . . . . . . . . . . . . 56 Objectives of Radiation Protection . . . . . . . . . . . . . . . . . . . .57 Radiation Protection Criteria and Standards. . . . . . . . . . . 58 Recommended Dose Limits . . . . . . . . . . . . . . . . . . . . . . . . . 60 Diagnostic Reference Levels: A Useful Tool for Optimization of Protection. . . . . . . . . . . . . . . . . . . . . . . 62 6 Dose Factors in Digital Radiography. . . . . . . . . . . . . 65 Digital Radiography: Essential Considerations. . . . . . . . . 66 The Standardized Exposure Indicator: Basics. . . . . . . . . . 68 Factors Affecting Dose in Digital Radiography. . . . . . . . . .70 7 Dose Factors in Fluoroscopy. . . . . . . . . . . . . . . . . . . . 77 Major Components of Fluoroscopic Imaging Systems.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .78 Factors Affecting Dose in Fluoroscopy. . . . . . . . . . . . . . . . 82 Scattered Radiation in Fluoroscopy. . . . . . . . . . . . . . . . . . . 87 0004398305.INDD 8 7/8/2019 12:32:42 PM Contents ix 8 Factors Affecting Dose in Computed Tomography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 Computed Tomography: A Definition. . . . . . . . . . . . . . . . . 90 Nobel Prize for CT Pioneers . . . . . . . . . . . . . . . . . . . . . . . . . .91 CT Principles: the Basics . . . . . . . . . . . . . . . . . . . . . . . . . . . . .91 Multislice CT Technology: The Pitch . . . . . . . . . . . . . . . . . . .93 Dose Distribution in CT. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .93 CT Dose Metrics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94 Factors Affecting the Dose in CT. . . . . . . . . . . . . . . . . . . . . 96 Dose Optimization in CT . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 9 Dose Management Regulations and Optimization. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .101 Federal Regulations for Dose Management . . . . . . . . . . 103 Equipment Specifications for Radiography. . . . . . . . . . . 104 Equipment Specifications for Fluoroscopy. . . . . . . . . . . . 106 Procedures for Minimizing Dose to Patients and Personnel. . . . . . . . . . . . . . . . . . . . . . . . . . 109 Shielding: Design of Protective Barriers. . . . . . . . . . . . . . .112 Quality Assurance: Dose Management and Optimization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .114 10 Pregnancy: Essential Radiation Protection Considerations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117 Rationale for Radiation Protection in Pregnancy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .118 Factors Affecting Dose to the Conceptus. . . . . . . . . . . . . .119 Estimating the Dose to the Conceptus. . . . . . . . . . . . . . . .120 Continuing/Terminating a Pregnancy After Exposure.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .120 0004398305.INDD 9 7/8/2019 12:32:42 PM x Contents Dose Reduction Techniques for Pregnant Patients. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .121 The Pregnant Worker. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .121 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .129 0004398305.INDD 10 7/8/2019 12:32:42 PM Preface to the Second Edition R adiation protection in medicine has experience an evolution through the years and has focused mainly on developing new procedures for optimizing the dose to the patient, based on objective evidence and knowledge of the biological effects of radiation exposure to not only humans but animals as well. These data have suggested that the doses from medical radiation are high and that every effort must be made to manage the dose to both patients and personnel. Another concept developed from these data is that of a dose‐risk model or simply a dose‐response relationship. Several models have been proposed but the one that has been supported for use in medical radiation exposure to patients is the Linear No Threshold (LNT) model. Experts Hendee and O’Connor (2012) provide a guiding argument for the use of the LNT model in diagnostic radiology as follows: This model is not chosen because there is solid biologic or epidemiologic data supporting its use. Rather, it is used because of its simplicity and because it is a conservative approach … For the purpose of establishing radiation protection standards for occupationally exposed individuals and members of the public, a conservative model that overestimates the risk is preferred over a model that underestimates risk Radiation protection is an essential core subject of radiologic technology programs. To meet the needs of these programs, a handful of books on radiation protection is currently available to enable students and technologists alike to acquire the skills required to protect patients, personnel, and members of 0004398306.INDD 11 7/8/2019 12:33:51 PM xii Preface to the Second Edition the public in the radiology department. This book, Rad Tech’s Guide to Radiation Protection, provides a comprehensive practical guide for technologists and students engaged in the art and science of radiation protection. It main goal is to provide a resource that is brief, clear, and a concise coverage of the subject in preparation for their professional certification examination. Rad Tech’s Guide to Radiation Protection is not a textbook and it is not intended to replace the vast resources on radiation protection. Rather, it provides a précis of the extensive coverage of radiation protection topics for technologists. Rad Tech’s Guide to Radiation Protection contains 10 short chapters that cover a wide scope of topics on radiation protection. For this second edition, a new chapter on Dose Factors in Computed Tomography has been added, and a few new concepts have been introduced into the appropriate chapters. For example, the debate concerning the use of the LNT model has been included in Chapter 4, While Diagnostic Reference Levels (DRLs) are briefly outlined in Chapter 5, and Dose Optimization is reviewed briefly in Chapter 9. Chapter 1 discusses the nature and scope of radiation protection and sets the framework for the remaining chapters. While Chapter 2 presents a description of the essential physics for radiation protection, Chapter 3 describes radiation quantities and their units. Chapter 4 outlines the basic concepts of radiobiology and Chapter 5 provides a rationale for radiation protection. Chapters 6 and 7 address the factors that affect dose levels in digital radiography and fluoroscopy, respectively. Additionally, Chapter 8 is a new Chapter on Factors Affecting the Dose in Computed Tomography. Chapter 9 provides a discussion of Dose Management Regulations and Optimization. Finally, Chapter 10 reviews radiation protection considerations in pregnancy. Enjoy the pages that follow and remember – your patients will benefit from your wisdom. Euclid Seeram, PhD, FCAMRT British Columbia, Canada 0004398306.INDD 12 7/8/2019 12:33:51 PM Acknowledgments I t is a pleasure to acknowledge the contributions of experts in the fields of radiobiology and radiation protection, from whom I have learned a great deal that allows me to write this book. First, I must acknowledge James Watson, Commissioning Editor, Wiley, Oxford, UK, who understood and evaluated the need for a second edition of this book. Additionally, I am grateful to Anupama Sreekanth, the project editor for this title at Wiley, for all the advice and support provided to me during the writing of this book. Second, I am indeed grateful to all those who have dedicated their energies in providing several comprehensive volumes on medical radiation protection for the radiologic community. I would like to acknowledge the notable medical physicist, Dr. Stewart Bushong, ScD, FAAPM, FACR, and experimental radiobiologist, Dr. Elizabeth Travis, PhD. I have learned a great deal on radiologic science from the works of Dr. Bushong, a professor of radiologic science in the Department of Radiology, Baylor College of Medicine, Houston, Texas. In addition, I have gained further insight into the nature, scope, and depth of radiobiology, and particularly its significance in radiology, from Dr. Travis, a researcher in the Department of Experimental Radiotherapy, University of Texas, MD, Anderson Cancer Center, Houston, Texas. Furthermore, I would like to thank Dr. Hans Swan, PhD, and Dr. Rob Davidson, PhD, who served as my primary supervisors for my PhD dissertation entitled Optimization of the Exposure Indicator of a Computed Radiography Imaging System as a Radiation Dose Management Strategy. I must acknowledge, too, all others, such as the authors whose papers I have cited and referenced in this book – thank you for your significant contributions to the radiation protection knowledge base. Additionally, I would like to express my sincere thanks to Dr. Perry Sprawls, PhD, FACR, FAAPM, FIOMP, 0004398307.INDD 13 7/8/2019 12:35:46 PM xiv Acknowledgments Distinguished Emeritus Professor, Emory University, Director, Sprawls Educational Foundation, http://www.sprawls.org, Co‐ Director, College on Medical Physics, ICTP, Trieste, Italy, and Co‐Editor, Medical Physics International, http://www.mpijournal. org. Dr. Sprawls has always supported my writing and I appreciate his gracious permission to use his materials (illustrations in particular) in my textbooks on radiation protection. Thank you, Perry. Finally, I must acknowledge the warm and wonderful support of my family; my lovely wife, Trish, a very wise and caring person, and my very smart son, David, a very special young man, and the best Dad in the universe. Thank you both for your unending love, support, and encouragement. Last, but not least, I want to express my gratitude to all the students in my radiation protection classes – your questions have provided me with a further insight into teaching this important subject. 0004398307.INDD 14 7/8/2019 12:35:46 PM 1 Nature and Scope of Radiation Protection Chapter at a Glance What is Radiation Protection? Scope of Radiation Protection Diagnostic Radiology Modalities Why Protect Patients and Personnel in Diagnostic Radiology? Framework for Radiation Protection Radiation Protection Principles Radiation Protection Actions Basic Schemes for Patient Exposure in Digital Radiography, Fluoroscopy, and Computed Tomography Digital Radiography Fluoroscopy Computed Tomography Factors Affecting Dose in Diagnostic Radiology Radiographic Factors Fluoroscopic Factors Computed Tomography Factors Rad Tech’s Guide to Radiation Protection, Second Edition. Euclid Seeram. © 2020 John Wiley & Sons Ltd. Published 2020 by John Wiley & Sons Ltd. 0004398308.INDD 1 7/8/2019 12:37:11 PM 2 Rad Tech’s Guide to Radiation Protection Dose Management Techniques Pregnancy: Radiation Protection Considerations R adiation protection is one of the most important subjects in the education and practice of medical imaging technologies using ionizing radiation, because it deals with the safe use of ionizing radiation when imaging patients for the purpose of restoring their health. The purpose of this chapter is to orient both students and practicing technologists to the nature and scope of radiation protection specifically in diagnostic x‐ray imaging (radiography/ radiology) and to provide a brief overview of topics essential to the theory and practice of radiography. What is Radiation Protection? Radiation protection is concerned with the protection of persons from the harmful effects of exposure to radiation. In radiography/radiology radiation protection deals with the protection of patients and operators, as well as members of the public. Why? ◼◼ Patients are exposed to varying amounts of radiation from the x‐ray tube, depending on the type of examination. ◼◼ Personnel may be exposed to radiation scattered from the patient and the equipment. ◼◼ Members of the public, in this instance, are individuals who are working or waiting in close proximity to an x‐ray room. These include, for example, radiology support staff and family members of patients. Scope of Radiation Protection The scope of radiation protection includes knowledge and ­understanding of the following: ◼◼ Physical factors. These are related to the physics of ­r adiation, including energy dissipation in matter, 0004398308.INDD 2 7/8/2019 12:37:11 PM Nature and Scope of Radiation Protection 3 c­ haracteristics of radiation, interaction of radiation with matter, and the physical and chemical factors of radiation. ◼◼ Technical factors. These include a range of topics such as technical components of imaging systems that affect dose, standards of radiation protection, dose management techniques, and shielding considerations. ◼◼ Procedural factors. These relate to personnel practices during the examination and include such tasks as equipment set‐up, patient communication and positioning, selection of technical factors, gonadal shielding, image processing, and image assessment. ◼◼ Biologic factors. The biologic effects of radiation result from the physical and chemical interaction of radiation with matter (tissue). Bioeffects can be somatic (effects that appear in the individual exposed to radiation) or they can be genetic (effects that appear in the offspring of the individual exposed). Bioeffects are now classified as stochastic and deterministic (nonstochastic) effects. These are described further in Chapter 3. Diagnostic Radiology Modalities The diagnostic radiology modalities that are described in this book are digital radiography, fluoroscopy, and computed tomography (CT). The basic approaches to exposing a patient to the radiation beam during imaging, depend on the beam geometry. These approaches are described in brief later in the chapter. Why Protect Patients and Personnel in Diagnostic Radiology? There are several major reasons for protecting patients undergoing radiographic examination as well as for protecting the personnel conducting the examination. These reasons include: ◼◼ Biologic effects data demonstrate beyond question that radiation exposure is harmful to humans. 0004398308.INDD 3 7/8/2019 12:37:11 PM 4 Rad Tech’s Guide to Radiation Protection ◼◼ Patients receive more radiation exposure from diagnostic radiology compared with any other man‐made radiation sources. ◼◼ No dose of radiation is considered safe (there is no risk‐ free dose of radiation). ◼◼ Various research studies reveal that some diagnostic x‐ray examinations, particularly involving fluoroscopy and CT, deliver high doses of radiation to patients. ◼◼ Technologists assume full responsibility for all aspects of the radiographic examination, including radiation exposure of the patient. Protection of patients and operators (technologists and radiologists) depends on the technical expertise of both the technologist and the radiologist. ◼◼ Radiation safety is guided by several principles and actions set forth by the International Commission on Radiological Protection (ICRP); these are meant to keep all exposures as low as reasonably achievable (ALARA). Framework for Radiation Protection A framework refers to a supporting structure or a basic system. A radiation protection framework includes a number of concepts intended to prevent and minimize the harmful effects of radiation exposure. The ICRP offers one comprehensive framework that is accepted by various national radiation protection organizations, including the National Council of Radiation Protection and Measurements (NCRP) in the United States, the Radiation Protection Bureau (part of Health Canada), the National Radiological Protection Board (NRPB) in the United Kingdom, as well other radiation protection organizations around the world. The ICRP framework encompasses several notable concepts, including the types of exposure from which individuals can receive a dose of radiation and a concept of significance to technologists and radiologists called the two triads of radiation protection. 0004398308.INDD 4 7/8/2019 12:37:11 PM Nature and Scope of Radiation Protection 5 The types of exposure include: ◼◼ Occupational exposure. Exposure from work activities. ◼◼ Medical exposure. Exposure from diagnostic and therapy procedures, which does not include occupational exposure. ◼◼ Public exposure. All other exposures from natural sources of radiation, such as radon gas. There are several other concepts that constitute the ICRP framework. However, the two triads of radiation protection are discussed here. These two triads define current radiation protection standards and include: ◼◼ Radiation protection principles. ◼◼ Radiation protection actions. Radiation Protection Principles Radiation protection principles include the following three fundamental guiding concepts: ◼◼ Justification. This concept focuses on net benefit. That is, there must be a benefit associated with any new modality, procedure, or exposure. ◼◼ Optimization. This concept dictates that all exposures be kept as low as reasonably achievable (ALARA), taking into consideration social and economic factors. ◼◼ Dose limitation. By establishing dose limits to persons exposed to radiation, certain harmful effects can be prevented and others can be minimized. These limits are numerical values representing an upper limit of exposure annually. For example, the ICRP recommends an annual dose limit to the lens of the eye of 150 millisieverts (mSv) or 15 000 millirem (mrem) for occupationally exposed individuals. Dose limits are discussed in Chapter 5. 0004398308.INDD 5 7/8/2019 12:37:11 PM 6 Rad Tech’s Guide to Radiation Protection Radiation Protection Actions Radiation protections actions are based on the following three concepts: ◼◼ Time. Because dose is directionally proportional to the length of time of exposure, it is important to decrease the time of the exposure to decrease the dose. If the time is decreased by a factor of two, then the dose will be reduced by a factor of two. ◼◼ Shielding. To reduce the dose to patients and others, it is essential to place a shield between the source of radiation (x‐ray tube) and the individual exposed (patient). Gonadal shielding is a prime example of this concept. ◼◼ Distance. The dose an individual receives is inversely proportional to the square of the distance. This factor is known as the inverse square law and it is expressed as I 1/d 2 where I is equal to the intensity of the radiation and d equals the distance from the source of the radiation to the individual exposed. As the distance is increased, the dose is reduced proportionally to the square of the distance. Basic Schemes for Patient Exposure in Digital Radiography, Fluoroscopy, and Computed Tomography The basic scheme for patient exposure refers to the beam geometry used to expose the anatomical area of interest, as illustrated in Figure 1.1, for radiography, fluoroscopy, and CT. The beam geometry refers to the size and shape of the x‐ray beam emanating from the x‐ray tube. Beam geometry also refers to whether the beam is fixed or is moving during the exposure. Whereas in radiography, the beam is fixed during the exposure 0004398308.INDD 6 7/8/2019 12:37:11 PM Nature and Scope of Radiation Protection X-ray tube X-ray tube Open beam geometry 7 X-ray tube Beam geometry Patient Patient Patient Digital detector Digital detector Two-dimensional detector (a) Radiography (b) Fluoroscopy (c) Computed Tomography Figure 1.1 The basic scheme for patient exposure refers to the beam geometry used to expose the anatomical area of interest, as illustrated for (a) digital radiography, (b) fluoroscopy, and (c) computed tomography (CT). (with the exception of digital radiographic tomosynthesis), it is moved about the patient during a fluoroscopic examination. In CT, the beam rotates around the patient during the exposure. The details of each of are described in later chapters. Digital Radiography In radiography, specifically digital radiography: ◼◼ The beam geometry describes an open beam (Figure 1.1a) shaped by the collimator to fall on the area of interest on the patient. ◼◼ The beam is fixed on this area of interest during the exposure. ◼◼ The beam is collimated to the size of the digital image receptor used for the examination. ◼◼ Radiographic exposure technique factors, such as mA, kV, and exposure time in seconds, are used to produce the x‐rays needed to create images of the patient. ◼◼ Images are static and each image requires a separate x‐ ray exposure. 0004398308.INDD 7 7/8/2019 12:37:11 PM 8 Rad Tech’s Guide to Radiation Protection Fluoroscopy In fluoroscopy (conventional or digital): ◼◼ The beam geometry describes an open beam (Figure 1.1b) shaped by the collimator to fall on the regions of interest being imaged. ◼◼ The beam is moving during fluoroscopic exposures. This movement is necessary to track the flow of contrast media through the anatomy, such as the gastrointestinal tract. ◼◼ The beam is collimated to the size of the image receptor. ◼◼ Fluoroscopic exposure technique factors, generally low mA (approximately 1–3 mA) and high kV, are used to show fluoroscopic images displayed on a television ­monitor. The x‐ray tube is energized for longer periods compared with the short exposure times used in radiography. ◼◼ Radiographic exposure technique factors are used by the technologist who records “overhead” images after the fluoroscopic portion of the examination. This is the radiographic component of a routine fluoroscopic examination. Computed Tomography In CT, the x‐ray beam is a cone (Figure 1.1c) that rotates 360° around the patient while the patient moves through the CT scanner gantry opening during the collection of transmission x‐ray readings, to build up a sectional image of the anatomy being imaged. Factors Affecting Dose in Diagnostic Radiology To protect patients, personnel, and members of the public from radiation in diagnostic radiology, it is mandatory that technologists have a firm understanding of the various factors affecting dose. In this text, only essential dose factors in radiography, fluoroscopy, and CT are considered. 0004398308.INDD 8 7/8/2019 12:37:11 PM Nature and Scope of Radiation Protection 9 Radiographic Factors The technical factors affecting patient dose in radiography are: ◼◼ Type of x‐ray generator. ◼◼ X‐ray exposure technique factors (mA, kV, and time). ◼◼ Beam energy and filtration. ◼◼ Collimation and field size. ◼◼ Distance from the x‐ray tube to the patient (source‐ to‐skin distance) and the distance from the x‐ray tube to the image receptor (source‐to‐image receptor ­distance, SID). ◼◼ Patient thickness and density. ◼◼ Antiscatter grids. ◼◼ Image receptor sensitivity. ◼◼ Shielding. ◼◼ Repeat examinations. ◼◼ Patient orientation. Fluoroscopic Factors The technical factors affecting dose in fluoroscopy are numerous and include: ◼◼ Beam energy and tube current. ◼◼ Collimation. ◼◼ Source‐to‐skin distance. ◼◼ Patient‐to‐image intensifier distance. ◼◼ Beam‐on time. ◼◼ Antiscatter grids. ◼◼ Image magnification. ◼◼ Conduct of the fluoroscopic portion of the examination. ◼◼ Conduct of the radiographic portion of the fluoroscopic examination. The factors for radiography and fluoroscopy are elaborated further in Chapters 6 and 7 respectively. 0004398308.INDD 9 7/8/2019 12:37:11 PM 10 Rad Tech’s Guide to Radiation Protection Computed Tomography Factors There are several technical factors affecting dose in CT. However, only the ones that are under the control of the technologist are listed here. These include: ◼◼ Exposure technique factors (mAs and kV). ◼◼ Collimation and slices. ◼◼ Pitch. ◼◼ Noise index. ◼◼ Automatic exposure control. ◼◼ Overranging and overbeaming. ◼◼ Iterative reconstruction algorithms. These factors are described further in Chapter 8. Dose Management Techniques The goal of radiation protection is to reduce the dose to patients and personnel. Dose management techniques are intended to reduce and optimize the imaging process to produce diagnostic image quality using the ALARA philosophy. These techniques are governed objectively by the guidelines and recommendations of not only the ICRP but also of various national regulatory authorities and by radiation protection organizations issuing Radiation Protection Reports. The guidelines and recommendations for dose management in radiology address the four major areas. ◼◼ Equipment design and performance. Equipment must be designed or upgraded to meet certain specifications that will allow the operator to optimize image quality while protecting patients and personnel from unnecessary radiation. These guidelines and recommendations focus on specific technical parameters such as filtration, collimation, and source‐to‐skin distance for radiographic and fluoroscopic (fixed and mobile) equipment. ◼◼ Personnel practices. These recommendations focus on the conduct of the examination using the ALARA 0004398308.INDD 10 7/8/2019 12:37:11 PM Nature and Scope of Radiation Protection 11 philosophy. For example, the primary beam must always be collimated to the size of the image receptor or smaller; technologists should not hold patients to achieve immobilization during an examination. ◼◼ Shielding. Shielding is one of three radiation protection actions intended to protect individuals from radiation exposure. Recommendations for shielding address the use of lead shields to protect radiosensitive organs such as the gonads. Additionally, walls of x‐ray rooms are lined with lead to prevent radiation from penetrating and exposing individuals outside the room. ◼◼ Education and training. Guidelines and recommendations for the safe use of radiation also address the need for operators to be educated and trained in a wide range of subjects. These subjects include radiation physics, instrumentation, radiation risks, and radiation protection, and are intended to minimize the radiation dose to patients, personnel, and members of the public. These techniques are described further in Chapter 7. The operations needed to observe ALARA include dose reduction and dose optimization. A good dictionary defines the term reduction as “reduce or diminish in size, amount, extent or number;” the term optimization refers to “an act, process, or methodology of marking something (as a design, system, or decision) as fully perfect, functional, or effective as possible.” Optimization is viewed as a much more involved process and requires a careful examination of reducing the dose so as not to compromise the diagnostic quality of the image. Optimization addresses both image quality and dose. Pregnancy: Radiation Protection Considerations This is an important topic in radiation protection for everyone working in radiology because of the sensitivity of the conceptus (any product of conception, embryo, or fetus) to radiation. 0004398308.INDD 11 7/8/2019 12:37:11 PM 12 Rad Tech’s Guide to Radiation Protection There are several major considerations with respect to in-utero exposure in radiology. It is not within the scope of this chapter to outline all of the factors relating to in-utero exposure. However, a few significant points to be noted are: ◼◼ Data suggest that, depending on the dose and gestational stage of exposure, there can be malformations and radiation‐induced childhood malignancy. ◼◼ If a patient must have an x‐ray examination (because the benefits outweigh the risks), then several precautions should be taken: ◼◼ Shielding must be used only if it will not interfere with diagnostic information. ◼◼ High‐kVp techniques and increased filtration are advocated. ◼◼ Fluoroscopy must be kept to an “absolute minimum.” ◼◼ The number of images must be kept to a minimum. ◼◼ Several factors affect dose to the fetus, including the technical factors previously mentioned. Additionally, direct exposure (fetus in the field‐of‐view) and indirect exposure (fetus outside the field‐of‐view) are significant factors. ◼◼ Fetal doses can be estimated to provide information on the risks to the fetus and on any actions to be taken. ◼◼ Following an exposure, the NCRP (Report 54) recommendations should be observed. These points are examined in Chapter 9. ◼◼ Ultrasound (rather than radiology) is now used to evaluate fetal maturation and placental localization. Several issues and concerns surround the pregnant technologist. The pregnant technologist should notify the department of her pregnancy and use a second dosimeter for the remainder of the pregnancy (under the apron at the waist level). The work schedule of a pregnant technologist may be altered. 0004398308.INDD 12 7/8/2019 12:37:11 PM 2 Diagnostic X-Rays Essential Physical Factors Chapter at a Glance X-Ray Production Mechanisms for Creating X-Rays X-Ray Spectrum Form of an X-Ray Emission Spectrum X-Ray Beam Quality and Quantity Controlling Beam Quality and Quantity X-Ray Attenuation Definition Factors Affecting Attenuation X-Ray Interactions Photoelectric Absorption Compton Scattering Increasing kV and Scatter Production X -rays are produced when high-speed electrons strike a target. In diagnostic radiology, an X-ray tube is used to produce X‐rays to image patients. The X‐ray tube consists basically of an anode and a cathode. The cathode consists of a filament that when heated emits electrons. In turn, the electrons Rad Tech’s Guide to Radiation Protection, Second Edition. Euclid Seeram. © 2020 John Wiley & Sons Ltd. Published 2020 by John Wiley & Sons Ltd. 0004398309.INDD 13 7/8/2019 12:53:43 PM 14 Rad Tech’s Guide to Radiation Protection are accelerated at high speeds to strike a small spot on the anode, called the target. The electron–target interaction results in the production of heat and X‐rays. The purpose of this chapter is to outline several physical factors relating to the basic physics of X‐ray production, X‐ray interactions with matter, and X‐ray attenuation, all of which are important to radiation protection. An understanding of how the X‐ray beam is produced, how it interacts with the patient, and what happens when the beam is transmitted through the patient is key to optimizing image quality and minimizing radiation dose. The technologist has control over several parameters that affect X‐ray production, attenuation, and interaction with the patient. This chapter is pivotal in ensuring that the technologist/ radiographer has the fundamental cognitive skills that are required for good radiation protection practices. X-Ray Production To produce X‐rays for a particular examination, the technologist sets up the appropriate voltage (kV), current (mA), and time (in seconds [s]) on the control panel. These exposure technique factors determine the type of radiation beam that will be produced by the X‐ray tube. In this section, the following points are summarized: the mechanisms by which electrons from the filament of the X‐ray tube create X‐rays; the X‐ray emission spectrum, including X‐ray beam quantity, X‐ray beam quality, and the factors affecting both; and, finally, X‐ray attenuation. Mechanisms for Creating X-Rays There are two mechanisms by which high‐speed electrons from the filament of an X‐ray tube create X‐rays. These are the characteristic and the bremsstrahlung processes, which give rise to characteristic and bremsstrahlung radiation, respectively. 0004398309.INDD 14 7/8/2019 12:53:43 PM Diagnostic X-Rays M L K – – 15 Incoming high-speed electron – Nucleus K-characteristic X-rays Ejected K-shell electron Figure 2.1 Characteristic X-rays are emitted when an inner-shell electron is ejected from the atom (ionization) and an outer-shell electron moves in to fill the vacancy in the inner shell. ◼◼ Characteristic radiation. When a high‐speed electron from the filament interacts with an inner‐shell electron of the target atom, and the electron has enough kinetic energy, then the electron will be ejected from its orbit leaving a vacancy in the orbit. An electron from an outer shell will move into the inner‐shell vacancy. This movement results in an emission of characteristic X‐rays, as shown in Figure 2.1. ◼◼ Bremsstrahlung radiation. This is the result of electrons interacting with the target nucleus rather than its electrons. The production of bremsstrahlung (brems) radiation is illustrated in Figure 2.2. When incident electrons approach the charged nucleus, they decelerate, change direction, and exit with reduced energy. This loss of energy appears in the form of radiation called brems radiation. The following points are important with respect to characteristic and brems radiation in diagnostic radiology: ◼◼ In the range of kV values used in diagnostic radiology for general radiographic and fluoroscopic procedures, most of the X‐rays emitted from the tube are brems radiation. 0004398309.INDD 15 7/8/2019 12:53:43 PM 16 Rad Tech’s Guide to Radiation Protection K-shell Incoming high-speed electron – KEx Brems radiation: E Nucleus KEY – Outgoing electron Figure 2.2 Brems radiation is emitted from the X-ray tube when high-speed electrons interact with the nucleus of the target atoms. Electrons slow down, change direction, and leave with reduced kinetic energy. This loss of energy results in brems radiation. ◼◼ In mammography, however, characteristic radiation is used, as the narrow band of energy is most useful when imaging the soft tissues of the breast. ◼◼ K‐characteristic radiation is used in radiography. ◼◼ Brems radiation has a wide range of energies suitable for all radiographic and fluoroscopic examinations. ◼◼ The output radiation from the X‐ray tube consists of both brems and characteristic radiation. If the intensity of the radiation is plotted as a function of its energy, then an X‐ray emission spectrum is the result. X-Ray Spectrum When a technologist makes an exposure for an examination, both characteristic and brems radiation are emitted from the tube. This emission is known as the X‐ray emission spectrum, which can be represented as a graph illustrating the intensity of X‐rays (number of X‐rays per unit energy) plotted as a function of the X‐ray energy. 0004398309.INDD 16 7/8/2019 12:53:43 PM Diagnostic X-Rays 17 Form of an X-Ray Emission Spectrum ◼◼ The general form of an X‐ray emission spectrum is shown in Figure 2.3. ◼◼ Two spectra are shown: 1. The brems or continuous spectrum. 2. The characteristic or discrete spectrum. An understanding of both of these spectra helps the technologist realize how exposure technique factors and filtration can affect image quality and radiation dose. ◼◼ The area under the curve represents the number of pho- Number of X-ray photons per unit energy tons in the X‐ray beam. A greater area indicates more photons, thus a higher dose. The area is also referred to as the X‐ray quantity. ◼◼ The energy distribution of the beam is shown on the horizontal axis and is expressed in keV. The term X‐ray quality is used to describe the energy distribution, thus the shape of the curve. A Bremsstrahlung spectrum (continuous spectrum) Characteristic spectrum (discrete spectrum) B Energy (keV) Figure 2.3 The form and shape of the brems and characteristic X-ray spectra. 0004398309.INDD 17 7/8/2019 12:53:43 PM 18 Rad Tech’s Guide to Radiation Protection X-Ray Beam Quality and Quantity The intensity of the beam from the tube can be described in terms of both the quantity and quality. The quantity and quality of the beam emanating from the X‐ray tube affect the dose to the patient. ◼◼ X‐ray quantity, also referred to as radiation exposure, refers to the number of photons in the beam. More photons increase the dose to the patient. Numerous factors determine X‐ray quantity. ◼◼ X‐ray quality refers to the energy or penetrating power of the photons in the beam. The beam consists of both high‐energy and low‐energy photons. Numerous factors affect beam quality. Controlling Beam Quality and Quantity There are several factors that affect the quality and quantity of the X‐ray beam. However, few are under the direct control of the technologist. The factors affecting quality and quantity are: ◼◼ kV. which is under the direct control of the technolo- gist. The penetration of the beam and the beam quality is greater as the kV increases. High‐kV techniques result in a low dose. The beam intensity is directly proportional to the square of the ratio of the kV change, that is (kVnew/ kVold)2. If the kV is doubled, then the intensity increases by a factor of four. This factor means that by increasing the kV, the quantity can be increased. Increasing the kV by 15% is comparable to doubling the mAs. ◼◼ mA/mAs, which are under the direct control of the technologist. mA/mAs affects the quantity of radiation in that the quantity is proportional to the mA. If the mA is doubled, then the quantity is doubled, and the 0004398309.INDD 18 7/8/2019 12:53:43 PM Diagnostic X-Rays 19 dose is increased by a factor of two. The same applies to the mAs. ◼◼ Filtration. Filtration affects both the quality and quantity of the beam. A filter is always inserted in the X‐ray beam to remove low‐energy photons. This reduces the quantity and, as a result, the mean energy of the beam increases. The beam becomes more penetrating or harder. Thicker filters reduce the quantity of the beam, but increase beam quality. A filter is intended to protect the patient by removing these low‐energy photons. ◼◼ Target material. Target materials with higher atomic numbers increase both the quantity of photons slightly and the quality (energy) of the beam. Tungsten produces a significantly more efficient spectrum than molybdenum. The technologist has no control over this parameter. ◼◼ Type of generator. The X‐ray generator provides power to energize the X‐ray tube to produce X‐rays. This generator determines the voltage waveform to the tube. Three types of generators are available: single‐phase, three‐ phase, and high‐frequency generators. State‐of‐the‐art X‐ray equipment uses high‐frequency generators, which are more efficient since they produce a greater quantity of photons (area under the curve) with higher effective energies (greater quality) than single‐ and three‐phase generators. This means that the dose can be reduced when using high‐frequency generators by appropriately adjusting exposure technique factors (e.g. high‐kV techniques can be used). ◼◼ Source‐to‐image receptor distance (SID). This is under the direct control of the technologist. The SID affects the quantity of photons but has no effect on the quality. The quantity is affected by the inverse square law, which states that the intensity (quantity) is inversely proportional to the square of the distance. If the distance is increased, then the quantity decreases by l/d2. 0004398309.INDD 19 7/8/2019 12:53:43 PM 20 Rad Tech’s Guide to Radiation Protection X-Ray Attenuation Definition When a beam of X‐rays passes through matter, it is attenuated (reduced in intensity) before it reaches the image receptor. ◼◼ Attenuation is the reduction in the intensity of the beam as it passes through any material. ◼◼ The materials that are of importance in radiology are, of course, the X‐ray tube filter and the patient. ◼◼ The reduction in intensity is a result of absorption and deflection of photons from the radiation beam. ◼◼ Absorption of photons produces a greater dose to the patient. ◼◼ Increased attenuation produces more absorption, thus increasing the dose to the patient. ◼◼ A measure of the radiation quantity attenuated by a given thickness of material is defined as the attenuation coefficient. ◼◼ The linear attenuation coefficient (μ) is the fractional reduction of the radiation per unit thickness of the material traversed. ◼◼ Although μ is a measure of per unit length attenuation, it can also be expressed as per unit mass of the absorbing material. This is the mass attenuation coefficient, which is equal to μ divided by the density (ρ) of the material. The unit of μ/ρ is centimeter2 per gram (cm2/g). ◼◼ The attenuation of a homogeneous beam (all photons have the same energy or are monochromatic) of X‐rays or gamma rays is shown in Figure 2.4. The following points are important: ◼◼ Equal thicknesses of absorber remove equal amounts of radiation (Figure 2.4a) ◼◼ The attenuation is exponential (Figure 2.4b) and can be described by the equation: 0004398309.INDD 20 7/8/2019 12:53:43 PM Diagnostic X-Rays (a) 21 Attenuation of a HOMOGENEOUS beam of radiation Beam quantity 1000 Photons IN 32 Photons OUT Beam quality (40 kVp) (40 kVp) Beam quantity Beam quality 1 cm (b) I0 I I = I0e–μx Figure 2.4 Exponential attenuation of a homogeneous (monochromatic) beam of radiation in which all the photons have the same energy. I Io e x where Io = intensity of the incident photons I = intensity of the transmitted photons e = base of the natural logarithm x = thickness of the material ◼◼ The X‐ray beam from the X‐ray tube is a heterogeneous or polychromatic beam in which the photons have different energies, and the attenuation is somewhat different from a monochromatic or homogeneous beam. ◼◼ The attenuation of a heterogeneous beam is illustrated in Figure 2.5. The following points are important: ◼◼ Equal thicknesses of material remove different amounts of radiation. ◼◼ Low‐energy photons are attenuated more rapidly compared with high‐energy photons. This event changes both the quantity and quality of the beam. 0004398309.INDD 21 7/8/2019 12:53:44 PM 22 Rad Tech’s Guide to Radiation Protection Beam quantity Attenuation of a HETROGENEOUS beam of radiation Beam quantity 1000 Photons IN 32 Photons OUT (40 kVp) (57 kVp) Beam quality 1 cm Beam quality Figure 2.5 Attenuation of a heterogeneous beam of radiation. See text for further explanation. ◼◼ The beam quantity decreases and the beam quality increases. That is, the mean energy of the photons increases. This increase is referred to as beam hardening, a term used to indicate that the beam is more penetrating. Factors Affecting Attenuation Since attenuation affects the dose to the patient through the absorption process, it is necessary to examine the factors that increase attenuation (more patient dose) and factors that decrease attenuation (less patient dose). These factors include: ◼◼ Thickness of the absorbing material. In general, the thicker the material, the greater the attenuation. ◼◼ Density (mass per unit volume). As the density of the material increases, attenuation increases. ◼◼ Atomic number (Z) or number of protons in the nucleus. As atomic number increases, attenuation increases. Contrast agents – barium and iodine compounds – increase attenuation and are used to visualize blood vessels and the gastrointestinal track because their atomic numbers are different from the surrounding soft tissue. These compounds attenuate more radiation rendering them visible on the image. 0004398309.INDD 22 7/8/2019 12:53:44 PM Diagnostic X-Rays 23 ◼◼ Beam energy. This factor is determined by the kV used to image the material (patient). ◼◼ Low kV results in more absorption of the beam (increased attenuation), thus a higher dose to the patient. ◼◼ High kV results in more transmission of the beam through the patient (less absorption), thus a lesser dose to the patient. To understand how beam energy and attenuation are related, it is necessary to explain what occurs when X‐rays interact with matter. X-Ray Interactions One of the goals of radiology is to optimize the dose to the patient without compromising image quality. It is the nature of the interactions of radiation with matter that determines not only image contrast but also the dose to the patient. There are several interactions of radiation with matter, including Rayleigh (coherent) scattering, photoelectric absorption, Compton scattering, and pair production. Among these, the photoelectric absorption and Compton scattering are the most important attenuation mechanisms in diagnostic ­radiology. Therefore, only these two are presented in this chapter. The others do not occur with any noticeable significance in diagnostic radiology. The physics of the interactions will not be described but, rather, a basic overview is presented to demonstrate how these two interactions relate to dose to the patient, as well as beam energy. Photoelectric Absorption Photoelectric absorption (also referred to as the photoelectric effect) is shown in Figure 2.6. The following points are noteworthy: ◼◼ The incident photon interacts with an inner‐shell (K or L) electron (tightly bound). 0004398309.INDD 23 7/8/2019 12:53:44 PM 24 Rad Tech’s Guide to Radiation Protection M L Photoelectron – K Incident photon – Nucleus Figure 2.6 Photoelectric absorption is an attenuation mechanism whereby an incident photon interacts with inner-shell electrons, ejecting them from the atom. See text for further explanation. ◼◼ The photon is completely absorbed and the elec- tron is ejected from the atom. This electron is called a photoelectron. ◼◼ The absorption of the incident photons in this interaction increases the dose to the patient as they do not pass through the patient and reach the image receptor. ◼◼ The probability that the photoelectric effect will occur depends on the photon energy (E) and the atomic number (Z) of the absorbing material. ◼◼ The probability is directly proportional to Z3 and inversely proportional to E3. ◼◼ At low beam energies (low‐kV techniques) the photoelectric effect predominates and the patient dose increases. However, image contrast is greater in materials with high atomic numbers. Compton Scattering Another X‐ray interaction that is significant in diagnostic radiology is Compton scattering, as shown in Figure 2.7. In Compton scattering: ◼◼ Incident photons interact with free electrons, which are loosely bound electrons in the outer shell of the atom. ◼◼ The incident photon is scattered in a new direction with energy less than that of the incident photon. 0004398309.INDD 24 7/8/2019 12:53:44 PM Diagnostic X-Rays 25 Compton – electron Nucleus λ1 Incident X-ray photon – θ Angle of deflection λ2 Scattered X-ray photon Figure 2.7 Compton interaction or scattering is an attenuation mechanism whereby an incident photon interacts with an outer-shell electron and ejects it from the atom. The incident photon loses its energy and changes direction of travel. This deflected photon is the scattered photon that may reach the image detector and destroy image contrast. ◼◼ The incident photon also ejects the electron from its orbit. This electron is called a recoil or scattered electron. ◼◼ The scattered photons (scattered radiation) reach the film and degrade image contrast. Compton scattering produces most of the scattered radiation in diagnostic radiology. ◼◼ The probability that a Compton interaction will occur depends on the number of outer‐shell electrons and the photon energy (E). ◼◼ Compton interaction is directly proportional to the number of outer‐shell electrons and inversely proportional to E. Characteristics of a Compton interaction are: ◼◼ As the number of outer‐shell electrons (loosely bound electrons) increases, Compton scattering increases. ◼◼ As the X‐ray energy increases, the probability of Compton interaction decreases. 0004398309.INDD 25 7/8/2019 12:53:44 PM 26 Rad Tech’s Guide to Radiation Protection ◼◼ The probability of Compton interaction relative to photoelectric absorption increases. ◼◼ The probability of penetration of the beam through the absorber increases. ◼◼ In radiography and fluoroscopy, the patient is the major source of scattered radiation. Technologists and radiologists must protect themselves from exposure to scatter by remaining in the control booth or by wearing protective aprons during the exposure. Increasing kV and Scatter Production High‐kV techniques are used in diagnostic radiology to penetrate the anatomy (as well as contrast agents such as barium) and to reduce the dose to the patient. High‐kV techniques produce images with poor image contrast resulting from the increasing scatter that reaches the image detector. ◼◼ Scatter production in the patient is decreased because the probability of Compton interaction decreases with increasing kV. ◼◼ The forward scatter leaving the patient and reaching the image detector increases because: ◼◼ The fraction of the total scatter produced, traveling in a forward direction, increases as the kV rises. ◼◼ The mean energy of the scattered radiation increases, thus less of it is absorbed by the patient. Therefore, the major reason for an increase in scatter at the image detector is the increase in the mean energy of the scatter. 0004398309.INDD 26 7/8/2019 12:53:44 PM 3 Radiation Quantities and Units Chapter at a Glance Sources of Radiation Exposure Types of Exposure Occupational Exposure Medical Exposure Public Exposure Quantities and Units for Quantifying Ionizing Radiation Exposure KERMA Absorbed Dose f-Factor Linear Energy Transfer Quantities and Units for Quantifying Biologic Risks Dose Equivalent Radiation Weighting Factor Rad Tech’s Guide to Radiation Protection, Second Edition. Euclid Seeram. © 2020 John Wiley & Sons Ltd. Published 2020 by John Wiley & Sons Ltd. 0004398310.INDD 27 7/8/2019 12:56:31 PM 28 Rad Tech’s Guide to Radiation Protection Equivalent Dose Effective Dose Tissue Weighting Factor Radiation Measurement Ionization Chamber Film Dosimetry Thermoluminescent Dosimetry Optically Stimulated Luminescence (OSL) Dosimetry Wearing a Personnel Dosimeter H uman beings are exposed to several sources of radiation and subject to different types of radiation exposure. Quantifying ionizing radiation and biologic risks demands an understanding of radiation quantities and the units associated with each of them. The purpose of this chapter is to identify the two major sources of radiation exposure and define the situations in which individuals are exposed to radiation. In addition, several radiation quantities and their units are highlighted. These topics are important to the technologist for several reasons: ◼◼ Annual dose limits for individuals are based on the types of exposure. ◼◼ Dose magnitudes from various radiological procedures are often compared with those from natural background radiation exposure. ◼◼ Dose limits demand a clear understanding of radiation quantities and their associated units. ◼◼ Radiation quantities and their units are essential ingredients when quantifying ionizing radiation and biologic risks. ◼◼ Measuring and reporting patient dose in radiology require the intelligent use of these quantities. 0004398310.INDD 28 7/8/2019 12:56:31 PM Radiation Quantities and Units 29 Sources of Radiation Exposure There are two main sources of radiation exposure: ◼◼ Natural radiation sources ◼◼ Radiation sources of human origin Natural radiation sources comprise three major categories: cosmic radiation, earth sources (terrestrial radiation), and internal sources. ◼◼ Among the natural sources, radon contributes the high- est exposure to the population. Specifically, radon‐222 (222Rn) is a naturally occurring radioactive gas that arises from the radioactive decay of radium‐226 (226Ra). Radon exposure is particularly important to the public since its intensity depends on where an individual lives. Radon gas can enter a building. Breathing radon gas can expose the lungs to alpha particles, which the gas emits. When the level of radon gas exceeds 4 picocuries per liter (pCi/L) in a building, the United States Environmental Protection Agency (EPA) recommends that efforts be made to eliminate or reduce this exposure. ◼◼ Cosmic radiation includes solar and galactic radiation (e.g. gamma rays, high‐energy protons, neutrons). Cosmic radiation intensity depends on latitude and altitude and is greatest at the poles and least at the equator. Additionally, cosmic radiation increases with altitude. ◼◼ Earth sources include radiation from the air, terrestrial radiation, radiation from buildings, and endogenous radiation. The last source refers to radiation arising from several internal body sources, such as carbon‐14, potassium‐40, rubidium‐87, and strontium‐90. Sleeping with a partner will increase an individual’s exposure. Radiation sources of human origin, conversely, consist of several sources, including medical X‐rays, nuclear medicine, 0004398310.INDD 29 7/8/2019 12:56:31 PM 30 Rad Tech’s Guide to Radiation Protection consumer products (e.g. smoke alarms), and other sources such as fall‐out from nuclear testing. ◼◼ Medical X‐ray exposure represents the greatest source of exposure to the population. ◼◼ Nuclear medicine examinations result in the second largest radiation source of human origin compared with all others. Exposures from medical X‐rays and nuclear medicine procedures constitute medical exposure, compared with other types of exposure such as occupational exposure and public exposure. Types of Exposure The International Commission on Radiological Protection (ICRP) identifies three situations in which individuals are exposed to radiation. Occupational Exposure This situation refers to all exposures received in the workplace by radiologic technologists. All exposures received when working in radiography, fluoroscopy, mobile, and operating room radiography, computed tomography, and angiography constitute occupational exposure. Occupational exposure excludes medical exposure. Medical Exposure This situation includes exposures from medical and therapy ­procedures for diagnosis and treatment, respectively. It also includes exposures resulting from individuals assisting patients having diagnostic or therapeutic examinations. It does not include radiation scattered from patients having examinations or occupational exposure of staff members. 0004398310.INDD 30 7/8/2019 12:56:31 PM Radiation Quantities and Units 31 Public Exposure The ICRP (2007) states that: Public exposure encompasses all exposures other than occupational and medical exposures. The component of public exposure due to natural sources is by far the largest, but this provides no justification for reducing the attention paid to smaller but more readily controlled exposures to artificial sources (p. 34). Quantities and Units for Quantifying Ionizing Radiation There are three radiation quantities: exposure, absorbed dose, and effective dose. The first two refer to the radiation, and the third (effective dose) relates to the biologic risk of the radiation absorption. In this section, we focus only on quantities and units for quantifying ionizing radiation. Recently, the ICRP began using the International System of Units (SI units) for radiation quantities. SI units are now used in several countries, including the United Kingdom (UK), Canada, and Australia. In the United States, the National Council of Radiation Protection and Measurements (NCRP) made the following statement with respect to the use of SI units in radiation protection and measurements: “After 1989, it is recommended that SI units be used exclusively.” SI units are used throughout this book. Exposure Exposure is a radiation quantity referring to the intensity of radiation. Exposure: ◼◼ Can be measured using an ionization chamber, which contains a volume of air. ◼◼ Ionizes the air in the chamber. ◼◼ Is the total change liberated in a cubic centimeter of air. 0004398310.INDD 31 7/8/2019 12:56:31 PM 32 Rad Tech’s Guide to Radiation Protection ◼◼ Is measured in coulombs per kilogram (C/kg) in the SI system and in roentgens (R) in the old system of units. ◼◼ 1R = 2.58 × 10 4 C/kg; 1C = 1.6 × 1019 electrons. ◼◼ Follows the inverse square law, which states that the intensity of radiation decreases inversely as the square of the distance. If distance from the source of exposure is increased by a factor of three, then the exposure is decreased by a factor of nine: ◼◼ Is equal to the exposure rate multiplied by time. The exposure rate is the exposure per unit time. KERMA KERMA is a quantity that characterizes the radiation field. ◼◼ KERMA is an acronym for kinetic energy released per unit mass. ◼◼ KERMA quantifies the energy transferred from the radi- ation beam to charged particles (protons and electrons) in matter. ◼◼ The unit of KERMA is joules per kilogram (J/kg). ◼◼ KERMA may replace the quantity exposure in the SI system. Absorbed Dose Absorbed dose is another quantity to quantify ionizing radiation. ◼◼ Absorbed dose (D) is the energy deposited in an absorbing medium from ionizing radiation. (Absorbed dose is a measure of the amount of energy absorbed.) ◼◼ The SI unit for absorbed dose is the gray (Gy); the old unit is the rad (radiation absorbed dose). ◼◼ 1 Gy = 100 rad. ◼◼ 1 rad = 10 mGy. ◼◼ 1 Gy of absorbed dose is equal to 1 J of energy deposited per kilogram of absorbing medium. ◼◼ Biologic effects are associated with the amount of absorbed dose. 0004398310.INDD 32 7/8/2019 12:56:32 PM Radiation Quantities and Units 33 f-Factor When it is necessary to calculate the absorbed dose (D) given only the exposure, the f‐factor is used. ◼◼ D = f × Exposure. ◼◼ f converts roentgens to rads. ◼◼ For radiology, the f‐factor for air and soft tissues is approx- imately one, although it ranges from four (low energy) to one (high energy) for bone. Linear Energy Transfer The linear energy transfer (LET) is a physical factor quantifying the radiation beam. ◼◼ LET is the rate at which the radiation transfers energy to surrounding tissues. ◼◼ The unit of LET is kilo electron volt per micrometer (keV/μm). ◼◼ The LET for X‐rays is 3.0 keV/μm and 100 keV/μm for 5‐ MeV alpha particles. ◼◼ As LET increases, bioeffectiveness increases. Quantities and Units for Quantifying Biologic Risks Radiation absorption in biologic systems can lead to ­excitation and ionization. Both excitation and ionization lead to the production of free radicals, which subsequently produce ­biologic damage. Several quantities are used to quantify biologic risks of radiation exposure; these include dose equivalent, equivalent dose, and effective dose. The current quantity is the Effective Dose (E). 0004398310.INDD 33 7/8/2019 12:56:32 PM 34 Rad Tech’s Guide to Radiation Protection Dose Equivalent The dose equivalent (H) is a quantity defined for radiation protection purposes. Since different sources of radiation have different efficiencies in producing biologic damage, a quantity is required to address the differences in bioeffectiveness. The dose equivalent represents this quantity. ◼◼ Dose equivalent is equal to the absorbed dose (D) multiplied by a quality factor (Q), which depends on the LET of the radiation. H DQ ◼◼ The SI unit of H is the sievert (Sv); the old unit is the rem (rad equivalent man). ◼◼ The badges worn by technologists record occupational exposure in millisieverts (mSv). ◼◼ The sievert is related to absorbed dose as follows: Sievert Gray Radiation Weighting Factor WR ◼◼ 1 Sv = 100 rem ◼◼ 1 mSv = 100 mrem ◼◼ 10 mSv = 1 rem ◼◼ For the sake of simplicity (in radiology), 1Roentgen 1rad 1rem ◼◼ In the SI system, 2.58 10 4 C / kg 0.01Gy 0.01Sv Radiation Weighting Factor Bioeffects of radiation depend not only on the absorbed dose (D) but also on the type and energy of the radiation. ◼◼ Radiation weighting factor (W ) is 1 for X‐rays and gamma R rays, 5 for high‐energy protons, and 20 for alpha particles and fission fragments. 0004398310.INDD 34 7/8/2019 12:56:32 PM Radiation Quantities and Units 35 Equivalent Dose In 1990, the ICRP revised its radiation protection recommendations and the term dose equivalent (H) was replaced by the term equivalent dose (HT). While H is the weighted absorbed dose at a point, HT is the weighted absorbed dose in tissues or organs. ◼◼ H = ΣW ·D T R TR ◼◼ The above is read as the equivalent dose is equal to the sum of the weighted absorbed doses. DTR is the absorbed dose averaged over the tissue or organ, T, for the type of radiation, R. Effective Dose The effective dose (E) was previously referred to as the effective dose equivalent (HE). ◼◼ E is the equivalent dose weighted for the type of tissue (organ). ◼◼ E is used to quantify the different risks from partial body exposure compared with risks from an equivalent whole‐ body dose. ◼◼ E = ΣW ·H , where W is the tissue weighting factor. T T T ◼◼ The SI unity E is sievert (Sv); the old unit is the rem. ◼◼ The dose limits recommended for occupational, public, students in training, and the embryo or fetus are expressed as E. ◼◼ If the effective dose for an upper gastrointestinal tract examination is 2.45 mSv, then this value means that the risk from an upper gastrointestinal tract examination is equivalent to the risk of an exposure dose of 2.45 mSv to the whole body. Tissue Weighting Factor Bioeffects depend not only on the absorbed dose and type and energy of the radiation, but also on the type of tissue. 0004398310.INDD 35 7/8/2019 12:56:32 PM 36 Rad Tech’s Guide to Radiation Protection ◼◼ The tissue weighting factor, W , provides data on the T relative contribution of the tissue or organ to the total biologic response from whole‐body irradiation. ◼◼ The W for the gonads, active bone marrow, breast, and thyT roid, for example, are 0.20, 0.12, 0.05, and 0.05, respectively. Radiation Measurement There are a number of tools currently available for measuring and monitoring the amount of radiation to an individual. Of ­relevance to diagnostic radiology are the ionization chamber, film dosimetry, thermoluminescent dosimetry (TLD), and optically stimulated luminescence (OSL) dosimetry. Ionization Chamber The ionization chamber comprises a gas‐filled chamber and is used to measure radiation exposure. ◼◼ When radiation falls on the chamber, the gas ionizes to produce ions, which are collected and counted. ◼◼ The total charge (Q coulombs) determines the exposure expressed in Roentgens or C/kg. ◼◼ Ionization chambers are used as dosimetry devices to measure the output from an X‐ray tube. These chambers are also used in automatic exposure timing. ◼◼ A pocket ionization chamber can be used for personnel dosimetry (i.e. to measure occupational exposures). Film Dosimetry Film dosimetry is an older approach used to monitor occupational exposures in the form of a film badge. Some places may still be using film dosimetry! In any case: ◼◼ The film badge consists of small X‐ray films placed bet- ween special filters to detect beta, gamma, and X‐rays. 0004398310.INDD 36 7/8/2019 12:56:32 PM Radiation Quantities and Units 37 ◼◼ These badges can detect occupational exposure at or above 0.1 mSv (10 mrem) and are not sensitive enough to detect lower levels of exposure. ◼◼ Film dosimetry is being replaced by TLD. Thermoluminescent Dosimetry Thermoluminescent dosimetry can be used to measure patient exposures and to monitor personnel occupational exposures. ◼◼ TLD is based on thermoluminescence. ◼◼ Lithium fluoride (LiF) chips are used in diagnostic radiology. ◼◼ When exposed to X‐rays, electrons in the LiF are raised to another energy level and are trapped there until the TLD chip is heated. This heating causes the electrons to return to their original orbits causing the emission of light. The amount of light emitted is directly proportional to the radiation exposure. ◼◼ TLD can measure doses from 0.1 mGy (10 mrad) to approximately 10 Gy (1000 mrad). Optically Stimulated Luminescence (OSL) Dosimetry The OSL dosimeter was developed in the 1990s by Landauer for the purpose of monitoring staff in an environment in which they are exposed occupationally. The dosimeter contains an aluminum oxide (Al2O3) detector. There are three important steps to using this dosimeter. First, when the Al2O3 detector is exposed to radiation, electrons are raised into an excited state. Secondly, during processing, a laser light stimulates the electrons trapped in the excited state and causes them to return to their ground state. This process results in light being emitted. Finally, this light is measured and is found to be proportional to the dose falling upon the OSL. The OSL as a personnel monitor 0004398310.INDD 37 7/8/2019 12:56:32 PM 38 Rad Tech’s Guide to Radiation Protection is more sensitive that the TLD dosimeter, since it can detect very small doses, such as 10 μGy, for example. Wearing a Personnel Dosimeter In radiography and fluoroscopy, technologists must wear personnel dosimeters to record their occupational exposures in millisieverts. ◼◼ In radiography, the dosimeter can be worn at the level of the waist, at the level of the collar in the upper chest area, or on the anterior surface of the individual. ◼◼ In fluoroscopy, when a protective apron must be worn, the NCRP (1989) states: When the apron is worn, a decision must be made as to whether to wear one or more than one dosimeter. If only one is worn and it is worn under the apron, it can represent the dose to most internal organs, but it may underestimate the dose to the head and neck (including the thyroid gland). If only one is worn and it is worn at the collar, it may represent the dose to the organs contained in the head and neck, but it may overestimate the dose to the organs in the trunk of the body (p. 49). ◼◼ Health Canada Radiation Safety Code SC 35 (2008) states that for diagnostic radiology, the dosimeter must be worn under the apron; and when the radiation levels are considered to be high, additional dosimeters should be worn on the extremities. As noted by Bushong (2017), “we assume the occupational ­effective dose to be 10% of the monitor dose. Assuming the effective dose of 10% of the occupational monitor dose is conservative. In actual fact, it is something less than 10%.” 0004398310.INDD 38 7/8/2019 12:56:32 PM 4 Basic Radiobiology Chapter at a Glance What Is Radiobiology? Essential Physics and Chemistry Basic Physics Basic Chemistry Fundamental Concepts of Radiobiology Types of Bioeffects Radiosensitivity Dose-Response Relationships The LNT Model Debate Concerns Radiation Effects on DNA and Chromosomes Target Molecule Target Theory Direct and Indirect Effects DNA Damage Chromosome Damage Deterministic Effects (Early Effects of Radiation) LD50/60 Acute Radiation Syndromes Rad Tech’s Guide to Radiation Protection, Second Edition. Euclid Seeram. © 2020 John Wiley & Sons Ltd. Published 2020 by John Wiley & Sons Ltd. 0004398311.INDD 39 7/8/2019 12:58:24 PM 40 Rad Tech’s Guide to Radiation Protection Stochastic Effects (Late Effects of Radiation) Tissue Effects Life-Span Shortening Radiation-Induced Cancers Hereditary Effects Radiation Exposure During Pregnancy I t is well known that radiation can cause biologic damage, as derived from both animal and human studies. In diagnostic radiology, the benefits associated with radiation exposure far outweigh any risks to the patient. These radiation risks (bioeffects) have received increasing attention since patients received more radiation from diagnostic X-ray examinations than from any other source of radiation exposure (Chapter 3). The purpose of this chapter is to review the fundamental concepts relating to the manifestation of biologic damage and to describe the early and late effects of radiation exposure. Specifically, radiobiology will be defined and sources of data on the bioeffects of radiation will be identified. This section will be followed by a description of radio sensitivity, dose response models, effects of radiation on cells and water, direct and indirect action of radiation, and the target theory. Finally, the chapter will conclude with a summary of the early and late effects of radiation. It is essential that technologists have a firm understanding of these topics because: ◼◼ Current radiation protection standards and recommen- dations are based on biologic effects. ◼◼ The dose delivered to the patient in radiology can vary from low, to moderate-to-high, depending on the type of examination. ◼◼ Dose-response models used in diagnostic radiology suggest that there is no risk-free dose of radiation. 0004398311.INDD 40 7/8/2019 12:58:24 PM Basic Radiobiology 41 What Is Radiobiology? Radiation transfers energy to biologic systems. The energy is absorbed and subsequently produces a sequence of events leading to biologic expression of harm. ◼◼ Radiobiology is the study of effects of radiation on bio- logic systems. The effects occur at the: ◼◼ Molecular level and include physical processes such as ionization and excitation of atoms, and chemical interactions such as the production and reaction of free radicals. ◼◼ Cellular level, where damage to DNA and chromosomes occurs, leading to damage at the tissue and organ levels (e.g. atrophy). ◼◼ Whole-body levels, where the responses are categorized as early and late effects. This chapter reviews the mechanisms leading to these effects. Essential Physics and Chemistry Biologic systems are made up of atoms. The interaction of radiation with a living system requires an understanding of a number of topics in physics and chemistry. Basic Physics The physics topics that are of relevance to radiobiology and are of importance to technologists in diagnostic radiology include atomic structure, the nature and properties of X-rays, ionization, excitation, linear energy transfer (LET), and relative biologic effectiveness (RBE). 0004398311.INDD 41 7/8/2019 12:58:24 PM 42 Rad Tech’s Guide to Radiation Protection It is not within the scope of this text to describe any of these in detail; the student must refer to radiological physics textbooks for elaboration. The following points, however, are noteworthy: ◼◼ The atom consists of a nucleus positioned at the center of electrons, which occupy specific orbits around the nucleus. Electrons close to the nucleus are tightly bound while electrons far away from the nucleus are loosely bound and can easily be removed from the atom (ionization). ◼◼ The nature of X-rays in terms of production and interaction with matter was the subject of Chapter 2. Essentially, X-rays can produce ionization and excitation of atoms in biologic systems. ◼◼ Ionization is the removal of an electron from an atom. Ionization results in ion pairs, the electron that has been removed and the positively charged atom remaining. Outer-shell electrons are easily removed from the atom, as they are loosely bound to the nucleus. ◼◼ Excitation is a process by which electrons are transferred into orbital levels farther away from the nucleus as a result of energy absorption. Electrons are not removed from the atom. ◼◼ Both ionization and excitation can lead to bioeffects. However, the mechanism of excitation is not fully understood. ◼◼ Linear Energy Transfer (LET) is the efficiency of radiation to produce ionization and excitation. Specifically, LET measures the rate at which energy is transferred from the radiation to the living system. The units of LET are kilo-electron volt per micrometer of length in soft tissue. As LET increases, biologic damage increases. The LET for X-rays used in radiology is approximately 3.0 keV/μm; for alpha particles, the value is 300 keV/μm. ◼◼ Relative Biologic Effectiveness (RBE) is the efficiency with which different types of radiation can cause damage to biologic systems. Specifically, the RBE is a ratio of a standard (200–250 kV X-rays) radiation dose required to 0004398311.INDD 42 7/8/2019 12:58:24 PM Basic Radiobiology 43 produce a given biologic effect to the test radiation dose required to produce the same effect. The RBE for diagnostic X-rays is 1.0. As LET increases, RBE increases since high LET produces more ionization compared with low LET radiation. Basic Chemistry In diagnostic radiology, most of the interactions of radiation and the patient occur with water, since the body contains 70–85% water. This interaction results in ionization of water, forming ion pairs and free radicals. ◼◼ Radiolysis of water refers to the breakdown of water by radiation leading to the followingchemical reactions: ◼◼ H O + radiation → H O+ + e− 2 2 ◼◼ e− + H O → H O− 2 2 ◼◼ Two ions (H O+ and H O −) are the by-products of the 2 2 initial interaction. Each of these two ions is unstable and exists for only a short time. Each will dissociate as follows: ◼◼ H O+ → H+ + OH 2 ◼◼ H O− → H + OH− 2 ◼◼ Now, there are two ions: a hydrogen ion (H+) and a hydroxyl ion (OH−); and two free radicals: a hydroxyl free radical (OH ) and a hydrogen free radical (H ). ◼◼ A free radical, symbolized by a dot (●), as shown in the above reactions, is an atom or a molecule with an unpaired electron in the outermost orbit. ◼◼ Free radicals are highly unstable chemical species and can react to form other chemical species that are harmful to the cell. ◼◼ Two ions, H+ and OH−, can recombine as follows: ◼◼ H+ + OH+ → H O 2 ◼◼ Free radicals can also recombine as follows: ◼◼ H + OH → H O 2 ● ● ● ● 0004398311.INDD 43 ● ● 7/8/2019 12:58:24 PM 44 Rad Tech’s Guide to Radiation Protection ◼◼ In the last two reactions, water is formed and there is no damage to the cell. However, free radicals can react as follows to form other molecules that are toxic to the cell: ◼◼ OH + OH → H O 2 2 ◼◼ H + O → HO 2 2 ◼◼ H O is hydrogen peroxide, which is toxic to the cell. 2 2 ◼◼ HO is hydroperoxyl free radical, which is highly reac2 tive and can combine with biologic macromolecules to produce more and more free radicals. ● ● ● ● ● Fundamental Concepts of Radiobiology There are several concepts of radiobiology that are important to the technologist and that provide a foundation for a good understanding of the bioeffects of radiation. Types of Bioeffects Bioeffects can be stochastic or deterministic effects: ◼◼ Stochastic effects are those for which the probability of occurrence increases with dose and for which there is no threshold dose. Any dose of radiation, however small, has the potential to cause biologic harm. There is no riskfree dose. ◼◼ Deterministic effects are those for which the severity of the effect increases with increasing dose and for which there is a threshold dose. Bioeffects can also be somatic and genetic effects: ◼◼ Somatic effects are those that occur in the individual exposed to the radiation. ◼◼ Genetic effects are hereditary effects and occur in the off- spring of the individual exposed to radiation. 0004398311.INDD 44 7/8/2019 12:58:24 PM Basic Radiobiology 45 Additionally, bioeffects can be discussed as early and late effects. ◼◼ Early effects appear minutes, hours, days, weeks, or months after exposure to high doses of radiation. Early effects are deterministic effects. ◼◼ Late effects occur years after exposure to low doses of radiation. Late effects are stochastic effects. Early and late effects of radiation are reviewed further in a later section of this chapter. Radiosensitivity The radiation quantity (effective dose) takes into consideration the sensitivity of tissues to radiation exposure. This sensitivity is referred to as radiosensitivity. In 1906, Bergonie and Tribondeau, two French scientists, performed experiments to demonstrate this radiosensitivity of various tissues. Their results generated the law of Bergonie and Tribondeau, which indicates the following: ◼◼ Immature cells (stem cells) are more radiosensitive than mature cells (end cells). ◼◼ Radiosensitivity is directly proportional to the prolifera- tion rate for cells and the growth rate for tissues. As both rates increase, radiosensitivity increases. ◼◼ Young tissues and organs are more radiosensitive than older tissues and organs. As noted by Bushong, this law “serves to remind us that the fetus is considerably more sensitive to radiation exposure than the child or the mature adult” (2017). Radiosensitivity also varies with the phases of the cell cycle as follows: ◼◼ The most radiosensitive phase is mitosis (M), which includes prophase, metaphase, anaphase, and telophase. ◼◼ G -phase (post-DNA synthesis) is also extremely sensitive. 2 0004398311.INDD 45 7/8/2019 12:58:24 PM 46 Rad Tech’s Guide to Radiation Protection ◼◼ The most radioresistant phase is the S-phase (DNA- synthesis phase), Certain cell types are more radiosensitive than others. For example, ◼◼ Lymphocytes, spermatogonia erythroblast, and the crypt cells of the gastrointestinal tract are extremely radiosensitive. ◼◼ Endothelial cells, osteoblasts, and fibroblasts, for example, have moderate radiosensitivity. ◼◼ Muscle cells and nerve cells have low radiosensitivity. Radiosensitivity for tissues and organs is as follows: ◼◼ Lymphoid tissue, bone marrow, and the gonads have a high level of radiosensitivity. ◼◼ The skin, gastrointestinal tract, cornea, growing bone, kidney, liver, and thyroid are moderately radiosensitive. ◼◼ Muscle, brain tissue, and the spinal cord have a low level of radiosensitivity. Dose-Response Relationships A dose-response relationship shows the relationship between a biologic response (bioeffect) as a function of radiation dose. Two popular linear relationships include: ◼◼ Linear dose-response relationship without a threshold. This relationship shows that as the dose increases, the ­biologic response increases. This relationship also indicates that there is no risk-free dose (i.e. no dose of radiation is considered safe). ◼◼ Linear dose-response relationship with a threshold. This relationship shows that there is a level of dose – the threshold dose (D T ) – below which no response is observed. At the threshold dose, a response is observed and it (the response) increases as the dose is increased. 0004398311.INDD 46 7/8/2019 12:58:24 PM Basic Radiobiology 47 Radiation protection standards and guidelines in diagnostic radiology are based on the linear dose–response relationship without a threshold. The Linear Nonthreshold (LNT) Model Debate Concerns A recent literature review by Tran and Seeram (2017) examining the debate over the LNT model shows the following: However, increasing biological and epidemiological studies have raised doubts on the validity of the model especially at low levels of radiation (<100 mSv), whereby no definitive effects have been demonstrated in humans. A review of literature was conducted using Ovid Medline and Scopus databases to evaluate the controversy surrounding the use of the LNT model and the current perspective of radiation protection organisations on its use. The literature debate consists of arguments against the data obtained from epidemiological studies as well as the consequence effects of the LNT model on the public. In response, alternative dose response models that contradict the accepted LNT model, especially at low doses, have been suggested. These include hormesis, hypersensitivity and threshold models. However, there remains a need for continued research on the effects of low doses radiation on specific organs and tissues to further quantify risk estimates. Further knowledge and understanding of these effects will allow for improved radiation protection for patients. Radiation Effects on DNA and Chromosomes The human cell consists of two major components: the central nucleus surrounded by the cytoplasm. 0004398311.INDD 47 7/8/2019 12:58:24 PM 48 Rad Tech’s Guide to Radiation Protection Target Molecule Compared with the cytoplasm, the nucleus is more radiosensitive because: ◼◼ It contains target molecules that are essential for cell survival. ◼◼ The target molecule is DNA, which is present in all ge- netic and somatic cells in relatively small quantities. ◼◼ Experiments have shown that lower doses of radiation can cause the cell to die when the nucleus (rather than the cytoplasm) is irradiated. Target Theory The target theory states that inactivation of the critical target molecule (DNA) after irradiation will cause the cell to die. Direct and Indirect Effect Radiation interaction with a cell can be by either direct or indirect action. ◼◼ Direct action occurs when the radiation interacts directly with the critical target to cause a series of events (e.g. ionization) leading to changes that are damaging to the cell. ◼◼ Indirect action occurs when radiation interacts with other molecules leading to free radicals, which subsequently interact with the critical target molecule to deactivate it. DNA Damage DNA is made up of two strands forming a double helix composed of sugar base pairs of adenine, guanine, cytosine, and thiamine. Irradiation of DNA can result in the following events: ◼◼ Single-strand breaks or double-strand breaks. ◼◼ Both breaks can be repaired. 0004398311.INDD 48 7/8/2019 12:58:24 PM Basic Radiobiology 49 ◼◼ Single-strand breaks are less damaging than double- strand breaks, which can lead to cell death. ◼◼ Loss or change of base that leads to genetic mutations. ◼◼ Interstrand crosslink resulting in a separation of bases. The previously mentioned lesions produced in DNA by irradiation result in cell death, malignant disease, and genetic effects. Chromosome Damage Chromosomes contain DNA, and damage to DNA leads to chromosome damage. Chromosome damage is also referred to as chromosome aberrations (or breaks). These aberrations can be: ◼◼ Single-hit aberrations, which can occur via the direct or indirect effect. The hit, which is an interaction of radiation with the chromosome, will cause a noticeable derangement of the chromosome. Examples of single-hit aberrations include chromatid breaks and chromosome deletions. ◼◼ Multi-hit aberrations, which result in dicentrics, ring chromosomes, multicentrics, and reciprocal translocations. Experiments have demonstrated that these chromosome aberrations lead to malignancies such as Burkitt’s lymphoma, acute promyelocytic leukemia, and ovarian cancer. Chromosome deletions, specifically, lead to small cell lung cancer, neuroblastoma, retinoblastoma, and Wilms’ tumor. Deterministic Effects (Early Effects of Radiation) When the whole body is exposed to high doses of radiation (greater than 1 Gy), several bioeffects are observed, depending on the dose. These effects are called early effects as they can occur within minutes, hours, days, weeks, and months after the exposure. 0004398311.INDD 49 7/8/2019 12:58:24 PM 50 Rad Tech’s Guide to Radiation Protection ◼◼ Early effects of radiation are considered deterministic effects because the severity of the effect depends on the dose. These effects have a threshold dose and increase with increasing dose. ◼◼ Death is the major effect of whole-body exposure to high doses of radiation. LD50/60 The dose required to kill 50% of the human population in 60 days is termed the lethal dose 50/60 (LD50/60). For humans the LD50/60 is 3.5 Gy (350 rad). Acute Radiation Syndromes Exposure to large doses of radiation to the whole body will result in the following syndromes: ◼◼ Bone marrow syndrome, which occurs after an acute whole-body exposure of 2–10 Gy. The dose affects the stem cells in the bone marrow and other blood-forming organs. ◼◼ Gastrointestinal syndrome, which occurs after an acute whole-body exposure of doses between 10 and 100 Gy. Damage to the crypt cells of the small intestines will cause death, which occurs much faster than that caused by the bone marrow syndrome. ◼◼ Central nervous system (CNS) syndrome, which is also referred to as the cerebrovascular syndrome and requires doses in excess of 100 Gy. Death results because blood vessels in the brain are damaged, leading to edema that causes an increase in skull pressure. Early or deterministic effects can occur in local tissues, such as the skin and gonads, the hemopoietic system, and cell chromosomes. 0004398311.INDD 50 7/8/2019 12:58:24 PM Basic Radiobiology 51 ◼◼ Damages to the skin include skin erythema (reddening) and epilation (loss of hair), which is a result of damage to the basal cells of the epidermis. ◼◼ The principal effect of high doses of radiation on the gonads (ovaries and testes) is atrophy (reduction in size). In women, the oocyte is highly radiosensitive. Radiation exposure of the ovaries can delay or suppress menstruation, as well as cause temporary or permanent sterility. A dose of 2 Gy will cause temporary sterility; 5 Gy will cause permanent sterility. ◼◼ In men, the spermatogonia are most radiosensitive compared with spermatocytes and spermatids. A dose of 100 mGy decreases the spermatozoa count. A dose of 2 Gy produces temporary sterility; 5 Gy will produce permanent sterility. Spermatogonia are also considered to be among the most radiosensitive of body cells (as well as lymphocytes). ◼◼ The blood system or hemopoietic system is made up of the bone marrow, lymphoid tissue, and circulating blood. The main effect of radiation on this system is to reduce the number of blood cells in the peripheral circulation. Among the blood cells, lymphocytes are the most radiosensitive. ◼◼ Chromosomal damage includes single- and multiplechromatid breaks, ring chromosomes, and dicentrics, as well as reciprocal translocations. Stochastic Effects (Late Effects of Radiation) Bioeffects that occur years after exposure to low doses of radiation (less than 0.25 Gy) are considered stochastic effects or late effects. Stochastic effects are those for which the probability of the effect increases as the dose increases and for which there 0004398311.INDD 51 7/8/2019 12:58:24 PM 52 Rad Tech’s Guide to Radiation Protection is no threshold dose. For stochastic effects, there is no riskfree dose. Stochastic effects can occur at the local tissue level and can cause life-span shortening, radiation-induced malignancy, and hereditary effects. Tissue Effects These effects are nonmalignancies that can appear in the skin, eyes, and chromosomes. ◼◼ “The skin develops a weathered, callused, and discolored appearance” (Bushong 2017). ◼◼ Damage has been observed in the chromosomes of circulatory lymphocytes. ◼◼ Cataracts have also been observed in the eye as a late effect of radiation. It is important to note that these effects are not significant in diagnostic radiology, except for skin damage from patients who may have lengthy interventional angiographic procedures. Life-Span Shortening There is no need for radiologists and technologists working in diagnostic radiology to be concerned about life-span effects. Radiation-Induced Cancers Cancer induction is the most significant stochastic effect of radiation. The evidence stems from radium dial painters, uranium miners, atomic bomb survivors, patients exposed to radiation in fluoroscopy, and for ankylosing spondylitis. Additionally, cancer induction is associated with tissues and organs that are highly radiosensitive, such as the lymphoid tissue, bone marrow, the breast and gonads, and the gastrointestinal tract. 0004398311.INDD 52 7/8/2019 12:58:24 PM Basic Radiobiology 53 Radiation-induced cancers include: ◼◼ Leukemia. The incidence of leukemia is dependent on the dose (incidences increase with increased dose). Leukemia may appear 2–3 years after exposure. ◼◼ Lung cancer ◼◼ Breast cancer ◼◼ Thyroid cancer ◼◼ Bone cancer ◼◼ Liver cancer. Hereditary Effects Hereditary effects are stochastic or late effects that occur in the offspring of the irradiated individual. Irradiation of germ cells (spermatozoa or ova) can result in: ◼◼ Chromosomal mutations ◼◼ Gene mutations. Genetic effects of radiation have been studied extensively in animals, the results of which have been extrapolated to humans because the data for humans are limited. As Travis (1997) points out: ◼◼ Most mutations are harmful. ◼◼ Any dose of radiation, no matter how small, can cause genetic changes. ◼◼ There is a linear relationship between dose and the number of mutations, thus information for low doses can be extrapolated from high-dose data. ◼◼ Humans are not more sensitive than mouse and may, in fact, be less sensitive. ◼◼ Mouse data can provide reasonable estimates of the risk of radiation-induced genetic effects in humans. 0004398311.INDD 53 7/8/2019 12:58:24 PM 54 Rad Tech’s Guide to Radiation Protection Radiation Exposure During Pregnancy The human embryo and fetus are highly sensitive to radiation, thus every effort must be made to protect them from unnecessary radiation exposure. A recent review on “Ionizing Radiation Exposure During Pregnancy: Effects on Postnatal Development and Life” by Sreetharan et al. (2017) and published in Radiation Research Journal provides the following summary: There is a major consensus that the atomic bomb survivors’ data shows increased incidence of microcephaly and reductions in IQ of A-bomb survivors, whereas with diagnostic radiography in utero there is no conclusive evidence of increased cancer risk. Due to the relatively limited data (particularly for low-dose exposures) in humans, animal models have emerged as an important tool to study prenatal effects of radiation. These animal models enable researchers to manipulate various experimental parameters and make it possible to analyze a wider variety of end points. In this review, we discuss the major findings from studies using mouse and rat models to examine prenatal ionizing radiation effects in postnatal development of the offspring. In addition, we broadly categorize trends across studies within three major stages of development: pre-implantation, organogenesis and fetal development. Overall, long-term effects of prenatal radiation exposure (including the possible role on the developmental programing of disease) are important factors to consider when assessing radiation risk, since these effects are of relevance even in the low-dose range. 0004398311.INDD 54 7/8/2019 12:58:24 PM 5 Current Standards for Radiation Protection Chapter at a Glance Radiation Protection Organizations Objectives of Radiation Protection Radiation Protection Criteria and Standards Radiation Protection Principles Radiation Protection Actions Recommended Dose Limits Dose Limits for Occupational Exposure Dose Limits for Pregnant Workers Dose Limits for Members of the Public Diagnostic Reference Levels: A Useful Tool for Optimization of Protection I n Chapter 4, the bioeffects of radiation were described. In summary, there are two types of bioeffects: ◼◼ Deterministic effects. These are effects (nonstochastic) for which the severity of the effect increases as the dose increases, and for which there is a threshold dose; below this threshold, no effect occurs. Examples include skin reddening (erythema), epilation (loss of hair), cataracts, Rad Tech’s Guide to Radiation Protection, Second Edition. Euclid Seeram. © 2020 John Wiley & Sons Ltd. Published 2020 by John Wiley & Sons Ltd. 0004398312.INDD 55 7/8/2019 12:59:39 PM 56 Rad Tech’s Guide to Radiation Protection and impairment of fertility. These effects require high doses of radiation, greater than 0.5 Gy (50 rad), and are also referred to as early effects of radiation. ◼◼ Stochastic effects. These are effects for which the probability of occurrence increases with increasing dose and for which there is no threshold dose, meaning that there is no risk‐free dose. With doses of less than 0.5 Gy (50 rad), cancer and genetic damage are concerns. Stochastic effects are also referred to as late effects, among which radiation‐ induced malignant disease (which may appear years after the exposure) is of major concern in diagnostic radiology. The purpose of this chapter is to outline the essential elements of the steps required to prevent deterministic effects and minimize stochastic effects. In other words, this chapter examines the objectives of radiation protection and the two notable triads that serve as a general framework for radiation protection. Radiation Protection Organizations There are several radiation protection organizations responsible for providing guidelines and recommendations on radiation protection. While some of these address radiation risks, others are devoted to radiation protection based on radiation risk data. Important organizations include: ◼◼ The International Commission on Radiologic Protection (ICRP), founded in 1928, issued Publication 26 in 1977. Subsequently in 1990, the commission issued Publication 60, which provides updated recommendations to Publication 26. These two reports provide the basis for regulations and recommendations, not only in the United States and Canada but also in other countries as well. ◼◼ The International Commission on Radiological Units and Measurements (ICRU), established in 1925, deals primarily with radiation quantities and units and measurement 0004398312.INDD 56 7/8/2019 12:59:39 PM Current Standards for Radiation Protection 57 t­ echniques. This commission ensures uniform reporting of data and information on radiation risks and protection. ◼◼ The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) is a committee that issues reports concerning the risks associated with radiation. ◼◼ The Biological Effects of Ionizing Radiation Committee (BEIR) also deals with radiation risks. In 1990, the BEIR issued Report V, which provides updated information on radiation risks. This report states that the risks of radiation are 3–4 times greater than BEIR had previously estimated. It was this finding that led the ICRP to revise its radiation protection guidelines and recommendations in 1990. ◼◼ The National Council on Radiation Protection and Measurements (NCRP) is a United States organization that advises federal and state regulators on matters of radiation protection. ◼◼ The Food and Drug Administration (FDA) in the United States regulates the design and manufacture of X‐ray equipment; the regulations are in Title 21 of the Code of Federal Regulations (CFR). ◼◼ In Canada, the organization responsible for radiation protection in diagnostic radiology is the Radiation Protection Bureau, Health Canada (RPB‐HC). For diagnostic radiology, recommendations are stated in Safety Code 35: Radiation Protection in Radiology‐Large Facilities. Safety Procedures for the Installation, Use, and Control of X‐Ray Equipment in Large Medical Radiological Facilities Objectives of Radiation Protection The objectives of a radiation protection are twofold: ◼◼ To prevent the occurrence of deterministic effects by ensuring that doses are kept below the threshold levels. ◼◼ To minimize the induction of stochastic effects by using a radiation‐protection philosophy that ensures that ­radiologic 0004398312.INDD 57 7/8/2019 12:59:39 PM 58 Rad Tech’s Guide to Radiation Protection examinations are optimized to produce the best image quality with the minimum radiation dose to the patient. A radiation protection philosophy that forms the basis of current radiation protection criteria and standards can achieve these objectives. Radiation Protection Criteria and Standards Radiation protection criteria and standards are based on two triads: ◼◼ Radiation Protection Principles ◼◼ Radiation Protection Actions Radiation Protection Principles The ICRP advocates the following three principles of radiation protection that are currently used by the NCRP and the RPB‐ HC (and other radiation protection organizations around the world) to provide guidelines for the safe use of radiation when imaging patients: ◼◼ Justification. There should be a net benefit associ- ated with exposure to ionizing radiation in light of the known risks of radiation. As pointed out by Wolbarst et al. “Justification provides an essential moral stance for the intelligent use of radiation” (2013). ◼◼ Optimization – ALARA. The principle of optimization ensures that doses are kept As Low As Reasonably Achievable (ALARA), with economic and social factors taken into account. The ICRP also uses the term optimization of radiation protection (ORP). ALARA and ORP are synonymous. ALARA dictates that technologists ­optimize radiologic examinations by practicing the guidelines and recommendations for the safe and prudent use of radiation when imaging patients. Essentially, ALARA 0004398312.INDD 58 7/8/2019 12:59:40 PM Current Standards for Radiation Protection 59 deals with the technical elements of radiation protection, which are intended to ensure optimal image quality using minimal radiation doses. These technical elements are described later in Chapter 9. ◼◼ Dose limitation. This principle addresses the legal limits on the radiation dose received per year or accumulated over a working lifetime for persons who are occupationally exposed and for others as well. There are no limits for patients. The ICRP and national radiation protection organizations, such as the NCRP and RPB‐HC, have established these limits. Additionally, these limits are intended to minimize stochastic effects to acceptable levels and certainly to prevent deterministic effects since they are well below threshold doses. Radiation Protection Actions These actions are the second triad of radiation protection and include time, shielding, and distance. ◼◼ Time. Because the exposure dose is directly proportional to the time of exposure, keeping the time as short as possible will reduce the dose to the individual exposed. ◼◼ Shielding. This aspect involves the use of materials such as concrete or lead between the source of the radiation exposure and the individual exposed. Lead is used in aprons and in the walls of X‐ray rooms. The lead will attenuate the radiation, thus reducing the intensity of the beam. Lead aprons are worn by radiation workers in fluoroscopy, for example, and are also used for gonadal shielding. ◼◼ Distance. Distance is governed by the inverse square law stated as: 1 I d2 where I represents the radiation intensity and d is the distance between the individual exposed and the source of radiation. The law states that the radiation intensity (dose) 0004398312.INDD 59 7/8/2019 12:59:40 PM 60 Rad Tech’s Guide to Radiation Protection is inversely proportional to the square of the distance. Therefore, the dose decreases as the distance increases. If the distance from the radiation source is doubled, then the dose decreases by a factor of four. This law has applications in mobile and operating room radiography and in fluoroscopy. Because the patient is the main source of scatter, the technologists performing mobile radiography and fluoroscopy should stand as far away as possible from the patient when exposing the patient to the radiation beam. For mobile radiography units, the NCRP recommends that the length of the exposure cord be at least 2 m in length. In Canada, the RPB‐HC recommends a length of 3 m. These lengths allow the technologist to stand between 2 and 3 m from the patient during mobile work. Recommended Dose Limits As stated earlier in this chapter, dose limitation is an important element in radiation protection. Dose limitation is based on the fact that radiation can cause biologic harm. That is, radiation can produce stochastic and deterministic effects. The following aspects regarding dose limitation are significant. Dose limits have been set: ◼◼ To minimize the risks of stochastic effects. ◼◼ Using the linear dose‐response model without a threshold. ◼◼ For occupational and nonoccupational exposures. ◼◼ By the ICRP and the NCRP (United States) and the RPB (Health Canada) and are expressed as effective dose (E). Dose Limits for Occupational Exposure Occupational exposures are incurred by virtue of work. For example, technologists and radiologists are occupationally exposed. The dose limits for occupational exposure have been set for uniform whole‐body exposure and individual organs, excluding exposures from medical procedures and from natural background. 0004398312.INDD 60 7/8/2019 12:59:40 PM Current Standards for Radiation Protection 61 Technologists wear dosimeters to measure their occupational exposures. Although the dosimeters do not measure the effective dose (E), “for regulatory compliance it is considered to be E” (Bushong 2017). ◼◼ The ICRP recommended dose limit for occupational exposure is 20 mSv/year averaged over defined periods of five years. ◼◼ The ICRP recommended dose limits for the lens of the eye, skin, and hands and feet, are 150, 500, and 500 mSv/ year, respectively. ◼◼ The dose limits recommended by the NCRP (1993) for occupational exposures are 50 mSv/year; while it is 10 mSv × age of the individual for a cumulative dose limit. ◼◼ The NCRP (1993) recommended annual dose limits for the lens of the eye and for the skin, hands, and feet are 150 and 500 mSv, respectively. ◼◼ The NCRP recommended annual dose limits for students (under the age of 18) in training is 1 mSv; while it is 15 and 50 mSv/year for the lens of the eye and for the skin, hands, and feet, respectively. Students above the age of 18 are subject to the same limits for occupational exposure. ◼◼ The RPB (Health Canada) recommended annual dose limits for occupational exposures are the same as the ICRP limits. Dose Limits for Pregnant Workers With regard to pregnant workers who are in the occupational exposure category, the fetus is “normally considered to be a member of the public” (Huda and Slone 1995). Pregnant workers wear dosimeters under the apron to monitor dose limits to the embryo‐fetus. Bushong notes that: ◼◼ “Once pregnancy is known, the recommended dose limit for the embryo‐fetus takes precedence over the dose limit for the pregnant radiation worker” (2017). 0004398312.INDD 61 7/8/2019 12:59:40 PM 62 Rad Tech’s Guide to Radiation Protection ◼◼ The NCRPs recommended dose limits for the fetus is: ◼◼ 0.5 mSv/month ◼◼ 5.0 mSv for the 9‐month period ◼◼ The ICRPs recommended dose limit for the fetus (9 months) is 1 mSv. Dose Limits for Members of the Public Members of the public are individuals who accompany patients having X‐ray examinations and are waiting in a room in close proximity to an X‐ray room. In general, recommended dose limits for these individuals are less than that of occupationally exposed individuals. ◼◼ The ICRP annual dose limits for members of the public is 1 mSv; while it is 15 and 50 mSv for the lens of the eye and for the skin, hands, and all other organs, respectively ◼◼ For persons who receive continuous or frequent exposures, the NCRP annual limit is 1 mSv; for persons who receive infrequent exposures, the limit is 5 mSv. ◼◼ The NCRP annual dose limits for the lens of the eye and for the skin, hands, and feet (for members of the public) are 15 and 50 mSv, respectively. In this respect, radiology facilities must be shielded (i.e. the walls of X‐ray rooms should be lined with lead to ensure that the dose limits to the public are not exceeded). Diagnostic Reference Levels: A Useful Tool for Optimization of Protection As described previously, dose limits have been established for occupationally exposed individuals such as radiologists and technologists, pregnant workers, and members of the public. What about exposure limits for the patient? In this regard the ICRP, as early as 1990, introduced the notion of Diagnostic 0004398312.INDD 62 7/8/2019 12:59:40 PM Current Standards for Radiation Protection 63 Reference Levels (DRLs), and recommends the use of DRLs for patients. Dose limits and DRLs are not the same thing. The DRL has been defined by several organizations; however, only two, the ICRP and the American College of Radiology (ACR) definitions, are presented here for the sake of brevity. The ICRP states that DRLs “are a form of investigation level, applied to an easily measured quantity, usually the absorbed dose in air, or tissue‐equivalent material at the surface of a simple standard phantom or a representative patient.” The ACR, on the other hand, defines a DRL as “an investigation level to identify unusually high radiation dose or exposure levels for common diagnostic medical X‐ray procedures.” All the definitions reflect that the DRL is a means to optimize the radiation dose to the patient, and it “is to provide a benchmark for comparison, not to define a maximum or minimum exposure limit.” Additionally, the ICRP states that DRLs “apply to medical exposure, not to occupational and public exposure, thus they have no link to dose limits or dose constraints … The values should be selected by professional medical bodies, and renewed at intervals that represent a compromise between the necessary stability and long‐term changes in the observed dose distributions. The selected value will be specific to a country or region.” DRLs are tools radiology departments can use to measure and assess radiation doses to patients for a defined set of procedures. If the doses delivered are consistently greater than established DRLs for that facility’s country or region, then the department should be concerned about its radiation protection procedures, investigate why exposures are beyond the established DRLs, and take corrective action. The details of how DRLs are established is not be described in this text. However, the reader is encouraged to consult any good radiologic physics textbook for a comprehensive explanation. The following points are noteworthy: ◼◼ The general purpose of DRLs is to address patient dose using the principle of ORP. 0004398312.INDD 63 7/8/2019 12:59:40 PM 64 Rad Tech’s Guide to Radiation Protection ◼◼ The following points summarize existing ICRP guide- lines for DRLs: ◼◼ The DRL is an advisory, not a regulatory, measure. It is not related to dose limits established for radiation workers and members of the public. ◼◼ The DRL is intended to identify high levels of radiation doses to patients. ◼◼ The DRL applies to common examinations and specific equipment. ◼◼ Dose quantities and techniques should be easy to measure (e.g. the entrance skin exposure). ◼◼ The DRL selection is established by professional organizations, using a percentile point on the observed distribution for patients, and specific to a country or region. One pragmatic method is to use what has been referred to as a diagnostic reference range. While the upper level of the range is established at the 75th percentile, the lower level is set at the 25th percentile of the computed patient dose. ◼◼ Below the 25th percentile level, image quality may be compromised; above the 75th percentile may indicate excessive dose. ◼◼ For actual DRL values for various imaging examinations, the reader should consult their respective national radiation protection organizations 0004398312.INDD 64 7/8/2019 12:59:40 PM 6 Dose Factors in Digital Radiography Chapter at a Glance Digital Radiography: Essential Considerations Definition Major Differences Between FSR and DR The Standardized Exposure Indicator: Basics Factors Affecting Dose in Digital Radiography Beam Energy and Filtration Exposure Technique Factors Beam Collimation Patient Size Source-to-Image Receptor Distance Radiographic Antiscatter Grids Image Detector Sensitivity or Speed Detective Quantum Efficiency F ilm‐screen radiography (FSR) has been used in radiology ever since the discovery of X‐rays by W.C. Roentgen in 1895. Today FSR is now obsolete and has been replaced by digital Rad Tech’s Guide to Radiation Protection, Second Edition. Euclid Seeram. © 2020 John Wiley & Sons Ltd. Published 2020 by John Wiley & Sons Ltd. 0004398313.INDD 65 7/8/2019 1:00:58 PM 66 Rad Tech’s Guide to Radiation Protection radiographic imaging or, simply, digital radiography. Digital radiography (DR) technologies include not only digital image acquisition modalities but also digital image processing, display, storage, and image communication. Specifically, digital image acquisition modalities include computed radiography, flat‐panel digital radiography, digital mammography, digital tomosynthesis, and digital fluoroscopy for routine gastrointestinal fluoroscopy and vascular imaging. To optimize image quality using exposures as low as reasonably achievable (ALARA), it is mandatory that technologists have a firm understanding of how these factors influence patient dose. The purpose of this chapter is to review the major factors contributing to patient dose in digital radiography. Digital Radiography: Essential Considerations Definition The American Association of Physicists in Medicine (AAPM) has offered a definition of digital radiography as “radiographic imaging technology producing digital projection images such as those using photostimulable storage phosphor (computed radiography, or CR), amorphous selenium, amorphous silicon, charge‐coupled device (CCD), or metal oxide semiconductor– field effect transistor (MOSFET) technology.” These technologies can produce acceptable image quality over a wider range of exposure techniques compared to FSR. Major Differences Between FSR and DR One of the major differences between FSR and DR is the image receptor or image detector. While DR uses a digital detector, the image receptor in FSR is a film cassette (a film sandwiched between two intensifying screens). Digital detectors capture and 0004398313.INDD 66 7/8/2019 1:00:58 PM Dose Factors in Digital Radiography 67 convert X‐ray attenuation data from the patient into electronic signals (analog signals) that are subsequently converted into digital data for processing by a digital computer. The result of processing is a digital image that must be converted into one that can be displayed on a computer monitor for viewing by an observer. The other major difference between FSR and DR is the response of the digital detector to radiation exposure. While film‐screen image receptors have a narrow exposure latitude described by the film characteristic curve (Bushong 2017), DR detectors have a wide exposure latitude. The narrow exposure latitude of FSR means that exposure technique selection must be accurate to achieve an image with acceptable density and contrast, and has been considered a problem for technologists. DR solves this problem, since the wide exposure latitude (linear response to exposure) is about 100 times that of FSR (Don et al. 2012). Additionally, DR images taken with low and high exposures appear visually the same on the viewing monitor (due to the image processing of DR systems). While low exposures produce images with more noise (grainy image), high exposures produce images with less noise but at the expense of increased dose to the patient. The result is that technologists face a difficult task of recognizing underexposed and overexposed images. If overexposed images cannot be determined, the patient receives an unnecessary dose. Overexposures 5–10 times a normal exposure will appear acceptable to the ­technologist. Subsequently, this will lead to what has been popularly referred to as exposure creep or dose creep (Seibert and Morin 2011). Whereas the indicator that the technologist used to determine acceptable image in FSR is the degree of film blackening, in DR the technologist uses an exposure indicator (EI) (also referred to as an exposure index), seen on the image after processing, and which is used to give the technologist some indication of the exposure level to the digital detector. It is important to note that the EI is not patient dose. 0004398313.INDD 67 7/8/2019 1:00:58 PM 68 Rad Tech’s Guide to Radiation Protection With respect to the EI, different DR manufacturers (Fuji, Carestream, Agfa, Konica, Siemens, Philips, and so on) have developed their own proprietary methods to calculate the EI, which has therefore led to different EI names. For example, while Fuji refers to its indicator as a “sensitivity” (S) number, Carestream uses the term “exposure index,” and Agfa uses the term “log of the median of the histogram (lgM).” These differences have created “widespread confusion and frustration.” As a result, the International Electrotechnical Commission (IEC 2008) and the AAPM (2009) have developed a standardized EI. The Standardized Exposure Indicator: Basics The standardized EI uses a linear proportional scale and is related to the detector exposure, that is, if the detector exposure is doubled, the standardized EI doubles. Further details of the standardized EI are described by the IEC (2008), AAPM (2009) and, recently, in a textbook by Seeram (2019). There are four parameters of the IEC standardized EI that are of importance to the technologist, and the radiologist as well. These include the EI, EI T, DI, and VOI, which are defined by the IEC as: ◼◼ EI is a “measure of the detector response to radiation in the relevant image region of an image acquired with a digital X‐ray imaging system.” ◼◼ EI is the “expected value of the exposure index when T exposing the X‐ray image receptor properly.” ◼◼ DI is a “number quantifying the deviation of the actual exposure index from a target exposure index.” ◼◼ VOI is the “central tendency of the original data in the relevant image region. The central tendency is a statistical 0004398313.INDD 68 7/8/2019 1:00:58 PM Dose Factors in Digital Radiography 69 term depicting generally the center of a distribution. It may refer to a variety of measures such as the mean, median, or the mode.” Once the above parameters have been established and images obtained, the DI is seen on every image produced by the technologist for the examination and is used as follows: ◼◼ A DI = 0 means that the intended exposure to the detector is correct (i.e. EI = EIT). ◼◼ A positive DI indicates overexposure, a negative DI indi- cates underexposure. ◼◼ A DI of +1 = an overexposure of 26% more than the desired exposure. ◼◼ A DI of −1 = an underexposure of 20% less than the desired exposure. ◼◼ A DI of +3 = 100% more than the desired exposure. ◼◼ A DI of −3 = 50% less than the desired exposure. ◼◼ The acceptable range of DI numbers is approximately +1 to −1, and the DR system is able to deliver the EI T established by the department. ◼◼ Numbers greater than +1 and less than −1 indicate gross overexposure and underexposure, respectively. Having a firm understanding of the above parameters, especially the DI, technologists can now embrace dose‐image quality optimization with the objective of reducing patient dose without compromising image quality, and hence remove the phenomenon of dose creep. In summary, DR systems now use a standardized EI to provide immediate feedback to the technologist as to whether the correct exposure was used for the examination, through the visual use of the DI value seen on the image. These DI values are affected by a number of technical factors that affect the dose to the patient. These factors are outlined below. 0004398313.INDD 69 7/8/2019 1:00:59 PM 70 Rad Tech’s Guide to Radiation Protection Factors Affecting Dose in Digital Radiography There are numerous factors affecting the dose to the patient in both FSR and digital radiography. The same technical factors used in FSR to create a latent image on the image receptor are also used in DR. The major factors are illustrated in Figure 6.1. The major factors affecting dose to the patient in digital radiography include beam energy and filtration, exposure technique X-ray generator X-ray tube X-ray beam filter X-ray beam collimator Source-to-image receptor distance (SID) X-ray beam Patient (thickness and density) X-ray control console mA kV Time X-ray table top Grid Digital detector Operator (Technologist) Figure 6.1 Major technical factors affect dose to the patient in digital radiography. The radiation passing through the patient is used to create the image, and it is the exposure to the image receptor (digital detector) which ultimately determines the Deviation Index (DI), a parameter of the standardized exposure indicator (EI). 0004398313.INDD 70 7/8/2019 1:00:59 PM Dose Factors in Digital Radiography 71 factors, beam collimation, the size of the X‐ray field, the size of the patient, source‐to‐image receptor distance (SID), grids, image receptor sensitivity or speed, and detective quantum efficiency (DQE). Each of these is now examined briefly. Beam Energy and Filtration The energy of the X‐ray beam is often expressed as the beam quality or the penetrating power of the beam. Beam energy is dependent on at least three factors. ◼◼ Kilovoltage or kV is the voltage applied between the cathode and anode; it affects the energy of the photons striking the patient. High kV results in higher energy photons and a more penetrating beam; low‐kV techniques produce low‐energy photons and a less penetrating beam. The dose to the patient is less in high‐kV techniques compared with low‐kV techniques since more photons are transmitted through the patient. In addition, at low kV, photoelectric absorption predominates and the patient absorbs more photons, thus the dose increases. These were described further in Chapter 2. ◼◼ X‐ray generator. The generator determines the voltage waveform across the X‐ray tube. An important characteristic that describes the way in which the voltage is supplied to the tube is the ripple. When the value of the ripple is low, the efficiency of the generator is greater. Among the three types of generator mentioned earlier – single phase, three phase, and high frequency – the high‐ frequency generator has the lowest ripple, which is less than 3%, compared with 100%, 13%, and 4% for single‐ phase full wave, three‐phase six‐pulse, and three‐phase twelve‐pulse generators, respectively. This factor means that a high‐frequency generator can deliver greater X‐ray quality and quantity compared to single‐ and three‐phase generators. Additionally, higher 0004398313.INDD 71 7/8/2019 1:00:59 PM 72 Rad Tech’s Guide to Radiation Protection kV values (lower mAs) can be used to decrease the dose to the patient. ◼◼ Filtration is intended to protect the patient by removing the low‐energy photons in the X‐ray beam. Filters are added to the X‐ray tube (added filtration) to reduce the quantity of photons and increase the mean energy (quality) of the beam. The beam becomes harder (loss of low‐energy photons) or more penetrating. Filtration reduces patient skin dose. In radiography, aluminum is used as an added filter, the thickness of which depends on the kilovoltage used. The National Council on Radiation Protection and Measurements (NCRP) recommends that for most general radiographic examinations, the total filtration in the beam should be at least a 2.5 aluminum equivalent. Exposure Technique Factors Exposure technique factors include kV, mA, and time of the exposure. These factors are under the direct control of the technologist, who determines the appropriate set of factors depending on the type of examination. These factors control the quality and quantity of radiation reaching the patient; thus they affect the dose in several ways. ◼◼ As noted earlier, kV determines the penetration of the beam and controls the beam quality. High‐kV techniques decrease the dose to the patient, since more radiation penetrates the patient with less absorption. ◼◼ The mA determines the quantity of photons falling on the patient. The radiation dose is directly proportional to the mA. If the mA is doubled, then the dose is increased by a factor of two. ◼◼ The exposure time is directly proportional to the dose. If the time is doubled, then the dose is increased by a factor of two. 0004398313.INDD 72 7/8/2019 1:00:59 PM Dose Factors in Digital Radiography 73 ◼◼ Automatic exposure control (AEC) is designed to reduce exposures to patient, since repeat exposures are minimized. Beam Collimation Collimation is a radiation protection mechanism included in the ALARA philosophy. ◼◼ Collimation reduces the dose to the patient by restricting the size of the radiation beam to the area of clinical interest. This protects the patient from unnecessary exposure. ◼◼ Collimation improves radiographic quality because the amount of scattered radiation reaching the film and the total mass of the patient irradiated are decreased. Patient Size The technologist has no control over the size of the patient. However: ◼◼ As the thickness and the density (mass per unit volume) increase, the dose to the patient increases because more radiation is required to produce the image. ◼◼ Technologists should always use technique charts that provide proper exposure factors for various examinations and patient sizes. Source-to-Image Receptor Distance The SID or the source‐to‐skin distance are major factors that affect patient dose. Most radiology examinations are given at 101 cm (40 in.) because: ◼◼ A long SID produces a less divergent beam at the patient’s surface and reduces patient dose, since the concentration of photons (or surface exposure) decreases (Figure 6.2a). 0004398313.INDD 73 7/8/2019 1:00:59 PM 74 Rad Tech’s Guide to Radiation Protection (a) (b) x x x Figure 6.2 The dose to the patient decreases with a long SID (a), and increases with a short SID (b), since the concentration of photons per unit area increases. (Source: courtesy of Dr. Perry Sprawls, PhD; Distinguished Emeritus Professor, Emory University; Director, Sprawls Educational Foundation, www.sprawls.org; Co-Director, College on Medical Physics, ICTP, Trieste, Italy; Co-Editor, Medical Physics International, http://www.mpijournal.org.) ◼◼ At a short SID, the dose to the patient increases, the radi- ation beam is more divergent at the patient’s surface, and the concentration of photons per unit area (surface exposure) increases (Figure 6.2b). Radiographic Antiscatter Grids A grid improves radiographic contrast by absorbing scattered radiation from the patient, thus preventing it from reaching the image receptor. Whenever a grid is used in an examination, the dose to the patient increases compared with nongrid examinations. Among the performance characteristics of a grid, the grid ratio affects the dose to the patient. ◼◼ As the grid ratio increases, the dose to the patient increases. ◼◼ High‐ratio grids should be used with high‐kV techniques. 0004398313.INDD 74 7/8/2019 1:01:00 PM Dose Factors in Digital Radiography 75 ◼◼ When high‐ratio grids are used with high‐kV techniques, the dose to the patient decreases, because more radiation is transmitted through the patient and not absorbed by the patient. The entrance doses for a 12:1 grid at 70, 90, and 110 kV are 2.1, 2.0, and 1.5 mGy, respectively (using a 400 speed image detector) (Bushong 2017). ◼◼ Moving grids that have the same characteristics as stationary grids require approximately 15% more exposure. Therefore, moving grids increase the dose to the patient (Bushong 2017). Image Detector Sensitivity or Speed The image detector is the image receptor used to produce images of the patient. The speed refers to the amount of radiation used to produce the image (i.e. sensitivity refers to the overall efficiency of the image receptor). Image receptor speeds are expressed as numbers and may range from 200 to 400 to 800 and may extend beyond 800. ◼◼ The dose to the patient (including gonadal dose) is inversely proportional to the sensitivity of the image receptor. ◼◼ This factor means that increasing the speed by a factor of two (i.e. going from a 200‐speed system to a 400‐speed system) will reduce the dose by one half. ◼◼ Depending on the phosphors being used and their conversion efficiencies, rare‐earth image receptors can reduce exposures by 50% or more, compared with older calcium tungstate image receptors. ◼◼ Image receptors with carbon fiber fronts will reduce the dose by 6–12% compared with cassettes having aluminum fronts. Detective Quantum Efficiency A characteristic related to the image receptor sensitivity or speed is the DQE, which is intended to measure the efficiency with which the detector converts an input exposure into a 0004398313.INDD 75 7/8/2019 1:01:00 PM 76 Rad Tech’s Guide to Radiation Protection ­ iagnostic output image. The performance of a perfect detector d is 1 or 100% which reflects that there is no loss of information in the conversion of the input exposure into a useful image. It is not within the scope of this chapter to describe the details of the DQE The interested reader may, however, refer to a textbook by Seeram (2019) for a further description of the DQE at the technologist level. 0004398313.INDD 76 7/8/2019 1:01:00 PM 7 Dose Factors in Fluoroscopy Chapter at a Glance Major Components of Fluoroscopic Imaging Systems Image Intensifier Fluoroscopy: Major System Components Digital Fluoroscopy: Major System Components Factors Affecting Dose in Fluoroscopy Beam Energy Tube Current Beam-on Time Automatic Exposure-Rate Control Collimation Source-to-Skin Distance Patient Size Antiscatter Grids Image Magnification Last Image Hold Pulsed Fluoroscopy Scattered Radiation in Fluoroscopy Rad Tech’s Guide to Radiation Protection, Second Edition. Euclid Seeram. © 2020 John Wiley & Sons Ltd. Published 2020 by John Wiley & Sons Ltd. 0004398314.INDD 77 7/8/2019 1:02:22 PM 78 Rad Tech’s Guide to Radiation Protection F luoroscopy is an X‐ray imaging technique that allows the radiologist to observe real‐time images on a televi‑ sion screen to study the dynamics or motion of organ sys‑ tems, particularly circulation and hollow internal anatomy. Fluoroscopy can provide diagnosis and guidance in interven‑ tional X‐ray studies. There are several reasons why the dose in fluoroscopy is important to radiology workers: ◼◼ Several recent reports indicate that patient doses in fluo‑ roscopy are extremely high compared with most radiology procedures, and that some patients have experienced radiation‐induced injuries such as skin burns (Bushberg et al. 2012). ◼◼ Occupational exposures are highest in fluoroscopy (Bushong 2017). ◼◼ The technologist is an integral part of the fluoroscopic examination and is present in the room to deal with the patient and to assist the radiologist during the fluoroscopic portion of the examination. The purpose of this chapter is to provide a description of the major components of a fluoroscopic system and to highlight the significant factors affecting patient dose in fluoroscopy. Major Components of Fluoroscopic Imaging Systems Two major f luoroscopic imaging systems are shown in Figure 7.1. The older fluoroscopic imaging system is shown in Figure 7.1a, while a newer digital fluoroscopic imaging system is illustrated in Figure 7.1b. The former systems, however, are rapidly being replaced by digital fluoroscopic imaging systems. Therefore, there are two types of fluoroscopy system used in medical imaging departments: 0004398314.INDD 78 7/8/2019 1:02:22 PM Dose Factors in Fluoroscopy (a) 79 (b) X-ray tube Patient Grid X-ray image intensifier tube Flat-panel digital detector Digital data Output analog signal Image Computer Circular image on TV monitor Rectangular image on TV monitor Figure 7.1 Two major fluoroscopic imaging systems in use today. An older fluoroscopic imaging system is shown in (a), a newer digital fluoroscopic imaging system is illustrated in (b). 1. Image Intensifier‐Based Fluoroscopy Systems (Image Intensifier Fluoroscopy) 2. Flat‐Panel Digital Detector‐Based Fluoroscopy Systems (Digital Fluoroscopy) Image Intensifier Fluoroscopy: Major System Components The major components as shown in Figure 7.1a are: ◼◼ X‐ray tube and generator. The X‐ray generator provides the power to the X‐ray tube for the production of X‐rays. 0004398314.INDD 79 7/8/2019 1:02:23 PM 80 Rad Tech’s Guide to Radiation Protection In fluoroscopy, the kV is high and the mA is low, since the X‐ray tube is energized continuously. Naturally, other factors affect the choice of exposure aspects in fluoros‑ copy. For undertable fluoroscopy, the X‐ray tube is located below the table; for overhead or overtable fluoroscopy, the X‐ray tube is positioned over the table and is used for both fluoroscopy and radiography (images taken after the fluoroscopic portion of the examination). These images are generally referred to as “overhead images.” ◼◼ Image intensifier tube. The purpose of the image inten‑ sifier tube in the fluoroscopic imaging chain is to increase the brightness of the fluoroscopic image using extremely low mA values applied to the X‐ray tube. Radiation trans‑ mitted through the patient falls on an input screen (cesium iodide phosphor) that converts X‐ray photons to light. The light photons, in turn, are converted to electrons by a pho‑ tocathode in the tube. These electrons are subsequently accelerated across the tube to strike an output screen that is approximately one‐tenth the diameter of the input screen (zinc cadmium sulfide phosphor). The image at the output screen is increased in brightness from the acceleration of the electrons and the minification at the output screen. This image cannot be observed directly, thus it must be sent to a monitor for display and viewing. To aid in visualization and diagnosis, image intensifiers can also magnify the image viewed on the television monitor. Magnification plays a significant role in the dose to the patient. ◼◼ Image distributor. This component of the imaging chain distributes the light from the output screen of the image intensifier tube. Approximately 90% of the light reaches the film recording camera (cine or spot‐film camera); 10% is directed to the television camera. ◼◼ Television camera or charge‐coupled device (CCD). The image at the output screen is picked up using a 0004398314.INDD 80 7/8/2019 1:02:23 PM Dose Factors in Fluoroscopy 81 t­ elevision camera tube or a solid‐state device called a CCD and is transmitted via a coaxial cable to the televi‑ sion monitor. ◼◼ Television monitor. The television monitor receives a video signal from the television camera tube or CCD and creates the image on the output screen of the image inten‑ sifier tube. The television monitor is the picture tube or cathode ray tube that displays the image for viewing by the radiologist. ◼◼ Spot‐film recording devices. These devices include cas‑ sette‐loaded spot films and films recorded by photo‐spot cameras, and are now obsolete. Digital Fluoroscopy: Major System Components The major components, as shown in Figure 7.1b, are: ◼◼ X‐ray tube and generator. The X‐ray generator provides the power to the X‐ray tube for the production of X‐rays, as reviewed above. ◼◼ Scattered radiation grid. This device is positioned between the patient and the detector for the purpose of reducing the scattered radiation from the patient and preventing these scattered rays from reaching the detector. ◼◼ Flat‐panel digital detector. The digital detector for fluoroscopy is a dynamic detector. This means that the detector must be capable of producing moving images that can be displayed in real time. There are two types of digital fluoroscopy detector: (i) the cesium iodide, amor‑ phous‐silicon thin film transistor (TFT) (CsI a‐Si TFT) indirect digital detector, and (ii) the amorphous‑selenium TFT direct detector (a‐Se TFT). These detectors will not be described further in this text; however, the reader is encouraged to refer to Seeram (2019), Bushong (2017), 0004398314.INDD 81 7/8/2019 1:02:23 PM 82 Rad Tech’s Guide to Radiation Protection and Bushberg et al. (2012) for detailed functional expla‑ nations of how these detectors work. ◼◼ Computer to process all data from the patient and subse‑ quently display images on a television monitor. ◼◼ Image display monitor. Current displays are flat‐screen liquid crystal display monitors. Factors Affecting Dose in Fluoroscopy The major factors affecting the dose to the patient in fluoros‑ copy include: ◼◼ Beam energy or filtration ◼◼ Tube current ◼◼ Beam‐on time ◼◼ Automatic dose‐rate control ◼◼ Collimation ◼◼ Source‐to‐skin distance (SSD) ◼◼ Patient‐to‐image intensifier distance ◼◼ Patient size ◼◼ Antiscatter grids ◼◼ Image magnification ◼◼ Last image hold ◼◼ Image recording method ◼◼ Pulsed fluoroscopy. Beam Energy Beam energy refers to the penetrating power of the X‐ray photons in the X‐ray beam emanating from the X‐ray tube. Kilovoltage (kV), filtration, and the type of X‐ray generator used to provide power to the X‐ray tube affect the beam energy. ◼◼ When kV is high, penetration of the X‐ray beam is greater and more photons are transmitted through the patient (less absorption), lowering the dose to the patient. 0004398314.INDD 82 7/8/2019 1:02:23 PM Dose Factors in Fluoroscopy 83 ◼◼ Higher kV beams, however, result in a loss of image contrast. ◼◼ Fluoroscopic imaging systems are provided with filters for the purpose of protecting the patient. ◼◼ Filters reduce the dose to the patient by absorbing the low‐energy photons from the X‐ray beam that would oth‑ erwise be absorbed by the patient’s skin surface and fail to reach the film. ◼◼ The removal of these photons increases the mean energy of the beam, thus increasing the penetrating power of the beam. The result is a smaller dose to the patient, since more photons are transmitted to the image receptor. ◼◼ High‐frequency generators produce more photons with higher energies than single‐phase and three‐phase X‐ray generators. Higher beam energies allow patients to receive a smaller dose. Tube Current The tube current is the mA. In fluoroscopy, the mA is low because the fluoroscopic exposure time can range from min‑ utes to hours. Additionally, since high kV values are generally used, the mA is reduced substantially. ◼◼ Fluoroscopic mA used in image intensifier fluoroscopy systems ranges from 1 to 3 mA. ◼◼ For digital fluoroscopy systems the mA is measured in hundreds of mA instead of less than 5 mA (Bushong 2017). In order to deal with dose increases from the use of hundreds of mA, a technique known as pulse‐progressive fluoroscopy is used. ◼◼ Lower kV, however, will increase the mAs, thus increasing the dose to the patient. Beam-on Time The beam‐on time refers to the length of time that the X‐ray tube is energized to produce X‐rays for real‐time image display. 0004398314.INDD 83 7/8/2019 1:02:23 PM 84 Rad Tech’s Guide to Radiation Protection ◼◼ Continuous exposures increase beam‐on time, thus increasing patient dose. The dose is directly proportional to the exposure time. If the beam‐on time is doubled, the dose is increased by a factor of two. ◼◼ Short, intermittent exposures reduce patient dose, which is referred to as intermittent fluoroscopy (short bursts of beam‐on time). Automatic Exposure-Rate Control Automatic exposure‐rate control (AERC) is also referred to as automatic brightness control (ABC) and is a technique that maintains the image brightness on the television monitor when the anatomic part thickness changes. ◼◼ The AERC plays an important role in maintaining constant signal‐to‐noise ratio (SNR) in the image, by altering the mA and kV automatically as the thickness of the patient varies in the beam path, thus resulting in dose control. ◼◼ When a nonuniform object such as a wedge (or from the patient’s neck to abdomen) is being examined by fluoros‑ copy, the image brightness will change as the X‐ray tube moves from the thick part to the thin part and from bright to extremely bright, respectively. ◼◼ The X‐ray beam intensity (therefore the dose) increases as the tube moves from the thick part to the thin part. Without AERC the dose to the thin part would increase. ◼◼ With AERC the exposure technique factors change automat‑ ically to maintain the same brightness of the image as the tube moves from the thicker to the thinner anatomic part. Collimation As stated in Chapter 6, collimation is intended to protect the patient from unnecessary radiation by limiting or restricting the beam to the clinical area of interest. 0004398314.INDD 84 7/8/2019 1:02:23 PM Dose Factors in Fluoroscopy 85 ◼◼ Fluoroscopy collimators ensure that the clinical area of interest receives minimal radiation by shaping the beam to cover only the desired region under study. ◼◼ The smallest possible field size is recommended to ensure low doses to the patient. ◼◼ Collimation also ensures good quality images by reducing the amount of scattered radiation reaching the image receptor (image intensifier input screen). Source-to-Skin Distance The SSD in fluoroscopy can affect the dose to the patient, since the concentration of photons per unit area is greatest for shorter SSD. The SSD can be described as short (X‐ray tube close to the patient) or long (X‐ray tube farther away from the patient). ◼◼ The patient dose is reduced when the image intensifier tube is close to the patient and the X‐ray tube is farther away from the patient. This arrangement represents the best geometry of three geometries commonly used in practice. ◼◼ A poor beam geometry is a situation where the X‐ray tube is too close to the patient, thus resulting in a greater dose compared to a situation where the detector (digital detector or image intensifier) is close to the patient using the same SSD. ◼◼ Furthermore, if the image intensifier tube is too far away from the patient, the dose increases compared to a situation where the detector is close to the patient dur‑ ing imaging. Patient Size This factor is not under the control of the fluoroscopist. ◼◼ Thicker patients will require more radiation to produce optimal image brightness, detail, and contrast compared with thinner patients. 0004398314.INDD 85 7/8/2019 1:02:23 PM 86 Rad Tech’s Guide to Radiation Protection ◼◼ The kV and mA must be increased to image thicker patients, resulting in a higher patient dose. Antiscatter Grids A grid is used in fluoroscopy to improve image contrast by pre‑ venting scattered radiation from reaching the input screen of the image intensifier tube. ◼◼ Grids introduced into the radiation beam during the examination will increase the patient dose by a factor of two or more. Therefore, not using a grid can reduce the dose by a factor of two or more. ◼◼ Increasing the distance between the patient and the image intensifier tube by a reasonable quantity, can reduce the scattered radiation by using the air‐gap technique (radi‑ ation scattered at extremely oblique angles will fall out of the gap and will not reach the image intensifier tube). Image Magnification The image in fluoroscopy can be magnified to facilitate diag‑ nosis. Image magnification can be achieved by geometric and electronic means. The former involves increasing the distance between the patient and the image intensifier tube; the latter involves collimating the beam automatically to fall only on a small central portion of the image intensifier input screen. ◼◼ Geometric magnification increases the patient dose in fluoroscopy, as described earlier. ◼◼ Electronic magnification results in an increase in mA to maintain the brightness level on the television monitor, thus increasing the dose to the patient. ◼◼ The dose increase is approximately equal to the ratio of the sizes of the input screen used for the normal mode and for the magnification mode. 0004398314.INDD 86 7/8/2019 1:02:23 PM Dose Factors in Fluoroscopy 87 ◼◼ A dual‐mode (25/17 cm) image intensifier tube will deliver a 2.2 times (252 ÷ 172) greater dose to the patient when operating in the 17 cm mode or magnification mode (Bushong 2017). Last Image Hold Last image hold is a technique used to describe images that can be stored digitally and displayed on the television continuously without the need for continuous fluoroscopy. Usually the last image is displayed on the monitor electronically for a period of time. Last‐image‐hold techniques can reduce patient dose by 50–80% (Bushberg et al. 2012). Pulsed Fluoroscopy Pulsed fluoroscopy is a technique during which the X‐ray beam is pulsed (produced in short bursts) compared with being pro‑ duced continuously. ◼◼ Pulsed fluoroscopy reduces the dose to the patient by as much as 90% (depending on the number of pulses per second) compared with nonpulsed units. ◼◼ Pulse fluoroscopy can reduce the scattered radiation expo‑ sures to personnel. ◼◼ Pulsed fluoroscopy can also be used as an effective means to reduce doses to children undergoing fluoroscopic examination. Scattered Radiation in Fluoroscopy Because occupational exposures are highest in fluoroscopy, it is essential to consider the nature of this exposure. Technologists and radiologists are exposed to scattered radia‑ tion in fluoroscopy, as they are in the room assisting the patient during the examination. 0004398314.INDD 87 7/8/2019 1:02:23 PM 88 Rad Tech’s Guide to Radiation Protection ◼◼ The main source of scattered radiation is the patient, although the equipment can produce scattered radia‑ tion as well. ◼◼ When higher levels of primary beam exposures (also referred to as the high dose‐rate mode or high‐level control fluoroscopy) are used, more scattered radiation is produced. ◼◼ A higher level of scattered radiation reaches the fluorosco‑ pist when the primary beam is off the patient’s mid line, because there is less attenuation of the primary beam by the patient, as it is closer to the operator. ◼◼ The distribution of scattered radiation when no protective curtain is hanging on the spot‐film device is higher com‑ pared to when a protective curtain is used (Bushong 2017). ◼◼ To reduce occupational exposures in fluoroscopy, always wear lead aprons and try to stand back from the table during beam‐on times. ◼◼ The radiation monitor must be worn at the level of the collar, outside the protective apron (in the United States) and under the apron at the waist level (in Canada) to record the dose from scattered radiation. 0004398314.INDD 88 7/8/2019 1:02:23 PM 8 Factors Affecting Dose in Computed Tomography Chapter at a Glance Computed Tomography: A Definition Nobel Prize for CT Pioneers CT Principles: The Basics Physics and Technology Multislice CT Technology: The Pitch Dose Distribution in CT CT Dose Metrics CT Dose Index Dose Length Product Size-Specific Dose Estimate Effective Dose Factors Affecting the Dose in CT Exposure Technique Factors Pitch Effective mAs Rad Tech’s Guide to Radiation Protection, Second Edition. Euclid Seeram. © 2020 John Wiley & Sons Ltd. Published 2020 by John Wiley & Sons Ltd. 0004398315.INDD 89 7/8/2019 1:04:17 PM 90 Rad Tech’s Guide to Radiation Protection Collimation and Slices Overranging and Overbeaming ATCM and Image Quality Index Automatic Voltage Selection Iterative Reconstruction Algorithms Dose Optimization in CT Computed Tomography: A Definition Computed tomography (CT) is a sectional imaging technique that produces direct cross‐sectional digital images referred to as transverse axial images (transaxial images). These images have been defined as planar sections that are perpendicular to the long axis of the patient. The word “computed” implies that a computer is used to process and reconstruct X‐ray transmission data collected from the patient. Ever since its invention in the early 1970s, there have been several notable developments in CT scanning. These have resulted in improved scanning technologies, and improved image quality, both of which play a vital role in the care and management of the patient during CT examinations. The CT scanner has evolved from single slice CT scanners to ­multislice CT scanners (MSCT). State‐of‐the‐art CT scanners are now MSCT scanners capable of a wide range of applications. These applications range from scanners dedicated to imaging the beating heart with excellent image quality to scanners that are used not only in nuclear medicine imaging but also in radiation treatment planning. These technological advances have contributed to the increasing use of CT to image not only adults but children as well. One important consequence of such increasing use is that CT delivered the highest collective dose in the United States compared to other medical imaging modality (Fleischmann and Boas 2011). 0004398315.INDD 90 7/8/2019 1:04:17 PM Factors Affecting Dose in Computed Tomography 91 Nobel Prize for CT Pioneers Two individuals shared the Nobel Prize in Medicine and Physiology in 1979 for their development of the CT scanner. These were Godfrey Newbold Hounsfield in the United Kingdom (UK), who invented the first clinically useful scanner, and Allan Cormack, a physicist at Tufts University in Massachusetts. For a detailed account of each of their contributions, the reader should refer to a CT textbook by Seeram (2016). CT Principles: The Basics CT is a multidisciplinary technology and has its roots in physics, mathematics, engineering, and computer science. It is not within the scope of this chapter to describe the elements of each of these subjects, however it is essential for the user to have a broad understanding of the fundamental concepts related to the physics and technology. These concepts are important to understanding the factors affecting the dose to the patient having a CT examination. Physics and Technology The CT process comprises at least three major system components that are used to produce the CT image. These system components include: (i) the data acquisition system, (ii) the computer system, and (iii) the image display, storage and communication systems. Data acquisition means that radiation attenuation data are collected from the patient during the scanning. In this respect, an X‐ray tube coupled to special electronic detectors rotate around the patient to collect and measure attenuation readings as the X‐ray beam passes through the patient. The attenuation is according to Beer–Lambert’s law I 0004398315.INDD 91 I oe x 7/8/2019 1:04:17 PM 92 Rad Tech’s Guide to Radiation Protection where I is the transmitted X‐ray beam intensity, Io is the original X‐ray beam intensity, e represents Euler’s constant, μ is the linear attenuation coefficient, and Δx is the finite thickness of the section. In CT, the system calculates all linear attenuation coefficients for all structures seen on the image. Special detectors and detector electronics are used to calculate the attenuation data and convert them into integers (0, a positive number, or a negative number), referred to as CT numbers, using an image reconstruction algorithm to build up the image in numerical format. The CT numbers (numerical image format) are converted into a gray scale image for display on a monitor for the observer to interpret. The CT numbers are calculated using the following relationship: CT number tissue water water K where K represents a scaling factor. In general, K is equal to 1000. When Hounsfield invented the scanner, K was equal to 500. The main message in the above paragraphs is that the attenuation depends on several physical factors (physics) that all play a role in the dose to the patient. These are described briefly later in the chapter. The technology aspects of CT are complex but they enable the attenuation values collected around the patient for 360° to be used to build up an image of the internal anatomy of the patient, and for such an image to be displayed for interpretation by radiologists. The technology addressing the collection of these values includes the X‐ray tube, which is coupled to special electronic detectors and detector electronics. Another major technology component in CT is the computer system, which captures the raw data from the detectors and uses sophisticated image reconstruction algorithms to create the image from the raw data. Display, storage, and communication of processed images are accomplished using digital technologies. A display monitor also allows the interpreter to manipulate the image using special 0004398315.INDD 92 7/8/2019 1:04:17 PM Factors Affecting Dose in Computed Tomography 93 image processing operations. Images are subsequently stored on magnetic or optical data carriers and can be communicated by electronic means to other locations using Picture Archiving and Communication Systems (PACS). Multislice CT Technology: The Pitch As noted in the introduction, all present day CT scanners are MSCT scanners. One characteristic feature of MSCT scanners is the two‐dimensional detector array, compared to the one‐dimensional detector array of single slice CT scanners (SSCT). The principles of MSCT are not within the scope of this chapter and the reader is encouraged to refer to major physics textbooks, such as the one by Bushberg et al. (2012), or to consult CT‐specific textbooks, such as one by Seeram (2016) or a review article (Seeram 2018). This means that there will be additional specific technical factors that affect the dose in CT. These factors are described below. One such notable factor is the pitch (P), which is defined by the International Electrotechnical Commission (IEC) as the distance the table travels per rotation (D) divided by the total collimation (W). This can be expressed algebraically as: P D/W Furthermore, the total collimation (W) is equal to the number of slices (M) times the collimated slice thickness (S). The pitch can now be expressed algebraically as: P D/ M S Dose Distribution in CT The increasing use of CT has led to widespread concerns about high patient radiation doses from CT examinations relative to other radiography examinations. The distribution of the dose to 0004398315.INDD 93 7/8/2019 1:04:17 PM 94 Rad Tech’s Guide to Radiation Protection the patient in CT is significantly different than the distribution of the dose in radiography. Whereas radiography uses a stationary X‐ray beam and a stationary detector, CT uses a rotating X‐ray beam and detectors around the patient for 360°. Because of this, the dose distribution in radiography is considered nonuniform and results in a distribution of the dose that is 100% at the surface of the patient and about 3% at the detector. In CT, the dose distribution is more uniform at the surface of the patient and decreases toward the center. Additionally, in CT there is a concern about the relative contribution of scatter to the absorbed dose. These differences require additional CT‐specific dose metrics. CT Dose Metrics There are four essential CT‐specific dose metrics: the Computed Tomography Dose Index (CTDI), the Dose Length Product (DLP), the Size‐Specific Dose Estimate (SSDE), and the Effective Dose (ED). The basics of these four metrics is described briefly here. For detailed descriptions, the reader should refer to the American Association of Physicists in Medicine (AAPM) report by Task Group 204 (2011). CT Dose Index The CTDI is a standardized measure of the radiation output from a CT scanner and is used to compare the radiation output different CT scanners (Bushberg et al. 2012). Specifically, the dose in the z‐axis of the patient (line drawn from head to toe) in the CT scanner is referred to as the CTDIvol for MSCT; it is expressed in milligray (mGy). The following algebraic expression is used to calculate the CTDIvol. CTDI vol CTDI weighted / PITCH where the weighted CTDI (CTDIw) is used to account for the average dose in the x–y axis of the patient instead of the z‐axis. 0004398315.INDD 94 7/8/2019 1:04:18 PM Factors Affecting Dose in Computed Tomography 95 For a pitch of 1, the CTDIvol is equal to the CTDTw. The CTDIvol is not used to estimate the dose to the patient. Dose Length Product The CTDIvol is used to provide a measurement of the dose per slice of tissue and is the same whether the user scans a 10 mm or a 100 mm scan length. Thus another metric is required. This is the DLP, which is a much more accurate reflection of the dose for a defined length of tissue. The DLP is directly proportional to the scan length (L) in centimeters (cm) along the z‐axis and is expressed in mGy‐cm. The DLP can be calculated as follows: DLP CTDI vol L The CTDIvol is the same regardless of the size of the patient, that is, the CTDIvol is the same for a large patient as it is for a small patient (keeping all scan parameters the same). Therefore, another metric is used to take into consideration the size of the patient. Size-Specific Dose Estimate The SSDE is given by the formula: SSDE16 CTDI vol for a16 cm CTDI phantom Conversion factor f for the16 cm CTDI phantom or SSSD32 CTDI vol for a 32 cm CTDI phantom Conversion factor f for the32 cm CTDI phantom The conversion factors (ƒ 16 and ƒ 32) are provided in the AAPM report (2011) for different patient sizes. The reader is encouraged to consult this report for further details. These details are not within the scope of this book. 0004398315.INDD 95 7/8/2019 1:04:18 PM 96 Rad Tech’s Guide to Radiation Protection Effective Dose In order to consider the risk of a CT examination, the use of the ED is the metric used. ED is used in radiation protection to relate exposure to risk, and it takes into account that different tissues have different radiosensitivities. Wolbarst et al. (2013) noted that the DLP can provide only a rough estimate of ED In practice, however, the DLP is approximately proportional to the ED and can be calculated using the following relationship: ED k DLP where k is a constant. While the k value (mSv/mGy‐cm) for a CT scan of the head is 0.0021, it is 0.015 for a CT scan of the pelvis (McNitt‐Gray 2002). The ED can be used to compare the CT dose with the dose received from natural background radiation. The annual ED from natural background radiation is reported to be 3 mSv, while it is 1.5 mSv for CT and 3 mSv for medical imaging (Bushong 2017). Factors Affecting the Dose in CT Several factors affect the dose in CT. Major factors include exposure technique factors (mAs and kV), pitch, effective mAs, collimation and slices, overbeaming and overranging, automatic tube current modulation (ATCM), automatic voltage selection (AVS), and iterative reconstruction (IR) algorithms (McCollough 2019). Exposure Technique Factors The dose is directly proportional to the mAs and directly proportional to the square of the kV change. CTDI vol mAs 0004398315.INDD 96 7/8/2019 1:04:18 PM Factors Affecting Dose in Computed Tomography CTDI vol kVnew / kVold 97 2 Pitch The pitch is defined above by the IEC. The CT dose is related to the pitch (when all parameters such as for example, mA and rotation time) are held constant, as follows: CTDI vol 1/ Pitch Effective mAs The effective mAs is a ratio of the true mAs to the pitch. CTDI vol mAseffective Collimation and Slices The X‐ray beam width is defined by the collimation and for MSCT, the slice or section thickness (width) is defined by the number of detector elements grouped or binned together in each detector channel (Bushberg et al. 2012; Seeram 2016). As the collimation width increases and the slice thickness decreases, the dose decreases and increases respectively. Decreasing the section thickness means that the exposure technique be increased to maintain the same signal‐to‐noise ratio (SNR). Overranging and Overbeaming As described by Goo (2012), while overranging refers to the use of additional rotations before and after the planned length of tissue so the first and last images can be reconstructed, overbeaming is the excess dose beyond the edge of the detector rows per rotation of a multisection. Both of these parameters increase the patient dose. To address this problem, adaptive collimation is 0004398315.INDD 97 7/8/2019 1:04:19 PM 98 Rad Tech’s Guide to Radiation Protection used in MSCT scanners to reduce patient dose at the beginning and end of scanning, and dose reduction of about 40% is possible (Christner et al. 2010). ATCM and Image Quality Index The overall goal of ATCM, categorized as Automatic Exposure Control (AEC) is to adjust the mA in either the z‐axis (longitudinal), the x‐y axis (angular), or both, in an effort to reduce patient dose. An important feature of AEC systems is a preselected image quality index, also referred to as a reference or target image quality index. This index is an operator‐selectable parameter. Different CT vendors have different names for this index. For example, General Electric (GE) Healthcare refers to this index as the Noise Index (NI). Coakley et al. (2011), for example, showed that ATCM can reduce the dose by 20–40% in adults. Furthermore, as the NI increases, the patient dose decreases but at the expense of a noise, since the NI is inversely proportional to the square root of the dose. Automatic Voltage Selection The purpose of AVS is to optimize kV for the diagnostic task and patient size in an effort to obtain lower CTDIvol while maintaining acceptable image quality. The kV is not modulated as is the case with ATCM technique. It is important to note, however, that as the kV is changed the mA changes as well to maintain a constant Contrast‐to‐Noise Ratio (CNR). A study conducted by Oda et al. (2011) showed that low tube voltage in cardiac CT imaging reduced the dose by about 55% in slim patients while maintaining image quality. Iterative Reconstruction Algorithms As mentioned earlier, CT uses an image reconstruction algorithm to create the image knowing the values of all attenuation data collected from the patient. In the past, the filtered 0004398315.INDD 98 7/8/2019 1:04:19 PM Factors Affecting Dose in Computed Tomography 99 back projection (FBP) algorithm was commonly used. However, the FBP algorithm, produces image noise and streak artifacts, and therefore other algorithms are now being used to solve these problems. These algorithms are referred to as IR algorithms and all major CT manufacturers employ IR algorithms on their scanners (Beister et al. 2012; Kaza et al. 2014). The major goals of IR algorithms are to reduce image noise and minimize the higher dose inherent in the FBP algorithm. IR algorithms use the FBP algorithm image data (measured projrction data) and create simulated data. The simulated data are then compared with the initial measured projection data to determine the differences in image noise. Once the difference is determined, it is applied to the simulated data to correct for inconsistencies. A systematic review of the IR literature entitled “Does IR improve image quality and reduce dose in CT” (Qiu and Seeram 2016) concluded that there is general consensus that IR algorithms can faithfully reduce radiation dose and improve image quality in CT in comparison with the FBP algorithm. A number of studies for example have shown that IR can reduce the dose from 30 to 50% (Maldjian and Goldman 2013; Kaza et al. 2014). Dose Optimization in CT The International Commission on Radiological Protection (ICRP) optimization framework refers to optimization as keeping the dose as low as reasonably achievable (ALARA) while not compromising the diagnostic quality of the image. In an early paper, Goo (2012) provides a checklist for dose optimization in CT in which several “checkup items” and recommendations are provided in clear and simple terms, These items include body size‐adapted, CT protocols, tube current modulation, optimal tube voltage at equivalent radiation dose, longitudinal scan range, repeated scans, scan modes, and noise‐ reducing image reconstruction algorithms. 0004398315.INDD 99 7/8/2019 1:04:19 PM 100 Rad Tech’s Guide to Radiation Protection An important consideration in dose optimization in CT means that image quality must not be compromised at lower doses. Furthermore, the diagnostic performance of radiologists must also be taken into consideration as the dose is reduced (McCollough 2019). In this regard, there are several resources for the user to consult. Two such resources are the AAPM Alliance for Quality CT, and the Image Gently® and Image Wisely® campaigns. 0004398315.INDD 100 7/8/2019 1:04:19 PM 9 Dose Management Regulations and Optimization Chapter at a Glance Federal Regulations for Dose Management Safety Reports for Guidelines and Responsibilities Definition of Terms in Safety Reports Equipment Specifications for Radiography X-Ray Control Panel Leakage Radiation from the X-Ray Tube Filtration Collimation and Beam Alignment Source-to-Image Receptor Distance Source-to-Skin Distance Exposure Switch for Radiography Equipment Specifications for Fluoroscopy Filtration Collimation Source-to-Skin Distance Exposure Switch Cumulative Timer Rad Tech’s Guide to Radiation Protection, Second Edition. Euclid Seeram. © 2020 John Wiley & Sons Ltd. Published 2020 by John Wiley & Sons Ltd. 0004398316.INDD 101 7/8/2019 2:04:09 PM 102 Rad Tech’s Guide to Radiation Protection Protective Curtain Table and Bucky-Slot Shielding Accessory Protective Clothing Procedures for Minimizing Dose to Patients and Personnel Procedural Factors for Minimizing Dose to Patients in Radiography and Fluoroscopy Diagnostic Reference Levels (DRL) Procedural Factors for Minimizing Dose to Personnel Shielding: Design of Protective Barriers Quality Assurance: Dose Management and Optimization Dose Management Dose Optimization T he factors affecting dose in radiography and fluoroscopy have been described in Chapters 6 and 7, respectively. This chapter outlines the techniques and methods for dose management. Dose management examines various methods to reduce the dose to patients, personnel, and members of the public. It is also guided by the two triads of radiation protection: time, shielding, and distance (radiation protection actions) and justification, optimization, and dose limitation (radiation protection principles) described in Chapter 5. The purpose of this chapter is to summarize the major federal regulations for dose management in radiology, including the guidelines and recommendations for equipment specifications, procedures for minimizing the dose to patients and personnel, and shielding. These topics are important to the technologist as they provide the technologist with the techniques that are mandatory to optimize the examination in an effort to reduce the dose to all individuals who may be exposed to radiation in the radiology department. 0004398316.INDD 102 7/8/2019 2:04:09 PM Dose Management Regulations and Optimization 103 Federal Regulations for Dose Management Safety Reports for Guidelines and Responsibilities The guidelines and recommendations for dose management are outlined in various reports. It is essential for users of diagnostic X‐ray equipment to consult the radiation safety codes for their respective countries. In this book, the regulations from the following are cited: ◼◼ National Council on R adiation Protection and Measurements (NCRP) Report No. 102 (NCRP 2015). ◼◼ Code of Federal Regulations (CFR) Title 21: Performance Standards for Ionizing Radiation Emitting Products (DHHS 2018). It is not within the scope of this text to address details of these reports. The student and instructor must refer to them for additional topics not covered here. Specifically, this chapter focuses on major recommendations for equipment specifications, procedures for minimizing dose to patients and personnel, and, finally, shielding requirements for radiology. Definition of Terms in Safety Reports In the NCRP Report No. 102, the terms shall and should are used in the recommendations. The exact meanings are as follows: ◼◼ Shall and shall not are used to indicate that adherence to the recommendation is considered necessary to meet accepted standards of protection. ◼◼ Should and should not are used to indicate a prudent practice to which exceptions may be occasionally made in appropriate circumstances (NCRP 1989, p. 2). 0004398316.INDD 103 7/8/2019 2:04:09 PM 104 Rad Tech’s Guide to Radiation Protection Equipment Specifications for Radiography The regulations for equipment specifications are obviously intended for manufacturers of radiation emitting devices such as the X‐ray machine. There are specifications particularly intended to protect both patients and operators when X‐ray machines are producing radiation. The specifications for radiographic equipment to be summarized here are those relating to the X‐ray control panel, leakage radiation from the X‐ray tube, filtration, collimation, source‐to‐image receptor distance (SID), source‐to‐skin distance (SSD), and the exposure switch for fixed and mobile radiographic systems. X-Ray Control Panel The X‐ray control panel features warning signs, markings, indicator lights, and various icons to indicate when the machine is being used and to ensure that exposures occur when the operator conducts the examination. The specifications are such that the control panel must: ◼◼ Bear visible signs indicating that only authorized and qual- ified personnel are permitted to operate the equipment. ◼◼ Show controls, meters, and lights indicating the opera- tion of the various machine parameters, such as a visible light or audible tone when the exposure is made (when the beam is on). Leakage Radiation from the X-Ray Tube The X‐ray tube housing must be lined with lead to reduce leakage radiation from the tube such that, at a distance of 1 m from the X‐ray tube, the leakage radiation must be less than 1 mGy/h (100 mR/h) 0004398316.INDD 104 7/8/2019 2:04:09 PM Dose Management Regulations and Optimization 105 Filtration Remember that the purpose of filtration is to protect the patient by removing low‐energy photons from the X‐ray beam. The recommendations from the minimum total filtration (inherent and added) in the useful beam are: ◼◼ 2.5 mm aluminum equivalent when the tube is operating above 70 kV. ◼◼ 1.5 mm aluminum equivalent when the tube is operating between 50 and 70 kV. ◼◼ 0.5 mm aluminum equivalent when the tube is operating below 50 kV. Note that the thickness of the filter depends on the kV and increases when the kV increases. Collimation and Beam Alignment Collimation is intended to protect the patient by restricting the beam to the clinical area of interest. The recommendation for collimation and beam alignment is that the X‐ray field and the light beam must be aligned to within 2% of the SID at the center of the image receptor. Source-to-Image Receptor Distance The SID is important in terms both of image quality and radiation dose. Examinations must be carried out at the correct SID (a chest X‐ray should be performed at 180 cm [72 in.]). The recommendation is as follows: ◼◼ An SID indicator (tape measure or laser measurement system) must be provided with all X‐ray systems and it must be accurate to within 2% of the SID used. ◼◼ The SID for tabletop work in radiography should not be less than 100 cm (40 in.). 0004398316.INDD 105 7/8/2019 2:04:09 PM 106 Rad Tech’s Guide to Radiation Protection Source-to-Skin Distance The SSD affects dose to the patient given that it determines the concentration of photons per unit area of the surface of the patient. The NCRP recommendation is that the SSD shall not be less than 30 cm (12 in.) and should not be less than 38 cm (15 in.). Exposure Switch for Radiography The purpose of the exposure switch is to allow the technologist to make an exposure for image formation. Recommendations for the exposure switch are: ◼◼ For fixed radiographic equipment, the exposure switch must be on the control panel to ensure that the operator remains in the control booth during the exposure. ◼◼ The switch must be a “dead man” switch. That is, pressure must be applied to the switch for the exposure to occur. ◼◼ For mobile radiography units, the exposure switch shall be so arranged on a long cord to allow the operator to stand at least 2 m (6 ft) from the patient and the unit. Equipment Specifications for Fluoroscopy The specifications for the fluoroscopic equipment are numerous and, therefore, only the major categories are reviewed here. These specifications include filtration, collimation, SSD, exposure switch, cumulative timer, protective curtain, table and Bucky‐slot shielding, and accessory protective clothing. Filtration Filtration of the beam used in fluoroscopy is mandatory, and since high kV beams are generally used in fluoroscopic 0004398316.INDD 106 7/8/2019 2:04:09 PM Dose Management Regulations and Optimization 107 examinations, the total filtration must be at least a 2.5 aluminum equivalent to protect the patient from low‐energy photons. Collimation The NCRP recommendations for the collimator in f luoroscopy are: ◼◼ The collimator shall be coupled and centered to the image receptor and should be confined to the receptor at any SID. ◼◼ “For spot‐film radiography, the shutters shall automatically change to the required field size before each exposure” (NCRP 1989, p. 15). Source-to-Skin Distance In fluoroscopy, the SSD shall not be less than 38 cm (15 in.) for stationary fluoroscopic units and shall not be less than 30 cm (12 in.) for mobile fluoroscopic units. Exposure Switch The exposure switch for fluoroscopy must be a dead man type of switch. Both the foot switch and the switch on the spot‐film device are the dead man type of switch. Cumulative Timer This timer records the beam‐on time during the examination. ◼◼ The timer shall provide the operator with an audible or visual signal when five minutes of beam‐on time have elapsed. ◼◼ The signal should last at least 15 seconds, at which time it must be reset to continue fluoroscopy. 0004398316.INDD 107 7/8/2019 2:04:09 PM 108 Rad Tech’s Guide to Radiation Protection Protective Curtain A protective lead curtain is part of the fluoroscopic equipment that hangs from the spot‐film device to reduce and prevent the scattered radiation from the patient from reaching the radiologist. ◼◼ The dimensions of the curtain should be not less than 45.7 cm × 45.7 cm (18 in. × 18 in.). ◼◼ The curtain should have at least 0.25 mm lead‐equivalent thickness. Table and Bucky-Slot Shielding The Bucky slot is an opening on the table about 5 cm wide that allows the operator to move the Bucky tray to one end of the table when fluoroscopy is being conducted. The Bucky slot is shielded by a length of metal that covers the opening to prevent scattered radiation from reaching the operator at the gonadal level. ◼◼ Bucky‐slot shielding should have a lead‐equivalent thick- ness of at least 0.25 mm. Similarly, the fluoroscopic table must also provide shielding to prevent scattered radiation from reaching personnel. ◼◼ The table should have a lead‐equivalent thickness of 0.25 mm to provide protection from scattered radiation. Accessory Protective Clothing These items include lead aprons, thyroid shields, and protective gloves worn by operators. Recommendations are as follows: ◼◼ Protective aprons shall have at least a 0.5 mm lead‐ equivalent thickness. 0004398316.INDD 108 7/8/2019 2:04:09 PM Dose Management Regulations and Optimization 109 ◼◼ Protective thyroid shields shall have at least a 0.5 mm lead‐equivalent thickness. ◼◼ Protective gloves shall have a lead‐equivalent thickness of at least 0.25 mm. Procedures for Minimizing Dose to Patients and Personnel There are a number of practices and procedures to reduce the dose to the patients and personnel and to keep exposures according to the as low as reasonable achievable (ALARA) philosophy. Only the more commonplace procedures are reviewed here. Technologists must refer to the safety codes for more detailed information. Procedural Factors for Minimizing Dose to Patients in Radiography and Fluoroscopy There are several factors under the direct control of the technologist that are intended to reduce the dose to the patient during the conduct of the examination. It is not within the scope of this book to discuss all of these factors. However, the following actions are significant and illustrative: ◼◼ The radiologist should be consulted to ensure that the examination is warranted, especially in situations that are confusing. ◼◼ Selection of correct image receptor should be appropriate to the examination, since the dose is inversely proportional to the sensitivity of the image receptor. Faster image receptor systems are now used to control the dose to the patient without compromising image quality. ◼◼ Selection and use of the best possible exposure technique factors should keep the dose as low as 0004398316.INDD 109 7/8/2019 2:04:09 PM 110 Rad Tech’s Guide to Radiation Protection reasonably ­achievable without compromising image quality. Generally, high‐kV techniques reduce the dose to the patient, as described in Chapter 6. ◼◼ The correct use of automatic exposure control can play a significant role in dose reduction, specifically with regard to repeat examinations. ◼◼ Repeat examinations should be kept to a minimum. Errors in positioning, exposure technique factors, collimation, and patient motion are major factors that affect repeat rates. ◼◼ Collimation to the size of the image receptor or smaller is the preferred action, and evidence of collimation on the image should be shown. Collimation alone can reduce the genetically significant dose (population gonadal dose) by 65%. ◼◼ The smallest image receptor size should be chosen to match the diagnostic goal of the examination. ◼◼ The optimal SID appropriate to the anatomy being imaged should be used. ◼◼ Shielding should always be used to protect radiosensitive organs. Careful placement of the shield is mandatory to protect organs, while not compromising the goals of the examination. During fluoroscopy, paying careful attention to the following factors can minimize the dose to the patient: ◼◼ The patient must understand the nature of the examina- tion to avoid repeat exposures. Understanding breathing instructions and being asked to assume various positions are examples. ◼◼ Fluoroscopy must be carried out by an appropriately trained individual, such as a radiologist. ◼◼ Although not under the direct control of the technologist, the fluoroscopy time should be kept as short as possible. 0004398316.INDD 110 7/8/2019 2:04:09 PM Dose Management Regulations and Optimization 111 ◼◼ The exposure rate in fluoroscopy must not exceed the recommended limits. ◼◼ Because the radiologist performs the examination, he or she should be certain that the beam is filtered and collimated, and that the fluoroscopic exposure technique is consistent with the clinical objectives of the examination. Diagnostic Reference Levels (DRL) DRLs were briefly outlined in Chapter 5. The NCRP has prepared a report that specifically deals with DRLs for different modalities and examinations – NCRP Report No. 172, Reference Levels and Achievable Doses in Medical and Dental Imaging: Recommendations for the United States (NCRP 2015). Procedural Factors for Minimizing Dose to Personnel To achieve the goal of reducing the dose to personnel, technologists must work within the ALARA philosophy. Examples of recommendations to ensure personnel dose reduction are: ◼◼ Only essential personnel must be present in an X‐ray room during the exposure. ◼◼ Technologists must remain in the control booth during radiographic exposures and must wear protective aprons when the situation makes this impossible. ◼◼ Technologists must always pay attention to patients by observing them through the shielded transparent window in the control booth during the exposure. ◼◼ All room doors must be closed during the exposure to prevent scattered radiation from reaching personnel in close proximity to the room. ◼◼ Radiology personnel (including technologists) must refrain from holding patients during an examination. Immobilizing devices should be used or other nonradiology personnel. 0004398316.INDD 111 7/8/2019 2:04:09 PM 112 Rad Tech’s Guide to Radiation Protection In the latter case, these individuals must be provided with protective clothing. ◼◼ Personnel dosimeters must always be worn during scheduled periods of work in the radiology department or when performing operating room and mobile radiographic examinations. During fluoroscopic procedures: ◼◼ Aprons must always be worn during the fluoroscopic por- tion of the examination. ◼◼ Technologists should stand a few steps away from the patient during fluoroscopic exposures unless the situation warrants that someone assists the patient directly. During mobile radiography: ◼◼ Technologists must stand the maximum distance allowed by the exposure cord (2 m) from the X‐ray machine and the patient. ◼◼ Protective aprons must always be worn, or the technologist can stand behind a portable shield if one is available. ◼◼ Direct the primary beam to the patient only and be certain that no others will be exposed to the useful beam. Shielding: Design of Protective Barriers Shielding is a radiation protection action and a design criterion that is intended to protect patients, personnel, and members of the public. Shielding includes specific area shielding (protecting radiosensitive organs) and protective barriers (walls) positioned between the source of radiation and the individual. This type of shielding is specifically intended to protect personnel and members of the public from unnecessary radiation. 0004398316.INDD 112 7/8/2019 2:04:09 PM Dose Management Regulations and Optimization 113 ◼◼ Because X‐ray rooms are in close proximity to other rooms that are occupied by personnel (lounges and offices) and by patients (waiting rooms and corridors), the walls of the X‐ray room must be shielded. ◼◼ X‐ray rooms are shielded with lead in most cases (concrete can also be used). ◼◼ The thickness of the lead depends on whether the wall is exposed to the primary beam (primary protective barriers) or to scattered radiation (secondary protective barrier). ◼◼ Lead may not be used for shielding in secondary barriers since its four layers of thickness may be too thin (<0.4 mm). Therefore, a lead acrylic gypsum may be used (⅝ inch gypsum board with ½ inch plate glass will offer adequate protection). ◼◼ The control booth is considered a secondary protective barrier and is subject to the same lead thickness criterion for secondary barriers (the primary beam must never be directed toward the control booth). There are several factors that affect the thickness of protective barriers in radiology. These factors include the exposure rates for controlled and uncontrolled areas occupied by individuals, the distance between the radiation source and the barrier, workload, occupancy factor, use factor, and the kV for examinations. ◼◼ A controlled area is an area in which an individual is occupationally exposed and includes radiology personnel and as well as patients. Barriers for controlled areas must minimize the exposure rate to less than 1 mSv/wk (100 mrem/wk). ◼◼ An uncontrolled area is one occupied by any individual. Barriers for uncontrolled areas must reduce the exposure rate to that of members of the public, that is 1 mSv/yr (100 mrem/yr). ◼◼ Barriers for uncontrolled areas contain more lead than do barriers for controlled areas. 0004398316.INDD 113 7/8/2019 2:04:09 PM 114 Rad Tech’s Guide to Radiation Protection ◼◼ The workload refers to the number of examinations per- formed per week, expressed as milliampere‐minutes per week (mA‐min/wk). ◼◼ The occupancy factor refers to the time that the area is occupied, expressed as a fraction of the work week. Levels of occupancy can be full (1), partial (¼), and occasional ( 116) occupancy. ◼◼ The use factor is the fraction of time during which the primary beam is on and aimed at the barrier. Use factors are provided for levels of full use (1), partial use (¼), and occasional use ( 116). ◼◼ The maximum and average kV must also be known to calculate barrier thickness. The barrier thickness can be determined by referring to precalculated shielding requirement tables or by performing a calculation using the data for the various factors previously identified. Quality Assurance: Dose Management and Optimization Quality assurance (QA) includes quality administration and quality control (QC). Quality administration deals with the people and management of the entire QA program; QC deals with the technical aspects of machine performance. Dose Management The goals of QA and QC are to: ◼◼ Reduce the dose to the patient. ◼◼ Ensure optimal image quality to facilitate diagnostic interpretation. ◼◼ Reduce costs to the institution and the consumer. 0004398316.INDD 114 7/8/2019 2:04:10 PM Dose Management Regulations and Optimization 115 QC ensures dose management and optimization through its three major steps of: ◼◼ Acceptance testing, during which new equipment is tested to ensure that manufacturer’s specifications are met. ◼◼ Routine performance or carrying out QC tests on var- ious parameters that affect patient dose and image quality. Specifically, equipment parameters are evaluated using a defined set of tools and procedures. ◼◼ Error correction, whereby the problems detected during routine performance testing are remedied to ensure proper functioning of the equipment. Additionally, QC uses an important concept known as the tolerance limit or acceptance criterion. ◼◼ Tolerance limits can be assessed qualitatively (as a pass– fail) or quantitatively (as a ± value). ◼◼ If the QC test results fall within the tolerance limit, then the parameter under investigation is deemed acceptable and the equipment can be used to image the patient. ◼◼ If the test results fall outside the tolerance limits, the performance criterion has not been met and the equipment must be repaired to produce acceptable image quality. ◼◼ The NCRP tolerance limits for kV accuracy, for example, are ±5% and less over a limited range (±2 kV for 60–100 kV). ◼◼ The NCRP tolerance limit for the light field and X‐ray field alignment is ±3% of the SID. ◼◼ QC tests should be conducted on all the variables that affect image quality and dose, including collimation, filtration, focal spot size, kVp accuracy, mA linearity, and exposure timer accuracy, among others. A QA–QC program is a management operation that ensures optimal image quality with reduced radiation dose to patients 0004398316.INDD 115 7/8/2019 2:04:10 PM 116 Rad Tech’s Guide to Radiation Protection and personnel through a performance evaluation of the factors affecting both image quality and radiation dose. Dose Optimization In addressing the ALARA principle and the need to ensure there is a balance between acquiring high‐quality diagnostic images with the least amount of dose, the literature most often uses two terms: reduction and optimization. Reduction means to “reduce or diminish in size, amount, extent, or number.” Optimization means “an act, process, or methodology of marking something (as a design, system, or decision) as fully perfect, functional, or effective as possible” (Reduction, Optimization. Merriam‐ Webster Dictionary. Online English Language Dictionary. www. merriam‐webster.com/dictionary). An article in the journal Radiation Protection Dosimetry dedicated to optimization strategies in medical imaging (Mattsson 2005) identified at least four important requirements for dose and image‐quality optimization research. First, ensure patient safety. Second, determine the level of image quality required for a particular diagnostic task. The third point to keep in mind is to acquire images at various exposure levels from high to low and in such a manner that accurate diagnosis can still be made. Finally, reliable and valid methodologies for the dosimetry, image acquisition, and evaluation of image quality using human observers must be used, keeping in mind the nature of the detection task. 0004398316.INDD 116 7/8/2019 2:04:10 PM 10 Pregnancy Essential Radiation Protection Considerations Chapter at a Glance Rationale for Radiation Protection in Pregnancy Factors Affecting Dose to the Conceptus Estimating the Dose to the Conceptus Continuing/Terminating a Pregnancy After Exposure Dose Reduction Techniques for Pregnant Patients The Pregnant Worker Rights to Privacy Dose Limits and Personnel Monitoring Protective Aprons for Pregnant Workers Policies for Pregnant Workers B eing of childbearing age and being pregnant are two situations that warrant special radiation protection considerations, especially for in utero exposure in diagnostic radiology. Rad Tech’s Guide to Radiation Protection, Second Edition. Euclid Seeram. © 2020 John Wiley & Sons Ltd. Published 2020 by John Wiley & Sons Ltd. 0004398317.INDD 117 7/8/2019 2:06:42 PM 118 Rad Tech’s Guide to Radiation Protection This topic is of vital significance to the radiologic technologist for two reasons: ◼◼ There are known bioeffects of radiation exposure to the conceptus; that is, any product of conception (embryo or fetus). ◼◼ Many technologists are at the childbearing age and several others may be pregnant while working in the radiology department. The purpose of this chapter is to summarize radiation protection considerations for pregnant patients and pregnant workers. Specifically, the effects of prenatal exposure will be listed and the factors affecting fetal dose in radiology, fetal dose estimation, and recommendations following in utero exposure will be highlighted. Additionally, regulations for pregnant workers, including rights to privacy, dose limits, and maternity aprons and policies, will be outlined. Rationale for Radiation Protection in Pregnancy It is well known that radiation can cause injury to the conceptus. The effects of prenatal exposure to radiation is as a function of gestational age (ACR‐SPR 2018). Data from animal experiments and survivors of the nuclear bombing of Hiroshima and Nagasaki (HN) (classified as a high‐dose event) suggest the following (Seeram and Brennan 2017; Sreetharan et al. 2017): ◼◼ Prenatal death results before embryonic implantation. ◼◼ Head size is small in the children of HN survivors. ◼◼ The most sensitive period for this effect is from 2 to 15 weeks after conception. 0004398317.INDD 118 7/8/2019 2:06:42 PM Pregnancy 119 ◼◼ Mental retardation. ◼◼ Radiation‐induced malignancy As noted by Bushong (2017), “… these abnormalities are based on doses greater than 1 Gy (in tissue) with minimal reported doses in animal experiments at approximately 100 mGy. No evidence at the human or animal level indicates that the levels of radiation exposure experienced occupationally or medically are responsible for any such effects on fetal growth or development.” If a pregnant patient must be imaged, then special precautions must always be taken. These precautions are listed later in this chapter. Factors Affecting Dose to the Conceptus The same factors that affect patient dose in radiography and fluoroscopy also affect dose to the conceptus. However, as early as 1999, Parry et al. emphasized two factors that deserve special attention: ◼◼ Direct exposure. For certain examinations such as the abdomen, pelvis, and lumbar spine, the fetus can be exposed directly to the primary beam. In this case, the dose to the fetus is extremely high. Lead shielding will not serve any useful purpose. ◼◼ Indirect exposure. For examinations such as the extremities and skull, the fetus will receive radiation scattered inside the womb. In this case, the dose to the fetus is less compared to direct exposure. A lead shield will not serve a useful purpose because the dose is from internal scattered radiation 0004398317.INDD 119 7/8/2019 2:06:42 PM 120 Rad Tech’s Guide to Radiation Protection Estimating the Dose to the Conceptus During situations in which the patient is concerned about the actual dose to her conceptus, the dose can be estimated and appropriate actions may be taken. These actions include at least two choices available to the patient: ◼◼ Continue the pregnancy to term. ◼◼ Terminate the pregnancy. The fetal dose can be estimated and requires a physicist to perform the calculations. It is not within the scope of this chapter to provide details of such calculations; the interested reader should refer to Solomon et al. (2014) for such details. Several factors must be known to provide a reasonable estimation of the dose, such as the output intensity, half‐value layer, location and number of views for radiography, and beam‐on time for fluoroscopy, among others. Additionally, the fetal age at the time of the exposure, patient position, patient size (thickness), and fetal depths must also be known. Continuing/Terminating a Pregnancy After Exposure The notion of continuing or terminating a pregnancy is a matter between the patient and her physician and requires a benefit– risk analysis. Such risk assessment is based on knowing the absorbed dose and the gestational age. These two quantities are needed before any communications with the patient (ACR‐SPR 2018). Absorbed doses are discussed for radiographic, fluoroscopic, and computed tomography (CT) examinations elsewhere (ACR‐SPR 2018) 0004398317.INDD 120 7/8/2019 2:06:42 PM Pregnancy 121 Dose Reduction Techniques for Pregnant Patients The following techniques are intended to minimize the dose to a patient who is pregnant or potentially pregnant: ◼◼ Always check for pregnancy. ◼◼ Elective radiography (examinations that do not contribute to the diagnosis with respect to the patient’s current health problems) must not be performed. ◼◼ Use signs and questionnaires to help the patient inform operators about her state of pregnancy. ◼◼ If a pregnant patient must be irradiated, then the technologist should: ◼◼ Collimate the beam only to the clinical area of interest. ◼◼ Use high‐kV techniques. ◼◼ Ensure that the radiation beam has the appropriate filtration. ◼◼ Place gonadal shielding effectively so as not to compromise image quality. ◼◼ Execute all related departmental protocols regarding in utero exposure such as: ◼◼ Keeping the f luoroscopy time as short as possible. ◼◼ Reducing the number of images taken. ◼◼ Checking for the date of the last menstrual period. The Pregnant Worker There are specific radiation protection regulations and guidelines for pregnant workers in radiology. This section will consider rights to privacy, dose limits, protective clothing, and maternity policies. 0004398317.INDD 121 7/8/2019 2:06:42 PM 122 Rad Tech’s Guide to Radiation Protection Rights to Privacy Regulations from the National Research Council (NRC) regarding a pregnancy “have found their way into state regulations for X‐ray workers.” Foremost in consideration is the right to privacy for the individual: ◼◼ A pregnant technologist should notify the department of her pregnancy. Dose Limits and Personnel Monitoring There are special rules and dose limits for the conceptus once the pregnancy is declared. ◼◼ For a pregnant worker, the dose limit to an embryo or fetus is 5 mSv (0.5 rem) (Bushong 2017) over the entire gestational period. This is a dose level “that most technologists will not reach regardless of pregnancy” (Bushong 2017). ◼◼ The reading from an unshielded dosimeter (worn on the trunk of the individual) is used to determine the dose to the conceptus. ◼◼ For pregnant workers who wear protective aprons, a dosimeter can be worn outside the apron, as well as one worn under the apron. ◼◼ A dosimeter worn beneath the shielding can provide a reliable estimate of the dose to the conceptus. Protective Aprons for Pregnant Workers Specially designed protective lead aprons are commercially available for pregnant workers. The following points are important with respect to maternity aprons: ◼◼ Wrap‐around aprons are preferable to attenuate any radi- ation striking the back of the mother. When the dosimeter 0004398317.INDD 122 7/8/2019 2:06:42 PM Pregnancy 123 is in the front of the mother, an unshielded back would result in the radiation being attenuated by the embryo or fetus before it is detected by the dosimeter. ◼◼ A lead apron with a 0.5 mm lead‐equivalent thickness will attenuate the radiation striking the apron by 90% at 75 kV. ◼◼ Lead aprons with a 1 mm lead‐equivalent thickness are currently available. Policies for Pregnant Workers Employer policies for pregnant workers should be available and should focus on job expectations so as to eliminate any notion of special treatment that may subject pregnant workers to job discrimination. ◼◼ Policies should be intended to minimize the dose to the conceptus during normal periods of work. ◼◼ Policies should ensure, through education and counseling, that the pregnant worker perform her duties with a clear understanding of the risks of working while pregnant. Resources are currently available to help with education and counseling. One such report is that of the American College of Radiology (ACR) and the Society for Pediatric Radiology (SPR) entitled ACR–SPR Practice Parameter for Imaging Pregnant or Potentially Pregnant Adolescents and Women with Ionizing Radiation (ACR–SPR 2018). 0004398317.INDD 123 7/8/2019 2:06:42 PM 0004398317.INDD 124 7/8/2019 2:06:42 PM 1 References AAPM (American Association of Physicists in Medicine). (2009). An Exposure Indicator for Digital Radiography. AAPM. Report No. 116. College Park, MD. AAPM (American Association of Physicists in Medicine) (2011). Size‐ Specific Dose Estimates (SSDE) in Pediatric and Adult Body CT Examinations. AAPM. Report No. 204. College Park, MD. ACR‐SPR (American College of Radiology‐Society for Pediatric Radiology). (2018). ACR‐SPR Practice Parameter for Imaging Pregnant or Potentially Pregnant Adolescents and Women with Ionizing Radiation. American College of Radiology. Beister, M., Kolditz, D., and Kalender, W.A. (2012). Iterative reconstruction methods in X ray CT. Phys. Med. 28 (2): 94–108. Bushberg, J.T., Seibert, J.A., Leidholdt, E.M. et al. (2012). The Essential Physics of Medical Imaging, 3e. Philadelphia, PA: Lippincott Williams & Wilkins. Bushong, S. (2017). Radiologic Science for Technologists: Physics, Biology and Protection, 11e. St Louis, MO: Mosby‐Elsevier Inc. Christner, J.A., Zavaletta, V.A., Eusemann, C.D. et al. (2010). Dose reduction in helical CT: dynamically adjustable z‐axis X‐ray beam collimation. Am. J. Roentgenol. 194 (1): W49–W55. https://doi. org/10.2214/AJR.09.2878. Coakley, F.V., Gould, R., Yeh, B.M. et al. (2011). CT radiation dose: What can you do right now in your practice? Am. J. Roentgenol. 196 (3): 619–625. Rad Tech’s Guide to Radiation Protection, Second Edition. Euclid Seeram. © 2020 John Wiley & Sons Ltd. Published 2020 by John Wiley & Sons Ltd. 0004398318.INDD 125 7/8/2019 2:08:10 PM 126 References DHHS (US Department of Health and Human Services). (2018). Code of Federal Regulations (CFR) Title 21: Performance Standards for Ionizing Radiation Emitting Products. DHHS, Food and Drug Administration (FDA), Washington, DC. Don, S., Whiting, B.R., Rutz, L.J. et al. (2012). New exposure indicators for digital radiography simplified for radiologists and technologists. Am. J. Roentgenol. 199: 1337–1341. Fleischmann, D. and Boas, F.E. (2011). Computed tomography: old ideas and new technology. Eur. Radiol. 21 (3): 510–517. Goo, H.W. (2012). CT radiation dose optimization and estimation: an update for radiologists. Korean J. Radiol. 13 (1): 1–11. Health Canada. (2008). Radiation Protection in Radiology – Large Facilities. Ottawa, ON: Ministry of Health. Safety Code 35. Hendee, W.R. and O’Connor, M.K. (2012). Radiation risks in medical imaging: separating fact from fantasy. Radiology 264 (2): 312–320. https://doi.org/10.1148/radiol.12112678. Huda, W. and Slone, R. (1995). Review of Radiologic Physics. Baltimore, MD: Williams and Wilkins. IEC (International Electrotechnical Commission). (2008). Medical electrical equipment – Exposure index of digital X‐ray imaging systems – Part 1: Definitions and requirements for general radiography. Geneva, Switzerland: IEC. International Standard IEC 62494‐1: 2008. ICRP (International Commission on Radiological Protection) (2007). ICRP Publication No. 103. The recommendations of the international commission on radiological protection. Ann ICRP 37 (2–4): 1–332. Kaza, R.K., Platt, J.F., Goodsitt, M.M. et al. (2014). Emerging techniques for dose optimization in abdominal CT. Radiographics 34 (1): 4–17. Maldjian, P.D. and Goldman, A.R. (2013). Reducing radiation dose in body CT: primer on dose metrics and key CT technical parameters. Am. J. Roentgenol. 200 (4): 741–747. Mattsson, S. (2005). Optimization strategies in medical X‐ray imaging. Radiat. Prot. Dosim. 114 (1–3): 1–3. McCollough, C. (2019). Computed tomography technology and dose in the 21st century. Health Phys. 116 (2): 157–162. McNitt‐Gray, M.F. (2002). AAPM/RSNA physics tutorial for residents: topics in CT: radiation dose in CT. Radiographics 22 (6): 1541–1553. 0004398318.INDD 126 7/8/2019 2:08:10 PM References 127 NCRP (National Council on Radiation Protection and Measurements). (1977). Medical Radiation Exposure of Pregnant and Potentially Pregnant Women. Bethesda, MD: NCRP. Report No. 54. NCRP (National Council on Radiation Protection and Measurements). (1989). Exposure of the U.S. Population from Occupational Radiation. NCRP. Report No. 101. Bethesda, MD. NCRP (National Council on Radiation Protection and Measurements). Limitation of Exposure to Ionizing Radiation. 1993. Bethesda, MD: NCRP. Report No. 116. NCRP (National Council on Radiation Protection and Measurements). (2015). Medical X‐Ray, Electron Beam and Gamma‐Ray Protection for Energies Up to 50 MeV (Equipment Design, Performance and Use). Bethesda, MD: NCRP. Report No. 102. NCRP (National Council on Radiation Protection and Measurements). (2015). Reference Levels and Achievable Doses in Medical and Dental Imaging: Recommendations for the United States. NCRP. Report No. 172. Bethesda, MD. Oda, S., Utsunomiya, D., Funama, Y. et al. (2011). A low tube voltage technique reduces the radiation dose at retrospective ECG‐gated cardiac computed tomography for anatomical and functional analyses. Acad. Radiol. 18 (8): 991–999. Parry, B.A., Glaze, S.A., and Archer, B.R. (1999). Typical patient radiation doses in diagnostic radiology. Radiographics 19: 1289–1302. Qiu, D. and Seeram, E. (2016). Does iterative reconstruction improve image quality and reduce dose in computed tomography? Radiol Open J. 1 (2): 42–54. Seeram, E. (2016). Computed Tomography: Physical Principles, Clinical Applications and Quality Control. St Louis, MO: Elsevier. Seeram, E. (2018). Computed tomography – a technical review. Radiol. Technol. 89 (3): 279–302. Seeram, E. (2019). Digital Radiography: Physical Principles and Quality Control. Springer Nature, Singapore Pvt. Ltd. Seeram, E. and Brennan, P. (2017). Radiation Protection in Diagnostic X‐ray Imaging. Burlington, MA: Jones and Bartlett Learning. Seibert, J.A. and Morin, R.L. (2011). The standardized exposure index for digital radiography: an opportunity for optimization of radiation dose to the pediatric population. Pediatr. Radiol. 41: 573–581. Solomon, G., Stratakis, J., and Damilakis, J. (2014). How to estimate conceptus radiation dose from radiographic, fluoroscopic and 0004398318.INDD 127 7/8/2019 2:08:10 PM 128 References fluoroscopically guided interventional procedures? (review course talk for the concert project). Phys. Med. 30, Supplement 1, e‐10. Sreetharan, S., Thome, C., Tharmalingam, S. et al. (2017). Ionizing radiation exposure during pregnancy: effects on postnatal development and life. Radiat. Res. 187: 647–658. Tran, L. and Seeram, E. (2017). Current perspectives on the use of the linear non‐threshold (LNT) model in radiation protection. Int. J Radiol. Med. Imag. 3: 123. Travis, E. (1997). Bioeffects of radiation. In: Radiation Protection, Chapter 4 (ed. E. Seeram). Philadelphia, PA: Lippincott‐Raven Publishers. Wolbarst, A.B., Capasso, P., and Wyant, A.R. (2013). Medical Imaging: Essentials for Physicians. Hoboken, NJ: Wiley‐Blackwell. 0004398318.INDD 128 7/8/2019 2:08:10 PM Index absorbed dose, quantifying ionizing radiation 32 acceptance criteria, quality control (QC) 115 accessory protective clothing, equipment specifications for fluoroscopy 108–109 American College of Radiography (ACR), diagnostic reference levels (DRLs) 63 antiscatter grids digital radiography (DR) 74–75 fluoroscopy 81, 86 ‘as low as reasonably achievable’ (ALARA) see also dose optimization – ALARA radiation protection principle 4, 5, 10–11, 58–59 ATCM see automatic tube current modulation attenuation, X‐ray 20–23 beam hardening 22 Compton scattering 24–26 definition 20–22 factors affecting attenuation 22–23 heterogeneous beams 21–22 automatic brightness control (ABC), fluoroscopy 84 automatic exposure‐rate control (AERC), fluoroscopy 84 automatic tube current modulation (ATCM), computed tomography (CT) 98 automatic voltage selection, computed tomography (CT) 98 beam alignment, equipment specifications for radiography 105 beam collimation see collimation beam energy digital radiography (DR) 71–72 fluoroscopy 82–83 beam hardening, diagnostic X‐rays 22 beam‐on time, fluoroscopy 83–84 BEIR (Biological Effects of Ionizing Radiation Committee) 57 bioeffects types 55–56 Biological Effects of Ionizing Radiation Committee (BEIR) 57 Rad Tech’s Guide to Radiation Protection, Second Edition. Euclid Seeram. © 2020 John Wiley & Sons Ltd. Published 2020 by John Wiley & Sons Ltd. 0004429202.INDD 129 7/8/2019 2:09:19 PM 130 Index biologic factors, radiation protection 3 biologic risks, quantifying 33–36 dose equivalent 34 effective dose 35 equivalent dose 35 radiation weighting factor 34 tissue weighting factor 35–36 bremsstrahlung (brems) radiation, diagnostic X‐rays 15, 16, 17 Bucky‐slot shielding, equipment specifications for fluoroscopy 108 CCD see charge‐coupled device characteristic radiation, diagnostic X‐rays 15, 17 charge‐coupled device (CCD), image intensifier fluoroscopy 80–81 collimation computed tomography (CT) 97 digital radiography (DR) 73 equipment specifications for fluoroscopy 107 equipment specifications for radiography 105 fluoroscopy 84–85 Compton scattering see also attenuation, X‐ray diagnostic X‐rays 24–26 computed tomography (CT) 89–100 automatic tube current modulation (ATCM) 98 automatic voltage selection 98 collimation 97 computed tomography dose index (CTDI) 94–95 definition 90 dose distribution 93–94 dose factors 96–99 dose length product (DLP) 95 dose metrics 94–96 dose optimization – ALARA 99–100 0004429202.INDD 130 effective dose (ED) 96 effective mAs 97 exposure technique factors 96–97 image quality index 98 iterative reconstruction algorithms 98–99 multislice CT scanners (MSCT) 93 multislice CT technology 93 Nobel Prize 91 overbeaming 97–98 overranging 97–98 physics 91–93 pitch 97 principles 91–93 scheme for patient exposure 6–8 size‐specific dose estimate (SSDE) 95 slice thickness 97 technology 91–93 computed tomography dose index (CTDI), computed tomography (CT) 94–95 computed tomography factors affecting dose, diagnostic radiology 10 computer, digital fluoroscopy 82 cosmic radiation, natural radiation source 29 criteria and standards, radiation protection 58–60 CT see computed tomography CTDI see computed tomography dose index cumulative timer, equipment specifications for fluoroscopy 107 definition of terms in safety reports 103 detective quantum efficiency (DQE), digital radiography (DR) 75–76 deterministic effects, bioeffects type 55–56 7/8/2019 2:09:19 PM Index diagnostic radiology computed tomography factors affecting dose 10 dose factors 8–10 fluoroscopic factors affecting dose 9 modalities 3 radiographic factors affecting dose 9 reasons for protection 3–4 diagnostic reference levels (DRLs) 62–64 see also dose optimization – ALARA American College of Radiography (ACR) 63 definition 63 dose minimizing 111 guidelines 64 International Commission on Radiologic Protection (ICRP) 63, 64 optimization of radiation protection (ORP) 62–64 diagnostic X‐rays 13–26 bremsstrahlung (brems) radiation 15, 16, 17 characteristic radiation 15, 17 Compton scattering 24–26 controlling beam quality and quantity 18–19 filtration 19 generator type 19 increasing kV and scatter production 26 mechanisms for creating X‐rays 14–16 photoelectric absorption (photoelectric effect) 23–24 scattering 24–26 source‐to‐image receptor distance (SID) 19 target material 19 X‐ray attenuation 20–23, 24–26 X‐ray interactions 23–26 0004429202.INDD 131 131 X‐ray production 13–14 X‐ray quality 18–19 X‐ray quantity 18–19 X‐ray spectrum 16–19 digital fluoroscopy 81–82 see also fluoroscopy components 81–82 computer 82 flat‐panel digital detector 81–82 image display monitor 82 scattered radiation grid 81, 86 X‐ray tube and generator 81 digital radiography (DR) 65–76 beam energy 71–72 collimation 73 definition 66 detective quantum efficiency (DQE) 75–76 dose factors 70–76 exposure indicator/index (EI) 67–68 exposure technique factors 72–73 vs film‐screen radiography (FSR) 66–68 filtration 72 image detector sensitivity or speed 75 kilovoltage or kV 71 patient size 73 radiographic antiscatter grids 74–75 scheme for patient exposure 6–8 source‐to‐image receptor distance (SID) 73–74 X‐ray generator 71–72 direct exposure dose factors 119 pregnancy 119 distance see also source‐to‐image receptor distance; source‐to‐skin distance radiation protection action 6, 59–60 DLP see dose length product 7/8/2019 2:09:19 PM 132 Index dose considerations dose factors in diagnostic radiology 8–10 pregnancy: radiation protection considerations 12 dose distribution, computed tomography (CT) 93–94 dose equivalent, quantifying biologic risks 34 dose estimation, pregnancy 120 dose factors computed tomography (CT) 10, 96–99 diagnostic radiology 8–10 digital radiography (DR) 65–76 direct exposure 119 fluoroscopy 9, 82–87 indirect exposure 119 pregnancy 119 radiographic factors 9 dose length product (DLP), computed tomography (CT) 95 dose limitation see also recommended dose limits radiation protection principle 5, 59 dose management regulations and optimization 101–116 definition of terms in safety reports 103 dose minimizing 109–112 equipment specifications for fluoroscopy 106–109 equipment specifications for radiography 104–106 federal regulations 103 quality assurance (QA) 114–116 shielding 112–114 dose management techniques 10–11 dose metrics, computed tomography (CT) 94–96 dose minimizing 109–112 see also dose optimization – ALARA 0004429202.INDD 132 diagnostic reference levels (DRLs) 111 fluoroscopy 110–112 procedural factors 111–112 radiography 109–110 dose optimization – ALARA see also dose minimizing computed tomography (CT) 99–100 procedural factors 111–112 quality assurance (QA) 116 radiation protection principle 4, 5, 10–11, 58–59 dose reduction 11, 116 see also dose minimizing; dose optimization – ALARA pregnancy 121 DQE see detective quantum efficiency DR see digital radiography DRLs see diagnostic reference levels earth sources (terrestrial radiation), natural radiation source 29 ED see effective dose education and training, dose management technique 11 effective dose, quantifying biologic risks 35 effective dose (ED), computed tomography (CT) 96 effective mAs, computed tomography (CT) 97 EI see exposure indicator/index equipment design and performance, dose management technique 10 equipment specifications for fluoroscopy 106–109 accessory protective clothing 108–109 Bucky‐slot shielding 108 collimation 107 cumulative timer 107 exposure switch 107 filtration 106–107 7/8/2019 2:09:19 PM Index protective curtains 108 source‐to‐skin distance (SSD) 107 equipment specifications for radiography beam alignment 105 collimation 105 dose management regulations and optimization 104–106 exposure switch for radiography 106 filtration 105 leakage radiation from the X‐ray tube 104 source‐to‐image receptor distance (SID) 105 source‐to‐skin distance (SSD) 106 X‐ray control panel 104 equivalent dose, quantifying biologic risks 35 exposure, quantifying ionizing radiation 31–32 exposure indicator/index (EI) digital radiography (DR) 67–68 standardized EI 68–69 exposure switch equipment specifications for fluoroscopy 107 equipment specifications for radiography 106 exposure technique factors computed tomography (CT) 96–97 digital radiography (DR) 72–73 factors affecting dose see dose factors FDA see Food and Drug Administration federal regulations see also dose management regulations and optimization dose management 103 f‐factor, quantifying ionizing radiation 33 film dosimetry, radiation measurement 36–37 0004429202.INDD 133 133 film‐screen radiography (FSR) 65 vs digital radiography (DR) 66–68 filtration diagnostic X‐rays 19 digital radiography (DR) 72 equipment specifications for fluoroscopy 106–107 equipment specifications for radiography 105 flat‐panel digital detector, digital fluoroscopy 81–82 fluoroscopic factors affecting dose, diagnostic radiology 9 fluoroscopy 77–88 see also digital fluoroscopy antiscatter grids 81, 86 automatic brightness control (ABC) 84 automatic exposure‐rate control (AERC) 84 beam energy 82–83 beam‐on time 83–84 collimation 84–85 components of fluoroscopic imaging systems 78–82 digital fluoroscopy 81–82 dose factors 82–87 dose minimizing 110–112 equipment specifications 106–109 image intensifier fluoroscopy 79–81 image magnification 86–87 last image hold 87 patient size 85–86 pregnancy: radiation protection considerations 12 pulsed fluoroscopy 87 reasons for importance 78 scattered radiation 87–88 scheme for patient exposure 6–8 source‐to‐skin distance (SSD) 85 tube current 83 wearing a personnel dosimeter 38 7/8/2019 2:09:19 PM 134 Index Food and Drug Administration (FDA) 57 framework for radiation protection, radiation protection actions 6 FSR see film‐screen radiography generator type, diagnostic X‐rays 19 heterogeneous beams, diagnostic X‐rays 21–22 high‐kVp techniques and increased filtration, pregnancy: radiation protection considerations 12 ICRP see International Commission on Radiologic Protection ICRU see International Commission on Radiological Units and Measurements image detector sensitivity or speed, digital radiography (DR) 75 image display monitor, digital fluoroscopy 82 image distributor, image intensifier fluoroscopy 80 image intensifier fluoroscopy 79–81 charge‐coupled device (CCD) 80–81 components 79–81 image distributor 80 image intensifier tube 80 spot‐film recording devices 81 television camera 80–81 television monitor 81 X‐ray tube and generator 79–80 image intensifier tube, image intensifier fluoroscopy 80 image magnification, fluoroscopy 86–87 image quality index, computed tomography (CT) 98 indirect exposure dose factors 119 pregnancy 119 0004429202.INDD 134 International Commission on Radiological Units and Measurements (ICRU) 56–57 International Commission on Radiologic Protection (ICRP) 56 diagnostic reference levels (DRLs) 63, 64 recommended dose limits 61 International System of Units (SI units), National Council of Radiation Protection and Measurements (NCRP) 31 ionization chamber, radiation measurement 36 iterative reconstruction algorithms, computed tomography (CT) 98–99 justification, radiation protection principle 5, 58 KERMA see kinetic energy released per unit mass kilovoltage or kV, digital radiography (DR) 71 kinetic energy released per unit mass (KERMA), quantifying ionizing radiation 32 last image hold, fluoroscopy 87 leakage radiation from the X‐ray tube, equipment specifications for radiography 104 linear energy transfer (LET), quantifying ionizing radiation 33 medical exposure to radiation 5, 30 medical X‐ray exposure, source of radiation exposure 30 members of the public see public exposure to radiation minimizing dose see dose minimizing multislice CT scanners (MSCT) 93 multislice CT technology 93 7/8/2019 2:09:19 PM Index National Council of Radiation Protection and Measurements (NCRP) 4, 12, 57 International System of Units (SI units) 31 NCRP Report No. 172, Reference Levels and Achievable Doses in Medical and Dental Imaging: Recommendations for the United States (NCRP 2015) 111 recommended dose limits 61 wearing a personnel dosimeter 38 National Radiological Protection Board (NRPB) 4 natural radiation sources 29 cosmic radiation 29 earth sources (terrestrial radiation) 29 radon 29 NCRP see National Council of Radiation Protection and Measurements NRPB see National Radiological Protection Board nuclear medicine examinations, source of radiation exposure 30 objectives, radiation protection 57–58 occupational exposure to radiation 5, 30 recommended dose limits 60–61 optically stimulated luminescence (OSL) dosimetry, radiation measurement 37–38 optimization, dose see dose management regulations and optimization; dose minimizing; dose optimization – ALARA optimization of radiation protection (ORP) see also dose optimization – ALARA diagnostic reference levels (DRLs) 62–64 0004429202.INDD 135 135 organizations, radiation protection 56–57 ORP see optimization of radiation protection OSL dosimetry see optically stimulated luminescence dosimetry overbeaming, computed tomography (CT) 97–98 overranging, computed tomography (CT) 97–98 patient size digital radiography (DR) 73 fluoroscopy 85–86 personnel monitoring, pregnant workers 122 personnel practices, dose management technique 10–11 photoelectric absorption (photoelectric effect), diagnostic X‐rays 23–24 physical factors, radiation protection 2–3 pitch, computed tomography (CT) 97 policies, pregnant workers 123 pregnancy 117–123 continuing/terminating 120 direct exposure 119 dose considerations 12 dose estimation 120 dose factors 119 dose reduction 121 effects of radiation 118–119 fluoroscopy 12 high‐kVp techniques and increased filtration 12 indirect exposure 119 radiation protection considerations 11–12 rationale for radiation protection 118–119 shielding 12 ultrasound 12 7/8/2019 2:09:19 PM 136 Index pregnant workers 121–123 dose limits 122 personnel monitoring 122 policies 123 privacy rights 122 protective aprons 122–123 recommended dose limits 61–62 privacy rights, pregnant workers 122 procedural factors, radiation protection 3 protective barriers see also shielding design 112–114 dose management regulations and optimization 112–114 protective aprons, pregnant workers 122–123 protective clothing, equipment specifications for fluoroscopy 108–109 protective curtains, equipment specifications for fluoroscopy 108 public exposure to radiation 5, 31 recommended dose limits 62 pulsed fluoroscopy 87 QA see quality assurance QC see quality control quality assurance (QA) dose management regulations and optimization 114–116 dose optimization – ALARA 116 goals 114 quality control (QC) acceptance criteria 115 dose management regulations and optimization 114–116 goals 114 tolerance limits 115 quantifying biologic risks see biologic risks, quantifying quantifying ionizing radiation absorbed dose 32 0004429202.INDD 136 exposure 31–32 f‐factor 33 importance 28 kinetic energy released per unit mass (KERMA) 32 linear energy transfer (LET) 33 quantities and units 31–33 quantities and units, quantifying ionizing radiation 31–33 radiation exposure sources 29–30 types 30–31 radiation measurement 36–38 film dosimetry 36–37 ionization chamber 36 Optically Stimulated Luminescence (OSL) dosimetry 37–38 thermoluminescent dosimetry (TLD) 37 wearing a personnel dosimeter 38 radiation protection actions 6, 59–60 biologic factors 3 criteria and standards 58–60 objectives 57–58 physical factors 2–3 principles 5, 58–59 procedural factors 3 scope 2–3 technical factors 3 Radiation Protection Bureau, Health Canada (RPB‐HC) 4, 57 recommended dose limits 61 radiation protection framework 4–6 dose limitation 5 dose optimization – ALARA 5 exposure types 5 justification 5 radiation protection principles 5 radiation protection organizations 56–57 radiation weighting factor, quantifying biologic risks 34 7/8/2019 2:09:19 PM Index radiobiology 39–54 radiographic antiscatter grids, digital radiography (DR) 74–75 radiographic factors affecting dose, diagnostic radiology 9 radiography see also digital radiography dose minimizing 109–110 radon, natural radiation source 29 reasons for protection in diagnostic radiology 3–4 recommended dose limits 60–62 International Commission on Radiologic Protection (ICRP) 61 members of the public 62 National Council of Radiation Protection and Measurements (NCRP) 61 occupational exposure 60–61 pregnant workers 61–62, 122 Radiation Protection Bureau, Health Canada (RPB‐HC) 61 regulations, dose see dose management regulations and optimization risks, biologic see biologic risks, quantifying RPB‐HC see Radiation Protection Bureau, Health Canada scattered radiation, fluoroscopy 87–88 scattered radiation grids digital fluoroscopy 81, 86 digital radiography (DR) 74–75 schemes for patient exposure 6–8 scope of radiation protection 2–3 shielding see also protective barriers dose management regulations and optimization 112–114 dose management technique 11 pregnancy: radiation protection considerations 12 radiation protection action 6, 59 0004429202.INDD 137 137 SID see source‐to‐image receptor distance SI units see International System of Units size‐specific dose estimate (SSDE), computed tomography (CT) 95 slice thickness, computed tomography (CT) 97 sources of radiation exposure 29–30 human origin sources 29–30 medical X‐ray exposure 30 natural radiation sources 29 nuclear medicine examinations 30 source‐to‐image receptor distance (SID) diagnostic X‐rays 19 digital radiography (DR) 73–74 equipment specifications for radiography 105 source‐to‐skin distance (SSD) equipment specifications for fluoroscopy 107 equipment specifications for radiography 106 fluoroscopy 85 spot‐film recording devices, image intensifier fluoroscopy 81 SSD see source‐to‐skin distance SSDE see size‐specific dose estimate standardized EI, exposure indicator/ index (EI) 68–69 standards and criteria, radiation protection 58–60 stochastic effects, bioeffects type 56 target material, diagnostic X‐rays 19 technical factors, radiation protection 3 television camera, image intensifier fluoroscopy 80–81 television monitor, image intensifier fluoroscopy 81 thermoluminescent dosimetry (TLD), radiation measurement 37 7/8/2019 2:09:19 PM 138 Index time, radiation protection action 6, 59 tissue weighting factor, quantifying biologic risks 35–36 TLD see thermoluminescent dosimetry tolerance limits, quality control (QC) 115 tube current, fluoroscopy 83 ultrasound, pregnancy 12 United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 57 0004429202.INDD 138 wearing a personnel dosimeter, radiation measurement 38 X‐ray control panel, equipment specifications for radiography 104 X‐ray generator, digital radiography (DR) 71–72 X‐rays see diagnostic X‐rays; medical X‐ray exposure X‐ray tube and generator digital fluoroscopy 81 image intensifier fluoroscopy 79–80 7/8/2019 2:09:20 PM