INTRODUCTION TO ANATOMY The word ‘anatome’ is Greek origin meaning cutting up (ana- up; tome – process of cutting). Anatomy is the basic medical science, which deals of the structure of human body and their relationship. Anatomy is subdivided according to the method of description into: 1) Gross (macroscopic) anatomy Regional anatomy Systemic anatomy 1 2) Microscopic anatomy ( = Histology) 3) Other subdivisions: Clinical anatomy Surgical anatomy Surface anatomy Radiological anatomy Developmental anatomy Embryology 2 Gross (macroscopic) anatomy: which deals with the body details which are seen by the naked eye. It is studied by means of dissection of the body. It is further subdivided into. a) Regional anatomy: study of a discrete portion of the body. E.g. upper limb, lower limb, thorax etc b) Systemic anatomy: study of a particular system as it is traced throughout the whole body, e.g. Reproductive system, Respiratory system…etc. Microscopic anatomy: which deals with the fine details of the body (cells and tissues). It is studied by the use of microscopic techniques - is also called Histology 3 • Other subdivisions of anatomy: Applied (Clinical) anatomy: – emphasizes aspects of body structure and function important in the practice of medicine, dentistry, and the allied health sciences. – It stresses clinical application. Surgical anatomy: – is the study of anatomy in connection with surgical operations and surgical procedures (e.g. anatomy of surgical incisions, anatomy of surgical exposures…..). 4 Surface anatomy • is the study of the surface landmarks of the underlying body points, muscles and tendons. e.g. surface anatomy of the heart, the lung or the main nerves and vessels). Radiological anatomy: • is the study of anatomy using radiological techniques e.g. X-rays, CT scan, ultrasound and MRI to demonstrate the bones or some internal organs as the heart, lungs, kidneys, stomach and intestine. 5 Body planes (coronal , sagittal, oblique, and transverse) 6 RMCP LMCP L1 L5 Four quadrants Nine regions 7 CELLS – Cells are the basic structural and functional unit of the living organism showing a variety of functional specializations which to perform all the activities necessary for the survival, growth and reproduction of the organism. – Cells are the smallest entities capable of independent life. • Activity 1: Enumerate as many human body cells as you can. Cells are diverse in – Number (around 100 trillion [1012]cells) – Type (around 250 named cell types) – Shape (round, oval, columnar, multipolar, polyhedral, cylindrical, fusiform, pyramidal, pyriform, etc.) – Size (3µm - 120µm in diameter) – Diverse functions Blood cells are examples of round cells 250 Diverse Cellular Functions Specialized Cell(s) 1. Movement Muscle & other contractile cells 2. Form adhesive and tight junctions between cells to form membranes Epithelial cells 3. Synthesize & secrete components of the Fibroblasts, cells of bone and ECM cartilage 4. Convert physical & chemical stimuli into Neurons and sensory cells action potentials 5. Synthesis & secretion of enzymes Cells of digestive glands 6. Synthesis & secretion of mucous substances Mucous-gland cells, goblet cells 7. Synthesis & secretion of steroids adrenal cortex, testis, & ovary 8. Ion transport Cells of the kidney & salivary gland ducts, stomach parietal cells 9. Intracellular digestion 10. Lipid storage 11. Metabolite absorption Macrophages & some WBC Fat cells (adipocytes) Cells lining the intestine Organization of the Cell – A typical cell, as seen by the light microscope has two major parts: the nucleus and cytoplasm. – The nucleus is separated from the cytoplasm by a nuclear membrane, and the cytoplasm is separated from the extracellular environment by a cell membrane, also called the plasma membrane. – The different substances that make up the cell are collectively called protoplasm. – Protoplasm is composed mainly of six basic substances: water, electrolytes (ions), proteins, lipids, carbohydrates, and nucleic acids. •A membrane similar to the cell membrane surrounds such important cytoplasmic organelles as nucleus, mitochondria, endoplasmic reticulum, Golgi complex, lysosomes, and peroxisomes. •Organelles that are not surrounded by membranes include ribosomes, basal bodies, centrioles, and centrosomes. . 17 Systems of the body • The 11 human systems • Integumentary • Skeletal • Muscular • Nervous • Endocrine • Circulatory • Cardiovascular • Lymphatic • Respiratory • Digestive • Urinary • Reproductive • Immune 18 1.The cardiovascular system • consists of – the heart – blood vessels The cardiovascular system • Heart – hollow, muscular, 4 chambered organ – Cardiology is a discipline of which deals with heart – Weighs about 300 g in adults (about the size of a clenched fist) – 2 cm long, 9cm wide & 6 c m thick – it rests on the diaphragm near the mid line of the thoracic cavity in the mediastinum • 2/3rd portion of the heart is located in the left side of the body, – the heart has a pointed end the apex, and a broad portion opposite to the apex called base The Heart: Surfaces 21 The Heart: Surfaces 22 Structure of the heart • Pericardium (peri = around) – is a protective and surrounding membrane of the heart – it consists of two principal portion: • the fibrous pericardium • the serous pericardium • Fibrous pericardium – is tough inelastic, dense irregular connective tissue, which looks like a bag. – It rests & attaches to the diaphragm: – its open end is fused to the vessels entering and leaving the heart. – Function of fibrous pericardium • prevents overstretching of the heart • provides protection and • anchors the heart in the mediastinum • The serous pericardium – is a thinner membrane which forms a double layer – parietal layer – • is the outer serous pericardium – visceral layer• The inner serous pericardium • adheres tightly to the surface of the heart. – pericardial fluid. • is a fluid In the cavity b/n two layers of pericardium • is important to reduce friction b/n the heart and the outer layers and also prevent the heart from external pressure. • Layers of the heart wall – contain 3 distinct layers: – Epicardium – • thin, external membrane around the heart • allow protection against friction by rubbing organs – Myocardium – • thickest layer; consists of cardiac muscle. i.e the bulk of the heart wall. • It is involuntary muscle • responsible for the ability of the heart to contract – Endocardium – • a thin innermost layer; a unique type of epithelial tissue that lines the entire circulatory system • Chambers of the heart – The heart has four chambers • two - atria (entry halls or chambers) • two ventricles (little bellies) • Right atrium – forms the right border of the heart – it receives blood from • superior vena cava • inferior vena cava and • coronary sinus – Interatrial septum- is a thin partition between right and left atriums. – blood passes from the right atrium in to the right ventricle through a valve called tricuspid valve, it consists of three leaflets of cusps • Heart Valves: – prevent back flow of blood and ensure that blood flows in the proper direction through the heat. – The valves function to maintain blood flow in one direction. – Valves open and close in response to changes in pressure: • 4 heart valves – Atrioventricular (AV) valves • tricuspid and • bicuspid valves – Semilunar valves • Aortic valve • Pulmonary valve Heart Sounds • Lub – first heart sound – occurs during ventricular systole – A-V valves closing • Dub – second heart sound – occurs during ventricular diastole – pulmonary and aortic semilunar valves closing • Murmur – abnormal heart sound Surface Anatomy of the Heart 31 • Conducting System – Sino atrial (SA) node –pacemaker – atrioventricular (AV) node – AV bundle – right and left bundle branches – Purkinje fibers Conduction System of the Heart • Two circulatory routes: –pulmonary circulation: • right ventricle ----pulmonary artery---lungs----pulmonary vein----- left atrium –systemic circulation: • left ventricle ----- aorta-----body-----superior and inferior vena cava------right atrium • Coronary circulation is part of the systemic circulation and supplies blood to the heart tissues via coronary arteries and veins. Principal Arteries of the body • aorta • ascending aorta – ascends from the heart (left ventricle) – The coronary arteries are the only branch of the ascending aorta • Aortic arch – Three vessels arise from the aortic arch: • the brachiocephalic artery–supplies the upper limbs and head regions • left common carotid artery • left subclavian artery • brachiocephlic artery – bifurcates into: • the right common carotid artery (supplies the right side of hand and neck) and the • subclavian artery (supplies the right upper limb) • The left common carotid artery and the left subclavian artery – branch directly from the aortic arch. • Arteries of the neck and head • Common carotid artery – ascends upwards in the neck lateral to trachea – Divides slightly below the angle of the mandible into • the internal carotid artery and • the external carotid artery Arteries of the upper limbs • Right subclavian- from brachiocephalic.and • left subclavian- from aortic arch. • It has the several branches in the thorax but becomes the axillary artery as it passes in the axilla. • It becomes the brachial artery in the arm. – Site for BP(blood pressere measurement) • Branches of the abdominal portion of aorta – Abdominal aorta is the segment between diaphragm and L4 – Has three main unpaired branches – Other paired branches • unpaired • Celiac trunk – – short, thick, branch, which divides into three vessels: • Splenic artery (to spleen) • Left gastric artery ( to stomach) • Common hepatic (to liver) • Superior mesenteric artery– to the small intestine (except the duodenum), cecum, appendix, transverse, and ascending colons • Inferior mesenteric artery – – last major, anterior, unpaired branch just before bifurcation into the common iliac arteries. • Supplies the descending, and sigmoid colons, rectum • Paired branches – Renal artery– to kidney – Suprarenal artery - to adrenal glands – Testicular artery - to testes – ovarian artery- to ovaries • Arteries of the pelvis and lower limbs –the abdominal aorta terminates by bifurcating into • right common iliac arteries • left common iliac arteries –The common iliac divides into • the internal iliac and • external iliac artery • The external iliac artery– – passes out of pelvis beneath the inguinal ligament to become the femoral artery • Femoral artery – – passes through the femoral triangle on the upper medial portion of the thigh. – At this point it is close to the surface, hence for pulpation and pressure. – the femoral artery becomes the popliteal artery as it passes across the posterior aspect of the knee. Venous drainage of the body • Veins Draining the neck and head • External jugular vein – from scalp, portions of face, superficial neck region – drain into right and left subclavian vein. • Internal jugular vein – from brain, meniges, deep regions of face and neck – larger and deeper than the external jugular vein – passes in carotid sheath with the common carotid and vagus nerve beneath sternocleidomastoid muscle • subclavian vein and internal jugular unite to form the brachiocephalic vein • the two brachiocephalic veins merge to form the superior vena cava, w/h empties into the right atrium Veins of the upper extremity • Consists of superficial and deep venous drainage • Deep veins • accompany the arteries and bear their names / region – radial vein + ulnar vein • both drain from deep and superficial palmar arches • radial and ulnar veins join in the cubital fossa to form the brachial vein, which continues up on the medial side of the arm. – Brachial vein -axiliary → subclavian → internal jugular → brachiocephalic superficial veins • are the basilic and – cephalic veins • basilic vein – drains blood from ulnar side of forearm, medial side of arm – merges with brachial vein near the head of the humerus to form the axillary vein • cephalic vein – drains superficial region of hand and forearm on radial side – joins axillary vein in the shoulder region – median cubital vein ascends from the cephalic vein to join basilic vein on radial side. It is a site of venipuncture • Veins of the thorax • Superior vena cava – receives blood from the right and left brachiocephalic veins, which drain head, neck, and upper limb as well as from azygous veins. – lacks valves which are characteristics of most veins • The azygous vein – extends superiorly along the dorsal abdominal and thoracic walls on the right side of the vertebral column • The superficial vein include –small saphenous vein : • arises from the lateral side of the foot, courses posteriorly along the surface of the calf of the leg and enters deep into the popliteal vein behind the knee. –Great saphenous vein : • longest vessel in the body, originates at the arch of the foot and ascends superiorly along the medial aspect of the leg and thigh before draining into the femoral vein. THE DIGESTIVE SYSTEM Introduction • The organs of the digestive system are specialized for the digestion and absorption of food. • Anatomically and functionally, the digestive system can be divided into: – a tubular digestive tract, or (GI tract) – accessory organs. • The GI tract – is approximately 9m long and – extends from the mouth to the anus. – It include • oral cavity -stomach • pharynx -small intestine, • esophagus -large intestine. • Accessory digestive organs – it include • the teeth • tongues • salivary glands -liver - gallbladder - pancreas. • Palate:– the roof of the oral cavity and consists of the bony • soft palate– the mobile fibromuscular part (posterior 2/3 rd) – attached to the posterior edge of the hard palate. • hard palate – anterior 2/3 rd and – is formed by the palatine process of maxilla and the horizontal plate of palatine bone. • The uvula – – is a conical process (cone-shaped projection) suspended from the middle inferior border of the soft palate. – The soft palate and uvula are drawn upward against the wall of the pharynx, – thereby closing the nasophaynx and preventing food and fluid from entering the nasal cavity (regurgitation). Abdominal visceral organs 68 Histological Layers of the GIT • Esophagus – This is a collapsible muscular tube (25cm) that connects the pharynx to the stomach, and located posterior to the trachea. – It passes through the diaphragm is an opening called esophageal hiatus. – The esophagus is lined with a nonkeratinzed stratified squamous epithelium. – The upper third of the esophagus contains skeletal muscle, the middle third contains both skeletal and smooth muscle, and the terminal portion contains only smooth muscle. – The lumen of the terminal portion of the esophagus is slightly narrowed due to the presence of the lower esophageal (gastroesophageal) sphincter. – This prevents regurgitation of stomach contents into the esophagus. • Stomach –The stomach is a J-shaped pouch and is the most distensible part of the GIT. –The functions of the stomach are: • to store food as it is mechanically churned with gastric secretions • to initiate the digestion of proteins • to carry out limited absorption • to move food into the small intestine as a chyme (pasty material) • Secration of gastric juice The stomach is divided into four regions – Cardiac: - the narrow upper region immediately below the gastroesophangeal sphincter – Fundus: - the dome shaped portion to the left and in direct contact with diaphragm – Body: - the lager central portion – Pylorus:- the funnel shaped terminal portion. • Small intestine • It is the portion of the GIT b/n the pyloric sphincter of the stomach and the ileocecal valve opening into the large intestine. – is the site where digestion is completed and nutrients are absorbed. – The surface area of the intestinal wall is increased by villi, and microvilli. • The functions the small intestine are – the reception of the secretions from the liver and pancreas, – mechanical breakdown of chime, – absorption of nutrients and – transportation of the remaining undigested material to the large intestine. • The small intestine is divided into three regions • These are – the duodenum, – jejunum and – ileum. Small intestine Small Intestine: • longest part of the GIT & extends from pyloric orifice of stomach to ileocecal fold. • is about 6-7 m long with a narrowing diameter from beginning to end • Major digestive organ • Primary site for absorption • consists of duodenum (25 cm), jejunum (2.5 m) & ileum (3.6 m). • first part of small intestine is duodenum. 75 Jejunum and Ileum • Jejunum begins at duodeno-jejunal flexure • Has intraperitoneal course. • Ileum ends at ileocecal junction. • Most jejunum lies in LUQ • while most ileum lies in RLQ. • Small coils of small 76 Jejunum & Ileum Jejunum: • is about 2.5m long & represents proximal two-fifths. • It is mostly in the left upper quadrant of the abdomen • It is larger in diameter and has a thicker wall than the ileum. • less prominent arterial arcades & longer vasa recta (straight arteries), compared to those of ileum, are a unique characteristic of jejunum . Jejunum Ileum 77 Jejunum & Ileum Ileum: • is about 4m long & makes up distal three-fifths of Small Intestine • is mostly in right lower quadrant. • Compared to jejunum, ileum has thinner walls, shorter vasa recta, more arterial arcades & more mesenteric fat • ileum opens into large intestine 78 Distinguishing Characteristics of Jejunum and Ileum in Living Persons(summary) Characteristics Jejunum Ileum •Caliber 2 - 4 cm 2 - 3 cm •Wall Thick & heavy Thin & light •Vascularity Greater Less •Vasa recta Long Short •Arcades A few large loops Many short loops •Fat in mesentery Less More •Lymphoid nodules (Peyer patches) •Color Few Many Red Pale 79 • The large intestine is structurally divided into – the cecum – colon – rectum – anal canal. • The cecum – is the dilated pouch that hangs inferiorly slightly below the ileocecal valve. – The ileocecal valve is a fold of mucus membrane at the junction of the small and large intestine that prohibits the back flow of chyme. – The appendix (9cm) is attached to the inferior medial margin of the cecum. – It has an abundance of lymphatic tissue which serves to resist infection. The large intestine • The colon – consists of ascending, transverse, descending, and sigmoid portions. – The ascending colon extends superiorly from the cecum along the right abdominal wall to the interior surface of the liver. – Hence the colon bends sharply to the left at the hepatic flexure (right colic flexure) and transversely crosses the upper abdominal cavity as the transverse colon. – At the left abdominal wall, it bends at a right angel called the splenic flexure (or left colic flexure). – The latter marks the beginning of the descending colon. – This passes inferiorly along the left abdominal wall to the pelvic region where it bends medially from the pelvic brim to form an S- shaped curve called the sigmoid colon.. • The terminal (20cm) portion of the GIT is the rectum of which the last 2 to 3 cm is called the anal canal. • The anus is the external opening of the anal canal. • Two sphincter muscles guard the anal opening: – the internal anal – external anal sphincter • composed of smooth muscle fibers and the composed of skeletal muscle. • The mucus membrane of the anal canal is a ranged into highly vascular longitudinal folds called anal columns Accessory digestive glands – These organs aid in the chemical break down of food. – These are • the liver • gallbladder, and • pancreas. – The liver and pancreas function as exocrine glands in this process because their secretions are transported to the lumen of the GIT via ducts. The Liver • Liver is the largest gland in the body It normally weighs about 1.5kg. • accounts for about one-fortieth of the body weight in the adult. • At birth, it represents one-twentieth of weight of the body • In the adult, it is concealed under the costal margin and cannot be felt or palpated. • The Liver lies principally in the right hypochondrium & epigastrium & extends into left hypochondrium. RUQ 86 Surface anatomy of liver • Liver has two surfaces:– diaphragmatic & visceral surfaces which are separated by an irregular, inferior border. • Diaphragmatic surface : • is smooth & is related to the diaphragm. 87 Ligaments of liver • On the diaphragmatic surface – Coronary ligament –bare area – Falciform ligament – right and left lobe On the visceral surface • Round ligaments of liver(ligamentum teres) • Ligamentum venous 88 – The porta of the liver is where the hepatic artery, portal vein, lymphatic, and nerves enter the liver and where the hepatic ducts exit. • The liver carries out numerous functions: – synthesis, storage, and release of vitamins; – synthesis, storage, and release of glycogen; – synthesis of blood proteins; – phagocytosis of old red blood cells and certain bacteria; – removal of toxic substances; and – production of bile. • Gall bladder – is a sack like organ attached to the inferior surface of the liver. – It stores and concentrates bile, which drains to it from the liver by way of the bile ducts, hepatic duct, and cystic duct, respectively. – Bile is a yellowish-green fluid containing – bile salts bilirubin (a product resulting from a breakdown of blood), cholesterol and other compounds. – Bile is continuously produced by the liver and drains through the hepatic and common bile ducts to the duodenum for the emulsification and absorption of fats. – When the small intestine is empty of food, the sphincter of ampulla (Oddi) constricts and bile is • Pancreas – The pancreas (12.5cm long and 2.5cm thick) – is a soft, lobulated, glandular organ that has both exocrine and endocrine function. – The endocrine function is performed by clusters of cells called the pancreatic islets (islets of langerhans) that secrete the hormones insulin and glucagons into the blood. – The pancreas, as an exocrine gland, also secretes pancreatic juice through the pancreatic duct into the duodenum. – It is positioned along the posterior abdominal wall, adjacent to the greater curvature of the stomach. – It has an expanded head near the duodenum, a centrally located body, and a tapering tail near the spleen. Respiratory System Functions 1. Provides extensive gas exchange surface area between air and circulating blood 2. Moves air to and from exchange surfaces of lungs 3. Protects respiratory surfaces from outside environment 4. Produces sounds-speaking, singing 5. Participates in olfactory sense The Respiratory Tract • Consists of a conducting portion: – from nasal cavity to terminal bronchioles • Consists of a respiratory portion: – the respiratory bronchioles and alveoli - Are air-filled pockets within the lungs • where all gas exchange takes place The Trachea & Bronchial Tree 95 Anatomy of the Larynx Figure 23–4 Cartilages of the Larynx • 3 large, unpaired cartilages form the larynx: – the thyroid cartilage – the cricoid cartilage – the epiglottis The Thyroid Cartilage • Also called the Adam’s apple • Is a hyaline cartilage • Forms anterior and lateral walls of larynx • Ligaments attach to hyoid bone, epiglottis, and laryngeal cartilages The Cricoid Cartilage • Is a hyaline cartilage • Form posterior portion of larynx • Ligaments attach to first tracheal cartilage • Articulates with arytenoid cartilages The Epiglottis • Composed of elastic cartilage • Ligaments attach to thyroid cartilage and hyoid bone Cartilage Functions • Prevents entry of food and liquids into respiratory tract – During swallowing: – the larynx is elevated – the epiglottis folds back over glottis • Thyroid and cricoid cartilages support and protect: – the glottis – the entrance to trachea The Glottis Figure 23–5 Sound Production • Air passing through glottis: – vibrates vocal folds – produces sound waves Sound Variation • Sound is varied by: – tension on vocal folds The Trachea • Also called the windpipe • Extends from the cricoid cartilage into mediastinum – where it branches into right and left pulmonary bronchi The Tracheal Cartilages • 15–20 tracheal cartilages: – strengthen and protect airway – discontinuous where trachea contacts esophagus • Ends of each tracheal cartilage are connected by: – an elastic ligament and trachealis muscle The Primary Bronchi • Right and left primary bronchi: – separated by an internal ridge (the carina) The Right Primary Bronchus • Is larger in diameter than the left • Descends at a steeper angle Structure of Primary Bronchi • Each primary bronchus: – travels to a groove (hilus) along medial surface of the lung Hilus • Where pulmonary nerves, blood vessels, and lymphatics enter lung • Anchored in meshwork of connective tissue The Lungs • Left and right lungs: – are in left and right pleural cavities • The base: – inferior portion of each lung rests on superior surface of diaphragm Root of the Right Lung Right lung: is wider is displaced upward by liver 109 Root of the Left Lung • Left lung: – is longer – is displaced leftward by the heart forming the cardiac notch 110 Secondary Bronchi • Branch to form tertiary bronchi, also called the segmental bronchi • Each segmental bronchus: – supplies air to a single bronchopulmonary segment An Alveolus • Has an extensive network of capillaries • Is surrounded by elastic fibers Alveolar Epithelium • Consists of simple squamous epithelium • Patrolled by alveolar macrophages, also called dust cells • Contains septal cells (Type II cells) that produce surfactant Surfactant • Is an oily secretion • Contains phospholipids and proteins • Coats alveolar surfaces and reduces surface tension • Tracheotomy – an operation to make an opening into trachea • Intubation – a tube is inserted into the mouth or nose and passed inferiorly through larynx and trachea to maintain an open airway or to serve as a conduit through which to administer certain drugs Urinary system – consists of: – Two kidneys – Two ureters – The urinary bladder & – The urethra – Responsible for water & electrolytes homeostasis: by eliminating excess water & electrolytes from the body Functions of urinary system – The maintenance of water and electrolyte balance – Excretion of many toxic metabolic waste products – The end product of urinary system is urine kidneys ureters urinary bladder urethra outside of the body – In female – urethra is solely a urinary duct – In male – it also serves as the pathway for ejaculation of the semen in addition to urine – Two Kidneys – Perform all functions except actual excretion. – Two Ureters – Convey urine from Kidneys to Urinary Bladder – Urinary Bladder – Holds Urine until excretion/void – Urethra – Conveys urine from bladder to outside of body (discharge) The kidneys – are a pair of reddish brown, bean shaped organs Position – – – – – – in the posterior wall of the abdominal region. lie on either side of the vertebral column, below the diaphragm and liver, are retroperitoneal the right is slightly lower than the left due to liver capped by the adrenal gland CT coverings – Pararenal fat – Renal fascia: binds to abdominal wall – Adipose capsule: cushions kidney Covering of kidney are: – Pararenal fat tissue of the posterior abdominal wall – Renal fascia: dense fibrous CT anchors kidneys/or adrenal gland to the surroundings fat tissues or thin layer of dense irregular connective tissue that anchors the kidney to the abdominal wall. – Adipose capsule: is a mass of a perirenal fatty tissue surrounding the renal capsule. – Renal capsule: closely related to the kidney cortical surface – It serves as a barrier against trauma and helps maintain the shape of the kidney Renal capsule Microscopic Structure of the kidney The nephron – is the functional unit of the kidney – consists of the blood processing unit which serves to produce urine – to produce urine, nephrons and collecting tubules and ducts perform three basic processes: glomerular filtration, tubular reabsorption, and tubular secretion – there are more than a million nephrons per kidney – consists of a renal corpuscle and tubules, and small blood vessels. • Renal blood vessels • Arterial blood enters the kidney through the renal artery → Segmental arteries→ interlobar arteries→ the arcuate arteries→ interlobular → afferent arterioles. • deliver blood into glomeruli capillary • efferent arterioles → peritubular capillaries →inter lobular veins→ arcuate veins →interlobar veins → renal veins→ inferior vena cava. URETER – Cylindrical tube, 3- 4 mm in diameter, 25-30 cm in length Urethra – a single tubular structure that conveys urine from urinary bladder to outside. – communicates the urinary bladder with the outside – its wall contains mucus secreting urethral glands – consists of two muscular sphincters: – Internal urethral sphincter – External urethral sphincter – Male urethra is longer than female urethra and also functions as a route for semen Female Urethra – relatively short. – about 4cm long and 5-6 mm in diameter – empties urine through urethral orifice into the vestibule b/n the labia minora. – positioned immediately anterior to the vaginal orifice, and 2.5cm posterior to the root of clitoris The Male Urethra – is about 18-20 cm long. serves both as urinary and reproductive systems – conveys urine from urinary bladder and an exit for semen – S-shaped because of the shape of penis – Four parts: 1. The Prostatic Part (3-4 cm )- during orgasm receives semen 2. The Membranous Part (1-2 cm) - passes through pelvic diaphragm 3. The spongy (penile) part – within the penis (penile) 4. Fossa Navicularis part: in the glans penis – opens to exterior Kidney stones – A hard granule of calcium, phosphate, uric acid and protein. – Form in renal pelvis and get lodged in pelvis or ureter. – Caused by urinary tract infections, dehydration, pH imbalances, or an enlarged prostate gland. – Treated with stone dissolving drugs, surgical removal, or lithotripsy (ultrasonic vibrations) Reproductive system 132 INTRODUCTION • Sexual reproduction involves production of offsprings with a genetic makeup inherited from parents. • Function of male reproductive system: – to produce the male gamete, or spermatozoa, – to transfer it to the female through coitus. • Function of female reproductive system: – to produce female gamete, or ova – receive the sperm from the male during coitus. – a site for • fertilization, • implantation, development of the embryo, – facilitate delivery of the baby during parturition. – Provides a means of nourishing the baby through secretions 133 from mammary glands after birth. • The reproductive system is a unique body system in three respects: – To perpetuate the species by passing genetic material from generation to generation [other body systems function to sustain the individual) – The anatomy and physiology of the reproductive organs constitute the major d/c b/n the male and female species (other systems have minor gender differences) – It undergoes latent development under hormonal control (others function at birth but the reproductive system does not until puberty). 134 • THE MALE REPRODUCTIVE ANATOMY – can be categorized on functional basis as follows: • Primary sex organs (= gonads = testes in scrotum) • Secondary sex organs – transporting ducts; • Epididymides • ductus deferens • ejaculatory ducts • urethra. – accessory glands • seminal vessicle • prostate • bulbourethral glands. – compulatory organ • penis (contains erectile tissue). 135 136 137 • The Ductus Deferens • also known as vas deferens • is a thick-walled muscular tube • begins in the tail of the epididymis and • ends by joining the duct of the seminal vesicle to form the ejaculatory duct. • It is about 45 cm long and ascends in the spermatic cord. • in its course no other structure intervenes b/n it and the peritoneum. 138 139 140 • The Ejaculatory Ducts – formed by the union of the ducts of the seminal vesicle and ductus deferens. – are about 2.5 cm long – They run anteroinferiorly through the posterior part of the prostate along the sides of the prostatic utricle. – open in to the posterior wall of the prostatic urethra. 141 • The seminal vesicles – is a thin-walled, Blind-ending tube about 5 cm long; – located b/n the fundus of the bladder and the rectum. – do not store sperm cells. – Provide most of the volume of the semen (a thick yellowish alkaline fluid) 142 143 • The prostate gland – Largest accessory gland of the male repr. system – Partly glandular & partly fibromucular – Surrounds the prostatic urethra. • The prostate has – base – apex – 4 surfaces • posterior • anterior • 2 inferolateral surfaces – 4 lobes • Anterior lobe • Posterior lobe • Middle lobe • Lateral lobes 144 • Bulbourethral Glands – are two pea-size glands (Cowper glands). – lie posterolateral to the intermediate part of the urethra, – largely embedded within the external urethral sphincter – The ducts of the bulbourethral glands open into the proximal part of the spongy urethra in the bulb of the penis. – Their mucus-like secretion enters the urethra during sexual arousal. 145 146 147 • Distal structures of the body, • Glans penis(head) – is distal expansion of the corpus spongiosum of the penis – Is cone shape – Contain higher concentration of sensory nerves – Sensitive to physical stimuli – has : • Corona – margin of the glans projects beyond the ends of the corpora cavernosa • The corona overhangs the neck of the glans 148 THE FEMALE REPRODUCTIVE ANATOMY – Include:• the Vagina • Uterus • Uterine tubes • Ovaries 149 • VAGINA – a musculomembranous(7-9cms) tube – extends from the cervix to the vestibule – Its posterior wall is ~1cm longer than the anterior – Serves: • as a canal for menstrual fluid. • Forms birth canal. • sexual intercourse. – The vagina is usually collapsed except at its superior end, where the cervix holds them apart. – 4 muscles compress the vagina and act like sphincters: – pubovaginalis – external urethral sphincter – urethrovaginal sphincter – bulbospongiosus 150 • UTERUS – The uterus (womb) is a thick-walled, pearshaped, hollow muscular organ. – The non-gravid uterus lies in the lesser pelvis, – The normal adult uterus position is anteverted. and anteflexed (flexed or bent anteriorly) so that its mass lies over the bladder. 151 152 B)abnormal positions 153 Cervix • cylindrical, lower part of uterus whose inferior part projects into vagina; – the cavity of the cervix (cervical canal) communicates with uterine cavity & vagina through its internal os & external os respectively. – pierces ant. wall of vagina divided into supravaginal & vaginal parts – paras cx is d/t from that of non para. 154 155 The wall of the uterus • 3 layers: • Perimetrium: – the outer serous coat – Made up of peritoneum. • Myometrium: – the middle muscular coat of smooth muscle – greatly distended during pregnancy – blood vessels and nerves of the uterus are located in this coat. • Endometrium: – the inner mucous coat, which firmly adheres to the myometrium – is actively involved in the menstrual cycle – differ in structure with each stage – site of implantation – if no conception it shed as menstrual 156 • Supports of the Uterus • normal positions of uterus is maintained by • ligaments • muscles • fibromuscular structures • peritoneal folds • Ligaments of the Uterus – Broad ligament – Round ligament – Cardinal (transverse cervical) ligament – Uterosacral ligament 157 • The Uterine Tubes – These are 10 cm long and 1 cm in diameter. – They extend laterally from the cornua of the uterus. – Each tube opens to horn of the uterus proximaly – opens into the peritoneal cavity near the ovary at its distal end • Function: – carry oocytes from the ovaries to the fertilisation site& – sperm from Ux. to fertilisation site – conveys the dividing zygote to the uterine cavity. Serve as fertilisation site – The uterine tube has 4 parts: – infundibulum – ampulla – isthmus – Intramural 158 • The infundibulum – is the funnel-shaped distal end – opens into the peritoneal cavity. – has finger-like processes called the fimbriae • The ampulla – begins at the medial end of the infundibulum. – the widest & longest part, – is site of fertilization • The isthmus – b/n ampulla & intramural part – narrow part • Intramural part – is the short segment that opens into the uterine cavity at the uterine horn. 159 Ectopic pregnacy Sites Ampulla (95%) Isthmus (8%) Cornua (< 2%) Ovary (< 2%) Abdomen (< 2%) Cervix (< 2%) 160 • Tubal Ligation – Ligation of the uterine tubes is a surgical method of birth control. – performed through a short suprapubic incision made just at the pubic hairline. 161 OVARY • Position – located in the ovarian fossa – Lies close to appendix on the right – Bounded anteriorly by medial umbilical ligament – Its anterior border is attached to post border of broad ligament by mesovarium – Attached to uterus by the ligament of ovary which runs in the mesovarium of the broad ligament – not covered by peritoneum-- oocyte is released into peritoneal cavity during ovulation • Has two parts – Cortex 162 163 Female External Genitalia(vulva) • include – mons pubis – labia majora –labia minora – clitoris – bulbs of the vestibule –greater and lesser vestibular glands. – hymen 164 vulva 165 • Mons Pubis (L. mountain) – is a rounded fatty elevation anterior to the pubic symphysis. – The amount of fat increases during puberty and decreases after menopause. – covered with coarse pubic hairs during puberty, which also decrease after menopause. – The typical female distribution of pubic hair has a horizontal superior limit across the pubic region 166 167 • The Labia Majora (L. large lips) – are two symmetrical folds of fat & skin – provide protection for the urethral and vaginal orifices – The labia majora meet anteriorly at the anterior labial commissure. – They do not join posteriorly but a transverse bridge of skin called the posterior labial commissure passes between them. The Labia Minora (L. small lips) – are thin, delicate folds of fat-free hairless skin. – They are located between the labia majora. – It contains many sensory nerve endings. – Sebaceous and sweat glands open on both of their surfaces. – The labia minora enclose the vestibule of the vagina – They meet just superior to the clitoris to form a fold of skin called the prepuce (clitoral hood). – In young females the labia minora are usually united posteriorly by a small fold of the skin, the frenulum of the labia minora. 168 • The Vestibule of the Vagina – is the space b/n the labia minora. – The urethra, vagina, and ducts of the greater vestibular glands open into the vestibule. • The External Urethral Orifice – located 2 to 3 cm posterior to the clitoris and – immediately anterior to the vaginal orifice. – the paraurethral glands (Skene's glands) ducts open On each side of this orifice – These glands are homologous to the prostate in the male. • The Vaginal Orifice – inferior and posterior to the much smaller external urethral orifice. – The size and appearance of the vaginal orifice varies with the condition of the hymen 169 vestibular glands • The Greater Vestibular Glands(B.G ) – located on each side of the vestibule of the vagina, – posterolateral to the vaginal orifice. – ducts open into the vestibule of the vagina on each side of the vaginal orifice. – secrete a small amount of lubricating mucus into the vestibule of the vagina during sexual arousal. – homologous with the bulbourethral glands in the male. The Lesser Vestibular Glands – are small glands on each side of the vestibule of the vagina. – They open into it b/n the urethral and vaginal orifices. – also secrete mucus into the vestibule, w/c moistens 170 the labia and the vestibule. The Clitoris • is an erectile organ 2 to 3 cm in length. • It is homologous with the penis and. • Unlike the penis, is not traversed by the urethra;therefore it has no corpus spongiosum. • It is usually hidden by the labia when it is flaccid. • It is suspended by a suspensory ligament. • enlarge upon tactile stimulation, like the penis • but it does not lengthen significantly. • It is highly sensitive and very important in the sexual arousal of a female. 171 • The clitoris consists of • a root and • a body that are composed of – two crura, – two corpora cavernosa, – a glans • the prepuce of the clitoris – formed from The parts of the labia minora passing anterior to the clitoris – homologous with the male prepuce. • frenulum of the clitoris – formed from the parts of the labia passing posterior to the clitoris – is homologous with the frenulum of the penile prepuce. 172 173 174 HYMEN • the ancient Greek god of marriage. • A thin fold of mucous membrane that covers all or part of the entrance to the vagina 175 D/t SHAPES OF HYMEN Annular hymen Cribriform hymen Crescentic hymen Experianced hymen Parous hymen Imperforated hymen 176 Skeletal system(Osteology) • The skeletal system includes all the bones in the body, the ligaments and the cartilages associated with the bone • The adult human has 206 bones(80+126) • Provides the framework for the body • Protects and supports body organs • Site of blood cell formation • Stores minerals • Allows for body movement 177 Bone Tissue • Two Kinds: • Compact bone tissue- the bone’s shaft and the outer portion of its two ends. – Compact bone forms in thin, circular layers with small canals at their centers, which contain blood vessels and nerves. – Cells communicate with each other through the canals. • Spongy bone tissue- inside the shaft of long bones. 178 • Much of it is composed of a cylinder of dense white osseous tissue called compact bone. - it inclose a medulary cavity/marrow cavity which contain a bone marrow. • At the end of a bone, a central space is occupied by a more loosely organized tissue ,spongy bone. • Principal parts of long bone has: - a shaft/diphysis- the middle region - epiphysis- located at the two ends Where one bone meets another is covered by a hyaline cartilage Articular cartilage 179 Spongy bone tissue Central canal compact bone tissue spongy bone tissue compact bone outer layer of dense 180 connective tissue • 3.2 Shapes of bones • classified into four principal types. – Long bones: • are longer than wide • function as levers. • E.g most of the bones of the upper and lower limbs. – Short bones: • cube-shaped and are found in confined spaces where they transfer forces. • E.g.wrist and ankle bones. – Flat bones: • have broad, dense surface for muscle attachment or protection of underlying organs. • E.g. the cranium, ribs, and bones of the shoulder 181 girdle. • Irregular bones: – have varied shapes and have many surface markings for muscle attachment. – E.g.the facial bones and vertebrae. • Sesamoid bones: – round or oval nodules that develop in certain tendons – e.g. the patella. – found commonly where tendons cross the ends of long bones in the limbs • Accessory bones: – develop when additional ossification centers appear and give rise to extra bones. – E.g sutural (wormian) bones of the skull and 182 accessory bones of the foot. Divisions of the skeletal system. • consists of 206 bones in the adult • It is divided into – the axial – the appendicular portions • THE AXIAL SKELETON – consists of the bones that form the axis of the body – Form skeleton of the head, neck and trunk. • Skull – the cranial bones – the facial bones • Auditory ossicles – malleus – incus – stapes 183 • Hyoid bone - located above the larynx and below the • Vertebral column or back bone – 5 group of bones(C7,T12,L5,S1,C1) • Rib cage or thoracic cage – 12 ribs – the sternum. – T12 184 • The appendicular skeleton –Pectoral girdle – scapulae – clavicles. –the upper limb –the pelvic girdles. –lower limb 185 •Upper limbs – consist of • humerus • ulna • radius • carpal • metacarpal • phalanges 186 Pelvic girdle formed by – two hipbones – sacrum of the – coccyx Lower limbs • Contain – femur – patella. – tibia – fibula – tarsal – metatarsal – phalanges 189 • The Axial Skeleton • A. The Skull –consists of cranial bones and facial bones. –The cranial bones • 8 in number. – The facial bones • 14 in number. 190 191 The Adult Skull – lateral view 192 • Facial Bones – with certain cranial bones (frontal and portions of the ethmoid and temporal bones) provide the basic shape of the face. – support the teeth and provide attachments for various muscles that move the jaw and cause facial expressions. – All are paired except the vomer and mandible. – Maxillae form upper jaw. – Mandible or lower jaw is the only moveable bone of the skull. – It is attached to the skull by the temporomandibular joint. – Other bones of the face include the palatine bones, zygomatic bones, lacrimal bones, nasal bones, 193 vomer, and inferior nasal conchae 194 • B. The vertebral column – composed of 33 individual vertebrae; –7 cervical, –12 thoracic, –5 lumbar, –5 fused sacral and –4 or 5 fused coccygeal vertebrae, – of which 26 are moveable and the rest are fused. 195 196 C. Rib Cage • This consists of the – thoracic vertebrae, – 12 paired ribs, costal cartilages and – the sternum. • It supports the pectoral girdle and upper limbs, protects and supports the thoracic and upper abdominal viscera, and plays a major role in breathing. 197 • Ribs – There are 12 pairs, each pair being attached posteriorly to a thoracic vertebra. – Anteriorly, the 1st seven pairs are anchored to the sternum by individual costal cartilages and are called true ribs. – The remaining five pairs (8,9,10,11 and 12) are termed false ribs – The last two pairs of false ribs (11 and 12) do not attach at all to the sternum, and are called floating ribs. • Each of the first ten ribs has a head and a tubercle for articulation with a vertebra. • The last two have a head but no tubercle. – Each of the 12 pairs (all) has a neck, angle and a 198 body 199 200 201 • The pelvis is divided into two: – a pelvis major (false pelvis) –and a pelvis minor (true pelvis or obstetric pelvis) by the pelvic brim. –the pelvic brim • gives the anteroposterior (AP) diameter of the superior pelvic aperture or pelvic inlet. 202 203 • There are structural differences between the pelvis of an adult male and that of an adult female which reflect the female’s role in pregnancy and parturition. 204 • F. Thigh • Femur (thigh bone): – This is the only bone of the thigh. – It’s the longest, heaviest, strongest bone in the body. – Parts – The proximal end • rounded head articulates with the acetabulum • The neck • greater trochanter, • lesser trochanter. – The shaft (body) 205 • Patella (kneecap) –a triangular sesamoid bone. –articulate with the medial and lateral condyles of the femur –The patella protects the knee joints – strengthens the quadriceps tendon. –It also increases the leverage of the quadriceps femoris muscle as it extends the knee joints. 206 Leg • Tibia (Shinbone) • articulates proximally with the femur at the knee joint to bear the weight of the body & distally with the talus of the ankle. • parts • Proximaly – medial and lateral condyles – intercondylar eminence. – Between the condyles is the – The tibial tuberosity. – fibular notch. – lateral and medial epicondyles. • Distal end – The medial malleolus 207 208 • Tarsus: – consists of seven tarsal bones. – The talus articulates with the tibia and fibula to form the ankle joint. – The calcaneus is the largest of the tarsal bones and provides skeletal support for the heel of the foot. . – The navicular bone lies anterior to the talus. – The remaining four tarsal bones form a distal series that articulate with the metatarsal bones. – These are, from medial to lateral side, the medial cuneiform, intermediate cuneiform, and lateral cuneiform bones, and the cuboid bone. 209 210 • 3.4 Articulations/Joints The skeletal system is able to permit body movement a The science concerned with the study of joints is called arthrology. • classified according to structure or function. • Structurally 3 types (i.e., based on presence or absence of joint cavity). – Fibrous joint – Cartilagenous joints – Synovial joints • Functionally 3 types of joints (i.e. based on the degree of movement) – Synarthroses –immovable joints – Amphiarthroses – slightly movable – Diarthroses – freely movable 211 • Fibrous Joints – lacks a joint cavity – articulating bones JOIN by a fibrous connective tissue. – are rigid and relatively immovable. – 3 types: sutures, syndesmoses and gomphoses • Sutures: – Found only b/n the flat bones of the skull – characterized by a thin layer of dense regular connective tissue that binds the articulating bones. – They form at 18months of age and replace the pliable fontanels of an infant’s skull. • Syndesmosis: – Found only in forearm) and leg where adjacent bones – E.g., tibiofibular joint, and radioulnar joint 212 • Gomphosis: • Cartilagenous joints – lack a joint cavity – articulating bones binds by cartilage. – They allow limited movement in response to twisting, compression or stress. – The two types of cartilagenous joints are symphyses and synchondroses. – Symphyses: • the adjoining bones are separated by a pad of fibrocartilage. • This pad cushions the joint and allows limited movement. E.g., symphysis pubis 213 and intervetebral discs. • Synchondroses: – Have hyaline cartilage b/n the bone segments. – articulations b/n the ribs and the sternum. Some temporary joints of these sorts exist between the epiphyses and diaphyses of long bones forming epiphyseal plates (growth lines) in children. • Synovial joints – These joints are the most common and – make up most of the joints of the skeletal system. – Hence, they provide free movement in most parts of the body (diarthrotic). 214 49 215 • Based on the type of movements they permit and the shapes of the articular surfaces, they are classified as – gliding – hinge – pivot – condyloid – saddle or – ball-and socket joints 216 • Plane/ Gliding: –Allows only side-to-side and back-andforth movements with some slight rotation. –The articulating surface can be nearly flat or one may be slightly concave and the other slightly convex. – E.g., Intercarpal and intertarsal joints, sternoclavicular joint and the joint between the articular processes of adjacent vertebrae. 217 Fig 3.4 A. Plane joint; B. Saddle joint; C. Condyloid/ellipsoidal joint Sliding joint 218 • Condyloid: – An oval, convex articular surface fits into an elliptical, concave depression – This permits angular movement in two directions (biaxial) such as up-and-down and side-to-side motion. –E.g., atlanto-ocipital and radiocarpal joints. 219 220 • Saddle: – A saddle-shaped joint whose articular process, each of which, has a concave surface in one direction and a convex surface in another – It’s a modified condyloid joint that allows a wide range of movement. – E.g., joint at the thumb between the trapezium of the carpus and the first metacarpal bone 221 • Hinge: – Allows bending in only one plane like a hinge of a door. – The surface of one of the articulating bones is always concave and the other, convex. – E.g., knee, humeroulnar (elbow), interphalange joints. 222 Hinge joint 223 • Pivot: • Permits rotation about a central axis in which a conical or rounded surface fits into a depression. • E.g., atlantoaxial and radioulnar joints. 224 225 • Ball-and-socket: – Formed by the articulation of a rounded convex surface with a cuplike cavity . – This provides the greatest range of movement of all synovial joints. – E.g., hip and shoulder joints 226 Ball & Socket joint 227 Muscular system(Myology ) • Composed of muscles and tendons • Muscles which make up 40–50% of total adult body weight. • Consists of over 600-700 individual skeletal muscles • Produces body movement • Heat production (maintain Temp.) • Maintains posture • Control the openings (sphincters) • • • • Three type of muscle tissue Skeletal muscle Cardiac muscle Smooth muscle 228 • 4.1 Types of muscles • Muscle is classified into 3 categories according to morphology and physiological function: • Depends on the presence or absence of cross striations, location and functions. • 1) Skeletal (Striated) = striated (striped in appearance under microscope), voluntary (under conscious control) • 2) Cardiac = striated, involuntary • 3) Smooth = non-striated, involuntary 229 Skeletal Muscle Tissue 230 • Muscle shapes • Flat muscles – have parallel fibers – e.g., external oblique. • Pinnate muscles – feather-like (L. pennatus, feather) – may be unipennate, bipennate, or multipennat – e.g., extensor digitorum longus (unipennate), bellies of the gastrocnemius (bipennate), and deltoid (multi-pennate). 231 232 Fusiform muscles are spindle shaped with a round, thick belly e.g., biceps brachii. Quadrate muscles have four equal sides (L. quadratus, square), e.g., pronator quadratus. Circular or sphincteral muscles surround a body opening or orifice, e.g., orbicularis oris biceps brachii -two heads of attachment e.g. gastrocnemius muscles have two bellies triceps -three heads; the digastric and 233 • 4.2.4 Naming of skeletal muscles. – named on the basis of shape, location, attachment orientation of fibers, relative position, or function.. • 1. Shape: – rhomboideus (like a rhombus), – trapezius (like a trapezium); • 2. based on number of heads of origin: – triceps (three heads), – biceps (two heads). • 3. Location: – pectoralis (in the chest, or pectus), – intercostal (between ribs), 234 • 4. Attachment: – (zygomaticus, – temporialis, – nasalis, – femoris, – tibialis, – sternocleidomastoid (sternum, clavicle, and mastoid process of the skull) • 5. Size: – maximus (large) – minimus (smaller), – longus (long), – brevis (short) 235 • 6.Orientation of fibers: – rectus (straight), – transversus (across), – obliquus (oblique), – orbicularis (circular). • 7. Relative position: – lateral, – medial, – internal, and – external. 236 • 8. Function – adductor – Flexor – levator (lifter) • Origin - extensor - pronator – is usually the proximal end of the muscle, the most stationary end, and a thick mid region of a skeletal muscle is known as belly • Insertion – is usually the distal end of the muscle attached to the bone undergoing the greatest movement. 237 Muscle Attachements 238 Nerves to muscles cont… • Muscles of the head and neck innervated by cranial nerves, that emerges from the base of the skull foramina. • Not all skeletal muscles are innervated by cranial nerves. • Others innervated by spinal nerves, which originate from a spinal cord through intervertebral foramina and branches to dorsal and ventral ramus. 240 241 242 •Antagonistic & Synergistic Muscles • Muscles that perform opposite actions (one contracts while other relax) are called antagonistic muscules. e.g: Biceps brachii & triceps • Synergistic Muscles- are muscles that perform similar actions ( both contract as well as relax at the same time) 243 Muscles of the Head & Neck Muscles of the facial expressions Frontalis . Platsma Orbicularis oculi .Temporalis Nasalis . Occipitalis Lavator labii superioris . Bussinator Orbicularis oris Masseter Depressor labii inferioris Depressor anguli oris 244 Temporalis Frontalis Occipitalis Orbicularis oculi Sternocleidomastoid Zygomaticus Orbicularis oris Masseter 245 246 Muscles of chewing & Swallowing Function: Food manipulation, tongue mov`t chewing and swallowing. a) Extrinsic muscles of the tongue o The tongue is a very agile organ; both intrinsic and extrinsic muscles controls its complex movements. • Intrinsic muscles - consists of variable numbers of vertical, transverse and longitudinal fascicles. 247 Muscles of chewing Produce the biting and chewing movements of mandible . - temporalis - masseter - pterygoid ( 2 pairs) The three muscles are innervated by mandibular nerves. 248 Muscles of the trunk Muscles of respiration - Diaphragm - Internal / External intercoastal muscles Muscles of anterior abdominal wall - External abdominal oblique - Internal abdominal oblique - Transverse abdominal - Rectus abdominis 249 Internal Intercostal External Intercostal Diaphragm 250 Muscles of the Back • These muscles primarily extend , rotate, and laterally flex the vertebral column. - latismus dorsi - trapizius - serratus muscles - erector spine - illiocostalis - longismus and spinalis muscle 251 Latissmus Dorsi Extend, Adduct & Rotate Arm Medially 252 Trapezius Infraspinatus Deltoid Teres major Teres minor Latissimus dorsi Gluteus medius Gluteus maximum Iliotibial tract 253 Muscles of the pelvic floor • The floor of the pelvic cavity is formed by 3 layers of muscles and fasciae that span the pelvic outlet and supports the viscera. • It is penetrated by the anal canal, urethra, and vagina, which opens in to a diamond shaped region called perineum. • The perineum is bordered by four bony land marks. 254 - Muscles of pelvic floor are divided in to 3 compartments: . Superficial perineal space - ischiocavernosus - bulbospongiosus - superficial transverse perineal are innervated by pudendal nerve. . Middle compartments - external urethral sphincter - external anal sphincter 255 - deep transverse perineal muscle Pelvic diaphragm • are the deepest compartments • Muscles present in this region are: - lavetor ani and - coccygus 256 Muscles of the shoulder & upper limb • These muscles are used for the rotation, elevation, depression, protraction , flexion extension, adduction and abduction of pectoral girdle and upper limbs. - trapizius - triceps - serratus muscle - Biceps brachii - pectoralis - Brachialis - levator scapulae - rhomboidus 257 - deltoid …. etc Deltoid Abduct, Flex & Extend Arm Posterior Brachium Anterior Brachium Trapezius Deltoid Deltoid Brachialis Biceps brachii Triceps brachii Latissimus dorsi Flexor carpi ulnaris Brachioradialis 258 Pectoralis major Deltoid Serratus anterior Serratus anterior External oblique Rectus abdominis External Oblique Aponeurosis of external oblique Transverse abdominis Internal oblique 259 Pectoralis major Deltoid Serratus anterior Serratus anterior External oblique Rectus abdominis External Oblique Aponeurosis of external oblique Transverse abdominis Internal oblique 260 Muscles of wrist Hand • Fore arm ( anterior compartment) .superficial muscles: - Flexor Carpi radialis - Flexor Carpi ulnaris - Flexor digitorium superficialis - Palmaris longus . Deep muscles - Flexor digitorium profondus - Flexor pollicis longus 261 Brachioradialis Brachialis Brachioradialis Biceps brachii Pronator teres Palmaris longus Flexor carpi radialis Flexor carpi ulnaris Flexor carpi ulnaris Extensor carpi ulnaris Extensor carpi radialis Extensor digitorum Abductor policis longus 262 Fore arm ( posterior compartment) .Superficial - Extensor digitorium - Extensor Carpi radialis - Extensor Carpi ulnaris - Extensor Carpi radialis Brevis - Extensor digiti minimi .Deep - Adductor pollici longus - Extensor pollici brevis 263 Cont… • Flexor carpi—Flexes wrist • Extensor carpi—Extends wrist • Flexor digitorum—Flexes fingers • Extensor digitorum—Extends fingers • Pronator—Pronates • Supinator—Supinates 264 Cont… - Extensor pollici longus - Extensor Indicis Muscles Acting on Hip and Lower Limb . The largest muscles are found in the lower limb - Hip and Femur muscles - Illiocus - psoas - obtrator externus are some anterior muscles of the Hip 265 266 - Gluteus maximus/ medius/minimus - Tensor facia latae - Biceps femoris - Rectus muscle …etc Muscles acting on the Thigh & Foot - Biceps femoris – most lateral muscle of the group - Semitendinosus – medial to biceps femoris. - Semimembranosus – deep to semitendinosus. 267 Cont… - Sartorius - Gracilis - Pectineus – on proximal thigh - Adductor longus – large muscle mass forming medial aspect of thigh. - Quadriceps femoris (3) . Rectus femoris . Vastus medialis . Vastus lateralis 268 Gastrocnemius Soleus Calcaneal tendon 8 of 11 269 Tibialis anterior Peroneus longus Extensor digitorum longus Gastrocnemius Soleus 270 The Nervous System • is divided into • the Central Nervous System (CNS), – the brain – spinal cord • the Peripheral Nervous System (PNS), – the cranial nerves – the spinal nerves – The Autonomic Nervous System (ANS). • sympathetic 271 • parasympathetic divisions Nervous Tissue: Neurons Neurons = nerve cells Cells specialized to transmit messages Major regions of neurons Cell body – nucleus and metabolic center of the cell Processes – fibers that extend from the cell body (dendrites and axons 272 Neuron Anatomy Cell body Nucleus Large nucleolus 273 Neuron Anatomy Extensions outside the cell body Dendrites – conduct impulses toward the cell body Axons – conduct impulses away from the cell body (only 1!) 274 Axons and Nerve Impulses Axons end in axonal terminals Axonal terminals contain vesicles with neurotransmitters Axonal terminals are separated from the next neuron by a gap Synaptic cleft – gap between adjacent neurons Synapse – junction between nerves 275 Neuron Classification 276 Structural Classification of Neurons • Multipolar neurons – many extensions from the cell body 277 Structural Classification of Neurons • Bipolar neurons – one axon and one dendrite 278 Structural Classification of Neurons • Unipolar neurons – have a short single process leaving the cell body 279 Support and protection of NS • The entire delicate CNS is protected by: –a bony –the meanings, –the cerebrospinal fluid (CSF 280 281 CNS • The Brain -lies within the cranial vault - Its hemispheric surface is convoluted and has gyri and sulci. - It consists of: . Cerebrum . Cerebellum . Brain stem . Diencephalons 282 283 284 • The cerebrum consists of two layers. • white matter – Beneath the cerebral cortex – constitutes the second layer. • cerebral cortex – The surface layer – is composed of gray matter( nerve cell bodies.) – has numerous folds and grooves called convolutions. – The elevated folds of the convolutions are the cerebral gyri (singular, gyrus) – the grooves are the cerebral sulci (singular, 285 sulcus). • Lobes of cerebrum • Each cerebral hemisphere is subdivided into 5 lobes by deep sulci called fissures; –The central sulcus (fissure of Rolando) • b/n the frontal lobe and the parietal lobe. – The lateral sulcus (fissure of Sylvius) • b/n the frontal and parietal lobes. 286 287 288 289 290 Functions of Cerebrum • Lobes • Frontal – voluntary motor functions – planning, mood, smell and social judgement • Parietal – receives and integrates sensory information • Occipital – visual center of brain 291 2. Diencephalon –isis the second subdivision of the forebrain and – almost completely surrounded by the cerebral hemispheres –is located b/n the telencephalon and mesencephalen 292 • Divide in to: – thalamus – hypothalamus – the epithalamus –the third ventricle and associated structures, • The 3rd ventricle forms a cavity on the median plane within thediencephalon 293 294 • a. Thalamus: –a paired, large, avoid mass of gray matter, constituting nearly 4/5th of the diencephalon. –Each portion is located immediately below the respective lateral ventricle. – Its principal function is to act as a relay center for all sensory impulses, except smell, to the cerebral cortex. 295 • . Hypothalamus: – a small portion of the diencephalon which forms the floor and part of the lateral walls of the third ventricle. – The hypothalamus performs numerous vital functions, . – hormone secretion (pituitary) – autonomic NS control – thermoregulation (thermostat – food & water intake (hunger & satiety) – sleep & circadian rhythms 296 – memory (mammillary bodies • emotional behavior –anger, aggression, fear, –pleasure, sex drive, orgasm c. Epithalamus: – the dorsal portion of the diencephalon that includes a thin roof over the third ventricle. – The inside lining of the roof consists of a vascular choroids plexus where CSF is produced. – The pineal gland extends outward from the posterior end of the epithalamus. 297 d. Pituitary gland (hypophysis): –is supported by the sella turcica of the sphenoid bone –positioned on the inferior aspect of the diencephalon and is attached to the hypothalamus by a stalk-like structure called the infundibulum. – The pituitary gland is divided into: • anterior portion(adenohypophysis) and • posterior portion( the neurohypophysis). 298 3. The brain stem –The brain stem contains nuclei for autonomic functions of the body and their connecting tracts. – It is the portion of the brain that attaches to the spinal cord and –includes • the midbrain • pons • medulla oblongata 299 300 301 Medulla oblongata • is a bulbous structure B/N pons anteriorly and the spinal cord posteriorly, at the level of the foramen magnum . • is connected to the cerebellum by the inferior cerbellar peduncle. • It consists of – the pyramids- elevated structures on the inferior side • the pyramidal region is the deccussation site cranial tracts – the olive -an oval enlargement, on each 302 lateral surface 303 • 4. Cerebellum – is the second lager structure in the brain. – occupies the inferior and posterior aspect of the cranial cavity. – attached to the brain stem by three paired bundles of nerve fibers called cerebellar peduncles • Superior -to MID BRAIN • middle-PONES • inferior. –to MO – is separated from the overlying cerebrum by a transverse fissure. – The tentorium cerebelli • separates it from the occipital and temporal 304 lobes. • The cerebellum consists of – two hemispheres – the vermis- a central constricted area • function – Balance • coordinating skeletal muscle contractions by recruiting precise motor units within muscles. • Impulses for voluntary muscular movement originate in the cerebral cortex and are coordinated by the cerebellum. 305 306 . Meninges –membranous coverings 0f CNS –Are three layers from outside to inside • the dura mater • the arachnoid mater • the pia mater. 307 • The dura mater – is in contact with bone – is composed primarily of dense connective tissue. – The cranial dura mater is a double-layered structure. • The thicker outer periosteal layer adheres tightly to the cranium. • The thinner, inner meningeal layer follows the general contour of the brain. 308 • The spinal dura mater is single layered and is similar to the menigeal layer of the cranial dura mater. The arachnoid mater is the middle of the three meninges. The subarachnoid space is located between the arachnoid mater and the pia mater. The subarachnoid space contains the CSF 309 • The pia mater – is the deepest meninx attached to the surfaces of the CNS – It is composed of modified loose fibrous connective tissue. – It is highly vascular and . – The ligamentum denticulatum is the lateral extensions of the pia mater which attaches the spinal cord to the dura mater. – Both the pia mater and the arachnoid mater specialize over the roofs of the ventricles to 310 form the choroid plexuses. • Cerebrospinal fluid • is secreted by choroidal epithelial cells (ependymal cells) of the choroid plexuses in the lateral, 3rd, and 4th ventricles – Fills the space between • the arachnoid and pia mater • ventricles • spinal cord. • Functions: – Shock absorption – Support 311 – Nourishment • About 500mL of CSF is produced per day. • The total volume of CSF at any given moment is 150mL • CSF circulates from the choroid plexus through the ventricles and the central canal of the spinal cord. • As it circulates, there is unrestricted diffusion between it and the CSF of the CNS. 312 • Spinal cord • extends through the vertebral canal • is surrounded by three meninges • provides a means of neural communication to and from the brain through tracts of white matter. • These are: – Ascending tracts – Descending tracts • serves as a center for spinal reflexes. 313 • External Morphology • Location –, in adults, from the foramen magnum to the lower border of the first lumbar vertebra – in newborns, it extends to the third lumbar vertebra. –is continuous with the medulla oblongata at the spinomedullary junction 314 • Attachments • 1. Denticulate ligaments – are two pial tissue that attach to the spinal dura with about 21 teeth. • 2. Filum terminale – islower extetion of a pial filament from the conus medullaris. • 3. Spinal nerve roots – provide the strongest anchorage and fixation of the spinal cord to the vertebral canal 315 Shape –is nearly cylindrical structure, –is approximately 1 cm in diameter. –has cervical (C5-T1) lumbar (L1-S2) enlargements for the nerve supply of the upper and lower extremities (the brachial and lumbosacral plexuses, respectively) –terminates caudally as the conus medullaris. –averages in length 45 cm in males and 42 cm in females 316 • Surface structures and sulci – underlie the pia mater and include. • 1. Ventral/ anterior median fissure – is a deep ventral midline groove underlying the ventral spinal artery • 2. Dorsal/ posterior median sulcus – is a shallow dorsal midline groove that is continuous with the dorsal median septum • 3. Ventral lateral sulcus – is a shallow groove from which the ventral rootlets emerge. 317 3. Ventral lateral sulcus is a shallow groove from which the ventral rootlets emerge • 4. Dorsal lateral sulcus – is a shallow groove into which the dorsal rootlets enter 318 • . Internal Morphology – in transverse sections, the spinal cord consists of central gray matter and peripheral white matter. • A. Gray matter – is located centrally within the spinal cord – is butterfly- or H- shaped in a configuration that varies according to spinal cord level. – contains a central canal. – is divided into three horns or cell columns on each side 319 320 • 1. Dorsal/ posterior horn – receives and processes sensory input • 2. Lateral horn – receives viscerosensory input. – is found between the dorsal and ventral horns. – extends from (C8) T1 to L3 – is found at all levels. • 3. Ventral/anterior horn – contains predominately motor nuclei. – is found at all levels. 321 322 • the white matter –Tracts of the spinal cord • are divided into ascending and descending pathways. –Ascending spinal Tracts • Represent functional pathways that convey sensory information from soma or viscera to higher levels of the neural axis. • Usually decussate before reaching their final destination 323 - Usually decussate before reaching their final destination –Descending spinal Tracts • are concerned with somatic and visceral motor activities. • Have their cells of origin in the cerebral cortex or in the brainstem cord 324 • The peripheral nervous system –is that portion of the nervous system outside the CNS. –The PNS functions to convey impulses to and from the brain or spinal cord. –The nerves of the PNS are classified as • cranial nerves or • spinal nerve 325 • Cranial nerves –There are 12 pairs of cranial nerves – The cranial nerves are designated by roman numerals –Their names indicate the structures innervated or the principal functions of the nerves 326 Olfactory Nerve .Sense of smell .Damage causes impaired sense of smell 327 Optic Nerve -Provides vision -Damage causes blindness in visual field 328 Oculomotor Nerve Eye movement, opening of eyelid, constriction of pupil, focusing Damage causes drooping eyelid, dilated pupil, double vision, difficulty focusing and inability to329 move eye in certain directions Trochlear Nerve -Eye movement (superior oblique muscle) -Damage causes double vision and inability to rotate eye inferolaterally 330 Trigeminal Nerve ..Sensory to face (touch, pain and temperature) and muscles of mastication ..Damage produces loss of sensation and impaired chewing 331 Abducens Nerve -Provides eye movement (lateral rectus m.) -Damage results in inability to rotate eye laterally and at rest eye rotates medially 332 Facial Nerve 333 • Motor - facial expressions; salivary glands and tear, nasal and palatine glands • Sensory - taste on anterior 2/3’s of tongue • Damage produces sagging facial muscles and disturbed sense of taste (no sweet and salty) 334 Vestibulocochlear Nerve -Provides hearing and sense of balance -Damage produces deafness, dizziness, nausea, loss of balance and nystagmus 335 Glossopharyngeal Nerve 336 • Swallowing, salivation, gagging and respiration • Sensations from posterior 1/3 of tongue • Damage results in loss of bitter and sour taste and impaired swallowing 337 Vagus Nerve 338 • Swallowing, speech, regulation of viscera • Damage causes hoarseness or loss of voice, impaired swallowing and fatal if both are cut Accessory Nerve 339 • Swallowing, head, neck and shoulder movement –damage causes impaired head, neck, shoulder movement; head turns towards injured side 340 Hypoglossal Nerve Tongue movements for speech, food manipulation and swallowing if both are damaged – can’t protrude tongue if one side is damaged – tongue deviates 341 towards injured side; see ipsilateral atrophy Spinal nerves –31 pairs of spinal nerves • grouped as –8 cervical –12 thoracic –5 lumbar –5 sacral –1 coccygeal 342 343 • Nerve plexuses –Except in the thoracic nerves T2-T12, the anterior rami of the spinal nerves combine and then split again as networks of nerves referred to as plexuses. –There are four plexuses: • the cervical • the brachial • the lumbar • sacra 344 • Cervical plexus – formed by the anterior rami of the nerves C1 - C4 and a portion of C5. – Branches of this innervate the skin and muscles of the neck, and portions of the head and shoulders. –E.g. Fibers from C3, C4, and C5 unite to form the phrenic nerve, which innervates the diaphragm thereby causing it to contract during inspiration 345 • Brachial plexus –It’s formed by the anterior rami of the nerves C5 - T1 with contributions from C4 and T2. –Five major nerves • the axillary • radial • musculocutaneus • ulnar • median nerves –arise from this to supply sensory and motor innervation to the upper limb 346 • Lumbar plexus – It’s formed by the anterior rami of spinal nerves L1 and L4 and some fibers from T12. – Branches from this innervate structures of • the lower part of abdomen • anterior and medial potions of the lower limb. – E.g. femoral nerve innervates the anterior muscles of the thigh – obturator nerve innervates the medial adductor muscles of the thigh 347 • Lumbar plexus – It’s formed by the anterior rami of spinal nerves L1 and L4 and some fibers from T12. – Branches from this innervate structures of • the lower part of abdomen • anterior and medial potions of the lower limb. – E.g. femoral nerve innervates the anterior muscles of the thigh – obturator nerve innervates the medial adductor muscles of the thigh 348 • The sciatic nerve – is the largest branch of the sacral plexus and is the largest nerve in the body. – It’s composed of two nerves• the tibial • common fibular nerves. • Tibial nerve – innervates most of the posterior thigh and leg muscles and many of the plantar muscles. 349 Eyeball • spherical in shape with anterior and posterior poles • suspended in anterior half of orbital cavity • The wall is composed of three concentric coats (tunics) – fibrous, vascular, and sensory • The internal cavity is fluid filled with humors – aqueous and vitreous • The lens separates the internal cavity into anterior and posterior segments 350 Layers of the eyeball • Three layers : • Fibrous layer (outer coat), consisting of the sclera and cornea. • Vascular layer (middle coat), consisting of the choroid, ciliary body, and iris. • Inner layer (inner coat), consisting of the retina, which has both optic and non-visual parts. 351 352 Fibrous Tunic • Forms the outermost coat of the eye and is composed of – Opaque sclera (posterior) – Clear cornea (anterior) • Sclera – protects the eye and anchors extrinsic muscles – form posterior 5/6 of eye ball – posteriorly perforated for passage of optic nerve – continues anteriorly with cornea at sclerocorneal junction (limbus) – inner part of limbus contains circular canal called sinus venosus sclerae (canal of Schlemm) – posteriorly fused with dura of optic nerve – it provides insertion to extrinsic muscles – pierced by optic nerve, ciliary ganglion, anterior ciliary arteries, choroids veins 353 – it is avascular • Cornea – transparent and avascular – lets light enter the eye – forms anterior 1/6 – more convex than sclera – made up of special connective tissue 354 Vascular Tunic (Uvea) • Has three regions: choroid, ciliary body and iris • Choroid region – Supplies blood to all eye tunics – Anteriorly ends at oraserrata by merging with ciliary body – Posteriorly pierced by optic nerve – Attached to sclera loosely and retina firmly – Contain venous plexus and capillaries • Ciliary Body – A thickened ring of tissue surrounding the lens – Connects choroids with iris – Composed of smooth muscle bundles (ciliary muscles) and ciliary processes – Anchors the suspensory ligament that holds the lens in place 355 • Iris – The colored anterior part of the eye – Posses pigment cells; determine eye color – Form circular curtain with opening at center called pupil – Regulates the amount of light entering the eye by 2 muscles • Sphincter pupillae (ring muscle) • Dilator pupillae (radial muscle) – Close vision and bright light – pupils constrict – Distant vision and dim light – pupils dilate 356 Sensory Tunic: Retina • A delicate membrane between choroids and vitreous body • Composed of two layers: – Pigmented layer – the outer layer that absorbs light and prevents its scattering – Neural layer – inner layer which contains: • Photoreceptors that transduce light energy • Bipolar cells and ganglion cells – Ganglion cell axons: run along the inner surface of the retina and leave the eye as the optic nerve – The optic disc: • A circular depression at the site where the optic nerve leaves the eye • Lacks photoreceptors; it is insensitive to light thus called the blind spot 357 • The optic disc is the blind spot of the eye because it lacks rods and cones. • Lateral to optic disc at posterior pole is a small oval yellowish area called macula lutea; at center is depressed area called fovea centralis (site of maximum acuity of vision) 358 The Ear • The ear is the organ of hearing & balance • divided into three parts: • External ear: – auricle – external auditory meatus • Middle ear (or tympanum, tympanic cavity): – tympanic membrane – tympanic cavity & antrum – pharyngotympanic tube (or auditory tube, or Eustachian tube) • Internal (inner) ear: – osseous (bony) labyrinth – membranous labyrinth 359 The Ear • External ear: is the part attached to lateral aspect of the head & the canal leading inward; it captures sound. • Middle ear (or tympanum, tympanic cavity): • is a cavity in the petrous part of the temporal bone • bounded laterally, by a membrane & connected internally to the pharynx by a narrow tube • Internal (inner) ear: • consists of a series of cavities within the petrous part of the temporal bone: b/n middle ear laterally & internal acoustic meatus medially. • it converts mechanical signals from middle ear into electrical signals transferred to the brain. • internal ear also contains receptors that detect 360 motion and position The Ear 361 The Internal Ear Membranous labyrinth: • is a continuous system of ducts & sacs within the bony labyrinth. • It is filled with endolymph & separated from periosteum of bony labyrinth by perilymph. • Consisting of two sacs (utricle & saccule) & four ducts (three semicircular ducts & cochlear duct) • has unique functions related to balance & hearing: utricle, saccule, & three semicircular ducts are part of vestibular apparatus (i.e. organs of balance); 362 363