[Company Logo]
South Bordello Institute of Technology
UNIVERSITY REPORT
Prepared by
Mr. Kendrick J. Strand
kjstrand@email.com
April 15, 2023
TABLE OF CONTENTS
1. Introduction
X
2. Methodology
X
3. Findings & Discussion
X
4. Conclusion
X
5. Recommendations
X
1. Introduction
As a final project for [BIOCHEM 403,] this report covers the monitoring of the toxicity levels of
the compounds [GB-03 and GB-04,] the two most promising subjects in the university’s ongoing
drug trials for [Virus 42. Virus 42] was developed as a gene therapy under the supervision of
[South Bordello Institute of Technology’s Biochemistry Department] and [Research Division.]
[GB-03 and GB-04] are among the project’s biggest milestones in the last three years. The main
problem, however, is the [high toxicity level.]
Research studies by undergraduate students on the [Virus 42] are considered universitysanctioned case studies, and the results will be [official supplementary data] for the project.
This report details the comparative analysis focused on the relative toxicity levels of both
compounds in [two sample sets.] It looked into which chemical is more viable in the next stage
of clinical trials.
2. Methodology
This study used a quantitative approach to determine relative [toxicity.] Specifically, it
employed the method of bioassay, which is the concentration measurement of a substance by
its effect on the living cells or tissues of an organism that is sensitive to the compound used in
the experiment.
The data used in this study included only the basic information of the two compounds used,
and any similarities with official comparative analyses performed by the project itself are
independent of each other.
Subject
LD50 of GB-03
Sample Set A
12 mg
Sample Set B
43 mg
[LD50,] or the median lethal dose, is the dose required to kill [50%] of the test population. For
this study, the two sample sets are both microorganisms grown in the university’s biochemistry
lab.
Subject
LD50 of GB-04
Sample Set A
17 mg
Sample Set B
43 mg
For the second set of test populations, the same microorganisms were used.
The focus of the comparison was primarily the median lethal dose of the two compounds, [GB03 and GB-04,] on the same microorganisms that were deemed to exhibit the same biological
properties used in the official drug trials.
3. Findings & Discussion
The results of the bioassay tests and the subsequent comparative analysis showed that there is
a difference in the toxicity levels of the compounds [GB-03] and [GB-04] in the microorganisms
used for the sample sets.
Subject
LD50 of GB-03
LD50 of GB-04
Sample Set A
12 mg
17 mg
Sample Set B
43 mg
43 mg
For Sample [Set A,] the compound [GB-03] had a median lethal dose of [12 mg], while the
compound [GB-04’s LD50] result was [17] mg. The lower the median lethal dose is in a test
case, the higher the toxicity is. This means that the toxicity level of the compound [GB-03] is
higher than that of [GB-04] for the microorganisms in the Sample [Set A] since it takes [5] mg
less of the compound [GB-04] for [GB-03] to kill [50%] of the same sample set or
[microorganism.]
For Sample Set B, on the other hand, both [GB-03] and [GB-04] recorded a median lethal dose
of [43 mg.] This means that it takes the same amount of substance for both compounds to kill
[50%] of the test population in Sample [Set B.]
4. Conclusion
This study concludes that there is a difference in toxicity levels between the compounds [GB03] and [GB-04.] Specifically, the median lethal dose of [GB-03] is [5mg] lower than [GB-04] in a
sample set of the microorganisms introduced in the experiment. This means that in at least one
type of organism, the compound [GB-03] showed [higher toxicity.]
The results of this study also showed that there are significant similarities in toxicity levels
between both compounds, as the median lethal dose of both is relatively the same in another
sample set of [microorganisms.]
5. Recommendations
Based on the data presented above, the following courses of action are recommended:
5.1. Expand the comparative analysis of both compounds to include other sample sets from
different organisms.
5.2. Conduct a comparative study using a different method of assessing toxicity levels of the
compounds to have a basis of comparison for this bioassay study.
To Use This Documents
The text inside the brackets which is highlighted is meant to be edited with your
text. This is the way you can edit the document as given below:
To Edit Text:
Point the mouse where you want to edit and delete the sample text and
then you can add your text.
You can change the size, font & color of the text in the Main Tab: Home
To Edit Table:
Point the mouse in the table where you want to edit and delete the sample
text and then you can add your text.
You can adjust the row & column size of the table in the Main Tab: Layout
To Edit Chart:
Select the chart which is going to edit and then
In Main tab: Design -> Edit Data
It will open the excel sheet where you can edit the values of the chart