PATHOPHYSIOLOGY OF ACUTE GLOMERULONEPHRITIS
THERE IS AN INFECTION IN THE BODY THAT TRIGGERS
THE IMMUNOLOGICAL RESPONSE
ANTIGENS FORMS IMMUNE COMPLEX
DEPOSITION OF GLOMERULI
SYSTEMIC CIRCULATION
MEMBRANE PERMEABILITY
KIDNEY INFLAMMATION
REDUCED GLOMERULAR FILTRATION
KIDNEY DYSFUNCTION
RETENTION OF SODUIM AND WATER
PROLIFERATION OF CELLS CAUSES BLOCKAGE
CHRONIC
END-STAGE RENAL DISEASE
SIGNS AND SYMPTOMS
EDEMA
PROTEINURIA
HEMATURIA
HYPERTENSION
FATIGUE
OLIGURIA
DYSPNEA
NAUSEA & VOMITING
.
HEADACHE
MUSCLE CRAMPS
PHARMACOLOGIC THERAPY
LOOP DIURETICS
THIAZIDE DIURETICS
POTASSIUM-SPARING
DIURETICS
OSMOTIC DIURETICS
CARBONIC ANHYDRASE
INHIBITORS
Furosemide - alleviates fatigue associated with fluid
overload and reduces edema, can increase urine output, used
to relieve dyspnea associated with pulmonary congestion
and fluid overload in glomerulonephritis and cardiovascular.
It inhibits reabsorption of sodium and chloride ions that
leads to diuresis.
Hydrochlorothiazide (HCTZ)- managing hypertension and
reduces edema and can lead to increased urine and
decreased blood volume. It also decreases proteinuria
alongside taking loop diuretics. It increases the elimination
of sodium and chloride by inhibiting the reabsorption of
sodium and chloride in the distal convoluted tubules in the
kidneys.
Spironolactone- help preserve potassium levels and may
prevent or alleviate muscle cramps associated with
potassium depletion. Reduces sodium reabsorption at
the distal tubule, thus decreasing potassium secretion.
Mannitol - is used in treating Acute Kidney Injury due to
Glomerulonephritis, it increases the urine output to reduce
the risk of fluid overload. Osmotic diuretics are also used
to treat Cerebral Edema caused by Glomerulonephritis by
reducing the intracranial pressure. Prevents the
reabsorption of water, sodium, and chloride.
Acetazolamide - used to treat metabolic alkalosis
caused by glomerulonephritis by helping promote the
excretion of bicarbonate ions in the urine, it may also
be used as an option for treating edema caused by
.
glomerulonephritis.
GROUP 2F2 MEMBERS:
Angeles, Joanna Charlisse
De Castro, Argell
Magahis, Jen Laurca
Mones, Yesha Nicole
Pillado, Charmaine Angelie
Quiatchon, Maria Florezel F.
Reyes, Liv Alessandra N.
Rogelio, Althea
Sorrera, Alphajacel
Cruz, Jason
Saguid, Josh Ashwell
.