Taxi to the ISS - Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases Dr. Anis Karim Master of Science in Space Studies 2004-2005 International Space University Strasbourg, France Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases ABSTRACT Introduction: The objective of this study is to give an insight into the medical guidelines to be followed for the selection of space tourists for taxi flights, with respect to the cardiovascular and neurological diseases, and the inflight countermeasures, monitoring and treatment that can be provided. Methods: For every disease, the possible countermeasures, monitoring and treatment that could be provided onboard the International Space Station were studied. Results: The information obtained was then analyzed for a compare-and-contrast study of the cardiovascular and neurological diseases. It was inferred that simple countermeasures could be effectively provided on the ISS for space tourists with cardiovascular and neurological diseases, without extra onboard hardware. In the case of monitoring, cardiovascular diseases can be easily monitored onboard the ISS, while neurological diseases require a trained astronaut for the same. Although treatment is diseasespecific, since many diseases have common symptoms, a general symptomatic line of management can be undertaken. A practical guideline was also proposed for passenger selection. Conclusions: This study shows that diseases are not obstacles in the path of people who want to enjoy the excitement of space travel. Most of the cardiovascular and neurological diseases can have practical countermeasures, monitoring and treatment equipment onboard the ISS. Keywords: space tourists, taxi flight, selection guidelines, fitness to fly. International Space University, MSS ‘05 2 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases TABLE OF CONTENTS ABSTRACT…………………………………………………………………...2 INDEX OF FIGURES………………………………………………………...4 INDEX OF TABLES………………………………………………………….4 1 2 INTRODUCTION………………………………………………….…..5 1.1 THE NEED……………………………………………………………5 1.2 THE OBJECTIVE……………………………….……………….…..5 METHODS……………………………………………………………..6 2.1 TERMINOLOGY……………………………………………………..6 2.2 METHOD OF STUDY……………………………………………….6 3 RESULTS……………………………………………………………...7 4 DISCUSSION…………………………………………………….…..10 4.1 COUNTERMEASURES……………………………………….…..10 4.2 MONITORING………………………………………………………10 4.3 TREATMENT………………………………………………....11 4.4 PROPOSED SELECTION GUIDELINE…………………………11 5 CONCLUSIONS & RECOMMENDATIONS………….…………..13 6 REFERENCES………………………………………………………15 7 APPENDIX A………………………………………………………...16 8 APPENDIX B……………………………………………………...…20 International Space University, MSS ‘05 3 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases INDEX OF FIGURES Figure 4-1: Flowchart showing the proposed guideline for passenger selection……………………………………………………....12 INDEX OF TABLES Table 3-1: Results for cardiovascular diseases…………………………7 Table 3-2a: Results for neurological diseases……………………………8 Table 3-2b: Results for neurological diseases……………………………9 International Space University, MSS ‘05 4 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases 1 INTRODUCTION The age of Space Tourism has dawned with the flights to the International Space Station, of Dennis Tito and Mark Shuttleworth. The so-called ‘Taxi Flight’ is a round-trip to the ISS, on the Russian Soyuz spacecraft, with stays of 6 to 8 days on the ISS. The crew goes up on a new Soyuz with the provisions to the ISS; and returns in the old Soyuz that had been attached to the ISS during the previous mission. With more and more individuals ready to pay for the third seat on the Soyuz for an unforgettable journey of their lifetime, there is an inherent demand for widening the selection criteria for space travelers, so as to allow the ‘not-so-perfectly-healthy’ aspirants also to feel the excitement of space travel. The lack of established guidelines for space tourists poses a great difficulty for passenger selection. 1.1 THE NEED In 2001, when the financially-constrained Russian Aviation and Space Agency decided to launch US millionaire, Dennis Tito, on a Soyuz taxi mission to the ISS for USD 20 million, NASA immediately opposed the plan, citing a number of reasons. One reason was that the station partners had not yet agreed upon a guideline policy for selecting visiting crewmembers to the ISS. Despite the objections, the Russians went forward with the launch, and thus Dennis Tito became the first paying space tourist (April 2001). However, the station partners made headway on selection criteria for ‘spaceflight participants’, and came up with a nine-page document entitled ‘Principles Regarding Processes and Criteria for Selection, Assignment, Training and Certification of ISS (Expedition and Visiting) Crewmembers’ (Halvorson 2002). Surprisingly, the criteria lacked detail on medical and training requirements, and were focused more on behavior and conduct. This leaves room for the involved space agencies to define their own medical criteria. To this end, new selection criteria for spaceflight participants is the need of the hour. 1.2 THE OBJECTIVE The objective of this study is to give an insight into the medical guidelines to be followed for the selection of space tourists for taxi flights, with respect to the cardiovascular and neurological diseases, and the inflight countermeasures, monitoring and treatment that can be provided. International Space University, MSS ‘05 5 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases 2 METHODS The primary data for disease disqualification/exception was obtained from the Aerospace Medical Association Task Force on Space Travel report (2001). The exception cases were further evaluated to propose possible inflight countermeasures, monitoring and treatment. 2.1 TERMINOLOGY For the purpose of this study, the following terminology was used: A cause for disqualification is defined as ‘any medical condition or treatment regimen which could endanger the health of the passenger, fellow passengers, or crew; compromise safety inflight or on the ground; or pose a threat to completion of the flight’ (Aerospace Medical Association Task Force on Space Travel 2001). An exception means ‘further evaluation has to be done, depending on the condition of the passenger and the circumstances of the flight.’ Countermeasures means ‘the possible measures that could be undertaken inflight, to prevent the worsening or recurrence of the disease or its complications.’ Monitoring refers to ‘the possible means to monitor the passenger inflight, for any symptoms related to the disease.’ Treatment is defined as ‘the possible inflight treatment measures to control the symptoms, if they occur, and thus control the disease, until the passenger returns to ground for normal treatment procedures.’ 2.2 METHOD OF STUDY First, for a particular disease or condition, the possible countermeasures that could be provided on the ISS were probed. Then, the onboard facilities for periodic or continuous monitoring were looked into. Then, the onboard treatment measures that could be provided, if the disease worsens in spite of all the undertaken countermeasures, were explored. As the Soyuz spacecraft used for taxi flights has only limited workspace and minimal onboard medical equipment (to measure pulse, blood pressure, etc.), the countermeasures, monitoring and treatment procedures proposed here are more applicable to the ISS, although some may fit to Soyuz also (Zak 2005). As such, the medical risks related to the Soyuz phase of the flight (2 days to go to ISS and 3 hours to come back) have not been evaluated. International Space University, MSS ‘05 6 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases 3 RESULTS The results of the study are given in the tables 3-1, 3-2a and 3-2b. Disease / Condition Cardiovascular Counter measures Onboard Monitoring Onboard Treatment Low-fat diet, exercise, control blood pressure, stress management ECG Medication (beta(Electrocardiogram), blockers, Calciumechocardiogram, blood channel blockers, pressure, pulse, ACE inhibitors, respiratory rate etc.), low-fat diet Arrythmias / Conduction Defects (Nonhemodynamically significant) e.g.: Atrial fibrillation A well-balanced, low-fat diet, regular exercise ECG, echocardiogram, blood pressure, respiratory rate, heart rate and rhythm (pulse) Pericarditis / Myocarditis (6 months postrecovery) Medication, exercise, relieve stressful and riskful activities, salt restriction ECG, echocardiogram, blood pressure, pulse, respiratory rate, temperature Hypertension (Well controlled) Medication, exercise, relieve stressful and riskful activities, low-salt diet Blood pressure, pulse Structural / Valvular Defects (Asymptomatic) e.g.: Mitral valve prolapse Antibiotics to prevent infection ECG, echocardiogram, doppler examination, blood pressure, respiratory rate, heart rate and rhythm (pulse) Cardiomyopathy (Asymptomatic) Exercise, salt restriction ECG, echocardiogram Coronary Artery Disease (Asymptomatic) Anti-arrhythmic medication Corticosteroids, aspirin, salt restriction, diuretics, ACE inhibitors Emergency: sodium nitroprusside, labetalol. Continue medication Antibiotics, antiarrhythmics, vasodilators, digitalis, diuretics, propranolol, anticoagulants Digoxin, diuretics, vasodilators, ACE inhibitors, beta blockers, cordarone Table 3-1: Results for cardiovascular diseases International Space University, MSS ‘05 7 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases Disease / Condition Neurological Multiple Sclerosis (Certified fit after evaluation) Parkinson’s Disease (Certified fit after evaluation) Counter measures Onboard Monitoring Onboard Treatment Exercise, wellbalanced diet, avoid fatigue and stress, reduce factors that may trigger an MS attack Abnormal reflexes, decreased movement, speech and vision changes, nystagmus, tremor, weakness Interferon, glatiramer acetate, corticosteroids (prednisone), benzodiazepines, amantadine. Exercise, adequate rest and relaxation Exercise, wellbalanced diet, avoid stress, Regular rest periods Tremor, Rigidity, Depression, Emotional changes (Anxiety, stress, and tension), Difficulty in swallowing and chewing, Speech changes, Urinary problems or constipation, Excessive sweating, Sleep problems, Dyskinesias, Muscle aches and pains (myalgia) Medication (levodopa + carbidopa, amantadine, Deprenyl, Anticholinergics, Selegiline, Bromocriptine, pergolide, pramipexole and ropinirole) Weakness, or paralysis, speaking, swallowing, or vision, breathing, consciousness level. Carotid Doppler, Echo, ECG (EKG), Holter monitor, Heart rate & Rhythm Tissue Plasminogen Activator, early use of Heparin and Aspirin. Oxygen may be administered when necessary. Analgesics & antihypertensives. Nutrients and fluids Cerebral Vascular Disease (Stroke) (Certified fit after evaluation) Control blood pressure, cholesterol, diabetes and any heart disease. Continue medication, lowfat diet. Exercise regularly. Seizure disorder (Epilepsy) (A reasonable seizure-free period) Adequate diet and sleep, NA medication, (Electroencephalogram prevent triggering [EEG] in research factors. Avoid phase) risk of head injury. Oral anticonvulsants (Phenobarbital) Table 3-2a: Results for neurological diseases International Space University, MSS ‘05 8 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases Disease / Condition Neurological Counter measures Dementia (Certified fit after evaluation) e.g.: Alzheimer's disease Control high blood pressure and diabetes. Eat a low-fat diet. Regular exercise. Intracerebral Neoplasm (Brain Tumor) (Certified fit after evaluation) Continue medication, reduce fluid intake to decrease the chance for edema Fixed Neurological Deficit Due to Any Cause (Certified fit after evaluation) Continue medication Onboard Monitoring Onboard Treatment Medication (Antipsychotics, Serotonin-affecting drugs (trazodone, buspirone), Dopamine blockers (haloperidol, Risperidal, olanzapine, clozapine)) Corticosteroids Changes in (dexamethasone), personality or osmotic diuretics memory, speech, (urea or mannitol), vision, weakness, anticonvulsants seizures, headaches, (phenytoin), alertness, muscle analgesics, antacids strength, or histamine coordination, reflexes, blockers to control and response to pain stress ulcers Impairment of attention, orientation, memory, judgment, language, aaltered sleep patterns, personality changes, motor and spatial skills, and function Changes in function of the part affected Specific medication for the cause Table 3-2b: Results for neurological diseases International Space University, MSS ‘05 9 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases 4 DISCUSSION The cardiovascular and neurological diseases were compared and contrasted to get a clear picture. 4.1 COUNTERMEASURES With regard to the cardiovascular diseases studied, it was found that there are common onboard countermeasures that could be provided to all the diseases. These include exercise, continuing medication, controlling blood pressure and having a wellbalanced low-fat diet. This may be attributed to the dynamic nature of the cardiovascular system. Diseases like hypertension, cardiomyopathy and coronary artery disease require reduced salt intake and stress. Structural and valvular defects are unique, as they require prophylactic antibiotic therapy. The neurological diseases require mostly unique countermeasures, which can be attributed to their unique symptoms. As such, a set of common countermeasures can hardly be put forward. For example, stroke requires controlling blood pressure, cholesterol and diabetes, whereas epilepsy requires adequate diet, sleep, medication and preventing triggering factors. But, some diseases were found to have common countermeasures. For example, multiple sclerosis and Parkinson’s disease patients should be prevented from anxiety, stress, fatigue, etc. Of course, regular medication is an absolute requirement for all the neurological diseases. From this study, it is inferred that simple countermeasures can be effectively provided on the ISS for space tourists with diseases, without extra onboard hardware. At the same time, it is interesting to see that the types of countermeasures to be provided are different, within and among the various body systems. 4.2 MONITORING The onboard monitoring for all the cardiovascular diseases is by using the same parameters and hence the same equipment. The pulse and blood pressure can be easily monitored. Facilities for ECG (electrocardiogram), doppler and echocardiogram are also available onboard. As stated earlier, the dynamic nature of the cardiovascular system helps us to monitor all the diseases by measuring few parameters. The need for bulky instruments is avoided by the use of integrated multiple-parameter measuring instruments. For example, sensors placed at the fingertip can measure pulse and partial pressure of oxygen in the blood. At the same time, diseases like pericarditis and myocarditis require additional monitoring of respiratory rate and temperature. In the case of neurological diseases, monitoring is mostly disease-specific or specific to a group of diseases. Impairment of the sensory system has quite different monitoring requirements than that of the motor system. Moreover, most diseases have associated emotional and behavioral changes also. As a result, efficient monitoring can be provided only by a trained astronaut specialized in neurological diagnosis. This could be a constraint for the qualification of the passenger. In the International Space University, MSS ‘05 10 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases case of lesser-trained astronauts, medical guidance from the ground can be of great help in the monitoring process. Telemedicine facilities with real-time or near-realtime two-way communication between the space station and the ground control station are highly desired. So, while there are onboard instruments to monitor the cardiovascular parameters, there are no regularly used instruments for monitoring neurological parameters. It is inferred that cardiovascular diseases can be easily monitored onboard the ISS, while neurological diseases require a trained astronaut for the same. 4.3 TREATMENT As treatment is disease-specific, a generalization cannot be applied. Every disease has to be controlled by its specific oral, intravenous or intramuscular therapy. But, as many diseases have common symptoms, a general symptomatic line of management can be undertaken. The positive factor is that, with the current medical facilities on the ISS, efficient therapy can be initiated to control the symptoms, well before the passenger is moved to a hospital upon returning to Earth. The negative factor lies in the fact that the multi-million dollar mission will most probably not be shortened just to save the life of the passenger. This brings into light the undeniable reality that the passenger should accept the personal risks associated with space travel. 4.4 PROPOSED SELECTION GUIDELINE Fig. 4-1 shows the flowchart describing the proposed guideline for passenger selection. When the status of the passenger falls in the ‘exception’ category, and after further evaluation, he is certified fit for the flight, the next step would be looking into the countermeasures that could be provided onboard the ISS. If the required countermeasures cannot be provided onboard, the passenger becomes disqualified even if he is medically fit. If the required countermeasures can be provided, the next step is evaluating the required onboard monitoring measures. As in the case of countermeasures, qualification for flight depends on the availability of onboard monitoring measures. Likewise, the required onboard treatment measures are also evaluated. Only when all these requirements are met, can the passenger be certified ‘Medically Qualified for Flight.’ International Space University, MSS ‘05 11 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases Fig. 4-1: Flowchart showing the proposed guideline for passenger selection International Space University, MSS ‘05 12 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases 5 CONCLUSIONS & RECOMMENDATIONS This study shows that certain diseases need not be obstacles in the path of people who want to enjoy the excitement of space travel. Most of the cardiovascular and neurological diseases can have practical countermeasures, monitoring and treatment equipment onboard the ISS. However, the implementation of the following recommendations would help more aspirants to realize their dreams. (1) Improvements in the countermeasures, monitoring and treatment measures onboard the ISS to include most, if not all, of the diseases. These diseasespecific measures will help to accommodate every aspiring space tourist. For example, use of EEG (Electroencephalogram) to monitor tourists with a controlled history of Epilepsy. Another option could be a customizable onboard medical system capable of being adaptable to different passenger needs. (2) Measures to manage medical emergencies should be greatly enhanced, so as to cope with any situation that may endanger the life of the tourist. It will in turn help to control the complications, in the case of an unprecedented delay in moving him to a hospital on Earth. For example, use of defibrillator to manage ventricular fibrillation. (3) Development of new and compact automated diagnostic and monitoring systems should be accelerated. For example, ‘Heartache’ is an automated chest pain diagnostic system for distant space travel, being designed at San Jose State University, USA (Wesley 2002). (4) Miniaturization of equipment is highly desired. The current advances in microtechnology and nano-technology should be able to make this happen sooner rather than later. Nanobots and molecular robots are in the horizon. Results of research in these fields should be readily incorporated into the medical sector. (5) Another option could be modification of existing medical equipment to measure multiple parameters. For example, Blood Glucose Monitors can be upgraded to measure cholesterol, ketone bodies, etc. ECG (Electrocardiogram) equipment can be upgraded to measure EEG (Electroencephalogram). This in turn saves space and time, which are limited in spaceflight. Moreover, this provides easy use and management of the equipment. (6) One option for easy drug delivery is to use new methods like skin patches and implants. This makes the onboard life easier for the tourists, since they don’t have to worry about periodic medicine intake and dosage. For example, use of Lidocaine skin patch to treat local pain. (7) The tourists should be allowed to take along with them small instruments and medicines that are not available on the ISS. For example, Blood Glucose Monitors. (8) Regulations regarding space qualification of instruments and technology should be liberalized. The current regulations impose unwanted restrictions to International Space University, MSS ‘05 13 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases the space qualification of new technologies. As such, new and very efficient medical equipment are not allowed to be flown. The opposite would have made the onboard medical management dramatically better. For example, wireless diagnostic and monitoring equipment, wireless electrodes, etc. (9) The proposed guideline for passenger selection can be used effectively for taxi flights, with modifications, if necessary, in the future. As the linear method of selection is simple and efficient, it can be applied to all diseases. The guideline, along with the existing astronaut selection criteria, could be developed into new space tourist selection criteria. The results of this study are in agreement with and complement the report of the Aerospace Medical Association Task Force on Space Travel (2001). However, further study and research are needed to establish efficient space tourist selection criteria. In the coming years, technological advancements would help more and more people to go to space, and ultimately, medical problems may not be a constraint for space travel. International Space University, MSS ‘05 14 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases 6 REFERENCES Aerospace and High Technology Database (Database) 2005, [Online] Available at: http://www.csa.com Aerospace Medical Association Task Force on Space Travel 2001, ‘Medical Guidelines for Space Passengers’, Aviation, Space, and Environmental Medicine, vol. 72, no. 10, pp. 948-950. MedicineNet.com (Medical Dictionary) 2005, [Online] Available at: http://www.medterms.com Medline Plus (Medical Encyclopedia) 2005, [Online] Available at: http://www.nlm.nih.gov/medlineplus/encyclopedia.html Space Passenger Task Force 2002, ‘Medical Guidelines for Space Passengers-II’, Aviation, Space, and Environmental Medicine, vol. 73, no. 11, pp. 1132-1134. Wesley, L. P. 2002, ‘An Automated Chest Pain Diagnostic System for Distant Space Travel’, 2002 IEEE Aerospace Conference proceedings, vol. 7, pp. 7-3311 – 7-3315. Halvorson, T. 2002, ‘Partners Set Standards for Station Tourists; Miscreants Need Not Apply’, space.com, [Online] Available at: http://www.space.com/missionlaunches/iss_guests_020131.html ‘Planned Launch for ISS Expedition 7 Crew and an EVA for Expedition 6’ 2003, starryskies.com, [Online] Available at: http://starryskies.com/articles/2003/04/expedition7.html HeartCenterOnline 2005, [Online] Available at: http://www.heartcenteronline.com/myheartdr/home/index.cfm Zak, A. 2005, ‘SPACECRAFT: Manned: Soyuz’, RussianSpaceWeb.com, [Online] Available at: http://www.russianspaceweb.com/soyuz.html EEG Research 2005, [Online] Available at: http://www.eegresearch.com/index.htm ‘More Products’ 2005, National Nanotechnology Initiative, [Online] Available at: http://www.nano.gov/html/facts/MoreProds.htm International Space University, MSS ‘05 15 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases 7 APPENDIX A Medical Guidelines for Space Tourists (Adapted from: Aerospace Medical Association Task Force on Space Travel 2001, ‘Medical Guidelines for Space Passengers’, Aviation, Space, and Environmental Medicine, vol. 72, no. 10, pp. 948-950) Disease / Condition Cardiovascular Disqualify Exception (Symptomatic) (Hemodynamically significant) (Asymptomatic) (Non-hemodynamically significant) Pericarditis / Myocarditis Heart Transplant / Replacement (6 months post-recovery) Coronary Artery Disease Arrythmias / Conduction Defects Pacemaker / Implantable Defribillators Hypertension Structural / Valvular Defects Cardiomyopathy (Severe or poorly controlled) (Symptomatic) (Symptomatic) Neurological Multiple Sclerosis (Active) Parkinson’s and Other Movement Disorders Cerebral Vascular Disease / Malformations / Aneurysms Seizure disorder Dementia International Space University, MSS ‘05 (Well controlled: Qualified with possible exceptions) (Asymptomatic) (Asymptomatic: Evaluate for qualification) (Evaluate condition and neurological deficit) (Evaluate degree and extent of impairment) (Evaluate for neurological dysfunction and musculoskeletal disability) (A reasonable seizure-free period) (Evaluate cognitive 16 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases Headaches Syncope or Other Disturbance of Consciousness (Frequent, severe or incapacitating, particularly migraine) (Recent or Unexplained) Intracerebral Neoplasm Fixed Neurological Deficit Due to Any Cause Ophthalmological Visual Acuity Narrow Angle Glaucoma Any Acute Condition Ear / Nose / Throat Any Acute Disease Meniere’s and Other Vertiginous Conditions Orthopedic Musculoskeletal Integrity (Amputations, Malformations, Arthritides, Use of Appliances) Osteoporosis Cervical or Lower Spinal Cord Disease Diathesis for Pathological Fractures Acute Injury or Pain Genito-Urinary Calculi International Space University, MSS ‘05 impairment related to organic disease) (Evaluate for exception) (Evaluate for exception) (Legally blind) (Pain, Discomfort or Interference with ability to see) (Pain or Discomfort) (Treated and there is reasonable vertiginous-free period) (Structural and functional integrity preclude capability of emergency ground egress and use of life support systems) (Severe) (Significant) (Until Asymptomatic) (Evaluate for exception) 17 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases (Symptomatic) Chronic Renal Failure / Renal Insufficiency Pregnancy (including loss or termination of known pregnancy for any reason) Dysmenorrhea Acute Infection or Urinary Tract Obstruction Dermatology Any severe Skin Disease (Psoriasis, Chronic Pruritis, Skin Tumors) (Significant functional impairment) Bipolar Disease Suicide Attempt / Gesture Claustrophobia Substance Abuse / Dependence Miscellaneous Conditions (Phobias, Anxiety, Panic Attacks, Depression) Oncology Cancer Gastro-Intestinal Peptic Ulcer Disease Inflammatory Bowel Disease International Space University, MSS ‘05 (6 weeks post-partum) (Interferes with use of life support equipment) Psychiatry Any Psychotic Episode (Evaluate level of insufficiency) (Reversible Cause) (Evaluate for exception) (If there are no immediate means of relieving apprehension from confinement) (Ongoing) (History) (Evaluate history of stability) (Any active or treated cancer which interferes with function of any system or has the potential for incapacitation) (Evaluate for exception) (Symptomatic) (Symptomatic) (Asymptomatic) (Asymptomatic) 18 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases Irritable Bowel Syndrome Acute Pancreatitis Gall Bladder Disease Active Abdominal Pain, Nausea/Vomiting, Diarrhea of Any Etiology Hepatitis Cirrhosis Ostomies Abdominal Surgery (Symptomatic) (Symptomatic) Asthma Pneumothorax Pulmonary Function Miscellaneous Diabetes mellitus Infectious / Contagious Disease Anemia Medication Dental International Space University, MSS ‘05 (Asymptomatic) (Acute) (Until complete recovery) Pulmonary COPD (Chronic Obstructive Pulmonary Disease) (Asymptomatic) (Current or Recurrent) (Significantly decreased due to any cause) (Unstable, Brittle or Poorly Controlled) (Active) (Severe / Symptomatic) (Significant Side-Effects like Somnolence, Nausea / Vomiting or Exacerbation of Illness, if dosages are missed or poorly absorbed) (Significant Discomfort) (Evaluate for exception) (Evaluate for qualification) (Evaluate for exception) (Evaluate for exception) (Evaluate all others) (Evaluate all Type I Diabetics) (Blood-borne diseases like Hepatitis B & HIV/AIDS: Evaluate for qualification based upon risk of transmission) 19 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases 8 APPENDIX B Aspects of Space Tourist Safety Cardiovascular Neurological Medical Orthopedic Gastro-Intestinal Psychological Training Genito-Urinary Pulmonary Psychiatry Technical Space Tourist Safety Economic Ophthalmological Ear/Nose/Throat Dermatological Legal Oncology Miscellaneous Mission Design Risks International Space University, MSS ‘05 20 Taxi to the ISS – Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases Taxi to the ISS - Medical Guidelines for Space Tourists With Respect to Cardiovascular and Neurological Diseases Dr. Anis Karim Master of Science in Space Studies 2004-2005 International Space University Strasbourg, France International Space University, MSS ‘05 21