MEDICAL SURGICAL NURSING DEPARTMENT- FACULTY of NURSING- BENI-SUEF NATIONAL UNIVERSITY 2023-2024 Head of Medical surgical Nursing Department Dr/ Elsayed Sabek Program coordinator of Faculty of nursing, Beni Seuf National University Prepared by: Dr Walaa Eid Zaki ( Course coordinator) Lecturer, Medical Surgical Nursing. Faculty of nursing, Beni Suef University Dr Emad Abdel halim Lecturer, critical care and emergency Nursing. Faculty of nursing, Beni Suef University Dr Hamdya Ahmed Ali Lecturer, Critical care and emergency Nursing. Faculty of nursing, Beni Suef University Dr. Mona abdel aty Lecturer, Critical care and emergency Nursing. Faculty of nursing, Beni Suef University Assist.L/ Reda Quarany Assistant Lecturer, Critical care and emergency Nursing. Faculty of nursing, Beni Suef university Assist.L/ Walaa Nady Assistant Lecturer, Critical care and emergency Nursing. Faculty of nursing, Beni Suef university Assist.L/ Marwa Khaled Assistant Lecturer, Medical Surgical Nursing. Faculty of nursing, Beni Suef university Demo/Safia Kamel Demonstrator, Medical Surgical Nursing. Faculty of nursing, Beni Suef university Demo/Heba Ramdan Demonstrator, Medical Surgical Nursing. Faculty of nursing, Beni Suef university Demo/Sabreen Mahmoud Demonstrator, Medical Surgical Nursing. Faculty of nursing, Beni Suef university Demo/Fatma Ali Demonstrator, Medical Surgical Nursing. Faculty of nursing, Beni Suef university Demo/Abdelrahman Sayed Demonstrator, Medical Surgical Nursing. Faculty of nursing, Beni Suef university Demo/ Mahmoud hassan Demonstrator, Medical Surgical Nursing. Faculty of nursing, Beni Suef university 2 List of Content Content Nasogastric tube insertion Page 4 Nasogastric tube feeding 15 CVC insertion 29 CVP measurement 34 CVC sampling & Removal 42 ECG 48 Stress ECG 61 Holter 66 Hemodialysis care 68 Plasmapheresis 81 Portcath care 92 Extravasation care 107 References 116 3 Introduction The nurse should be familiar with the anatomy and physiology of the nose, pharynx, esophagus, and stomach when caring for clients with NG tubes. The nares are the exterior openings to the nasal cavity. Usually, one nare is larger and more patent than the other. The nasal floor is parallel to the roof of the mouth. The end of the nasal cavity is narrow and ends at the juncture of several bones, including a portion of the cribriform plate, which is a very thin bone that, if fractured, could provide a direct portal into the brain. For this reason, NG tube placement in clients with suspected head trauma may be contraindicated. The pharynx is a mucous membrane lined tube that begins at the nasal cavity and is divided into three major regions: the nasopharynx, the oropharynx, and the laryngopharynx. The epiglottis is a cartilaginous flap of connective tissue located at the entrance to the larynx. During swallowing, the larynx moves upward, and the epiglottis closes over the glottis to prevent aspiration of food and fluid into the trachea. The esophagus starts at the upper esophageal sphincter and runs down through the diaphragm past the lower esophageal sphincter to the stomach. Gastric intubation via the nasal passage (i.e. nasogastric route) is a common procedure that provides access to the stomach for diagnostic and therapeutic purposes. A nasogastric (NG) tube is used for the procedure. It is a long polyurethane or silicone tube that is passed through the nasal 4 passages via the esophagus into the stomach. The placement of an NG tube can be uncomfortable for the patient if the patient is not adequately prepared with anesthesia to the nasal passages and specific instructions on how to cooperate with the operator during the procedure. Polyurethane or silicone tubes are better for long-term use (> 4-8 weeks) because they are more flexible and less irritating to tissues. These tubes should be changed in line with the manufacturer’s guidelines (usually every 30-90 days). Polyvinylchloride (PVC) tubes should be used for a short period of time (3weeks) usually for gastric drainage, decompression, lavage or diagnostic procedures. Definition of NGT: Is a flexible plastic tube inserted through a nostril, down the posterior oro or nasopharynx, and into the stomach or the upper portion of the small intestine. It is typically used for decompression of the stomach or for administration of nutrition or medication to clients who are at risk for aspiration or unable to tolerate oral intake. Indications of NGT Insertion: A-Diagnostic Purpose – Evaluation of upper gastrointestinal (GI) bleeding (i.e. presence, volume). 5 – Aspiration of gastric fluid content. – Administration of radiographic contrast to the GI tract. B-Therapeutic Purpose – Gastric decompression, including maintenance of a decompressed state after endotracheal intubation. – Relief of symptoms and bowel rest in the setting of small-bowel obstruction – Dilute and remove a poison. – Aspiration of gastric content from recent ingestion of toxic material – Administration of medication – Feeding in malnourished patients – Administer fluids and other substances (e.g., activated charcoal, radiological contrast agents) when oral administration is not viable. Contraindications of NG tube insertion: There are two types of contraindications for any procedure or intervention and are referred to as absolute and relative. An absolute contraindication means the procedure or intervention may produce a life-threatening situation and should be avoided if possible. A relative contraindication means caution should be used because the possibility of an adverse event is possible; therefore, benefits must outweigh the risks. A- Absolute Contraindications – Severe maxillo – facial disorders, surgery or trauma (eg cribriform plate disruption), due to the possibility of inserting the tube intracranially. In this instance, an orogastric tube may be inserted. – Recent nasal, pharyngeal or esophageal surgery – Nasal CPAP – Patients with oropharyngeal tumor – Laryngectomy – Esophageal obstruction, such as a neoplasm or foreign object and esophageal tumors. B- Relative contraindications – Esophageal trauma, especially if caustic substances were ingested. – Coagulation abnormality or anticoagulation therapy may cause bleeding to the tissue from tube placement. – Esophageal varices or stricture – Recent banding or cautery of esophageal varice 6 Types of NG tubes 1-The Levin tube, the most commonly used NG tube for feeding and medication administration, has a single lumen, is typically 90–110 cm/35–43 in long, and they have a smaller bore with a size ranging from 8 to 12 French. 2-The Salem-sump, also called the gastric sump or ventral tube, It has two lumens: the smaller lumen (colored blue) is left open to the atmosphere for ventilation and the sump or larger lumen is used for suction or instillation of oral agents. The two-lumen design permits continuous suction because the smaller lumen vents the tube to atmospheric pressure to reduce the risk that a vacuum will form within the stomach and cause the NGT to adhere to the gastric mucosa. Their bore size ranges from 6 to 18 French, with those most commonly inserted being 14 to 16 French. 3-Dobhoff tube, is a special type of NG tube that is small bore and flexible, so it is more comfortable for the client than a standard NG tube. The tube is inserted with the use of a guide wire, called a stylet that is removed after correct tube placement is confirmed. A Dobhoff tube also has weight on the end to allow gravity and peristalsis to help advance the end of the tube past the pylorus, providing an additional barrier to reduce aspiration risk of nutrition or medications administered. 7 Rational Procedure steps Assessment Assess patient medical record for: Check the physician’s order for inserting a nasogastric tube. Patient name and age. Determine the purpose for the nasogastric tube. Diagnosis of patient. Medication of patient. History of previous esophageal and nasal surgery. Lab investigation e.g PT, PC and INR. Assess patient for: Presence of gag reflex by tongue depressor. Mental state or ability to cooperate with procedure. Preparation -Checking the order clarifies the procedure and type of equipment required. -To avoid mistake and determine size of NG tube according to patient age. -Facilitates outcomes. evaluation of -To save time and effort and Prepare Equipment: – Nasogastric tube of appropriate size. to ensure efficiency of the tube. Adult: 16-18F {1 French unit = 0.33 mm} – Water-soluble lubricant -Tongue blade – Flash light -Stethoscope – Non-allergic tape – Glass of water with ice chips (when person is conscious) . – Facial tissues – Suction machine – Bath towel or disposable pad – Emesis basin -Clamp – Drainage bag – Disposable gloves and PPE – Normal saline (for irrigation only) – Tommy syringe (irrigating syringe) – PH indicator strip -Oral hygiene supplies 8 Prepare Nurse. – Perform hand hygiene – Put on disposable gloves and PPE (if needed). -Reduce transmission of microorganisms. Prepare patient. -Ensures that the procedure -Check the patient’s identification. (Check client’s will performed on the correct patient. armband) - An explanation reduces -Explain the procedure, benefits, risks, complications, apprehension and facilitates and alternatives to the patient or the patient's cooperation. representative. -To enable the patient to stop the procedure if they wish. -Baseline data concerning the -Agree with the patient a signal by which he or she presence of bowel sounds and can indicate to stop the procedure e.g. by raising a the amount of distention will serve for future comparisons. hand. -obtain verbal consent from patient or relatives. -Assess the patient’s abdomen. -Because tearing may occur when the tube passes into nasopharynx. Removing dentures help prevent choking, -Ask patient to remove eye glasses and dentures if as it may result from losing or displacement of dentures. present. -Attempts to introduce a tube into an obstructed naris may cause discomfort and unnecessary trauma. -Check that the nostrils are patent by: a- For conscious: Asking the patient to sniff with one nostril closed. Repeat with the other side. For unconscious: Nasopharyngeal suction if needed. b- Examine naris with pen light for obstruction of deformities as deviated septum or nasal polyps” Prepare environment. -Close curtains around the bed and close the door to -Demonstrates respect for the room, if possible. dignity. -Maintain bed at high comfortable position at waist level to ensure good body mechanics. 9 Implementation -Place a suction machine at the bedside if the patient -Provides a method for is unresponsive or has difficulty swallowing. clearing the patient’s airway of vomitus. -Assist the patient to high fowler’s position, at least a - An upright position is more 45° angle or higher. Place comatose clients in semi- natural for swallowing and Fowler’s position. Note: The head should not be tilted protects against aspiration. backwards or forwards.. - Monitor pulse oximeter and capnograph before, Provides baseline for objective during and after procedure. assessment of respiratory If patient has increase in end-tidal carbon dioxide or status during tube insertion. decrease in oxygen saturation, tube should not be inserted until you determine patient stability. -Drape patient chest with a bath towel or disposable - The patient might vomit as pad and have an emesis basin at bed side patients bed. passage of the tube may stimulate gagging. -Using a small piece of tape, mark the distance which -To identify the length of tube the tube is to be passed by measuring the distance on that needs to be inserted to the tube from the patient’s bridge of the nose to ear ensure it is in the correct lobe from the ear lobe to the bottom of the position. xiphisternum (NEX measurement). -Using water-soluble lubricant and lubricate about 2- -If aspirated; water-soluble 3inches (5-7.5 cm) of the tube with a thin coat of lubricant does not cause lubricating jell that has been placed on gauze swab. pneumonia, and lubricant prevents damage to mucosa during insertion. . Pinch ending of NGT during insertion (If patient -Iced tube becomes stiff and vomitus Open tube on draindge bag or emesis basen). inflexible and causing trauma Note: Do not ice tubes. to nasal mucosa. 10 -Hold tube about 10cm from the tip and insert it into nostril gently guiding it straight back and downward along floor of nose with a twisting movement of tube in fingers until resistance is met. Note: If an obstruction is felt, withdraw the tube and try again in a slightly different direction or use the other nostril. -At this point, ask the patient to start swallowing. An assistant may be required to help give the fluids if the patient is unable to take it. Note: if the patient is comatose, absent gag reflex or un -cooperate, do not attempt to use water orally to pass tube. Neck positioning may facilitate passage (flex head toward chest). -Continue to advance tube gently each time patient swallows until you reach point on tube previously marked with tape. - Helps tube follow path of nasal passage. -Check for position of tube in back of throat with penlight and tongue blade. -Tube may be coiled, kinked, or inserted into trachea. -If patient is gasping, cyanotic, or unable to speak, stop procedure, remove the tube immediately, let patient relax, re-lubricate tube, then reinsert. -Secure tube to patient’s nose with tape. Make sure the skin on the person’s nose is clean and dry. Cut a 3 to 4 inch strip of tape and cut it up the center 1 to 1.5 or 2 inches. Place the solid portion on the nose and wrap the ends tightly around the tube. -Tube may have entered trachea instead of esophagus. -To avoid unnecessary trauma to the nose and nasopharynx. -The swallowing action places the epiglottis over the trachea allowing the tube to enter the esophagus. -To ensure that tube reach the stomach. -Taping the tube to the nose helps to keep it from slipping out or being pulled out. Dry, clean skin facilitates adhesion of the tape to the nose. - Check placement of tube in stomach by using the following methods: 1. Traditional method: (Not reliable alone but Consider that: more available) - If air is difficult to hear, Instill 20-30 mL of air into the tube with the tube may not be in the 11 a large syringe while listening for the air stomach. bolus over the epigastric region. - If the injected air is audible in the mouth area, the tube tip may have curled in the upper Gl tract. - If unable to instill air, the tube may be kinked. (AACN, 8th ed , 2024) Indicator strips can 2. Advanced methods: ( more reliable and distinguish between gastric accurate) acid and bronchial secretion (pH<6) A- Use syringe to gently aspirate stomach contents -Do not inject an air bolus, as and testing 2 ml of stomach contents with pH the best practice is to test the indicator strips. A pH of between 1 and 5.5 is pH of the aspirated contents to reliable confirmation that the tube is not in the ensure that the contents are lung. acidic. B- Chest or upper abdomen X-ray to confirm position. -According to purpose of insertion: Either attach tube to suction or drainage bag or clamp or plug it, begins lavage/ irrigation, instill medications, or begin gastric gavage. -Connecting the tube depends on the purpose for which the tube was inserted. Also, If tube is left open, gastric content may drain into gown or linens. Post care Patient: -Clean the tube of any remaining lubricant and provide oral hygiene at least twice daily. -Oral hygiene and cleansing promote the patient’s comfort, sense of wellbeing and remove microorganism. -Keep the patient comfortable “with a minimum head - Position the patient with a elevation of 30 degree. minimum head elevation of 30 degree, to prevent gastric reflux. 12 Equipment. - Dispose of rubbish appropriately; rinse the - Rinsing promotes cleanness. equipment if it will be reused. Nurse - Hand washing deters the spread of microorganisms. -Remove gloves and PPE& hand washing. Environment -rearrange of environment. Documentation -Document the following: Date and time of procedure Size and type of tube inserted Length of tube extending from nostril How tube position confirmed. Document and report any abnormalities as needed Measure and record the volume of drainage (if any) at least every 8 hours. Signature Documentation provides coordination of care. Communicates to the other members of the health care team and contributes to the legal record by documenting the care given to the patient. Also, provides data for evaluating fluid balance. Routine Nursing Care for Patient with NG Tube Patient with NG tubes are at constant risk for developing adverse effects. While caring for patient with NG tube, nurses monitor risks and adopt strategies for patient safety and quality of care. The nurse should perform the following interventions: o Keep the head of the bed 30 degrees or higher. Patients with NG tubes are at risk for aspiration, especially if they are receiving enteral nutrition. The head of the bed should always be raised 30 degrees or higher to prevent aspiration. 13 o Prevent migration and/or dislodgement of the tube. The NG tube should be fastened to the patient using a securement device and taped/pinned to the patient’s gown to prevent the tube from slipping from out of the stomach, migrating into the lungs, or being accidentally removed. – Daily assessment of patency of the tube, location, accuracy. – Inspection of the nares for irritation. If so remove it and replace in the opposite nares, daily cleansing using swab moistened with water around the entrance of the tube is recommended to remove secretions. – Inspect the adhesive tape for irritation of the underlying skin. – Frequent oral hygiene. Apply cream for lips if they were cracked. – Accurate record of intake and output, daily weighting. – Minimize discomfort: a. Generous lubrication, the use of topical anesthetic, and a gentle technique may reduce the patient’s level of discomfort. b. Throat irritation may be reduced with administration of anesthetic lozenges (eg, benzocaine lozenges [Cepacol]) prior to the procedure. – Epistaxis may be prevented by generously lubricating the tube tip and using a gentle technique. o Monitor for potential complications. Signs of tube dislodgement into the respiratory tract include coughing, shortness of breath, adventitious lung sounds, or decreasing oxygen saturation levels. Signs of esophageal perforation include neck or chest pain, dysphagia, dyspnea, subcutaneous emphysema, or hematemesis. Common complications A- Minor Complications - Nasal irritation. - Epistaxis. - Sinusitis. 14 B- Severe Complications –Inadvertent placement in the trachea (Pulmonary intubation) leading to pleural injury, pneumothorax, tracheobronchial aspiration, pneumonia, and death if fluids or other agents are infused. –Esophageal perforation. –Inadvertent intracranial placement through a fractured cribriform plate. – Trauma to the nares or larynx, esophagus, and/or stomach during insertion. – Trauma or erosion of gastric mucosa, which is more common if gastric suctioning is prolonged. Definition of NGT Feeding: Gavage is artificial method of giving persons fluids and nutrients through a tube inserted to the stomach when oral intake is inadequate or impossible. Purposes: A nasogastric gavage feeding is administered to: o Provide total or supplemental nutrition. o Restore fluid, electrolyte, and acid-base balance. Indications of Gastric Gavage Inability to ingest adequate nutrient orally e.g certain neurologic disorders (stroke) Hyper metabolic states (burns, multiple trauma, sepsis and cancer). Following certain types of surgery (head and neck, esophaus) Decrease level of consciousness (coma). Malnutrition. Endotracheal intubation. Contraindication of Gastric Gavage Absent bowel sounds Advantages of Tube Feeding: 15 Tube feedings have several advantages 1-They are low in cost and safe 2-usually well tolerated by the patient 3- easy to use both in extended care facilities and in the patient’s home. 4-May be continued for weeks without any danger to the patient Remember the abbreviation NG TUBE before feeding Complications of Tube Feeding:A-Gastrointestinal Complications: *Diarrhea *Nausea and Vomiting B-Mechanical Complications: *Aspiration Pneumonia *Tube displacement or obstruction *Nasopharyngeal irritation C-Metabolic Complications: *Hyper/hypoglycemia . *hypokalemia (low potassium). *Dehydration or over hydration D-Others *Constipation *Cramping and Distention Sinus infection Nose bleeding 16 Rational Procedure steps Assessment Assess patient medical record for: Physician order. Time, amount and type of ordered formula. Medications to be administered before, during and after feeding. Type, amount of last feeding. Assess patient for: Assess patient’s height, weight, hydration status, electrolyte balance, caloric needs and intake and output (I&O) Assess abdomen by inspecting for presence of distention, auscultating for bowel sounds. If patient connected with ETT, maintain cuff inflated Assess Formula for Expiration date of feeding formula. Be sure at room temperature -Reading the written order ensures that the procedure will comply with the directives of the physician. - Checking ensures that correct feeding will be administered and outdated formula may be contaminated. -Provides baseline information to measure nutritional improvement after enteral feedings. -To assess GIT motility. Preparation Prepare equipment: – Formula. – Tommy syringe, feeding bag. – Clamp & rubber band. – Disposable pad or towel. – Water. – Clean Gloves. – Enteral feeding pump-if ordered. -To save time and effort – Stethoscope. Prepare myself. – Perform hand hygiene and put on disposable gloves. Prepare patient. – Identify the client. – Explain the procedure and its purpose. -Reduce transmission of microorganisms. - Ensures that the procedure will be performed on the correct patient. 17 -Position the patient with head elevated at least 30 to45 degrees or normal position for eating as possible. N.B, If patient is forced to lay supine, reverse Trendelenburg position. -To gain patient cooperation and of bed reduce anxiety. as near - Gravity promotes the distribution of food to the lower place in level of the stomach & minimizes the risk of aspiration. -Place protective drape over patient chest. -To prevent patient clothes and linen from being wet. Prepare environment. -Close curtains around the bed and close the door -Demonstrates respect for dignity. to the room, if possible. -Maintain bed at high comfortable position at waist level to ensure good body mechanics. Implementation -Check the placement of gastric tube through using pH indicator strip to test the pH (pH should be 1-5.5). To prevent accidental instillation into the respiratory tract if the tube has become dislodged. - Aspirate stomach contents to determine amount of residual and calculate the amount aspirated in relation to the amount of previous last feeding, if it is 50% or more from the last amount, return it again to the stomach and wait for one hour and repeat aspiration again, if the same amount aspirated report to the doctor. - Pinch the tubing. -To prevent electrolyte imbalance. - Gastric aspiration content returning again because it is mixed with gastric enzymes and secretion essential for digestion. -When using Toomey syringe: -To promote infusion of formula along tubing. -Remove plunger from barrel of syringe and attach barrel to nasogastric tube. - Elevate syringe to 18 inches above the patient's head. - Fill syringe with formula and allow syringe to empty gradually. Refilling until prescribed 18 - This procedure prevents air from entering stomach. -Graduals emptying of tube feeding by gravity from syringe or gavage bag and reduce risk of diarrhea. amount has been delivered to the patient. When using feeding bag: - Attach bag to the end of the feeding tube and raise bag 18 inches above patient's head, fill bag with prescribed amount of formula and allow bag to empty gradually. -Follow tube feeding with water in amount ordered then clamp the proximal end of the tube feeding. -Provides patient with source of water to help maintain fluid and electrolyte balance. -Label feeding bag with date and time, change the bag and set every 12 to 24 hours. -Observe patient response during and after tube feeding. Pain may indicate stomach distension which may lead to vomiting. Post care Patient: - Keep the head of the bed elevated for at least 30 - To prevent gastric reflux and aspiration. to 60 minutes after a feeding. - Provide oral hygiene at least twice daily. -Remove microorganisms and promotes comfort and hygiene of the patient. Equipment. - Dispose of rubbish appropriately; rinse the equipment if it will be reused. - Rinsing promotes cleanness and prepares the equipment for the next feeding. Nurse -Remove gloves and PPE& hand washing. - Hand washing deters the spread of microorganisms. Environment -rearrange of environment. 19 Documentation Date, time & amount of feeding formula. Amount of water used to flush the feeding A written summary facilitates the documentation of the procedure & provides a record of comprehensive care. tube. Amount of gastric residual. Any drugs instilled through the tube. Unexpected outcomes. Nurse signature. Nursing Considerations for patients with NGT feeding: 1-If the patient has endotracheal tube; the cuff inflation should be confirmed before feeding to avoid aspiration. 2-Monitor blood glucose level frequently as high carbohydrate concentration of formula may exceed endogenous insulin supply and cause hyperglycemia. 3-Weight the patient daily and compare with base line weight to avoid weight loss or gain. 4-Auscultate the patient’s bowel sound frequently. Definitions: Gastrointestinal decompression: Is a process of reliving pressure by removing accumulated gas and secretions from gastrointestinal tract through nasogastric tube. Gastric lavage: Also commonly called stomach pumping or gastric irrigation, is the process of cleaning out the contents of the stomach. Indications: 1. Determine patency of NG tube. 2. Maintain patency of NG tube. 20 3. Wash stomach of toxic substances in poisoning treatment. 4. They may also be used in diagnosis and stop gastric hemorrhage. 5. To clean stomach before diagnostic procedures and to empty the stomach after endoscopic procedure. Contraindication: Lavage is contraindicated when patients have a compromised, unprotected airway and in patients at risk of gastrointestinal hemorrhage or perforation. Relative contraindications include when the poisoning is due to a corrosive substance (strong acids). Steps Rational Assessment Assess patient medical record for: Physician order. Indication of gastric lavage. Medications to be administered with lavage fluid. Reading the written order ensures that Type, amount and temperature of gastric the procedure will comply with the lavage. directives of the physician. Need for sample of gastric aspirate. Assess patient for: Vital signs LOC Preparation Prepare equipment: – Container for irrigation solution – Nasogastric tube connected to continuous or intermittent suction – Irrigating syringe – Protective drape – Urinary bag To save time and effort. – Clean gloves – Irrigation solution ''saline or water'' –Stethoscope – Graduated container –Container for gastric content sample 21 Prepare myself. – Perform hand hygiene and put on disposable gloves and PPE (if needed). -Reduce transmission of microorganisms. Prepare patient. – Identify the client. - Ensures that the procedure will be performed to the correct patient. – Explain the procedure and its purpose. -To gain patient cooperation and reduce anxiety. – Assess abdomen by inspecting for presence of distention, auscultating for bowel sounds. - Gravity promotes the distribution of fluid to the lower level of the stomach & minimizes the risk of aspiration. -To prevent patient clothes and linen from being wet. – Assist the patient to a semi-fowler’s position unless this is contraindicated. – Place protective drape over patient chest. Prepare environment. -Close curtains around the bed and close the Demonstrates respect for dignity. door to the room, if possible. -Maintain bed at high comfortable position at waist level to ensure good body mechanics. Implementation -If patient connected with continuous. Clamp the suction tubing near the -Clamping protects the patient from leakage of gastric drainage. connection site. Disconnect the nasogastric tube from the suction unit and place it over drape. -Check the placement of gastric tube through using pH indicator strip to test the pH (pH should be 5.5 or less). -To prevent accidental instillation into the respiratory tract if the tube has become dislodged. 22 -Pour irrigating solution into a container. -Measuring the amount ensures that the precise amount is delivered through the tube. Using saline compensates for electrolytes lost through nasogastric drainage. - Pinch the tubing. - This procedure prevents air from entering stomach. -Remove plunger from barrel of syringe -To promote infusion of formula along and attach barrel to nasogastric tube. tubing. - Elevate syringe to 18 inches above the patient's head. -Graduals emptying of tube feeding by gravity from syringe or gavage bag and reduce risk of diarrhea. - Fill syringe with formula and allow syringe to empty gradually. Refilling until prescribed amount has been delivered to the patient. - If unable to irrigate. reposition the patient and attempt irrigation again after check with physician - Reconnect tube with suction or drainage bag according to prescription - Measure and record the amount and description of the irrigation and returned solution. Post care Patient. -return patient to comfort position. Equipment. - Dispose of rubbish appropriately; -To maintain patient comfort. - Rinsing promotes cleanness and prepares the equipment for the next irrigation. rinse the equipment if it will be reused. 23 Nurse -Remove gloves and PPE (if used) & - Hand washing deters the spread of microorganisms. hand washing. Environment -Rearrange environment. Documentation Record & report : Date, time & reason of gastric lavage. Type and amount solution. of -A written summary facilitates the irrigating documentation of the procedure & provides a record of comprehensive care. Color, amount and consistency of drainage. Any drugs instilled through the tube. Unexpected outcomes. Nurse signature Removal of Nasogastric tube When the NG tube is no longer necessary for treatment, the primary care provider will order the tube to be removed. The NG tube is removed as carefully as it was inserted to provide as much comfort as possible for the patient and to prevent complications. Procedure of NGT Removal:` 24 Assessment Reading the written order and ensure that the procedure will comply with the directives of the physician. Assess patient medical record for: Physician order. Assess patient for: Absence of indications of tube insertion. Vital signs. Preparation Prepare equipment: • Tissues • 50-mL syringe • Non-sterile gloves • Additional PPE, as indicated • Stethoscope • Disposable plastic bag • Bath towel or disposable pad • Normal saline solution for irrigation (optional) • Emesis basin To save time and effort. Prepare myself. – Perform hand hygiene and put on disposable gloves and PPE (if needed). -Reduce transmission of microorganisms. Prepare patient. – Identify the client. - Ensures that the procedure will be performed on the correct patient. – Explain the procedure and its purpose. -To gain patient cooperation and reduce anxiety. – Assess abdomen by inspecting for presence of distention, auscultating for bowel sounds. – Assist the patient to a semi-fowler’s position unless this is contraindicated. – Place protective drape over patient chest and give paper tissues to patient. 25 - minimizes the risk of aspiration. -To prevent patient clothes and linen from being wet and avoid contact with gastric secretion. To blow nose when tube is removed Prepare environment. -Close curtains around the bed and close the -Demonstrates respect for dignity. door to the room, if possible. -Maintain bed at high comfortable position at waist level to ensure good body mechanics. Implementation -auscultate abdomen for presence of bowel sound -Verifies return of peristalsis -Discontinue suction and separate tube from suction and carefully remove adhesive tape from patient's nose. - allow for its unrestricted removal of tube - Attach syringe and flush with 10 mL normal saline solution . - Saline solution clears the tube of secretions, feeding, or debris. - Instruct patient to take a deep breath and hold -To prevent accidental aspiration of it. gastric secretions in tube. Careful removal minimizes trauma and discomfort for patient. -Clamp tube with fingers by doubling tube on -Clamping prevents drainage of itself. Quickly and carefully remove tube while gastric contents into the pharynx and patient holds breath. esophagus. Post care Patient -return patient to comfort position. - perform mouth care to patient and provide paper tissues to blow nose. -Continue to monitor patient for 2 to 4 hours after tube removal for gastric distention, nausea, or vomiting. Equipment 26 -To maintain patient comfort. - Place tube in disposable plastic bag. Nurse -Remove gloves& hand washing. -Hand washing deters the spread of microorganisms. Environment -Rearrange environment. Documentation Record & report : Date, time A written summary facilitates the documentation of the procedure & provides a record of comprehensive care. Unexpected outcomes Patient tolerance Nurse Signature 27 Central Venous Catheter (CVC) maneuver Outlines: Central venous catheter insertion: Indication Contraindication Procedures for insertion Complication Central venous pressure monitoring: Monitoring by water manometer Monitoring by transducer Blood sampling from CVC Dressing change Removing of CVC 28 CVC insertion Introduction:Central venous catheters (CVCs) are a commonly used modality throughout the medical center and especially in the intensive care units, serving vital role in the management of critically ill patients. Definition of CVC:Central venous catheter (CVC), also known as a central venous line (CVL), or central venous access (CVA). It is a long, thin, flexible tube placed into a large (central) vein in the neck, upper chest or groin. This type of catheter has special benefits in that it can deliver fluids into a larger vein for a longer period of time, usually several weeks or more. 29 Indication of CVC insertion: Vascular Access: Emergency venous access and failure of peripheral access. As an alternative for repetitive venous cannulation of chronically ill patients or patients with small thrombosed, or difficult to find veins. Long term IV access anticipated. Provision of Medications or Solutions: Drug infusions that could otherwise cause phlebitis or sclerosis (e.g., vasopressors and hyperosmolar solutions) - Central venous pressure (CVP) monitoring. - Volume loading: Fluid resuscitation (including blood products). Repeated Blood Sampling: Although not an indication we usually consider, the ability to draw blood samples from a central line will negate multiple needle pokes for the patient who needs frequent blood sampling. Introduction of Pacemakers or Pulmonary Artery Catheters: For urgent and short term hemodialysis. Relative contraindications of CVC insertion: 1. Bleeding disorders or current anticoagulation or thrombolytic therapy. 2. Distortion of local anatomy or landmarks. 3. Vasculitis, cellulitis, burn, severe dermatitis or other infection over the anticipated insertion site. 4. Suspected acute or prior injury to the vein. 5. Pneumothorax or hemothorax. 6. Morbid or marked obesity. 7. Mastectomy on the side of insertion. 30 Sites of CVC insertion Procedure of CVC Insertion:a- Equipment. b- Procedure. Post-Catheter Placement. Equipment Facilities to monitor the patient – particularly ECG Central venous catheter kit. Sterile gloves (appropriate size). Sterile gown proline suture (Size 3.0) large dressing pack 2 x10ml syringes 2 x 5ml syringe Local anesthetic (2% Lidocaine) Antiseptic solution (0.5% Chlorhexidine in Alcohol 70%) 10ml 0.9% Sodium chloride for injection 18G and 23G needles Rolled towel or sandbag. 31 o o o o o o o o o o o o Procedure of insertion: Explain procedure to the patient. Ensure ECG, BP and SaO2 are monitored. The physician will do scrubbing and wear gown and glove. Position the patient – supine with head slightly down. Turn the head away from selected site if requested, place a rolled towel or sandbag vertically between scapulae and provide gentle traction on the arm (in the case of a subclavian approach). The skin is prepared with 0.5% Chlorhexidine in Alcohol 70% and draped. Local anaesthetic is administered. The central venous catheter is inserted into the superior vena cava using a sterile Technique. Blood is drawn back through the catheter and each lumen is flushed with saline. The catheter flange is sutured into position on the skin. The site is cleaned and an occlusive dressing applied. Check the position of the line on X-ray prior to the infusion of fluids. Ensure that nursing documentation is completed. Post-Catheter Placement Aspirate blood from each port Secure catheter with sutures Dispose all sharps. 32 Place an occlusive sterile dressing. Flush lumens with saline to maintain patency. Obtain a chest x-ray (for correct placement checking). Monitor site for bleeding. Assess vital signs and breathe sounds. Document insertion, site, dressing and flushing. Potential complications of CVC Insertion: Hemorrhage: Catheter occlusion: by a blood clot or kinked tube - regular flushing of the CVC line and a well secured dressing should help to avoid this. Infection Air embolus. Catheter displacement Others important Complications of CVC insertion Venous thrombosis Arterial puncture Pneumothorax and hemothorax Cardiac tamponade Tracheal injury Nerve injury pulmonary embolism Cardiac dysrhythmia Special considerations: Arrange for daily chest X-rays as ordered to check catheter placement. Change the dressing every 24 to 48 hrs or according to agency policy. After insertion, watch for signs and symptoms of pneumothorax, such as shortness of breath, uneven chest movement, tachycardia, 33 and chest pain. Notify the practitioner immediately if such signs and symptoms appear. Use sterile technique when performing dressing, tubing, and solution changes for a central venous access catheter. (See “Changing the dressing on a central venous access catheter,” Assess the site for signs and symptoms of infection, such as discharge, inflammation, and tenderness. To prevent an air embolism, close the catheter clamp, or have the patient perform the Valsalva maneuver or exhale each time the catheter hub is open to air. Routinely evaluate catheter necessity and discontinue catheter use as soon as it’s no longer needed to reduce the risk of vascular catheter-associated infection. Routinely flush the access device after blood sampling, before and after medication administration, with discontinuation of an infusion, and when the catheter isn’t in use. CVP Measurment Central Venous Pressure (CVP) Definition: It is the pressure of blood in the thoracic vena cava (right atrium) .It reflects the amount of blood return to the heart and the ability of the heart to pump the blood to the arterial system. Normal CVP reading is in midaxillary line (2:6 mmhg or 5:10cmH2O) Ideally, pressure should be measured from the distal (tip) lumen, with no other infusions running through that lumen, but when distal lumens are unavailable, differences from other lumens are usually insignificant. 34 Purposes of CVP measurement To assess patient’s fluid volume status To assess preload of the heart Provide information about the right ventricular function and right side hemodynamics Evaluation of patient response to therapy. CVP Recording Phlebostatic axis CVP is usually recorded at the mid-axillary line where the manometer arm or transducer is level with the phlebostatic axis. This is where the fourth (4th) intercostal space and mid-axillary line cross each other allowing the measurement to be as close to the right atrium as possible. Methods of CVP monitoring:CVP is measured using an indwelling central venous catheter and a pressure manometer or transducer. CVP measurement using a manometer Steps Rationale Assessment: Patient's medical record: a. Physician order b. Diagnosis c. Client's medications, and treatments d. Last CVP reading e. Last feeding time b-To identify condition that increase or decrease CVP reading. d-To obtain base line data e-To prevent aspiration 35 Patient : a- Cardiopulmonary status a. Assess base line data b-Assess factors that increase risk of aspiration as: - Cuff inflation (for patient with ETT or TT) - Ability to lie at supine position - Level of consciousness b. Deflated cuff increase risk of aspiration Machine if present as: c- Mechanical ventilator for PEEP level (if patient connected with MV) d- Syringe Pump or Infusion Pump. c. To identify factor that affect CVP reading (High PEEP increase intra thoracic pressure that increase CVP reading) d. All infusion must be temporally stopped during measurement except certain infusion as (Intropics). Preparation: To save time and effort A-For equipment : (Prepare necessary equipment) IV solution (normal saline) Two IV infusion set IV pole Water manometer Disposable gloves. Two different syringes. Three way stopcock B-For self To minimize risk of infection. 1. Hand washing. 2. Put on disposable gloves To maintain patient privacy. C- For environment -Close doors, windows and pull curtains. D- For patient To ensure correct patient. To gain patient cooperation and to decrease fear and anxiety. 1. Identify patient using two identifiers. 2. Explain procedure to the patient. 3. Implementation: Connect three way stopcock to the distal lumen (if present) of 36 To prevent air embolism CVC. Connect infusion to IV line and expel air. Connect IV solution to the three way of the catheter. Open the three way between IV line solution and the patient. Allow the normal saline to drip rapidly for few second. For accurate measurement To ensure patency of CVC To confirm placement of CVC Perform flush back. Turn the three way stopcock off to the patient. Attach the water manometer and open the three way between infusion and manometer until air completely removed from manometer then turn off. Place patient in supine position unless contraindicated (if not possible place patient in semi sitting position from 0 to 45 degree) Locate the zero point in the patient chest (fourth intercostal space at the mid-axillary line). Turn off any additional lines and pumps (Unless contraindicated) given via the same lumen that the manometer is attached to. Open the three way between water manometer and patient. 37 To avoid risk of air embolism. To evacuate air from manometer. To ensure base line of the manometer at the same level to the right atrium At the same level to the right atrium To ensure a closed system between the manometer and the right atrium To allow fluid to drip from the manometer to the right atrium Watch for fluid falls at the manometer until fluctuation occurs and take measurement at the end of expiration. To minimize the effect of intrathoracic pressure 4. Post care: For patient Return the patient to the comfortable position. Disconnect the water manometer and IV solution. Reconnect infusions at preset rate (if stopped during measurement). To provide comfort and to avoid respiratory distress For equipment Cover the ports of three way stopcock, water manometer and IV set. Discard disposable equipment. For environment Open doors, windows and remove curtains. For self Remove gloves and hand washing. To minimize risk of infection. 5. Documentation: Date and time. Reading of CVP. PEEP level(if patient connected with MV) Any complications that appear during procedure. Position of patient during procedures Signature. 38 Measuring CVP using a transducer Transducer system setup 39 Steps Make sure that the patient is attached to a cardiac monitor with pressure monitoring capability. Make sure that the alarm limits are set appropriately for the patient’s current condition and that the alarms are turned on, functioning properly, and audible to staff. If the patient has a CV catheter with multiple lumens, the distal port is dedicated to continuous CVP monitoring. Setup transducer system The CVC will be attached to intravenous fluid within a pressure bag. Ensure that the pressure bag is inflated up to 300mmHg. (Prevents catheter from clotting by allowing 3-4 ml/hr flush solution to be delivered through the catheter. Label the tubing at the distal end (near the patient connection) and at the proximal end (near the source container) to reduce the risk of misconnection if multiple IV lines will be in use. Place the patient flat in a supine position if possible. Alternatively, measurements can be taken with the patient in a semi-recumbent position. The position should remain the same for each measurement taken to ensure an accurate comparable result Tape the transducer to the phlebostatic axis or as near to the right atrium as possible. (Mark the appropriate place on the patient’s chest so that all subsequent measurements use the same location). Turn the stopcock next to the transducer off to the patient and open to air. Remove the cap to the stopcock port. 40 Press the zero button on the monitor and wait while calibration occurs. When 'zeroed' is displayed on the monitor, replace the cap on the three-way tap and turn on to the patient. Place a new sterile, non-vented cap on the stopcock to maintain sterility. Perform a square waveform test (dynamic response test) to verify the accuracy of the pressure monitoring system. Read the CVP value by measuring the mean of the wave at end-expiration. The monitor will also provide a value on the digital display(blue line in this image) (The waveform undulates as the right atrium contracts and relaxes, emptying and filling with blood) Return the bed to the lowest position to prevent falls and maintain patient safety. Remove and discard your gloves and other personal protective equipment if worn. Perform hand hygiene. Document the procedure. Factors that affect CVP:o Factors that increase CVP : Cardiac tamponade • Decreased cardiac output Forced exhalation • Heart failure • Pleural effusion Hypervolemia Pulmonary Embolism •Pulmonary Hypertension 41 Mechanical ventilation •Tension pneumothorax Application of positive end-expiratory pressure (PEEP). B- Factors that decrease CVP : Deep inhalation Hypovolemia Blood Sample aspiration from CVC Definition: It is the aspiration of blood sample from CVC by using the syringe. Blood sampling the use of strict sterile no-touch technique is necessary to reduce the risk of vascular catheter–associated bloodstream infection. In addition, CVC blood sampling should not be performed using the same catheter lumen that is used for drug infusions. Only the minimal amount of discard blood should be obtained to help prevent nosocomial anemia. Equipment: - Non sterile gloves - Blood tubes and /or blood culture bottles for required tests. - Alcohol swab - Two syringes (10 ml) - Specimen tubes. - 10mls of sodium chloride 0.9% (Normal saline) - Sterile gauze and dressing. Steps: 1-Prepare equipment 2-Prepare myself (hands washing and wear non-sterile gloves). 3- Identify the patient and explain the procedure to the patient. 4-Stop any infusion running through CVC (don't stop emergency drugs). 5- Use the largest lumen (usually distal) of multi-lumen CVCs whenever possible. 42 6- Close clamp between CVC and infusions. 7- Disconnect the tubing from the injection cap. 8- Disinfect the injection port with alcohol swab 9- Attach 10 ml syringe in to CVC catheter port 10- Open clamp on CVC and gently withdraw 10 ml blood from CVC 11- Clamp CVC and remove syringe. 12- Connect another 10 ml syringe and open the clamp between syringe and CVC. 13- Aspirate desired amount of blood for lab investigation 14-Return blood aspirated firstly. (Check for blood clot before returning, if present, discard it). 15- Attach syringe containing 0.9% sodium chloride to the closed port of CVC. 16-Open the clamp and flush CVC with 0.9% sodium chloride. 17- Clamp CVC, reconnect the infusion. 18- Open the clamp between CVC and infusion 19- Fill blood tubes with appropriate quantity of blood 20- Label tube with patients name, unit, and type of the test. Flushing and locking Aspirating for a blood return and flushing a CVC is a routine step to assess catheter patency before each infusion, prevent mixing incompatible medications and solutions after infusion, and prevent catheter occlusion after blood sampling. Locking is performed after the final flush to maintain patency and prevent occlusion in a device that’s used intermittently. If the system is used intermittently, the flushing and locking procedure will vary by facility preference, the medication administration schedule, and the type and size of the catheter. Catheter must be regularly flushed. To maintain patency in catheters used intermittently, facilities may use a heparin flush solution available in prefilled syringes of 10 units of heparin per milliliter or preservative-free 43 normal saline to lock the catheter. (According to patient condition and facility policy). Changing the dressing on a central venous access catheter Despite the various designs and applications of central venous access devices, certain aspects of dressing changes apply to all device types. The sterility and integrity of the device must be maintained at all times to reduce the risk of vascular catheter–associated infection. Transparent semipermeable dressings should be changed every 5 to 7 days, and gauze dressings should be changed every 2 days. If signs and symptoms of infection are present, or if the dressing becomes visibly soiled, loosened, or dislodged, change the dressing immediately to closely assess, clean, and disinfect the site Equipment for dressing and removal: - Dressing pack - Sterile scissors (if tip of CVC required for microbiology) - Sterile container (if required for CVC tip) - Stitch cutter and forceps -Non sterile gloves -Adhesive tape. -Sterile gloves - Disinfectant solution (Chlorhexidine) 44 Steps: Determine the date of the last dressing change. Perform hand hygiene. Assemble the supplies on a sterile field. Put on gloves to comply with standard precautions. Remove the existing dressing by lifting the edge of the dressing at the catheter hub and gently pulling the dressing perpendicular to the skin toward the insertion site to prevent catheter dislodgment and tearing or stripping of fragile skin. If necessary, use a non-acetone adhesive remover to remove adhesive from the patient’s skin, because a product containing acetone can harm the catheter. Discard the dressing in an appropriate receptacle. If a chlorhexidine-impregnated sponge dressing was used to provide sustained antimicrobial action at the insertion site, remove and discard it in an appropriate receptacle. Remove the engineered stabilization device and discard it in the appropriate receptacle. Assess the catheter–skin junction and surrounding skin for bleeding, redness, swelling, tenderness, induration, and drainage. Inspect the catheter for cracks, leakage, kinking or pinching, and mechanical problems. Remove and discard your gloves. Perform hand hygiene. Put on sterile gloves. Measure the external catheter length using a sterile tape measure to make sure that the catheter hasn’t migrated. 45 Clean the catheter insertion site with chlorhexidine to provide skin antisepsis; if the patient is sensitive to chlorhexidine, use tincture of iodine, povidone-iodine, or alcohol swabs. Allow the area to air-dry completely. If povidone-iodine solution is used, apply it using swabs. Begin at the catheter insertion site and move outward in concentric circles. Allow the solution to remain on the skin until it dries completely (for at least 2 minutes). Apply a skin barrier solution according to the manufacturer’s instructions to reduce the risk of medical adhesive–related skin injury. Don’t use compound tincture of benzoin, because it may increase the bonding of adhesives to the skin, causing skin injury when the adhesive-based engineered stabilization device is removed. Stabilize and secure the catheter, using an engineered stabilization device, if available; stabilization device an is engineered recommended because it reduces the risk of unintentional catheter dislodgment If applicable, place a chlorhexidine- impregnated sponge dressing at the catheter base. To facilitate future removal, position the chlorhexidine-impregnated sponge dressing with the catheter resting on or near the radial slit of the dressing. The edges of the slit must touch to maximize antimicrobial action. NURSING ALERT Use chlorhexidine-impregnated dressings with caution in premature neonates and in patients with fragile skin or complicated skin pathologies, because contact dermatitis and pressure necrosis can occur 46 CVC removal This is an aseptic technique performed by a doctor or qualified nurse. Steps: 1-Hand washing 2-Explain procedure to patient 3- Position patient lying flat in bed with one pillow under shoulders and head, it may prevent air being aspirated into the venous system 4-Put on non-sterile gloves 5-Stop any IV infusions running through CVC 6-Remove old dressing 7- Put on sterile gloves 8- Clean insertion site with cleansing solution (chlorhexidine) 9- Remove the sutures. 10- Instruct patient to take deep breath and perform Valsalva maneuver as catheter is withdrawn in smooth, continuous motion. Valsalva maneuver reduces the risk for air embolus by decreasing negative pressure in respiratory system. 11- As the catheter is withdrawn; apply gentle pressure around the exit site using a sterile dressing. Stop removal procedure if resistance is met while removing catheter. 12- If the tip of the CVC is required for microbiology, it should be placed into a sterile container 13- Apply 2x2 gauze dressing over the site and secure tape. 14- Reposition the patient for comfort and observe the site closely for 30 minutes for any abnormalities. 47 Anatomy and physiology of the heart: The heart is situated in the anterior thoracic cavity, just behind the sternum and above the diaphragm; generally, the size of an individual’s heart is about the same as that person’s clenched fist. In an adult, the heart averages 12 cm in length and 8 to 9 cm in breadth at the broadest part. The weight of the normal heart averages 330 g in men, and 245 g in women. No significant differences exist in ventricular wall thickness between men and women. Layers of the Heart The four distinct layers of the heart wall are: (1) Pericardium: the outermost fibrous pericardium is a thick envelope that is tough and inelastic, inside the fibrous layer is an inner, double-walled membrane described as the pericardium. The two layers are labeled parietal (outer layer) and visceral (inner layer, also known as the epicardium. 48 (2) The epicardium, also known as the visceral pericardium, is tightly adhered to the heart and the base of the great vessels. The coronary arteries lie on the top of the epicardium. (3) Myocardium is a thick, muscular layer that includes all the atrial and ventricular muscle fibers necessary for contraction. (4) Endocardium : The innermost layer of the heart is the endocardium, which is a thin layer of endothelium and connective tissue lining the inside of the heart. Cardiac Electrophysiology: The cardiac conduction system generates and transmits electrical impulses that stimulate contraction of the myocardium. Under normal circumstances, the conduction system first stimulates contraction of the atria and then the ventricles. The synchronization of the atrial and ventricular events allows the ventricles to fill completely before ventricular ejection, thereby maximizing cardiac output. Three physiologic characteristics of two types of specialized electrical cells, the nodal cells and the Purkinje cells, provide this synchronization: Automaticity: ability to initiate an electrical impulse Excitability: ability to respond to an electrical impulse Conductivity: ability to transmit an electrical impulse from one cell to another 49 Conduction system: To analyze electrical activity within the heart, it is helpful to understand the main areas of impulse propagation and conduction: Sinoatrial (SA) node. The SA node is located at the junction of the superior vena cava and the right atrium. The SA node is considered the natural pacemaker of the heart because it has the highest degree of automaticity, producing the fastest intrinsic heart rate (HR 60-100 b/m). Internodal pathways. The electrical impulses initiated by the SA node are conducted along the myocardial cells of the atria via specialized tracts called internodal pathways. The impulses cause electrical stimulation and subsequent contraction of the atria Atrioventricular (AV) node. The AV node is located on the right side of the inter atrial septum on the floor of the right atrium, electrical impulses initiated in the atria are conducted to the ventricles only via the AV node Intrinsic rate is 40–60 bpm. The AV node performs the following essential functions to support cardiac conduction: 1. The AV node delays the conduction impulse from the atria (0.8 to 1.2 seconds). 2. The AV node controls the number of impulses that are transmitted from the atria to the ventricles. 3. The AV node acts as a backup pacemaker if the faster SA node fails. Bundle of His. 50 Located at the top of the inter ventricular septum, this bundle of fibers extends directly from the AV node and connects the atria and ventricles electrically. Bundle branches. The bundle of His splits into two conduction paths called the right and left bundle branches. These bundles carry electrical impulses at high speed to the tissue of the interventricular septum, and to each ventricle simultaneously. Purkinje system. The bundle branches terminate with this network of fibers, which spread electrical impulses rapidly throughout the ventricular walls. Intrinsic rate is 20–40 bpm. 51 Electrocardiogram (ECG) Introduction Coronary heart disease remains a leading cause of mortality worldwide. Promptly recognizing and treating acute coronary syndromes, such as STsegment elevation myocardial infarction (STEMI) and non-STEMI acute coronary syndrome, can reduce and prevent cardiac arrest. One of the most valuable and frequently used diagnostic tools, an electrocardiogram (ECG) can display the heart’s electrical activity as waveforms. Impulses moving through the heart’s conduction system create electrical currents that can be monitored on the body’s surface Definition of ECG Is the graphic representation of the electrical currents of the heart. The ECG is obtained by placing disposable electrodes in standard positions on the skin of the chest wall and extremities. A standard 12-lead ECG contains six limb lead images and six chest (precordial) lead images, and the correct placement of these leads is vitally important to avoid misdiagnosis Indication of ECG: Dysrhythmias such as (AF. SVT. VT. VF). The effects of antiarrhythmic medications. Conduction abnormalities and chamber enlargement. Myocardial ischemia, injury or infarction. Cardiac effects of electrolyte disturbances (high or low calcium and potassium levels) Check how well mechanical devices that are implanted in the heart, such as pacemakers 52 Types of ECG procedure: Standard 12 lead ECG (Resting ECG). Stress or exercise ECG (treadmill test). Ambulatory ECG (Holter monitoring) Right ECG Posterior ECG Standard 12 lead ECG procedure Steps Rational A) Assessment 1- Patient’s medical records: Physician’s order Patient’s name, age and gender. Diagnosis of the patient Patient’s history of cardiac dysrhythmias or cardiac surgery (CABG). Previous ECG. Lab investigation (CK, CKMB and troponin, serum potassium, calcium and magnesium). 2- Patient Vital signs Level of consciousness Pacemaker Patient’s extremities and chest area. To identify types of ECG Identify indication for ECG To compare recent ECG with previous. For areas of breakdown, or excessive hair that might with electrode Signs and symptoms as chest pain, interfere placement. tachycardia, palpation ,cyanosis, dizziness) B) Preparation 1-Equipment : ECG machine with recording paper Electrodes or disposable pre-gelled electrodes Hair clippers (optional, depending on hair at 53 electrode sites) 4 × 4 gauze pads or washcloth Marking pen Bath blanket or sheet Gloves, alcohol pad. Additional PPE, as indicated. Skin cleanser and water, if necessary 2-For ECG machine: Place the ECG machine close to the patient’s bed. Check the cable and wires for fraying or breakage, and replace them or obtain another machine if necessary. Plug the cord into the wall outlet, or ensure proper functioning if the machine is battery operated. Turn on the machine and input the required patient information. Ensure that the paper speed selector is set to The machine will record a normal standardization the standard 25 mm/second and that the mark—a square that’s the machine is set to full voltage. height of 2 large squares or 10 Calibrate to 10mm/mV. small Ensure that there is sufficient Paper. recording paper 3-Environment : Close doors, windows and pull curtains. Ensure adequate lightening. Ensure the environment is warm. 54 squares on the Raise the bed to waist level when providing patient care to prevent caregiver back strain. 4- For self: Hand washing. Wear gloves and PPE (if needed). 5-For Patient : Confirm the patient’s identity using at least two patient identifiers. Explain the procedure to the patient. Tell the patient that the test records the heart’s electrical activity, and that it may be repeated at certain intervals. Emphasize that no electrical current will enter the body. Also, tell the patient that the test typically takes just a few minutes C)Implementation Position the patient in a supine position in the To minimize muscle trembling, which can cause electrical center of the bed with arms at the sides. interference. Raise the head of the bed if necessary. To promote comfort. Make sure the feet do not touch the beds footboard. Ensure the patient’s arms and legs remain relaxed Expose the patient’s arms, legs, and chest, 55 and then cover the patient appropriately with a bath blanket or sheet. Select the electrode sites. Select flat, fleshy areas to place the limb lead electrodes. Avoid muscular and bony areas. If the patient has an amputated limb, choose a site on the residual limb. If an area is excessively hairy, clip the hair (don’t shave). Wash the electrode site with soap and water Which helps remove the outer and a washcloth and wipe them with a dry layer to facilitate electrical washcloth or gauze pad to roughen the skin. signal transmission. If necessary Mark the sites with an indelible marker if serial ECGs are performed. Connect the lead wires to the electrodes. Note that the tip of each lead wire is lettered and color-coded for easy identification Red RT arm Black RT leg Yellow Lt arm Green Lt Leg Apply disposable pre-gelled electrodes to the To guarantee the best connection patient’s wrists and to the medial aspects of to the lead wire, position electrodes on the patient’s legs the ankles. with the lead connections pointing superiorly. Expose the patient’s chest and apply a pregelled electrode at each electrode position on To guarantee the best connection the patient’s chest. If the patient is female, be to the lead wire sure to place the chest electrodes below the breast tissue. Note: disposable electrode applies directly to the prepared site, as recommended by the manufacturer. 56 • V1: Fourth intercostal space at right sternal border. • V2: Fourth intercostal space at left sternal border. • V3: Halfway between V2 and V4. • V4: Fifth intercostal space at the left midclavicular line. • V5: Fifth intercostal space at anterior axillary line (halfway between V4 and V6) • V6: Fifth intercostal space at midaxillary line, level with V4. Ask the patient to relax and breathe normally. Tell the patient to lie still and not to talk when you record the ECG. Press the AUTO or START button. Observe the tracing quality. The machine will record all 12 leads automatically, recording 3 consecutive leads simultaneously. When the machine finishes recording the 12lead ECG, turn off the machine, remove the electrodes, and clean the patient’s skin. After disconnecting the lead wires from the electrodes, dispose of the electrodes, as indicated. 4)Post care Return the bed to the lowest position To minimize artifact Some machines have a display screen so you can preview waveforms before the machine records them on paper To prevent falls and maintain patient safety. Clean and dry patient skin and cover the patient’s arms, legs, and chest, and then return patient to comfortable position Remove gloves and hand washing Clean, disinfect, and prepare the equipment for future use. 57 Open door, window and curtains 5)Documentation Verify the date, time, patient’s name, date of birth assigned identification number on the ECG itself and other relevant information, such as symptoms that occurred during the recording. Document the date and time the ECG was obtained and significant responses by the patient in the patient’s medical record Note any appropriate clinical information on the ECG and place it in the patient’s medical record. Right electrocardiogram An electrocardiogram (ECG) that measures the electrical activity of the heart. Unlike a standard 12-lead ECG, used primarily to evaluate left ventricular function, a right chest lead ECG reflects right ventricular function and provides clues to damage or dysfunction in this chamber. Indications for RT ECG Right chest lead ECG for a patient with an inferior wall myocardial infarction (MI) and suspected right ventricular involvement. Procedure All steps of standard ECG except chest lead site 58 V1 R (4th Intercostal space) to right of sternum. V2 R (4th Intercostal space) to left of sternum. V3 R directly between V1 and V4. V4 R (5th Intercostal space) at right midclavicular line. V5 R (5th Intercostal space) at right anterior axillary line. V6 R (5th Intercostal space ) at right midaxillary line . Posterior Electrocardiogram POSTERIOR CHEST LEAD is a recording of the electrical activity of the heart. The 12-lead ECG is an essential diagnostic tool in the management and treatment of ischemic heart disease, but because of the location of the heart’s posterior surface, changes associated with myocardial damage may not be apparent on a standard 12- lead ECG. To help identify posterior involvement, some practitioners recommend using posterior chest leads in addition to the limb leads of the 12-lead ECG despite lung and muscle barriers. Indication for posterior ECG: Posterior leads may provide clues to posterior wall infarction. Because patients with coexisting posterior infarction are at greater risk for 59 complications so acute therapy, including thrombolysis and angioplasty, shouldn’t be delayed. Procedure V1, V2, V6 at the same place at anterior chest wall. To ensure an accurate electrocardiogram (ECG) reading, make sure that the posterior leads V7, V8, and V9 are placed at the same level horizontally as the V6 lead at the fifth intercostal space. Place V6 at the midaxillary line. Place lead V7 at the posterior axillary line, lead V9 at the left paraspinal line, and lead V8 halfway between leads V7 and V9. ECG Interpretation P wave represents atrial depolarization. The PR interval is measured from the beginning of the P wave to the beginning of the QRS complex. The PR interval is normally 0.12 to 0.20 seconds long and represents the time it takes for the electrical impulse to travel from the SA node to the AV node The QRS complex represents ventricular depolarization (the time it takes for the impulse to travel through the bundle branches to the Purkinje fibers). QRS complex duration is normally less than 0.11 second (2.5 small boxes) 60 The ST segment is the portion of the ECG waveform that extends from the end of the QRS complex to the beginning of the T wave. QT interval is measured from the beginning of the QRS complex to the end of the T wave and indicates the total time from the onset of ventricular depolarization to the completion of ventricular repolarization. The U wave follows the T wave, but isn’t always seen. Introduction: An exercise ECG is performed to assess the heart's response to stress or exercise. The ECG is monitored while a person is exercising on a treadmill or stationary bike. Definition: Exercise stress testing is a noninvasive test. It consists of an ECG tracing during a period of physiologic stress on the heart muscle and its blood supply to discover and diagnose ischemia that is not apparent at rest. 61 Indications of stress ECG: Diagnose coronary artery disease. Causes of chest pain,shortness of breath or lightheadedness. Functional capacity of the heart after an MI or heart surgery. Effectiveness of antianginal or antiarrhythmic medications. Occurrence of dysrhythmias. Contraindications of stress ECG: Acute MI within 48 hours, unstable angina. Uncontrolled dysrhythmias with hemodynamic compromise. Severe aortic stenosis. Acute myocarditis or pericarditis, and decompensated HF. Unstable angina not yet stabilized with medication. Severe pulmonary hypertension. Pulmonary embolism (a clot in the arteries of a lung). Acute renal failure –infection). Procedure: Physiologic stress is created by asking the patient to walk on a treadmill or to ride a stationary bicycle. Exercise places unique demands on the cardiovascular system. Systemic oxygen consumption increases markedly, requiring the heart to increase CO to meet these demands. Myocardial contractility increases, resulting in greater SV and systolic blood pressure. HR is increased as a result of circulating catecholamines. 62 When the myocardial demand for oxygen increases during exercise, coronary blood flow must increase to maintain an adequate oxygen supply. In patients with CAD, coronary blood flow cannot increase sufficiently to meet the high metabolic needs of the myocardium during exercise, and ischemia results. Stress test protocols. Numerous protocols have been developed using a treadmill. Two popular ones: Bruce protocol, in which the grade and speed are varied every 3 minutes. Balke protocol, in which speed remains constant and grade is gradually increased every minute. Regardless of the protocol used, the heart rate and rhythm is monitored continuously. Blood pressure is also measured and recorded every minute during the test. The diagnostic value of the test is based on the maximal HR achieved, not on the length of time that the patient remains on the treadmill. Clinical reasons to stop a treadmill test. A treadmill test may be aborted before maximal HR is reached if symptoms occur (development of moderate to severe anginal or chest pain). Signs of pallor or poor perfusion, and the patient asking to stop the test. ST segment elevation or ST depression or cardiac dysrhythmias. 63 Increased symptoms such as breathlessness or fatigue or a fall in blood pressure of 10 mm Hg or more from baseline. Elevated blood pressure: blood pressure is expected to rise during exercise, but a systolic blood pressure greater than 250 mm Hg or a diastolic blood pressure greater than 115 mm Hg is an indication to stop the test. Patient preparation (nursing role) Nursing care before stress ECG The nurse prepares the patient for the stress test by describing how the stress test is performed, the type of monitoring equipment used, the rationale for insertion of an IV catheter, and what symptoms to report. Men should expect to have some chest hair shaved so that the electrodes will press directly against the skin. Prepare emergency equipment on stress ECG room (crash car- D.C. shock-emergency medication). The patient is instructed to fast for at least 3 hours before the test, medications may be taken with sips of water and avoid stimulants such as alcohol ,tobacco and caffeine. Clothes and rubber-soled shoes suitable for exercising are to be worn. The primary provider may instruct the patient not to take certain cardiac medications, such as beta-adrenergic blocking agents, calcium channel blocker 48 hours and digoxin 2 weeks before the test. Avoid significant exertion on test day. Take medication of hypertension. Obtain base line ECG and blood pressure. 64 Nursing care during stress ECG During an exercise stress test, the patient walks on a treadmill (most common) or pedals a stationary bicycle. Exercise intensity progresses according to established protocols. Attached 10 electrodes to the person's chest and back. The electrodes record the heart's electrical impulses and transmit them to an electrocardiograph. A machine that turns the impulses into waves on graph paper or on a monitor screen. Patient will also wear a blood pressure monitoring cuff or monitoring device during the test. The electrodes may be placed on top of a light layer of gel that conducts electricity and helps ensure clear readings. During the test, the following are monitored: 2 or more ECG leads for heart rate, rhythm, and ischemic changes; BP; skin temperature; physical appearance; perceived exertion; and symptoms, including chest pain, dyspnea, dizziness, leg cramping, and fatigue. The test is terminated when the target heart rate is achieved or if the patient experiences signs of myocardial ischemia. Further diagnostic testing, such as a cardiac catheterization, may be warranted if the patient develops chest pain, extreme fatigue, a decrease in BP or pulse rate, serious dysrhythmias, or ST-segment changes on the ECG during the stress test. Nursing care after stress ECG Remove ECG electrodes and clean chest area. Relax and reassure the patient. Monitor ECG, blood pressure and symptoms. 65 Introduction: Holter monitors are the most widely used continuous recording systems for patients with daily symptoms. Holter monitoring is used to determine how the heart responds to normal activity. This is a totally noninvasive procedure with no adverse effects. Definition A Holter monitor is a battery-operated portable device that measures and records heart’s activity (ECG) continuously for 24 to 48 hours or longer, mainly used for patients with unpredictable cardiac symptoms that occur in random and short episodes. The device is the size of a small camera. It has wires with silver dollar-sized electrodes that attach to the skin. Wearing a Holter monitor has no risks and causes no pain. Indications of Holter monitoring: Atrial fibrillation or flutter Multifocal atrial tachycardia Palpitations Paroxysmal supraventricular tachycardia Repeated fainting 66 Slow heart rate (bradycardia) Ventricular tachycardia. Procedure The patient wears skin electrodes and carries a small box that contains a digital recorder. The monitor is carried by a shoulder strap or clipped to a belt or pocket for 24 hours or longer and then is returned to the hospital or clinic for reading. All Holter monitors record between 3 and 12 leads to minimize inaccurate interpretation caused by artifact. Most systems have an event marker, which the patient can press to indicate the onset of symptoms. The patient is asked to keep a diary of activities, symptoms, and any medications that are taken. Patch monitors are a newer generation that continuously records the ECG for up to 14 days. These are small adhesive devices that are more convenient than Holter monitors but can only record in one or two leads. Activities that would get the chest electrodes or monitor wet, including swimming and taking a shower or tub bath while wearing a Holter monitor should be avoided. The patient is asked to avoid electric blankets, high-voltage areas and magnets while wearing the device 67 Introduction Definition of dialysis Types of dialysis Definition of hemodialysis Indication of hemodialysis Contraindication of hemodialysis Dialysis system Hemodialysis care (pre-during-post) Care of AV fistula or AV graft Hemodialysis complication 68 The kidney play vital role in fluid and toxins removal and when kidney function goes down from 10 to 15% of normal, a buildup of toxins (waste) and fluid in body happen. Dialysis is a form of renal replacement therapy ensures the maintenance of homeostasis (a stable internal environment) in people experiencing a rapid loss of kidney function, i.e., acute kidney injury (AKI) or chronic kidney disease (CKD). Is a form of renal replacement therapy or the kidney’s role of filtration of the blood is supplemented by artificial equipment to remove excess water, solutes, and toxins when patient can no longer be managed with conservative therapies, such as diet, drugs, and fluid restriction, dialysis is indicated. Hemodialysis (HD) Peritoneal dialysis (PD) Continuous renal replacement therapy (CRRT) 69 "Hemo" means blood and "dialysis" means filter. Is the most common renal replacement therapy used with ESKD and kidney failure. Is a procedure which dialysis removes excess fluids and waste products and restores chemical and electrolyte balance. HD involves passing the patient’s blood through an artificial semipermeable membrane to perform the filtering and excretion functions of the kidney. Acute kidney injury Uremic encephalopathy Pericarditis Life-threatening hyperkalemia Refractory acidosis Hypervolemia causing end-organ complications (e.g., pulmonary edema) Asymptomatic patients with a GFR of 5 to 9 mL/min/1.73 m² Any toxic ingestion 70 Absolute contraindication to hemodialysis is Inability to secure vascular access Sever hemodynamic instability Active bleeding Relative contraindications include: Difficult vascular access Needle phobia Cardiac failure Coagulopathy Hemodialysis removes wastes and water by circulating blood outside the body through an external filter, called a dialyzer, which contain a semipermeable membrane. Diffusion Diffusion’ is the term used to describe the movement of molecules from an area of high concentration of solutes to a region of low concentration of solutes until they are equal. Osmosis Movement of water across a semipermeable membrane from a solution that has a lower osmolarity or concentration to a solution with a higher osmolarity or concentration. Potassium and sodium typically move out of the plasma into the dialysate. Bicarbonate and calcium generally move from the dialysate into the plasma. Ultrafiltration Fluid removal is achieved by altering the hydrostatic pressure of the dialysate compartment, causing free water and some dissolved solutes to move across the membrane along a created pressure gradient 71 dialyzer, dialysate, vascular access routes, and an HD machine. 1- Dialyzer The dialyzer is the functional unit of the extracorporeal circuit just as the nephron and some patients and nurses refer to the dialyzer as the ‘kidney’ and provide highly efficient clearance of waste products. A dialyzer has four parts: a blood compartment, a dialysate compartment, a semipermeable membrane, and an enclosed support structure. The core of the dialyzer is made up of thousands of tiny mesh tubes. The blood flows inside each tube, and the dialysate stays on the outside of the tubes. Tiny pores in the tubes let waste and excess fluids pass from the blood into the dialysate. The cleaned blood then leaves the dialyzer and is returned to the body. 2-Dialysate is made from clear water and chemicals and is free of any waste products or drugs. Because bacteria and other organisms are too large to pass through the membrane, dialysate is not sterile. The water used in dialysate must meet specific standards and usually requires special treatment before mixing the dialysate. The dialysate composition may be altered according to the patient’s needs for management of electrolyte imbalances. During HD, the dialysate is warmed to 100° F (37.8° C) to increase the diffusion rate and to prevent hypothermia. 3-The HD machine Are artificial kidneys that perform most, but not all, kidney functions for patients who have permanent or temporary renal failure. The machines use hemodialysis to cleanse the blood and balance its constituents. With this process, the patient's blood is circulated through the machine where it is filtered and balanced for electrolytes, pH, and fluid concentration before being returned to the patient. It has alarm systems to monitor for potential problems 72 4- Vascular access: There are three types of accesses: Depending on patient health, the strength of your veins, and other factors, there are different types of access sites. Arteriovenous (AV) fistula 4 is surgically created by connecting an artery to a vein. It is placed in the wrist, upper arm or forearm. It is created to cause extra pressure by pushing an increase in the blood flow into the veins, making it stronger and bigger, thereby creating easy vascular access to the blood vessels. A V graft is a surgically created connection between vein and artery. It allows direct access to the bloodstream for dialysis. Usually an arm vein is connected to an artery Central venous catheter it is used for emergency hemodialysis, a plastic tube (catheter) may be inserted into a large vein in your neck and the catheter is temporary 73 FOR HEMODIALYSIS Access Type Description AV fistula AV graft Hemodialysis catheter (dual- or triple-lumen) Subcutan eous device Location Permanent An internal anastomosis of an artery to a vein Synthetic vessel tubing tunneled beneath the skin, connecting an artery and a vein Initial use Forearm 2-4 month or longer Forearm Upper arm Inner thigh 1-2 wks Temporary A specially designed catheter with two or three lumens Two Subclavian, lumens are for blood internal outflow and inflow for jugular, or hemodialysis; a third femoral allows venous access vein without accessing dialysis lumens An internal device with two metallic access ports and Subclavian two catheters inserted into large central veins Immediately after insertion and x-ray confirmation of placement Immediately after insertion Pre Dialysis Care A-Care of patient before hemodialysis -Medications such as (anticoagulant, antibiotics and vasoactive drugs ) -History of blood disorders. -Laboratory values (CBC, PT, PTT, INR, PLTs, serum electrolytes and virology). 74 -History of sensitivity or adverse reaction to a dialysate solution, iodine, or any numbing medicine. -Check vital signs especially blood pressure, Recommended pre dialysis blood pressure should be <140/90 mmHg, and <130/80 mmHg post-dialysis. -Check patient weight: The term ‘target weight’ or ‘ideal weight’ or dry weight referred to the weight at which there is no clinical evidence of edema, shortness of breath, increased jugular venous pressure or hypotension or hypertension. -Assess the patient’s level of consciousness to identify on any signs of disequilibrium syndrome. -Withdraw labs such as Na, K, Urea, and Creatinine. -Assess AV fistula or shunt condition and access site for 1. Check shunt and palpate for thrill and auscultate for bruits for AV fistula. 2. Assess the patient’s distal pulses and circulation in the arm with the access. 3. Check patency of central venous catheter, if inserted. The exit site should be examined before each dialysis and observed for signs of infection such as soreness, redness or the presence of exudate. B-Care of patient during hemodialysis -Assess and document symptoms of disequilibrium syndrome (headache, nausea, vomiting, restlessness, decreased level of consciousness, seizures and coma) during dialysis session. -Measure the blood pressure during the session continuously every 1 /2or 1 hour because hypotension is a very common complication associated with hemodialysis and is probably a reflection of the large amounts of fluid that is removed during the procedure. 75 -In the patient being dialyzed via a fistula or graft the heparin infusion should be switched off 30 minutes before the end of the dialysis session to prevent the risk of bleeding from the access site post dialysis. C-Care of patient after hemodialysis -Closely monitor the patient immediately and for several hours after dialysis for any side effects from the treatment. -Obtain vital signs -weight the patient. -If the patient has a fever, sepsis may be present and a blood sample is needed for culture and sensitivity. Caring for the Patient with an Arteriovenous Fistula or Arteriovenous Graft Do not take blood pressure readings using the extremity in which the vascular access is placed. Do not perform venipuncture or start an IV line in the extremity in which the vascular access is placed. Palpate for thrills and auscultate for bruits every 4 hours while the patient is awake. The bruit and thrill should be checked regularly (half-hourly at first) and the patients should be taught how to perform these observations as soon as they are able. Assess the patient’s distal pulses and circulation in the arm with the access. Elevate the affected extremity postoperatively. Encourage routine range of motion exercises. The wound site should be examined regularly for signs of excess bleeding or swelling. 76 The blood flow through the fistula should be checked regularly Check for bleeding at needle insertion sites. Assess for manifestations of infection at needle sites. Instruct the patient not to carry heavy objects or anything that compresses the extremity in which the vascular access is placed. Instruct the patient not to sleep with his or her body weight on top of the extremity in which the vascular access is placed Patients should be advised to contact the hospital immediately if they notice bleeding, swelling or absence of bruit or thrill Evaluate reports of pain, numbness, or tingling; note extremity swelling distal to access as this may indicate inadequate blood supply. Assess skin around vascular access, noting redness, swelling, local warmth, exudate, and tenderness. The most common complications associated with hemodialysis are: 1. Intradialytic hypotension: This causes poor long-term outcomes due to increased mortality known as myocardial stunning. A BP lower than 90 mmHg strongly correlates with mortality. It usually presents as dizziness, lightheadedness, and nausea. 77 Management Maintaining the patient in the Trendelenburg position. Rapidly administering a 100 mL bolus of normal saline through the bloodline. Reduce the ultrafiltration rate and observe the patient until vitals have stabilized. 2. Muscle cramps: Hypotension, high ultrafiltration rate, hypovolemia, and lowsodium dialysis solution predispose to cramps. These factors trigger vasoconstriction and muscle hypo-perfusion, with secondary impairment of muscle relaxation. Management When occurring concomitantly with hypotension Treatment with 0.9% saline is effective. Forced stretching of the muscle involved provide relief of cramps. Reduce the ultrafiltration rate. 3- Dialysis disequilibrium syndrome: This is more common in patients during or soon after their first treatment. It is a clinical syndrome characterized by neurologic deterioration, restlessness, mental confusion, headache, occasional muscle twitching, and coma. It occurs due to a substantial gradient between the urea concentrations in the CSF and blood that causes water movement into the central nervous system (CNS), resulting in raised intracranial pressure. Patients undergoing fast dialysis develop seizures and cerebral edema more often. Management It is a medical emergencies and must be managed by an immediate stopping of dialysis, clamping of lines, and supportive care followed by definitive care 78 Adding an osmotic agent to the blood could prevent the gradient from forming. Sodium, mannitol, high glucose dialysate, and glycerol are usually added. Setting the dialysate’s sodium concentration higher throughout the treatment may be beneficial. 4- Dialyzer reactions: it is anaphylactic reaction present with dyspnea, increased body and local temperature at the fistula site, a feeling of impending doom, itching, urticaria, watery eyes, abdominal cramping, and diarrhea. Symptoms may begin anytime during the first 30 minutes following dialysis due to hypersensitivity to ethylene oxide used to sterilize dialyzers. Management Intravenous antihistamines, steroids, and epinephrine. Proper rinsing of dialyzers before use eliminates residual allergens and helps prevent them. 5- Hemolysis: Acute hemolysis during dialysis is a medical emergency indicated by the port-wine appearance in the venous blood line, a marked fall in the hematocrit, and a pink-colored plasma centrifuged blood sample. The patient should be evaluated by hematologic investigations and kept under observation for delayed hemolysis. A dialysate sample must be investigated to find the cause. 6- Air embolism: This is a fatal complication with foam noted in the dialyzer’s venous blood line. A churning sound may be heard during chest auscultation. Management Place the patient in a left lateral recumbent position. Clamp blood lines and stop blood pump. Normal saline to support blood pressure. Administer 100% oxygen by mask and aspirate air from the cardiac chambers with a percutaneously inserted needle or cardiac catheterization. 7. Vascular access dysfunction, most commonly stenosis of arteriovenous access, is the strongest determinant of the quality of life of a dialysis 79 patient. There are reduced blood flow and risk for thrombosis. The formation of a catheter-related fibro-epithelial sheath also hampers blood flow. Management Urokinase instillation, endovascular catheter stripping, or replacement of the indwelling dialysis catheter in a subcutaneous tunnel re-establish access. 8- Other nonspecific complications include nausea and vomiting (10%), headache (70%), chest and back pain (1% to 4%), and itching. These are probably related to hypotension or could be an early manifestation of disequilibrium syndrome. Treating the associated hypotension resolves the symptoms. A single predialysis dose of 5 to 10 mg metoclopramide is sufficient. Acetaminophen given during dialysis can help manage the headache. Switching to a different type of dialyzer membrane could reduce itching caused by low-grade hypersensitivity to blood circuit components. 80 OUTLINES Blood Physiology Introduction Terminology Indications Contraindications Methods of plasma separation Complications Nursing Care 81 Blood Physiology Blood is a fluid that moves through the vessels of a circulatory system. The main components of blood are: plasma red blood cells white blood cells platelets What is plasma? Plasma is the liquid portion of the blood that transports water and nutrients to all the cells in the body. It is composed of approximately 92% water, 7% proteins and 1% other component. Plasma contains many specialized proteins (antibodies) that aid in fighting infections and can be used to make life saving medical products. 82 Introduction Plasmapheresis is a term used to refer to a broad range of procedures in which extracorporeal separation of blood components results in a filtered plasma product. It is a process in which plasma is separated from blood cells and then plasma is replaced with another solution like albumin of FFP. The underlying mechanism of this procedure is accomplished by either centrifugation or filtration using semipermeable membranes. This intervention results in a filtered plasma product that can be used for the treatment of numerous diseases. TERMINOLOGY Apheresis: is a medical procedure that involves removing blood from a patient, separating the blood into its individual components, and then returning the desired components to the patient. Plasmapheresis Plasmapheresis is a therapeutic intervention that involves extracorporeal removal, return, or exchange of blood plasma. Plasma Exchange is another type of apheresis that involves removing the patient’s plasma and replacing it with donor plasma or a plasma substitute. Indications of plasamaheresis A. Autoimmune Disorders: Plasmapheresis is often used to manage autoimmune diseases by removing harmful antibodies or immune complexes from the plasma. B. Neurological Conditions: Certain neurological disorders, such as GuillainBarré syndrome or myasthenia gravis, may benefit from plasmapheresis to reduce autoantibodies affecting the nervous system. C. Hematological Disorders: It can be employed in conditions involving abnormal proteins in the blood, like cryoglobulinemia or hyperviscosity syndrome and thrombotic thrombocytopenic purpura. D. Some types of Caners: Lymphoblastic lymphoma: This is a blood cancer that happens when lymphoid cells in bone marrow or lymph nodes produce unusually large 83 amounts of the antibody immunoglobulin M. Providers use plasma exchange to filter the antibody from the plasma. Multiple myeloma: This is a blood cancer that happens when the bone marrow produces abnormal plasma cells that become cancerous and multiply. The American Society for Apheresis (ASFA)periodically revises the indications for plasmapheresis and classifies them according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. The following are some of the indications, and their categorization, from the society’s guidelines. Category I (disorders for which apheresis is accepted as first-line therapy, either as a primary standalone treatment or in conjunction with other modes of treatment) are as follows: Guillain-Barre syndrome. Myasthenia gravis. Chronic inflammatory demyelinating polyneuropathy. Hyperviscosity in monoclonal gammopathies. Thrombotic thrombocytopenic purpura. Goodpasture syndrome (unless it is dialysis-dependent and there is no diffuse alveolar hemorrhage). Hemolytic uremic syndrome (atypical, due to autoantibody to factor H). Wilson disease. Category II (disorder for which apheresis is accepted as second-line therapy, either as a standalone treatment alone or in conjunction with other modes of treatment) are as follows: Lambert-Eaton myasthenic syndrome. Multiple sclerosis (acute central nervous system demyelination disease unresponsive to steroids). RBC alloimmunization in pregnancy. Mushroom poisoning. Acute disseminated encephalomyelitis. 84 Hemolytic uremic syndrome (atypical, due to complement factor mutations). Autoimmune hemolytic anemia (life-threatening cold agglutinin disease). Systemic lupus erythematosus (severe). Myeloma cast nephropathy. Category III (disorders for which the optimal role of apheresis therapy is not established; decision-making should be individualized) are as follows: Post-transfusion purpura. Autoimmune hemolytic anemia (warm autoimmune hemolytic anemia). Hypertriglyceridemic pancreatitis. Thyroid storm. Category IV (disorders in which published evidence demonstrates or suggests apheresis to be ineffective or harmful; institutional review board [IRB] approval is desirable if apheresis treatment is undertaken in these circumstances) are as follows: Stiff person syndrome. Hemolytic uremic syndrome (typical diarrhea-associated). Systemic lupus erythematosus (nephritis). Immune thrombocytopenia. Contraindications Non-availability of central line access or large bore peripheral lines Hemodynamic instability or septicemia. Severe Anemia. Coagulation Disorders. Allergic Reactions: to substances used in plasmapheresis )Known allergy to fresh frozen plasma or replacement colloid/albumin. Known allergy to heparin. Hypocalcemia (restricts the use of citrate as an anticoagulant during the procedure); relative contraindication. Angiotensin-converting enzyme (ACE) inhibitor used in last 24 hours, relative contraindication. 85 Plasma volume in a normal person is approximately 35-40 ml/kg body weight. The lower number 35 is applicable to patients with normal HCT values, and 40 is applicable to patients with HCT less than normal. Plasma removal during the first session is usually 20 ml/kg and 40 ml/kg in subsequent sessions. There is a simplified method (Kaplan s equation) for predicting the estimated Plasma volume = }0.065 X weight(kg) X (1- Hct) [ Hematocrit = %[hematocrit]/100 Methods of Separation 1. Centrifugal plasma separation Blood from the patient is taken into port, anticoagulant is added (mostly citrate). Blood goes to the centrifugal cell separation machine. Cells go peripherally and plasma remains in the center. Plasma goes into the plasma collector. Cells are sent back to the patient s body and replacement fluid is given. 86 2. Membrane Plasma separation This technique is used in the dialysis machine. Blood drawn from the patient mixed with anticoagulant (heparin). Blood passed through a hollow fiber plasma filter. Plasma is filtered off and plasma is collected and discarded. Cells along with colloid replacement forms new blood. New blood is given back to the patient's body. Centrifugal cell separation Membrane plasma filtration The molecular weight of the substance No upper limit Membrane pore size 0.2 to 0.5 micrometer All immunoglobulins (IgG> IgM) Size - 3 million Dalton Blood flow 50-150 ml/min 100-300 ml/min Access Large bore peripheral cannula adverse effects Thrombocytopenia- in 50% of patients Blood flow >300 ml/min- cause hemolysis Takes longer Anticoagulation Citrate Heparin Factor AV access (fistula or jugular cannula) Replacement Fluid Removal of plasma- 50 ml/kg/body weight. Plasma volume is replaced with crystalloid or Human albumin/colloid and FFP (Fresh Frozen Plasma). Crystalloid - normal saline, Hypoproteinemia and hypotension occur if normal saline alone is used as replacement fluid. Colloid – albumin. Depletion coagulopathy occurs if albumin alone is used as replacement fluid. Can be used in all exchanges except TMA. Fresh Frozen Plasma- To replenish coagulation factors fresh frozen plasma is given, given at the end of the cycle. To be used when bleeding risk is high. Each session depletes- 60% of immunoglobulins. 5 sessions deplete 90% of 87 immunoglobulins. Always plasmapheresis must immunosuppression to control disease progression. be combined with Plasma volume= total blood volume × (1-hematocrit). Total blood volume is 75% of body weight in males and 65% of body weight in females. Plasma to be removed= plasma volume/body weight. Choice of replacement solution Solution Albumin Fresh Frozen Plasma Crystalloid Solutions Advantage No risk of hepatitis No concern about ABO blood group Allergic reactions rare Coagulation factors Immunoglobulins Inexpensive No side effects. No risk of infection Disadvantage Expensive No coagulation Factors. No immunoglobulins Risk of hepatitis Allergic reactions Must be ABO Compatible Citrate load Do not maintain oncotic pressure. Technique: The steps for performing plasmapheresis using centrifuge-based equipment are as follows: 1. Initially, a waste of around 3-5 mL of blood from the central venous catheter is discarded. 2. After drawing baseline samples for complete hemogram, calcium, and fibrinogen, it is flushed with 5-10 mL of heparinized saline. 3. The double-lumen catheter is now connected to the machine tubing to start the priming procedure. 4. The machine calculates total body volume (TBV), and the effective plasma volume (which equals TBV × (1 – hematocrit)) of the patient based on the operator entered height and weight. 88 5. The replacement product to be used and its desired volume (40 60 mL/kg) is decided by the clinician, and entered into the machine, based on which it calculates the centrifuge speed. 6. The separated plasma is discarded by the machine, and the RBCs are returned back to the patient along with the replacement fluid. 7. Finally, post-procedure, tubing are connected to heparinized saline, and reinfusion is initiated 8. Post-plasmapheresis blood for fibrinogen and calcium is sent again, and lumens of central venous catheters are flushed. Complications Related to Vascular access. Hematoma Pneumothorax Retroperitoneal bleed Related to Procedure Hypotension Bleeding Edema 89 Loss of cellular elements (plts) Hypersensitivity reactions Related to Anticoagulation Metabolic Alkalosis from citrate Bleeding Hypocalcemic Symptoms: Tingling and numbness, arrhythmias, hypotension NURSING CARE Before apheresis procedure A TPE order must be checked the following information: - Number of plasma volumes (PV) to be exchanged - Replacement fluid to be used :(albumin volume and no of plasma units For TPE, the most commonly used replacement fluids are 5% human albumin solution and plasma, including frozen plasma (FP) or fresh frozen plasma, (FFP), also normal saline may be used in combination with albumin or plasma. - Vascular access site - Anticoagulant therapy - Frequency and estimated total number of treatments Informed consent for apheresis requires that the patient or substitute decision-maker is fully aware of the risks and potential benefits of this treatment. The Patient should be asked to avoid caffeine containing liquids twenty four hours before procedure due to their diuretic action. Patient should empty the bladder prior to the procedure Comfortable clothing with loose fitting sleeves that pull easily above the elbow will make it easier to place the needle in each arm. 90 The physical examination of the patient should include, at minimum, vital signs, weight, and venous access (peripheral or central) Laboratory tests of a complete blood count; electrolytes and creatinine; calcium, magnesium, phosphate, albumin and coagulation profile (PT, PC and INR) must be checked. Additional laboratory studies may also be necessary, depending on the indication for apheresis. All the equipment must be available and ready to use. During apheresis procedure Patient - Monitor vital signs: heart rate, blood pressure, temperature, saturation, central venous pressure (CVP) - Assess patient for headache, hypotension, muscle cramps, backache, and nausea or vomiting. - Calcium may be infused intravenously while the patient is undergoing the plasmapheresis; in addition, calcium supplementation by mouth may also be given to prevent muscle cramps and hypocalcemia. - Neurological status assessment - Assess vascular access for bleeding Apheresis machine Complete checkup of the apheresis circuit - Monitor pump flow rate - Monitor for Any alarms After apheresis procedure - Check vital signs Check for any reaction Monitor venous access site for bleeding. Keep an accurate record of the patient replacement fluid. Monitor patient weight. 91 Portacath care Introduction: A port-A-Cath is considered a central line, it is surgically implanted. An implanted port consists of a subcutaneous injection port attached to a catheter. The tip of the catheter is inserted in the subclavian vein and advanced to the superior vena cava. Definition: An implantable port is a type of intravenous (IV) access system that is inserted underneath the skin in the upper chest. It is sometimes called a Portacath or TIVAD (totally implanted venous access device). It consists of a fine tube, or catheter, connected to a small chamber with a selfsealing silicone membrane providing easy access to one of larger veins. Advantage: Prevention and reduction of infection in the line and ensures the portacath can be used for many years if required. 92 Patients with very small veins which can be damaged with the chemotherapy drugs, or have difficult access, making a port ideal for them. Easy and quick access with less pain than typical needle sticks. Longevity of device use. Low-maintenance care at home Body image (not noticeable under the skin) Able to give multiple treatments at the same time (i.e. blood and antibiotics) Nothing external when the port is not in use Purpose Collect blood samples. Intravenous (IV) medication such as anesthesia and some types of chemotherapy, must go through a large vein. IV fluids. IV blood products, such as platelets and plasma. IV contrast. Nutritional feeding. Long term IV medications. Contraindication Skin infection, skin rash, or a newly tattooed area. Extensive scarring from burns, surgery, injuries, repeated venipuncture, or trauma. Hematoma Lymphedema: The upper extremity on the ipsilateral side of a mastectomy should be avoided owing to the frequent presence of lymphedema occurring after dissection and removal of the lymphatic system 93 Types of Ports A port can be single or double-lumen. Single-lumen ports are most common and typically sufficient for patients requiring scheduled intravenous therapy. A double-lumen port is advantageous for patients who often receive multiple intravenous therapies at once. If two intravenous agents aren’t compatible in the same line, you can infuse both simultaneously in different port lumens without complication. -The double-lumen port also allows a concurrent infusion of medication, chemotherapy, blood products, or parenteral nutrition. It is also beneficial for drawing labs without interruption of an infusion. A Power Port is a special type of port, available in single or double-lumen, which can withstand higher injection pressures. This is an important consideration for receiving intravenous CT contrast dye. A Power Port must be accessed with a particular type of needle, a PowerLoc needle, in order to inject contrast. A single-lumen port is a port with 1 access point. A double-lumen port is a port with 2 access points. A needle can be put in each access point. 94 The portal chamber is always characterized by a triangular-shaped body, which can be palpated under the skin. In addition, a patient with a PowerPort will receive a wallet-sized identification, keyring card, and bracelet. It is helpful for patients to carry one or all of these identifiers to help healthcare professionals in the future appropriately access and utilize the PowerPort. Location of the port The surgeon determines the location of the port on the body based on a patient’s internal anatomy or personal preference. It is most often placed under the subcutaneous tissue of the chest, upper arm, or lower rib cage. 95 Procedure Steps Rational A. Assessment 1. Patient's medical record: Physician order Patient’s name, age and diagnosis. Patient’s medications especially anticoagulant. History of: - Blood disorders and lab investigations such as PT, PTT and INR. - Allergy to the antiseptic, anesthetic, or prescribed solution. - Length of time the port has been in - If the port has been placed recently, assess surgical incision. Note presence of Steri-Strips, approximation, ecchymosis, redness, edema, and/or drainage. place. Prescribed medication (ten rights). Special consideration according to different types of medications. Blood test as ordered 2. patient assessment The level of consciousness, - To determine the need for sedation or paralytic agents. level of anxiety Assess patient skin for any 96 swelling, redness, or drainage Assess patient level of pain B-Preparation - To save time and effort. 1. Prepare equipment • Sterile tape or Steri-Strips • Sterile semipermeable transparent dressing • Several 2 x 2 gauzes • Sterile towel or drape • 2% chlorhexidine solution • Normal saline (NSS) vial and 10-mL syringe or prefilled 10-mL NSS syringe. • Heparin 100 U/mL in 10-mL syringe or 10 U/mL/kg. • Noncoring needle (Huber needle) of appropriate length and gauge • Masks (2) • Clean gloves • Sterile gloves • Additional PPE, as indicated • Skin protectant wipe • Alcohol wipe • Povidone-iodine wipes • Positive pressure end cap • IV securement/stabilization device, as appropriate • Bath blanket 97 2- For self: Hand washing. -To prevent cross infection Put on disposable gloves. Wear PPE if needed 3- For environment: Close doors, windows and pull curtains. - To maintain patient privacy. Ensure adequate lighting. Maintain bed at high comfortable position at waist level to ensure body mechanics. Place a waste receptacle or bag at a convenient location for use during the procedure. 4. For patient: Check the patient identification. Explain The procedure & reason for portacath care Put patient in comfortable position that provides easy access to the port site. C) Implementation Needle insertion 1. Use the bath blanket to cover any - Use of a bath blanket provide for comfort exposed area other than the site. and warmth. 2. Put on clean gloves. 98 - Palpate the location of the port and - Knowledge of location and boundaries of assess site. port are necessary to safely access site. - Note the status of any surgical incisions that may be present. - Remove gloves and discard. 3- Prepare a sterile field, apply sterile gloves and wear PPE. Apply sterile drape. 4- Connect the end cap to the extension tubing on the non-coring needle. 5. Clean end cap with alcohol wipe. - Priming extension tubing removes air Insert syringe with normal saline into from tubing and prevents administration of end cap. air when connected to port. - Fill extension tubing with normal saline and apply clamp. - Place on sterile field. 6. Using the chlorhexidine swab - Site care and replacement of or povidone-iodine, cleanse the dressing are accomplished using port site. Press the applicator sterile technique. Organisms on the against the skin. skin can be introduced into the - Apply chlorhexidine using a tissues or the bloodstream with the back and forth friction scrub for at needle. least 30 seconds. - Chlorhexidine is effective against - Moving outward from the site, the most common causes of catheter99 use a circular, scrubbing motion to associated central line infections continue to clean, covering at least a 2- to 3-inch area. - Do not wipe or blot. - Allow to dry completely. 7. Using the nondominant hand, - Hold the port with your locate the port. Hold the port nondominant hand so that the needle stable, keeping the skin taut (The is inserted into the port with the edges of the port must be palpated dominant hand so that the needle can be inserted into the center of the port). 8. Visualize the center of the port. - To function properly, the needle must be Pick up the needle. Coil extension located in the middle of the port and tubing into palm of hand. Holding inserted to the back of the port. needle at a 90-degree angle to the skin, insert through the skin into the port septum. 9. Pull back on the syringe Positive blood return confirms patency plunger to aspirate for blood before administration of medications and return. solutions Aspirate only a few milliliters of blood; do not allow blood to enter the syringe 100 10. Insert the syringe with normal saline. Open the clamp - If needle is not inserted correctly, fluid on will leak into tissue, causing the tissue extension tubing and flush with 3 to to 5 mL of saline, while observing infiltration. Flushing without resistance the is also a sign that the needle is inserted site for fluid leak or infiltration. It should flush easily, swell and producing signs of correctly. without resistance. Don’t forcibly flush the device 11- Remove syringe. Insert heparin syringe and instill the solution over 1 minute or according to facility policy. 12. Remove syringe and clamp the extension tubing. - Alternately, if IV fluid infusion is to be started, do not flush with heparin. 13. Apply the skin protectant to the site, - Skin protectant improves adhesion of avoiding direct application to needle dressing and protects skin from damage and insertion site. Allow to dry. irritation when dressing is removed. 14. Apply tape or Steri-Strips in a star- - Secures needle to help prevent the needle like pattern over the needle to secure it. from accidentally pulling out. Support the wings of the noncoring needle (if present) with sterile gauze. 101 15. Apply transparent site dressing or - Dressing prevents contamination of the IV securement/stabilization device, catheter and protects insertion site. centering over insertion site. 16. Label dressing with date, time of - Labeling helps ensure communication change, and initials of IV fluid infusion about venous access site dressing is ordered. change. 102 Needle removal 1. Put on gloves. Stabilize port needle with nondominant hand. 2. Clean the end cap on the extension tubing and insert the saline-filled syringe. - Unclamp the extension tubing and flush with a minimum of 10 mL of normal saline 3. Remove the syringe and insert the heparin-filled syringe, flushing with 5 mL heparin (100 U/mL or per facility policy). - Remove syringe and clamp the extension tubing 4. Gently pull back transparent dressing, beginning with edges and proceeding around the edge of the dressing. Carefully remove all the tape that is securing the needle in place 5. Secure the port on either side with the fingers of your nondominant hand. 6. Grasp the needle/wings with the fingers of dominant hand. Firmly and smoothly, pull the needle straight up at a 90-degree angle from the skin to remove it from the septum .Engage needle guard, 103 if not automatic on removal. 7. Apply gentle pressure with the gauze to the insertion site. - Apply a Band-Aid over the port if any oozing occurs. Otherwise, a dressing is not necessary. D) Post care: Return patient to comfortable To prevent cross infection. position. Open doors, windows and re- open curtains. Return equipment. Remove gloves and hand washing. E) Documentation: The location of the port and the size of needle used to access the port. signs and symptoms of infection or trauma patient’s reaction to the procedure if the patient is experiencing any pain or discomfort related to the port Medication (name and dose) 104 Unexpected outcome Port begins to swell when flushing with saline: Stop flushing. Verify that needle is against the back of the septum. Attempt to flush. If swelling persists, stop flush. Remove needle. Obtain additional supplies and reaccess port with new needle. Check blood return and flush. If swelling persists, stop flush. Depending on facility policy, leave access needle in place. Cover with transparent dressing. Notify primary care provider. Anticipate diagnostic tests to determine patency of port. Port does not flush: Check clamp to make sure it is open. Gently push down on needle and again try to flush. Ask the patient to perform a Valsalva maneuver. Try having the patient change position or place the affected arm over the head, or try raising or lowering the head of the bed. If the port still does not flush, remove needle. Obtain additional supplies and reaccess with new needle. Check blood return and flush. If still unable to flush, notify primary care provider. Depending on facility policy, leave access needle in place. Cover with transparent dressing. Anticipate diagnostic tests to determine patency of port. Port flushes but does not have a blood return: Ask the patient to perform a Valsalva maneuver. Try having the patient change position or place the affected arm over the head, or try raising or lowering the head of the bed. If the port still does not have a blood return, remove needle. Obtain additional supplies and reaccess with new needle. Check blood return and flush. If it still does not have a blood return, notify primary care provider. Depending on facility policy, leave access needle in place. Cover with transparent dressing. Anticipate diagnostic tests to determine patency of the port and/or instillation of thrombolytic. 105 SPECIAL CONSIDERATIONS When port is accessed and not being used for infusion, flush daily with 5 mL of heparin (patients weighing more than 10 kg, use 100 U/mL of heparin; patients weighing less than 10 kg, use 10 U/mL of heparin) according to facility policy . Groshong devices do not require the use of heparin for flushing. Heparin-induced thrombocytopenia (HIT) has been reported with the use of heparin flush solutions. Monitor all patients closely for signs and symptoms of HIT. If present or suspected, discontinue heparin. Monitor platelet counts for patient receiving heparin flush solution when there is an increased risk of HIT. No dressing is needed when the port is not accessed. If the access site becomes red, becomes painful, or has yellow-green drainage, contact your health-care provider immediately. Patency is maintained by periodic flushing. The length and gauge of the needle used to access the port should be selected based on the patient’s anatomy, amount of subcutaneous tissue at the site, and anticipated infusion requirements. In general, a 3 ⁄4-inch 20-gauge needle is frequently used. If the patient has a significant amount longer length (1 or 1.5 inch) may be selected. A larger gauge (19gauge) is preferred for administration of blood products. Complication Infection. Damage to the port Dislodgement of the port Irritation with certain clothes Occlusion or blockage Hematoma formation. Catheter thrombosis 106 Extravasation: the unintentional leakage of vesicant fluids or medications from the vein into the surrounding tissue Vesicant: agents capable of causing blistering, tissue sloughing or necrosis These drugs can be sub-classified according to mechanism of action by which they cause damage, but which is also important in that it affects the management strategy. • DNA – binding: these drugs are absorbed locally, enter cells and bind to their DNA, precipitating the death of the cell. Following this, the drug can then be re-released to further destroy healthy cells leading to deeper erosion of cells within the tissue • Non-DNA-binding: These drugs initiate cell death by mechanisms other than binding DNA and are eventually metabolized in the tissue and are more easily neutralized than the DNA-binding vesicants. Injuries resulting from these agents generally remain localized and improve over time Non-Vesicants: Inert or neutral compounds that do not cause inflammation or damage. Do not cause ulceration, however they do tend to cause pain at, and around the injection site, and along the vein. 107 Causes of extravasation Diagnosis: Patients must be informed to report any changes in sensation, signs, or symptoms during the IV administration of any chemotherapeutic drug and to alert the healthcare professionals to early signs of extravasation. Extravasation must be suspected if any of the following specific signs or symptoms are presented In the case of peripheral IV catheter - Possibly no initial symptoms of extravasation - Redness, pruritus, and edema around the injection site - Fluid injection rate slows down or stops - Blood backflow does not work well or there is leakage of medication around the needle - A complaint of discomfort or pain and occasional expression of searing pain or numbness - Initial physical symptoms usually appear immediately but also might appear several days or weeks later. In the case of central venous catheter - Often causes stinging pain 108 - Edema around the port insertion or in the chest, or medication leakage around the catheter insertion - Redness in the chest, collarbone, or neck where a central venous catheter is inserted - No blood backflow - Symptoms may appear early or late. Assessment Initial Acute assessment A site assessment should be conducted every hour when there are fluids or medications running through the line. If nothing is being infused, the site should be assessed before accessing the line and at least every eight hours. 109 Prevention of extravasion Vesicant agents should be admininsterd by qualified personal(Only staff who have completed appropriate training should administer chemotherapy unsupervised.) Cannulating over joints, the anticubital fossa or dorsum of the hand should be avoided when administering chemotherapy. Use a large vein in the forearm for peripheral vesicant administration. A new cannula ideally should be placed prior to the administration of chemotherapy. There is an increased risk of extravasation if a previously placed cannula is utilised. It is recommended that the smallest gauge cannula is placed in the biggest vein possible The vascular access device should be secured utilising a clear dressing that enables visibility whilst maintaining adequate fixation. Infusion lines must be secured effectively, however never cover the line with a bandage as the insertion point must be visible at all times. For infusion of vesicant drugs of longer duration (e.g. 12-24h) central venous access is highly recommended. Patients should be informed of the importance of reporting immediately any change in sensation, stinging or burning during the administration of chemotherapy Regularly check the extravasation kit and refill any used medications. Extravasation kit includes the following: 25G needle, 10-cc syringe, and 1-mL syringe; disinfection swabs, sterile gauze, and adhesive bandage; saline solution (1 ampule); sterile distilled water (1 ampule); dimethyl sulfoxide 99% solution; hyaluronidase 1,500 U/mL (refrigerated); hydrocortisone cream 1%; sodium thiosulfate 25% solution; and warm pack and an ice pack (frozen). 110 Note : Treatment of extravasation 111 At the first sign of extravasation, the following steps are recommended: (1) Stop administration of IV fluids immediately. (2) Disconnect the IV tube from the cannula. (3) Aspirate any residual drug from the cannula. (4) Administer a drug-specific antidote. (5) Notify the physician Elevation of the limb may aid in reabsorption of the infiltrate or extravasated vesicant by decreasing capillary hydrostatic pressure. Apply sterile dressing over the area of extravasation, regularly assess the extravasation site during every shift, and take medical photographs and consult the department of cosmetic surgery if necessary. Thermal application Local thermal treatments are used to decrease the site reaction and absorption of the infiltrate. Local cooling (ice packs) aids in vasoconstriction, theoretically limiting the drug dispersion. Cold application is recommended for extravasation of DNA-binding vesicants except for mechlorethamine (nitrogen mustard), contrast media, and hyperosmolar fluids. The use of local warming therapy (dry heat) is based on the theory that it enhances vasodilation, thus enhancing the dispersion of the vesicant agent and decreasing drug accumulation in the local tissue. The use of local warming is recommended for the extravasation of non– DNA-binding vesicants. Although clear benefit has not been demonstrated with thermal applications, it remains a standard supportive 112 care, and the recommended application schedule for both warm and cold applications is 15 to 20 minutes, every 4 hours, for 24 to 48 hours. Local cooling - It causes contraction of blood vessels, minimizing the spread of drugs to other tissues and reducing topical infections and pain. - Directions: apply cold fomentations for 15 to 20 minutes four to 6 times per day (for 1 day or more). Local warming - It dilates the blood vessels around the extravasation site, increases dispersion and absorption of the medicinal fluid by increasing the blood flow, and helps to quickly purge medicinal fluid that has leaked from the extravasation site. - Directions: apply hot fomentations for 20 to 30 minutes four to 6 times per day (for 1 day or more). Documentation: Because errors associated with IV administration can result in fatal or life-threatening outcomes, administration of IV fluids and medications can be a high-risk, with adverse outcomes potentially leading to malpractice claims. An incident of extravasation must be correctly documented and reported. Documentation procedure may differ between treatment centers (documentation form); however, certain items are mandatory for patient safety and legal purposes: (1) patient name and number, (2) date and time 113 of the extravasation, (3) name of the drug extravasated and the diluent used (if applicable), (4) signs and symptoms (also reported by the patient), (5) description of the IV access, (6) extravasation area (and the approximate amount of the drug extravasated), and (7) management steps with time and date. Photographic documentation can be helpful for follow-up procedures. 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