Pathophysiology Mechanisms poorly understood ↑ blood flow to the gum tissue ↑ tendency for gingival bleeding and ulceration Gingivitis ↑ neovascularizatio n lesions on skin Pyogenic granuloma of pregnancy (shiny red papule with a raspberry like surface) Pregnancy → hormonal and physical changes in the body ↑ human chorionic gonadotropin Mechanisms poorly understood Ptyalism (excessive salivation) Difficulty swallowing excess saliva ↑ estrogen ↓ mobilization of intracellular calcium within smooth muscle cells ↑ gallbladder stasis Liver displaced upwards Uterus rises into abdominal cavity Liver edge generally not palpable on exam ↑ blood pressure in veins within the abdomen Fluctuating hormone levels combined with pressure of growing fetus ↓ GI motility Delayed gastric and intestinal emptying Gastritis Dysgeusia Gallstones Cultural influences and psychological factors Change in diet and dietary cravings ↑ uterus size Smooth muscle relaxation in tissues such as the gallbladder & GI tract Biliary sludge given time to solidify within gallbladder Changes in taste prescription ↑ progesterone Vomiting, stomach pain, flatulence, & diarrhea Change in gut microbiome Stool builds up in colon, and hardens as water is absorbed Constipation ↑ intra-gastric pressure ↑ backup of stomach contents Nausea and vomiting In extreme case: Hyperemesis gravidarum Legend: PATHOPHYSIOLOGY SIGNS & SYMPTOMS COMPLICATIONS Veins around rectum and anus stretch under pressure Rectal bleeding & hemorrhoids