Dermatology Sun burn Exclusions: • Severe burns Appearance/Features: • Erythema 3-4 hours • Peak 12-24 hours Considerations: • Avoid topical anesthetics can sensitive to contact dermatitis Prevention: • Sunscreen the higher the SPF the better • Apply 15mins prior to sun exposure & every 2 hours or sooner during exposure Age: • Can happen at any age Complications: • Long term: Cancer and premature aging • Short term: Heat related illnesses such as dehydration • Short term: Exacerbate chronic illness such as SLE, Herpes, Eczema Pharm: • Analgesics for pain and inflammation o NSAIDS Non-Pharm: • Cool compress • Aloe to improve symptom intensity but doesn’t shorten duration Wounds Exclusions: • Full thickness • Burn > 2% BSA • Burn near eyes, ears, face, hands, feet, or perineum “Between genitals” • Chemical, electrical, or inhalation burns Appearance/Features: • N/A Considerations: • Risk factors for healing are: o Poor vascular blood flow Diabetes Hypotension Anemia o o o o Heart failure Bacterial infection Bad nutrition Older age Medications Corticosteroids Chemotherapy Immunosuppressants Goals: • Relieve symptoms • Promote healing • Minimize scarring Age: • N/A Complication: • N/A Pharm: • Skin protectants: o Examples: Allantoin Cocoa Butter Petrolatum Shark liver oil o Used to prevent friction and dryness o Apply as needed but if no results after 7 days seek medical attention • Topical Anesthetics: o Examples: Benzocaine Lidocaine Dibucaine Tetracaine Butamben Pramoxine o Block pain receptors for 15-45mins o Apply no more than 3-4 times per day o Do not use on more than 1-2% of BSA o Higher concentration may be used on intact skin • Topical Antiseptics: o Examples: Hydrogen peroxide Ethyl alcohol Isopropyl alcohol Iodine solution Povidone/Iodine o Limit risk of infection without causing tissue injury o Best for intact tissue o May dehydrate skin o Not for chronic use • Topical Antibiotics: o Examples: Polymyxin B sulfate Bacitracin zinc Neomycin o Prevent infections in burns and wounds o Can be applied 1-3 times per day o Not sufficient treatment for contaminated wounds o Seek medical attention after 7 days of no improvement o Not for prolonged use may cause bacterial resistance Non-Pharm: • Irrigation of wound • Cool compress burn • Non-Adherent hypoallergenic • Remove source of injury Dry Skin Considerations: • Usually, a symptom of a secondary issue such as hypothyroidism, asthma, and allergies • May be accompanied with Pruritis “itching” o Cool compress and use hydrocortisone for one week Prevention: • Short warm showers • Gentle soaps • Moisturize o Petroleum jelly, mineral oil, etc. • Wear cotton • Drink water • Use sunscreen and humidifier Atopic Dermatitis Eczema Exclusions: • Moderate to severe with intense pruritis • Large area of body involved • Less than a year old • Skin infection • Involvement in face or intertriginous areas • No improvement of rash with 3 days of self-care Appearance/Features: • Redness • Itching • Swelling • Skin lesion • Pattern: o Kids: Mostly on face, neck, and extensors o Adults: Current or previous flexural lesions, sparing of groin and axillary regions Considerations: • May use antibiotics for secondary infection • May use systemic corticosteroids for severe resistance disease o Short term only potential for rebound Prevention: • Maintain skin hydration • Limit exposure to triggers • Reduce pruritis • Prevent secondary infections Age: • Most common in kids but may outgrow it by adolescence Complication: Pharm: • First line: o Topical corticosteroids: Hydrocortisone 0.5-1% for ages 2 and above 1-2 times a day Continue to use 3 days after rash has cleared Max use 1 month for OTC ADR: • Local: skin thinning, atrophy, worsening acne, petechiae, and telangiectasia • Systemic: reduced linear growth in children and reduced bone density in adults o Drug selection based on age (lower potency) and location of lesion (lower potency near face, groin, axillae) • Second line: Prescription (Rx) o Topical Calcineurin inhibitors Pimecrolimus (Elidel) 1% or Tacrolimus (Protopic) 0.03-0.1% • Apply 2 times per day • Blocks T cell activation and Cytokine release Must be over 2 years old May cause malignancy Effectiveness similar to topical corticosteroids o Crisaborole (Eucrisa) PDE-4 inhibitor Mild-moderate above the age of 2 Apply two times a day ADR: local burning and stinging o Dupilumab (Dupixent) IL-4/IL-3 inhibitor Moderate-severe in adults only 600mg initial dose followed by 300mg every other week • Available in 300mg/2ml single use syringe Don’t use with live vaccines • Third line o May use UV phototherapy Non-Pharm: • Emollients o Apply 2 times per day after bathes • Bathing in warm water o Infants may bathe every 2-3 days • Cotton gloves and socks at bedtime Etiology: • Genetics • Environment • Impaired immune system Contact dermatitis Exclusions: • Difficulty breathing and fever • No improvement in rash after self-care • Rash increase in size • ADR from current treatment Appearance/Features: • Irritant: o Caused by direct injury to skin o Onset in minutes to hours o Resolution is fast upon removal of aggravating agent • Allergic: o Delayed hypersensitivity reaction o First exposure doesn’t provoke reaction, but re-exposure causes delayed response Hours to days o Caused by things like poison ivy, metals, smoke, local anesthetics, latex. Goals: • Relieve symptoms • Reduce secondary infections Pharm: • Astringents: o Examples: Calamine lotion, witch hazel, burrows solution o Topical vasoconstrictor o Decreases itching and oozing o ADR: Dry skin o Apply as a compress 15-30mins 2-4 times per day for a max of 7 days • Topical corticosteroids o Reduces inflammation pain and itching o Works in similar fashion as in atopic dermatitis o Apply 2-4 times daily for 7 days max • 1st generation antihistamines (systemic) o Examples: Diphenhydramine & Hydroxyzine o Decrease pruritis by blocking histamine reaction o ADR: Sedation and anticholinergic o For ages 2 and older o Topical antihistamines not as effective Non-Pharm: • Colloidal oatmeal bath • Cool soap less showers • Cool, moist compress for 30 minutes 3 times a day • Emollients after shower Diaper Dermatitis Exclusions: o Rash not responding to treatment o Rash extending beyond diaper area o Papules or ulceration formation o Oozing o Genital discharge o Fever o Bleeding Appearance/Features: • Pink is mild • Red is severe Considerations: • Form of irritant contact dermatitis Goals: • Prevent rash • Promote skin repair • Relieve discomfort • Prevent secondary infection Age: • Common in 3 months to 2 years old • Peak at 9-12 months • Can affect adults Pharm: • First line: o Protectants Example: • Zinc Oxide Form barrier between skin and diaper contents Mild-moderate use a cream or ointment Severe use a paste Apply with each diaper change o Topical corticosteroids Example: • Hydrocortisone cream 0.25-1% Limit use to low potency for no more than 2 weeks to avoid systemic absorption Not recommended for self-treatment o Topical antifungal Example: • Clotrimazole Diaper rash that lasts for longer than 48-72 hours increases risk of fungal infection Apply 2-4 times daily with diaper change Not recommended for self-treatment o Systemic antibacterial Most common bacteria are streptococci and staphylococcus Not recommended for self-treatment Non-Pharm: • Wash with warm water and mild soap • Keep diaper loose and ventilated • Avoid plastic pants • Allow naps in open diaper Prickly Heat AKA Miliaria Appearance/Features: o Miliaria Crystallina: Small thin-walled vesicles (Dew Drops) with no inflammation o Miliaria Rubia: Cluster of small papules with localized inflammation Etiology: o Excessive buildup of sweat below eccrine sweat ducts caused by keratin obstruction at the stratum corneum Considerations: o It is self-limiting once sweating is avoided Goals: o Alleviate symptoms o Promote healing of lesions o Prevent secondary infections Non-Pharm: o Cool environment o Light clothing o Cool bathes o Sodium bicarbonate 1 TSP- 1Cup topically o Avoid Talcum powder Seborrheic dermatitis and scalp disorders Exclusions: Appearance/Features: o Dandruff: Hyperproliferative, accelerated epidermal turnover, limited to crown of head, skin flaking and itching most common symptom o Seborrheic: Inflammation, epidermal cell turnover more rapid, extends beyond scalp, skin flaking and itching most common symptom o Oily o Relapsing o No oozing o Worse in dry conditions Considerations: o Associated with: o Hormone levels o Fungus o Nutritional defects o Neurogenic factors o HIV/AIDS Goals: o Reduce epidermal turnover o Minimize scaling, pruritus, and erythema o Can’t be cured just controlled Age: o Infants less than 3 months (cradle cap) o Adults 30-60 o More common in men Pharm: o Keratolytic agents (Scaling on scalp and no inflammation) o Examples: Pyrithione zinc may also be antifungal Coal tar Salicylic acid Sulfur o Use 2-3 times per week o Apply for at least 5 minutes prior to rinsing o Antifungal agents (SD of scalp and face) o Examples: Ketoconazole 1-2% (Nizoral) Selenium sulfide 1-2.5% (Selsun blue) Cicloprox 1-1.5% o Apply 2-3 times per week for scalp o Apply 2 times a day for non-scalp o Often used in combo with corticosteroids o Anti-inflammatory Agents o Corticosteroid Examples (SD of scalp and face): Fluocinolone 0.01% shampoo (Synalar) Twice a week Betamethasone valerate lotion (Beta-Val) Once or twice per week Desonide cream (Desowen) Once or twice daily o Calcineurin Inhibitor Examples (SD of face): Tacrolimus ointment (Protopic) Pimecrolimus cream (Elidel) One week for benefits to show Non-Pharm: o Tea tree oil shampoo (Melaleuca oil) o Available in 5% shampoo o Well tolerated and effective Alopecia Appearance/Feature: o Exogen phase > anagen phase o Hair enters telogen phase prematurely o Trauma to follicles Pharm: o Minoxidil (Rogaine) o For male and female o Prolongs anagen phase o Dosing: 1ml solution to scalp BID or ½ capful foam to scalp BID 2-5% for men 2% for women 5% foam for women once a day but solution not approved o Indefinite treatment o ADR: skin irritation, contact dermatitis, increased facial hair o Should use product for at least four months to see results and must be applied to APEX of scalp o Finasteride (Propecia) o Only for males o 5A reductase inhibitor Inhibits DHT formation o Dosing: 1mg tab PO daily o Indefinite treatment o ADR: Low libido, erectile dysfunction, gynecomastia, myopathy o Should use product for 3 months to see results, PSA levels low in elderly, prostate screenings still required o NON-FDA approved o Spironolactone For females with hyperandrogenic condition Dosing: 100-200mg PO daily Slows hair loss by blocking aldosterone receptors Insect bites Exclusions: Appearance/Feature: o Mosquito o Warm climates o Welt and itching o Injects anticoagulant o Can be vector for West Nile and Zika Virus o Fleas o Warm and humid climates o Redness and itching o Attracted to body heat o Clustered bites on legs and ankles o Can be vector for typhoid o Mite o Burrow under skin and lay eggs which causes scabies a contagious infection o Inflammation, intense itching, and immune response o Bites are between fingers, external male genitals, buttocks, and flexor of wrist o Bedbugs o Bite at night o Mild irritation to dermal hemorrhage o Can be vector for Hepatitis B o Ticks o Latch onto skin when biting and mouthparts remain on skin after removing o Intense itching and raised papules o Don’t apply petrolatum or oil to bite o Can be vector for: Rocky mountain fever: transmitted by wood or dog ticks Symptoms: Fever, rash, headache, and exhaustion o Appear 3-12 days after bite Lyme disease: transmitted by deer tick • Symptoms: inflammation of joints, heart, and nerves, bulls’ eye rash, flu and neurologic damage • Resolves in 3-4 weeks • RX: o Amoxicillin 500mg TID o Cefuroxime Axetil 500mg BID o Doxycycline 100mg BID o Initial treatment for 14 days • o Chiggers o Live in trees, shrubs, and grass o Red papule, intense itching, and hardening of skin o Attach to skin with bite and release digestive fluid o Spider o All are poisonous o Only black widow and brown recluse can break skin o BW: intense pain, stiffness of joints, fever, chills, dyspnea, abdominal pain o BR: all the above plus spreading ulcerated wound Consideration: o No OTC for scabies o RX: Permethrin 5% cream (Acticin) Lindane 1% lotion • 2nd line treatment Crotamiton 10% cream or lotion (EURAX) Antihistamines can be used as adjunct for itching o Ticks and spider bites must be seen by doctor o Must be confined to one area to self-treat Prevention: o Use covered clothes o Avoid swamps and standing water o Use insect repellent o DEET less than 30% in children o Citronella, lemon eucalyptus oil, lavender oil Goals: o Relieve symptoms o Prevent infection Age: o Must be over 2 years old Complications: o Risk of contact dermatitis with use of anesthetics and antihistamines o Need to limit systemic exposure by avoiding open wounds, occlusive Band-Aids, prolonged use, heated areas, and extensive application o Risk of atrophy, acne, and skin eruptions with topical corticosteroids o Be wary of systemic diseases such as Lyme and RMSF Pharm: o Local anesthetics o Examples: Benzocaine, Dibucaine, Pramoxine o Used for pain and itching o Use 3-4 times per day 7 days max o Dosage forms in cream, lotion, aerosol, and lotion o Topical antihistamines o Examples: Diphenhydramine 0.5-2% o Used for itching and pain o Use 3-4 times per day for 7 days max o Dosage forms in cream, gel, and spray o Topical hydrocortisone o Example: Hydrocortisone 1% o Used for itching, pain, and swelling o Use 3-4 times per day for 7 days max o Dosage form in creams and ointment o Not appropriate when infection present o Counterirritants o Example: Camphor 0.1-3% Menthol 0.1-1% o Used for itching and pain o Use 3-4 times per day for 7 days max o Dosage form in lotion and ointment o Skin protectants o Examples: Zinc oxide Calamine Titanium dioxide (Not FDA approved) o May reduce irritation and inflammation o Mild astringent, weak antiseptic, and absorb fluids from lesions Non-Pharm: o Ice pack o Trim nails to avoid itching Insect stings Exclusions: o Hives, weakness, vomiting o Allergic response o Previous sting by honeybee, wasp, or hornet o Less than 2 years old Appearance/Feature: o Honeybees o Have barbed stringers o Wasps, hornets, yellow jackets o No barb so multiple stings o Africanized killer bees o Very aggressive and swarming behavior o Multiple stings increase venom injection o Greater chance of severe allergic reaction o Fire ants o Bite and sting Bites inject venom o Symptoms: Intense itching, burning, tissue necrosis, and vesicle formation o Limited to no cross-sensitivity with flying insects Consideration: o Venomous stings contain an allergic protein Prevention: o Avoid perfumes and scents o Clean up picnics o Wear shoes o Destroy nests near home Goals: o Relieve pain and itching o Address allergic reactions o Hives/rashes o Burning sensation Pharm: o For stings: o Local anesthetic o Topical antihistamine o Counterirritants o Topical hydrocortisone o Skin protectants o Systemic antihistamines Not FDA approved o For allergic reaction: o Epinephrine Epi-pen • Not full treatment for allergic reaction Inject deep into muscle at 90 degree angle and hold for 5-10secs afterwards massage area Non-Pharm: o Ice pack for 10min intervals o Stinger removal o Scarping stinger away is the best way o Meat tenderizer o Ammonia and baking soda o Toothpaste o Papaya Urushiol induced dermatitis Exclusions: o Symptoms worsen o Rash is extensive o Face rash and swelling o Rash on genitals Appearance/Feature: o Poison ivy o Poison oak o Poison sumac o Most common form of allergic dermatitis o 1st exposure is sensitized o 2nd exposure is hypersensitivity Consideration: o Avoid antihistamines Prevention: o Get rid of plants near him Non-Pharm: o Wash exposed skin with soap o Cleanse exposed pets o Cool compress and showers Lice Exclusions: o Secondary infection o Lice in eyebrows or eyelids o Pregnancy or breastfeeding o Active tumors Appearance/Feature: o Head lice (Capitis) o Most common o Not a vector o No socioeconomic trend o Eggs NIT hatch to louse which must feed within 24hours o Louse bite and produce papule with redness and itching o NITs easier to spot than lice due to immobility o Lice die within 48 hours o Body lice (Corporis) o Lay eggs in clothes and folds of skin o Can be vector for Typhus o Common in people who don’t change or shower o Pubic lice (pubis) o Transmitted via clothing and sex Goals: o Kill lice o Remove eggs Age: o Older than 2 months Complications: o Avoid gasoline treatments Pharm: o Pyrethrins 0.33% o Examples: Rid shampoo Rid moose A-200 shampoo o Requires retreat 7-10 days o Ages 2 and older o Pyrethrins 1% o Examples: Nix cream o No retreatment required unless more lice found after 10days Residual effects for 10 days o Ages 2 months and older o Ivermectin 0.5% lotion o Example: Sklice o No retreatment o Ages 6 months and older o Abametpir 0.74% lotion o Example: Xeglyze o No retreatment required o Ages 6 months and older Non-Pharm: o NIT comb o Wash clothes in hot water o Vacuum o Body hygiene o Tea tree oil 10% with lavender oil 1% o Apply weekly for 3 weeks o Use with caution may cause liver damage and allergic reaction Fungal Skin Infection Exclusions: o Nails or scalp involved o Face, mucous membrane, or genitals involved o Diabetes, immune deficiency, or systemic infection o Bacterial infection o Exudation o Fever o Extensive inflammation Appearance/Feature: o Tinea pedis o Tinea unguium o In toenails and cannot be self-treated o Tinea corporis o Ring worm o Tinea cruris o Groin o Red is acute and hyperpigmented is chronic o More common in men o Tinea capitis o Skull o 4 subtypes: Non-inflammatory • Small papules surrounding hair shaft Inflammatory • Pain and pruritis Black Dot • Breaks off hair shaft at skin Favus • Patchy hair loss with yellow crust/scales o Pathogenic fungi: o Trichophyton o Microsporum o Epidermophyton Goals: o Symptomatic relief o Eradicate current infection o Prevent future infections Pharm: o Clotrimazole 1% (Lotrimin AF cream)/ Miconazole Nitrate 2% (Lotrimin AF powder spray) o Pedis: Apply twice a day for a month o Cruris: Apply twice a day for 2 weeks o Corporis: Apply twice a day for a month o Dosage forms: cream, spray liquid, spray powder o Terbinafine 1% (Lamisil) o Pedis: Apply twice a day for a week for interdigital and 2 times a week on soles and side o Cruris: Apply once daily for a week o Corporis: Apply once daily for a week o Dosage forms: Cream and Gel o Tolnaftate 1% (Tinactin) o Pedis: Apply twice a day for 2-4 weeks o Cruris: Apply twice a day for 2-4 weeks o Corporis: Apply twice a day for 2-4 weeks o Dosage forms: Powder, spray liquid, spray powder, cream, and solution o Butenafine 1% (Lotrimin Ultra) o Pedis: Apply twice a day for a week or daily for 4 weeks o Cruris: Apply once daily for two weeks o Corporis: Apply once daily for two weeks o Dosage form: cream o May take 4-6 weeks for results and may extend treatment o For sweating choose powder and for hard to reach choose spray Non-Pharm: o Limit spread o Clean skin o Keep skin dry o Bitter orange o Tea tree oil o Garlic Acne Exclusions: o Moderate to severe o Rosacea o Pregnant o Most OTC category C o No improvement with 6 weeks Appearance/Feature: o Black head: Open comedone o White head: Closed comedone Consideration: o Self-care for mild only o Refer if no improvement after 6 weeks Pharm: o Benzoyl peroxide 2.5-10% o Used in combination with other treatments o Example Proactive o May bleach clothes and hair o May cause photosensitivity o Improvement may take 4-6 weeks o Continue treatment after clearance to prevent new breakout o Start sparing at day 1-3 to assess sensitivity o May increase use to 2-3 times a day o Salicylic acid 0.5-2% o Not as effective as Benzoyl peroxide o Example OLAY o Causes photosensitivity o Improvement may take 4-6 weeks o Not for patients with poor circulation, diabetes, or salicylate toxicity o Avoid long term use o Start sparing at day 1-3 o Can increase to 2 times a day o Sulfur 3-10% & Resorcinol 2-8% o Not as effective as benzoyl o Example Stay clear o Use 1-3 times per day o May stain skin o Avoid sulfa allergic patients o Adapalene (Differin) Rx o Not as effective as Tazarotene o Causes photosensitivity o Use once a day at bedtime o Topical retinoids Rx o All dosed once daily at bedtime o More effective than OTC o Vitamin A analogs o Dapsone (Aczone) 5-7.5% gel Category C for pregnancy ADR: local irritation and peeling Oral linked to anemia Reassess after 12 weeks Use pea sized amount once daily for 7.5% and twice daily for 5% o Azelaic acid (Azelex) 20% cream Category B for pregnancy Use twice a day May lighten pigmentation of skin or cause irritation Mild photosensitivity Non-Pharm: o Wash with mild soap o Stay hydrated o Limit high glycemic foods WART Exclusions: Appearance/Feature: o An epidermal infection of HPV o Common: Viral induced and found on hands and feet o May be single or grouped papules o Cauliflower like appearance o HPV types 1,2,4,5,7,8,10 o Plantar: Viral induced found on sole of foot o Flat, circular, surrounded by thick skin o Thrombosed capillaries appear as dots beneath surface o May coalesce into mosaic warts o Flat o Mosaic o Myrmecia Consideration: o Spontaneous resolution within 2 years in 40% of patients o Most treatments 60-70% effective at 3 months none are 100% o Poor immune patients may never heal Prevention: o Wash hands after wart contact o Don’t walk barefoot o Don’t cut or probe wart o Don’t contaminate wart with clothing Goals: Age: Complications: Pharm: o Salicylic acid o Only approved OTC o First line for common, flat, and plantar o Plaster disk or pad 40% o Collodion 17% o Imiquimod (Aldara) Rx o Approved first line for flat o Expensive o 5% cream o Mixed results of efficiency o Bleomycin (Blenoxane) o 3rd line treatment for common and plantar o May cause pain, pigmentation changes, scarring, Raynauds phenomenon o Expensive and must be administered in doctor’s office o 15ml vial for injection reconstituted with 30ml of saline Non-Pharm: o Cryotherapy o Dye laser o Surgical o Oral/topical retinoids o Intralesional immunotherapy o Duct tape