ACTIVE LEARNING TEMPLATE
Medication
Michael Sanchez Bonilla
NAME______________________________________________________
CONTENT___________________________________________________ REVIEW MODULE CHAPTER________________
TOPIC DESCRIPTOR ____________________________________________________________________________________
Alteplase
MEDICATION___________________________________________________________________________________________
A recombinant DNA-derived form of human tissue type plasminogen activator that promotes
EXPECTED
PHARMACOLOGICAL thrombolysis by forming the active prteolytic enzyme, plasmin
ACTION:
Therapeutic Uses
Plasmin is capable of degrading fibrin, fribrinogen, and factors
V,VIII, and XII
Adverse Effects
Nursing Interventions
Internal and superficial bleeding stroke
Monitor for S&S of excessive
bleeding, neuro checks, no invasive
procedures, lab tests and frequent
vitals
Contraindications
Hypersensitivity to alteplase, active internal bleeding,
history of CVA, recent intracranial or interspinal surgery or
trauma. Severe liver or renal dysfunction
Client Education
Sudden headache, bloody or tarry
stool, any oozing or bleeding from
injection/insertion sites. Remain
quiet and on bedrest while receiving
this medication
Medication/Food Interactions
nausea and vomiting
Evaluation of Medication
Effectiveness
Medication Administration
Reconstitute the 50mg vial using a large bore needle (18
gauge), dilute contents with sterile water. Give 0.9% over
60 min with 10% of total dose as initial bolus over one
minute.
unwanted blood clots have
dissolved
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