CYSTIC FIBROSIS
Group 2
Apilan, Melfred
Clarin, Ricamae
Francisco, Ephesiany
Padilla, Lyza
Tantoy, Julie Mae
LEARNING OBJECTIVES
Discuss
the
pathophysiology of
the disease
Deliniate
the
laboratory finding’s of
the patient condition
Discuss and answer
the question given
CASE PROBLEM
A patient with known cystic fibrosis had 1 week cough and fever.
He was initially started with Amoxicillin+clavulanate, but it did not
resolve the condition. In the Emergency room, he had severe
dyspnea even with a rebreather mask at 10 liters per minute
oxygen supplement. The emergency room physician decided to
intubate the patient and suctioned a greenish thick and mucoid
tracheal aspirate which was collected for endotracheal aspirate
culture and sensitivity. There was a growth of non-fermenting
colonies on MacConkey agar. Smear showed non-spore forming
gram-negative bacilli which is sensitive to Chloramphenicol
antibiotic.
LABORATORY FINDINGS
MacConkey agar
Smear
Patient’s Results
greenish thick and
mucoid tracheal aspirate
growth of non-fermenting
colonies
non-spore forming gramnegative bacilli
sensitive to
Chloramphenicol
antibiotic
QUESTIONS AND ANSWERS
QUESTIONS:1. Which of the following is the causative organism?
a. Moraxella catarrhalis
b. Pseudomonas aeruginosa
c. Haemophilus influenzae
d. Burkholderia cepacia
The causative organism for cystic fibrosis is Burholderia cepacia.
2. What are the distinguishing characteristics of the causative agent?
The distinguishing characteristics of Burkholderia cepacia are
nonfermentive gram negative bacilli, non-spore forming, oxidase and
lactose positive and its colony morphology is colorless or yellow on
nutrient agar.
QUESTIONS AND ASNWERS
3. What other illnesses/diseases can be caused by this pathogen
and discuss each?(At least 3)
•Pneumonia- is an infection that inflames your lungs' air sacs
(alveoli). The air sacs may fill up with fluid or pus, causing symptoms
such as a cough, fever, chills and trouble breathing.
•Septicemia - is the clinical name for blood poisoning by bacteria. It
is the body's most extreme response to an infection.
•Chronic granulomatous - is an inherited disorder that occurs
when a type of white blood cell (phagocyte) that usually helps your
body fight infections doesn't work properly.
PATHOPHYSIOLOGY
Cystic fibrosis known by various other terms, such as
fibrocystic disease of the pancreas and mucoviscidosis. It
is an inherited autosomal recessive disorder,
characterized by dysfunction of mucuos and exocrine
glands throughout the body.
REFERENCES
Tille, P. M. (2014). Bailey & Scott's Diagnostic Microbiology. St. Louis,
Missouri:Elsevier
Bishop, M. L. (2020). Clinical Chemistry: Principles, Techniques, and
Correlations,
Enhanced Edition: Principles, Techniques, and
Correlations, Enhanced Edition (8th ed.). Jones & Bartlett
Learning.