EMILIO AGUINALDO COLLEGE
Gov. D. Mangubat St., Brgy. Burol Main, City of Dasmariñas, Cavite 4114, Philippines
Tel. Nos. (046) 416-4341-42www.eac.edu.ph
ISO 9001:2015 CERTIFIED
QUALITY MANAGEMENT SYSTEMS
SCHOOL OF NURSIN
NURSING
DRUG NAME
Hydroxyurea
Brand Name: Hydrea
Dosage: 15 mg/kg/day
Route: Oral
Frequency: Once daily
ACTION
INDICATION
CONTRAINDICATION
Hydroxyurea exerts 1. Treatment of sickle
cell anemia in adults
its
therapeutic
and children.
effects primarily by
increasing
the
production of fetal 2. Treatment of certain
types of cancer,
hemoglobin (HbF)
including
chronic
in red blood cells.
myelogenous
HbF interferes with
leukemia,
the polymerization
polycythemia vera,
of hemoglobin S
and
essential
(HbS), which is
thrombocythemia.
responsible for the
characteristic
sickling
of
red
blood cells in sickle
cell anemia. By
increasing
HbF
levels, hydroxyurea
helps to reduce the
frequency
and
severity of vasoocclusive
crises
and
other
complications
• VIRTUE
 Hypersensitivity
to
Hydroxyurea
(Some
individuals may be allergic or
hypersensitive
to
hydroxyurea or any of its
components)
 Severe Bone Marrow
Depression or Significant
Cytopenias (Hydroxyurea
can cause bone marrow
suppression, leading to a
decrease in the production
of blood cells due to another
medical
condition
or
previous treatment)
 Pregnancy (Hydroxyurea
has been associated with
an increased risk of birth
defects when used during
pregnancy)
• EXCELLENCE
G
ADVERSE REACTION
NURSING RESPONSIBILITIES
 Bone Marrow Suppression
(Anemia,
Leukopenia,
Thrombocytopenia)– a decrease
in blood cell counts can occur,
which may lead to anemia,
increased
susceptibility
to
infections and an increased risk of
bleeding

Conduct a thorough
patient
assessment,
including medical history,
current medications, and
any known allergies, to
ensure that hydroxyurea
is appropriate for the
patient

Nausea and Vomiting– due
to the irritation of the
gastrointestinal mucosa

Monitor vital signs,
including blood pressure,
pulse, respiratory rate,
and temperature, before
and after administering
hydroxyurea
 Diarrhea– It may result from
changes in the gastrointestinal
tract's normal functioning
 Rash- The development of a
rash may be a sign of an allergic
reaction or intolerance to the
medication

Headache, Fever, and
Fatigue- These symptoms are
considered non-specific side
• SERVICE

Emphasize
the
importance of adherence
to the prescribed dosage
and schedule and the
need for regular follow-up
appointments and blood
tests.
EMILIO AGUINALDO COLLEGE
Gov. D. Mangubat St., Brgy. Burol Main, City of Dasmariñas, Cavite 4114, Philippines
Tel. Nos. (046) 416-4341-42www.eac.edu.ph
ISO 9001:2015 CERTIFIED
QUALITY MANAGEMENT SYSTEMS
SCHOOL OF NURSIN
NURSING
effects and may be associated
with various underlying
mechanisms, including the
potential effects of hydroxyurea on
the central nervous system
associated
with
sickle cell disease.
Classification:
Antineoplastic
agent, Antisickling
agent
• VIRTUE
G

Hair Loss- typically occurs
due to the impact of the
medication on rapidly dividing
cells, such as hair follicle cells
• EXCELLENCE
• SERVICE

Administer
the
medication with a full
glass of water and at the
same time each day, as
prescribed

Monitor and manage
common side effects,
such as nausea, vomiting,
diarrhea, and headache.
Administer anti-nausea
medications
as
prescribed.