EMILIO AGUINALDO COLLEGE Gov. D. Mangubat St., Brgy. Burol Main, City of Dasmariñas, Cavite 4114, Philippines Tel. Nos. (046) 416-4341-42www.eac.edu.ph ISO 9001:2015 CERTIFIED QUALITY MANAGEMENT SYSTEMS SCHOOL OF NURSIN NURSING NAME: Crizelle Andrea A. Dungca DRUG NAME Hydroxyurea Brand Name: Hydrea Dosage: 15 mg/kg/day Route: Oral Frequency: Once daily ACTION G COURSE TITLE: MS1 RLE INDICATION CONTRAINDICATION Hydroxyurea exerts 1. Treatment of sickle cell anemia in adults its therapeutic and children. effects primarily by increasing the production of fetal 2. Treatment of certain types of cancer, hemoglobin (HbF) including chronic in red blood cells. myelogenous HbF interferes with leukemia, the polymerization polycythemia vera, of hemoglobin S and essential (HbS), which is thrombocythemia. responsible for the characteristic sickling of red blood cells in sickle cell anemia. By increasing HbF levels, hydroxyurea helps to reduce the frequency and severity of vasoocclusive crises and other complications • VIRTUE Hypersensitivity to Hydroxyurea (Some individuals may be allergic or hypersensitive to hydroxyurea or any of its components) Severe Bone Marrow Depression or Significant Cytopenias (Hydroxyurea can cause bone marrow suppression, leading to a decrease in the production of blood cells due to another medical condition or previous treatment) Pregnancy (Hydroxyurea has been associated with an increased risk of birth defects when used during pregnancy) • EXCELLENCE ADVERSE REACTION NURSING RESPONSIBILITIES Bone Marrow Suppression (Anemia, Leukopenia, Thrombocytopenia)– a decrease in blood cell counts can occur, which may lead to anemia, increased susceptibility to infections and an increased risk of bleeding Conduct a thorough patient assessment, including medical history, current medications, and any known allergies, to ensure that hydroxyurea is appropriate for the patient Nausea and Vomiting– due to the irritation of the gastrointestinal mucosa Monitor vital signs, including blood pressure, pulse, respiratory rate, and temperature, before and after administering hydroxyurea Diarrhea– It may result from changes in the gastrointestinal tract's normal functioning Rash- The development of a rash may be a sign of an allergic reaction or intolerance to the medication Headache, Fever, and Fatigue- These symptoms are considered non-specific side • SERVICE Emphasize the importance of adherence to the prescribed dosage and schedule and the need for regular follow-up appointments and blood tests. EMILIO AGUINALDO COLLEGE Gov. D. Mangubat St., Brgy. Burol Main, City of Dasmariñas, Cavite 4114, Philippines Tel. Nos. (046) 416-4341-42www.eac.edu.ph ISO 9001:2015 CERTIFIED QUALITY MANAGEMENT SYSTEMS SCHOOL OF NURSIN NURSING effects and may be associated with various underlying mechanisms, including the potential effects of hydroxyurea on the central nervous system associated with sickle cell disease. Classification: Antineoplastic agent, Antisickling agent • VIRTUE G Hair Loss- typically occurs due to the impact of the medication on rapidly dividing cells, such as hair follicle cells • EXCELLENCE • SERVICE Administer the medication with a full glass of water and at the same time each day, as prescribed Monitor and manage common side effects, such as nausea, vomiting, diarrhea, and headache. Administer anti-nausea medications as prescribed.