Pharmaceutical Excipient Our Team Name: Md Fayshal Talukdar Name: Ashique Ahmed Name: Elias Hossain Shanto Name: Mohammad Rakibul Islam ID: 211-29-1755 ID: 211-29-1754 ID: 211-29-434 ID: 211-29-430 Department Of Pharmacy Department Of Pharmacy Department Of Pharmacy Department Of Pharmacy 01 Key points 02 03 04 Introduction Types of Excipient Roles & Effects Conclusion What Is Pharmaceutical Excipient ? Pharmaceutical excipients are substances added to drug formulations to improve their performance and ensure drug delivery. These excipients are selected based on their compatibility with biopharmaceutical principles, which focus on how drugs are absorbed, distributed, metabolized, and eliminated in the body. Types Of Pharmaceutical Excipients • • • • • • • • • • Surfactant Emulsifiers Binders Co solvents Fillers Disintegrates Lubricants suspending agents Antimicrobials preservatives Surfactant: • Surfactant play a crucial role in pharmaceutical formulations, particularly when dealing with poorly water-soluble drugs. They are chosen based on biopharmaceutics parameters to enhance the solubility and bioavailability of these drugs. Role Of Surfactant : • Surfactant are excipients that improve the solubility of hydrophobic or lipophilic drugs in aqueous media, such as the gastrointestinal fluids. • They help convert poorly soluble drugs into a more soluble form, increasing the concentration of the drug in solution, which is crucial for absorption in the body. Selection Criteria: When selecting Surfactant, pharmaceutical scientists consider various biopharmaceutics parameters: Log P (Partition Coefficient) pKa (Acid Dissociation Constant Absorption Site Emulsifiers : Emulsifiers are pharmaceutical excipients that play a vital role in drug formulations, especially when dealing with lipid-based drug delivery systems. Role Of Emulsifiers : • emulsifiers are used to solubilize lipophilic drugs in an aqueous environment, improving their bioavailability. • They also aid in the dispersion and uniform distribution of drug particles in the emulsion, ensuring consistent dosing. Binder: • Binders are substances added to tablets and other solid dosage forms to improve their mechanical strength and cohesiveness. In biopharmaceutics binders can have several effects. Effect of Binder: • Binders in pharmaceutical formulations can have effects on the ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs.They are: Absorption • Rate of Absorption • Gastrointestinal Transit Distribution • Drug-Excipient Interactions Metabolism • Drug Stability Elimination • Renal Excretion Lubricant: • Lubricants in pharmaceutical formulations play a crucial role in tablet and capsule manufacturing, primarily by reducing friction between particles and equipment during the compression process.While lubricants are not typically considered a direct factor in biopharmaceutics they can indirectly impact certain aspects of drug Effects of lubricants on biopharmaceutics: • Uniformity and Consistency • Tablet Disintegration • Manufacturing Efficiency Adverse Effects of lubricant : • some cases, lubricants might cause adverse effects, especially if patients are sensitive or allergic to specific lubricant ingredients. Although this is relatively rare, it underscores the importance of selecting appropriate lubricants and ensuring they are well-tolerated by the patient population Antimicrobial agent • The use of antimicrobial agents, such as antibiotics, antifungals, and antivirals, can significantly impact bio pharmaceutics—the study of how drugs are released, absorbed, distributed, metabolized, and excreted in the body. 01 Key points of Infection Control 02 Drug-Pathogen Interactions 03 Drug Absorption 04 Drug Interactions antimicrobial agents on bio pharmaceutics 05 Tissue Penetration Adverse Effects of antimicrobial agent • Antimicrobial agents can have side effects or adverse reactions, and these should be monitored as part of biopharmaceutical considerations. Managing adverse effects may require dosage adjustments or discontinuation of treatment. Fillers • Fillers, also known as diluents or bulking agents, are excipients used in pharmaceutical formulations to increase the bulk or volume of a tablet or capsule. they can have several effects on biopharmaceutics. Several Effects of 01 Dosage Uniformity 02 Tablet Disintegration 03 Drug Dissolution 04 Drug Absorption Fillers Conclusion excipients are integral to the successful development and performance of biopharmaceutical products. Their role in enhancing bioavailability, formulation stability, drug delivery, and immunogenicity mitigation is pivotal in ensuring the safety and efficacy of these advanced therapies. Moreover, the close attention paid to regulatory considerations and the customization of excipients for biopharmaceuticals are key factors in their continued advancement in the field of medicine.
