"The Clever Machine" provides a comprehensive introduction to Artificial Neural Networks (ANNs) and their applications. The article begins by acknowledging the existence of both linear and nonlinear phenomena in the world and the need for diverse models to address them. It introduces parametric models, which fine-tune parametric functions to fit data, and kernel-based methods that transform data into abstract spaces for predictions. However, it is ANNs that take center stage in the article. ANNs, inspired by the structure of the nervous system, are explained as systems of simple, nonlinear computations that can collectively represent complex nonlinear functions. Their remarkable flexibility is highlighted: ANNs can approximate virtually any nonlinear function, making them a potent tool. The article explores single-layer neural networks, elucidating their role in linear regression and binary classification, along with the significance of different activation functions. It then delves into multi-layer neural networks, emphasizing their capability to model intricate nonlinear relationships through hidden layers. The training process of ANNs is introduced, emphasizing error minimization through gradient descent and the crucial role of the backpropagation algorithm in efficiently computing gradients for parameter updates. Overall, the article offers a holistic view of ANNs, balancing mathematical insights with practical implementations, and exemplifying their strengths and weaknesses through toy examples. It underscores ANNs' computational power and their intriguing intersection with computational neuroscience, providing readers with a solid foundation for understanding and utilizing these versatile models.