Gluten is a protein that consists of glutenin and gliadin. The latter is what makes up most
of the body’s reaction to gluten and is “responsible for most of the adverse health effects”
(medicalnewstoday.com). This includes gluten allergies, intolerance, and celiac disease. Celiac
disease, also known as gluten-sensitive enteropathy, is a genetically susceptible disease. Now the
human leukocyte antigen (HLA) is a complex of proteins that orchestrate and regulate the
immune system. Our body is made to recognize these antigens as normal and positive to the
body. However, celiac is considered to be an autoimmune disorder. Disorders are defined as
“irregularity, disturbance, or interruption of normal functions” (webstersdictionary). This means
that a disorder can be regulated and return to normal functions if put under certain stresses and
actions are taken. According to Trowsdale J., “extreme polymorphism and possible mutations in
the MHC [HLA] increases the chance of autoimmune diseases”. There is a test to find the
relative risk for celiac called HLA typing. HLA sensitisation can occur through pro inflammatory
events.