Chief complaint Mr S a 46 years old Malay gentleman presented to the emergency department with chief complaints of abdominal pain for 2 days. History of presenting illness He experienced the epigastric pain while about to sleep at night. It was dull aching pain radiating to the right iliac fossa and persistent with severity of 5 out of 10 for pain scale. There is no aggravating and relieving factor. He tried to tolerate the pain until the next morning, he vomited. It was fluid content, non bilious and no blood. He was brought up to the emergency department by his wife. In the Emergency department he had one episode of loose stool. Otherwise, no history of eating outside food and contact illness. There is no fever, no left lower quadrant pain, irregular bowel habits and per rectal bleeding. No intermittent loin to groin pain and hematuria. He normally passess motion once daily and has normal urinary habits. No loss of weight and appetite. He denies any chest pain, shortness of breath, cough and trauma. Past medical and surgical history There is no recent admission to hospital and no past surgical history Drug history He was not on any medication. No over the counter medication or traditional medicine. Family history Patient has three siblings and he is the third. His older brother and sister are well. Both of his parents are healthy. No family history of peptic ulcer disease and malignancy. Social history He is a chronic smoker who smokes 1 pack per day for the past 20 years. He did not consume alcoholic drinks. His diet consists of nasi lemak with tea for breakfast, mixed rice for lunch and dinner. He mentioned that he loves to eat spicy food. He currently lives in Mengkibol with his wife who is a housewife and is blessed with one child. He works as an automotive service technician. No recent history of traveling. Vital sign: Heart rate: 84 beats per minute Respiratory rate: 18 breaths per minute Temperature: 37.2°C Blood pressure: 118/76mmHg (78) SpO2 99% under room air Pain Score: 3/10 Anthropometry: Weight 52kg Height 1.7m Body Mass Index (BMI) 18.3kg/m2 All vital signs were normal. He is underweight, stable and afebrile. Examination in Emergency department The abdomen was flat and normal. No past surgical scar and masses noted. There was mild tenderness at the epigastric region and noted rebound tenderness at the right iliac fossa and Mc Burney’s point. General examination in ward Patient is thin built, well hydrated and cooperative. He was lying supine on bed and not in respiratory distress and obvious pain. Patient is well, no pallor, jaundice, and pedal edema noted. Abdominal examination The patient was lying supine with leg extended. The abdomen was flat and normal in shape. The umbilicus was centrally located and flat. The abdomen moves with respiration. There were no peristaltic movements, pulsating swelling and obvious masses observed. The skin was normal and hernial orifices were intact. Abdomen was soft and tenderness was present at the McBurney’s point upon deep palpation. Rebound tenderness was present and Rovsing signs were positives. No hepatosplenomegaly. No ascites were noted. Bowel sounds were present. The rectal examination was normal. The external genitalia and scrotum were normal. Cardiorespiratory examination: There is no chest deformity and the apex beat located at the 5th left intercostal along the midclavicular line. There was no thrill or parasternal heave. The first and second heart sounds were appreciated and no additional heart sound or murmur. No pedal oedema. Respiratory examination: The trachea was central. The chest rises equally with breathing. Air entry was equal bilaterally and vesicular breath sounds were heard upon auscultation of the lung. No crepitations were heard on the base of the lungs. Musculoskeletal and nervous systems: Grossly normal. 1. Full blood count Justification: To rule out anemia, look for leukocytosis and thrombocytosis as a sign of acute infection Parameters Value (29/7/2023) Unit Normal range White blood cell 16.62 10 /L 5 – 15.5 Red blood cell 4.94 10 /L 3.8 – 5.8 Haemoglobin (Hb) 13.5 g/dL 11.5 – 15.5 Haematocrit 39.9 % 35 – 45 9 12 MCV MCH MCHC Platelet RDW - CV Neutrophil Lymphocyte 80.8 27.3 33.8 287 14.0 78.6 11.2 fL pg g/dL 10 /L % % % 9 80.6 – 95 27 – 32 31 – 37 150 – 400 12 – 14.8 40 – 80 10 - 50 Interpretation: There is leukocytosis with neutrophils predominantly. Otherwise other blood parameters were normal. 2. Renal profile Justification: To rule out possible renal impairments, dehydration and electrolyte imbalance. (29/7/2023) Unit Normal Range Urea 3.4 mmol/L 3.0 – 9.2 Sodium 141 mmol/L 136 – 145 Potassium 4.1 mmol/L 3.5 – 5.1 Chloride 109 mmol/L 98 – 107 Creatinine 91.0 μmol/l 63.6-110 Interpretation: There was normal kidney function and no electrolyte imbalance. 3. Urine full examination microscopic examination: Justification: To rule out urinary tract infection and dehydration Value Glucose negative Protein negative Blood Trace Leucocytes negative Nitrites negative Ketone ++ Normal Interpretation: Ketone is 2+ meaning blood ketone concentration was 1.6 to 3.0 mmol/L. Patient is dehydrated. 4. Liver function test Justification: No justification Parameters 29/7/2023 Unit Normal Range Total Bilirubin 10.8 μmol/L 3.4 – 20.5 ALP 58 u/L 40 - 150 Total Protein 71 g/L 64 - 83 Albumin 42 g/L 34 - 48 AST 16 u/L 3 - 34 ALT 19 u/L 0 - 55 Interpretation: The liver function tests were normal . There is no clinical significance in evaluating acute appendicitis. 5. Abdominal x-ray Justification: To look for air fluid levels and dilated bowel due to obstruction. Interpretation: Normal abdominal radiograph 6. Erect Chest x-ray Justification:t To look for air under the diaphragm as sign of viscus perforation Interpretation: Normal chest radiograph 7. Random blood glucose Justification: To rule out diabetes mellitus, stress condition can cause hyperglycemia Interpretation: Blood glucose was 6.9mmol/L, normal. 8. ECG Justification: To rule out inferior myocardial infarction Interpretation: Sinus rhythm with no ST changes. Working diagnosis Acute appendicitis Plan of management on admission Management in Emergency Department 1. He was given Magnesium Trisilicate 15 ml 2. For his pain relief, IV Tramadol 50 mg TDS, IV Maxolon 10 mg and IV Pantoprazole 40 mg was given 3. Blood was taken for FBC, RP, LFT and Urine full examination microscopic examination 4. Chest and abdominal radiograph was requested 5. Start IV normal saline was given for 1 hour 6. Referral to surgical department was made Mr S was admitted to ward 8B for further history and management of acute appendicitis. In the ward, he was lying supine, alert and saturating under room air with stable vital signs. The in ward management plan is: 1. Nil by mouth at 2 am, allow orally first 2. IVD 4 pints normal saline for 24 hours once patient nil by mouth (2NS, 2DS). 3. For IV Augmentin 1.2g STAT and TDS 4. For Tab Paracetamol 1g QID STAT 5. Continue IV Tramadol 50 mg TDS and IV Pantoprazole 40 mg OD 6. Watchout hypertensive tachycardia 7. Reassess abdomen the next morning 8. KIV for laparoscopic appendectomy if worsening 9. For OGDS later The staff nurse noted that his blood pressure was 87/56 mmHg and clinically, the patient had right iliac fossa pain with a pain score of 2/10. Physical examination noted that upon deep palpation there is tenderness at the right iliac fossa. He was given 1 pint of Gelafusin bolus and to keep Mean Arterial Pressure above 70 mmHg. Then, another branula was inserted and strict input output charting was done. His antibiotics were changed to Tazocin 4.5g QID and IVI Noradrenaline 0.2mcg/kg/min was given. He was stabilised after that with blood pressure of 126/65 mmHg prior to his operation. Operation: Lower midline laparotomy and appendectomy and abdominal washing Pre and postoperative diagnosis: Perforated appendicitis Intraoperative findings: Pus 3 cc at the right iliac fossa Appendix at pelvic position Perforated tip, edematous appendix Base healthy Small bowel no meckels Terminal ileum mild distended Drain inserted at pelvis Estimated blood loss is minimal Postoperative plan: 1. FBC, RP, ABG in ward 2. Wound inspection day 3(2/8/23) 3. Suture to open day 14 (13/8/23) 4. Drain charting 5. Keep MAP ≥ 75mmHg. Keep IVI Norad 6. Input output charting 7. Nil by mouth with IVD 4 pints normal saline dextrose for 24 hours 8. Keep Ryles tube free flow 9. Continue to IV Tazocin 4.5g QID 10. Continue PCA morphine and Tab Paracetamol 1g QID then oralise to C. Tramadol 50 mg TDS 11. TED stocking and ripple mattress 12. Start subcutaneous Clexane 40 mg OD He is conscious with vital signs of 97/64mmHg (MAP 70 mmHg) and heart rate 61 beats per minute, afebrile and saturating under room air. He was on Ryles tube free flow and he can tolerate pain over the operation site. He was on PCA morphine and IVI Noradrenaline 0.05mcg/kg/min in view of low blood pressure.