Far Eastern University – Nicanor Reyes Medical Foundation GROSS RADIO – B: INTRODUCTION-DIAGNOSTIC IMAGING AUGUST 2020 Dr. Chito • • • • - FILM RADIOGRAPHY Utilizes a screen-film system within a film cassette (x-ray detector) OVERVIEW Diagnostic Imaging Methods Naming Radiographic Views Basic Radiography Densities Cross-sectional Imaging DIAGNOSTIC IMAGING METHODS CONVENTIONAL RADIOLOGY HISTORY 1895 – Wilhelm Conrad Roentgen produced the 1st x-ray image PROCEDURE (1) Patient is positioned (4) X-RAY film is read thru a negatoscope - (2) X-RAY is taken (3) Film cassette is taken to the dark room for developing X-RAY Form of radiant energy similar to visible light Has very short wavelength Penetrates many substances that are opaque to light Produced by bombarding a tungsten target with an electron beam within an x-ray tube - COMPUTED RADIOGRAPHY (CR) Filmless system No processing Produces digital radiographic images Substitutes a phosphor imaging plate for the film screen cassette How is an x-ray film produced in conventional radiography? X-rays pass through the body (a) à x-rays are attenuated by interaction with body tissue (a) à transmitted x-rays through the patient bombard a fluorescent particle-coated screen (b) in the film cassette à produces photochemical interaction à light rays are emitted, which exposes the film (c) in the cassette à film is developed How is an x-ray film produced in computed radiography? X-rays pass through the body à phosphor-coated imaging plate interacts with x-rays transmitted through the patient à phosphor plate is placed within a reading device à data is captured and processed into a digital image 1 PROCEDURE (1) Patient is positioned (2) X-RAY is taken (4) Digital image developed is read thru a monitor (3) Film cassette is placed in a computed radiography processing machine - NAMING RADIOGRAPHIC VIEWS Most x-ray views are named on the basis of the way that an x-ray beam passes through the patient Views are also named by the position of the patient Naming on the basis of the way that an x-ray beam passes through the patient: - - DIGITAL RADIOGRAPHY (DR) Also a filmless system Substitutes a fixed electronic detector on charge-coupled device for the film screen cassette or phosphor imaging plate à NO CASSETTE NEEDED Immediate images are produced through direct readout PROCEDURE (1) Patient is positioned (2) X-RAY is taken Chest posteroanterior (PA) Chest anteroposterior (AP) Naming on the basis of the position of the patient: (3) Digital image is read thru a monitor Abdomen left lateral decubitus Abdomen upright 5 BASIC RADIOGRAPHY DENSITIES - - FLUOROSCOPY Real time radiographic visualization of moving anatomic structures Continuous x-ray beam passes through the patient and falls on a fluorescing screen à produces a light pattern which is amplified electronically à amplified real time images are displayed on a monitor Useful in evaluating motion such as gastrointestinal peristalsis, movement of diaphragm during respiration, and cardiac action. Also used to monitor continuously radiographic procedures such as Barium studies and catheter placements Air density - Lungs Fat density - Subcutaneous tissue Soft tissue density - Heart Bone density - Ribs Metal/contrast density - Pacemaker 2 Air density - Bowel gas - Fat density - Flank stripe - Soft tissue density - Liver - Bone density - Pelvis MAMMOGRAPHY Makes use of low-energy x-rays (30 kVp) to examine the human breast Indication: o Screening o Diagnostic Two views: o Craniocaudal view o Mediolateral view Metal/contrast density - Barium What is attenuation? • • • • Process by which a beam of radiation is reduced in intensity when passing through material If a tissue has low attenuation it would suggest that it is relatively transparent and appears dark (Example: air/gas) High attenuation is a denser material and (bone) objects appear brighter In general, the denser the material, the better its ability to attenuate x-ray beam, the brighter/whiter it would appear on x-ray images AIR DENSITY Air attenuates very little of the xray beam – most are transmitted à black on radiograph - - BONE AND METAL DENSITY Bone, metal and contrast agents attenuate a large proportion of xray beam à white on radiograph FAT AND SOFT TISSUE DENSITY Fat and soft tissue attenuate intermediate amounts of x-ray beam à shades of gray on radiograph CROSS-SECTIONAL IMAGING TECHNIQUES CT, MR, and Ultrasound – techniques that produce cross-sectional images of the body Produces slices of patient tissue to produce a two-dimensional image To analyze optimally all of the anatomic information of any particular slice, the image is viewed at different window-width and windowlevel settings, which are optimized for bone, air-filled lung, soft tissue, etc. COMPUTED TOMOGRAPHY (CT) Uses a computer to mathematically reconstruct a cross-sectional image of the body from measurements of x-ray transmission through thin slices of patient tissue Displays each imaged slice separately No superimposed blurred structures seen in conventional tomography The patient is placed on an examination. An x-ray tube rotates 360° around the patient, producing pulses of radiation that pass through the patient. Transmitted x-rays are detected by a circumferential bank of radiation detectors. Types of CT scan: • Conventional CT (nonhelical) Obtains image data one slice at a time – one slice per breath hold Requires at least two to three times the total scanning time of helical CT • Helical CT (spiral CT) Performed by moving the patient table through the gantry while scanning continuously with an x-ray tube rotating around the patient Continuous volume of image data is acquired during a single breath-hold Improved speed of image acquisition Improved visualization of small lesions 3 • Multidetector helical CT (MDCT) Latest technical advance in CT imaging Like helical scanner but with multiple rows of detector rings Obtains multiple slices per tube rotation à increases the area of the patient that can be covered in a given time 5-8 times faster than single-slice helical CT Allows for high-detail CT angiography and virtual CT colonoscopy and bronchoscopy Disadvantage: radiation dose, 3-5 times higher than with single-slice CT Advantages of CT compared with MR: Rapid scan acquisition Superior bone detail, and demonstration of calcifications PRINCIPLES OF INTERPRETATION • • Like radiography, images are dependent on the degree of attenuation by different materials Hounsfield Units (HU) – Units of x-ray attenuation used in CT scanning the brighter the tissue, the higher the HU • • HOUNSFIELD UNIT (HU) SCALE • • • • • • Air: -1,000 H Lung tissue: -400 to -600 H Fat: -60 to -100 H Water: value of 0 H Soft tissue: +40 to +80 H Bone: +400 to +1,000 H • • • Gray scale: in the left edge Centimeter scale: along the right side of the image R: patient's right side L: patient's left side Cross-sectional images in the transverse plane are routinely viewed from “below,” as if standing at the patient's feet Optimal bone detail is viewed at bone windows Window width of 2,000 H, window level of 400 to 600 H Lungs are viewed at lung windows Window width of 1,000 to 2,000H, window levels of about 500 to 600H Soft tissues Window width of 400 to 500 H, window level 20 to 40H LUNG WINDOW PLANES a to c: AXIAL/ TRANSVERSE d: CORONAL e: SAGGITAL SOFT TISSUE WINDOW 4 • • CONTRAST ADMINISTRATION IN CT Intravenous iodine-based contrast agents are administered in CT to: Enhance density differences between lesions and surrounding parenchyma To demonstrate vascular anatomy and vessel patency To characterize lesions by their patterns of contrast enhancement Oral or rectal contrast is generally required to opacify the bowel for CT scans of the abdomen and pelvis. Bowel without intraluminal contrast may be difficult to differentiate from tumors, lymph nodes, and hematomas. CONTRAST ADMINISTRATION IN MR: Gadolinium chelates Given to: Identify regions of disruption of the blood-brain barrier Enhance organs to accentuate pathology Document patterns of lesion enhancement • • SAFETY CONSIDERATIONS IN MRI Contraindicated in patients who have electrically, magnetically, or mechanically activated implants Cardiac pacemakers, insulin pumps, cochlear implants, neurostimulators, bone-growth stimulators, and implantable drug infusion pumps Intracardiac pacing wires or Swan-Ganz catheters Ferromagnetic implants, such as cerebral aneurysm clips, vascular clips, and skin staples Bullets, shrapnel, and metallic fragments Safe for MR Nonferromagnetic vascular clips and staples and orthopaedic devices Prosthetic heart valves with metal components Pregnant patients can be scanned, provided the study is medically indicated • • • A – PLAIN B – WITH CONTRAST PRINCIPLES OF INTERPRETATION • MAGNETIC RESONANCE IMAGING (MRI) Produces tomographic images by means of magnetic fields and radio waves Based on the ability of a small number of protons within the body to absorb and emit radio wave energy when the body is placed within a strong magnetic field - • • Soft tissue contrast is obtained through imaging sequences that accentuate differences in T1 and T2 tissue relaxation times Water is the major source of the MR signal in tissues other than fat Mineral-rich structures, such as bone and calculi, and collagenous tissues, such as ligaments, tendons, fibrocartilage, and tissue fibrosis, are low in water content and lack mobile protons to produce an MR signal low in signal intensity on all MR sequence FREE WATER in MRI - - • Most tissues can be differentiated by differences in their T1 and T2 relaxation times T1 is a measure of a proton's ability to exchange energy with its surrounding chemical matrix o It is a measure of how quickly a tissue can become magnetized T2 conveys how quickly a given tissue loses its magnetization ADVANTAGES OF MR: • Outstanding soft tissue contrast resolution • Provides images in any anatomic plane • Absence of ionizing radiation DISADVANTAGES OF MR: • Limited in its ability to demonstrate dense bone detail or calcifications • Involves long imaging times for many pulse sequences • Possesses limited spatial resolution compared with CT • Limited availability in some geographic areas • Expensive Found mainly as extracellular fluid, also as intracellular free water Organs with abundant extracellular fluid: o Kidneys (urine) o Ovaries and thyroid (fluid-filled follicles) o Spleen and penis (stagnant blood) o Prostate, testes, and seminal vesicles (fluid in tubules) Edema (increase in extracellular fluid) Most neoplastic tissues have increase in extracellular fluid as well as an increase in the proportion of intracellular free water à bright signal intensity on T2WIs Ventricles and sulci contain CSF à black on T1 , white on T2 PROTEINACEOUS FLUIDS IN MRI - Addition of protein to free water shortens T1 relaxation time – bright T2 relaxation is also shortened, but the T1 shortening effect is dominant even on T2WIs -- remain bright on T2Wis Synovial fluid, complicated cysts, abscesses, many pathologic fluid collections, and necrotic areas within tumors 5 ULTRASONOGRAPHY - T1W T2W A complicated rectal cyst showing hyperintensity on both T1 and T2 images - SOFT TISSUES ON MRI - - Soft tissues that have a predominance of intracellular bound water have shorter T1 and T2 times than do tissues with large amounts of extracellular water Liver, pancreas, adrenal glands, and muscle -- intermediate signal intensities on both T1WIs and T2WIs - ULTRASOUND Utilizes pulse-echo technique Transducer converts electrical energy to a brief pulse of highfrequency sound energy transmitted into patient à transducer becomes a receiver, detecting echoes of sound energy reflected from tissue à composite image is produced Produces nearly real-time images of moving patient tissue o Enables assessment of respiratory and cardiac movement, vascular pulsations, peristalsis, and moving fetus Images may be produced in any anatomic plane by adjusting the orientation and angulation of the transducer and the position of the patient. o Standard orthogonal planes: axial, sagittal, and coronal Visualization of structures by US is limited by bone and gascontaining structures (e.g. bowel and lung) ULTRASOUND PROBE – transducer and a receiver. T1W T2W FAT ON MRI - T1 relaxation time is short = bright signal T2 of fat is shorter than T2 of water = lower signal intensity for fat, relative to water On images with lesser degrees of T2 weighting, T1 effect predominates and fat appears isointense or slightly hyperintense compared with water. STIR sequences suppress signals from all tissues with short T1 times, including fat Subcutaneous fats are bright on both T1 and T2 PLANES • • • Sagittal/longitudinal Transverse/axial Coronal AXIAL/TRANSVERSE FLOWING BLOOD ON MRI - Higher-velocity blood flow alters the MR signal in complex ways, depending on multiple factors. o High-velocity signal loss predominates in spin-echo imaging, resulting in signal void “black blood” in areas of flowing blood. SAGGITAL/LONGITUDINAL Patent Blood Vessels 6 LIMITATION OF ULTRASOUND • • - Bone: Sound energy is nearly completely absorbed at interfaces between soft tissue and bone (rib, R), causing an acoustic shadow limiting visualization of structures deep to the bone surface ULTRASOUND ARTIFACTS ACOUSTIC SHADOWING Gallbladder stone Bone (rib) ACOUSTIC ENHANCEMENT Cyst Gallbladder COMET-TAIL ARTIFACT Arises from normal pleura (*) reflecting sound waves Adenomyomatitis on th bladder Air: Soft tissue-gas interfaces (bowel loop) cause nearly complete reflection of the sound beam, preventing visualization of deeper structures Bowel wall DOPPLER ULTRASOUND Adjunct to real-time gray-scale imaging Detects reflection of the sound wave from a moving object – RBC in flowing blood Can detect presence of blood flow and its direction and velocity DOPPLER ULTRASOUND OF THE CAROTID ARTERY PRINCIPLES OF ULTRASOUND INTERPRETATION 7 FLUID-CONTAINING STRUCTURES HYPERECHOIC Dilated renal calyces & pelvis ANECHOIC SOLID TISSUE (FATTY TISSUE) Fatty liver Lipoma SOLID ORGANS (P) Pancreas Kidney HYPOECHOIC Liver Focal nodular hyperplasia 8 Terminology RADIOGRAPH ULTRASOUND CT SCAN Density • Radiolucent: black • Radiopaque /Radiodense: white Echogenicity • Anechoic: black • Hypoechoic: darker than parenchyma • Hyperechoic: whiter than parenchyma • Isoechoic: same as parenchyma Density • Hypodense: darker • Hyperdense: whiter than parenchyma • Isodense: same as parenchyma MRI Echogenicity • Hypointense: darker than parenchyma • Hyperintense: whiter than parenchyma • Isointense: same as parenchyma T1 T2 how quickly a tissue can become magnetized how quickly a given tissue loses its magnetization Hyperintense Lower intensity than water Hyperintense Intermediate intensity Air Fat Radiolucent Moderately radiolucent Not visualized Hyperechoic Black Hypodense Hypointense Hypointense Water/Fluids Soft Tissue Moderately radiopaque Moderately radiopaque Anechoic Varying echogenicity Hyperdense Varying hyperdensity Bone/Metal Very radiopaque Not visualized Very hyperdense Hypointense Intermediate intensity Hypointense Hypointense SOURCES: 1. PPT 2020 9