Please cite this article as: Ali, Amira Mohammed; Ahmed, Anwar; Sharaf, Amira; Kawakami, Norito; Abdeldayem, Samia M.; Green, Joseph. Analysis of the Arabic version of The Depression Anxiety Stress Scale-21: cumulative scaling and discriminant validity testing. Asian Journal of Psychiatry https://doi.org/10.1016/j.ajp.2017.07.018 The Arabic Version of The Depression Anxiety Stress Scale-21: cumulative scaling and discriminant-validation testing Abstract Objective: This study aimed to examine the validity of the Arabic version of the Depression Anxiety Stress Scale-21 (DASS-21) in 149 illicit drug users. Methods: We calculated α coefficient, inter-tem and item-total correlations, coefficients of reproducibility and scalability (CR and CS), item difficulty and discrimination indices. Results: The DASS-21 had an acceptable reliability; but values of the CR and the CS were less than acceptable. Items varied in difficulty and discrimination; some items are candidates for elimination. Conclusion: The DASS-21 is a probabilistic and not a deterministic measure of distress; it has problematic items and needs further investigations. Keywords: DASS-21; discriminant validity, drug users; Guttman scalogram.